CN100998776B - Traditional Chinese medicine effervescent tablets for inducing sweat, cleaning damp and harmonizing middle-jiao, and its preparing method - Google Patents

Traditional Chinese medicine effervescent tablets for inducing sweat, cleaning damp and harmonizing middle-jiao, and its preparing method Download PDF

Info

Publication number
CN100998776B
CN100998776B CN200610011171XA CN200610011171A CN100998776B CN 100998776 B CN100998776 B CN 100998776B CN 200610011171X A CN200610011171X A CN 200610011171XA CN 200610011171 A CN200610011171 A CN 200610011171A CN 100998776 B CN100998776 B CN 100998776B
Authority
CN
China
Prior art keywords
parts
radix
adjuvant
effervescent
fructus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200610011171XA
Other languages
Chinese (zh)
Other versions
CN100998776A (en
Inventor
李祖泽
施少斌
郑荣波
沈军
黄晓丹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Original Assignee
WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY filed Critical WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Priority to CN200610011171XA priority Critical patent/CN100998776B/en
Publication of CN100998776A publication Critical patent/CN100998776A/en
Application granted granted Critical
Publication of CN100998776B publication Critical patent/CN100998776B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

A Chinese medicine in the form of effervescent tablet for relieving exterior syndrome, dispelling dampness and regulating stomach is prepared from 16 Chinese-medicinal materials including uncaria stem with hooks, magnolia bark, trichosanthes root, tuckahoe, etc. Its preparing process is also disclosed.

Description

A kind of induce sweat, dry and in Chinese medicine effervescent tablet and preparation method thereof
Technical field
The present invention relates to field of medicaments, particularly, relate to Chinese medicine be a kind of that raw material is made induce sweat, dry and in Chinese medicine effervescent tablet and preparation method thereof.
Background technology
Stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset, dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache are clinical common symptoms, these symptoms can be caused by multiple reason.In Song dynasty " formulary of peaceful benevolent dispensary " these symptoms are put down in writing to some extent, and the prescription of ageratum side as treatment is provided.Ageratum side is described as " heat-damp in summer panacea " by ancient Chinese medicine doctor.This side have induce sweat, damp eliminating and in effect, be usually used in treating the treatment of affection of exogenous wind-cold, internal injury humidity hysteresis, stomachache vomiting and diarrhoea clinically, mainly be with stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache etc. are clinical manifestation, also are widely used at present the treatments such as common cold of gastrointestinal type, acute chronic enteritis of modern medicine.Health pill is a kind of traditional Chinese medicine, is the novel formulation that develops on the basis of the former technology of the positive invigorating oral liquid of traditional Radix agastaches, and China's " pharmacopeia " includes it wherein already.Health pill have induce sweat, damp eliminating and in function; Be mainly used in stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, the treatment of fever and headache.The Health pill of putting down in writing in the pharmacopeia adopts the method for making of " each pulverizing medicinal materials; general ball; coating ", its productive labor intensity is big, with low content of technology, prescription Chinese medicine effective ingredient is not extracted, thereby cause Health pill to exist the medicine active ingredient in gastrointestinal dissolution rate and absorbance reduction, soak time prolongs, and onset is slow, and because Health pill bad smell when taking can make the patient produce resentment.
Chinese invention patent number 200410027334.4 titles are made and are protected the Ji sheet, decoct with water owing to Ramulus Uncariae Cum Uncis in its technology that adopts, be not easy to extract fat-soluble effective ingredient in the Ramulus Uncariae Cum Uncis, and multiple medical material as: Six-element medicines such as the Radix Aucklandiae, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Pogostemonis adopt CO respectively 2The process more complicated of extraction, the cycle of finishing production is long, and cost is higher.
Effervescent tablet begins to be used for oral drug preparation in recent years.Because the effervescent effect of effervescent can be accelerated dispersion and the dissolution velocity of medicine in water, and have easy to carry, steady quality, bioavailability height, the fast characteristics of drug effect.
Summary of the invention
The purpose of this invention is to provide a kind of have induce sweat, dry and in the Chinese medicine effervescent.
Another object of the present invention provide a kind of have induce sweat, dry and in active constituents of medicine.
Another object of the present invention provide a kind of have induce sweat, dry and in the preparation method of Chinese medicine effervescent.
Medicine of the present invention is to be made by Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis.By test, a kind of effervescent tablet for the treatment of headache of in many adjuvants, selecting definite effervescent adjuvant to make.It is little, soluble in water that the selected effervescent adjuvant of the present invention has a molecular weight, and disintegration rate is fast, pure natural degree height, toxic and side effects is lower, owing to itself promptly be the food correctives, so can reduce the medicine irritation abnormal smells from the patient, take that mouthfeel is good, the acceptant characteristics of patient.
The selection of the consumption of drug component of the present invention and disintegrating agent adjuvant thereof also gropes to sum up to draw through the inventor in a large number, this medicine is formed and is comprised following raw materials in weight portion: 15.50～55.80 parts of Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss, 105～12000 parts of effervescent adjuvants, wherein the effervescent adjuvant comprises carbon dioxide source, acid source, disintegrating agent and filler:
Acid source wherein is selected from following one or more adjuvant: citric acid, tartaric acid, fumaric acid, adipic acid, malic acid, water-soluble amino acid, boric acid, citric acid;
Carbon dioxide source is selected from following one or more adjuvant: calcium bicarbonate, sodium carbonate, sodium bicarbonate, sodium bitartrate, potassium carbonate, potassium bicarbonate;
The fillibility adjuvant is selected from following one or more adjuvant: Polyethylene Glycol, erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, isomalt, lactose, maltose and they contain the water of crystallization chemical compound;
Disintegrating agent is selected from following one or more adjuvant: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
The amounts of components and the effervescent adjuvant of preferred medicine of the present invention comprise following materials of weight proportions medicine: 27.17～41.20 parts of Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss, 105～6700 parts of effervescent adjuvants, wherein the effervescent adjuvant comprises carbon dioxide source, acid source, disintegrating agent and filler:
Acid source wherein is selected from following one or more adjuvant: citric acid, fumaric acid, malic acid, boric acid, citric acid;
Carbon dioxide source is selected from following one or more adjuvant: calcium bicarbonate, sodium carbonate, sodium bicarbonate, sodium bitartrate;
The fillibility adjuvant is selected from following one or more adjuvant: Polyethylene Glycol, xylitol, lactose and they contain the water of crystallization chemical compound;
Disintegrating agent is selected from following one or more adjuvant: pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, cyclodextrin, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
The amounts of components and the effervescent adjuvant of further preferred medicine of the present invention comprise following materials of weight proportions medicine: 34.10 parts of Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss, 380～4560 parts of effervescent adjuvants; Wherein the effervescent adjuvant comprises carbon dioxide source, acid source, disintegrating agent and filler:
Acid source wherein is selected from following one or more adjuvant: citric acid, boric acid, citric acid; Carbon dioxide source is selected from following one or more adjuvant: sodium carbonate, sodium bicarbonate; The fillibility adjuvant is selected from following one or more adjuvant: Polyethylene Glycol, xylitol, lactose; Disintegrating agent is selected from following one or more adjuvant: pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, cyclodextrin, methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
Preferred medicine effervescent adjuvant of the present invention, wherein, acid source is selected from following one or more adjuvant: citric acid, citric acid; Carbon dioxide source is selected from following one or more adjuvant: sodium carbonate, sodium bicarbonate; The fillibility adjuvant is selected from following one or more adjuvant: xylitol, lactose; Disintegrating agent is selected from following one or more adjuvant: pregelatinized Starch, modified starch, microcrystalline Cellulose, hydroxypropyl emthylcellulose, hydroxyethylmethyl-cellulose, cyclodextrin, hydroxyethyl-cellulose, hydroxypropyl cellulose.
Best medicine effervescent adjuvant of the present invention, wherein, acid source is: citric acid; Carbon dioxide source is: sodium bicarbonate; The fillibility adjuvant is selected from following one or more adjuvant: xylitol, lactose; Disintegrating agent is selected from following one or more adjuvant: pregelatinized Starch, cyclodextrin.
The effervescent adjuvant is 1: 0.1～1 with the ratio of the gross weight of Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis extract among the present invention.
Preferred effervescent adjuvant of the present invention is 1: 0.1～1: 0.6 with the ratio of the gross weight of Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis extract.
Best effervescent adjuvant of the present invention is 1: 0.2～1: 0.4 with the ratio of Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis extract gross weight.
Disintegrating agent in the effervescent adjuvant among the present invention: acid source: the ratio of the weight of carbon dioxide source is 0.1～1.5: 0.1～1: 0.1～1: 0.1～1.
Disintegrating agent in the effervescent adjuvant among preferred the present invention: acid source: the ratio of the weight of carbon dioxide source is 0.3～1: 0.3～0.8: 0.25～0.7: 0.3～0.7.
Disintegrating agent in the effervescent adjuvant among best the present invention: acid source: the ratio of the weight of carbon dioxide source is 0.5～0.8: 0.4～0.6: 0.3～0.6: 0.4～0.6.
Among the present invention, disintegrating agent in the effervescent adjuvant: acid source: the ratio of the weight of carbon dioxide source is 0.1～1.5: 0.1～1: 0.1～1: 0.1～1.
Among preferred the present invention, disintegrating agent in the effervescent adjuvant: acid source: the ratio of the weight of carbon dioxide source is 0.3～1: 0.3～0.8: 0.25～0.7: 0.3～0.7.
Among best the present invention, disintegrating agent in the effervescent adjuvant: acid source: the ratio of the weight of carbon dioxide source is 0.5～0.8: 0.4～0.6: 0.3～0.6: 0.4～0.6.
The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.Medicine of the present invention can adopt the conventional preparation method preparation of at present common effervescent.The present invention can adopt wet granulation: acid and/or alkali are granulated respectively, mix before tabletting, tabletting is made effervescent tablet; The present invention can adopt non-water to granulate: the extract dry ingredient is granulated with on-aqueous liquid (as ethanol) in will writing out a prescription, and tabletting is made effervescent tablet; The present invention can adopt direct compression process: with suitable component mix homogeneously, direct compression is made effervescent tablet; The present invention can adopt the dry granulation method: with component with hydraulic pressure or double compression corning.
The present invention adopts following technology to extract, and employing is prepared as follows method and prepares effervescent tablet, is intended to further specify the present invention, but the present invention is not construed as limiting.
Process for preparing medicine of the present invention comprises the steps:
A. get 15.50～55.80 parts of crude drug Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 1～10 times of amount; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 1～4 time of 2～10 times of amounts, and each 0.5～5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 2～10 times of amounts, 30～99% ethanol extractions 1～4 time, and each 0.5～4 hour, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder, dextrin embedding thing and effervescent adjuvant mixing granulation, tabletting.
Preferred process for preparing medicine of the present invention comprises the steps:
A. get 27.17～41.20 parts of crude drug Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3～8 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 1～3 time of 3～8 times of amounts, and each 0.5～3 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 3～8 times of amounts, 50～95% ethanol extractions 1～3 time, and each 0.5～3 hour, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder, dextrin embedding thing and effervescent adjuvant mixing granulation, tabletting.
The preparation method of further preferred medicine of the present invention comprises the steps:
A. it is standby to get 34.10 parts of crude drug Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3.5～6 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3.5～6 times of amounts, and each 1～2 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 3.5～6 times of amounts, 55～90% ethanol extractions 2 times, and each 1～3 hour, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder, dextrin embedding thing and effervescent adjuvant mixing granulation, tabletting.
The preparation method of best medicine of the present invention comprises the steps:
A. it is standby to get 34.10 parts of crude drug Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 4.5 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 4 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 70% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder, dextrin embedding thing and effervescent adjuvant mixing granulation, tabletting.
In the above process for preparing medicine, acid source, carbon dioxide source can wrap up with Polyethylene Glycol separately, or with other adjuvants parcels, react in governance process to reduce.
Can add an amount of correctives such as Oleum menthae, menthol, artificial Rhizoma et radix valerianae, Cortex Cinnamomi and other fruity etc. in the medicine of the present invention.
Can add an amount of sweeting agent in the medicine of the present invention as sugar, saccharin sodium, Calcium o-benzolsulfimide, cyclohexane sulfamic acid (sodium), glycyrrhizin, alcohol sugar, radix asparagi sweet extract etc.
Can also add moderate lubrication agent such as Stepanol MG, Polyethylene Glycol, magnesium stearate (calcium), hydrogenated vegetable wet goods in the medicine of the present invention.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
To those skilled in the art, technology contents disclosed according to the present invention, those skilled in the art will very clear other embodiment of the present invention, and the embodiment of the invention is only as example.Under the situation of not violating purport of the present invention and scope, can carry out various changes and improvements to the present invention.For example; use different effective ingredients or active constituents of medicine and effervescent adjuvant provided by the invention to adopt identical or obstructed preparation method to make effervescent; but as long as use effervescent adjuvant of the present invention, all within protection domain of the present invention.
The specific embodiment
In order to understand the present invention better, logical below test example is further set forth the beneficial effect of medicine of the present invention.These test examples comprise the pharmacodynamics test of medicine of the present invention.Below used medicine prepares according to embodiment 15 methods in the test.
One, medicine of the present invention is to the mice gastric emptying, the influence of intestinal propulsion
Medicine of the present invention according to the preparation of embodiment 15 methods, grinds, and adds water and becomes pasty state.
Control drug: Health pill, commercially available, adopt identical pastel.
1. adopt the semi-solid gastric emptying experimental technique of mice, observe medicine of the present invention normal mouse and dopamine hydrochloride are caused the influence of mice delayed gastric emptying, the result shows: (1) medicine of the present invention, Health pill are not obvious to the normal mouse gastric emptying.(2) the simple dopamine hydrochloride group of nutrition paste residual quantity significantly reduces (P＜0.01 or P＜0.05) in two dosage of medicine of the present invention (1.85g/kg, 3.70g/kg), Health pill (1.85g/kg), fourth woods (5mg/kg) stomach, and medicine of the present invention, the Health pill of prompting doses all have antagonism to the mice delayed gastric emptying that dopamine hydrochloride causes.
2. adopt mouse small intestine charcoal end propulsion trial, observe medicine of the present invention and contrast medicine Health pill, and at neostigmine, epinephrine, atropine cause that mouse small intestine advances antagonism hyperfunction or that suppress the propulsive influence of small intestine movement of mice.The result shows that (1) medicine low dose of the present invention has the propulsive effect of the small intestine movement of mice of quickening, and two dosage effects of middle and high dosage and Health pill are not obvious.(2) small intestinal that causes at neostigmine of two dosage of middle and high dosage of medicine of the present invention and Health pill is hyperfunction an inhibitory action.(3) medicine high dose of the present invention causes that to atropine intestinal propulsion suppresses antagonism is arranged, and two dosage effects of little, middle dosage and Health pill are not obvious.(4) three dosage of medicine of the present invention cause that at epinephrine intestinal propulsion suppresses antagonism is arranged, and the Health pill effect is not obvious.
Above result shows, medicine doses of the present invention causes that at neostigmine mouse small intestine advances the hyperfunction inhibitory action that has, and the mouse small intestine that epinephrine or atropine are caused advances and suppresses also to have certain antagonism.Results suggest, medicine of the present invention has regulating action to mice gastric emptying, intestinal motility disorder.One of symptom that medicine of the present invention cures mainly is a gastrointestinal upset, dyspepsia, and both all can show the gastrointestinal motility dysfunction, this effect should be that its treatment gastrointestinal is not transported, one of dyspeptic pharmacological action.
The result shows, drug effect of the present invention and Health pill effect acquaintance, and medicine of the present invention also causes that to epinephrine intestinal propulsion suppresses antagonism is arranged, and Health pill except that epinephrine is caused mouse small intestine advance the effect that suppresses not obvious.
Two, medicine antidiarrheal of the present invention, analgesia and spasmolysis test.
1. the test of mouse anti diarrhoea shows: three dosage of medicine of the present invention and two dosage of Health pill cause the diarrhea of mouse model with Folium Sennae obvious diarrhea effect.Show as 6 hours accumulative total of administration group and rush down following just number of times than the obvious minimizing of matched group (P＜0.05 or P＜0.01), in the medicine wherein of the present invention, low dose of (3.70g/kg, 1.85g/kg), and Health pill low dose (1.85g/kg) after giving the agent of Folium Sennae diarrhea inducing second 2 hours and the 3rd were rushed down down just in 2 hours, and number of times also obviously reduces (P＜0.05 or P＜0.01) than matched group.
2. (1) hot-plate analgesic test shows: after medicine low dose of the present invention (1.85g/kg) administration 120 minutes, 90 minutes, 120 minutes pain thresholds were than the obvious rising of matched group (P＜0.05 or P＜0.01) after middle high dose (3.70g/kg, the 5.55g/) administration; Dosage in the Health pill (3.70g/kg), high dose administration 60 minutes, pain threshold was than the obvious rising of matched group (P＜0.05 or P＜0.01) in 90 minutes.
(2) test of acetic acid twisting method shows, each dosage group of medicine of the present invention and Health pill and matched group are relatively, the equal no significant difference incubation period of writhing response (P＞0.05), medicine high dose group of the present invention (5.55g/kg) is turned round the body number of times and is obviously reduced (P＜0.05) than matched group, two dosage groups of Health pill also have certain minimizing, but difference not significantly (P＞0.05).
The result shows that medicine of the present invention and Health pill have certain analgesic activity, but onset is slow and effect a little less than.
3. the test of isolated rabbit small intestinal and stripped small intestine of guinea pig spasmolysis shows that medicine doses of the present invention causes that to acecoline the spastic contraction of isolated rabbit ileum has certain antagonism.The spastic contraction of guinea pig ileum that histamine phosphate is caused has tangible antagonism, and the tonicity of dosing metagaster obviously descends.
Results suggest, medicine of the present invention has certain spasmolysis, and the Health pill spasmolysis of same dose is not obvious.
Three, medicine Chinese People's Anti-Japanese Military and Political College's Mus acute gastric mucosal lesion of the present invention and to the influence of rat tolerance secretion
1. adopt the sticking damage model of touching of acidic alcohol rat acute stomach; observe the sticking effect of touching damage of anti-acute stomach of medicine of the present invention and Health pill; the result shows that three dosage of medicine of the present invention (0.925g/kg, 1.85g/kg, 33.70) and Health pill (1.85g/kg) can reduce obviously that the stomach of rat model is sticking touches damage index, and the stomach of point out two kinds of preparations that some foreign substance is caused glues to be touched acute injury protective effect is arranged.
2. adopt rat pylorus ligature law stomachial secretion test to show, in the medicine of the present invention in, low dosage (1.85,0.925g/kg) do not have tangible influence to the pylorus ligation rat tolerance secretion; High dose (3.70g/kg) shows as gastric secretion, total acid output obviously reduces than matched group, points out this dosage that gastric acid secretion is had inhibitory action.Health pill (1.85g/kg) does not have tangible influence to stomachial secretion.
In order to understand the present invention better, below with medicine test disintegration explanation of the present invention advantage of the present invention.
Test example 1: effervescent tablet of the present invention experiment disintegration
In vitro tests
By measuring medicine of the present invention disintegration, whether ripe, whether be fit to suitability for industrialized production if investigating its releasing effect and preparation technology thereof.
1. test medication: medicine effervescent tablet of the present invention (according to the preparation of embodiment 15 methods).
2. method and result:
Disintegration: according to nineteen ninety-five the version official method detect disintegration.
Get 1 of effervescent tablet and put in the 250ml beaker that fills 200ml water, water temperature 15-25 ℃, see that bubble emits.When gas stopped to overflow, tablet was answered disintegrate and dissolving, no aggregated particle residue.The record disintegration time.Repeat to survey 6, must exceed equal disintegration of value.
Result of the test sees Table one.
6 batches in table one medicine effervescent tablet of the present invention disintegration
Figure G2006111171X20060116D000091
Insoluble matter has (+) not have (-)
By table one as seen, medicine dissolution of the present invention and disintegration are more satisfactory, and all disintegrates within 5min disintegration of 6 batches the medicine effervescent tablet of the present invention of getting meet the requirement of Chinese Pharmacopoeia nineteen ninety-five version.
Test example 2: medicine effervescent tablet reserved sample observing of the present invention relatively
1. test medication: medicine effervescent tablet of the present invention (according to the preparation of embodiment 15 methods).
2. method and result: three batches of the things of getting it filled are loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed the effervescent tablet surface condition, the results are shown in Table two.
6 batches of medicine effervescent tablet reserved sample observings of the present invention of table two
Figure G2006111171X20060116D000101
Result of the test shows that it is little that each batch of medicine effervescent tablet of the present invention sees that adhesion phenomenon changes, but the effervescent tablet suitability for industrialized production that adopts this prescription and effervescent adjuvant to make is described.
Further set forth the preparation method of medicine of the present invention by the following examples.
Embodiment 1:
A. get prescription one: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 80.40g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 80.40g, Guangdong Massa Medicata Fermentata 80.40g, Fructus Tribuli 15.50g, Rhizoma Atractylodis 80.40g, Radix Puerariae 80.40g, Exocarpium Citri Grandis 36.70g, Fructus Oryzae Germinatus 55.50g, Flos Chrysanthemi 36.70g, Radix Aucklandiae 80.40g, Herba Pogostemonis 80.40g, Herba Menthae 36.70g, Semen Coicis 95.20g are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil dextrin embedding gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 10g, cyclodextrin inclusion compound 1g, it is standby to add xylitol 12g, xanthan gum 3g, sodium bicarbonate 30g, starch 10g, citric acid 20g; With the above-mentioned raw materials mix homogeneously, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 2:
A. get prescription two: Ramulus Uncariae Cum Uncis 55.80g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 205.80g, Poria 423.20g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 324.80g are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil dextrin embedding gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated into an amount of drying, pulverizes, and gets the dry extract fine powder;
C. get above-mentioned dry extract 9g, cyclodextrin inclusion compound 1g, xylitol 12g, xanthan gum 3g, sodium bicarbonate 30g, starch 10g, citric acid 20g are standby, with dry extract, cyclodextrin inclusion compound, xylitol, xanthan gum, sodium bicarbonate, starch, fully mix, dry, sieve, granulate, obtain spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 3:
A. get prescription three: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 95.20g are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil betacyclodextrin embedding gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder 3g and dextrin embedding thing 1g mix homogeneously, add xylitol 20g, pregelatinized Starch 5g, sodium bicarbonate 25g, starch 9g, citric acid 30g, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 4:
A. get prescription four: Ramulus Uncariae Cum Uncis 41.20g, Cortex Magnoliae Officinalis 163.68g, Radix Trichosanthis 123.17g, Poria 327.85g, Radix Angelicae Dahuricae 165.56g, Guangdong Massa Medicata Fermentata 165.56g, Fructus Tribuli 41.20g, Rhizoma Atractylodis 163.68g, Radix Puerariae 163.68g, Exocarpium Citri Grandis 81.73g, Fructus Oryzae Germinatus 123.17g, Flos Chrysanthemi 81.73g, Radix Aucklandiae 163.68g, Herba Pogostemonis 163.6g, Herba Menthae 81.73g, Semen Coicis 206.10g are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and the embedding of volatile oil dextrin gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 4 times, each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 4 times, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated into an amount of drying, pulverizes, and gets the dry extract fine powder;
C. get above-mentioned dry extract 15g, cyclodextrin inclusion compound 0.5g, xylitol 8g, arabic gum 5g, microcrystalline Cellulose 10g, citric acid 12g, sodium carbonate 14g fully mix above-mentioned raw materials, and drying is sieved, and granulate, and obtain spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 5:
A. get prescription five: Ramulus Uncariae Cum Uncis 27.17g, Cortex Magnoliae Officinalis 109.12g, Radix Trichosanthis 81.80g, Poria 217.94g, Radix Angelicae Dahuricae 109.12g, Guangdong Massa Medicata Fermentata 109.12g, Fructus Tribuli 27.17g, Rhizoma Atractylodis 109.12g, Radix Puerariae 109.12g, change Fructus Citri tangerinae 54.48g, Fructus Oryzae Germinatus 81.80g, Flos Chrysanthemi 54.48, Radix Aucklandiae 109.12g, Herba Pogostemonis 109.12g, Herba Menthae 54.48g, Semen Coicis 136.77g are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and the embedding of volatile oil dextrin gets dextrin embedding thing, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1 time extracted 4 hours, and the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 2 times, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 6g, cyclodextrin inclusion compound 1g, add lactose 15g, Lac 10g, hydroxyethyl-cellulose 20g, pregelatinized Starch 10g, calcium bicarbonate 30g, tartaric acid 26g, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 6
A. get prescription six: Ramulus Uncariae Cum Uncis 34.10g, Cortex Magnoliae Officinalis 136.40g, Radix Trichosanthis 102.30g, Poria 272.80g, Radix Angelicae Dahuricae 136.40g, Guangdong Massa Medicata Fermentata 136.40g, Fructus Tribuli 34.10g, Rhizoma Atractylodis 136.40g, Radix Puerariae 136.40g, Exocarpium Citri Grandis 68.20g, Fructus Oryzae Germinatus 102.30g, Flos Chrysanthemi 68.20g, Radix Aucklandiae 136.40g, Herba Pogostemonis 136.40g, Herba Menthae 68.20g, Semen Coicis 170.50g are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 3 times, each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 3 times, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, must be in the extractum fine powder;
C. get above-mentioned dry extract 9g, cyclodextrin inclusion compound 1g, Polyethylene Glycol 8g, hydroxypropyl emthylcellulose 5g, gelatin 4g, sodium bicarbonate 8g, fumaric acid 6g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 7:
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 2 times, each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 2 times, merge extractive liquid,, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 5g, cyclodextrin inclusion compound 5g, crospolyvinylpyrrolidone 10g, hydroxypropyl emthylcellulose 5g, lactose 4g, sodium bitartrate 6g, tartaric acid 5g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 8:
A. get prescription, it is standby with embodiment 2 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with a certain amount of dextrin embedding, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 2 times, each hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, Radix Angelicae Dahuricae ethanol extraction 1 time, merge extractive liquid, reclaims ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 22g, cyclodextrin inclusion compound 3g, xylitol 10g, arabic gum 3g, hydroxypropyl emthylcellulose 4g, citric acid 10g, sodium bicarbonate 11g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 9:
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 9 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 3 times of 9 times of amounts, and each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 9 times of amounts, 99% ethanol extraction 3 times, and each 0.5～5 hour, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;
C. get above-mentioned dry extract 7g, cyclodextrin inclusion compound 3g, xylitol 8g, arabic gum 4g, hydroxypropyl cellulose 5g, citric acid 12g, boric acid 11g,, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add boric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 10:
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 7 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 5 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 30% ethanol extraction 2 times, and 5 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;
C. get above-mentioned dry extract 5g, cyclodextrin inclusion compound 5g, xylitol 10g, cyclodextrin 6g, citric acid 12g, sodium bicarbonate 11g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 11:
A. get prescription, it is standby with embodiment 1 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3～8 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3～8 times of amounts, and each 1～2 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae be with 3～8 times of amounts, 50～95% ethanol extractions 1～3 time, each 0.5～4 hour, merge extractive liquid,,, reclaim the ethanol concentrated extracting solution to an amount of, drying is pulverized, the dry extract fine powder;
C. with dry extract fine powder 11g and dextrin embedding thing 5g mix homogeneously, lactose 12g, pregelatinized Starch 6g, citric acid 12g, sodium bicarbonate 12g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 12
A. get prescription, it is standby with embodiment 2 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 8 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 8 times of amounts, and each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 8 times of amounts, 95% ethanol extraction 3 times, and each 4 hours, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;
C. get above-mentioned dry extract, cyclodextrin inclusion compound 5g, citric acid 6g, sodium bicarbonate 7g and fully mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 13
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3 times of amounts, and each 1 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracted 0.5 hour with 3 times of amounts, 50% ethanol extraction 1 time, and merge extractive liquid, reclaims ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;
C. get above-mentioned dry extract 4g, cyclodextrin inclusion compound 2g, tartaric acid 10g, sodium bicarbonate 11g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 14
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 5 times of amounts, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 5 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 5 times of amounts, 75% ethanol extraction 2 times, and 4 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol, and concentrated extracting solution is to an amount of, and drying is pulverized, the dry extract fine powder;
C. get above-mentioned dry extract, cyclodextrin inclusion compound 15g, fumaric acid 10g, sodium bitartrate 11g altogether, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 15
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 6 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 2 times, each 1.5 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 2 times with 80% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;
C. get above-mentioned dry extract 8g, cyclodextrin inclusion compound 6g, fumaric acid 20g, sodium bitartrate 25g, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 16
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 3 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 1 time, each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 3 times with 50% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;
C. get above-mentioned dry extract 10g, cyclodextrin inclusion compound 1g, adipic acid 22g, calcium bicarbonate 20g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add adipic acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 17
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 8 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata extracting in water 3 times, each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 1 time with 95% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;
C. get above-mentioned dry extract 35g, cyclodextrin inclusion compound 5g, malic acid 50g, carbonic acid hydrogen clock 60g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add malic acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 18
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. get the recipe quantity Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil is with the betacyclodextrin embedding of 8 times of amounts, aqueous solution after distillation device is in addition collected, the Poria of medicinal residues and all the other recipe quantities, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, the Guangdong Massa Medicata Fermentata adds 3.5 times of water gagings and extracts 3 times, each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection, be concentrated into an amount of, get the Ramulus Uncariae Cum Uncis of recipe quantity again, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae extracts 1 time with 95% concentration ethanol, merge extractive liquid, reclaims ethanol and concentrated extracting solution to an amount of, drying, pulverize, get the dry extract fine powder;
C.. get above-mentioned dry extract 8g, cyclodextrin inclusion compound 2g, boric acid 15g, potassium carbonate 14g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add boric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 19
A. get prescription, it is standby with embodiment 1 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 4 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 4 times of 10 times of amounts, and each 5 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 10 times of amounts, 99% ethanol extraction 4 times, and each 4 hours, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 10g, cyclodextrin inclusion compound 1g, add xylitol 12g, xanthan gum 3g, sodium bicarbonate 30g, starch 10g, citric acid 20g mix homogeneously, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 20
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 7 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 3 times of 2～10 times of amounts, and each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 2 times of amounts, 30% ethanol extraction 3 times, and each 2 hours, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C.. get above-mentioned dry extract 18g, cyclodextrin inclusion compound 2g, boric acid 35g, potassium carbonate 34g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add boric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 21
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 1 times of amount; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 9 times of amounts, and each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 7 times of amounts, 80% ethanol extraction 2 times, and each 1 hour, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 33g, cyclodextrin inclusion compound 4g, malic acid 60g, potassium bicarbonate 70g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add malic acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 22
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 2 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 1 time of 5 times of amounts, extract 4 hours, and the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 5 times of amounts, 50% ethanol extraction 2 times, and each 3 hours, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 12g, cyclodextrin inclusion compound 1g, adipic acid 26g, calcium bicarbonate 20g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add adipic acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 23
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 2.5 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3 times of amounts, and each 1 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 75% ethanol extraction 2 times, and each 1.5 hours, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 6g, cyclodextrin inclusion compound 8g, fumaric acid 20g, sodium bitartrate 25g, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 24
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3.5 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 3 times of 8 times of amounts, and each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 8 times of amounts, 95% ethanol extraction 3 times, and each 3 hours, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract, cyclodextrin inclusion compound 8g, fumaric acid 10g, sodium bitartrate 11g altogether, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 25
A. get prescription, it is standby with embodiment 1 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 4.5 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 8 times of amounts, and each 0.5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 3 times of amounts, 50% ethanol extraction 2 times, and each 0.5 hour, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 6g, cyclodextrin inclusion compound 1g, tartaric acid 10g, sodium bicarbonate 11g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 26
A. get prescription, it is standby with embodiment 2 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 5.5 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 3 times of 5 times of amounts, and each 3 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 5 times of amounts, 65% ethanol extraction 2 times, and each 2 hours, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 2g, cyclodextrin inclusion compound 5g, citric acid 6g, sodium bicarbonate 7g fully mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 27
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 6 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 6 times of amounts, and be each] 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection is concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 6 times of amounts, 90% ethanol extraction 2 times, and each 3 hours, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder 11g and dextrin embedding thing 5g mix homogeneously, lactose 12g, pregelatinized Starch 6g, citric acid 12g, sodium bicarbonate 12g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 28
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 6.5 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3.5 times of amounts, and each 1 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 3.5 times of amounts, 55% ethanol extraction 2 times, and each 1 hour, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 5g, cyclodextrin inclusion compound 5g, xylitol 20g, cyclodextrin 6g, citric acid 22g, sodium bicarbonate 21g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 29
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 7 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 5.5 times of amounts, and each 1.5 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4.5 times of amounts, 60% ethanol extraction 2 times, and each 2.5 hours, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 15g, cyclodextrin inclusion compound 3g, xylitol 18g, arabic gum 14g, hydroxypropyl cellulose 5g, citric acid 12g, boric acid 11g,, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add boric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 30
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 7.5 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3.5～6 times of amounts, and each 2 hours, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 5 times of amounts, 70% ethanol extraction 2 times, and each 2 hours, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 42g, cyclodextrin inclusion compound 3g, xylitol 10g, arabic gum 3g, hydroxypropyl emthylcellulose 4g, citric acid 40g, sodium bicarbonate 41g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 31
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 4 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 4 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 70% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 15g, cyclodextrin inclusion compound 5g, crospolyvinylpyrrolidone 10g, hydroxypropyl emthylcellulose 5g, lactose 14g, sodium bitartrate 16g, tartaric acid 15g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 32
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 4 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 70% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. get above-mentioned dry extract 29g, cyclodextrin inclusion compound 1g, Polyethylene Glycol 28g, hydroxypropyl emthylcellulose 25g, gelatin 24g, sodium bicarbonate 28g, fumaric acid 26g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
The specific embodiment
Embodiment 1:
Get Radix Angelicae Sinensis 6.75g, Rhizoma Chuanxiong 6.75g, Radix Paeoniae Alba 5.4g, Radix Rehmanniae Preparata 5.4g, Ramulus Uncariae Cum Uncis 13.5 weight portions, Caulis Spatholobi 13.5g, Spica Prunellae 13.5g, Semen Cassiae 13.5g, Concha Margaritifera 13.5g, Rhizoma Corydalis 6.75g, Herba Asari 1.34g in proportion, above medicine adds decocting in water 3 times, each 1 hour, collecting decoction concentrated an amount of, the ethanol that adds 2 times of amounts, leave standstill 24 hours precipitations, get supernatant concentration and become cream, relative density is 1.3～1.4, oven dry or spray drying, it is standby that pulverizing obtains medicated powder.
Embodiment 2
Get Radix Angelicae Sinensis 4g, Rhizoma Chuanxiong 4g, Radix Paeoniae Alba 2g, Radix Rehmanniae Preparata 2g, Ramulus Uncariae Cum Uncis 10g, Caulis Spatholobi 10g, Spica Prunellae 10g, Semen Cassiae 10g, Concha Margaritifera 10g, Rhizoma Corydalis 4g, Herba Asari 0.5g in proportion, above medicine adds decocting in water 5 times, each 2 hours, collecting decoction concentrated an amount of, the ethanol that adds 4 times of amounts, leave standstill 18 hours precipitations, get supernatant concentration and become cream, relative density is 1.1～1.5, oven dry or spray drying, it is standby that pulverizing obtains medicated powder.
Embodiment 3
Get Radix Angelicae Sinensis 9g, Rhizoma Chuanxiong 9g, Radix Paeoniae Alba 8g, Radix Rehmanniae Preparata 8g, Ramulus Uncariae Cum Uncis 15g, Caulis Spatholobi 15g, Spica Prunellae 15g, Semen Cassiae 15g, Concha Margaritifera 15g, Rhizoma Corydalis 9g, Herba Asari 2g in proportion, above medicine adds decocting in water 3 times, each 1 hour, collecting decoction concentrated an amount of, the ethanol that adds 2 times of amounts, leave standstill 36 hours precipitations, get supernatant concentration and become cream, relative density is 1.3～1.4, oven dry or spray drying, it is standby that pulverizing obtains medicated powder.
Embodiment 4
Get Radix Angelicae Sinensis 4g, Rhizoma Chuanxiong 9g, Radix Paeoniae Alba 2g, Radix Rehmanniae Preparata 8g, Ramulus Uncariae Cum Uncis 10g, Caulis Spatholobi 15g, Spica Prunellae 10g, Semen Cassiae 15g, Concha Margaritifera 10g, Rhizoma Corydalis 9g, Herba Asari 2g in proportion, above medicine adds decocting in water 3 times, each 0.5 hour, collecting decoction concentrated an amount of, the ethanol that adds 1 times of amount, leave standstill 24 hours precipitations, get supernatant concentration and become cream, relative density is 1.3～1.4, oven dry or spray drying, it is standby that pulverizing obtains medicated powder.
Embodiment 5
(a): it is standby to get embodiment 1 medicated powder 10g, xylitol 12g, xanthan gum 3g, sodium bicarbonate 30g, starch 10g, citric acid 20g;
(b): with medicated powder, xylitol, xanthan gum, sodium bicarbonate, starch, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Execute example 6:
(a): it is standby to get embodiment 1 medicated powder 5g, xylitol 20g, pregelatinized Starch 5g, sodium bicarbonate 25g, starch 9g, citric acid 30g;
(b): with medicated powder, xylitol, pregelatinized Starch, sour hydrogen sodium, starch, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 7:
(a): it is standby to get embodiment 4 medicated powder 15g, xylitol 8g, arabic gum 5g, microcrystalline Cellulose 10g, citric acid 12g, sodium carbonate 14g;
(b): with medicated powder, xylitol, arabic gum, sodium carbonate, starch, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 8
(a): medicated powder 6g, the lactose 15g, Lac 10g, hydroxyethyl-cellulose 20g, pregelatinized Starch 10g, calcium bicarbonate 30g, the tartaric acid 26g that get embodiment 2 method gained are standby;
(b): with medicated powder, lactose, hydroxyethyl-cellulose, Lac, pregelatinized Starch, calcium bicarbonate, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 9
(a): medicated powder 10g, the Polyethylene Glycol 8g, hydroxypropyl emthylcellulose 5g, gelatin 4g, sodium bicarbonate 8g, the fumaric acid 6g that get embodiment 3 method gained are standby;
(b): with medicated powder, Polyethylene Glycol, hydroxypropyl emthylcellulose, gelatin, sodium bicarbonate, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 10
(a): medicated powder 10g, the crospolyvinylpyrrolidone 10g, hydroxypropyl emthylcellulose 5g, lactose 4g, sodium bitartrate 6g, the tartaric acid 5g that get embodiment 4 method gained are standby;
(b): with medicated powder, crospolyvinylpyrrolidone, hydroxypropyl emthylcellulose, lactose, sodium bitartrate, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 11:
(a): medicated powder 25g, the xylitol 10g, arabic gum 3g, hydroxypropyl emthylcellulose 4g, citric acid 10g, the sodium bicarbonate 11g that get embodiment 3 method gained are standby;
(b): with medicated powder, xylitol, arabic gum, sodium bicarbonate, hydroxypropyl emthylcellulose, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 12:
(a): medicine powder 10g, the xylitol 8g, arabic gum 4g, hydroxypropyl cellulose 5g, citric acid 12g, the boric acid 11g that get embodiment 2 method gained are standby;
(b): with medicated powder, xylitol, arabic gum, sodium bicarbonate, hydroxypropyl emthylcellulose, fully mix, drying is sieved, and granulates, and obtains spares; In spares, add boric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 13:
(a): medicine powder 8g, the xylitol 10g, cyclodextrin 6g, citric acid 12g, the sodium bicarbonate 11g that get embodiment 2 method gained are standby;
(b): medicated powder, xylitol, cyclodextrin, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 14:
(a): medicine powder 16g, the lactose 12g, pregelatinized Starch 6g, citric acid 12g, the sodium bicarbonate 12g that get embodiment 1 method gained are standby;
(b): medicated powder, lactose, pregelatinized Starch, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 15:
(a): medicine powder 5g, the citric acid 6g, the sodium bicarbonate 7g that get embodiment 1 method gained are standby;
(b): medicated powder, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 16:
(a): medicine powder 6g, the tartaric acid 10g, the sodium bicarbonate 11g that get embodiment 1 method gained are standby;
(b): medicated powder, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 17:
(a): medicine powder 15g, the fumaric acid 10g, the sodium bitartrate 11g that get embodiment 2 method gained are standby;
(b): medicated powder, sodium bitartrate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 18:
(a): medicine powder 11g, the adipic acid 22g, the calcium bicarbonate 20g that get embodiment 2 method gained are standby;
(b): medicated powder, calcium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add adipic acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 19:
(a): medicine powder 40g, the malic acid 50g, the potassium bicarbonate 60g that get embodiment 2 method gained are standby;
(b): medicated powder, potassium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add malic acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.
Embodiment 20:
(a): medicine powder 10g, the boric acid 15g, the potassium carbonate 14g that get embodiment 2 method gained are standby;
(b): medicated powder, potassium carbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add boric acid, mixing, tabletting is made the effervescent tablet of every 1g, promptly.

Claims (11)

1. one kind has and induces sweat, dry, with in the Chinese medicine effervescent, it is characterized in that it is to be made by following weight portion proportioning raw material: 15.50～55.80 parts of Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss, 105～12000 parts of effervescent adjuvants, described effervescent adjuvant and Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, the Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, the ratio of the gross weight of Semen Coicis extract is 1: 0.1～1, the preparation method of described effervescent comprises the steps, (1) Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, volatile oil gets dextrin embedding thing with the dextrin embedding of 1～10 times of amount; (2) the device collection in addition of the aqueous solution after the distillation; (3) medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 1～4 time of 2～10 times of amounts, and each 0.5～5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; (4) Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 2～10 times of amounts, 30～99% ethanol extractions 1～4 time, and each 0.5～4 hour, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; (5) merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder; (6) with dry extract fine powder, dextrin embedding thing and effervescent adjuvant mixing granulation, tabletting;
Wherein said effervescent adjuvant comprises carbon dioxide source, acid source, disintegrating agent and filler:
Acid source wherein is selected from following more than one adjuvant: fumaric acid, malic acid, boric acid, citric acid;
Carbon dioxide source is selected from following more than one adjuvant: calcium bicarbonate, sodium carbonate, sodium bicarbonate, sodium bitartrate;
The fillibility adjuvant is selected from following more than one adjuvant: Polyethylene Glycol, xylitol, lactose and they contain the water of crystallization chemical compound;
Disintegrating agent is selected from following more than one adjuvant: pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, cyclodextrin, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
2. induce sweat according to claim 1, dry, with in the Chinese medicine effervescent, it is characterized in that it is to be made by following weight portion proportioning raw material: 27.17～41.20 parts of Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss, 105～6700 parts of effervescent adjuvants.
3. induce sweat according to claim 1, dry and in the Chinese medicine effervescent, it is characterized in that it is to be made by following weight portion proportioning raw material: 34.10 parts of Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss, 380～4560 parts of effervescent adjuvants; Wherein the effervescent adjuvant comprises carbon dioxide source, acid source, disintegrating agent and filler:
Acid source wherein is selected from following more than one adjuvant: boric acid, citric acid; Carbon dioxide source is selected from following more than one adjuvant: sodium carbonate, sodium bicarbonate; The fillibility adjuvant is selected from following more than one adjuvant: Polyethylene Glycol, xylitol, lactose; Disintegrating agent is selected from following more than one adjuvant: pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, cyclodextrin, methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
As induce sweat, dry as described in the claim 3 and in the Chinese medicine effervescent, it is characterized in that acid source in the effervescent adjuvant is selected from following more than one adjuvant: citric acid; Carbon dioxide source is selected from following more than one adjuvant: sodium carbonate, sodium bicarbonate; The fillibility adjuvant is selected from following more than one adjuvant: xylitol, lactose; Disintegrating agent is selected from following more than one adjuvant: pregelatinized Starch, modified starch, microcrystalline Cellulose, hydroxypropyl emthylcellulose, hydroxyethylmethyl-cellulose, cyclodextrin, hydroxyethyl-cellulose, hydroxypropyl cellulose.
As induce sweat, dry as described in the claim 4 and in the Chinese medicine effervescent, it is characterized in that the acid source in the effervescent adjuvant is: citric acid; Carbon dioxide source is: sodium bicarbonate; The fillibility adjuvant is selected from following more than one adjuvant: xylitol, lactose; Disintegrating agent is selected from following more than one adjuvant: pregelatinized Starch, cyclodextrin.
6. induce sweat according to claim 1, dry and in the Chinese medicine effervescent, it is characterized in that the effervescent adjuvant and the ratio of the gross weight of Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis extract are 1: 0.1～1: 0.6.
7. induce sweat according to claim 1, dry and in the Chinese medicine effervescent, it is characterized in that the effervescent adjuvant and the ratio of the gross weight of Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis extract are 1: 0.2～1: 0.4.
One kind induce sweat, dry and in the preparation method of Chinese medicine effervescent tablet, comprise the steps:
A. get 15.50～55.80 parts of crude drug Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 1～10 times of amount; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 1～4 time of 2～10 times of amounts, and each 0.5～5 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 2～10 times of amounts, 30～99% ethanol extractions 1～4 time, and each 0.5～4 hour, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder, dextrin embedding thing and effervescent adjuvant mixing granulation, tabletting.
9. induce sweat, dry as claim 8 and in the preparation method of Chinese medicine effervescent tablet, comprise the steps:
A. get 27.17～41.20 parts of crude drug Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3～8 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 1～3 time of 3～8 times of amounts, and each 0.5～3 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 3～8 times of amounts, 50～95% ethanol extractions 1～3 time, and each 0.5～3 hour, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder, dextrin embedding thing and effervescent adjuvant mixing granulation, tabletting.
10. induce sweat, dry as claim 9 and in the preparation method of Chinese medicine effervescent tablet, comprise the steps:
A. it is standby to get 34.10 parts of crude drug Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 3.5～6 times of amounts; Aqueous solution after distillation device is in addition collected; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 3.5～6 times of amounts, and each 1～2 hour, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 3.5～6 times of amounts, 55～90% ethanol extractions 2 times, and each 1～3 hour, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder, dextrin embedding thing and effervescent adjuvant mixing granulation, tabletting.
11. as claim 10 induce sweat, dry and in the preparation method of Chinese medicine effervescent tablet, comprise the steps:
A. it is standby to get 34.10 parts of crude drug Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. wherein the Radix Aucklandiae, Herba Pogostemonis, Exocarpium Citri Grandis, Herba Menthae, Rhizoma Atractylodis use water vapour distillation volatile oil, and volatile oil gets dextrin embedding thing with the dextrin embedding of 4.5 times of amounts; Medicinal residues and Poria, Flos Chrysanthemi, Fructus Tribuli, Fructus Oryzae Germinatus, Semen Coicis, Radix Trichosanthis, Guangdong Massa Medicata Fermentata add the water extraction 2 times of 4 times of amounts, and 2 hours for the first time, 1 hour for the second time, the aqueous solution of merge extractive liquid, and above-mentioned collection was concentrated into an amount of; Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Puerariae, the Radix Angelicae Dahuricae are with 4 times of amounts, 70% ethanol extraction 2 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, reclaimed ethanol, and extracting solution is concentrated in right amount; Merge above-mentioned concentrated solution, drying is pulverized, and gets the dry extract fine powder;
C. with dry extract fine powder, dextrin embedding thing and effervescent adjuvant mixing granulation, tabletting.
CN200610011171XA 2006-01-12 2006-01-12 Traditional Chinese medicine effervescent tablets for inducing sweat, cleaning damp and harmonizing middle-jiao, and its preparing method Active CN100998776B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN200610011171XA CN100998776B (en) 2006-01-12 2006-01-12 Traditional Chinese medicine effervescent tablets for inducing sweat, cleaning damp and harmonizing middle-jiao, and its preparing method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN200610011171XA CN100998776B (en) 2006-01-12 2006-01-12 Traditional Chinese medicine effervescent tablets for inducing sweat, cleaning damp and harmonizing middle-jiao, and its preparing method

Publications (2)

Publication Number Publication Date
CN100998776A CN100998776A (en) 2007-07-18
CN100998776B true CN100998776B (en) 2011-06-22

Family

ID=38257648

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200610011171XA Active CN100998776B (en) 2006-01-12 2006-01-12 Traditional Chinese medicine effervescent tablets for inducing sweat, cleaning damp and harmonizing middle-jiao, and its preparing method

Country Status (1)

Country Link
CN (1) CN100998776B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102370833B (en) * 2010-08-17 2014-03-26 北京亚东生物制药有限公司 Effervescent agent for exterior syndrome relieving and summer heat dispelling, preparation method thereof and purpose thereof
CN106858029B (en) * 2017-02-17 2020-05-22 上海市第七人民医院 Chewing gum containing coix seeds and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1583086A (en) * 2004-05-27 2005-02-23 广州王老吉药业股份有限公司 Chinese medicine for relieving exterior syndrome, regulating stomach and eliminatnig dampness and its production

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1583086A (en) * 2004-05-27 2005-02-23 广州王老吉药业股份有限公司 Chinese medicine for relieving exterior syndrome, regulating stomach and eliminatnig dampness and its production

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
田秀峰等.中药泡腾片及工艺研究进展.《中国中药杂志》.2004,第29卷(第7期), *
药典委员会.保济丸.《中华人民共和国卫生部药品标准中药成方制剂第二十册》.1998,第194-195页. *
药典委员会.保济口服液.《中华人民共和国卫生部药品标准中药成方制剂第十七册》.1998,第171-172页. *

Also Published As

Publication number Publication date
CN100998776A (en) 2007-07-18

Similar Documents

Publication Publication Date Title
CN102895432A (en) Prescription and preparation method of rejoicing powder having new dosage form
CN100425227C (en) Chinese medicine for relieving exterior syndrome, regulating stomach and eliminatnig dampness and its production
CN104055871A (en) Traditional Chinese medicinal composition for improving sleeping quality and application of traditional Chinese medicinal composition
CN102293936B (en) Medicinal composition or health food composition for protecting gastric mucosa, and preparation method thereof
CN100998787B (en) Traditional Chinese medicine effervescent tablets for treating gastrointestinal disease and its preparing method
CN100998776B (en) Traditional Chinese medicine effervescent tablets for inducing sweat, cleaning damp and harmonizing middle-jiao, and its preparing method
CN104474472A (en) Broadleaf holly leaf buccal tablet capable of reducing high blood pressure, high blood lipid and high blood glucose and production method of buccal tablet
CN100998780B (en) Traditional Chinese medicine dripping pills for relieving exterior syndrome, removing dampness regulating the stomach and its preparing method
CN102441064B (en) Traditional Chinese medicine composition for treating diabetes and preparation thereof
CN101461925B (en) Medicament composition for treating hepatopathy and preparation method thereof
CN1985944A (en) Chinese medicine composition for treating cutaneous pruritus, rubella and other diseases
CN100551425C (en) A kind of Chinese medicine composition composition dispersible tablets for the treatment of gastrointestinal disease and preparation method thereof
CN100998781B (en) Traditional Chinese medicine capsule for relieving exterior syndrome, removing dampness regulating the stomach and its preparing method
CN100998784B (en) Preparing method of traditional Chinese medicine composition tablet for treating gastrointestinal disease
CN100998783B (en) Traditional Chinese medicine composition capsule for treating gastrointestinal disease and its preparing method
CN100998777B (en) Traditional Chinese medicine capsule for inducing sweat, cleaning damp and harmonizing middle-jaio, and its preparing method
CN100551426C (en) A kind of induce sweat, dry and in dispersible tablets of Chinese medicine and preparation method thereof
CN100998778B (en) Traditional Chinese medicine tablets for relieving exterior syndrome, removing dampness regulating the stomach and its preparing method
CN100998779B (en) Traditional Chinese medicine granule for relieving exterior syndrome removing dampness and regulating the stomach and its preparing method
CN101264171A (en) Chinese medicine composition for drug detoxification and preparation and application thereof
CN100563634C (en) A kind of Herba Sidae Rhombifoliae soup drop pill
CN104189833A (en) Process for preparing xiaoyao pills
CN100998786B (en) Traditional Chinese medicine composition granule for treating gastrointestinal disease and its preparing method
CN100998788B (en) Traditional Chinese medicine composition dripping for treating gastrointestinal disease and its preparing method
CN103565956B (en) Traditional Chinese medicine composition for treating diabetes and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant