CN103565956B - Traditional Chinese medicine composition for treating diabetes and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating diabetes and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating diabetes and a preparation method and application thereof. The composition is prepared from the following raw material medicines in parts by weight: 5-10 parts of ginseng stem and leaf saponins, 8-12 parts of red ginseng and 8-12 parts of coptis chinensis. The composition has an obvious effect of reducing blood sugar and blood fat.
Description
Technical field
The present invention relates to field of medicaments, especially relate to a kind of Chinese medicine composition and preparation thereof for the treatment of diabetes.
Background technology
" diabetes " refer to polydipsia, polyuria, polyphagia and become thin, tired, to urinate sweet be the syndrome of cardinal symptom, this disease is a kind of commonly encountered diseases, its sickness rate has the trend increasing in recent years, especially person in middle and old age fall ill more." more than three " and the degree of becoming thin are the important symbols of judgement state of an illness weight.Should be by changing lifestyles after discovery, comprise keep on a diet, physical training and losing weight, and coordinate certain Drug therapy, to reach the object of controlling the state of an illness.In addition, easily there is another feature that many complication are primary disease.The key factor that complication affects the state of an illness, damage patient labour force and jeopardizes patient's life, therefore should pay close attention to treatment and prevention.
Modern medicine is generally divided into for the medicine of diabetes: 1, ureas-gliclazide etc., and mechanism of action, stimulates insulin β cell to discharge and excreting insulin, is that blood sugar level reduces rapidly untoward reaction: the exhaustion of β cell function; Hypoglycemia etc.2, biguanides-metformin hydrochloride, mechanism of action: delay glucose sugar in the absorption of intestinal, untoward reaction: feel sick, the gastrointestinal reaction such as vomiting; Lactic acidosis etc.3, dry enzyme inhibitor-acarbose of phlorose etc., mechanism of action: delay digestive tract to sugared absorption.Untoward reaction: gastrointestinal upset, feel sick, diarrhoea etc.4, the happy safe capsule of Chinese traditional treatment-perseverance Ji etc., mechanism of action: regulate insulin secretion function, protect the liver and protect kidney, regulate internal organs metabolism etc., untoward reaction: have no side effect, but it is slow to take effect.The indication of above-mentioned western medicine diabetes reduces blood glucose, but its index do not effect a permanent cure, and with respect to Chinese medicine to really fundamentally obtaining medical treatment in the treatment of diabetes.
In prior art, treatment by Chinese herbs diabetes is all generally large prescription, and flavour of a drug reach tens kinds or tens of kinds, is that production cost or patient's consumer cost are all high, the more important thing is that patient's anaclisis is poor, thereby affects the treatment.For example CN102028811A discloses a kind of Chinese medicine composition for the treatment of diabetes, it is characterized in that adopting the crude drug of following weight portion to make: 25～35 parts of the Radixs Astragali, 10～25 parts of Radix Pseudostellariaes, 10～25 parts of Radix Rehmanniae, 10～20 parts of Semen Litchis, 10～20 parts of Radix Salviae Miltiorrhizaes, 5～10 parts of Hirudos, CN02416112A Chinese medicine composition for the treatment of diabetes, it is characterized in that: its raw material of Chinese medicine by following weight portion proportioning forms: 5～25 parts of the Rhizoma Pinelliaes, 5～25 parts of Pericarpium Citri Reticulataes, Poria 5～25 is expected, 5～20 parts of Fructus Aurantii Immaturuss, 5～25 parts of Arisaema Cum Bile, 10～30 parts of Concretio Silicea Bambusaes, 5～25 parts of Fructus Gardeniaes, Rhizoma Coptidis 5～25 is expected, 5～25 parts of Semen Cuscutae, 5～25 parts of Fructus Rubies, 5～25 parts of Semen Plantaginiss, 3～10 parts of Radix Glycyrrhizae Preparatas.
Summary of the invention
In order to address the above problem, to the invention provides and a kind ofly write out a prescription that simple essence is little, the Chinese medicine composition of the treatment diabetes of determined curative effect.
The present invention also provides the preparation method of said composition.
The present invention also provides said composition to make acceptable preparation on medicament.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine composition for the treatment of diabetes of the present invention, it is to be made by the crude drug of following weight parts proportioning: stem and leaf of Radix Ginseng saponin 5-10 part, Radix Ginseng Rubra 8-12 part, Rhizoma Coptidis 8-12 part.
Preferably, Chinese medicine composition of the present invention, it is to be made by the crude drug of following weight parts proportioning:
Stem and leaf of Radix Ginseng saponin 7-9 part, Radix Ginseng Rubra 9-11 part, Rhizoma Coptidis 9-11 part.
Most preferably, Chinese medicine composition of the present invention, it is to be made by the crude drug of following weight parts proportioning: 8 parts of stem and leaf of Radix Ginseng saponin, 10 parts of Radix Ginseng Rubra, 10 parts of Rhizoma Coptidis.
Chinese medicine composition of the present invention, described Radix Ginseng Rubra can use Radix Ginseng, Radix Panacis Quinquefolii to replace, and stem and leaf of Radix Ginseng saponin can replace with Radix Ginseng saponin.
The present invention also provides the preparation method of this Chinese medicine composition, and inventor filters out through a large amount of test and experiences, comprises the steps:
(1) get stem and leaf of Radix Ginseng saponin 5-10 part, Radix Ginseng Rubra 8-12 part, Rhizoma Coptidis 8-12 part of weight portion;
(2) Radix Ginseng Rubra, company's Huang add respectively 6-10 times of decocting and boil 1-3 time, time 1-3 hour, and merging filtrate, concentrated, dry, pulverize to obtain powder;
(3) above-mentioned powder and stem and leaf of Radix Ginseng saponin mix.
Wherein, in above-mentioned steps (1), Chinese medicine composition preferably ginseng stem leaf saponin 7-9 part, Radix Ginseng Rubra 9-11 part, Rhizoma Coptidis 9-11 part; Optimally, choose 8 parts of ginseng stem leaf saponins, 10 parts of Radix Ginseng Rubra, 10 parts of Rhizoma Coptidis.
Stem and leaf of Radix Ginseng saponin described in Chinese medicine composition of the present invention can buy or extract voluntarily in market, and described stem and leaf of Radix Ginseng saponin's content is not less than 75%, and content must can be used as medicine not after purification.Described stem and leaf of Radix Ginseng saponin extracts and purification process includes but not limited to: solvent extraction, solvent precipitation, magnesium oxide adsorbing method, lead salt precipitation, chromatography etc.Described solvent extraction: by ginsenoside's aqueous solution or dilute alcohol solution, add saline solution saturated, then with water saturated butanols or amylalcohol repeatedly extracting to extract evaporate to dryness, merge extract, wash with water, after decompression and solvent recovery total saponins.Described solvent precipitation refers to that the character of utilizing saponin difficulty to be dissolved in acetone and ether equal solvent adds the thick saponin proposing in the mixed solvent of acetone-ether in a small amount of methanol or ethanol and can separate out saponin, and then obtains purer saponin with buchner funnel suction strainer.Described magnesium oxide adsorbing method refers to the thick saponin of alcohol extraction, often contain the impurity such as a large amount of sugar, tannin and pigment, the magnesium oxide adsorbing making after the oxidized magnesium calcined dehydration of these impurity, then in apparatus,Soxhlet's with methanol or ethanol extracting, concentrated extract, can obtain purer saponin.Described lead salt precipitation refers to: in the water or alcoholic solution of thick saponin, add neutral lead acetate solution to precipitate acid saponin, till no longer including Precipitation, leach precipitation; Filtrate is being precipitated neutral saponin with Lead monosubacetate, deleading according to a conventional method in water or rare alcohol, leaches clear liquid later, concentrating under reduced pressure and get final product.Described chromatography comprises alumina column chromatography, silica gel column chromatography, polyamide chromatography, activated carbon chromatography, ion-exchange chromatography, thin layer chromatography and column chromatography etc.The preferred macroporous resin chromatography of described ion-exchange chromatography, macroporous resin model of the present invention includes but not limited to: AB-8 post, D101 post, D201 post, D301 post, HPD100 post, HPD300 post, HPD600 post, NKA-9 post, DA201 type, D-type, SIP series, X-5 type, GDX104 type, LD605 type, LD601 type, CAD-40 type, DM-130 type, R-A type, CHA-111 type, WLD type (mixed type), H107 type etc., preferred D101 type, AB-8 type, best D101 type.
The preferred 4-6 of stem and leaf of Radix Ginseng saponin of the present invention is raw, and Stem and leaf of Radix Ginseng extracts through resin method, and described Stem and leaf of Radix Ginseng can extract for Radix Ginseng, Flos Ginseng, ginseng seed or Radix Ginseng herb.The Chinese crude drug that described Radix Ginseng can contain the compositions such as Ginsenosides with Radix Panacis Quinquefolii, Radix Ginseng Rubra or Radix Notoginseng etc. replaces or exchanges, and the constant effect of preparation method is constant.
Preferably, in step of the present invention (2), Rhizoma Coptidis, Radix Ginseng Rubra decoct with water 3 times, 8,8,6 times of amount of water, and 2,2,1 hours time, gradation is filtered, and merging filtrate is concentrated, dry, pulverize.Described extractum is concentrated into relative density 1.000-1.250, preferably 1.150-1.200.
Due to Radix Ginseng, master quenches one's thirst, that the classical medical works of motherland carries altogether, ancient Chinese medicine doctor is clinical is main with Radix Ginseng mainly with compound decoction, the active component of study of pharmacy in modern age Radix Ginseng treatment diabetes is ginsenoside, para-insulin material, adenosine and polypeptide etc., and with Rhizoma Coptidis and Radix Ginseng 5 use, can make ginsenoside's composition be easy to, by flooding, make increased activity.
Preferably, in step of the present invention (3), above-mentioned powder increases progressively and mixes with stem and leaf of Radix Ginseng saponin's equivalent, and because the dry viscosity of Radix Ginseng Rhizoma Coptidis extract is stronger, equivalent increases progressively mixing method can mix homogeneously, the good evenness of medicine.
The present invention also provides the Chinese medicinal components with blood coagulation resisting function to make pharmaceutically acceptable preparation or as the active component of pharmaceutical composition.This component shared percentage by weight in preparation can be 0.1～99.9%, and all the other are medicine acceptable carrier, according to preparation conventional method, prepares.
Component of the present invention, when being prepared into medicament, optionally add applicable medicine acceptable carrier, described medicine acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Component of the present invention, its pharmaceutical dosage forms can be any oral formulations or injection.Wherein oral formulations includes but not limited to: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, oral cavity disintegration tablet, granule.Electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, drop pill, pellet, suppository, cream, spray etc.; Injection includes but not limited to: intravenous injection, injectable powder, subcutaneous injection agent etc.Preferred formulation capsule of the present invention, preferably Rhizoma Coptidis, Radix Ginseng Rubra extractum powder and stem and leaf of Radix Ginseng saponin mix rear 95% alcohol granulation of using, and make capsule.
The present invention is the treatment to " diabetes " in accordance with motherland's medical science, principle: take Radix Ginseng as principal agent in the prescription side that the theory of " quench the thirst and moisturize; heat clearing away QI invigorating " forms, and assistant is with number taste Chinese medicines such as Rhizoma Coptidis, to only reaching, quench one's thirst, the effect of heat clearing away tonification. existing by its pharmacodynamic study, proof beneficial effect of the present invention is described.
Test example one
Animal: rat, Wistar kind, 130 ± 10 grams of body weight.White mice, Kunming kind, 20 ± 2.0 grams of body weight.Animal all adopts random packet, and male and female are impartial as far as possible.All animals is purchased from Norman Bethune Medical University, Changchun animal portion, and animal all meets the grade animal requirement of national regulation.
Reagent: adrenalin hydrochloride, Mingxing Pharmaceutical Factory, Guangzhou is produced, lot number: 920818.Alloxan, Britain, BDH company limited produces, lot number: 420110 insulins, glucagon medicine box, U.S. Depew company manufactures.The biochemical automatic analyzer of instrument: RA-1000, the manufacture of U.S. Tai Er Kanggong department.
Medicine of the present invention: (call in the following text: medicine of the present invention) according to the method preparation of implementing one.
Contrast medicine: glyburide (glibenclamide), Shanghai the 2nd Shi Yi pharmaceutical factory produces.
Method and result:
One, medicine of the present invention is on the glycometabolic impact of laboratory animal
1, the impact on the sick mouse blood sugar level of epinephrine glycosuria
Select 48 of mices.Grouping and dosage are in Table 1.Each treated animal gastric infusion every day (lower same) 2 times.Administration is 14 times altogether.Normal group mice is to equal-volume water (lower same).After last administration 15 minutes, except normal group, all in subcutaneous injection epinephrine 20ug/kg once.Inject latter 30 minutes, by sacrifice of animal, blood sampling, gets serum, according to ortho-aminotoluene method, surveys blood glucose value.The results are shown in Table 1.
Table 1, the impact on the sick mouse blood sugar level of epinephrine glycosuria
Table 1 shows, " medicine of the present invention " can make the hyperglycemia of the sick mice of epinephrine glycosuria obviously reduce, and with the comparison of hyperglycemia matched group, learns by statistics and processes obvious difference.Action intensity and positive control medicine glyburide are without significant difference.
2, the preventive effect to alloxan diabetes mice
Select 50 of mices, grouping and dosage are in Table 2.Administration every day 2 times, in the 7th day, except Normal group, remaining group of mice by tail vein note alloxan 60mg/kg once.Continue administration three days, put to death animal, blood sampling, gets serum, surveys blood sugar level.The results are shown in Table 2.
Table 2, the preventive effect to alloxan diabetes mice
Result shows, mice takes the generation that " medicine of the present invention " can prevent alloxan diabetes in advance.
3, the therapeutical effect to mice alloxan diabetes
Select 43 of mices, grouping and dosage are in Table 3.Except Normal group, by tail vein injection alloxan once, on the same day after injection, administration every day 2 times, altogether to 6 times for remaining group of mice.Note alloxan after 72 hours by sacrifice of animal.Blood sampling, gets serum, surveys blood glucose value, the results are shown in Table 3.
Table 3, the therapeutical effect to alloxan glycosuria pain mice
Result shows, " medicine of the present invention " (500mg/kg) has therapeutical effect to mice alloxan diabetes.
The therapeutical effect of 4, alloxan diabetes mice being stopped using after medicine of the present invention
Select 47 of mices, grouping and dosage are in Table 4.Except Normal group, remaining group of mice be the same day after tail vein injection alloxan is once penetrated all, and administration every day 2 times, altogether to 8 times.Within the 5th day, by sacrifice of animal, blood sampling, gets serum in then drug withdrawal, surveys blood sugar level, in Table 4.
Therapeutical effect after table 4 pair alloxan diabetes mice drug withdrawal
Result shows, to alloxan diabetes mice, in inactive medicine of the present invention day after tomorrow, blood glucose is still lower than experiment contrast mice: wherein the blood glucose value with 500mg/kg amount group reduces the most obviously, and prompting " medicine of the present invention " has curative effect effect.
5, the impact on hyperosmotic glucose load rat blood sugar level
Select 39 of rats, grouping is with dosage in Table 5, and every day 2 times, altogether to 14 times, after last administration 30 minutes, except Normal group, the equal lumbar injection 40% glucose 1.5g/kg of remaining treated animal, within 60,120 minutes after injection, take a blood sample once respectively, survey blood sugar level, result table 5.
The impact of table 5 on hyperosmotic glucose load rat blood sugar level
P value * < 0.05, * * < 0.02, * * * < 0.01, * * * * < 0.0001
Result shows, " medicine of the present invention " has the blood glucose value reducing effect that makes hyperosmotic glucose load rat; This work is the most obvious in order to 500mg/kg dosage.Effect not existing fast (beginning for 30 minutes aobvious), and more remarkable after can extending to 120 minutes, contrast medicine glyburide only produced obvious depression effect in the time of 120 minutes.
6, the impact on the blood sugar level of islets of langerhans disposition hypoglycemia mice
Select 37 of mices.Grouping and dosage are in Table 6, administration every day 2 times, totally 14 times, after last administration 15 minutes, except Normal group, the remaining equal subcutaneous injection 40% glucose 0.2ml/kg of treated animal once, once in the subcutaneous insulin injection again of another side 2u/kg simultaneously, injects and within latter 30 minutes, puts to death animal, blood sampling, get serum, survey blood sugar level, the results are shown in Table 6.
The impact of table 6 on the capable hypoglycemia mouse blood sugar of insulin level
Result shows: medicine of the present invention has the effect of the blood sugar level rebound significantly that makes islets of langerhans disposition hypoglycemia mice: present blood sugar level two-way regulating function.
Two, " medicine of the present invention " is on the lipometabolic impact of laboratory animal
1, the impact on the sick lipid of mice level of epinephrine glycosuria
Select 40 of mices.Grouping and dosage are in Table 7.Administration every day 2 times, altogether to 14 times.After last administration 15 minutes, except Normal group, each organized the equal subcutaneous injection epinephrine of mice 20ug/kg once.Inject blood sampling in latter 30 minutes, get serum, survey blood glucose and confirm after hyperglycemia model success, then row is measured triglyceride level.The results are shown in Table 7.
The impact of table 7 on the sick lipid of mice level of epinephrine glycosuria
Result shows, " medicine of the present invention " can reduce that the sick mice of epinephrine glycosuria follows blood sugar increasing and the level of the hyperlipidemia that occurs significantly.
2, the impact on hyperlipemia mice
Select 40 of mices.Grouping and dosage are in Table 8; Administration is 7 days altogether, every day 2 times.In the time of the 6th day, except Normal group, each only organizes the fresh egg yolk emulsion of the equal lumbar injection of mice 0.5ml/.Inject latter 20 hours, blood sampling, gets serum, surveys cholesterol (TCH), triglyceride (TG) level.The results are shown in Table 8.
The impact of table 8 on hyperlipemia in mice blood lipid level
Result shows: " medicine of the present invention " can make the blood lipid level of hyperlipemia in mice obviously reduce, and presents effect for reducing blood fat.
Three, on the endocrine impact of diabetic animal
1, the impact on insulin and Plasma Glucagon Level in the sick Mouse Blood of epinephrine glycosuria
Select 40 of mices.Grouping and dosage are in Table 9.Administration every day 2 times, altogether to 14 times.After last administration 15 minutes, except Normal group, each organized the equal subcutaneous injection epinephrine of mice 20ug/kg once.Inject blood sampling in latter 30 minutes, get serum, survey blood glucose and confirm after hyperglycemia model success, then measure insulin level in serum with putting the method for exempting from, the results are shown in Table 9.
The impact of table 9 on insulin and Plasma Glucagon Level in the sick Mouse Blood of epinephrine glycosuria
Result shows: medicine of the present invention can make insulin level in adrenaline-induced hyperglycosemia rats blood obviously raise, but on insulinemia sugar level in its blood without affecting.
2, the impact on insulin and Plasma Glucagon Level in alloxan diabetes Mouse Blood
Select 39 of mices.Grouping and dosage are in Table 10.Administration every day 2 times, altogether to 10 times.In the 7th day, except Normal group, remaining group of mice by tail vein note alloxan 60mg/kg once.Inject latter 72 hours, blood sampling, gets serum, surveys blood glucose and confirms to measure insulin and Plasma Glucagon Level in serum after model success again.The results are shown in Table 10.
The impact of table 10 on insulin in alloxan diabetes Mouse Blood and Plasma Glucagon Level
Result shows: " medicine of the present invention " can make insulin level in alloxan diabetes Mouse Blood raise, wherein obvious with 500mg/kg dosage, but Plasma Glucagon Level in blood is had no significant effect.
Conclusion: the pharmacodynamics test of " medicine of the present invention " confirms, the adrenal gland disposition of medicine of the present invention to animal.The formation of the experimental hyperglycemia such as alloxan and bait all has resistance inhibitor action significantly.Under condition, when dosage is 250mg/kg, 500mg/kg, the effect of high dose group is more obvious.To alloxan diabetes mice, " medicine of the present invention " existing preventive effect has again remarkable therapeutical effect.With the comparison of positive control drug glyburide, drug effect of the present invention is effective soon.
The specific embodiment
By the specific embodiment below, explaining content of the present invention, is not the further restriction to protection domain of the present invention.
embodiment 1
Get stem and leaf of Radix Ginseng saponin 80g, Radix Ginseng Rubra 100g, Rhizoma Coptidis 100g, above three tastes, Radix Ginseng Rubra, Rhizoma Coptidis decoct with water respectively three times, 8,8,6 times of amount of water, time is 2,2,1 hours, and gradation is filtered, and filtrate merges, and is concentrated into appropriate, dry, pulverize, add stem and leaf of Radix Ginseng saponin to mix, obtain compositions.
embodiment 2
Get stem and leaf of Radix Ginseng saponin 50g, Radix Ginseng Rubra 120g, Rhizoma Coptidis 80g, above three tastes, Radix Ginseng Rubra, Rhizoma Coptidis decoct with water respectively three times, 6 times of amount of water, time is 2 hours, filters, and filtrate merges, and is concentrated into appropriate, dry, pulverize, add stem and leaf of Radix Ginseng saponin to mix, obtain compositions.
embodiment 3
Get stem and leaf of Radix Ginseng saponin 100g, Radix Ginseng Rubra 100g, Rhizoma Coptidis 100g, above three tastes, Radix Ginseng Rubra, Rhizoma Coptidis decoct with water respectively three times, 8,8,6 times of amount of water, time is 2,2,1 hours, and gradation is filtered, and filtrate merges, and is concentrated into appropriate, dry, pulverize, add stem and leaf of Radix Ginseng saponin to mix, obtain compositions.
embodiment 4
Get stem and leaf of Radix Ginseng saponin 90g, Radix Ginseng Rubra 90g, Rhizoma Coptidis 110g, above three tastes, Radix Ginseng Rubra, Rhizoma Coptidis decoct with water respectively three times, 8,8,6 times of amount of water, time is 2,2,1 hours, and gradation is filtered, and filtrate merges, and is concentrated into appropriate, dry, pulverize, add stem and leaf of Radix Ginseng saponin to mix, obtain compositions.
embodiment 5
Get stem and leaf of Radix Ginseng saponin 80g, Radix Ginseng Rubra 110g, Rhizoma Coptidis 90g, above three tastes, Radix Ginseng Rubra, Rhizoma Coptidis decoct with water respectively three times, 8,8,6 times of amount of water, time is 2,2,1 hours, and gradation is filtered, and filtrate merges, and is concentrated into appropriate, dry, pulverize, add stem and leaf of Radix Ginseng saponin to mix, obtain compositions.
embodiment 6
Get stem and leaf of Radix Ginseng saponin 70g, Radix Ginseng Rubra 100g, Rhizoma Coptidis 110g, above three tastes, Radix Ginseng Rubra, Rhizoma Coptidis decoct with water respectively three times, 8,8,6 times of amount of water, time is 2,2,1 hours, and gradation is filtered, and filtrate merges, and is concentrated into appropriate, dry, pulverize, add stem and leaf of Radix Ginseng saponin to mix, obtain compositions.
embodiment 7
Get stem and leaf of Radix Ginseng saponin 80g, Radix Ginseng Rubra 100g, Rhizoma Coptidis 100g, above three tastes, Radix Ginseng Rubra, Rhizoma Coptidis decoct with water respectively three times, 10 times of amount of water, time is 1-3 hour, and gradation is filtered, and filtrate merges, and is concentrated into appropriate, dry, pulverize, add stem and leaf of Radix Ginseng saponin's equivalent to increase progressively and mix, obtain compositions.
embodiment 8
Get Radix Ginseng saponin 80g, Radix Ginseng Rubra 100g, Rhizoma Coptidis 100g, above three tastes, Radix Ginseng Rubra, Rhizoma Coptidis decoct with water respectively three times, 6 times of amount of water, time is 2 hours, and gradation is filtered, and filtrate merges, and is concentrated into appropriate, dry, pulverize, add stem and leaf of Radix Ginseng saponin to mix, obtain compositions.
embodiment 9
Get arasaponin 80g, Radix Ginseng Rubra 100g, Rhizoma Coptidis 100g, above three tastes, Radix Ginseng Rubra, Rhizoma Coptidis decoct with water respectively three times, 8,8,6 times of amount of water, time is 2,2,1 hours, and gradation is filtered, and filtrate merges, and is concentrated into appropriate, dry, pulverize, add stem and leaf of Radix Ginseng saponin to mix, obtain compositions.
embodiment 10
Get Radix Panacis Quinquefolii saponin 80g, Radix Ginseng Rubra 100g, Rhizoma Coptidis 100g, above three tastes, Radix Ginseng Rubra, Rhizoma Coptidis decoct with water respectively three times, 8,8,6 times of amount of water, time is 2,2,1 hours, and gradation is filtered, and filtrate merges, and is concentrated into appropriate, dry, pulverize, add stem and leaf of Radix Ginseng saponin to mix, obtain compositions.
embodiment 11, granule
Get any extractum 100g of embodiment 1-5, add respectively the dextrin of 1.5 times of amounts, 0.5% sucrose, 1.5% microcrystalline Cellulose, makes soft material with appropriate dissolve with ethanol, granulates, 60 ℃ of forced air dryings 12, drop pill
Get any extractum 100g of embodiment 1-5, add the Polyethylene Glycol of 1000g, mix homogeneously, melting, upper pill dripping machine, makes drop pill.
embodiment 13, oral cavity disintegration tablet
Get any extractum 100g of embodiment 1-5, add 5% polyvinylpolypyrrolidone, 0.1% magnesium stearate, 50% microcrystalline Cellulose, makes soft material with appropriate alcoholic solution, granulates, and 60 ℃ of forced air dryings, granulate, granulate, compacting in flakes, obtains oral cavity disintegration tablet.
embodiment 14, injectable powder
Get any extractum 0.5g of embodiment 1-5, glucose 4.5g, sodium thiosulfate 0.9g and distilled water 1ml, after said components mix homogeneously, lyophilization, 500 of subpackages, obtain injectable powder.
embodiment 15, tablet
Get any extractum 100g of embodiment 1-5, with starch, sodium carboxymethyl cellulose, Pulvis Talci mix homogeneously, granulate, and tabletting obtains tablet.
embodiment 16, oral liquid
Get any extractum 2g of embodiment 1-5, with syrup 4g, be dissolved in the pure water of 100ml, homogenizing, filters, through high-temperature short-time sterilization (135 ℃, 4s).Sterile filling, subpackage.Make oral liquid.
Group component within the scope of above-described embodiment and description can expand or reduce in scale according to need of production simultaneously.
Claims (9)
1. treat a Chinese medicine composition for diabetes, it is to be made by the crude drug of following weight parts proportioning:
Stem and leaf of Radix Ginseng saponin 5-10 part, Radix Ginseng Rubra 8-12 part, Rhizoma Coptidis 8-12 part, described stem and leaf of Radix Ginseng saponin selects the raw Stem and leaf of Radix Ginseng of 4-6 to prepare through resin method, and described saponin content is not less than 75%.
2. Chinese medicine composition as claimed in claim 1, it is to be made by the crude drug of following weight parts proportioning:
Stem and leaf of Radix Ginseng saponin 7-9 part, Radix Ginseng Rubra 9-11 part, Rhizoma Coptidis 9-11 part.
3. Chinese medicine composition as claimed in claim 1, it is to be made by the crude drug of following weight parts proportioning: 8 parts of stem and leaf of Radix Ginseng saponin, 10 parts of Radix Ginseng Rubra, 10 parts of Rhizoma Coptidis.
4. the Chinese medicine composition as described in claim 1-3 any one, is characterized in that, described Radix Ginseng Rubra can use Radix Ginseng, Radix Panacis Quinquefolii, Radix Notoginseng to replace, and stem and leaf of Radix Ginseng saponin can replace with Radix Ginseng saponin.
5. a preparation method for the treatment of the Chinese medicine composition of diabetes, is characterized in that, comprises the steps:
(1) get stem and leaf of Radix Ginseng saponin 5-10 part, Radix Ginseng Rubra 8-12 part, Rhizoma Coptidis 8-12 part of weight portion;
(2) Radix Ginseng Rubra, company's Huang add respectively 6-10 times of decocting and boil 1-3 time, time 1-3 hour, and merging filtrate, concentrated, dry, pulverize to obtain powder;
(3) above-mentioned powder and stem and leaf of Radix Ginseng saponin mix,,
Described stem and leaf of Radix Ginseng saponin selects the raw Stem and leaf of Radix Ginseng of 4-6 to prepare through resin method, and described saponin content is not less than 75%.
6. preparation method as claimed in claim 5, is characterized in that: in described step (2), Rhizoma Coptidis, Radix Ginseng Rubra decoct with water 3 times, 8,8,6 times of amount of water, and the time is 2,2,1 hours, and gradation is filtered, and merging filtrate is concentrated, dry, pulverize.
7. preparation method as claimed in claim 5, is characterized in that: in described step (3), above-mentioned powder increases progressively and mixes with stem and leaf of Radix Ginseng saponin's equivalent.
8. preparation method as claimed in claim 5, is characterized in that, in described step (2), extractum is concentrated into relative density 1.000-1.250.
9. the Chinese medicine composition as described in claim 1-3 any one is made acceptable preparation on medicament.
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| 中医药治疗消渴病用药规律研究;郭军锋，等;《陕西中医学院学报》;20110531;第34卷(第3期);第58-60、65页 * |
| 单因素考察人参黄连药对有效组分配伍对α-葡萄糖苷酶的影响;唐姗，等;《吉林中医药》;20120229;第32卷(第2期);第192-194页 * |
| 抗饥消渴片质量标准研究;韩勇，等;《中国药业》;20050430;第14卷(第8期);第24-25页 * |
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