CN101450162A - Traditional Chinese medicine composition with blood-sugar reduction function and preparation method thereof - Google Patents
Traditional Chinese medicine composition with blood-sugar reduction function and preparation method thereof Download PDFInfo
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- CN101450162A CN101450162A CNA2007101785080A CN200710178508A CN101450162A CN 101450162 A CN101450162 A CN 101450162A CN A2007101785080 A CNA2007101785080 A CN A2007101785080A CN 200710178508 A CN200710178508 A CN 200710178508A CN 101450162 A CN101450162 A CN 101450162A
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- chinese medicine
- medicine composition
- fructus momordicae
- tea polyphenols
- momordicae charantiae
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Abstract
The invention discloses a traditional Chinese medicine composition with hypoglycemic function and preparation method thereof. The traditional Chinese medicine is made from balsam pear, Chinese yam and tea polyphenol according to a certain weight proportion; and it can be made into any common oral taken preparation form. The Chinese traditional medicine composition in the invention achieves hypoglycemic function, and can be used in auxiliary treatment of diabetes.
Description
Technical field
The wood invention relates to a kind of Chinese medicine composition with function of blood sugar reduction and preparation method thereof, belongs to Chinese medicine and field of health care food.
Background technology
Diabetes are the one group of Developmental and Metabolic Disorder syndromes that is caused by the h and E factor interaction.Long-term diabetes can cause the chronic complicating diseases of a plurality of systems organ, cause dysfunction and depletion, become disable, lethal main cause.At present, the prevalence of diabetes had the trend of remarkable rising in recent years in the population of China.Because the cause of disease and the pathogenesis of diabetes are not clear fully as yet, therefore also lack effective etiological treatment method at present.Clinically treatment of diabetes is adopted insulinize and oral hypoglycemic drug therapy more now, yet diabetes spp is in a kind of lifelong participation disease, need long-term prescription, the drug administration by injection method of insulin tends to bring many inconvenience to the patient, and clinical orally-taken blood sugar reducing medicine commonly used belongs to chemical drugs more, takes for a long time also and can cause a series of untoward reaction.In view of there being above problem, so exploitation a kind of blood sugar lowering Chinese medicine and health food safe, effective, that be suitable for taking for a long time are badly in need of on present market very much.
Summary of the invention
The object of the invention just provides a kind of Chinese medicine composition with function of blood sugar reduction.
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Fructus Momordicae charantiae 5-30 part, Rhizoma Dioscoreae 5-30 part, tea polyphenols 0.1-1.5 part.
Be preferably:
Fructus Momordicae charantiae 5-15 part, Rhizoma Dioscoreae 15-30 part, tea polyphenols 0.3-0.8 part.
The best is:
10 parts in Fructus Momordicae charantiae, 20 parts of Rhizoma Dioscoreaes, 0.5 part of tea polyphenols.
The preparation method of Chinese medicine composition of the present invention is as follows:
With the Fructus Momordicae charantiae of described weight proportion with Rhizoma Dioscoreae adds water or ethanol extracts, extracting solution is concentrated, dry, make dry extract, be ground into powder, add tea polyphenols, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
The preferred for preparation method of Chinese medicine composition of the present invention is as follows:
Twice of the ethanol extraction that the Fructus Momordicae charantiae of described weight proportion and Rhizoma Dioscoreae is added 10 times of amounts and 8 times of amounts 70%, filter, merging filtrate, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure, make dry extract, be ground into powder, add tea polyphenols, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
Each drug mechanism is as follows among the present invention:
Fructus Momordicae charantiae: having clears away heart-fire makes eye bright, the effect of QI invigorating antipyretic, and Fructus Momordicae charantiae contains Charantin, Charantin etc., and pharmacological evaluation proves that Fructus Momordicae charantiae has the effect of tangible blood sugar lowering.
Rhizoma Dioscoreae: have yin nourishing, moisturize, relieving restlessness, effect such as quench the thirst, pharmacological research shows that Rhizoma Dioscoreae has blood fat reducing and blood glucose effect, and the hyperglycemia that epinephrine is caused has remarkable inhibitory action.
Tea polyphenols: be the general name of polyphenols in the Folium Camelliae sinensis, tangible removing free radical and hypoglycemic effect are arranged.
In the present composition, Fructus Momordicae charantiae is less edible in people's diet as the plant of bitterness is arranged, and has wherein contained the trace element of a large amount of diabetes patient's needs; Rhizoma Dioscoreae: have the effect of nourishing YIN to relieve dryness, and the tonic effect is arranged, solved the common weakly problem of diabetes patient, tea polyphenols is strong free radical scavenger, has the hypoglycemic effect of antiinflammatory; Three medicines are harmonious and fundamentally regulate diabetes patient's body comprehensively, improve diabetes patient's physical condition, and three flavor medicines all have very clear and definite blood sugar lowering pharmacology effect, can be with diabetes patient's blood glucose regulation to normal level.
In sum, the present composition have clear away heart-fire make eye bright, relieving restlessness is quenched the thirst, hypoglycemic effect.Can be used for treating diabetes.Can be used for preparing the Chinese medicine and the health product of prevention and treatment diabetes.
Wood invention with respect to prior art have determined curative effect, have no side effect, taking convenience, cheap advantage.
Further set forth the beneficial effect of Chinese medicine composition of the present invention by following experiment.
For showing the hypoglycemic effect of the present invention, entrust the specified health food functional check of Ministry of Public Health mechanism the present invention to be carried out the animal experiment of blood sugar regulation to diabetes.Table 1 is the influence of the present invention to alloxan induced hyperglycemia rat blood sugar, and table 2 is the influence of the present invention to normal rat blood sugar for the influence of the present invention to alloxan induced hyperglycemia rat post-prandial glycemia, table 3.
Table 1 the present invention is to the influence of alloxan induced hyperglycemia rat blood sugar
| Group | Dosage | Animal | Blood glucose value mmol/L |
| g/kg.BW | (only) | Before being tried | Tried 13 days | Tried 19 days | |
| Normal group | -- | 10 | 3.54±0.85 | 5.93±0.62 | 6.31±0.39 |
| Model group | -- | 10 | 22.13±6.09 | 32.85±4.26 | 35.89±1.93 |
| Low dose group | 1.5 | 10 | 21.91±5.02 | 32.54±3.10 | 33.53±1.95 |
| Middle dosage group | 3.0 | 10 | 21.88±4.75 | 32.33±2.61 | 33.02±1.84 |
| High dose group | 9.0 | 10 | 21.71±5.10 | 32.33±3.87 | 31.79±3.22* |
* compare p＜0.05 with the hyperglycemia model group
Table 2 the present invention is to the influence of alloxan induced hyperglycemia rat post-prandial glycemia
* p＜0.01 of comparing with the hyperglycemia model group
Table 3 the present invention is to the influence of normal rat blood sugar (X ± SD)
Test initial stage F=0.011, P=0.998; Test F=2.102 in latter stage, P=0.118
Table 1-3 result shows that the present invention does not have influence to normal rat blood sugar.High dose of the present invention has tangible reduction effect to the hyperglycemic rat blood glucose due to the alloxan, and middle and high dosage can improve the carbohydrate tolerance by the caused hyperglycemic rat of alloxan.
The specific embodiment
Embodiment 1:
The preparation of the capsule of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 10kg, Rhizoma Dioscoreae 20kg and tea polyphenols 0.5kg, standby;
B) with Fructus Momordicae charantiae and the Rhizoma Dioscoreae ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, filter, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is broken into powder, adds tea polyphenols, drying and adjuvant mix, and are prepared into hard capsule.
Embodiment 2:
The preparation of the granule of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 5kg, Rhizoma Dioscoreae 5kg and tea polyphenols 0.1kg, standby;
B) with Fructus Momordicae charantiae and the Rhizoma Dioscoreae ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added tea polyphenols, add ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 3:
The preparation of the granule of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 30kg, Rhizoma Dioscoreae 30kg and tea polyphenols 1.5kg, standby;
B) with Fructus Momordicae charantiae and the Rhizoma Dioscoreae ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added tea polyphenols, add ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 4:
The preparation of the tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 20kg, Rhizoma Dioscoreae 20kg and tea polyphenols 0.6kg, standby;
B) with Fructus Momordicae charantiae and the Rhizoma Dioscoreae ethanol extraction twice with 10 times of amounts and 8 times of amounts 80%, merge filtrate twice, reclaim ethanol and also be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added tea polyphenols, add adjuvant and make granule, and dry, and compacting is in flakes.
Embodiment 5:
The preparation of the tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 20kg, Rhizoma Dioscoreae 20kg and tea polyphenols 0.6kg, standby;
B) with Fructus Momordicae charantiae and the Rhizoma Dioscoreae ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol and also be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added tea polyphenols, add adjuvant and make granule, and dry, and compacting is in flakes.
Embodiment 6:
The preparation of the effervescent tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 30kg, Rhizoma Dioscoreae 10kg and tea polyphenols 0.3kg, standby;
B) with Fructus Momordicae charantiae and the Rhizoma Dioscoreae ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol and also be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added tea polyphenols, add tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, granulate with dehydrated alcohol, drying adds the lubricant mixing, tabletting, promptly.
Embodiment 7:
The preparation of the dispersible tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 15kg, Rhizoma Dioscoreae 20kg and tea polyphenols 0.8kg, standby;
B) with Fructus Momordicae charantiae and the Rhizoma Dioscoreae ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol and also be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added tea polyphenols, add disintegrating agent, filler or diluent, mix homogeneously adds binding agent and makes soft material, the system granule, and drying adds part disintegrating agent, fluidizer or lubricant mixing, tabletting, promptly.
Claims (6)
1, a kind of Chinese medicine composition with hypoglycemic activity is characterized in that, it is to be made by following bulk drugs: Fructus Momordicae charantiae 5-30 part, Rhizoma Dioscoreae 5-30 part, tea polyphenols 0.1-1.5 part.
According to the Chinese medicine composition of claim 1, it is characterized in that 2, it is to be made by following bulk drugs: Fructus Momordicae charantiae 5-15 part, Rhizoma Dioscoreae 15-30 part, tea polyphenols 0.3-0.8 part.
According to the Chinese medicine composition of claim 1, it is characterized in that 3, it is to be made by following bulk drugs: 10 parts in Fructus Momordicae charantiae, 20 parts of Rhizoma Dioscoreaes, tea polyphenols 0.5g.
4, the preparation method of claim 1 or 2 or 3 described Chinese medicine compositions is characterized in that, this method is:
With the Fructus Momordicae charantiae of described weight proportion with Rhizoma Dioscoreae adds water or ethanol extracts, extracting solution is concentrated, drying makes dry extract, is ground into powder, adds tea polyphenols, is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
5, the preparation method of Chinese medicine composition according to claim 4 is characterized in that, it comprises the following steps:
The Fructus Momordicae charantiae of described weight proportion and Rhizoma Dioscoreae are added the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70%, filter, merging filtrate reclaims ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract, be ground into powder, add tea polyphenols, be prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
6, claim 1 or 2 or 3 described Chinese medicine compositions are used to prepare prevention and the medicine of treatment diabetes disease or the application of health food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101785080A CN101450162A (en) | 2007-11-30 | 2007-11-30 | Traditional Chinese medicine composition with blood-sugar reduction function and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101785080A CN101450162A (en) | 2007-11-30 | 2007-11-30 | Traditional Chinese medicine composition with blood-sugar reduction function and preparation method thereof |
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| CN101450162A true CN101450162A (en) | 2009-06-10 |
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| CNA2007101785080A Pending CN101450162A (en) | 2007-11-30 | 2007-11-30 | Traditional Chinese medicine composition with blood-sugar reduction function and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813195A (en) * | 2012-08-06 | 2012-12-12 | 广水市东晨农业科技有限公司 | Blood glucose-lowering food containing okra and preparation method thereof |
| CN103027327A (en) * | 2012-12-18 | 2013-04-10 | 淮阴工学院 | Nutritional and healthcare yam beverage and preparation method |
| CN108371690A (en) * | 2018-03-29 | 2018-08-07 | 李宏江 | Eight kinds are adjusted liquid hypoglycemic food medicine to combine pill |
-
2007
- 2007-11-30 CN CNA2007101785080A patent/CN101450162A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813195A (en) * | 2012-08-06 | 2012-12-12 | 广水市东晨农业科技有限公司 | Blood glucose-lowering food containing okra and preparation method thereof |
| CN103027327A (en) * | 2012-12-18 | 2013-04-10 | 淮阴工学院 | Nutritional and healthcare yam beverage and preparation method |
| CN108371690A (en) * | 2018-03-29 | 2018-08-07 | 李宏江 | Eight kinds are adjusted liquid hypoglycemic food medicine to combine pill |
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Open date: 20090610 |