CN102068621B - Chinese medicinal composition for treating infantile cold and fever and preparation method thereof - Google Patents
Chinese medicinal composition for treating infantile cold and fever and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating infantile cold and fever and a preparation method thereof, and belongs to the field of the modernization of a traditional Chinese medicine. The Chinese medicinal composition for treating the infantile cold and fever is prepared from the following raw materials in part by weight: 80 parts of scorpion, 70 parts of bile arisaema root, 70 parts of divaricate saposhnikovia root, 70 parts of incised notopterygium rhizome, 60 parts of tall gastrodia tuber, 50 parts of ephedra, 50 parts of gambir plant, 50 parts of mentha haplocalyx, 50 parts of Chinese honeylocust abnormal fruit, 50 parts of biotite schist and mica (calcined), 40 parts of shiraia, 40 parts of tangerine peel, 40 parts of Indian buead, 40 parts of liquoric root, 40 parts of amber, 20 parts of stiff silkworm (stir-fried), 5 parts of centipede, 40 parts of pearl, 10 parts of cinnabar, 10 parts of bezoar, 10 parts of musk and 5 parts of borneol. The invention has the advantages that: compared with the conventional commercially-available formulations, the Chinese medicinal composition has stable and controllable quality, improves the curative effect obviously, reduces the administration dose of patients, improves bioavailability, and has obvious economic and social benefits.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and method for preparing of treating the infantile common cold fever, belong to modern Chinese traditional medicine field.
Background technology
The anxious chronic infantile convulsion of children's is commonly called as convulsion, and more common urgent symptom when being children's is by due to the temporary transient disorder of cerebral cortex function.Age, more little incidence rate was high more, and infant more more to be seen.The traditional Chinese medical science is included the anxious chronic infantile convulsion of children's in " infantile convulsion " category.The traditional Chinese medical science is divided into two types of acute infantile convulsion and chronic infantile convulsions to infantile convulsion.The outbreak of acute infantile convulsion, with the diseases caused by exogenous pathogenic factor seasonal pathogen, in accumulate expectorant heat and be principal element, be main with pathogenic heat especially wherein.Children's is a pure-yang constituent, and Kidney-Yin not filling after the sense heresy, is prone to from transconversion into heat.Pathogenic heat enemy intrusion or invasion's conscience two on the one hand is dirty, the liver main air, and heart master is frightened, and liver-heat can be given birth to heart-fire and shied, the movable again liver-wind of heart-fire, two dirty friendships are striven, and infantile convulsion is to send out.Simultaneously, pathogenic fire decocts body fluid and becomes expectorant, heart spirit confused by phlegm and obnubilation.
During acute infectious diseases hyperpyrexia such as upper respiratory tract infection, acute tonsillitis, pneumonia and infectious disease are early stage, central excitation property increases, nervous dysfunction and the convulsions that causes, the hyperpyrexia convulsion of meaning.Its incidence rate is very high, and the children's of 5-8% hyperthermia once took place was fainted from fear according to investigations, the childhood period of accounting for 30% of the convulsions reason.
XIAOER JIERE WAN is the Chinese medicine that at present commercially available a kind of effective treatment infantile common cold is had a fever, and it adopts 22 flavor medical materials such as Calculus Bovis, Arisaema Cum Bile, Scorpio, Moschus, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, succinum, Margarita, Bombyx Batryticatus (stir-fry), Rhizoma Et Radix Notopterygii, Borneolum Syntheticum, Cinnabaris to process.
This medicine has removing heat-phlegm, and is relieving convulsion, the effect of endogenous wind stopping.Be used for the infantile common cold fever, accumulation and obstruction of sputum, hyperpyrexia and infantile convulsion, stiffness of the nape and back, brothers twitch, and coma is not waken up, the vomiting cough.
The method for making of XIAOER JIERE WAN is: 22 flavor medical materials of recipe quantity, and Margarita, Cinnabaris pulverize separately become impalpable powder, and Calculus Bovis, Moschus, Borneolum Syntheticum pulverize separately become fine powder; 17 flavors such as Scorpio are ground into fine powder; With powder facing-ups such as above-mentioned Cinnabaris, Calculus Boviss, mixing sieves.Every 100g powder adds refined honey 110～130g and processes big honeyed pills, promptly gets, the heavy 1g of every ball.Drug oral, one time 1 ball, 2 times on the one.
This medicine method for making is simple, evident in efficacy.But former prescription type is a honeyed pill, goes mouldy easily and microbiological contamination, and patient's dose is excessive, and children's's dysphagia, mouthfeel are not good.These factor affecting XIAOER JIERE WAN applying clinically.
Summary of the invention
First technical problem that the present invention will solve provides a kind of Chinese medicine composition of treating the infantile common cold fever.
Another technical problem that the present invention will solve provides manufacturing method for above mentioned medicine.
For realizing above-mentioned purpose, the present invention adopts following technical scheme:
A kind of its active component of Chinese medicine composition of treating the infantile common cold fever is processed by the raw material of following parts by weight: 80 parts of Scorpios; 70 parts of Arisaema Cum Bile; Windproof 70 parts; 70 parts of Rhizoma Et Radix Notopterygiis; 60 parts in Rhizoma Gastrodiae; 50 parts in Herba Ephedrae; 50 parts of Ramulus Uncariae Cum Uncis; 50 parts of Herba Menthaes; 50 parts of Fructus Gleditsiae Abnormalis; 50 parts of Lapis Chloriti (forging); 40 parts of Concretio silicea Bambusae seu schizostachyis; 40 parts of Pericarpium Citri Reticulataes; 40 parts in Poria; 40 parts in Radix Glycyrrhizae; 40 parts of succinums; 20 parts of Bombyx Batryticatus (stir-fry); 5 parts of Scolopendras; 40 parts of Margaritas; 10 parts in Cinnabaris; 10 parts of Calculus Boviss; 10 parts in Moschus; 5 parts of Borneolum Syntheticums.
Said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are extracted 2-3 time with 8-14 times of water gaging; Each 1-3 hour; Merge extractive liquid; Be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets.
Said Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are extracted 2-3 time with 10-12 times of water gaging; Each 2-3 hour; Merge extractive liquid; Be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets.
Said Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are extracted 2 times with 10 times of water gagings; Each 2 hours; Merge extractive liquid; Be concentrated into that relative density is 1.06-1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets.
Said pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
Said pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
The dosage form of said Chinese medicine composition is pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of method for preparing of treating the Chinese medicine composition of infantile common cold fever takes by weighing 80 parts of Scorpios, 70 parts of Arisaema Cum Bile, windproof 70 parts, 70 parts of Rhizoma Et Radix Notopterygiis, 60 parts in Rhizoma Gastrodiae, 50 parts in Herba Ephedrae, 50 parts of Ramulus Uncariae Cum Uncis, 50 parts of Herba Menthaes, 50 parts of Fructus Gleditsiae Abnormalis, 50 parts of Lapis Chloriti (forging), 40 parts of Concretio silicea Bambusae seu schizostachyis, 40 parts of Pericarpium Citri Reticulataes, 40 parts in Poria, 40 parts in Radix Glycyrrhizae, 40 parts of succinums, 20 parts of Bombyx Batryticatus (stir-fry), 5 parts of Scolopendras, 40 parts of Margaritas, 10 parts in Cinnabaris, 10 parts of Calculus Boviss, 10 parts in Moschus, 5 parts of Borneolum Syntheticums; Take by weighing each raw material by proportioning raw materials; Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are extracted 2-3 time with 8-14 times of water gaging; Each 1-3 hour; Merge extractive liquid; Be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets.
Said Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are extracted 2-3 time with 10-12 times of water gaging; Each 2-3 hour; Merge extractive liquid; Be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets.
Said Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are extracted 2 times with 10 times of water gagings; Each 2 hours; Merge extractive liquid; Be concentrated into that relative density is 1.06-1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets.
Chinese medicine composition that technical scheme of the present invention is related and preparation thereof all have good removing heat-phlegm, and be relieving convulsion, and safety is taken in the endogenous wind stopping effect.Can be used for infantile common cold fever, accumulation and obstruction of sputum, hyperpyrexia and infantile convulsion, stiffness of the nape and back, brothers twitch, and coma is not waken up, the vomiting cough.Through zoopery, we find that unexpectedly the pharmaceutical composition of prepared of the present invention compared with prior art has excellent refrigeration function.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property and the Pharmacological action study result of each flavour of a drug ingredient, research has obtained the method for preparing of reasonable, stable active component.Adopt technical scheme of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, bioavailability improves, have remarkable economical and social benefit.
Below specify technical scheme of the present invention through embodiment, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription:
Scorpio 80g, Arisaema Cum Bile 70g, windproof 70g, Rhizoma Et Radix Notopterygii 70g, Rhizoma Gastrodiae 60g, Herba Ephedrae 50g, Ramulus Uncariae Cum Uncis 50g, Herba Menthae 50g, Fructus Gleditsiae Abnormalis 50g, Lapis Chloriti (forging) 50g, Concretio silicea Bambusae seu schizostachyi 40g, Pericarpium Citri Reticulatae 40g, Poria 40g, Radix Glycyrrhizae 40g, succinum 40g, Bombyx Batryticatus (stir-fry) 20g, Scolopendra 5g, Margarita 40g, Cinnabaris 10g, Calculus Bovis 10g, Moschus 10g, Borneolum Syntheticum 5g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are with water extraction 2 times; Extract with 14 times of water gagings for the first time, extract each 2 hours for the second time with 10 times of water gagings; Merge extractive liquid; Be concentrated into that relative density is 1.03 under the 50-60 ℃ of condition, drying under reduced pressure obtains dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets active constituents of medicine of the present invention.
Embodiment 2: the preparation Chinese medicine extract
One. prescription:
Scorpio 800g, Arisaema Cum Bile 700g, windproof 700g, Rhizoma Et Radix Notopterygii 700g, Rhizoma Gastrodiae 600g, Herba Ephedrae 500g, Ramulus Uncariae Cum Uncis 500g, Herba Menthae 500g, Fructus Gleditsiae Abnormalis 500g, Lapis Chloriti (forging) 500g, Concretio silicea Bambusae seu schizostachyi 400g, Pericarpium Citri Reticulatae 400g, Poria 400g, Radix Glycyrrhizae 400g, succinum 400g, Bombyx Batryticatus (stir-fry) 200g, Scolopendra 50g, Margarita 400g, Cinnabaris 100g, Calculus Bovis 100g, Moschus 100g, Borneolum Syntheticum 50g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are with water extraction 3 times; Extract with 10 times of water gagings for the first time with for the second time, extract each 1.5 hours for the third time with 8 times of water gagings; Merge extractive liquid; Be concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, drying under reduced pressure obtains dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets active constituents of medicine of the present invention.
Embodiment 3: the preparation Chinese medicine extract
One. prescription:
Scorpio 80g, Arisaema Cum Bile 70g, windproof 70g, Rhizoma Et Radix Notopterygii 70g, Rhizoma Gastrodiae 60g, Herba Ephedrae 50g, Ramulus Uncariae Cum Uncis 50g, Herba Menthae 50g, Fructus Gleditsiae Abnormalis 50g, Lapis Chloriti (forging) 50g, Concretio silicea Bambusae seu schizostachyi 40g, Pericarpium Citri Reticulatae 40g, Poria 40g, Radix Glycyrrhizae 40g, succinum 40g, Bombyx Batryticatus (stir-fry) 20g, Scolopendra 5g, Margarita 40g, Cinnabaris 10g, Calculus Bovis 10g, Moschus 10g, Borneolum Syntheticum 5g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are with water extraction 3 times; Extracted 3 hours with 12 times of water gagings for the first time, extracted 2 hours with 10 times of water gagings for the second time, extracted 1 hour with 8 times of water gagings for the third time; Merge extractive liquid; Be concentrated into that relative density is 1.10 under the 50-60 ℃ of condition, drying under reduced pressure obtains dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets active constituents of medicine of the present invention.
Embodiment 4: the preparation Chinese medicine extract
One. prescription:
Scorpio 80g, Arisaema Cum Bile 70g, windproof 70g, Rhizoma Et Radix Notopterygii 70g, Rhizoma Gastrodiae 60g, Herba Ephedrae 50g, Ramulus Uncariae Cum Uncis 50g, Herba Menthae 50g, Fructus Gleditsiae Abnormalis 50g, Lapis Chloriti (forging) 50g, Concretio silicea Bambusae seu schizostachyi 40g, Pericarpium Citri Reticulatae 40g, Poria 40g, Radix Glycyrrhizae 40g, succinum 40g, Bombyx Batryticatus (stir-fry) 20g, Scolopendra 5g, Margarita 40g, Cinnabaris 10g, Calculus Bovis 10g, Moschus 10g, Borneolum Syntheticum 5g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are with water extraction 3 times; Extracted 2.5 hours with 14 times of water gagings for the first time, extracted 2 hours with 12 times of water gagings for the second time, extracted 1.5 hours with 10 times of water gagings for the third time; Merge extractive liquid; Be concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, spray drying obtains dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets active constituents of medicine of the present invention.
Embodiment 5: the preparation Chinese medicine extract
One. prescription:
Scorpio 80g, Arisaema Cum Bile 70g, windproof 70g, Rhizoma Et Radix Notopterygii 70g, Rhizoma Gastrodiae 60g, Herba Ephedrae 50g, Ramulus Uncariae Cum Uncis 50g, Herba Menthae 50g, Fructus Gleditsiae Abnormalis 50g, Lapis Chloriti (forging) 50g, Concretio silicea Bambusae seu schizostachyi 40g, Pericarpium Citri Reticulatae 40g, Poria 40g, Radix Glycyrrhizae 40g, succinum 40g, Bombyx Batryticatus (stir-fry) 20g, Scolopendra 5g, Margarita 40g, Cinnabaris 10g, Calculus Bovis 10g, Moschus 10g, Borneolum Syntheticum 5g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are with water extraction 2 times; Extracted 2.5 hours with 12 times of water gagings for the first time; For the second time with 10 times of water gagings extractions 2 hours, merge extractive liquid, is concentrated into that relative density is 1.06 under the 50-60 ℃ of condition; Drying under reduced pressure obtains dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets active constituents of medicine of the present invention.
Embodiment 6: the preparation Chinese medicine extract
One. prescription:
Scorpio 80g, Arisaema Cum Bile 70g, windproof 70g, Rhizoma Et Radix Notopterygii 70g, Rhizoma Gastrodiae 60g, Herba Ephedrae 50g, Ramulus Uncariae Cum Uncis 50g, Herba Menthae 50g, Fructus Gleditsiae Abnormalis 50g, Lapis Chloriti (forging) 50g, Concretio silicea Bambusae seu schizostachyi 40g, Pericarpium Citri Reticulatae 40g, Poria 40g, Radix Glycyrrhizae 40g, succinum 40g, Bombyx Batryticatus (stir-fry) 20g, Scolopendra 5g, Margarita 40g, Cinnabaris 10g, Calculus Bovis 10g, Moschus 10g, Borneolum Syntheticum 5g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are with water extraction 2 times; Extracted 3 hours with 10 times of water gagings for the first time; For the second time with 8 times of water gagings extractions 2 hours, merge extractive liquid, is concentrated into that relative density is 1.04 under the 50-60 ℃ of condition; Drying under reduced pressure obtains dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets active constituents of medicine of the present invention.
Embodiment 7: the preparation Chinese medicine extract
One. prescription:
Scorpio 80g, Arisaema Cum Bile 70g, windproof 70g, Rhizoma Et Radix Notopterygii 70g, Rhizoma Gastrodiae 60g, Herba Ephedrae 50g, Ramulus Uncariae Cum Uncis 50g, Herba Menthae 50g, Fructus Gleditsiae Abnormalis 50g, Lapis Chloriti (forging) 50g, Concretio silicea Bambusae seu schizostachyi 40g, Pericarpium Citri Reticulatae 40g, Poria 40g, Radix Glycyrrhizae 40g, succinum 40g, Bombyx Batryticatus (stir-fry) 20g, Scolopendra 5g, Margarita 40g, Cinnabaris 10g, Calculus Bovis 10g, Moschus 10g, Borneolum Syntheticum 5g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (stir-fry), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, Lapis Chloriti (forging), Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae are extracted 2 times with 10 times of water gagings; Each 2 hours; Merge extractive liquid; Be concentrated into that relative density is 1.07 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets active constituents of medicine of the present invention.
Embodiment 8: the preparation tablet
The active component 100g that embodiment 1 obtains adds starch 10g, microcrystalline Cellulose 10g, and cross-linked pvp 3g, tabletting gets tablet, and every is 0.40g.
Embodiment 9: the preparation tablet
The active component 1000g that embodiment 2 obtains adds dextrin 100g, microcrystalline Cellulose 200g, and cross-linked pvp 30g, tabletting gets tablet, and every is 0.42g.
Embodiment 10: zoopery one: extract of the present invention is to the influence of rat fever model due to the dry yeast
One. material and method
XIAOER JIERE WAN (lot number: 081156), produce by Tianjin Zhongxin Pharmaceutical Group Co.
Animal: the wistar rat, male, 180-220g is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., credit number: SCXK (capital) 2002-0003.
Aspirin (lot number: 090205), jiangsu wuxi AstraZeneca pharmaceutical Co. Ltd.
Dry yeast (lot number: 081007), Hubei Angel Yeast Co.,Ltd.
The numeric type clinical thermometer: Dalian Omron (China) Co., Ltd. produces.
Before the experiment rat is placed laboratory endoadaptation environment, laboratory temperature is 20～25 ℃, can be free movable, be coated with vaseline to the end of thermometer probe after, insert the about 2～3cm survey of rat internal rectum body temperature, every day 2 times, adapt to 3 days.Fasting is 10 hours before the experiment, can freely drink water.Earlier with the rat labelling, survey body temperature 2 times during experiment, reject the body temperature fluctuation and surpass 0.3 ℃ rat with method.The meansigma methods of getting 2 body temperature is divided into 6 groups as basal body temperature with rat at random, and except that normal group (10 rats), all the other 5 groups all in rat back subcutaneous injection 20% yeast suspension 10ml/kg.Select body temperature rise person more than 0.g ℃ behind the injection yeast 6h, be divided into model group at random, aspirin group (0.2g/kg); Children's separates that heat extraction substrate (active component that embodiment 1 obtains) is low, high dose group (contain the crude drug amount and be respectively 0.5,1.0g/kg), XIAOER JIERE WAN group (containing crude drug amount 0.5g/kg); Every group 10; Below respectively organize equal gastric infusion 1 time, the administration volume is 20ml/kg, and normal group and model control group give the pure water of respective amount.After the administration 1,2,3,4h surveys body temperature respectively 1 time, record body temperature value, experimental data is added up with variance analysis.
Two. result: see table one.
The result shows: model group, aspirin group and each administration group body temperature all obviously rise behind the rat skin lower injection 20% yeast suspension 6h, with normal group significant difference (P＜0.01) are arranged relatively, and the modeling success is described.1-4h after administration, extract is low, high dose group and model group more all have significant difference, explains that extract of the present invention can make the heating rat temperature descend, and shows as behind administration 1h, to begin cooling, the sustainable 4h of antipyretic effect.2h, 3h after administration, extract low dose group and XIAOER JIERE WAN group comparison refrigeration function have the trend that is superior to the latter; 4h after administration, extract low dose group and XIAOER JIERE WAN group relatively have significant difference (P＜0.05), explain that its refrigeration function of the present invention is superior to former dosage form.
Table one: children's separate heat extraction substrate to the influence of heating rat temperature due to the yeast (℃, n=10, x ± s)
With blank control group than ☆ P＜0.05 ☆ ☆ P＜0.01; With model group than * P＜0.05 * * P＜0.01;
With the XIAOER JIERE WAN group than #P＜0.05 ##P＜0.01
Embodiment 11: zoopery two: extract of the present invention causes the influence of mice convulsion to pentetrazole
One. material and method:
Animal: the ICR mice, 18-22g is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., credit number: SCXK (capital) 2002-0003.
Sodium phenobarbital (lot number 090125) Shanghai Xinya Pharmaceutical Industry Co. Ltd.
4 penta nitrogen (lot number 268011), s i gma company
Get 100 of healthy mices, be divided into 5 groups at random, 20 every group; Be model group, phenobarbital is received group (0.05g/kg), and extract (active component that embodiment 2 obtains) is low, high dose group (contains the crude drug amount and is respectively 0.5; 1.0g/kg), XIAOER JIERE WAN group (containing crude drug amount 0.5g/kg).Each group is irritated the long-pending 10ml/kg that is of body of stomach, and except that model group was given pure water, other each groups were all irritated stomach and given corresponding medicine; Successive administration 5 days, behind the last administration 1h, every mouse peritoneal injection pentetrazole 100g/kg; The incubation period and the mortality rate of fainting from fear take place in record mice convulsion incidence rate.Experimental data is through statistics.
Two. result: see table two.
Table two: children's separates heat extraction substrate causes mice convulsion to pentetrazole influence (x ± s)
With model group than * P＜0.05 * * P＜0.01
The result shows that extract is low, high dose group compares the incubation period and the model group of mice against seizure, and significant difference is all arranged, and explains that extract of the present invention can prolong the incubation period that convulsions takes place, and can reduce mortality rate.Extract low dose group and XIAOER JIERE WAN group be there was no significant difference relatively, explains that its anticonvulsant action is suitable with former dosage form.
Claims (9)
1. Chinese medicine composition of treating infantile common cold fever, it is characterized in that: its active component is processed by the raw material of following parts by weight: 80 parts of Scorpios, 70 parts of Arisaema Cum Bile, windproof 70 parts, 70 parts of Rhizoma Et Radix Notopterygiis, 60 parts in Rhizoma Gastrodiae, 50 parts in Herba Ephedrae, 50 parts of Ramulus Uncariae Cum Uncis, 50 parts of Herba Menthaes, 50 parts of Fructus Gleditsiae Abnormalis, forge 50 parts of Lapis Chloriti, 40 parts of Concretio silicea Bambusae seu schizostachyis, 40 parts of Pericarpium Citri Reticulataes, 40 parts in Poria, 40 parts in Radix Glycyrrhizae, 40 parts of succinums, 20 parts of Bombyx Batryticatus (parched)s, 5 parts of Scolopendras, 40 parts of Margaritas, 10 parts in Cinnabaris, 10 parts of Calculus Boviss, 10 parts in Moschus, 5 parts of Borneolum Syntheticums;
Said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (parched), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, forge Lapis Chloriti, Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae and extract 2-3 time with 8-14 times of water gaging; Each 1-3 hour; Merge extractive liquid; Be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets.
2. a kind of Chinese medicine composition of treating infantile common cold fever according to claim 1 is characterized in that: said Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (parched), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, forge Lapis Chloriti, Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae and extract 2-3 time with 10-12 times of water gaging; Each 2-3 hour; Merge extractive liquid; Be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets.
3. a kind of Chinese medicine composition of treating infantile common cold fever according to claim 2 is characterized in that: said Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (parched), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, forge Lapis Chloriti, Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae and extract 2 times with 10 times of water gagings; Each 2 hours; Merge extractive liquid; Be concentrated into that relative density is 1.06-1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets.
4. according to any one described a kind of Chinese medicine composition of treating the infantile common cold fever in the claim 1 to 3, it is characterized in that: said pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
5. a kind of Chinese medicine composition of treating the infantile common cold fever according to claim 4, it is characterized in that: said pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
6. a kind of Chinese medicine composition of treating the infantile common cold fever according to claim 4, it is characterized in that: the dosage form of said Chinese medicine composition is pill, tablet, capsule or oral liquid.
7. the described a kind of method for preparing of treating the Chinese medicine composition of infantile common cold fever of claim 1 is characterized in that: take by weighing 80 parts of Scorpios, 70 parts of Arisaema Cum Bile, windproof 70 parts, 70 parts of Rhizoma Et Radix Notopterygiis, 60 parts in Rhizoma Gastrodiae, 50 parts in Herba Ephedrae, 50 parts of Ramulus Uncariae Cum Uncis, 50 parts of Herba Menthaes, 50 parts of Fructus Gleditsiae Abnormalis, forge 50 parts of Lapis Chloriti, 40 parts of Concretio silicea Bambusae seu schizostachyis, 40 parts of Pericarpium Citri Reticulataes, 40 parts in Poria, 40 parts in Radix Glycyrrhizae, 40 parts of succinums, 20 parts of Bombyx Batryticatus (parched)s, 5 parts of Scolopendras, 40 parts of Margaritas, 10 parts in Cinnabaris, 10 parts of Calculus Boviss, 10 parts in Moschus, 5 parts of Borneolum Syntheticums; Take by weighing each raw material by proportioning raw materials; Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (parched), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, forge Lapis Chloriti, Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae and extract 2-3 time with 8-14 times of water gaging; Each 1-3 hour; Merge extractive liquid; Be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets.
8. a kind of method for preparing of treating the Chinese medicine composition of infantile common cold fever according to claim 7; It is characterized in that: said Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (parched), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, forge Lapis Chloriti, Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae and extract 2-3 time with 10-12 times of water gaging; Each 2-3 hour; Merge extractive liquid; Be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets.
9. a kind of method for preparing of treating the Chinese medicine composition of infantile common cold fever according to claim 8; It is characterized in that: said Margarita, Cinnabaris, Calculus Bovis, Moschus, Borneolum Syntheticum, Rhizoma Gastrodiae, Scorpio, Bombyx Batryticatus (parched), succinum and Scolopendra pulverize separately, mix fine powder A; Arisaema Cum Bile, windproof, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Pericarpium Citri Reticulatae, Fructus Gleditsiae Abnormalis, Herba Ephedrae, Herba Menthae, forge Lapis Chloriti, Concretio silicea Bambusae seu schizostachyi, Poria and Radix Glycyrrhizae and extract 2 times with 10 times of water gagings; Each 2 hours; Merge extractive liquid; Be concentrated into that relative density is 1.06-1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying obtain dry thing I; Fine powder A and dry thing I are merged, and mixing promptly gets.
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| 中华人民共和国卫生部药典委员会编.小儿解热丸.《中华人民共和国卫生部药品标准中药成方制剂第二十册》.1998,第26页. * |
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