CN102335386B - Chinese medicinal composition for dispersing qi depression, promoting appetite, removing stagnation and stopping pain and preparation method thereof - Google Patents
Chinese medicinal composition for dispersing qi depression, promoting appetite, removing stagnation and stopping pain and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for dispersing qi depression, promoting appetite, removing stagnation and stopping pain and a preparation method thereof, and belongs to the field of traditional Chinese medicine modernization. The active ingredients of the Chinese medicinal composition for dispersing qi depression, promoting appetite, removing stagnation and stopping pain are prepared from the following raw materials in part by weight: 120 parts of costus root, 100 parts of agilawood, 100 parts of tangerine peel, 100 parts of officinal magnolia bark (processed with ginger), 80 parts of cardamom, 80 parts of fructus amomi, 70 parts of fruit of trifoliate orange (fried with bran), 40 parts of green tangerine peel (processed with rice vinegar), 40 parts of cyperus rotundus (processed with rice vinegar), 40 parts of corydalis tuber (processed with rice vinegar), 40 parts of root of Chinese thorowax, 30 parts of curcuma and 30 parts of liquoric root. The composition has the advantages of stable and controllable quality, obviously improved treatment effect compared with that of the conventional market-available formula, reduced dosage taken by a patient, improved bioavailability and obvious economic and social benefit.
Description
Technical field
The present invention relates to Chinese medicine composition and the preparation method of a kind of appetizing of having a respite, the strongly fragrant pain relieving of change, belong to modern Chinese traditional medicine field.
Background technology
Lignum Aquilariae Resinatum Shu Yu ball is the Chinese medicine of at present commercially available a kind of strongly fragrant pain relieving of appetizingization of having a respite, and it is made by the Radix Aucklandiae, Lignum Aquilariae Resinatum, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), Fructus Amomi Rotundus, Fructus Amomi, Fructus Aurantii (parched with bran), Pericarpium Citri Reticulatae Viride (vinegar system), Rhizoma Cyperi (vinegar system), Rhizoma Corydalis (vinegar system), Radix Bupleuri, Rhizoma Curcumae Longae, Radix Glycyrrhizae.Strongly fragrant, pain relieving can be had a respite, be whetted the appetite, change to Lignum Aquilariae Resinatum Shu Yu ball.Be used for distension and fullness of the chest and abdomen, stomach pain, acid regurgitation, dyspepsia, inappetence, gloomy easypro.
Rhizoma Cyperi soothing liver-QI for relieving depression in the side, regulating QI to relieve pain, the circulation of qi promoting of Cortex Magnoliae Officinalis row dampness, alleviating distention in middle-JIAO closes with the soothing liver-QI stomach function regulating except full, and the therapeutic method to keep the adverse QI flowing downwards is except full. be monarch drug.Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Aurantii regulating qi-flowing for harmonizing stomach, pain relieving in accent, Radix Bupleuri, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride dispersing the stagnated live-QI to relieve the stagnation of QI, stopping nausea and vomiting by lowering the adverse flow of QI is ministerial drug altogether.Rhizoma Corydalis, Rhizoma Curcumae Longae blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, Fructus Amomi Rotundus, Fructus Amomi removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting is adjuvant drug.The Radix Glycyrrhizae mediation property of medicine is for making medicine.Full side's compatibility is received the merit of the appetizing of having a respite, the strongly fragrant pain relieving of change altogether.Clinical in being used for distension and fullness of the chest and abdomen, stomach pain, acid regurgitation, dyspepsia, inappetence does not gloomyly relax.
In current high-tech, fast pace, society with keen competition, although material life is very abundant, psychentonia, anxiety ubiquity.These Nervous and Mental Factors are usually the reasons of morbidity.Except speech therapy, Chinese traditional treatment feelings will is hindered the disease that causes a lot of methods, and the most frequently used is the soothing liver-QI for relieving depression method.
Theory of Chinese medical science thinks, long-term psychentonia, pessimal stimulation, depressed uneasiness all can cause depression of liver-QI.Stagnation of liver-QI is not dredged, and various symptoms can appear in functional activity of QI being not smooth, and often follows the abnormal of the mental status.Treating different diseases with the same therapeutic principle, in medical soothing liver-QI for relieving depression method can treat multiple various disease.
Prescription and the method for making of Lignum Aquilariae Resinatum Shu Yu ball are: Radix Aucklandiae 120g, Lignum Aquilariae Resinatum 100g, Pericarpium Citri Reticulatae 100g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 100g, Fructus Amomi Rotundus 80g, Fructus Amomi 80g, Fructus Aurantii (parched with bran) 70g, Pericarpium Citri Reticulatae Viride (vinegar system) 40g, Rhizoma Cyperi (vinegar system) 40g, Rhizoma Corydalis (vinegar system) 40g, Radix Bupleuri 40g, Rhizoma Curcumae Longae 30g, Radix Glycyrrhizae 30g.With 13 flavor medical materials, be ground into fine powder, sieve, mixing.Every 100g powder adds refined honey 170～190g and makes big honeyed pills, and get final product.
This medicine method for making is simple, evident in efficacy.But former prescription type is honeyed pill, easily goes mouldy and microbiological contamination.Take and carry inconvenience, mouthfeel is not good, and every ball weighs 6 grams, and every dose of dose is excessive, and children's, old man and pharyngolaryngitis patient dysphagia are taken inconvenience, and patient's acceptance level is poor.And from oral slow to the gastrointestinal absorption process.These factors directly affect the application clinically of Lignum Aquilariae Resinatum Shu Yu ball, and these factors have affected this medicine applying clinically.
Summary of the invention
First technical problem that the present invention will solve is to provide a kind of appetizing of having a respite, changes the Chinese medicine composition of strongly fragrant pain relieving.
Another technical problem that the present invention will solve is to provide the preparation method of said medicine.
For achieving the above object, the present invention is by the following technical solutions:
The Chinese medicine composition of a kind of appetizing of having a respite, the strongly fragrant pain relieving of change, its active component is made by the raw material of following parts by weight: 120 parts of the Radix Aucklandiae, 100 parts of Lignum Aquilariae Resinatum, 100 parts of Pericarpium Citri Reticulataes, 100 parts of Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), 80 parts, Fructus Amomi Rotundus, 80 parts of Fructus Amomis, 70 parts of Fructus Aurantiis (parched with bran), 40 parts, Pericarpium Citri Reticulatae Viride (vinegar system), 40 parts of Rhizoma Cyperis (vinegar system), 40 parts of Rhizoma Corydalis (vinegar system), 40 parts of Radix Bupleuri, 30 parts, Rhizoma Curcumae Longae, 30 parts, Radix Glycyrrhizae.
Described active component adopts following method to prepare: take each raw material by proportioning raw materials: Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; All the other flavour of a drug water extractions, concentrated, drying obtains dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.Dry thing II is the active component of medicine of the present invention.
Described active component adopts following method to prepare: take each raw material by proportioning raw materials; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; All the other flavour of a drug water extractions, water extraction 2-3 time was extracted 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.03-1.10, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II, dry thing II is active component of the present invention.
Described active component adopts following method to prepare: take each raw material by proportioning raw materials; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; All the other flavour of a drug water extractions, water extraction 2-3 time was extracted 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05-1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II, dry thing II is active component of the present invention.
Described active component adopts following method to prepare: take each raw material by proportioning raw materials; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; All the other flavour of a drug water extractions, water extraction 2 times was extracted 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05-1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II, dry thing II is active component of the present invention.
Described pharmaceutical composition also contains the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
The dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
The preparation method of the Chinese medicine composition of a kind of appetizing of having a respite, the strongly fragrant pain relieving of change takes 120 parts of the Radix Aucklandiae, 100 parts of Lignum Aquilariae Resinatum, 100 parts of Pericarpium Citri Reticulataes, 100 parts of Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), 80 parts, Fructus Amomi Rotundus, 80 parts of Fructus Amomis, 70 parts of Fructus Aurantiis (parched with bran), 40 parts, Pericarpium Citri Reticulatae Viride (vinegar system), 40 parts of Rhizoma Cyperis (vinegar system), 40 parts of Rhizoma Corydalis (vinegar system), 40 parts of Radix Bupleuri, 30 parts, Rhizoma Curcumae Longae, 30 parts, Radix Glycyrrhizae; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2-3 time was extracted 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.03-1.10, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.
In described medical material, Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2-3 time was extracted 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05-1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.
In described medical material, Lignum Aquilariae Resinatum is pulverized, and obtains the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05-1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.
The Chinese medicine composition that technical solution of the present invention is related and preparation thereof all have the good appetizing of having a respite, change strongly fragrant analgesic effect.Can be used for treating distension and fullness of the chest and abdomen, stomach pain, acid regurgitation, dyspepsia, inappetence, gloomy easypro.
By zoopery, we unexpectedly find, the pharmaceutical composition of technique preparation of the present invention is compared with former dosage form, has excellent promotion gastrointestinal motility effect.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property of each flavour of a drug ingredient and the result of study of pharmacological action, research has obtained the preparation method of reasonable, stable active component.Adopt technical solution of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, bioavailability improves, have significant economic and social benefit.
Describe by the following examples technical solution of the present invention in detail, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription: Radix Aucklandiae 120g, Lignum Aquilariae Resinatum 100g, Pericarpium Citri Reticulatae 100g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 100g, Fructus Amomi Rotundus 80g, Fructus Amomi 80g, Fructus Aurantii (parched with bran) 70g, Pericarpium Citri Reticulatae Viride (vinegar system) 40g, Rhizoma Cyperi (vinegar system) 40g, Rhizoma Corydalis (vinegar system) 40g, Radix Bupleuri 40g, Rhizoma Curcumae Longae 30g, Radix Glycyrrhizae 30g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 2 hours with 12 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.03, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.Be active component 375 grams of the present invention.
Embodiment 2: the preparation Chinese medicine extract
One. prescription: Radix Aucklandiae 1200g, Lignum Aquilariae Resinatum 1000g, Pericarpium Citri Reticulatae 1000g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 1000g, Fructus Amomi Rotundus 800g, Fructus Amomi 800g, Fructus Aurantii (parched with bran) 700g, Pericarpium Citri Reticulatae Viride (vinegar system) 400g, Rhizoma Cyperi (vinegar system) 400g, Rhizoma Corydalis (vinegar system) 400g, Radix Bupleuri 400g, Rhizoma Curcumae Longae 300g, Radix Glycyrrhizae 300g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 3 times was extracted 2 hours with 12 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.10, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.Be active component 3765 grams of the present invention.
Embodiment 3: the preparation Chinese medicine extract
One. prescription: Radix Aucklandiae 120g, Lignum Aquilariae Resinatum 100g, Pericarpium Citri Reticulatae 100g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 100g, Fructus Amomi Rotundus 80g, Fructus Amomi 80g, Fructus Aurantii (parched with bran) 70g, Pericarpium Citri Reticulatae Viride (vinegar system) 40g, Rhizoma Cyperi (vinegar system) 40g, Rhizoma Corydalis (vinegar system) 40g, Radix Bupleuri 40g, Rhizoma Curcumae Longae 30g, Radix Glycyrrhizae 30g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.Be active component 315 grams of the present invention.
Embodiment 4: the preparation Chinese medicine extract
One. prescription: Radix Aucklandiae 120g, Lignum Aquilariae Resinatum 100g, Pericarpium Citri Reticulatae 100g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 100g, Fructus Amomi Rotundus 80g, Fructus Amomi 80g, Fructus Aurantii (parched with bran) 70g, Pericarpium Citri Reticulatae Viride (vinegar system) 40g, Rhizoma Cyperi (vinegar system) 40g, Rhizoma Corydalis (vinegar system) 40g, Radix Bupleuri 40g, Rhizoma Curcumae Longae 30g, Radix Glycyrrhizae 30g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 3 times was extracted 2 hours with 8 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.07, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.Be active component 285 grams of the present invention.
Embodiment 5: the preparation Chinese medicine extract
One. prescription: Radix Aucklandiae 120g, Lignum Aquilariae Resinatum 100g, Pericarpium Citri Reticulatae 100g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 100g, Fructus Amomi Rotundus 80g, Fructus Amomi 80g, Fructus Aurantii (parched with bran) 70g, Pericarpium Citri Reticulatae Viride (vinegar system) 40g, Rhizoma Cyperi (vinegar system) 40g, Rhizoma Corydalis (vinegar system) 40g, Radix Bupleuri 40g, Rhizoma Curcumae Longae 30g, Radix Glycyrrhizae 30g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 2 hours with 12 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.Be active component 316 grams of the present invention.
Embodiment 6: the preparation Chinese medicine extract
One. prescription: Radix Aucklandiae 120g, Lignum Aquilariae Resinatum 100g, Pericarpium Citri Reticulatae 100g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 100g, Fructus Amomi Rotundus 80g, Fructus Amomi 80g, Fructus Aurantii (parched with bran) 70g, Pericarpium Citri Reticulatae Viride (vinegar system) 40g, Rhizoma Cyperi (vinegar system) 40g, Rhizoma Corydalis (vinegar system) 40g, Radix Bupleuri 40g, Rhizoma Curcumae Longae 30g, Radix Glycyrrhizae 30g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 2 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.06, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.Be active component 290 grams of the present invention.
Embodiment 7: the preparation Chinese medicine extract
One. prescription: Radix Aucklandiae 120g, Lignum Aquilariae Resinatum 100g, Pericarpium Citri Reticulatae 100g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 100g, Fructus Amomi Rotundus 80g, Fructus Amomi 80g, Fructus Aurantii (parched with bran) 70g, Pericarpium Citri Reticulatae Viride (vinegar system) 40g, Rhizoma Cyperi (vinegar system) 40g, Rhizoma Corydalis (vinegar system) 40g, Radix Bupleuri 40g, Rhizoma Curcumae Longae 30g, Radix Glycyrrhizae 30g
Two. method for making:
Take each raw material by proportioning raw materials, standby; Lignum Santali Albi, Lignum Aquilariae Resinatum are pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 1 hour with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.Be active component 309 grams of the present invention.
Embodiment 8: the preparation tablet
The active component 100g that embodiment 1 obtains adds microcrystalline Cellulose 10g, lactose 10g, and cross-linked pvp 5g, tabletting gets tablet, and every is 0.25g.
Embodiment 9: the preparation granule
The active component 500g that embodiment 2 obtains adds dextrin 100g, xylitol 400g, and citric acid 1g, aspartame 1g granulates, and gets granule, and every bag is 5g.
Embodiment 10: zoopery one: the impact of extract of the present invention on the mouse small intestine progradation
One. materials and methods
Lignum Aquilariae Resinatum Shu Yu ball (lot number: 090867), reach core hall pharmaceutical factory by new Pharmaceutical limited company in Tianjin and produce
Animal: the ICR mice is provided credit number by Beijing Vital River Experimental Animals Technology Co., Ltd.: SCXK (capital) 2002-0003.
Cisapride is produced by Xian-Janssen Pharmaceutical Ltd., and carbon powder is produced by northization glass purchase and sale center, Tianjin
Arabic gum is produced by Tianjin pharmaceuticals
Get 60 of healthy ICR mices, body weight 18～22g is divided into 5 groups at random, and namely blank is organized, cisapride positive controls, basic, normal, high group of Lignum Aquilariae Resinatum Shu Yu ball group, Lignum Aquilariae Resinatum Shu Yu extract.dosage is: blank group is filled with purified water, cisapride positive drug group is filled with 10mg/kg cisapride medicinal liquid, Lignum Aquilariae Resinatum Shu Yu ball group is filled with 6g crude drug/kg Lignum Aquilariae Resinatum Shu Yu ball medicinal liquid, Lignum Aquilariae Resinatum Shu Yu extract (embodiment 3 method preparations) is low, in, high group is filled with respectively with 1.5, 3, 6g crude drug/kg Lignum Aquilariae Resinatum Shu Yu extract medicinal liquid, the administration volume is 20ml/kg, gastric infusion is 7 days continuously, before the last administration, fasting is 16 hours, after administration, 60 minutes every mouse stomaches only give 5% carbon powder (10% arabic gum) suspension 0.3ml/, take off cervical vertebra after 15 minutes and put to death animal, cut open the belly immediately, separate mesentery, the clip upper end is to pylorus, the lower end is to ileocecal intestinal pipe, be tiled on glass plate, draw gently linearly, measuring Length of intestine is " small intestinal total length ", distance conduct " carbon powder is at the enteral advance distance " from pylorus to the carbon powder forward position, calculate ink propulsive rate.
Two. result: see Table 1.
The impact that the administration of table 1 extract advanced mouse small intestine in seven days
Compare * P＜0.05 with the blank group, * * P＜0.01
Result shows: Lignum Aquilariae Resinatum Shu Yu extract promotes the function that length specification Lignum Aquilariae Resinatum Shu Yu extract that the small intestinal carbon powder advances has good promotion mouse small intestine to advance 3, under the dosage of 6g crude drug/kg 3, under the dosage of 6g crude drug/kg.
Embodiment 11: zoopery two: the impact that extract of the present invention is emptying on Mouse Stomach
One. method:
Get 60 of healthy ICR mices, body weight 18～22g is divided into 5 groups at random, and namely blank is organized, cisapride positive controls, basic, normal, high group of Lignum Aquilariae Resinatum Shu Yu ball group, Lignum Aquilariae Resinatum Shu Yu extract.Dosage is: blank group is filled with purified water; Cisapride positive drug group is filled with 10mg/kg cisapride medicinal liquid; Lignum Aquilariae Resinatum Shu Yu ball group is filled with 6g crude drug/kg Lignum Aquilariae Resinatum Shu Yu ball medicinal liquid; Basic, normal, high group of Lignum Aquilariae Resinatum Shu Yu extract (embodiment 3 methods preparation) is filled with respectively with 1.5,3,6g crude drug/kg Lignum Aquilariae Resinatum Shu Yu extract medicinal liquid, the administration volume is 20ml/kg, gastric infusion is 7 days continuously, before the last administration, fasting is 16 hours, after administration, 60 minutes every mouse stomaches give the semi-solid paste of trophism (by milk powder, sugar, starch forms) 0.8ml/ only, take off cervical vertebra after 20 minutes and put to death mice.Open abdomen and get stomach, claim stomach full weight and net weight, calculate the gastric residue and account for institute to fill with the percentage by weight of semisolid paste be the gastric residual rate.
Experimental data is added up with variance analysis.
Two. result: see Table 2.
The impact emptying on Mouse Stomach in seven days of table 2 extract successive administration
Compare * P＜0.05, * * P＜0.01 with the blank group
Result shows: result shows: Lignum Aquilariae Resinatum Shu Yu extract reduces residual quantity in Mouse Stomach 3, under the dosage of 6g crude drug/kg, illustrates that Lignum Aquilariae Resinatum Shu Yu extract has the good emptying function of promotion Mouse Stomach 3, under the dosage of 6g crude drug/kg.
Claims (10)
1. Chinese medicine composition of the strongly fragrant pain relieving of appetizingization of having a respite, it is characterized in that: its active component is made by the raw material of following parts by weight: 120 parts of the Radix Aucklandiae, 100 parts of Lignum Aquilariae Resinatum, 100 parts of Pericarpium Citri Reticulataes, 100 parts of Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), 80 parts, Fructus Amomi Rotundus, 80 parts of Fructus Amomis, 70 parts of stir-baked Fructus Aurantii in bran, 40 parts of Pericarpium Citri Reticulatae Viride (processed with vinegar), 40 parts of Rhizoma Cyperi (processed with vinegar), 40 parts of Rhizoma Corydalis (processed with vinegar), 40 parts of Radix Bupleuri, 30 parts, Rhizoma Curcumae Longae, 30 parts, Radix Glycyrrhizae; Take each raw material by proportioning raw materials, Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, concentrated, obtain concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II; Dry thing II is the active component of medicine of the present invention.
2. the Chinese medicine composition of a kind of strongly fragrant pain relieving of appetizingization of having a respite according to claim 1 is characterized in that: describedly take each raw material by proportioning raw materials; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2-3 time was extracted 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.03-1.10, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.
3. the Chinese medicine composition of a kind of strongly fragrant pain relieving of appetizingization of having a respite according to claim 2 is characterized in that: describedly take each raw material by proportioning raw materials; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2-3 time was extracted 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05-1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.
4. the Chinese medicine composition of a kind of strongly fragrant pain relieving of appetizingization of having a respite according to claim 3 is characterized in that: describedly take each raw material by proportioning raw materials; Lignum Aquilariae Resinatum is pulverized, obtain heavy powder; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05-1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II.
5. the Chinese medicine composition of any one described a kind of strongly fragrant pain relieving of appetizingization of having a respite according to claim 1 to 4, it is characterized in that: described pharmaceutical composition also contains the acceptable adjuvant of pharmaceutics.
6. the Chinese medicine composition of a kind of strongly fragrant pain relieving of appetizingization of having a respite according to claim 5, it is characterized in that: the acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
7. the Chinese medicine composition of a kind of strongly fragrant pain relieving of appetizingization of having a respite according to claim 5, it is characterized in that: the dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.
8. the preparation method of the Chinese medicine composition of a kind of appetizing of having a respite claimed in claim 1, the strongly fragrant pain relieving of change is characterized in that: take 120 parts of the Radix Aucklandiae, 100 parts of Lignum Aquilariae Resinatum, 100 parts of Pericarpium Citri Reticulataes, 100 parts of Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), 80 parts, Fructus Amomi Rotundus, 80 parts of Fructus Amomis, 70 parts of stir-baked Fructus Aurantii in bran, 40 parts of Pericarpium Citri Reticulatae Viride (processed with vinegar), 40 parts of Rhizoma Cyperi (processed with vinegar), 40 parts of Rhizoma Corydalis (processed with vinegar), 40 parts of Radix Bupleuri, 30 parts, Rhizoma Curcumae Longae, 30 parts, Radix Glycyrrhizae; Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2-3 time was extracted 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.03-1.10, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II; Dry thing II is the active component of medicine of the present invention.
9. the preparation method of the Chinese medicine composition of a kind of appetizing of having a respite according to claim 8, the strongly fragrant pain relieving of change is characterized in that: Lignum Aquilariae Resinatum is pulverized, obtain the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2-3 time was extracted 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05-1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II; Dry thing II is the active component of medicine of the present invention.
10. the preparation method of the Chinese medicine composition of a kind of appetizing of having a respite claimed in claim 8, the strongly fragrant pain relieving of change is characterized in that: in described medical material, Lignum Aquilariae Resinatum is pulverized, and obtains the Lignum Aquilariae Resinatum powder; With all the other flavour of a drug water extractions, water extraction 2 times was extracted 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that under 50-60 ℃ of condition, relative density is 1.05-1.08, and is concentrated, obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and Lignum Aquilariae Resinatum powder mix homogeneously, obtain dry thing II; Dry thing II is the active component of medicine of the present invention.
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| 中华人民共和国卫生部药典委员会.《》.《卫生部颁药品标准 中药成方制剂第十册》.1995,第75页. * |
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