CN105663227A - Drug combination for preventing and treating infantile cerebral palsy and preparation method thereof - Google Patents
Drug combination for preventing and treating infantile cerebral palsy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a drug combination for preventing and treating infantile cerebral palsy and a preparation method thereof.The drug combination is prepared by proportioning Thyrocarpus sampsonii hance, all grass of Herba centaurii, Pilea pumila, isopimpinellin, Adlumidine and Peonidin which serve as active pharmaceutical ingredients, can be prepared into various dosage forms according to conventional preparation processes and has remarkable prevention and treatment effect on the infantile cerebral palsy.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, particularly relate to a kind of pharmaceutical composition and its preparation method of preventing and treating cerebral palsy of children.
Background technology
Children's's cerebral plasy refers to children's at period from prenatal to postnatal because of brain damage, makes the syndromes that the function of brain spinal nerves out of hand is then lost. Its main clinical manifestation is that central motion obstacle and posture are abnormal, have can with mental retardation, aphasis, epilepsy, look dysacousis etc. Belong to the category of motherland's medical science/impotence card 0. Its morbidity and congenital innate deficiency, deficiency of kidney yang, brains lose supports; The breast food imbalance day after tomorrow, deficiency-weakness of spleen-QI, it is foster relevant that the evil poison of infection waits muscles and bones to lose. Its main pathology shows as pallium atrophy in various degree, and gyrus narrows, and brain ditch is obviously broadening, and the protein under cortex has loose change, even form capsule chamber. Under mirror, show as neurocyte reduced number, and have degeneration. The position of pathology determines the basis of clinical symptom with sign, though have above somatotype neither completely reliably because infant often shows as the symptom of mixed type. The type of pathology is determined according to distinctive symptom. Spasm type, brothers' Xu's ejector half, ataxia type, tetanic type and mixed type five kinds can be divided into, and spasm type is the most common according to its clinical manifestation. The diseased region of spasm type is mainly at pallium and pyramidal tract; The diseased region of brothers' Xu's ejector half is at brain substrate tuberal part; The diseased region of ataxia type is at cerebellum; The pathology impact scope of tetanic type is relatively wide, and with pallium, precentral gyrus place is main; Mixed type exists for common with spasm type and brothers' Xu's ejector half merging.
Early diagnosis, early treatment are the fundamental principles for the treatment of cerebral palsy of children, and composite treatment is the best method for the treatment of brain paralysis. Wherein rehabilitation training is the basic method of CP children sending function. Because rehabilitation training can make brain cell obtain the feedback information of proper motion. And the integrated approachs such as traditional Chinese medicine for oral administration, acupuncture, massage can improve the muscular tension of infant effectively, it is to increase the volume of blood flow of brain cell and muscle tissue, improve the oxygen supply of tissue, accelerate functional compensation or tempo, for rehabilitation training provides necessary physiological foundation. There is no effective medicine for the treatment of cerebral palsy of children at present.
Root of Sampsonii hance: the full grass of Boraginaceae root of Sampsonii hance platymiscium root of Sampsonii hance ThyrocarpussampsoniiHance. Adopt full grass 4～June, dry. [nature and flavor] are bitter; Cool. [return through] heart; Large intestine channel. [function cures mainly] clearing heat, releasing toxin, removing swelling. Main carbuncle swells; Furunculosis; Have sore throat; Have loose bowels; Dysentery. [proterties] stem is relatively thin, and 1 to several, cylindrical, long 10-30cm, surperficial withered green, the rough hair of tool canescence, the crisp frangibility of matter, section white. Basal leaf is grown thickly, and shrinkage is curling, and after moistening expansion, cochlear, tool handle, long 3.5-19cm, wide 1-5cm, withered green or deep green, the equal tool canescence coarse wool in two sides, stem leaf is less, without handle.Blade is slightly thick. Sometimes visible blue or purple little Hua. Or having the pyrene of two layers of bowl-shape projection, base top exterior layer has upright gear, and internal layer is close to edge. The micro-mildly bitter flavor of gas. Record in Chinese medicine voluminous dictionary.
Ai Lei: this product is Gentianaceae hundred golden flower platymiscium hundred golden flower CentauriumpulchellumDrucevar.al-taicum(Griseb.) Kitag.etHara [Erythraearamosissimavar.al-taicaGriseb.; Centauriummeyeri(Bunge) Druce ］ wounded in the battle full grass. Gather when blooming, dry. [nature and flavor] are bitter; Cold in nature. [return through] liver; Stomach warp. [function cures mainly] is clearing heat and detoxicating. Main hepatitis; Cholecystitis; Have a headache and fever; Toothache; Tonsillitis. [former phytomorph] annual herb, high 20～30 centimetres. Stem four prismatic, has branch. Leaf is to life, without handle, lanceolar, long 1.5～2 centimetres, wide 4～6 millimeters. Flower armpit is raw or top is raw, spends more, and calyx 5 splits; Corolla white or lavender, 5 split, and cylindrical fireworks are elongated; Stamen 5, flower pesticide Long Circle, Post flowering is curling in the shape of a spiral. Capsule long column shape, 7～September of florescence. Record in Chinese medicine voluminous dictionary.
Pilea mongolica: this product is Urticaceae Rhizoma Belamcandae platymiscium pilea mongolica Pileapumila (L.) A.Cray ［ Ur-ticapumilaL.; P.mongolicaWedd. ］ full grass or rhizome. Summer, autumn gather, and clean, dry. [nature and flavor] are sweet; Cold in nature. [function cures mainly] heat-clearing; Diuresis; Removing toxic substances. Main urinary tract infections; Acute nephritis; Endometritis; Uterine prolapse; Leucorrhea with red and white discharge; Wound; Carbuncle swollen from the beginning of; Worm snakebite. [original shape state] annual herb, high 40-100cm. Stem is upright, normal branch, light green, without hair, meat, and transparent shape sometimes. Leaf is to life; The long 1-4cm of petiole, relative petiole Length discrepancy; Stipule is little, caducous; Blade water chestnut shape is avette or width egg shape, long 2-10cm, wide 1-7cm, and tip is gradually sharp, base portion width wedge shape, and all there is wire cystolith on two sides, and there is thick sawtooth at edge more than base portion; Base goes out 3, arteries and veins. Flower monoecism, same to sequence, sometimes different strain; Cyme scorpion shape of tail, sometimes in the shape that clusters, male tapel 2, boat-shaped, the nearly tip in the back side has short angle, stamen 2, with perianth to life; Female tapel 3, narrow lanceolar, gynoecium 1. Achene is flat avette, and brown is smooth. The month at florescence 8-10, fruit month phase 9-11. Record in Chinese medicine voluminous dictionary.
Different fennel celery tonka bean camphor (Isopimpinellin): CAS 482-27-9, molecular formula C13H10O5, molecular weight 246.21. [pharmacological action] antitumor (suppressing HeLa cell proliferation). [composition source] smelly grass Rutagraveolens, levisticum Angelicapubescensf.biserrata [Syn.Angelicapubescens], Root of Asiatic Toddalia Toddaliaasiatica [Syn.Toddaliaaculeata], root of langdu Stellerachamaejasme, Fructus Cnidii Cnidiummonnieri, citron leaf Citrusmedica, yungning angelica root Heracle.
Alkali (Adlumidine) determined by mountain edge grass: CAS 550-49-2, molecular formula C20H17NO6, molecular weight 367.36. [pharmacological action] has the effect in excited uterus. [composition source] bloodroot deep shape mountain edge grass AdlumiafungosaGreene, Hotseason grow Corydalisdecumbens (Thunb.) Pers. stem tuber, C. incisa Corydalisincisa (Thunb.) Pers. is entirely careless, short point corydalis CorydalismucroniferaMaxim.
Peonidin (Peonidin): CAS 26838-13-1, molecular formula C22H23ClO11, molecular weight 498.87. [pharmacological action] anti-inflammation. [composition source] Ericaceae bird meal tree belongs to berry, during yak Er Miao section's Pelargonium and tree peony section Chinese herbaceous peony genus are spent.
3 bulk drug structures:
Alkali (Adlumidine) determined by mountain edge grass
Different fennel celery tonka bean camphor (Isopimpinellin) peonidin (Peonidin).
Summary of the invention
It is an object of the invention to overcome the deficiency of background technology, it is provided that the pharmaceutical composition of a kind of effective control cerebral palsy of children and its preparation method.
The present invention adopts following technical scheme to realize:
Composition and the weight part of making the bulk drug of the pharmaceutical composition of this control cerebral palsy of children be:
Alkali 146-148 weight part peonidin 142-144 weight part determined by root of Sampsonii hance 1920-1940 weight part dust flower bud 2900-2920 weight part pilea mongolica 2490-2498 weight part different fennel celery coumarin 1 50-154 weight part mountain edge grass.
Preferred for preventing and treating the pharmaceutical composition of cerebral palsy of children, it is made up of the bulk drug of following weight part:
Alkali 147 weight part peonidin 143 weight part determined by root of Sampsonii hance 1930 weight part dust flower bud 2910 weight part pilea mongolica 2494 weight part different fennel celery coumarin 1 52 weight part mountain edge grass.
A kind of pharmaceutical composition preventing and treating cerebral palsy of children, it is characterised in that pharmaceutical composition can adopt the ordinary method of technology of pharmaceutics be prepared into tablet or capsule or drip ball.
A kind of pharmaceutical composition preventing and treating cerebral palsy of children, it is characterised in that pharmaceutical composition and the control cerebral palsy of children medicine of chemistry medicine or Chinese medicine composition.
The preparation method of a kind of pharmaceutical composition preventing and treating cerebral palsy of children, it is characterised in that prepare as follows:
The composition of bulk drug and weight part be: alkali 146-148 weight part peonidin 142-144 weight part determined by edge grass in root of Sampsonii hance 1920-1940 weight part dust flower bud 2900-2920 weight part pilea mongolica 2490-2498 weight part different fennel celery coumarin 1 50-154 weight part mountain;
Preparation method:
(1) Ai Lei is got by bulk drug proportioning, pilea mongolica, root of Sampsonii hance, different fennel celery tonka bean camphor, alkali determined by mountain edge grass, peonidin, mixed even, with weight percent concentration 28% ethanol as solvent, get 28 DEG C of warm lixiviates, extraction time is 5 times, each extraction time is 18 hours, each solvent load is 19 times of bulk drug gross weight, filter, obtain dregs of a decoction A and extracting solution A, extracting solution A reclaims ethanol, concentrate to relative density 1.18, filter, liquid is by D743 macroporous adsorptive resins, first wash with water, again with weight percent concentration 49% ethanolic soln wash-out D743 macroporous adsorptive resins, collect weight percent concentration 49% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) dregs of a decoction A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 2 times, each extraction time is 1.5 hours, each solvent load is 14 times of dregs of a decoction A weight, filter, obtain dregs of a decoction B and extracting solution B, extracting solution B reclaims ethanol, concentrate to relative density 1.16, filter, liquid is by D807 macroporous adsorptive resins, first wash with water, again with weight percent concentration 67% ethanolic soln wash-out D807 macroporous adsorptive resins, collect weight percent concentration 67% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract B,
(3) extract A and extract B are mixed even, obtain pharmaceutical composition.
The preparation method of preferred a kind of pharmaceutical composition preventing and treating cerebral palsy of children, it is characterised in that prepare as follows:
The composition of bulk drug and weight part be: alkali 147 weight part peonidin 143 weight part determined by edge grass in root of Sampsonii hance 1930 weight part dust flower bud 2910 weight part pilea mongolica 2494 weight part different fennel celery coumarin 1 52 weight part mountain;
Preparation method:
(1) Ai Lei is got by bulk drug proportioning, pilea mongolica, root of Sampsonii hance, different fennel celery tonka bean camphor, alkali determined by mountain edge grass, peonidin, mixed even, with weight percent concentration 28% ethanol as solvent, get 28 DEG C of warm lixiviates, extraction time is 5 times, each extraction time is 18 hours, each solvent load is 19 times of bulk drug gross weight, filter, obtain dregs of a decoction A and extracting solution A, extracting solution A reclaims ethanol, concentrate to relative density 1.18, filter, liquid is by D743 macroporous adsorptive resins, first wash with water, again with weight percent concentration 49% ethanolic soln wash-out D743 macroporous adsorptive resins, collect weight percent concentration 49% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) dregs of a decoction A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 2 times, each extraction time is 1.5 hours, each solvent load is 14 times of dregs of a decoction A weight, filter, obtain dregs of a decoction B and extracting solution B, extracting solution B reclaims ethanol, concentrate to relative density 1.16, filter, liquid is by D807 macroporous adsorptive resins, first wash with water, again with weight percent concentration 67% ethanolic soln wash-out D807 macroporous adsorptive resins, collect weight percent concentration 67% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract B,
(3) extract A and extract B are mixed even, obtain pharmaceutical composition.
The preparation method of a kind of pharmaceutical composition preventing and treating cerebral palsy of children, it is characterised in that pharmaceutical composition can adopt the ordinary method of technology of pharmaceutics be prepared into tablet or capsule or drip ball.
The preparation method of a kind of pharmaceutical composition preventing and treating cerebral palsy of children, it is characterised in that pharmaceutical composition and chemistry medicine or Chinese medicine composition control cerebral palsy of children medicine.
Pharmaceutical composition control cerebral palsy of children is evident in efficacy.
Embodiment
Embodiment 1: the pharmaceutical composition of control cerebral palsy of children and its preparation method
The composition of bulk drug and the weight part of the pharmaceutical composition of control cerebral palsy of children be: alkali 147g peonidin 143g determined by edge grass in root of Sampsonii hance 1930g dust flower bud 2910g pilea mongolica 2494g different fennel celery coumarin 1 52g mountain;
Preparation method:
(1) Ai Lei is got by bulk drug proportioning, pilea mongolica, root of Sampsonii hance, different fennel celery tonka bean camphor, alkali determined by mountain edge grass, peonidin, mixed even, with weight percent concentration 28% ethanol as solvent, get 28 DEG C of warm lixiviates, extraction time is 5 times, each extraction time is 18 hours, each solvent load is 19 times of bulk drug gross weight, filter, obtain dregs of a decoction A and extracting solution A, extracting solution A reclaims ethanol, concentrate to relative density 1.18, filter, liquid is by D743 macroporous adsorptive resins, first wash with water, again with weight percent concentration 49% ethanolic soln wash-out D743 macroporous adsorptive resins, collect weight percent concentration 49% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) dregs of a decoction A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 2 times, each extraction time is 1.5 hours, each solvent load is 14 times of dregs of a decoction A weight, filter, obtain dregs of a decoction B and extracting solution B, extracting solution B reclaims ethanol, concentrate to relative density 1.16, filter, liquid is by D807 macroporous adsorptive resins, first wash with water, again with weight percent concentration 67% ethanolic soln wash-out D807 macroporous adsorptive resins, collect weight percent concentration 67% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract B,
(3) extract A and extract B are mixed even, obtain pharmaceutical composition.
Embodiment 2: the pharmaceutical composition of control cerebral palsy of children and its preparation method
The composition of bulk drug and the weight part of the pharmaceutical composition of control cerebral palsy of children be: alkali 146g peonidin 144g determined by edge grass in root of Sampsonii hance 1920g dust flower bud 2920g pilea mongolica 2490g different fennel celery coumarin 1 54g mountain;
Preparation method:
(1) Ai Lei is got by bulk drug proportioning, pilea mongolica, root of Sampsonii hance, different fennel celery tonka bean camphor, alkali determined by mountain edge grass, peonidin, mixed even, with weight percent concentration 28% ethanol as solvent, get 28 DEG C of warm lixiviates, extraction time is 5 times, each extraction time is 18 hours, each solvent load is 19 times of bulk drug gross weight, filter, obtain dregs of a decoction A and extracting solution A, extracting solution A reclaims ethanol, concentrate to relative density 1.18, filter, liquid is by D743 macroporous adsorptive resins, first wash with water, again with weight percent concentration 49% ethanolic soln wash-out D743 macroporous adsorptive resins, collect weight percent concentration 49% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) dregs of a decoction A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 2 times, each extraction time is 1.5 hours, each solvent load is 14 times of dregs of a decoction A weight, filter, obtain dregs of a decoction B and extracting solution B, extracting solution B reclaims ethanol, concentrate to relative density 1.16, filter, liquid is by D807 macroporous adsorptive resins, first wash with water, again with weight percent concentration 67% ethanolic soln wash-out D807 macroporous adsorptive resins, collect weight percent concentration 67% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract B,
(3) extract A and extract B are mixed even, obtain pharmaceutical composition.
Embodiment 3: the pharmaceutical composition of control cerebral palsy of children and its preparation method
The composition of bulk drug and the weight part of the pharmaceutical composition of control cerebral palsy of children be: alkali 148g peonidin 142g determined by edge grass in root of Sampsonii hance 1940g dust flower bud 2900g pilea mongolica 2498g different fennel celery coumarin 1 50g mountain;
Preparation method:
(1) Ai Lei is got by bulk drug proportioning, pilea mongolica, root of Sampsonii hance, different fennel celery tonka bean camphor, alkali determined by mountain edge grass, peonidin, mixed even, with weight percent concentration 28% ethanol as solvent, get 28 DEG C of warm lixiviates, extraction time is 5 times, each extraction time is 18 hours, each solvent load is 19 times of bulk drug gross weight, filter, obtain dregs of a decoction A and extracting solution A, extracting solution A reclaims ethanol, concentrate to relative density 1.18, filter, liquid is by D743 macroporous adsorptive resins, first wash with water, again with weight percent concentration 49% ethanolic soln wash-out D743 macroporous adsorptive resins, collect weight percent concentration 49% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) dregs of a decoction A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 2 times, each extraction time is 1.5 hours, each solvent load is 14 times of dregs of a decoction A weight, filter, obtain dregs of a decoction B and extracting solution B, extracting solution B reclaims ethanol, concentrate to relative density 1.16, filter, liquid is by D807 macroporous adsorptive resins, first wash with water, again with weight percent concentration 67% ethanolic soln wash-out D807 macroporous adsorptive resins, collect weight percent concentration 67% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract B,
(3) extract A and extract B are mixed even, obtain pharmaceutical composition.
Embodiment 4: the preparation of tablet
Example 1 pharmaceutical composition 309g, adds starch 91g, mixed even, granulates, dry, adds Microcrystalline Cellulose 33g, Magnesium Stearate 2g, mixed even, is pressed into 1000, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Example 2 pharmaceutical composition 309g, adds starch 71g, mixed even, granulates, and dry, whole grain, adds appropriate Magnesium Stearate, mixed even, encapsulated 1000, obtains medicament composition capsule.
Embodiment 6: the preparation dripping ball
Taking polyethylene glycol 6000 199g water-bath (80 DEG C) heating boils molten, add embodiment 3 pharmaceutical composition 21g, stir, it is refrigerant taking whiteruss, put in Glass tubing (4*80cm), cooling temperature is 8 DEG C, dripping external diameter in mouth is 7.0/2.0 (mm/mm), and dripping mouth apart from liquid level is 1.8cm, drips speed often to divide 42 as top condition, blot the condensing agent dripping ball surface with cotton, obtain medicament composition dropping pills.
Embodiment 7: the pharmaceutical composition of control cerebral palsy of children
The composition of bulk drug and the weight part of the pharmaceutical composition of control cerebral palsy of children be:
Alkali 140 weight part peonidin 110 weight part determined by root of Sampsonii hance 2820 weight part different fennel celery coumarin 1 13 weight part mountain edge grass.
Embodiment 8: the pharmaceutical composition of control cerebral palsy of children
The composition of bulk drug and the weight part of the pharmaceutical composition of control cerebral palsy of children be:
Alkali 180 weight part peonidin 160 weight part determined by root of Sampsonii hance 2536 weight part different fennel celery coumarin 1 20 weight part mountain edge grass.
Embodiment 9: the pharmaceutical composition of control cerebral palsy of children
The composition of bulk drug and the weight part of the pharmaceutical composition of control cerebral palsy of children be:
Alkali 130 weight part peonidin 130 weight part determined by root of Sampsonii hance 2478 weight part different fennel celery coumarin 1 50 weight part mountain edge grass.
Experimental example 1: the experimental study of control cerebral palsy of children
1 clinical data
1.1 physical data
20 Li Jun pastern bone section outpatient service infants. The wherein male sex 11 example, women 9 example; Age: 3 months-1 year old person 8 example, 2-4 year person 8 example, 5-7 year person 4 example.
The cause of disease: obstetric forceps institute the wounded 6 example during childbirth, long term hypoxia (application analgesic agent and narcotic, umbilical cord block around fetus neck or tracheae) person 8 example, encephalitis person 2 example, difficult labour childbirth person 4 example.
Somatotype: spasm type 13 example, brothers' Xu's ejector half 3 example, ataxia type 1 example, mixed type 3 example.
Flesh power measures: 2 grades of flesh power person 4 examples, 3 grades of flesh power person 7 examples, 4 grades of flesh power person 8 examples, 5 grades of flesh power person 1 examples.
Intelligence measures: slight low person 13 example, low person 5 example of middle degree, low person 2 example of severe.
1.2 Case definition
With reference to Case definition and the somatotype of high Chinese materia medica universities and colleges teaching material " traditional Chinese medical science osteopathy # cerebral palsy ". (1) spasm type: the most common with tetraplegia, newborn infant can show abnormal posture, lacks normal reactions such as being sucked by light; baby can sit, stands, walk and the time retardation spoken, and raw within latter 4 months, still can not come back, even 3-4 year also can not walk; it is characterized in that the flesh power of vastus medials group and knee flexing flesh group strengthens; normal two legs that formed intersect lopsided, are scissors gait during walking, and tendon reflex is hyperfunction; ankle or kneecap clonic spasm occur; pathology reflection is positive, and intelligence is normally or close to normal, sensation is normally. (2) brothers Xu ejector half: infant performance is not from and the autokinesis dynamic without object brothers Xu of advocating peace, far-end of limb nearer end is remarkable, produces tension force in various degree and posture because of emotion change, aggravates during active movement, alleviating during sleep or disappear, reflection is normal with flesh power.(3) ataxia type: infant shows as dysequilibrium, action is inharmonious, lurchs, and often with ocular ataxy, language intermittently, hyporeflexia, severe patient can not sitting, mental retardation. (4) mixed type: showing as above two types or the merging existence of three types, the most common with spasm type and brothers' type, intelligence is all lower.
2 methods for the treatment of
2.1 oral medicinal herb
Combination of oral medication (embodiment 1 pharmaceutical composition lot number 20110523), three times on the one, each 0.3g. 30 days courses for the treatment of.
2.2 acupuncture treatments
The rules for the treatment of: function of spleen and stomach regulating, strengthen muscles and bones, clearing and activating the channels and collaterals. Acupoint selection: the middle part of gastric cavity, Pishu, stomach Yu, liver Yu, kidney Yu, heart Yu, Huantiao, volt rabbit, tsu san li, Yinlingch'uan (He-Sea point, Sp 9), sp 6, Qiuxu, Quchi, shou san li, Wai Guan, hundred meetings etc. Select 5-7 cave to be advisable, uniform reinforcing-reducing method every time. Every day 1 time was for 30 times 1 course for the treatment of.
2.3 massage treatment
The limbs strengthened by muscular tension adopt the way of holding something, rub method stranding method etc. and loosen gimmick; Muscular tension is weakened place employing press wait stimulate heavier gimmick, then limbs are carried out in normal scope of activity passive activity, finally execution pinch ridge method. Operate 1 every day, each 15-30min, it was for 30 times 1 course for the treatment of.
2.4 home care
Infant is except carrying out except regular treatment training in hospital every day, and after going home, the head of a family should coordinate positive, simple, interesting, accurate, lasting rehabilitation training, and infant that is spasm is heavier or joint deformity uses orthopedic support to make limbs be in normal position after training.
3 results for the treatment of
3.1 effective evaluation
Evaluate by motor function and daily life active ability two aspects.
3.1.1 motor function
The motion being less than 3 years old comprises new line, stands up, lift on two legs and alternately stretch, sit, climb, stand, squat, rise and sit, walk and co-ordinate motion etc.; The motion being greater than 3 years old comprise kneel, hold up station, solely station, sitting alone, hold up away, solely walk, hold up upstairs, solely upper downstairs, bend over lost article found and co-ordinate motion (sitting posture, gait, single feet station are stood and refer to function) etc. It is respectively 10 points by 2 age brackets. After treatment, raising 3 is divided into effective; Improving 1 to be divided into effectively, less than 1 point is invalid.
3.1.2 daily life active ability presses infant
People's health, feed action, action of changing one's clothes, arrange just action, utensil uses, 10 points of evaluations are counted in cognitive exchange action, bed exercise, mobile action, walking etc. After treatment, raising 3 is divided into effective; Improving 1 after treatment is divided into effectively; Less than 1 point is invalid.
3.2 result for the treatment of
By carrying out efficacy evaluation at the end of each course for the treatment of.
3.2.1 motor function
In 20 example brain paralysis, it is less than 3 years old person 13 example, effective 10 examples, effective 3 examples. It is greater than more than 3 years old person 7 example, effective 4 examples, effective 2 examples, invalid 1 example. Always there is efficiency 95.00%.
3.2.2 daily life active ability
In 20 example brain paralysis, it is less than 3 years old person 13 example, effective 7 examples, effective 6 examples. It is greater than more than 3 years old person 7 example, effective 2 examples, effective 3 examples, invalid 2 examples. Always there is efficiency 90.00%.
Claims (8)
1. prevent and treat the pharmaceutical composition of cerebral palsy of children for one kind, it is characterised in that composition and the weight part of making the bulk drug of this pharmaceutical composition be:
Alkali 146-148 weight part peonidin 142-144 weight part determined by root of Sampsonii hance 1920-1940 weight part dust flower bud 2900-2920 weight part pilea mongolica 2490-2498 weight part different fennel celery coumarin 1 50-154 weight part mountain edge grass.
2. a kind of pharmaceutical composition preventing and treating cerebral palsy of children according to claim 1, it is characterised in that composition and the weight part of making the bulk drug of this pharmaceutical composition be:
Alkali 147 weight part peonidin 143 weight part determined by root of Sampsonii hance 1930 weight part dust flower bud 2910 weight part pilea mongolica 2494 weight part different fennel celery coumarin 1 52 weight part mountain edge grass.
3. a kind of pharmaceutical composition preventing and treating cerebral palsy of children according to claim 1, it is characterised in that pharmaceutical composition can adopt the ordinary method of technology of pharmaceutics be prepared into tablet or capsule or drip ball.
4. a kind of pharmaceutical composition preventing and treating cerebral palsy of children according to claim 1, it is characterised in that pharmaceutical composition and the control cerebral palsy of children medicine of chemistry medicine or Chinese medicine composition.
5. prevent and treat the preparation method of the pharmaceutical composition of cerebral palsy of children for one kind, it is characterised in that prepare as follows:
The composition of bulk drug and weight part be: alkali 146-148 weight part peonidin 142-144 weight part determined by edge grass in root of Sampsonii hance 1920-1940 weight part dust flower bud 2900-2920 weight part pilea mongolica 2490-2498 weight part different fennel celery coumarin 1 50-154 weight part mountain;
Preparation method:
(1) Ai Lei is got by bulk drug proportioning, pilea mongolica, root of Sampsonii hance, different fennel celery tonka bean camphor, alkali determined by mountain edge grass, peonidin, mixed even, with weight percent concentration 28% ethanol as solvent, get 28 DEG C of warm lixiviates, extraction time is 5 times, each extraction time is 18 hours, each solvent load is 19 times of bulk drug gross weight, filter, obtain dregs of a decoction A and extracting solution A, extracting solution A reclaims ethanol, concentrate to relative density 1.18, filter, liquid is by D743 macroporous adsorptive resins, first wash with water, again with weight percent concentration 49% ethanolic soln wash-out D743 macroporous adsorptive resins, collect weight percent concentration 49% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) dregs of a decoction A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 2 times, each extraction time is 1.5 hours, each solvent load is 14 times of dregs of a decoction A weight, filter, obtain dregs of a decoction B and extracting solution B, extracting solution B reclaims ethanol, concentrate to relative density 1.16, filter, liquid is by D807 macroporous adsorptive resins, first wash with water, again with weight percent concentration 67% ethanolic soln wash-out D807 macroporous adsorptive resins, collect weight percent concentration 67% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract B,
(3) extract A and extract B are mixed even, obtain pharmaceutical composition.
6. the preparation method of a kind of pharmaceutical composition preventing and treating cerebral palsy of children according to claim 5, it is characterised in that prepare as follows:
The composition of bulk drug and weight part be: alkali 147 weight part peonidin 143 weight part determined by edge grass in root of Sampsonii hance 1930 weight part dust flower bud 2910 weight part pilea mongolica 2494 weight part different fennel celery coumarin 1 52 weight part mountain;
Preparation method:
(1) Ai Lei is got by bulk drug proportioning, pilea mongolica, root of Sampsonii hance, different fennel celery tonka bean camphor, alkali determined by mountain edge grass, peonidin, mixed even, with weight percent concentration 28% ethanol as solvent, get 28 DEG C of warm lixiviates, extraction time is 5 times, each extraction time is 18 hours, each solvent load is 19 times of bulk drug gross weight, filter, obtain dregs of a decoction A and extracting solution A, extracting solution A reclaims ethanol, concentrate to relative density 1.18, filter, liquid is by D743 macroporous adsorptive resins, first wash with water, again with weight percent concentration 49% ethanolic soln wash-out D743 macroporous adsorptive resins, collect weight percent concentration 49% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) dregs of a decoction A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 2 times, each extraction time is 1.5 hours, each solvent load is 14 times of dregs of a decoction A weight, filter, obtain dregs of a decoction B and extracting solution B, extracting solution B reclaims ethanol, concentrate to relative density 1.16, filter, liquid is by D807 macroporous adsorptive resins, first wash with water, again with weight percent concentration 67% ethanolic soln wash-out D807 macroporous adsorptive resins, collect weight percent concentration 67% ethanol eluate, reclaim ethanol, concentrate drying, obtain extract B,
(3) extract A and extract B are mixed even, obtain pharmaceutical composition.
7. the preparation method of a kind of pharmaceutical composition preventing and treating cerebral palsy of children according to claim 5, it is characterised in that pharmaceutical composition can adopt the ordinary method of technology of pharmaceutics be prepared into tablet or capsule or drip ball.
8. the preparation method of a kind of pharmaceutical composition preventing and treating cerebral palsy of children according to claim 5, it is characterised in that pharmaceutical composition and chemistry medicine or Chinese medicine composition control cerebral palsy of children medicine.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728194A (en) * | 2016-12-10 | 2017-05-31 | 济南昊雨青田医药技术有限公司 | Treat pharmaceutical composition of Children with Mycoplasma Pneumonia and preparation method thereof |
| CN106729029A (en) * | 2016-12-10 | 2017-05-31 | 济南昊雨青田医药技术有限公司 | It is a kind of to treat pharmaceutical composition of cold in children and preparation method thereof |
-
2016
- 2016-01-25 CN CN201610047238.9A patent/CN105663227A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728194A (en) * | 2016-12-10 | 2017-05-31 | 济南昊雨青田医药技术有限公司 | Treat pharmaceutical composition of Children with Mycoplasma Pneumonia and preparation method thereof |
| CN106729029A (en) * | 2016-12-10 | 2017-05-31 | 济南昊雨青田医药技术有限公司 | It is a kind of to treat pharmaceutical composition of cold in children and preparation method thereof |
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