CN106729029A - It is a kind of to treat pharmaceutical composition of cold in children and preparation method thereof - Google Patents

It is a kind of to treat pharmaceutical composition of cold in children and preparation method thereof Download PDF

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Publication number
CN106729029A
CN106729029A CN201611132969.XA CN201611132969A CN106729029A CN 106729029 A CN106729029 A CN 106729029A CN 201611132969 A CN201611132969 A CN 201611132969A CN 106729029 A CN106729029 A CN 106729029A
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weight portion
ethanol
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pharmaceutical composition
percent concentration
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不公告发明人
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/20—Aceraceae (Maple family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Abstract

Pharmaceutical composition of cold in children and preparation method thereof is treated the invention discloses a kind of, pharmaceutical composition of the present invention is with peonidin, lady's-grass, moth tree, acetovanillone, veratrosin, β irisones as bulk drug, proportioning is formed, routinely various formulations can be made by preparation process, treatment cold in children is evident in efficacy.

Description

It is a kind of to treat pharmaceutical composition of cold in children and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for treating cold in children and its preparation side Method.
Background technology
Cold in children heating is Pediatric Clinic common frdquently encountered disease, accounts for pediatric disease larger specific gravity, refers to causing because of flu Pathologic body temperature raise, this is systemic reaction of the human body to virulence factor.The course of disease length and coincident with severity degree of condition are not One, some infants occur prolonged low grade fever phenomenon, and the state of an illness is touching refractory, and serious harm is brought to infant is healthy, need Effective ways are taken to treat in time.In children's internal disease, cold, fever accounts for larger specific gravity, and the disease is generally by bacterium or virus Infection causes, and immunization programs for children power is poor, and bacterium, virus infraction are easily received when resistance declines, so that body temperature pathologic liter after flu Height, clinical manifestation mainly has tic, coma etc..Cold in children heating is favorably also harmful to body, adstante febre immune function of human body , there is the resistance reaction to external disease factor or virulence factor in enhancing, can remove pathogen, promotes rehabilitation, the reaction The typically Early manifestation of serious disease.Therefore, should in time take effective ways to treat cold, fever infant, make its body Temperature recovers normal.
Lady's-grass：It is grass family knotgrass plant Digitaria sanguinalis Digitaria sanguinalis (L.) Scop. [Panicum Sangui-nale L.] herb.Summer, autumn tap herb, dry.【Nature and flavor】It is sweet；It is cold.【Indication】Improving eyesight moistening lung.It is main Mesh is secretly failed to understand；Cough with lung heat.【Proterties】Dry herb 40-100cm long.Stalk branch, takes root on the section of bottom.Intact leaf strip is draped over one's shoulders Aciculiform, 8-17cm long, 5-15mm wide, tip is tapering or short point.Base portion blunt circle, two sides is without hair or sparsely grow pubescence, loose armful of leaf sheath Stem, without hair or sparsely grow pubescence.【Former phytomorph】Lady's-grass, annual herb, culm base is often inclined, and is easily taken root after soil, high 40-100cm.Footpath 2-3mm.Leaf sheath Chang Shusheng has the fur of wart base, dilute without hair；Tip of a leaf 1-3mm long；Blade wire lanceolar is long 8-17cm, 5-15mm wide, two sides are dredged by fur or without hair, and edge is thickening and coarse.Raceme is thin and delicate, 3-10 pieces, 5- long 15cm, is generally arranged in stalk top into finger-like, and cob about 1mm wide, middle rib white accounts for the 1/3 of width；Small spike length 3-3.5mm, drapes over one's shoulders Aciculiform, twin cob is respectively saved, and one has long handle, and one has extremely short handle or a few stockless；1st clever obtuse triangle, is about 0.2mm, acrotism, The 1/2-3/4 of the 2nd clever a length of small ear, it is narrow, have between very unconspicuous 3 arteries and veins, arteries and veins and edge has short cilium mostly；1st lemma with Small ear is isometric, there is a 5-7 arteries and veins, and central 3 veinclearing shows, between arteries and veins distance it is wider and without hair, side form is very approached, sometimes not substantially, without hair or The adhesion pubescence between arteries and veins, the 2nd lemma nearly keratin, celadon is waited and is longer than the 1st lemma；Flower pesticide is about 1mm.Flower, the fruiting period 6-9 months.Receive It is loaded in dictionary of medicinal plant.
Moth tree：Pueraria lobota trailing plants maple Acer grosseri Pax var.hersii are split for Aceraceae Acer plants are long（Rehd.） Rehd. the spray and fruit of ［ A.hersii Rehd. ］.9-10 month picking fruits, dry；The 6-7 months harvest spray, dry.【Property Taste】It is bitter；It is salty；It is flat.【Indication】Cough-relieving；Sore.The new chronic cough of master is coughed；Thrush.【Original shape state】It is tall that length splits Pueraria lobota trailing plants maple fallen leaves Wood, up to 8m.Bark is filbert, smooth；Annual shoot green or purple green, perennial branch lark or taupe, leaf opposite； Petiole 2-3cm long, it is thin thin, without hair；Blade papery, avette, 7-9cm long, 5-6cm wide, edge has close and sharp heavy sawtooth, first Hold sharp point, base portion to be bordering on heart-shaped, often deeper 3 and split, central sliver is larger, and triangular shape is avette, above bottle green, without hair；Under Face light green, is then come off always in vein base portion when tender by faint yellow feathering；Base goes out 3, arteries and veins, lateral vein pinniform.Flower unisexuality, male and female are different Strain, often into thin thin sagging raceme；Sepal 5；Petal 5；Stamen 8, without hair, the agensis in female flower；Floral disc is located at stamen Inner side；Ovary purple, the agensis in male flower.Bennet 3-4mm long.Lavender, ripe rear yellowish-brown during samara children；Pyrene is micro- flat Flat, together with pyrene 2.5-2.9cm long, about 5mm wide or is bordering on level at flare up obtuse angle to wing.April at florescence, fruiting period September.Record In dictionary of medicinal plant.
Peonidin (Peonidin):CAS 26838-13-1, molecular formula C22H23ClO11, molecular weight 498.87. 【Pharmacological action】Anti-inflammatory.【Ingredient origin】Ericaceae Andromeda berry, yak Er Miao section's Pelargoniums and Paeoniaceae Chinese herbaceous peony During category is spent.
Acetovanillone（Acetovanillone）：CAS 498-02-2, molecular formula C9H10O3, molecular weight 166.18.【Medicine Reason is acted on】Choleretic effect is shown as to rabbit.There are contraction rat uterus and suppress the frog heart and act on.【Purposes】It is stable, cholagogic, effect In uterus.【Ingredient origin】Ginseng section plant Huang side Picrorrhiza kurrooa Royle ex Benth, Apocynaceae is planted Thing, apocynum cannabinum Apocynum cannabinum L. rhizomes, Androsace umbellata leaf tea flower Apocynum Androsaemifolium Linn. rhizomes.
Veratrosin（Veratrosine）：CAS 475-00-3, molecular formula C33H49NO7, molecular weight 571.74.【It is biological Activity】Anti-hypertension.【Ingredient origin】American hellebore Veratrum viride, hair leaf black false hellebore Veratrum grandiflorum。
Alpha, beta-lonone（Irisone）：CAS 14901-07-6, molecular formula C13H20O, molecular weight 192.30.【Biology is living Property】Spices.【Ingredient origin】Almond Prunus armeniaca, banksia rose Saussurea lappa [Syn.Aucklandia Lappa], fruit of Chinese wolfberry Lycium chinense.
4 chemical constitutions of bulk drug：
Veratrosin（Veratrosine）Peonidin (Peonidin)
Acetovanillone（Acetovanillone）Alpha, beta-lonone（Irisone）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition of effective treatment cold in children And preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition of the treatment cold in children be：
Peonidin 25-35 weight portion lady's-grass 460-480 weight portion moth tree 326-328 weight portion acetovanillones 8-10 Weight portion veratrosin 4-6 weight portion alpha, beta-lonone 1-2 weight portions.
The pharmaceutical composition for the treatment of cold in children is preferably used in, is made up of the bulk drug of following weight portion：
The weight portion veratrosin of 30 weight portion lady's-grass of peonidin, 470 327 weight portion acetovanillone of weight portion moth tree 9 The weight portion of 5 weight portion alpha, beta-lonone 1.5.
A kind of pharmaceutical composition for treating cold in children, it is characterised in that pharmaceutical composition can be using the routine of galenic pharmacy Method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for treating cold in children, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine Treatment cold in children medicine.
A kind of preparation method of the pharmaceutical composition for treating cold in children, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Peonidin 25-35 weight portion lady's-grass 460-480 weight portion moth trees 326- 328 weight portion acetovanillone 8-10 weight portion veratrosin 4-6 weight portion alpha, beta-lonone 1-2 weight portions；
Preparation method：
（1）Peonidin, lady's-grass, moth tree, acetovanillone, veratrosin, alpha, beta-lonone are taken by bulk drug proportioning, is mixed It is even, with the ethanol of weight percent concentration 27.5% as solvent, taken in 28.5 DEG C of temperature extractions, extraction time is 17 times, is extracted every time Time is 42 hours, and each solvent load is 67 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A is returned Ethanol is received, relative density 1.07 is concentrated into, filtered, liquid is first washed with water, then use weight by H103 large pore resin absorption columns The ethanol solution of percent concentration 22.5% elutes H103 large pore resin absorption columns, collects the ethanol elution of weight percent concentration 22.5% Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 14 times is carried every time Take the time for 0.3 when, each solvent load is 40 times of dregs of a decoction A weight, filtration, obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed Ethanol, is concentrated into relative density 1.13, and filtration, liquid is first washed with water, then use weight by XAD-1 large pore resin absorption columns The ethanol solution of percent concentration 78% elutes XAD-1 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 78%, Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for treating cold in children, it is characterised in that make as follows It is standby：
The composition and weight portion of bulk drug be：The weight portion of 30 weight portion lady's-grass of peonidin, 470 weight portion moth tree 327 The weight portion of 9 weight portion veratrosin of acetovanillone, 5 weight portion alpha, beta-lonone 1.5；
Preparation method：
（1）Peonidin, lady's-grass, moth tree, acetovanillone, veratrosin, alpha, beta-lonone are taken by bulk drug proportioning, is mixed It is even, with the ethanol of weight percent concentration 27.5% as solvent, taken in 28.5 DEG C of temperature extractions, extraction time is 17 times, is extracted every time Time is 42 hours, and each solvent load is 67 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A is returned Ethanol is received, relative density 1.07 is concentrated into, filtered, liquid is first washed with water, then use weight by H103 large pore resin absorption columns The ethanol solution of percent concentration 22.5% elutes H103 large pore resin absorption columns, collects the ethanol elution of weight percent concentration 22.5% Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 14 times is carried every time Take the time for 0.3 when, each solvent load is 40 times of dregs of a decoction A weight, filtration, obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed Ethanol, is concentrated into relative density 1.13, and filtration, liquid is first washed with water, then use weight by XAD-1 large pore resin absorption columns The ethanol solution of percent concentration 78% elutes XAD-1 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 78%, Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for treating cold in children, it is characterised in that pharmaceutical composition can be using system The conventional method of agent prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for treating cold in children, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine composition treatment cold in children medicine.
Medicine composite for curing cold in children is evident in efficacy.
Specific embodiment
Embodiment 1：Treat pharmaceutical composition of cold in children and preparation method thereof
Treat cold in children pharmaceutical composition bulk drug composition and weight portion be：Peonidin 30g lady's-grass 470g Moth tree 327g acetovanillone 9g veratrosin 5g alpha, beta-lonones 1.5g；
Preparation method：
（1）Peonidin, lady's-grass, moth tree, acetovanillone, veratrosin, alpha, beta-lonone are taken by bulk drug proportioning, is mixed It is even, with the ethanol of weight percent concentration 27.5% as solvent, taken in 28.5 DEG C of temperature extractions, extraction time is 17 times, is extracted every time Time is 42 hours, and each solvent load is 67 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A is returned Ethanol is received, relative density 1.07 is concentrated into, filtered, liquid is first washed with water, then use weight by H103 large pore resin absorption columns The ethanol solution of percent concentration 22.5% elutes H103 large pore resin absorption columns, collects the ethanol elution of weight percent concentration 22.5% Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 14 times is carried every time Take the time for 0.3 when, each solvent load is 40 times of dregs of a decoction A weight, filtration, obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed Ethanol, is concentrated into relative density 1.13, and filtration, liquid is first washed with water, then use weight by XAD-1 large pore resin absorption columns The ethanol solution of percent concentration 78% elutes XAD-1 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 78%, Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Treat pharmaceutical composition of cold in children and preparation method thereof
Treat cold in children pharmaceutical composition bulk drug composition and weight portion be：Peonidin 25g lady's-grass 480g Moth tree 326g acetovanillone 10g veratrosin 4g alpha, beta-lonones 2g；
Preparation method：
（1）Peonidin, lady's-grass, moth tree, acetovanillone, veratrosin, alpha, beta-lonone are taken by bulk drug proportioning, is mixed It is even, with the ethanol of weight percent concentration 27.5% as solvent, taken in 28.5 DEG C of temperature extractions, extraction time is 17 times, is extracted every time Time is 42 hours, and each solvent load is 67 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A is returned Ethanol is received, relative density 1.07 is concentrated into, filtered, liquid is first washed with water, then use weight by H103 large pore resin absorption columns The ethanol solution of percent concentration 22.5% elutes H103 large pore resin absorption columns, collects the ethanol elution of weight percent concentration 22.5% Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 14 times is carried every time Take the time for 0.3 when, each solvent load is 40 times of dregs of a decoction A weight, filtration, obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed Ethanol, is concentrated into relative density 1.13, and filtration, liquid is first washed with water, then use weight by XAD-1 large pore resin absorption columns The ethanol solution of percent concentration 78% elutes XAD-1 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 78%, Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Treat pharmaceutical composition of cold in children and preparation method thereof
Treat cold in children pharmaceutical composition bulk drug composition and weight portion be：Peonidin 35g lady's-grass 460g Moth tree 328g acetovanillone 8g veratrosin 6g alpha, beta-lonones 1g；
Preparation method：
（1）Peonidin, lady's-grass, moth tree, acetovanillone, veratrosin, alpha, beta-lonone are taken by bulk drug proportioning, is mixed It is even, with the ethanol of weight percent concentration 27.5% as solvent, taken in 28.5 DEG C of temperature extractions, extraction time is 17 times, is extracted every time Time is 42 hours, and each solvent load is 67 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A is returned Ethanol is received, relative density 1.07 is concentrated into, filtered, liquid is first washed with water, then use weight by H103 large pore resin absorption columns The ethanol solution of percent concentration 22.5% elutes H103 large pore resin absorption columns, collects the ethanol elution of weight percent concentration 22.5% Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 14 times is carried every time Take the time for 0.3 when, each solvent load is 40 times of dregs of a decoction A weight, filtration, obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed Ethanol, is concentrated into relative density 1.13, and filtration, liquid is first washed with water, then use weight by XAD-1 large pore resin absorption columns The ethanol solution of percent concentration 78% elutes XAD-1 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 78%, Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 277g of Example 1, adds starch 130g, mixes, and granulation is dried, plus microcrystalline cellulose 72g, stearic Sour magnesium 5g, mixes, and is pressed into 1600, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 208g of Example 2, adds starch 231g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid Magnesium, mixes, and encapsulated 1600, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 370g water-baths and boil molten, add the pharmaceutical composition 11g of embodiment 3, fully stir Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is -5 DEG C, and drip internal-and external diameter is 7.0/ 2.0 (mm/mm), drip is 2.3cm away from liquid level, and drop speed is optimum condition with every point 50 drop, and the cold of dripping pill surface is blotted with cotton Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：Treat the pharmaceutical composition of cold in children
Treat cold in children pharmaceutical composition bulk drug composition and weight portion be：
The weight portion of 30 weight portion alpha, beta-lonone of peonidin 20 weight portion acetovanillone, 20 weight portion veratrosin 10.
Embodiment 8：Treat the pharmaceutical composition of cold in children
Treat cold in children pharmaceutical composition bulk drug composition and weight portion be：
The weight portion of 25 weight portion alpha, beta-lonone of peonidin 30 weight portion acetovanillone, 10 weight portion veratrosin 12.
Embodiment 9：Treat the pharmaceutical composition of cold in children
Treat cold in children pharmaceutical composition bulk drug composition and weight portion be：
The weight portion of 10 weight portion alpha, beta-lonone of peonidin 23 weight portion acetovanillone, 50 weight portion veratrosin 8.
Experimental example 1：Treat the experimental study of cold in children
1 physical data and method
1.1 physical data
36 cold, fever infants of in December, 2013~2014 year November this city hospitalize are chosen as research object, 18 Man, 18 female, at 2~9 years old age, generate heat 38 DEG C of ＞.All infants meet traditional Chinese medical science cold in children and wind-heat criminal table, heat after diagnosing Heat attacks table TCM syndrome diagnostic criteria, without serious diseases such as cardiovascular and cerebrovascular, liver kidney, internal systems.Infant is divided at random being ground Study carefully group and control group, every group each 18.Before treatment, two groups of infants do not take any medicine, sex, age, clinical symptoms etc. Physical data aspect no difference of science of statistics meaning（P ＞ 0.05）, with comparative.
1.2 methods
1.2.1 seminar
Seminar's infant uses pharmaceutical composition（The pharmaceutical composition of embodiment 1）Treat, specific treatment is：Taken according to children age With suitable dosage, i.e., take daily 3 times, each 2-5 Sui infant takes 0.4g, ＞ takes 0.7g for 5 years old, and the course for the treatment of is 3-7 days.
1.2.2 control group
Seminar's infant uses children's return of spring particle（Antai Pharmaceutical Co., Ltd., Guizhou Prov., Chinese medicines quasi-word Z20054559）Treatment, tool Body is treated：Suitable dosage is taken according to children age, i.e., is taken daily 3 times, each 2-5 Sui infant takes 1g, ＞ takes for 5 years old 1.5g, the course for the treatment of is 3-7 days.
1.3 efficacy assessment standards
During the two groups of infant medications of detailed observed and recorded situations such as clinical symptoms improvement, adverse reaction, reference《New Chinese medicine faces Bed research guideline》Evaluation clinical efficacy, curative effect after being treated with recovery from illness, effective, effective, invalid representation infant.
Recovery from illness：After medication 2d, infant clinical symptoms are wholly absent, and body temperature recovers normal completely, does not recur；
It is effective：After medication 2d, infant clinical symptoms are obviously improved, and body temperature is returned to normal, and are not recurred；
Effectively：After medication 2-3d, infant clinical symptoms are obviously improved, and body temperature substantially recovers normal, occasionally there is recurrence；
It is invalid：After medication, infant clinical symptoms, body temperature are not improved or aggravate, frequent recurrence.
Will recovery from illness, it is effective, effectively as the total effectively situation of infant treatment.
1.4 statistical methods
All datas are analyzed and processed using SPSS18.0 statistics softwares, enumeration data Chi-square Test, continuous data with （X ± s）Represent, measurement data is checked with t, P ＜ 0.05 show there is significant difference meaning.
2 results
2.1 two groups of clinical efficacy contrasts
Two groups of cold, fever infants complete treatment, and seminar is total effective 18 after treatment, accounts for 100%；Control group total effective 15 Example, accounts for 83.33%, two groups of total effective rates contrasts, and seminar is apparently higher than control group.
1 two groups of clinical efficacy contrasts of table（%）
Group Number of cases Recovery from illness It is effective Effectively It is invalid Total effective rate %
Seminar 18 5 9 4 0 100
Control group 18 6 5 4 3 83.33
Note：With control group contrast, P values ＜ 0.05.
2.2 two groups of adverse reaction contrasts
During treatment, none adverse drug reaction of seminar occurs, and control group occurs 2 adverse drug reactions, adverse reaction It is vomiting, is not required to be processed, can be voluntarily taken a turn for the better in 8h.Two groups of rate of adverse reactions contrasts, seminar is substantially low In control group.

Claims (8)

1. a kind of pharmaceutical composition for treating cold in children, it is characterised in that be made the bulk drug of the pharmaceutical composition composition and Weight portion is：
Peonidin 25-35 weight portion lady's-grass 460-480 weight portion moth tree 326-328 weight portion acetovanillones 8-10 Weight portion veratrosin 4-6 weight portion alpha, beta-lonone 1-2 weight portions.
2. a kind of pharmaceutical composition for treating cold in children according to claim 1, it is characterised in that be made the drug regimen The composition and weight portion of the bulk drug of thing be：
The weight portion veratrosin of 30 weight portion lady's-grass of peonidin, 470 327 weight portion acetovanillone of weight portion moth tree 9 The weight portion of 5 weight portion alpha, beta-lonone 1.5.
3. a kind of pharmaceutical composition for treating cold in children according to claim 1, it is characterised in that pharmaceutical composition can be with Piece agent or capsule or dripping pill are prepared using the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition for treating cold in children according to claim 1, it is characterised in that pharmaceutical composition with change Learn the treatment cold in children medicine of medicine or Chinese medicine composition.
5. a kind of preparation method of the pharmaceutical composition for treating cold in children, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Peonidin 25-35 weight portion lady's-grass 460-480 weight portion moth trees 326- 328 weight portion acetovanillone 8-10 weight portion veratrosin 4-6 weight portion alpha, beta-lonone 1-2 weight portions；
Preparation method：
（1）Peonidin, lady's-grass, moth tree, acetovanillone, veratrosin, alpha, beta-lonone are taken by bulk drug proportioning, is mixed It is even, with the ethanol of weight percent concentration 27.5% as solvent, taken in 28.5 DEG C of temperature extractions, extraction time is 17 times, is extracted every time Time is 42 hours, and each solvent load is 67 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A is returned Ethanol is received, relative density 1.07 is concentrated into, filtered, liquid is first washed with water, then use weight by H103 large pore resin absorption columns The ethanol solution of percent concentration 22.5% elutes H103 large pore resin absorption columns, collects the ethanol elution of weight percent concentration 22.5% Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 14 times is carried every time Take the time for 0.3 when, each solvent load is 40 times of dregs of a decoction A weight, filtration, obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed Ethanol, is concentrated into relative density 1.13, and filtration, liquid is first washed with water, then use weight by XAD-1 large pore resin absorption columns The ethanol solution of percent concentration 78% elutes XAD-1 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 78%, Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for treating cold in children according to claim 5, it is characterised in that by such as It is prepared by lower step：
The composition and weight portion of bulk drug be：The weight portion of 30 weight portion lady's-grass of peonidin, 470 weight portion moth tree 327 The weight portion of 9 weight portion veratrosin of acetovanillone, 5 weight portion alpha, beta-lonone 1.5；
Preparation method：
（1）Peonidin, lady's-grass, moth tree, acetovanillone, veratrosin, alpha, beta-lonone are taken by bulk drug proportioning, is mixed It is even, with the ethanol of weight percent concentration 27.5% as solvent, taken in 28.5 DEG C of temperature extractions, extraction time is 17 times, is extracted every time Time is 42 hours, and each solvent load is 67 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A is returned Ethanol is received, relative density 1.07 is concentrated into, filtered, liquid is first washed with water, then use weight by H103 large pore resin absorption columns The ethanol solution of percent concentration 22.5% elutes H103 large pore resin absorption columns, collects the ethanol elution of weight percent concentration 22.5% Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 14 times is carried every time Take the time for 0.3 when, each solvent load is 40 times of dregs of a decoction A weight, filtration, obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed Ethanol, is concentrated into relative density 1.13, and filtration, liquid is first washed with water, then use weight by XAD-1 large pore resin absorption columns The ethanol solution of percent concentration 78% elutes XAD-1 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 78%, Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for treating cold in children according to claim 5, it is characterised in that medicine Composition can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition for treating cold in children according to claim 5, it is characterised in that medicine Composition and chemical drugs or Chinese medicine composition treatment cold in children medicine.
CN201611132969.XA 2016-12-10 2016-12-10 It is a kind of to treat pharmaceutical composition of cold in children and preparation method thereof Withdrawn CN106729029A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105497096A (en) * 2016-01-25 2016-04-20 济南星懿医药技术有限公司 Medicine composition for treating liver ascites and preparation method thereof
CN105663227A (en) * 2016-01-25 2016-06-15 济南星懿医药技术有限公司 Drug combination for preventing and treating infantile cerebral palsy and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105497096A (en) * 2016-01-25 2016-04-20 济南星懿医药技术有限公司 Medicine composition for treating liver ascites and preparation method thereof
CN105663227A (en) * 2016-01-25 2016-06-15 济南星懿医药技术有限公司 Drug combination for preventing and treating infantile cerebral palsy and preparation method thereof

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