CN106727790A - A kind of pharmaceutical composition for treating tonsillitis - Google Patents

A kind of pharmaceutical composition for treating tonsillitis Download PDF

Info

Publication number
CN106727790A
CN106727790A CN201611133059.3A CN201611133059A CN106727790A CN 106727790 A CN106727790 A CN 106727790A CN 201611133059 A CN201611133059 A CN 201611133059A CN 106727790 A CN106727790 A CN 106727790A
Authority
CN
China
Prior art keywords
weight
ethanol
pharmaceutical composition
extract
percent concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201611133059.3A
Other languages
Chinese (zh)
Inventor
不公告发明人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jinan Haoyu Qingtian Medicine Technology Co ltd
Original Assignee
Jinan Haoyu Qingtian Medicine Technology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jinan Haoyu Qingtian Medicine Technology Co ltd filed Critical Jinan Haoyu Qingtian Medicine Technology Co ltd
Priority to CN201611133059.3A priority Critical patent/CN106727790A/en
Publication of CN106727790A publication Critical patent/CN106727790A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Pharmaceutical composition of tonsillitis and preparation method thereof is treated the invention discloses a kind of, pharmaceutical composition of the present invention is with szechwan-Yunnan sanicle herb, Guangxi dog tartar, cycloartanol, acrifoline as bulk drug, proportioning is formed, routinely various formulations can be made by preparation process, treatment tonsillitis is evident in efficacy.

Description

A kind of pharmaceutical composition for treating tonsillitis
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for treating tonsillitis and its preparation side Method.
Background technology
Suppurative tonsillitis is children's common disease, mainly caused by bacterium infection, if treatment is not in time, can cause gas The diseases such as Guan Yan, rheumatic fever, glomerulonephritis, myocarditis.Suppurative tonsillitis is common disease in children, frequently-occurring disease, clinical table Now for hyperpyrexia, abscess of throat, hypertrophy of tonsils etc., have a strong impact on that children are healthy and life study.Pathogen is generally Hemolytic streptococcus, staphylococcus, pneumococcus, therefore western medical treatment first-selection antibiotic therapy.But in recent years due to antibiotic Abuse, many bacteriums generate different degrees of drug resistance to original drug of first choice PCs, therefore, traditional Chinese medicine is controlled Treatment advantage is emerged from.Suppurative tonsillitis belongs to traditional Chinese medicine " acute tonsillitis " category.Traditional Chinese medicine thinks, throat is belonging to lung stomach, Wind-heat evil poison is invaded, and is violated in throat；Or because exopathogen stops up Sheng, take advantage of a favourable situation in biography, lung and stomach excessive heat is burning hot above to steam；Or because addiction is pungent dry, Taste intrinsic heat, attacks in heat toxin, and it is disease that heap soil or fertilizer over and around the roots is tied in larynx core.《Throat arteries and veins card general survey acute tonsillitis the 4th》Carry:" this card is because of the hot thing of meat of being addicted to drink Excessively, heat toxin product is in blood system ... causes have this to send out its shape or left or right, red or white, shape such as nipple, therefore says acute tonsillitis ".
Szechwan-Yunnan sanicle herb：This product is samphire river Yunnan sanicle Sanicula astrantifolia Wolff ex Kresch. herb.The 6-9 months harvest, and dry.【Nature and flavor】Pungent, slight bitter, temperature.【Return through】Return liver warp.【Indication】Wind-damp dispelling； Degrading the channel.Main arthralgia pain due to rheumatism；Muscle arteries and veins contraction；Traumatic injury.【Former phytomorph】Perennial herb, 30-70cm high.Complete stool without Hair.Root tubbiness, there is most elongated supporting roots.Stem is upright, and top is stood, top 2-4 dichotomies.Basal leaf petiole 5-20cm long, base There is film quality sheath wide in portion.Blade nearly keratin, heart shaped triangle forms round kidney shape, 2.5-8cm long, 2.5-9cm wide, and palmate three is molten to be split, in Between sliver obovate wide, side sliver whip shape ovum shape lanceolar, sometimes again there is 1-2 to incise deeply, there is thick crenature at edge, and increment has Mucro, palmate vein 3-5.Universal umbel basidixed；Phyllary is several, linear；Umbrella spoke is a small number of；Involucel piece 7-10, it is linear；It is small Umbel has about 10, flower；Calyx tooth wire lanceolar；Petal obovate, white or pink；Style outwards launches.Diachenium Inverted cone-shaped, is about 2mm, below prickle it is short, top prickle in hook-shaped, golden yellow or aubergine；Mitogenetic fruit cross section is rounded, The endosperm outside of belly is straight, and oil pipe is small, not substantially.Flower, the fruiting period 7-10 months.Record in dictionary of medicinal plant.
Guangxi dog tartar：It is Apocynaceae Ervatamia plant Guangxi dog tartar Ervatamia kwangsiensis The root skin of Tsiang, leaf.Root skin whole year can adopt, and clean, using fresh herb；Leaf using fresh herb.【Nature and flavor】It is bitter；It is pungent；It is mild-natured.【Indication】Promoting blood circulation Analgesic.Main traumatic injury；Fracture swells and ache.【Former phytomorph】Shrub, up to 5m.Without hair in addition to spending；Branch and sprig have hole skin, Internode reaches 2-3cm.Expand and symphysis, oval, up to 2mm on the pretext of leaf base.Leaf opposite；Petiole 5-12mm long；Blade heavily fortified point paper Matter, ellipticity oval, 5-15cm long, 3-6.5cm wide, tip is short tapering, base portion wedge shape, surface bottle green, back side light green； Middle arteries are recessed on blade face, overleaf raised；Lateral vein 12-14 pairs, arc rises.Cyme axillary, usual two discrimination, is born in sprig Top, there is colored 6-7；Total bennet 3-4cm long；Bract and squamella oval；Spend 5 numbers：Bud cylindrical shape；Calyx is wide bell, Base portion inner face Non-gland body, sepal has echinid；Corolla white, it is caducous；Tube top covers to the left to right rotation, sliver base portion, There is micro- pubescence on two sides；Stamen is born in nearly gorge portion；The nearly arrow-shaped of flower pesticide；Column cap 2 splits.Follicle radish is twin, 150 ° of forks, round shape long Lanceolar, has short beak；Carpopodium is about 1cm, fruit 5-6cm long.There is 5-6 in seed Mei Ge Follicle radish.The month at florescence 5-9, fruiting period 9- November.Record in dictionary of medicinal plant.
Acrifoline（Acrifoline）：CAS 664-24-4, molecular formula C16H23NO2, molecular weight 261.36.【Composition Source】Selago-like climbing fern herb Huperzia selago [Syn. Lycopodium selago], 2 years lycopod Lycopodium annotinum var. acrifolium。
Cycloartanol（Cycloartanol）：CAS 4657-58-3, molecular formula C30H52O, molecular weight 428.75. 【Pharmacological action】With antiinflammatory action.【Ingredient origin】Soya-bean oil, the fruit of Chinese wolfberry, Huo Yang le, the wall fern.
2 bulk drug chemical constitutions：
Acrifoline（Acrifoline）Cycloartanol（Cycloartanol）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition of effective treatment tonsillitis And preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition of the treatment tonsillitis be：
Szechwan-Yunnan sanicle herb 1060-1070 weight portions Guangxi dog tartar 336-340 weight portion cycloartanol 112-118 weight Part acrifoline 80-100 weight portions.
The pharmaceutical composition for the treatment of tonsillitis is preferably used in, is made up of the bulk drug of following weight portion：
The weight portion acrifoline of 1,065 338 weight portion cycloartanol of weight portion Guangxi dog tartar of szechwan-Yunnan sanicle herb 116 90 weight portions.
A kind of pharmaceutical composition for treating tonsillitis, it is characterised in that pharmaceutical composition can be using the routine of galenic pharmacy Method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for treating tonsillitis, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine Treatment tonsillitis medicine.
A kind of preparation method of the pharmaceutical composition for treating tonsillitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Szechwan-Yunnan sanicle herb 1060-1070 weight portions Guangxi dog tartar 336-340 weight portions Cycloartanol 112-118 weight portion acrifoline 80-100 weight portions；
Preparation method：
（1）Szechwan-Yunnan sanicle herb, Guangxi dog tartar, cycloartanol, acrifoline are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 12 small When, each solvent load is 56 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, dense Relative density 1.16 is reduced to, is filtered, liquid is first washed with water by LKS04 large pore resin absorption columns, then dense with percentage by weight 23% ethanol solution wash-out LKS04 large pore resin absorption columns are spent, the ethanol eluate of weight percent concentration 23% is collected, second is reclaimed Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 9 times is carried every time The time is taken for 0.3 hour, each solvent load is 29 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 44% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 44% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for treating tonsillitis, it is characterised in that make as follows It is standby：
The composition and weight portion of bulk drug be：The weight portion ring jackfruit of 1065 weight portion Guangxi dog tartar of szechwan-Yunnan sanicle herb 338 The weight portion of 116 weight portion acrifoline of alkanol 90；
Preparation method：
（1）Szechwan-Yunnan sanicle herb, Guangxi dog tartar, cycloartanol, acrifoline are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 12 small When, each solvent load is 56 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, dense Relative density 1.16 is reduced to, is filtered, liquid is first washed with water by LKS04 large pore resin absorption columns, then dense with percentage by weight 23% ethanol solution wash-out LKS04 large pore resin absorption columns are spent, the ethanol eluate of weight percent concentration 23% is collected, second is reclaimed Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 9 times is carried every time The time is taken for 0.3 hour, each solvent load is 29 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 44% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 44% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for treating tonsillitis, it is characterised in that pharmaceutical composition can be using system The conventional method of agent prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for treating tonsillitis, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine composition treatment tonsillitis medicine.
Medicine composite for curing tonsillitis is evident in efficacy.
Specific embodiment
Embodiment 1：Treat pharmaceutical composition of tonsillitis and preparation method thereof
Treat tonsillitis pharmaceutical composition bulk drug composition and weight portion be：Szechwan-Yunnan sanicle herb 1065g Guangxi dog tooth Flower 338g cycloartanol 116g acrifolines 90g；
Preparation method：
（1）Szechwan-Yunnan sanicle herb, Guangxi dog tartar, cycloartanol, acrifoline are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 12 small When, each solvent load is 56 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, dense Relative density 1.16 is reduced to, is filtered, liquid is first washed with water by LKS04 large pore resin absorption columns, then dense with percentage by weight 23% ethanol solution wash-out LKS04 large pore resin absorption columns are spent, the ethanol eluate of weight percent concentration 23% is collected, second is reclaimed Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 9 times is carried every time The time is taken for 0.3 hour, each solvent load is 29 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 44% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 44% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Treat pharmaceutical composition of tonsillitis and preparation method thereof
Treat tonsillitis pharmaceutical composition bulk drug composition and weight portion be：Szechwan-Yunnan sanicle herb 1060g Guangxi dog tooth Flower 340g cycloartanol 112g acrifolines 100g；
Preparation method：
（1）Szechwan-Yunnan sanicle herb, Guangxi dog tartar, cycloartanol, acrifoline are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 12 small When, each solvent load is 56 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, dense Relative density 1.16 is reduced to, is filtered, liquid is first washed with water by LKS04 large pore resin absorption columns, then dense with percentage by weight 23% ethanol solution wash-out LKS04 large pore resin absorption columns are spent, the ethanol eluate of weight percent concentration 23% is collected, second is reclaimed Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 9 times is carried every time The time is taken for 0.3 hour, each solvent load is 29 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 44% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 44% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Treat pharmaceutical composition of tonsillitis and preparation method thereof
Treat tonsillitis pharmaceutical composition bulk drug composition and weight portion be：Szechwan-Yunnan sanicle herb 1070g Guangxi dog tooth Flower 336g cycloartanol 118g acrifolines 80g；
Preparation method：
（1）Szechwan-Yunnan sanicle herb, Guangxi dog tartar, cycloartanol, acrifoline are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 12 small When, each solvent load is 56 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, dense Relative density 1.16 is reduced to, is filtered, liquid is first washed with water by LKS04 large pore resin absorption columns, then dense with percentage by weight 23% ethanol solution wash-out LKS04 large pore resin absorption columns are spent, the ethanol eluate of weight percent concentration 23% is collected, second is reclaimed Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 9 times is carried every time The time is taken for 0.3 hour, each solvent load is 29 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 44% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 44% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 256g of Example 1, adds starch 280g, mixes, and granulation is dried, plus microcrystalline cellulose 57, stearic acid Magnesium 4g, mixes, and is pressed into 1400, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 257g of Example 2, adds starch 248g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid Magnesium, mixes, and encapsulated 1600, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 248g water-baths and boil molten, add the pharmaceutical composition 13g of embodiment 3, fully stir Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is 5 DEG C, and drip internal-and external diameter is 7.0/ 1.5 (mm/mm), drip is 1.9cm away from liquid level, and drop speed is optimum condition with every point 53 drop, and the cold of dripping pill surface is blotted with cotton Solidifying agent, obtains final product medicament composition dropping pills.
Experimental example 1：The Experiment on Function research for the treatment of tonsillitis
1 clinical data
1.1 physical data
The Hospitalized Children 60 that 2013~2015 Nian Wo cities pediatric hospitals are diagnosed as children's suppurative tonsillitis is chosen, its Middle male 30, female 30；4~12 years old age；Within course of disease 36h.It is randomly divided into two groups.Two groups in sex, age, disease The aspects such as journey compare, no significant difference (P ＞ 0.05), with comparativity.
1.2 diagnostic criteria
(1) Western medicine diagnostic criteria:Meet《All good fortune Chinese bush cherry practical paidonosologies》In " suppurative tonsillitis " diagnostic criteria.Onset It is anxious, the course of disease≤48h, body temperature >=38 DEG C, with pharyngalgia, dysphagia as cardinal symptom, visible pharyngeal mucous membrane of having a medical check-up is congested, tonsillotome Anthorisma, >=II degree, there is a purulent secretion on surface, and lymphoodi mandibulares enlargement has a tenderness, leukocyte counts >= 10.0×109/ L, neutrophil leucocyte ratio increases to 70%~90%.(2) tcm diagnosis standard:Meet《Traditional Chinese medical science hals,Nasen und Ohrenheilkunde Learn》In " acute tonsillitis " lung and stomach excessive heat card diagnostic criteria.
1.3 exclusion standards
(1) intentionally, liver, severe systemic disease or the severe dietetic patient such as kidney；(2) pharyngeal symptom is other acute infectious diseases Early stage makes winner；(3) occurred or local systemic complications person；(4) to medicine allergy sufferers, and the past compliance difference person.
2 treatment methods
2.1 general treatments
Take a good rest, drink more water, diet is light being rich in nutrition, adstante febre gives Physical temperature-lowering, brufen or right can be used during hyperpyrexia Paracetamol is brought down a fever, and vein fluid infusion supportive treatment.
2.2 control groups
Using western medicine routine treatment.Benzylpenicillin sodium salt pin 10~200,000 U/ (kgd) are given, point 2 drip-feeds, penicillin anaphylaxis Person uses Azithromycin injection 10mg/ (kgd), 1 day 1 time instead.
2.3 treatment groups
Pharmaceutical composition is given on the basis of control group treatment（The pharmaceutical composition of embodiment 1）Treatment, each 0.6g, 6~12 years old Daily 2 times of infant, 3~5 years old daily 1 time of infant.Two groups of courses for the treatment of are 5d, and curative effect is counted after treatment end.
3 observation of curative effect
3.1 observation index
Observe two groups of resolution of fever times, pharyngalgia, tonsillotome secretion extinction time and after 3d blood WBC, N%, CRP change Change and length of stay, adverse reaction.
3.2 criterions of therapeutical effect
Reference《Chinese medical disease Standardization of diagnosis and curative effect》In relevant standard draft.Cure:Heat is moved back, without pharyngalgia, tonsillotome pus point or Purulence tongue disappears；Effectively:Heating, pharyngalgia symptom mitigation, tonsillotome pus point or purulence tongue are reduced；It is invalid:Heating, pharyngalgia, almond Body pus point or purulence tongue are without improvement.
3.3 statistical methods
Statistical analysis are carried out using the statistical softwares of SPSS 17.0, measurement data is represented using (x ± s), and use is compared between group Independent sample t is checked, and enumeration data uses Chi-square Test.P ＜ 0.05 are that difference is statistically significant.
3.4 treatment results
Total effective rate treatment group is 93.33%, and control group is 73.33%, and two groups are compared, and difference is statistically significant.
1 two groups for the treatment of results of table and comparitive study (example)
Group n Cure Effectively It is invalid Total effective rate %
Treatment group 30 17 11 2 93.33*
Control group 30 9 13 8 73.33
Note:Compare with control group, * P ＜ 0.05.
3.5 two groups of cardinal symptom remission times compare
Treatment group's infant heat move back the time, pharyngalgia extinction time, secretion extinction time, in terms of the hospital stays better than control group, Compare between group, difference is statistically significant.
Blood WBC, N%, CRP compare after 3.6 treatment 3d
Two groups of WBC, N%, CRP values can decline, and treatment group reduces significantly, compares between group, statistically significant (the P ＜ of difference 0.05)。
3.7 two groups of adverse reactions are compared
There is abdominal discomfort, loose stools 0 in treatment group during treatment, and n and V 2 occurs in control group, but symptom is all relatively lighter It is micro-.

Claims (8)

1. a kind of pharmaceutical composition for treating tonsillitis, it is characterised in that be made the bulk drug of the pharmaceutical composition composition and Weight portion is：
Szechwan-Yunnan sanicle herb 1060-1070 weight portions Guangxi dog tartar 336-340 weight portion cycloartanol 112-118 weight Part acrifoline 80-100 weight portions.
2. a kind of pharmaceutical composition for treating tonsillitis according to claim 1, it is characterised in that be made the drug regimen The composition and weight portion of the bulk drug of thing be：
The weight portion acrifoline of 1,065 338 weight portion cycloartanol of weight portion Guangxi dog tartar of szechwan-Yunnan sanicle herb 116 90 weight portions.
3. a kind of pharmaceutical composition for treating tonsillitis according to claim 1, it is characterised in that pharmaceutical composition can be with Piece agent or capsule or dripping pill are prepared using the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition for treating tonsillitis according to claim 1, it is characterised in that pharmaceutical composition with change Learn the treatment tonsillitis medicine of medicine or Chinese medicine composition.
5. a kind of preparation method of the pharmaceutical composition for treating tonsillitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Szechwan-Yunnan sanicle herb 1060-1070 weight portions Guangxi dog tartar 336-340 weight portions Cycloartanol 112-118 weight portion acrifoline 80-100 weight portions；
Preparation method：
（1）Szechwan-Yunnan sanicle herb, Guangxi dog tartar, cycloartanol, acrifoline are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 12 small When, each solvent load is 56 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, dense Relative density 1.16 is reduced to, is filtered, liquid is first washed with water by LKS04 large pore resin absorption columns, then dense with percentage by weight 23% ethanol solution wash-out LKS04 large pore resin absorption columns are spent, the ethanol eluate of weight percent concentration 23% is collected, second is reclaimed Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 9 times is carried every time The time is taken for 0.3 hour, each solvent load is 29 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 44% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 44% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for treating tonsillitis according to claim 5, it is characterised in that by such as It is prepared by lower step：
The composition and weight portion of bulk drug be：The weight portion ring jackfruit of 1065 weight portion Guangxi dog tartar of szechwan-Yunnan sanicle herb 338 The weight portion of 116 weight portion acrifoline of alkanol 90；
Preparation method：
（1）Szechwan-Yunnan sanicle herb, Guangxi dog tartar, cycloartanol, acrifoline are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 12 small When, each solvent load is 56 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, dense Relative density 1.16 is reduced to, is filtered, liquid is first washed with water by LKS04 large pore resin absorption columns, then dense with percentage by weight 23% ethanol solution wash-out LKS04 large pore resin absorption columns are spent, the ethanol eluate of weight percent concentration 23% is collected, second is reclaimed Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 52% as solvent, heating and refluxing extraction 9 times is carried every time The time is taken for 0.3 hour, each solvent load is 29 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 44% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 44% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for treating tonsillitis according to claim 5, it is characterised in that medicine Composition can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition for treating tonsillitis according to claim 5, it is characterised in that medicine Composition and chemical drugs or Chinese medicine composition treatment tonsillitis medicine.
CN201611133059.3A 2016-12-10 2016-12-10 A kind of pharmaceutical composition for treating tonsillitis Withdrawn CN106727790A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201611133059.3A CN106727790A (en) 2016-12-10 2016-12-10 A kind of pharmaceutical composition for treating tonsillitis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201611133059.3A CN106727790A (en) 2016-12-10 2016-12-10 A kind of pharmaceutical composition for treating tonsillitis

Publications (1)

Publication Number Publication Date
CN106727790A true CN106727790A (en) 2017-05-31

Family

ID=58875021

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201611133059.3A Withdrawn CN106727790A (en) 2016-12-10 2016-12-10 A kind of pharmaceutical composition for treating tonsillitis

Country Status (1)

Country Link
CN (1) CN106727790A (en)

Similar Documents

Publication Publication Date Title
CN106038678A (en) Pharmaceutical composition for treating chloasma and preparation method thereof
CN106668348A (en) Pharmaceutical composition for treating diabetic retinopathy
CN106727790A (en) A kind of pharmaceutical composition for treating tonsillitis
CN105287921A (en) Medicinal composition for treating gastric cancer and preparation method thereof
CN106581431A (en) Medicine composition for preventing and treating amygdalitis
CN106728036A (en) A kind of pharmaceutical composition for preventing and treating periodontitis
CN106727776A (en) Pharmaceutical composition for treating fibroid
CN106581093A (en) Pharmaceutical composition for treating amygdalitis
CN106539833A (en) One kind treats colpitic pharmaceutical composition
CN106619771A (en) Medicine compositionc for preventing and treating hysteromyoma
CN106727788A (en) Treat pharmaceutical composition of tonsillitis and preparation method thereof
CN106727791A (en) It is a kind of to treat pharmaceutical composition of tonsillitis and preparation method thereof
CN106668124A (en) Pharmaceutical composition for preventing and treating uterine myoma and preparation method thereof
CN106727874A (en) It is a kind of to prevent and treat pharmaceutical composition of ovarian cyst and preparation method thereof
CN106729032A (en) Pharmaceutical composition for treating cold in children
CN106581103A (en) Pharmaceutical composition for prevention and treatment of vaginitis
CN106581102A (en) Pharmaceutical composition for treatment of uterine myoma
CN106852948A (en) A kind of pharmaceutical composition for treating canker sore
CN106729033A (en) A kind of pharmaceutical composition for treating cold in children
CN106729029A (en) It is a kind of to treat pharmaceutical composition of cold in children and preparation method thereof
CN106692376A (en) Pharmaceutical composition for preventing and treating vaginitis
CN106727876A (en) The pharmaceutical composition for the treatment of pulmonary tuberculosis cough
CN106511627A (en) Medicine composition for preventing and treating ovarian cyst
CN106727789A (en) The treatment cold arthritic pharmaceutical composition of rheumatism
CN105616711A (en) Medicine composition for preventing and treating schizophrenia

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20170531