CN106852948A - A kind of pharmaceutical composition for treating canker sore - Google Patents

A kind of pharmaceutical composition for treating canker sore Download PDF

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CN106852948A
CN106852948A CN201611133219.4A CN201611133219A CN106852948A CN 106852948 A CN106852948 A CN 106852948A CN 201611133219 A CN201611133219 A CN 201611133219A CN 106852948 A CN106852948 A CN 106852948A
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ethanol
pharmaceutical composition
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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Abstract

Pharmaceutical composition of canker sore and preparation method thereof is treated the invention discloses a kind of, pharmaceutical composition of the present invention is with Oblongleaf Heterostemma, katydid, Nepeta glycosides, agrimonolide as bulk drug, proportioning is formed, and routinely can be made various formulations by preparation process, and treatment canker sore is evident in efficacy.

Description

A kind of pharmaceutical composition for treating canker sore
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for treating canker sore and its preparation side Method.
Background technology
Recurrent oral ulceration belongs to traditional Chinese medicine aphtha, aphthous stomatitis category, and it occurs have close with the imbalance of heat evil, damp evil and internal organ Cut relation.Such as《The big opinion of Plain Questions gas alternation》Say：" year gold too late, people's disease aphtha that scorching fire is up ... ... ", illustrate have with heat evil Close.Spleen-QI connecting with mouth, overfeeding fatness, sweet, thick and oily usually, so that insufficiency of the spleen resulting in production of dampness, wet heap soil or fertilizer over and around the roots heat.Consumption of YIN caused by febrile disease or overstrain cause cloudy liquid not Foot, fire of deficiency type hot smoking oral cavity and send out aphtha.Damp evil stick it is greasy, should not speed go, therefore Blood of Patients with Recurrent Oral does not often recover for a long time.Near In year clinical practice, the author on the basis of dialectical, with reference to how hot, the how wet feature of Lingnan area and tcm theory " spleen master Muscle ", " spleen-QI connecting with mouth ", the spleen being blocked by dampness, the theory of insufficiency of the spleen resulting in production of dampness, it is understood that the cause of disease of Lingnan area recurrent oral ulceration Mostly heat evil, damp evil, while it was observed that, Blood of Patients with Recurrent Oral is simultaneous to see the hot hidrosis of body, restlessness and thirst, scanty drak urine, body The deficiency of both qi and yin performances such as tired few gas, lassitude, deficient and rapid pulse.Because heat is yang pathogens, easy gas consumption hinders Tianjin.Therefore Lingnan area The pathogenic characteristic of recurrent oral ulceration is " damp and hot long bridle, deficiency of both qi and yin ".Based on above-mentioned mechanism, establish with clearing away heat and eliminating dampeness, Recurrent oral ulceration is treated in nourishing yin and promoting granulation ruling by law.In treatment, the compound of clearing away heat and eliminating dampeness, nourishing yin and promoting granulation is constituted.Foundation《Interior warp》 " heat strongly fragrant and send out it ", the easily clear profit of damp evil, Yi Wenhua.
Oblongleaf Heterostemma：This product is dicotyledon medicine Asclepiadaceae Winged Heterostemma platymiscium Oblongleaf Heterostemma Hetrostemma The complete stool of oblongifolium Cost..Autumn harvests, and dries.【Nature and flavor】It is slight bitter, sweet；It is flat.【Return through】Liver Channel.【Function master Control】Lactagogue.Qi and blood stasis after main product；Agalactia.【Former phytomorph】Weak winding liana.Complete stool has milk, and stem is by 2 row Pubescence.Leaf opposite；Petiole 2-4cm long；Blade Long Circle, dilute ovate Long Circle, 7.5-11cm long, 3.5-4.5cm wide, tip is sharp Point, basal circular；Per side 5-7 bars, arc rises lateral vein.Umbrella shape shape cyme axillary, 2-3cm long is blossomed 4-5；Calyx 5 Drastic crack, inner face base portion has body of gland about 10；Corolla outside light green, inner face yellow, spoke shape, diameter 1-1.5cm；Corolla splits levies 5, Cover to the right；Paracorolla five-pointed star aristiform, the every room 1 of massula, square circular, uprightly.Follicle radish fruit wire lanceolar, is up to 12cm, diameter about 1cm, it is tapering to tip.Seed is up to 2cm, about 3mm wide, white thin,tough silk matter kind hair of the seed tool up to 3cm.Flower Month phase 8-10, the fruiting period 9-12 months.Record in dictionary of medicinal plant.
Katydid：This product is Tettigoniidae katydid category animal katydid Gampsaocleis gratiosa Brunner Wattenwyl. entirety.Summer, autumn catch, and catch rear boiling water and scald dead, dry or dry.【Nature and flavor】Taste is pungent；Micro-sweet；It is mild-natured.【Work( Can cure mainly】Inducing diuresis for removing edema；Remove obstruction in channels to relieve pain.Main oedema oliguria；Waist and knee swells and ache；Weak foot due to dampness.【Proterties】It is in Long Circle, ash that this product is all Green or yellowish-brown.Slightly rounded, 1 pair, the compound eye of head, oval, feeler 1 pair, length is whiplike, comes off more；Pronotary is slightly in elongated Cylinder, middle metathorax is by wing；Pereiopoda 3 pairs, comes off more, and metapedes is larger.Gas raw meat.Record in dictionary of medicinal plant.
Agrimonolide（Agrimonolide）：CAS 21499-24-1, molecular formula C18H18O5, molecular weight 314.34. 【Pharmacological action】The shrinkage amplitude and tension force of isolated rabbit intestines can be reduced, and bowel movement is stopped at relaxed state；Also can suppress The wriggling of body mouse intestines.【Purposes】Release smooth muscle spasm.【Ingredient origin】Rosaceous plant (Japan) Agrimony (hairyvein agrimony) Agrimonia pilosa Ledeb. var. japonica (MIq.) Nakai roots.
Nepeta glycosides（Nepetin-7-glucoside）：CAS 569-90-4, molecular formula C22H22O12, molecular weight 478.40.【Ingredient origin】Common Sage Herb Salvia plebeian..
2 bulk drug chemical constitutions：
Nepeta glycosides（Nepetin-7-glucoside）Agrimonolide（Agrimonolide）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition of effective treatment canker sore And preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition of the treatment canker sore be：
Oblongleaf Heterostemma 562-568 weight portion katydid 436-440 weight portion Nepeta glycosides 42-48 weight portion agrimonolides 32- 38 weight portions.
The pharmaceutical composition for the treatment of canker sore is preferably used in, is made up of the bulk drug of following weight portion：
The weight portion of 565 weight portion katydid of Oblongleaf Heterostemma, 438 46 weight portion agrimonolide of weight portion Nepeta glycosides 35.
A kind of pharmaceutical composition for treating canker sore, it is characterised in that pharmaceutical composition can be using the routine of galenic pharmacy Method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for treating canker sore, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine Treatment stomatocace medicine.
A kind of preparation method of the pharmaceutical composition for treating canker sore, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Oblongleaf Heterostemma 562-568 weight portion katydid 436-440 weight portion Nepeta glycosides 42-48 weight portion agrimonolide 32-38 weight portions；
Preparation method：
（1）Oblongleaf Heterostemma, katydid, Nepeta glycosides, agrimonolide are taken by bulk drug proportioning, is mixed, use weight percent concentration 36% ethanol takes as solvent in 25 DEG C of temperature extractions, and extraction time is 28 times, and each extraction time is 0.6 hour, each solvent Consumption is 12 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.11, filtration, liquid is first washed with water by FU-16 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 18% Liquid wash-out FU-16 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 18%, recovery ethanol, concentrate drying, Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 72% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.1 hour, each solvent load is 10 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.18 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 61.5% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol of weight percent concentration 61.5% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for treating canker sore, it is characterised in that make as follows It is standby：
The composition and weight portion of bulk drug be：The weight portion of 565 weight portion katydid of Oblongleaf Heterostemma, 438 weight portion Nepeta glycosides 46 The weight portion of agrimonolide 35；
Preparation method：
（1）Oblongleaf Heterostemma, katydid, Nepeta glycosides, agrimonolide are taken by bulk drug proportioning, is mixed, use weight percent concentration 36% ethanol takes as solvent in 25 DEG C of temperature extractions, and extraction time is 28 times, and each extraction time is 0.6 hour, each solvent Consumption is 12 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.11, filtration, liquid is first washed with water by FU-16 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 18% Liquid wash-out FU-16 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 18%, recovery ethanol, concentrate drying, Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 72% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.1 hour, each solvent load is 10 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.18 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 61.5% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol of weight percent concentration 61.5% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for treating canker sore, it is characterised in that pharmaceutical composition can be using system The conventional method of agent prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for treating canker sore, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine composition treatment stomatocace medicine.
Medicine composite for curing canker sore is evident in efficacy.
Specific embodiment
Embodiment 1：Treat pharmaceutical composition of canker sore and preparation method thereof
Treat canker sore pharmaceutical composition bulk drug composition and weight portion be：Oblongleaf Heterostemma 565g katydids 438g vacation chaste trees Mustard belongs to glycosides 46g agrimonolides 35g；
Preparation method：
（1）Oblongleaf Heterostemma, katydid, Nepeta glycosides, agrimonolide are taken by bulk drug proportioning, is mixed, use weight percent concentration 36% ethanol takes as solvent in 25 DEG C of temperature extractions, and extraction time is 28 times, and each extraction time is 0.6 hour, each solvent Consumption is 12 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.11, filtration, liquid is first washed with water by FU-16 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 18% Liquid wash-out FU-16 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 18%, recovery ethanol, concentrate drying, Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 72% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.1 hour, each solvent load is 10 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.18 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 61.5% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol of weight percent concentration 61.5% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Treat pharmaceutical composition of canker sore and preparation method thereof
Treat canker sore pharmaceutical composition bulk drug composition and weight portion be：Oblongleaf Heterostemma 562g katydids 440g vacation chaste trees Mustard belongs to glycosides 42g agrimonolides 38g；
Preparation method：
（1）Oblongleaf Heterostemma, katydid, Nepeta glycosides, agrimonolide are taken by bulk drug proportioning, is mixed, use weight percent concentration 36% ethanol takes as solvent in 25 DEG C of temperature extractions, and extraction time is 28 times, and each extraction time is 0.6 hour, each solvent Consumption is 12 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.11, filtration, liquid is first washed with water by FU-16 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 18% Liquid wash-out FU-16 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 18%, recovery ethanol, concentrate drying, Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 72% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.1 hour, each solvent load is 10 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.18 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 61.5% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol of weight percent concentration 61.5% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Treat pharmaceutical composition of canker sore and preparation method thereof
Treat canker sore pharmaceutical composition bulk drug composition and weight portion be：Oblongleaf Heterostemma 568g katydids 436g vacation chaste trees Mustard belongs to glycosides 48g agrimonolides 32g；
Preparation method：
（1）Oblongleaf Heterostemma, katydid, Nepeta glycosides, agrimonolide are taken by bulk drug proportioning, is mixed, use weight percent concentration 36% ethanol takes as solvent in 25 DEG C of temperature extractions, and extraction time is 28 times, and each extraction time is 0.6 hour, each solvent Consumption is 12 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.11, filtration, liquid is first washed with water by FU-16 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 18% Liquid wash-out FU-16 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 18%, recovery ethanol, concentrate drying, Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 72% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.1 hour, each solvent load is 10 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.18 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 61.5% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol of weight percent concentration 61.5% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 191g of Example 1, adds starch 210g, mixes, and granulation is dried, plus microcrystalline cellulose 70g, stearic Sour magnesium 8g, mixes, and is pressed into 1200, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 175g of Example 2, adds starch 243g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid Magnesium, mixes, and encapsulated 1150, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 234g water-baths and boil molten, add the pharmaceutical composition 11g of embodiment 3, fully stir Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is 2 DEG C, and drip internal-and external diameter is 7.0/ 1.5 (mm/mm), drip is 1.9cm away from liquid level, and drop speed is optimum condition with every point 53 drop, and the cold of dripping pill surface is blotted with cotton Solidifying agent, obtains final product medicament composition dropping pills.
Experimental example 1：The Experiment on Function research for the treatment of canker sore
1 clinical data
1.1 physical data
Include in June, -2011 in May, 2010 city's hospital outpatient patient 30, the course of disease 27 weeks~4.0 years.It is randomly divided into 2 groups. Treatment group 15, man 7, female 8；9~54 years old age, average (30.0 ± 12.0) year.Control group 15, man 8, female 7 Example；10~55 years old age, average (31.3 ± 11.5) year.2 groups of sexes, age, courses of disease are statistically analyzed, and difference is without aobvious Work property meaning (P ＞ 0.05), with comparativity.
1.2 diagnostic criteria
Reference《Oral medicine》With《Practical oral》Relevant criterion.
1. minor aphtha：Ulcer is small and shallow, number is few, 1~3,1~2mm, and redness does not write, and neat in edge has blush, base Bottom is slightly concave flat, heals within general 7~10 days, and heal preventing from scar.
2. stomatitis aphtha：Also known as herpetic aphtha, ulcer table is shallow flat, in irregular shape, can by small rice grain size to Broad bean size, number is more can be merged into each other up to dozens of, have yellow to ooze out, and surrounding is congested substantially, scope is big, and pain is obvious.
3. periglandular aphtha：Also known as huge aphtha, ulcer is big and shallow in cratering, ulcer area can beat more than 1cm, often It is isolated to occur, can also occur simultaneously several, edge is raised substantially, and hyperemia does not write or significantly red, and the course of disease is long, indolence, up to 1 The moon, to the several months, leaves scar after healing.
1.3 Standards of Chinese Medical Syndrome Differentiation
Reference《New Chinese medicine guideline of clinical investigations (tentative)》Relevant criterion, primary symptom：Canker sore, spontaneous pain, excitation is bitterly. Secondary disease：It is simultaneous to see the deficiency of both qi and yin performances such as the hot hidrosis of body, restlessness and thirst, scanty drak urine, the tired few gas of body, lassitude, deficient and rapid pulse.Body Inspection：Stomatocace contrafluxion oedema, skin surface oozes out pseudomembrane, and neat in edge substrate is flat, and ulcer is rounded or ellipse Circle, around have blush around.All to possess 3~5 persons in above primary symptom and secondary disease, i.e., dialectical is damp and hot long bridle, deficiency of both qi and yin Card type.
1.4 exclusion standards
1. Standards of Chinese Medical Syndrome Differentiation and Western medicine diagnostic criteria are not met, the non-damp and hot long bridle of TCM Syndrome Type, type of deficiency of both QI and YIN and doctor trained in Western medicine are examined It is non-RAU to break, such as traumatic ulcer, cancerous ulcer, infectious stomatitis, Behcet's disease and other ulcer persons.
2. purpose gestation or pregnant woman, women breast-feeding their children.
3. allergic constitution and to multi-medicament allergy sufferers.
4. serious disease or the mental patients such as angiocarpy, the cerebrovascular, liver, kidney diaseases and hemopoietic system are merged.
2 treatment methods
2.1 treatment groups
Treated using clearing away heat and eliminating dampeness, nourishing yin and promoting granulation method.Prescription：Pharmaceutical composition（The pharmaceutical composition lot number of embodiment 1 20090513）.Orally, each 1g, three times a day.
2.2 control groups
Using routine of western medicine drug therapy.Dexamethasone, each 0.75mg, three times a day, orally；ACV, every time 200 Mg, three times a day, orally；Levamisol, 50 mg every time, three times a day, orally.2 groups are treated 1 week for 1 course for the treatment of, treatment 2~4 The course for the treatment of.
3 evaluation indexes and statistical method
3.1 evaluation indexes
Reference《Recurrent aphthous ulcer therapeutic evaluation tentative standard》Relevant criterion, total intermittent time (interval, I), comments The valency period is without ulcer temporal summation；Total ulcer number (number, N), evaluates period ulcer recurrence number summation.I1：During total interval Between extension (t check, P ＜ 0.05)；I0：Total intermittent time is without change (t is checked, P ＜ 0.05)；The total ulcer numbers of N1 reduce (t inspections Test, P ＜ 0.05)；The total ulcer numbers of N0 are without change (t is checked, P ＜ 0.05).
3.2 statistical methods
Using SPSS11.5 for Windows statistical softwares, data are represented with (x ± s), are checked using t, enumeration data Using χ2Inspection.
4 criterions of therapeutical effect and treatment results
4.1 criterions of therapeutical effect
Recovery from illness：Canker sore terminates recurrence more than 1 year；
It is effective：I1N1；
Effectively：I1N0 or I0N1；
It is invalid：I0N0.
4.2 2 groups of Clinical efficacy comparisons
It is shown in Table 1.Treatment group's total effective rate 93.33%, control group total effective rate 66.67%.2 groups are compared, and difference has conspicuousness Meaning (P ＜ 0.05).
12 groups of Clinical efficacy comparisons example (%) of table
Group n Recovery from illness It is effective Effectively It is invalid Total effective rate (%)
Treatment group 15 6 7 1 1 93.33*
Control group 15 1 3 6 5 66.67
Compare with control group, * P<0.05.
N, I change are compared before and after 4.3 2 groups of treatments
It is shown in Table 2.N, I compare before and after 2 groups of treatments, and difference has significant (P ＜ 0.05).
N, I change are compared (x ± s) before and after 22 groups of treatments of table
Compare with before treatment, * P<0.05.

Claims (8)

1. a kind of pharmaceutical composition for treating canker sore, it is characterised in that be made the bulk drug of the pharmaceutical composition composition and Weight portion is：
Oblongleaf Heterostemma 562-568 weight portion katydid 436-440 weight portion Nepeta glycosides 42-48 weight portion agrimonolides 32- 38 weight portions.
2. a kind of pharmaceutical composition for treating canker sore according to claim 1, it is characterised in that be made the drug regimen The composition and weight portion of the bulk drug of thing be：
The weight portion of 565 weight portion katydid of Oblongleaf Heterostemma, 438 46 weight portion agrimonolide of weight portion Nepeta glycosides 35.
3. a kind of pharmaceutical composition for treating canker sore according to claim 1, it is characterised in that pharmaceutical composition can be with Piece agent or capsule or dripping pill are prepared using the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition for treating canker sore according to claim 1, it is characterised in that pharmaceutical composition with change Learn the treatment stomatocace medicine of medicine or Chinese medicine composition.
5. a kind of preparation method of the pharmaceutical composition for treating canker sore, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Oblongleaf Heterostemma 562-568 weight portion katydid 436-440 weight portion Nepeta glycosides 42-48 weight portion agrimonolide 32-38 weight portions；
Preparation method：
（1）Oblongleaf Heterostemma, katydid, Nepeta glycosides, agrimonolide are taken by bulk drug proportioning, is mixed, use weight percent concentration 36% ethanol takes as solvent in 25 DEG C of temperature extractions, and extraction time is 28 times, and each extraction time is 0.6 hour, each solvent Consumption is 12 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.11, filtration, liquid is first washed with water by FU-16 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 18% Liquid wash-out FU-16 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 18%, recovery ethanol, concentrate drying, Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 72% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.1 hour, each solvent load is 10 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.18 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 61.5% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol of weight percent concentration 61.5% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for treating canker sore according to claim 5, it is characterised in that by such as It is prepared by lower step：
The composition and weight portion of bulk drug be：The weight portion of 565 weight portion katydid of Oblongleaf Heterostemma, 438 weight portion Nepeta glycosides 46 The weight portion of agrimonolide 35；
Preparation method：
（1）Oblongleaf Heterostemma, katydid, Nepeta glycosides, agrimonolide are taken by bulk drug proportioning, is mixed, use weight percent concentration 36% ethanol takes as solvent in 25 DEG C of temperature extractions, and extraction time is 28 times, and each extraction time is 0.6 hour, each solvent Consumption is 12 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.11, filtration, liquid is first washed with water by FU-16 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 18% Liquid wash-out FU-16 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 18%, recovery ethanol, concentrate drying, Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 72% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.1 hour, each solvent load is 10 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.18 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 61.5% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol of weight percent concentration 61.5% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for treating canker sore according to claim 5, it is characterised in that medicine Composition can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition for treating canker sore according to claim 5, it is characterised in that medicine Composition and chemical drugs or Chinese medicine composition treatment stomatocace medicine.
CN201611133219.4A 2016-12-10 2016-12-10 A kind of pharmaceutical composition for treating canker sore Withdrawn CN106852948A (en)

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