CN106619771A - Medicine compositionc for preventing and treating hysteromyoma - Google Patents

Medicine compositionc for preventing and treating hysteromyoma Download PDF

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CN106619771A
CN106619771A CN201611132908.3A CN201611132908A CN106619771A CN 106619771 A CN106619771 A CN 106619771A CN 201611132908 A CN201611132908 A CN 201611132908A CN 106619771 A CN106619771 A CN 106619771A
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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Abstract

The invention discloses a medicine compositionc for preventing and treating hysteromyoma and a preparation method thereof. The medicine compositionc disclosed by the invention is prepared from the following crude drugs at a certain ratio: loxogramme chinensis, pogonatum aloides, thyrocarpus sampsonii, eupatilin, acrifoline and tormentic acid. The medicine compositionc can be prepared into various preparations according to a conventional preparation process and is effective in preventing and treating hysteromyoma.

Description

A kind of pharmaceutical composition of preventing and treating hysteromyoma
Technical field
The invention belongs to technical field of Chinese medicines, more particularly to a kind of pharmaceutical composition and its preparation side of preventing and treating hysteromyoma Method.
Background technology
Hysteromyoma is one of common benign tumor of gynecological, and doctor trained in Western medicine thinks may be relevant with long-term estrogen stimulation, often With gonadotherapy, of short duration improvement is can only obtain, muscular tumor grows faster after drug withdrawal.Traditional Chinese medical science viewpoint thinks, hysteromyoma equivalent to The scope of " stony mass of uterus ", such as《Ling Shu Miraculous Pivot or Divine Axis. a watery distension piece》Middle theory " stony mass of uterus is born in born of the same parents, cold visitor in door, cervical orifice of uterus is inaccessible, and gas must not lead to, Whether when or not ， bloody stasis are rushed down, to stay only, day is big with benefit, and shape such as cherishes son, irregular menstrual cycle for stagnant blood ".《Plain Questions. bone empty talk》Middle theory:" conception vessel To tie seven kinds of hernia in disease, man, woman's leukorrhagia abdominal mass is gathered ".《All source of disease marquis opinions. the miscellaneous internal diseases in woman nobility two》Middle theory:" eight abdominal mass persons, all born of the same parents Viviparity is produced, and moon water contact, the uncomfortable institute of blood vessels vital essence is raw." add:" gynecopathy's is beneficial to husband person, or because puerperal it is dirty Void is caught cold, or because of the contact of Jing water, take it is cold excessively, non-only pass intemperance of taking food, more come have vim and vigour institute into.”《All source of disease marquis opinions. woman People's miscellaneous diseases nobility two》Middle theory:", by eating and drinking without temperance, cold-damp is uncomfortable for Fu Ren mass in the abdomen, QI and blood impairment caused by overstrain, and internal organs are weak, it is air-cooled enter abdomen with Blood is mutually tied and given birth to." hysteromyoma is one of common benign tumor of gynecological, age of onset is more 30～50 years old.Adopting doctor trained in Western medicine more The medicines such as progestogen, mifepristone and some promoting sexual gland hormone.Muscular tumor belongs to hormone-dependent tumor, has to using hormone drug Of short duration improvement, muscular tumor can grow faster after drug withdrawal.Operative treatment can increase the financial burden of patient and increase it is unnecessary after Lose disease.
Loxogramme chinensis ching.：This product is the root of Loxogrammaceae sword Cyclosorus plant Loxogramme chinensis ching. Loxogramme chinensis Ching Stem or herb.Whole year can harvest rhizome, the 7-9 months harvest herb, dry.【Nature and flavor】It is bitter；Cold nature.【Return through】Bladder；Kidney Jing.【Indication】Heat-clearing and toxic substances removing；Diuresis.Main urinary tract infection；Mastitis；Lyssodexiss.【Former phytomorph】The high 8- of plant 18cm.Rhizome is elongated, grows wild, close by brown brown, lanceolar scale.Ye Jinsheng, has short handle；Blade meat, wire lanceolar is long 5-17cm, middle part width 1-1.2cm, the sharp point of tip, base portion wedge shape and under be extended down to petiole bottom, full edge or wavy, do after remove from office Matter, there is above wrinkle；Slightly swell on middle arteries two sides.Sporangioruses Long Circle, is separated from each other by usual 5-8 pair, pole obliquely, sometimes It is several with middle arteries parallel, middle arteries both sides are arranged in, it is grown on more than back side middle part, bottom infertility；Without indusium.Record big in Chinese medicine Dictionary.
Little pigeon-wheat：For pigeon-wheat section Pogonatum plant Pogonatum inflexum (Lindb.) Lac. Pogonatum inflexum （Lindb.) the herb of Lac. ［ Polytricum inflexum Lindb. ］.The 5-7 months harvest, and clean, and dry.【Nature and flavor】It is pungent； Temperature.【Indication】Tranquillizing and allaying excitement；Dissipating blood stasis；Hemostasis.Main severe palpitation；Insomnia and dreamful sleep；Traumatic injury；Spit blood.【Chemical analysis】 Containing taurine.【Character】This product is the several plants of agglomerates gathered together together, stem length 2-8cm, dirty-green or yellowish-brown.Moistening is separated Afterwards, every plant of stem is single, the thin rhizoid of the close life of base portion.The wealthy lanceolar of leaf, tapering, base portion avette, the indent of circle, demisheath shape, edge has slightly Sawtooth；Middle rib is thick, and up to blade tip, the outside of belly is covered with comb piece.Some visible elongate setas, it is orange-yellow.Sporangium cylinder, opercule has length Beak, yellow of capsule cap gathering becomes mildewed.Feeble QI, it is lightly seasoned.Record in dictionary of medicinal plant.
Radix Thyrocarpi sampsonii：The herb of Boraginaceae Radix Thyrocarpi sampsonii platymiscium Radix Thyrocarpi sampsonii Thyrocarpus sampsonii Hance.4～6 The moon adopts herb, dries.【Nature and flavor】It is bitter；It is cool.【Return through】The heart；Large intestine channel.【Indication】Clearing heat, releasing toxin, removing swelling.Main carbuncle；Furuncle Skin ulcer；Have sore throat；Have loose bowels；Dysentery.【Character】Stem is thinner, and 1 to several, cylinder, long 10-30cm, the withered green in surface has greyish white Color rough hair, the crisp frangibility of matter, section white.Basal leaf is grown thickly, shrinkage curling, and after moistening is launched, cochlear has handle, long 3.5- 19cm, wide 1-5cm, withered green or bottle green, two sides has canescence coarse wool, and stem leaf is less, stockless.Blade is slightly thick.Sometimes It can be seen that blue or purple little Hua.Or having the pyrene of the bowl-shape projection of two-layer, base top exterior layer has upright gear, and internal layer is close to side Edge.Feeble QI mildly bitter flavor.Record in dictionary of medicinal plant.
Eupatilin（Eupatilin）：CAS 22368-21-4, molecular formula C18H16O7, molecular weight 344.31.【It is biological Activity】Cell toxicant (KB, ED50=38 or 45 μ g/ml).【Ingredient origin】Half zigzag Herba Lycopi Eupatorium Semiserratum, red sufficient Artemisia Artemisia rubripes, Pericarpium Citri tangerinae Citrus reticulata.
Acrifoline（Acrifoline）：CAS 664-24-4, molecular formula C16H23NO2, molecular weight 261.36.【Composition Source】Herba Lycopodii Selaginiies Huperzia selago [Syn. Lycopodium selago], 2 years Lycopodium clavatum Lycopodium annotinum var. acrifolium。
Termentic acid（Tormentic acid）：CAS 13850-16-3, molecular formula C30H48O5, molecular weight 488.71. 【Biological activity】Antibacterial（Streptococcus mutation）；Blood sugar lowering（Rat orl, 10mg/kg）.【Ingredient origin】Herba Elsholtziae Ciliatae Elsholtzia ciliata, Folium Eriobotryae Eriobotrya japonica, Fructus Adinae Geum japonicum, buttockss shape fruit Pygeum topengii, Xinjiang-Tibet vacation Radix Arnebiae (Radix Lithospermi) Arnebia euchroma, Herba Lycopi Lycopus lucidus.
The chemical constitution of 3 crude drug：
Acrifoline（Acrifoline）
Eupatilin（Eupatilin）Termentic acid（Tormentic acid）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition of effective preventing and treating hysteromyoma And preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for making the crude drug of the pharmaceutical composition of the preventing and treating hysteromyoma be：
The different Herba Lycopi of the little pigeon-wheat 750-758 weight portion Radix Thyrocarpi sampsonii 740-750 weight portions of Loxogramme chinensis ching. 800-810 weight portions is yellow Plain 65-70 weight portions acrifoline 30-40 weight portion termentic acid 20-24 weight portions.
The pharmaceutical composition of preventing and treating hysteromyoma is preferably used in, is made up of the crude drug of following weight portion：
The weight portion of 745 weight portion eupatilin of the little 754 weight portion Radix Thyrocarpi sampsonii of pigeon-wheat of the weight portion of Loxogramme chinensis ching. 805 68 point The weight portion of 35 weight portion termentic acid of leaf lycopodine 22.
A kind of pharmaceutical composition of preventing and treating hysteromyoma, it is characterised in that pharmaceutical composition can adopt the routine of galenic pharmacy Method prepares piece agent or capsule or drop pill.
A kind of pharmaceutical composition of preventing and treating hysteromyoma, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine Preventing and treating hysteromyoma medicine.
A kind of preparation method of the pharmaceutical composition of preventing and treating hysteromyoma, it is characterised in that prepare as follows：
The composition and weight portion of crude drug be：The little pigeon-wheat 750-758 weight portion Radix Thyrocarpi sampsonii of Loxogramme chinensis ching. 800-810 weight portions 740-750 weight portion eupatilin 65-70 weight portion acrifoline 30-40 weight portion termentic acid 20-24 weight Part；
Preparation method：
（1）Little pigeon-wheat, Radix Thyrocarpi sampsonii, Loxogramme chinensis ching., eupatilin, acrifoline, termentic acid are taken by crude drug proportioning, Mix, with the ethanol of weight percent concentration 37% as solvent, extract in 37.5 DEG C of warm macerating, extraction time is 36 times, is extracted every time Time is 19 hours, and each solvent load is 45 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A is returned Ethanol is received, relative density 1.07 is concentrated into, is filtered, medicinal liquid is first washed with water by X-5 macroporous adsorptive resins, then uses weight The ethanol solution eluting X-5 macroporous adsorptive resins of percent concentration 24%, collect the ethanol elution of weight percent concentration 24%, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 57% as solvent, heating and refluxing extraction 8 times, carries every time The time is taken for 0.3 hour, each solvent load is 52 times of medicinal residues A weight, filtration obtains medicinal residues B and extracting solution B, and extracting solution B is reclaimed Ethanol, is concentrated into relative density 1.16, and filtration, medicinal liquid is first washed with water by HC-ADS-8 macroporous adsorptive resins, then with again The amount ethanol solution eluting HC-ADS-8 macroporous adsorptive resins of percent concentration 73%, collect the ethanol of weight percent concentration 73% and wash De- liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
The preparation method of the pharmaceutical composition of preferred a kind of preventing and treating hysteromyoma, it is characterised in that make as follows It is standby：
The composition and weight portion of crude drug be：The little weight of 754 weight portion Radix Thyrocarpi sampsonii of pigeon-wheat 745 of the weight portion of Loxogramme chinensis ching. 805 The weight portion of 35 weight portion termentic acid of part 68 weight portion acrifoline of eupatilin 22；
Preparation method：
（1）Little pigeon-wheat, Radix Thyrocarpi sampsonii, Loxogramme chinensis ching., eupatilin, acrifoline, termentic acid are taken by crude drug proportioning, Mix, with the ethanol of weight percent concentration 37% as solvent, extract in 37.5 DEG C of warm macerating, extraction time is 36 times, is extracted every time Time is 19 hours, and each solvent load is 45 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A is returned Ethanol is received, relative density 1.07 is concentrated into, is filtered, medicinal liquid is first washed with water by X-5 macroporous adsorptive resins, then uses weight The ethanol solution eluting X-5 macroporous adsorptive resins of percent concentration 24%, collect the ethanol elution of weight percent concentration 24%, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 57% as solvent, heating and refluxing extraction 8 times, carries every time The time is taken for 0.3 hour, each solvent load is 52 times of medicinal residues A weight, filtration obtains medicinal residues B and extracting solution B, and extracting solution B is reclaimed Ethanol, is concentrated into relative density 1.16, and filtration, medicinal liquid is first washed with water by HC-ADS-8 macroporous adsorptive resins, then with again The amount ethanol solution eluting HC-ADS-8 macroporous adsorptive resins of percent concentration 73%, collect the ethanol of weight percent concentration 73% and wash De- liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition of preventing and treating hysteromyoma, it is characterised in that pharmaceutical composition can be using system The conventional method of agent prepares piece agent or capsule or drop pill.
A kind of preparation method of the pharmaceutical composition of preventing and treating hysteromyoma, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine composition preventing and treating hysteromyoma medicine.
Pharmaceutical composition preventing and treating hysteromyoma effect is notable.
Specific embodiment
Embodiment 1：Pharmaceutical composition of preventing and treating hysteromyoma and preparation method thereof
Preventing and treating hysteromyoma pharmaceutical composition crude drug composition and weight portion be：The little pigeon-wheat of Loxogramme chinensis ching. 805g 754g Radix Thyrocarpi sampsonii 745g eupatilin 68g acrifoline 35g termentic acid 22g；
Preparation method：
（1）Little pigeon-wheat, Radix Thyrocarpi sampsonii, Loxogramme chinensis ching., eupatilin, acrifoline, termentic acid are taken by crude drug proportioning, Mix, with the ethanol of weight percent concentration 37% as solvent, extract in 37.5 DEG C of warm macerating, extraction time is 36 times, is extracted every time Time is 19 hours, and each solvent load is 45 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A is returned Ethanol is received, relative density 1.07 is concentrated into, is filtered, medicinal liquid is first washed with water by X-5 macroporous adsorptive resins, then uses weight The ethanol solution eluting X-5 macroporous adsorptive resins of percent concentration 24%, collect the ethanol elution of weight percent concentration 24%, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 57% as solvent, heating and refluxing extraction 8 times, carries every time The time is taken for 0.3 hour, each solvent load is 52 times of medicinal residues A weight, filtration obtains medicinal residues B and extracting solution B, and extracting solution B is reclaimed Ethanol, is concentrated into relative density 1.16, and filtration, medicinal liquid is first washed with water by HC-ADS-8 macroporous adsorptive resins, then with again The amount ethanol solution eluting HC-ADS-8 macroporous adsorptive resins of percent concentration 73%, collect the ethanol of weight percent concentration 73% and wash De- liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Pharmaceutical composition of preventing and treating hysteromyoma and preparation method thereof
Preventing and treating hysteromyoma pharmaceutical composition crude drug composition and weight portion be：The little pigeon-wheat of Loxogramme chinensis ching. 800g 758g Radix Thyrocarpi sampsonii 740g eupatilin 70g acrifoline 30g termentic acid 24g；
Preparation method：
（1）Little pigeon-wheat, Radix Thyrocarpi sampsonii, Loxogramme chinensis ching., eupatilin, acrifoline, termentic acid are taken by crude drug proportioning, Mix, with the ethanol of weight percent concentration 37% as solvent, extract in 37.5 DEG C of warm macerating, extraction time is 36 times, is extracted every time Time is 19 hours, and each solvent load is 45 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A is returned Ethanol is received, relative density 1.07 is concentrated into, is filtered, medicinal liquid is first washed with water by X-5 macroporous adsorptive resins, then uses weight The ethanol solution eluting X-5 macroporous adsorptive resins of percent concentration 24%, collect the ethanol elution of weight percent concentration 24%, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 57% as solvent, heating and refluxing extraction 8 times, carries every time The time is taken for 0.3 hour, each solvent load is 52 times of medicinal residues A weight, filtration obtains medicinal residues B and extracting solution B, and extracting solution B is reclaimed Ethanol, is concentrated into relative density 1.16, and filtration, medicinal liquid is first washed with water by HC-ADS-8 macroporous adsorptive resins, then with again The amount ethanol solution eluting HC-ADS-8 macroporous adsorptive resins of percent concentration 73%, collect the ethanol of weight percent concentration 73% and wash De- liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Pharmaceutical composition of preventing and treating hysteromyoma and preparation method thereof
Preventing and treating hysteromyoma pharmaceutical composition crude drug composition and weight portion be：The little pigeon-wheat of Loxogramme chinensis ching. 810g 750g Radix Thyrocarpi sampsonii 750g eupatilin 65g acrifoline 40g termentic acid 20g；
Preparation method：
（1）Little pigeon-wheat, Radix Thyrocarpi sampsonii, Loxogramme chinensis ching., eupatilin, acrifoline, termentic acid are taken by crude drug proportioning, Mix, with the ethanol of weight percent concentration 37% as solvent, extract in 37.5 DEG C of warm macerating, extraction time is 36 times, is extracted every time Time is 19 hours, and each solvent load is 45 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A is returned Ethanol is received, relative density 1.07 is concentrated into, is filtered, medicinal liquid is first washed with water by X-5 macroporous adsorptive resins, then uses weight The ethanol solution eluting X-5 macroporous adsorptive resins of percent concentration 24%, collect the ethanol elution of weight percent concentration 24%, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 57% as solvent, heating and refluxing extraction 8 times, carries every time The time is taken for 0.3 hour, each solvent load is 52 times of medicinal residues A weight, filtration obtains medicinal residues B and extracting solution B, and extracting solution B is reclaimed Ethanol, is concentrated into relative density 1.16, and filtration, medicinal liquid is first washed with water by HC-ADS-8 macroporous adsorptive resins, then with again The amount ethanol solution eluting HC-ADS-8 macroporous adsorptive resins of percent concentration 73%, collect the ethanol of weight percent concentration 73% and wash De- liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 235g of Example 1, adds starch 348g, mixes, and granulation is dried, plus Microcrystalline Cellulose 220g, Hard Fat Sour magnesium 7g, mixes, and is pressed into 2600, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 170g of Example 2, adds starch 168g, mixes, and granulation is dried, granulate, adds appropriate stearic acid Magnesium, mixes, and encapsulated 800, obtains final product medicament composition capsule.
Embodiment 6：The preparation of drop pill
Weigh (80 DEG C) heating of polyethylene glycol 6000 278g water-baths and boil molten, add the pharmaceutical composition 14g of embodiment 3, fully stir Mix uniform, with liquid paraffin as coolant, put glass tubing（4*80cm）In, chilling temperature is 5 DEG C, and drip internal-and external diameter is 7.0/ 2.0 (mm/mm), drip is 2.6cm away from liquid level, and drop speed, as optimum condition, with cotton the cold of drop pill surface is blotted with per point 65 drops Solidifying agent, obtains final product medicament composition dropping pills.
Experimental example 1：The experimental study of preventing and treating hysteromyoma
1. data and method
This group of patient 33,30～51 years old age, wherein 30～35 years old 4.The course of disease 2 months～5 years, wherein intramural myoma 27 Example, Subserous myoma 4, muscular tumor 2 under mucosa.
2. Therapeutic Method
Oral medicament composition therapeutic rules:Heat clearing and damp drying, blood-nourishing and blood, Chong and Ren Meridians regulating.Square medicine:The drug regimen of embodiment 1 3g.Add and subtract with disease:The obvious person of the deficiency of YIN is with Radix Scrophulariae, Radix Ophiopogonis, Herba Ecliptae；The obvious person of cold-damp adds Radix Bupleuri, chaste tree buckwheat fringe；The obvious person of kidney deficiency Plus Radix Dipsaci, Semen Cuscutae, Radix Rehmanniae Preparata, Semen Nelumbiniss；Heat in blood is heavier, bleeding is more, irregular menses removes Radix Angelicae Sinensis, Rhizoma Chuanxiong, plus Cortex Lycii, Herba Artemisiae Annuae, Chinese toon root white skin, Os Sepiae, Concha Ostreae；Haemophilia adds Cacumen Platycladi preparata, charred Petiolus Trachycarpi, GUANZHONGTAN, Colla Corii Asini block；Dizzy, headache, liver-yang hyperactivity Substantially person adds Folium Mori, Flos Chrysanthemi, Fructus Ligustri Lucidi, Herba Ecliptae, Dens Draconis, Concha Margaritifera；Insufficiency of the spleen obvious person add Radix Pseudostellariae, Rhizoma Dioscoreae, Semen Nelumbinis, The Rhizoma Atractylodis Macrocephalae；Damp invasion of lower energizer is with Herba Dianthi, Semen Plantaginiss, Caulis Akebiae；Stagnation of QI pain substantially adds Fructus Toosendan, Rhizoma Corydalis, Oletum Trogopterori, Rhizoma Cyperi.
3. curative effect judging standard
Follow-up 2 years, according to the super inspection hysteromyoma developments of B and clinical symptoms situation is improved.
1. it is effective:Muscular tumor reduces, clinical symptom disappearance；
2. it is effective:Muscular tumor does not develop, clinical symptom relief；
3. it is invalid:Muscular tumor continues to increase, and clinical symptoms are unchanged.
4. result
33 patients, the course for the treatment of 7 days～6 months is taken medicine 7～35 doses, and generally speaking, anomalous uterine is obtained substantially To control, clinical symptoms make moderate progress.The super inspection results of B, 19 patients with uterin leiomyoma have no development, and 13 muscular tumors reduce, 1 Muscular tumor has increase.15 are recovered normal wherein in menorrhagia 19, and 4 Jing amounts are reduced earlier above.Pass through in the passing of time 16 8 are recovered normal, and 8 routine Jing times shortened.Eumenorrhea, there is menstrual period waist abdominal distention and pain 4, symptom substantially mitigates.1 routine Jing With the passing of time fail to improve and finally take operative treatment.The treatment of the patients with uterin leiomyoma of summary 33,13 are effective, and 19 are effectively, 1 invalid, total effective rate 96.97%.
Case 1:Patient, female, 45 years old, June 15 2012 first visit date.Vagina irregularly goes out over patient is nearly 2 years There is two weeks vaginal hemorrhage in blood, 1 middle of the month.June 13 in 2013, Nikkei Jiyang gynecological of county people's hospital went to a doctor, and B is super to be checked: Uterus size 10cm × 8cm × 6cm, the muscular tumor of the visible 5cm × 2.8cm sizes of endometrium.Pathologic study of endometrium: Cystic hyperplasia of endometrium.Tentative diagnosis is mucosa hysteromyoma, it is desirable to operative treatment, and patient is because of economic condition and body feelings Condition is not agreed to.Examine on July 16th, 2013, many more than 10 days of main suit's colporrhagia amount, malaise, xerostomia, feverish sensation in the palms and soles Breast gastral cavity is stuffy.In last menstrual period on June 28th, 2013, gynecologial examination is not done, B is super to check the same.Blood series report:Leukocyte 9.1×109/ L, neutrophilic granulocyte 76%, lymphocyte 23%, mononuclear cell 1.0%.Body of the tongue is light red, and yellow fur is done, stringy and rolling pulse number.West Doctor's diagnosis:Mucosa hysteromyoma.Tcm diagnosis:Heat in blood is wet to accumulate, Chong and Ren channel disorder.Method for the treatment of:Heat clearing and damp drying, removing heat from blood Gu Chong.Side Medicine:The drug regimen 3g of embodiment 1.Orally, each 1g, 3 times a day.After serveing on 15 days, B is super to be checked, uterus size 10cm × 6cm × 6cm, the muscular tumor of the visible 4cm × 2.5cm sizes of endometrium, follow-up in 2 years later, menstruation is normal always, muscular tumor Do not develop.

Claims (8)

1. it is a kind of preventing and treating hysteromyoma pharmaceutical composition, it is characterised in that make the pharmaceutical composition crude drug composition and Weight portion is：
The different Herba Lycopi of the little pigeon-wheat 750-758 weight portion Radix Thyrocarpi sampsonii 740-750 weight portions of Loxogramme chinensis ching. 800-810 weight portions is yellow Plain 65-70 weight portions acrifoline 30-40 weight portion termentic acid 20-24 weight portions.
2. according to claim 1 it is a kind of preventing and treating hysteromyoma pharmaceutical composition, it is characterised in that make the drug regimen The composition and weight portion of the crude drug of thing be：
The weight portion of 745 weight portion eupatilin of the little 754 weight portion Radix Thyrocarpi sampsonii of pigeon-wheat of the weight portion of Loxogramme chinensis ching. 805 68 point The weight portion of 35 weight portion termentic acid of leaf lycopodine 22.
3. a kind of pharmaceutical composition of preventing and treating hysteromyoma according to claim 1, it is characterised in that pharmaceutical composition can be with Piece agent or capsule or drop pill are prepared using the conventional method of galenic pharmacy.
4. according to claim 1 it is a kind of preventing and treating hysteromyoma pharmaceutical composition, it is characterised in that pharmaceutical composition with change Learn the preventing and treating hysteromyoma medicine of medicine or Chinese medicine composition.
5. it is a kind of preventing and treating hysteromyoma pharmaceutical composition preparation method, it is characterised in that prepare as follows：
The different Herba Lycopi of the little pigeon-wheat 750-758 weight portion Radix Thyrocarpi sampsonii 740-750 weight portions of Loxogramme chinensis ching. 800-810 weight portions is yellow Plain 65-70 weight portions acrifoline 30-40 weight portion termentic acid 20-24 weight portions；
Preparation method：
（1）Little pigeon-wheat, Radix Thyrocarpi sampsonii, Loxogramme chinensis ching., eupatilin, acrifoline, termentic acid are taken by crude drug proportioning, Mix, with the ethanol of weight percent concentration 37% as solvent, extract in 37.5 DEG C of warm macerating, extraction time is 36 times, is extracted every time Time is 19 hours, and each solvent load is 45 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A is returned Ethanol is received, relative density 1.07 is concentrated into, is filtered, medicinal liquid is first washed with water by X-5 macroporous adsorptive resins, then uses weight The ethanol solution eluting X-5 macroporous adsorptive resins of percent concentration 24%, collect the ethanol elution of weight percent concentration 24%, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 57% as solvent, heating and refluxing extraction 8 times, carries every time The time is taken for 0.3 hour, each solvent load is 52 times of medicinal residues A weight, filtration obtains medicinal residues B and extracting solution B, and extracting solution B is reclaimed Ethanol, is concentrated into relative density 1.16, and filtration, medicinal liquid is first washed with water by HC-ADS-8 macroporous adsorptive resins, then with again The amount ethanol solution eluting HC-ADS-8 macroporous adsorptive resins of percent concentration 73%, collect the ethanol of weight percent concentration 73% and wash De- liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. according to claim 5 it is a kind of preventing and treating hysteromyoma pharmaceutical composition preparation method, it is characterised in that by such as It is prepared by lower step：
The weight portion of 745 weight portion eupatilin of the little 754 weight portion Radix Thyrocarpi sampsonii of pigeon-wheat of the weight portion of Loxogramme chinensis ching. 805 68 point The weight portion of 35 weight portion termentic acid of leaf lycopodine 22；
Preparation method：
（1）Little pigeon-wheat, Radix Thyrocarpi sampsonii, Loxogramme chinensis ching., eupatilin, acrifoline, termentic acid are taken by crude drug proportioning, Mix, with the ethanol of weight percent concentration 37% as solvent, extract in 37.5 DEG C of warm macerating, extraction time is 36 times, is extracted every time Time is 19 hours, and each solvent load is 45 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A is returned Ethanol is received, relative density 1.07 is concentrated into, is filtered, medicinal liquid is first washed with water by X-5 macroporous adsorptive resins, then uses weight The ethanol solution eluting X-5 macroporous adsorptive resins of percent concentration 24%, collect the ethanol elution of weight percent concentration 24%, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 57% as solvent, heating and refluxing extraction 8 times, carries every time The time is taken for 0.3 hour, each solvent load is 52 times of medicinal residues A weight, filtration obtains medicinal residues B and extracting solution B, and extracting solution B is reclaimed Ethanol, is concentrated into relative density 1.16, and filtration, medicinal liquid is first washed with water by HC-ADS-8 macroporous adsorptive resins, then with again The amount ethanol solution eluting HC-ADS-8 macroporous adsorptive resins of percent concentration 73%, collect the ethanol of weight percent concentration 73% and wash De- liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. according to claim 5 it is a kind of preventing and treating hysteromyoma pharmaceutical composition preparation method, it is characterised in that medicine Compositionss can adopt the conventional method of galenic pharmacy to prepare piece agent or capsule or drop pill.
8. according to claim 5 it is a kind of preventing and treating hysteromyoma pharmaceutical composition preparation method, it is characterised in that medicine Compositionss and chemical drugs or Chinese medicine composition preventing and treating hysteromyoma medicine.
CN201611132908.3A 2016-12-10 2016-12-10 Medicine compositionc for preventing and treating hysteromyoma Withdrawn CN106619771A (en)

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