CN106177396A - A kind of Chinese medicine external compound preparation treating threatened abortion and preparation method - Google Patents
A kind of Chinese medicine external compound preparation treating threatened abortion and preparation method Download PDFInfo
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- CN106177396A CN106177396A CN201610647738.6A CN201610647738A CN106177396A CN 106177396 A CN106177396 A CN 106177396A CN 201610647738 A CN201610647738 A CN 201610647738A CN 106177396 A CN106177396 A CN 106177396A
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Abstract
The invention discloses a kind of Chinese medicine external compound preparation treating threatened abortion and preparation method, including Radix Codonopsis, Radix Angelicae Sinensis, Radix Scutellariae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Caulis Perillae, Rhizoma Cyperi, the Cortex Eucommiae, Radix Dipsaci, Bulbus Fritillariae Thunbergii, Radix Rehmanniae Preparata, sodium benzoate, Mel, the preparation method of a kind of Chinese medicine external compound preparation treating threatened abortion is disclosed simultaneously.Medicine of the present invention is directly permeated by local skin and is absorbed, conduct through meridian point simultaneously, medicine is made to play its integrally-regulated effect, can significantly shorten threatened abortion patient's vaginal bleeding time and stomachache, soreness of waist transference cure time, especially there is significant advantage to improving soreness of waist symptom, clinical effective rate reaches more than 99%, and preventing miscarriage with Western medicine to share to significantly improve success rate of preventing miscarriage；External application for curing threatened abortion of the present invention, without obvious toxic-side effects, safety, easy, economical, patient acceptance is high, and curative effect certainly, highlights characteristic and the advantage of Chinese medicine.
Description
Technical field
The invention belongs to pharmaceutical technology field, particularly relate to a kind of Chinese medicine external compound preparation treating threatened abortion and system
Preparation Method.
Background technology
Threatened abortion (tcm diagnosis: vaginal bleeding during pregnancy, frequent fetal movement) refers to that the vagina occurred during gestation is the most hemorrhage, at present
Time only, with slight lower abdominal pain and a kind of disease of the soreness of waist, gestation can be continued after treatment timely, appropriate.Threatened abortion
Being to affect women's health, the important diseases of family social harmony, the soreness of waist is one of cardinal symptom of threatened abortion.Chinese medicine is recognized
For, kidney governing reproduction, is born of the same parents' tires, suffering from a deficiency of the kidney of the many duties of threatened abortion, and waist is mansion outside kidney, and person who suffer from deficiency of kidney Yang waist is become homeless foster, therefore seen the soreness of waist.If
Do not paid attention to and treated in time, inevitable abortion (tcm diagnosis: induced abortion, abortion) may be developed into.
Western medicine treatment threatened abortion, many employing progestogen intramuscular injection, there is injection site local response weight, patient couple
The difficult problems such as hormone acceptance difference, and lack effective ways to improving threatened abortion patient's soreness of waist symptom.The traditional Chinese medical science is started with from kidney, passes through
The oral antiabortive Chinese medicine of replenishing kidney, strengthening waist, can improve the threatened abortion symptoms such as patient vaginal hemorrhage, stomachache and the soreness of waist, improves and prevents miscarriage into
Power, but there is the problems such as decoction is loaded down with trivial details, patient compliance is poor.Clinic need badly treatment the economy of threatened abortion, simplicity, effectively outside
By preparation and method.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine external compound preparation treating threatened abortion and preparation method, it is intended to
Solve in treatment threatened abortion that current Chinese medicine decoction is loaded down with trivial details, patient compliance is poor, clinic does not also have economy, simplicity, effectively
The problem of external preparation.
The present invention is achieved in that a kind of Chinese medicine external compound preparation treating threatened abortion, this treatment threatened abortion
Chinese medicine external compound preparation by weight component be: Radix Codonopsis 30-80g, Radix Angelicae Sinensis 30-80g, Radix Scutellariae 25-75g, Radix Paeoniae Alba 5-30g,
Rhizoma Chuanxiong 5-30g, Rhizoma Atractylodis Macrocephalae 30-80g, Pericarpium Citri Reticulatae 5-30g, Caulis Perillae 5-30g, Rhizoma Cyperi 5-30g, Cortex Eucommiae 5-30g Radix Dipsaci 5-30g, Bulbus Fritillariae Thunbergii 5-
30g, Radix Rehmanniae Preparata 50-120g, sodium benzoate 2-10g, Mel 200-600g.
Another object of the present invention is to provide the preparation method of a kind of Chinese medicine external compound preparation treating threatened abortion,
The preparation method of the Chinese medicine external compound preparation of this treatment threatened abortion comprises the following steps:
Take Radix Rehmanniae Preparata, Radix Codonopsis is soaked, and after being heated to boiling, little fire decocts, and filters medicinal residues, the medicine after boiling filtration
Slag, filters, merging filtrate, is stirred continuously and is concentrated into paste, prepares concentrated solution；
Take Radix Angelicae Sinensis, Radix Scutellariae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Caulis Perillae, Rhizoma Cyperi, the Cortex Eucommiae, Radix Dipsaci, Bulbus Fritillariae Thunbergii are all dried, powder
Broken sieve, be mixed into scattered, add sodium benzoate after mixing with Radix Rehmanniae Preparata, Radix Codonopsis concentrated solution, stir；
Taking Mel appropriate, be heated to boiling, filter, addition concentrated solution is with scattered mixture by several times, mixes all.
Further, the preparation method of the Chinese medicine external compound preparation for the treatment of threatened abortion concretely comprises the following steps:
Take Radix Rehmanniae Preparata, Radix Codonopsis adds water 800ml (Radix Rehmanniae Preparata, Radix Codonopsis than water with the part by weight of 1:5) soaks 30～40 minutes, heating
To boiling, little fire decocts 40～50 minutes, filters medicinal residues, boiling 25～35 minutes, filters, merging filtrate, be stirred continuously
It is concentrated into paste, hangs preferably flag with stirring rod；
Remainder medicine is dried, and pulverized 100 mesh sieves, and was mixed into scattered, adds sodium benzoate 5g, stirs；
Taking Mel appropriate, be heated to boiling, filter, addition concentrated solution is with scattered mixture by several times, mixes all.
Further, each component weighed in the preparation of the Chinese medicine external compound preparation for the treatment of threatened abortion is by weight:
Radix Codonopsis 30-80g Radix Angelicae Sinensis 30-80g Radix Scutellariae 25-75g Radix Paeoniae Alba 5-30g Rhizoma Chuanxiong 5-30g Rhizoma Atractylodis Macrocephalae 30-80g Pericarpium Citri Reticulatae 5-30g Caulis Perillae 5-30g
Rhizoma Cyperi 5-30g Cortex Eucommiae 5-30g Radix Dipsaci 5-30g Bulbus Fritillariae Thunbergii 5-30g Radix Rehmanniae Preparata 50-120g sodium benzoate 2-10g, Mel 200-600g.
Another object of the present invention is to provide the using method of a kind of Chinese medicine external compound preparation treating threatened abortion,
This using method is: use acupuncture point application method, opens acupuncture point at two cun and apply note by lower back Shenshu cave i.e. second lumbar vertebra spinous process, the next day
1 time, one month be a course for the treatment of.
The Chinese medicine external compound preparation of the treatment threatened abortion that the present invention provides has another name called the antiabortive cream of kidney tonifying, and treatment is suffered from a deficiency of the kidney and caused
Frequent fetal movement disease and habitual abortion etc.；The Chinese medicine powder process ointment such as application Radix Codonopsis, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Scutellariae, Radix Dipsaci, Rhizoma Chuanxiong, use acupuncture point
Application method, lower back Shenshu cave (opening 2 cun by the 2nd spinous process of lumbar vertebra) acupuncture point applies note, the next day 1 time, within one month, be 1 course for the treatment of, medicine leads to
Cross local skin directly permeate and absorb, conduct through meridian point simultaneously, make medicine play its integrally-regulated effect, can be notable
Improve the lumbago symptom of frequent fetal movement patient；Shorten the transference cure times such as threatened abortion patient vaginal hemorrhage, stomachache, the soreness of waist；
Significantly improve clinic to prevent miscarriage success rate.
The Chinese medicine external compound preparation i.e. kidney tonifying antiabortive pasting exterior-applied therapeutic elder generation megastream of the treatment threatened abortion that the present invention provides
Producing, without obvious toxic-side effects, safety, easy, economical, patient acceptance is high, and curative effect certainly, is shortening vaginal hemorrhage, stomachache, waist
The acid transference cure time etc. has significant advantage, and the especially improvement of soreness of waist symptom solves the low efficient difficult problem of doctor trained in Western medicine, often
Rule anti-abortion medicine combines invention formulation and can significantly improve success rate of preventing miscarriage, and highlights characteristic and the advantage of Chinese medicine.
Accompanying drawing explanation
Fig. 1 is the preparation method flow chart of the Chinese medicine external compound preparation of the treatment threatened abortion that the present invention provides.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, to the present invention
It is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to
Limit the present invention.
Below in conjunction with the accompanying drawings the application principle of the present invention is explained in detail.
A kind of Chinese medicine external compound preparation treating threatened abortion, the Chinese medicine external compound preparation of this treatment threatened abortion is pressed
Weight ratio ingredient is: Radix Codonopsis 30-80g, Radix Angelicae Sinensis 30-80g, Radix Scutellariae 25-75g, Radix Paeoniae Alba 5-30g, Rhizoma Chuanxiong 5-30g, Rhizoma Atractylodis Macrocephalae 30-80g,
Pericarpium Citri Reticulatae 5-30g, Caulis Perillae 5-30g, Rhizoma Cyperi 5-30g, Cortex Eucommiae 5-30g, Radix Dipsaci 5-30g, Bulbus Fritillariae Thunbergii 5-30g, Radix Rehmanniae Preparata 50-120g, benzene first
Acid sodium 2-10g, Mel 200-600g.
As it is shown in figure 1, the preparation method of the Chinese medicine external compound preparation of the treatment threatened abortion of the embodiment of the present invention includes
Following steps:
S101: take Radix Rehmanniae Preparata, Radix Codonopsis is soaked, after being heated to boiling, little fire decocts, and filters medicinal residues, after boiling is filtered
Medicinal residues, filter, merging filtrate, be stirred continuously and be concentrated into paste, prepare concentrated solution；
S102: take Radix Angelicae Sinensis, Radix Scutellariae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Caulis Perillae, Rhizoma Cyperi, the Cortex Eucommiae, Radix Dipsaci, Bulbus Fritillariae Thunbergii all dry
Dry, pulverize and sieve, be mixed into scattered, add sodium benzoate, stir；
S103: take Mel appropriate, is heated to boiling, filters, and addition concentrated solution is with scattered mixture by several times, mixes all.
The preparation method of the Chinese medicine external compound preparation for the treatment of threatened abortion concretely comprises the following steps:
Take Radix Rehmanniae Preparata, half an hour soaked by Radix Codonopsis, and after being heated to boiling, little fire decocts 45 minutes, filters medicinal residues, boiling
30 minutes, filter, merging filtrate, be stirred continuously and be concentrated into paste；
Remainder medicine is dried, and pulverized 100 mesh sieves, and was mixed into scattered, adds sodium benzoate 5g, stirs；
Taking Mel appropriate, be heated to boiling, filter, addition concentrated solution is with scattered mixture by several times, mixes all.
The present invention provides the using method of a kind of Chinese medicine external compound preparation treating threatened abortion, and this using method is:
Use acupuncture point application method, open acupuncture point at two cun by lower back Shenshu cave i.e. second lumbar vertebra spinous process and apply note, the next day 1 time, within one month, be
One course for the treatment of.
Each raw material of Chinese medicine is explained as follows:
Radix Codonopsis: for the root of Campanulaceae Radix Codonopsis.Autumn excavates, and removes impurity, cleans, runs through, cut sheet, is dried.Not
Name Shangdang Radix Ginseng, Radix Saposhnikoviae Radix Codonopsis, Sphallerocarpus gracilis, preventing lanceolata, upper Radix Codonopsis, SHITOUSEN, middle Ganoderma.Sweet in the mouth, property is put down, is returned spleen, lung meridian.Spleen invigorating
Tonifying the lung, supplementing QI for promoting the production of body fluid.It is weak in kidney deficiency, spleen that frequent fetal movement is mainly blamed, and treats this disease spleen to be focused on kidney and rules together, and spleen kidney fills Sheng, gas
Blood is abundant, can carry fetal cultivation tire, faces card the kidney invigorating invigorating the spleen and benefiting QI to be earthed up.Radix Codonopsis has the effect of invigorating the spleen and benefiting QI, also takes it straight
Connect QI invigorating and carry tire, " benefit is got a point gas, peace get a point tire ".Radix Codonopsis also has suppression platelet aggregation, anti-blood clotting simultaneously
Effect.
Radix Angelicae Sinensis: for the root of umbelliferae angelica.Formal name used at school is Angelica sinensis, call dry return, horse hair Radix Angelicae Sinensis,
The Qin which, horse hair is returned, cloud is returned, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis.Typically must cultivate and just can gather for 3 years.Autumn end takes root, Ex-all stem and leaf, mud
Soil, is placed on ventilation and dries in the shade several days, be bundled into wisp the most respectively, smokes with low baking temperature and thoroughly and get final product in order.This product band oiliness, the most mould
Lose, damage by worms, it is necessary to storage is dried place.Meet intermittent drizzles in the rainy season seasons, must smoke with sulfur or suitable baking is saturating.Sweet in the mouth, pungent, bitter, warm in nature.Return
Liver, the heart, spleen channel.Function is enriched blood, is invigorated blood circulation, and menstruction regulating and pain relieving moisturizes laxation.Experiment confirms that Radix Angelicae Sinensis has hemopoietic to exempt from anti-anemia action, enhancing
Epidemic disease, calmness, analgesic activity.Radix Angelicae Sinensis volatile oil all has direct repression to the isolated uterine own pregnant, unpregnancy of many animals, makees
With rapid and lasting, uterus Rythmic contractions characteristic can be made to reduce, pituitrin, histamine, epinephrine and second phthalein can be resisted
The uterine contraction that choline etc. cause, makes uterus muscle relax, and blood flow is unobstructed, locally nutrition improvement, and the beneficially growth of embryo is sent out
Educate.
Radix Scutellariae: for the dry root of labiate Radix Scutellariae.Another name Radix Scutellariae, tsuchikane tea root.Spring, season in autumn two excavate, and remove
Fibrous root and silt, hit rough bark, dry after solarization.There are heat clearing and damp drying, eliminating fire and detoxication, the effect of arresting bleeding and miscarriage prevention.Compendium of Material Medica claims Huang
A kind of reed mentioned in ancient books " main gestation is antiabortive, the most multiplex it ".Radix Scutellariae had once been regarded as antiabortive panacea, discussed such as fire before managing out tire.Modern pharmacology also confirms
Radix Scutellariae has stronger inhibitory action to uterine myometrium.The enzyme activition system of Radix Scutellariae injury mastocyte, suppression inflammatory is anti-
Should be with reduction capillary permeability；Radix Scutellariae pathogenic fire purging, increases with suppression TNF-α, suppresses capillary permeability relevant.
The Radix Paeoniae Alba: for the dry root of ranunculaceae plant Radix Paeoniae.Another name Radix Cynanchi Otophylli.Summer, season in autumn two excavate, and clean, and remove end to end
And radicula, put and boil again after removing crust or peeling after boiling water boils, dry.This product is cylinder, straight or slightly bent, and two hold level with both hands
Cut, long 5～18cm, diameter 1～2.5cm.Surface off-white color or light red brown, bright and clean or have vertical wrinkle and a radicula trace, occasionally have residual
The sepia crust deposited.Matter is solid, is not easily broken, and section is flatter, off-white color or micro-strip brownish red, and cambium ring is obvious, penetrates
Line is radial.Bitter in the mouth, acid, cold nature.Return liver spleen channel.Function nourishes blood and seeks, relieving spasm to stop pain, holds back liver suppressing the hyperactive liver." property of medicine opinion ": " energy
Controlling convulsive abdominal pain, vim and vigour are gathered, and logical a surname's internal organs gather around gas, strong the five internal organs, the kidney invigorating gas, and married woman's blood closes obstructed." " Yaoxing Fu ": " fall its tire
Its liver can be damaged can delay wherein by its blood." essentials of Matea Medica says: " and enrich blood, eliminating pathogen in the liver, strengthening the spleen, hold back liver-yin, control the stomachache of blood deficiency ".Existing
Think that the Radix Paeoniae Alba has the slow lissive effect that specificity is good to uterus for pharmacological research, uterine myometrium is played suppression
Act on and alleviate uterus muscle spasm；Promote corpus luteum and developing womb.And have anoxia enduring, high temperature resistant, nourishing, strong and regulation machine
Body immune systems etc. act on.The most also have have calmness, convulsion, ease pain, lower the temperature, hepatoprotective, boosting, heart tonifying, antiinflammatory, antithrombotic
Deng effect.
Rhizoma Chuanxiong: this product is samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort. (or Ligusticum
Wallichii Franch.) dry rhizome.Summer is significant prominent when the joint dish on stem, and excavates during purplish, removes mud
Sand, after solarization, a heatable brick bed is done, then removes fibrous root.Another name: rhizome of chuanxiong, Rhizoma Chuanxiong.Perennial herb, high 30～60 centimetres, root stock is in not advising
Nodositas fist shape then, there are stem foot agglomerate, crust yellowish-brown in tuberosity top, have fragrance.Stem constant is grown thickly, uprightly, and upper part
Branch, internode hollow, bottom joint substantially enlarges into root shape, easily takes root.Leaf alternate, two to three times winglike compound leaves.Summer-flowering, multiple umbrella
Shape inflorescence top is raw, diachenium oval, and 5 ribs have narrow wing, have 1, oil pipe, have 2 in incline in heel, and faying face has 4.This
Product are irregular nodular pattern fist shape agglomerate, diameter 2～7cm.Surface yellowish-brown, coarse shrinkage, there is the wheel of most parallel ridges to save,
Top has on the similar round stem trace of depression, downside and wheel joint and has most little warty root trace.Matter is solid, is not easily broken, section HUANGBAI(sic)
Color or lark, dissipate the grease chamber having yellowish-brown, and cambium layer is wavy ring grain.Acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Function is lived
Blood and dissolving stasis, activating QI to alleviate the depression, wind-expelling pain-stopping.Treatment the recipe Chinese angelica powder of abdominal pain during pregnancy, DANGGUI SHAOYAO SAN, the Rhizoma Atractylodis Macrocephalae of Zhong Jing initiative
Dissipate, in Ass-hide Glue and Argyi Leaf Decoction, all contain Rhizoma Chuanxiong.Wherein the Rhizoma Atractylodis Macrocephalae dissipates is one " fetus nourishing " prescription.Constituents extraction is carried out, from river by modern crafts
Rhizome of chuanxiong can obtain alkaloid ligustrazine, there is blood circulation promoting and blood stasis dispelling, improve the effect such as microcirculation, make preparation and can treat fetal in utero and send out
It is slow to educate.
The Rhizoma Atractylodis Macrocephalae: for thousand dry rhizomes of the feverfew Rhizoma Atractylodis Macrocephalae.The thousand dry rhizomes for the feverfew Rhizoma Atractylodis Macrocephalae.Another name small wooden raft Ji, Rhizoma Atractylodis Macrocephalae,
The winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, sheet art, Rhizoma Atractylodis etc..Inferior leads blessing in winter is yellow, upper leaf is excavated when becoming fragile, and removes silt, dries
Do or dry, then removing fibrous root.Bitter in the mouth, sweet, warm in nature.Return taste warp.Function invigorating the spleen and benefiting QI, dampness row water, hidroschesis, antiabortive.In vain
The Fang Zhongjun such as art is antiabortive key medicine, famous DANGGUI SHAOYAO SAN, and the Rhizoma Atractylodis Macrocephalae dissipates, Taishan Panshi San contain the Rhizoma Atractylodis Macrocephalae.The Rhizoma Atractylodis Macrocephalae is as spleen invigorating
QI invigorating medicine, can increase antibody tormation, it may also be used for treatment rheumatism.Modern medicine viewpoint is thought, rheumatoid arthritis belongs to
In cell-mediated autoimmune disease, during gestation, mother's immune system is situated between based on TH2 reaction (immunity of humoral), cell
The TH1 immunoreation led declines, thus arthritic symptom alleviates.The Rhizoma Atractylodis Macrocephalae can treat rheumatism prompting can to cell-mediated immunity
Can there is certain inhibitory action.Radix Scutellariae, Rhizoma Atractylodis Macrocephalae compatibility, can suppress cell immune response, suppresses TH1 cytokine-expressing, strengthens anti-
The immunity of body mediation, strengthens TH2 reaction, thus is conducive to gestation.
Pericarpium Citri Reticulatae: for rutaceae orange and the dry mature skin of variety thereof.Another name Pericarpium Citri tangerinae.Medical material is divided into " Pericarpium Citri Reticulatae "
" Pericarpium citri reticuatae chachiensis ".Harvesting ripe fruit, strips peel, dries or cold drying.Pericarpium Citri Reticulatae often shells into several lobe, and base portion is connected, and has
In irregular lamellar, thick 1～4mm.Outer surface is orange red or rufous, has fine wrinkle and recessed point-like grease chamber；Inner surface
Ivory buff, coarse, attached yellow-white or yellowish-brown grain shape vascular bundle.Matter is the hardest and crisp.Acrid in the mouth, hardship, warm in nature.Return spleen, stomach, lung
Warp.Function regulating QI and lowering the adverseness, whets the appetite in tune.In " Tai Ming the Bureau of People's Welfare Pharmacies side ", Xiangsu San is a recipe, and this side can treat gas
The frequent fetal movement that resistance causes.Pericarpium Citri Reticulatae and Rhizoma Cyperi compatibility in side, modern pharmacological research confirms, has the uterotonic effect of suppression, peace
Tire effect is good.
Caulis Perillae: for the dry stem of labiate Folium Perillae.Autumn taps after fruit maturation, removes impurity, dries, or take advantage of fresh
Section, dries.This product is square column type, the four blunt circles of rib, different in size, diameter 0.5～1.5cm.Surface purple brown or mulberry, four
There are longitudinal furrow and thin longitudinal grin in face, and joint portion slightly expands, and has raw branch trace and leaf scar.Body is light, and matter is hard, section splintery.Slice thick 2～
5mm, often square in plagioclase, woody part yellow-white, ray is fine and closely woven, radially, and marrow white, loosen or come off.Acrid in the mouth, warm in nature.
Return lung, spleen, stomach warp.Function regulating the flow of QI to ease the stomach, antiabortive, and blood.Research shows that Caulis Perillae different parts extract can significantly reduce low
Whole blood viscosity, erythrocyte aggregation index and erythrocyte electrophoresis index when cutting, and can pole whole blood reduction when significantly reducing undercut
Viscosity.Animal uterus inner membrance enzymatic activity is excited by research confirmation Caulis Perillae has similar pharmacological action to progesterone.Therefore purple
Caulis Perillae is used for treating threatened abortion and antiabortive mechanism is also same as progesterone.
Rhizoma Cyperi: this product is the dry rhizome of sedge dried tuber Cyperus rotundus L..Autumn excavates, and burns
Feeler, puts and dries after slightly boiling or steam in boiling water, or directly dries after burning.Another name dried tuber, Rhizoma Cyperi, Thunder God head, Herba Caricis Phacotae, perfume (or spice)
Careless, the blueest or green, passeris montani saturati head is fragrant.This product is many in spindle, the slightly curved song having, and long 2～3.5cm, diameter 0.5～1cm.Surface is brown
Color or pitchy, have vertical wrinkle, and have 6～10 links slightly swelled, and joint has brown feeler and the fibrous root mark of break of non-Ex-all；
Person is more smooth to remove feeler, and link is inconspicuous.Matter is hard, through steaming and decocting person's section yellowish-brown or rufous, cutin sample；Sun-dried person's section
Color Bai Erxian mealiness, endodermis ring grain is obvious, and center pillar color is relatively deep, and point-like vascular bundle is dispersed in.Acrid in the mouth, hardship sweet, micro-, property is put down.Return liver,
Tri-jiao channel.Regulate the flow of vital energy resolving depression, menstruction regulating and pain relieving, antiabortive.Modern pharmacological research confirms that Rhizoma Cyperi has estrogen-like effects, simultaneously to animal
Isolated uterine, the most own pregnant or unpregnancy, there is inhibitory action so that it is contractility weakens, muscular tension reduces.
The Cortex Eucommiae: this product is the dry bark of the Eucommiaceae plant Cortex Eucommiae, is Chinese famous and precious tonic herb.Have another name called bakelite.Sweet in the mouth,
Micro-pungent, warm in nature.Return liver, kidney channel.Function invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Shennong's Herbal: " cure mainly pain along the spinal column, invigorating middle warmer, benefit essence
Gas, hard muscles and bones." " property of medicine solution ": " main uncontrolled urination itches, dribbling urination, and strong will strengthening bone and muscle, nourishing kidney stops pain in the lumbar region." Jing-Yue Complete Works:
" its merit enters kidney, the strong will of invigorating middle warmer, and strong kidney adds essence, lumbago distinguished service, because of its temperature, therefore warms up uterus；Because its property is solid, therefore antiabortive gas." existing
Generation research confirms that the Cortex Eucommiae can significantly improve cAMP and cGMP level in blood, makes animal activity power improve.Possess enhancing body fluid to exempt from
Epidemic disease function, antibacterial, antitumor.The spontaneous activity of the notable antagonism Mus isolated uterine of energy so that it is frequency and contraction intensity are subject to
Suppression.Additionally can promote the metabolism of protein collagen in the various tissues of human body, to aging-resistant effect.Additionally there is town
The effects such as bitterly, analgesia, heart tonifying, blood pressure lowering, diuresis, rush blood glucose increase.
Radix Dipsaci: for the root of herbaceos perennial Radix Dipsaci, gain the name because of energy " synthetism of continuous folding ".Also name Radix Dipsaci, in Radix Dipsaci
Medicine name.For the root of herbaceos perennial Radix Dipsaci, gain the name because of energy " synthetism of continuous folding ".Autumn excavates, and removes root head and fibrous root,
It is dried to low baking temperature half-dried, when bank up " diaphoresis " is to internal virescence, then dries.Bitter in the mouth, pungent, slightly warm in nature.Return liver, kidney channel.Function
Invigorating the liver and kidney, bone and muscle strengthening, blood circulation regulating, only metrorrhagia." book on Chinese herbal medicine converges and says " claims Radix Dipsaci " pregnant this uneasiness non-of tire damaged ".It is usually used in treating liver
Kidney deficiency, infertile, the fetal movement of Chong and Ren channel disorder is intended to fall or metrorrhagia and metrostaxis is through many etc.." property of medicine solution ": " main typhoid fever foot, physical strength profiting, continuous muscle
Bone warms up uterus, treats lumbago and adjusts blood and blood." " Japan hanako materia medica " is stated Radix Dipsaci feasible controlled atmosphere blood, before treatment married woman's tire puerperal all
Disease, infertility, vaginal bleeding during pregnancy etc.." in essentials of Matea Medica opinion its can mend the deficiency of zang-fu differentiation, logical blood network and strong muscles and bones." existing
Confirm that Radix Dipsaci contains abundant vitamin E for pharmacology, be effectively improved its deficiency disease have estrogenic activity, composition to swash with receptor
Element is similar.Isolated uterine is had stronger excitation.Corpus luteum can be promoted generate, promote that embryo cutting, suppression uterus are put down
Sliding flesh shrinks.Additionally can suppress Diplococcus pneumoniae, carbuncle and ulcer is had the effect of analgesia, evacuation of pus, hemostasis, tissue regeneration.To trichomonas
Vaginitis has insecticidal action.
Bulbus Fritillariae Thunbergii: this product is the dry bulb of liliaceous plant Bulbus Fritillariae Thunbergii.Another name Bulbus Fritillariae Thunbergii, Bulbus Fritillariae Thunbergii, BULBUS FRITILLARIAE THUNBERGII, pearl shellfish.Early summer
Excavate when plant withers, clean.Separately, big person removes core bud to size, practises and claims " Bulbus Fritillariae Thunbergii "；Little person not coring bud, practises and claims " pearl shellfish ".
Hit wiping respectively, remove crust, mix the conch meal forged, suck the juice clashed, be dried；Or taking bulb, size separately, is washed
Only, remove core bud, take advantage of fresh-cut and become sheet, cleaning, drying, practise and claim " Bulbus Fritillariae Thunbergii sheet ".Its character is: Bulbus Fritillariae Thunbergii: for the list of bulb outer layer
Lobe scale leaf, slightly in crescent, high 1～2cm, diameter 2～3.5cm.Outer surface off-white color is to faint yellow, and inner surface is white or light brown
Color, is had white powder.Matter is hard and crisp, frangibility, section white to yellow-white, richness mealiness.Feeble QI, mildly bitter flavor.Pearl shellfish: for complete
Whole bulb, in oblateness, high 1～1.5cm, diameter 1～2.5cm.Surface off-white color, outer layer scale leaf 2 lobe is plump, slightly like kidney
Shape, mutual obvolvent, inside there are little scale leaf 2～3 pieces and the residual stem of drying shrinkage.Bulbus Fritillariae Thunbergii sheet: the sheet being cut into for the single-lobe scale leaf of bulb outer layer.
Ellipse or similar round, diameter 1～2cm, edge surface is faint yellow, and tangent plane is smooth, white powder.Matter is crisp, frangibility, section whitewash
Color, rich mealiness.Sweet in the mouth, hardship, cold nature.Return lung, heart channel.Function removing heat-phlegm, sending down the abnormal ascending QI cough-relieving, mass dissipating and swelling eliminating.Huangdi's Internal Classics
Cloud: " its person of kidney meridian of Foot-SHAO YIN is passed through liver diaphragm from kidney, entered in lung ", " shaoyin meridians passes through kidney network lung ", i.e. clearly state kidney channel with
Lung meridian existence passes through contact through pulse-phase, and lung and kidney also exist close contacting.This contact is embodied in clinic: at course advancement
On, kidney disease and the mutual change of disease of pneumonopathy, influence each other, Chinese medicine is referred to as " change of disease ".Wherein, " illness of the mother organ affecting the child one " refers to
Pathological changes by mother dirty involve son dirty.The lung belonging to metal, kidney belongs to water, and by the rule of metal generating water, lung is female dirty, and kidney is that son is dirty.The raw kidney of lung, lung
The clear respectful descending improving inspiration by invigorating kidney-QI contributing to kidney of gas, pneumonopathy and kidney can cause " failure of the kidney in receiving QI ".Deficiency of kidney-QI causes miscarriage to occur.In diagnosis and treatment
On, the disease lung to be controlled of kidney.This side adds Bulbus Fritillariae Cirrhosae and takes lung moistening the moon, the effect of lower kidney nourishing water on it.
Radix Rehmanniae Preparata: for the Preparation process product of Radix Rehmanniae.This product is irregular piece of sheet, fragment, and size, thickness differ.Surface
Corvinus, glossy, stickiness is big.Matter is soft and band toughness, is not easily broken, section corvinus, glossy.Sweet in the mouth, warm in nature.Return
Liver, kidney channel.Function is enriched blood YIN nourishing, and benefit essence fills out marrow, cooling blood for hemostasis.Threatened abortion and habitual abortion belong to motherland's medical science " vaginal bleeding during pregnancy ",
The category such as " frequent fetal movement ", " habitual abortion ", " abortion ", the primary disease cause of disease mainly has feotus vitality and two aspect reasons of parent.Feotus vitality aspect,
How not enough because of the vital essence of Mr. and Mrs, though two essences can be in conjunction with, but liability to abortion and there is vaginal bleeding during pregnancy, frequent fetal movement.Parent aspect is because of pregnant
Woman's ferritic is weak, and insufficiency of vital energy and blood, instability of kidney QI, deficiency of kidney-essence, tire is without being supported.The replenishing essence of Radix Rehmanniae Preparata nourishing YIN for benefiting the kidney, the peace of tire is no to be lain in
Kidney, therefore kidney tonifying can be antiabortive.
Sodium benzoate (chemical formula: C6H5CO2Na): be benzoic sodium salt.Sodium benzoate belongs to acid preservative, conventional
Food preservative, have and prevent the rotten effect turned sour, extend the shelf life, be all widely used in countries in the world.Sodium benzoate
Being mostly white particle, odorless or micro-strip Benzoinum abnormal smells from the patient, taste is micro-sweet, has convergence, soluble in water；The optimal PH of its anticorrosion is
2.5-4.0.Sodium benzoate lipophile is relatively big, and easy permeates cell membranes enters in cyton, the permeability of interference cell film, and suppression is thin
After birth is to amino acid whose absorption；Enter cyton internal ionization and be acidified the storage of intracellular alkali, and suppress the work of the respiratory enzyme system of cell
Property, stop S-acetyl-coenzyme-A condensation reaction, thus play the purpose of food antiseptic.
Mel: this product is Apidae insecticide apis cerana Apis cerana Fabricius or apis mellifera Linnaeus APis
The honey that mellifera Linnaeus is made.Spring gathered to autumn, filtered.This product is translucent, band gloss, thick liquid,
White is to the most faint yellow or crocus to yellowish-brown, and putting for a long time or meeting cold gradually has white granular crystallization.Gas fragrance, taste is the sweetest.
Relative density this product, if any crystallization, is placed in the water-bath less than 60 DEG C, after whole thawings to be crystallized, stirs evenly, is cooled to
25℃.Property sweet, taste put down.Effective to hypochrosis.After treatment, blood cell and hemoglobin have significant increase.The most daily 80～
100g, point 3 clothes.Additionally, to chronic diseases such as neurasthenia, hypertension, pulmonary tuberculosis, heart disease, hepatopathies, Mel for oral administration is also
There is certain therapeutical effect or adjust benefit effect, generally as adjuvant drug.
Below in conjunction with clinical data, the application effect of the present invention is explained in detail.
Embodiment one:
One women, at 28 years old age, ultrasound diagnosis uterine pregnancy tire alive 52 days, waist hypodynia, lower abdomen muscle hangs, and occasionally having feels sick vomits
Telling, without stomachache, absence of vagina is hemorrhage, without dizziness headache.Light red tongue, white and thin fur, thready and rolling pulse.Allow it use Shenshu cave and stick the present invention
Plaster, the next day once, after first quarter moon, patient's lumbago is obviously improved, rear for consolidating the state of an illness, completes the course for the treatment of of one month, Huan Zhewei
Telling lumbago symptom again, therapeutic effect is obvious.
Embodiment two:
One women, at 34 years old age, gestation 48 days, lower abdomen dull pain companion's soreness of waist 1 day, absence of vagina is hemorrhage, without nausea and vomiting, without a head
Dizzy headache, the most continuously spontaneous abortion 2 times.Light red tongue, white and thin fur, thready pulse.Allow it use Shenshu cave and stick the plaster of the present invention
Patch, the next day once, after sticking one month continuously, patient tells lumbago symptom the most again, and lower abdomen dull pain also disappears, and follow up a case by regular visits to give a birth a man
Baby, therapeutic effect is obvious.
Detailed description of the invention:
1 clinical data and method
Case selection and inclusive criteria: all cases are all from January, 2014～institute of traditional Chinese medicine of in December, 2015 Wenzhou City woman
Section's outpatient service, with in hospital, is diagnosed as threatened abortion, and Chinese medical discrimination meets the patient of renal deficiency type vaginal bleeding during pregnancy or frequent fetal movement.
1.1 diagnostic criterias: 1. Western medicine diagnose standard: according to " obstetrics and gynecology ", " new Chinese medicine guideline of clinical investigations "
Draft for: medical history has menolipsis history and morning sickness；Symptom vagina is the most hemorrhage, with lower abdomen pendant pain or soreness of waist pain；Blood chorion
Promoting sexual gland hormone raises；Gynecologial examination cervical orifice is not opened, and body of uterus is soft, size and pregnant Zhou Xiangfu；Ultrasound diagnosis uterus size,
Pregnant capsule or embryo (fetus) grow and pregnant Zhou Xiangfu.2. Standards of Chinese Medical Syndrome Differentiation is formulated according to " Gynecology of Chinese Medicine ".Frequent fetal movement kidney
Deficiency: a small amount of hematochezia of trimester of pregnancy vagina, color is dim, soreness of waist abdomen pendant pain.Or companion's dizziness and tinnitus, frequent micturition, frequent urination at night is even lost
Prohibit, or have an abortion the most time and again, pale tongue with white fur, deep-rolling pulse CHI-pulse being weak.
1.2 exclusion standards: be 1. diagnosed as the diseases such as ectopic pregnancy, missed abortion, inevitable abortion, hydatidiform mole, placenta previa
Person.2. both sides' chromosome analysis person of noting abnormalities.3. gynecological tumor or reproductive malformation person it are associated with.4. allergic constitution or to many
Plant drug allergy person.5. serious internal disease patient it is associated with.As being associated with nerve, mental disease, or it is reluctant partner.
1.3 inclusive criterias: be 1. diagnosed as threatened abortion, Chinese medical discrimination meets the patient of renal deficiency type frequent fetal movement；The most pregnant age <
12 weeks；3. other drug treatment it is provided without before treatment；4. the age is between 20～40 years old.
2 Therapeutic Method
2.1 packet medications: 232 example patients, take random controls method, are divided into Chinese medicine composition group of the present invention and Western medicine comparison
Group is treated.Chinese medicine composition group 127 example the most of the present invention, western medicine group 105 example.Western medicine group gives Progesterone
Pin, each 20mg, intramuscular injection, every day 1 time, it is used in conjunction 14 days；Dydrogesterone sheet 10mg, every 12 hours 1 time, is used in conjunction 30 days.In
Drug composition treatment group adds on the basis of matched group uses the lower back Shenshu cave point application antiabortive cream of kidney tonifying, the next day 1 time, even
Continue and use 30 days.The two groups of the most prohibitive lives of patient of medication period, enough nutritional supports, keep being emotionally stable, the necessary heart
Reason comfort and guidance.Observation index: observe treatment external genitalia and anus gastrointestinal hemorrhage, lower abdominal pain, the improvement situation of soreness of waist pain.
2.2 criterion of therapeutical effect
2.2.1 clinical efficacy standard is divided into recovery from illness, effective and invalid.With reference to " obstetrics and gynecology ", " new Chinese medicine clinical research
Guideline " formulate.1. recovery from illness: the transference cures such as vaginal hemorrhage stops, soreness of waist pain of suffering from abdominal pain, B ultrasonic prompting fetal development is good.②
Effective: still having a small amount of vaginal hemorrhage, or still have slight stomachache soreness of waist pain, B ultrasonic prompting fetal development is good.The most invalid: vagina goes out
Blood does not reduces, and even increases, and stomachache soreness of waist pain does not alleviates, and even increases the weight of, B ultrasonic prompting embryo's stasi.
2.2.2 soreness of waist symptom improves criterion of therapeutical effect: 1. recovery from illness: soreness of waist symptom is wholly absent, B ultrasonic prompting fetal development is good
Good.The most effective: even have the soreness of waist, and day, attack times was less than 3 times, and B ultrasonic prompting fetal development is good.The most invalid: the soreness of waist does not alleviates, very
To increasing the weight of, B ultrasonic prompting embryo's stasi.
3 results
3.1 efficacy determinations: after 1 course for the treatment of of 232 example frequent fetal movement patient treatments, in treatment group 127 example, 96 examples recoveries from illness, 15
Example is effective, and 6 examples are invalid, and effective percentage is 95.28%, and in matched group 105 example, 82 example recoveries from illness, 6 examples are effective, and 14 examples are invalid, effective percentage
Being 86.67%, two groups of effective percentage compare, and difference is statistically significant, and treatment group treatment curative effect is higher than matched group.It is shown in Table 1.
1 liang of table group patient clinical comparitive study
Note: X 2 test, statistic=5.408, P=0.020, P ＜ 0.05, there is statistical significance.
3.2 symptoms improve situation
3.2.1 lumbago symptom improves situation: this research is extracted the frank patient of lumbago, and to two groups of patient's lumbagos
The treated effect of symptom is contrasted, after 1 course for the treatment of of 215 example frequent fetal movement patient treatments, in treatment group 118 example, and 102 examples
Recovery from illness, 15 examples are effective, and 1 example is invalid, and effective percentage is 99.15%, in matched group 97 example, 41 examples recovery from illness, 17 examples are effective, 39 examples without
Effect, effective percentage is 59.79%, and two groups of effective percentage compare, and difference is statistically significant, and treatment group is to threatened abortion patient's soreness of waist disease
The effective percentage of shape is significantly better than matched group.It is shown in Table 2.
The treated effect of 2 liang of table group patient's lumbago symptom compares
Note: X 2 test, statistic (X2)=0.024, P=0.000, P ＜ 0.005, there is statistical significance.
3.2.2 the clinical symptom disappearance time compares
Chinese medicine composition is the most effective in cure to symptoms such as vaginal hemorrhage, stomachache and the soreness of waist of frequent fetal movement patient, and treatment group is each
The kind transference cure time is all shorter than matched group, and wherein particularly evident to improving patient's soreness of waist curative effect, difference is the most statistically significant,
It is specifically shown in following table.
3 liang of the table group patient's bleeding transference cure time compares
Note: be independent samples t test: P=0.000, P ＜ 0.05, has statistical significance.
4 liang of table group patient's colic symptoms extinction time compares
Note: be independent samples t test: P=0.000, P ＜ 0.05, has statistical significance.
5 liang of table group patient compare the soreness of waist transference cure time
Note: be independent samples t test: P=0.000, P ＜ 0.05, has statistical significance.
The kidney tonifying that the present invention provides is antiabortive.Treatment suffer from a deficiency of the kidney cause frequent fetal movement, habitual abortion etc..
The positive greatly chief physician of national famous physician horse acts on the principle of external treatment with Chinese medicine, makes the antiabortive cream of kidney tonifying by oneself, application Radix Codonopsis,
Cream is received in the Chinese medicine powder process such as Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Scutellariae, Radix Dipsaci, Rhizoma Chuanxiong, uses acupuncture point application method, lower back Shenshu cave (the 2nd lumbar vertebra spine
Prominent side opens 2 cun) acupuncture point applies note, the next day 1 time.It within one month, it was 1 course for the treatment of.Medicine directly permeates and absorbs by local skin, simultaneously
Conduct through meridian point, make medicine play its integrally-regulated effect, the lumbago symptom of frequent fetal movement patient can be significantly improved, contracting
Short vaginal hemorrhage, stomachache, the extinction time of the big threatened abortion primary symptom of the soreness of waist three, clinical efficacy is definite.
Kidney tonifying antiabortive pasting exterior-applied therapeutic frequent fetal movement, without obvious toxic-side effects, safety, simplicity, economy, patient acceptance
Height, certainly, in the time shortening vaginal hemorrhage, improve the symptoms such as stomachache, the soreness of waist has significant advantage to curative effect, improves and prevents miscarriage successfully
Rate, highlights characteristic and the advantage of Chinese medicine.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Any amendment, equivalent and the improvement etc. made within god and principle, should be included within the scope of the present invention.
Claims (4)
1. the Chinese medicine external compound preparation treating threatened abortion, it is characterised in that the Chinese medicine external of this treatment threatened abortion
Compound preparation by weight component is: Radix Codonopsis 30-80g, Radix Angelicae Sinensis 30-80g, Radix Scutellariae 25-75g, Radix Paeoniae Alba 5-30g, Rhizoma Chuanxiong 5-30g,
Rhizoma Atractylodis Macrocephalae 30-80g, Pericarpium Citri Reticulatae 5-30g, Caulis Perillae 5-30g, Rhizoma Cyperi 5-30g, Cortex Eucommiae 5-30g, Radix Dipsaci 5-30g, Bulbus Fritillariae Thunbergii 5-30g, Radix Rehmanniae Preparata
50-120g, sodium benzoate 2-10g, Mel 200-600g.
2. the preparation method of the Chinese medicine external compound preparation of a treatment threatened abortion as claimed in claim 1, it is characterised in that
The preparation method of the Chinese medicine external compound preparation of this treatment threatened abortion comprises the following steps:
Take Radix Rehmanniae Preparata, Radix Codonopsis is soaked, and after being heated to boiling, little fire decocts, and filters medicinal residues, the medicinal residues after boiling filtration, mistake
Filter, merging filtrate, it is stirred continuously and is concentrated into paste, prepare concentrated solution；
Take Radix Angelicae Sinensis, Radix Scutellariae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Caulis Perillae, Rhizoma Cyperi, the Cortex Eucommiae, Radix Dipsaci, Bulbus Fritillariae Thunbergii are all dried, and pulverize
Sieve, is mixed into scattered, adds sodium benzoate, stirs；
Take Mel, be heated to boiling, filter, add in concentrated solution and scattered mixture by several times, mix all.
3. the preparation method of the Chinese medicine external compound preparation for the treatment of threatened abortion as claimed in claim 2, it is characterised in that control
The preparation method of the Chinese medicine external compound preparation treating threatened abortion concretely comprises the following steps:
Take Radix Rehmanniae Preparata, half an hour soaked by Radix Codonopsis, and after being heated to boiling, little fire decocts 45 minutes, filters medicinal residues, boiling 30 points
Clock, filters, merging filtrate, is stirred continuously and is concentrated into paste；
Remainder medicine is dried, and pulverized 100 mesh sieves, and was mixed into scattered, adds sodium benzoate, stirs；
Take Mel, be heated to boiling, filter, add in concentrated solution and scattered mixture by several times, mix all.
4. a using method for the Chinese medicine external compound preparation for the treatment of threatened abortion as claimed in claim 1, its feature exists
In, described using method is: use acupuncture point application method, opens acupuncture point at two cun and apply by lower back Shenshu cave i.e. second lumbar vertebra spinous process
Note, the next day 1 time, within one month, be a course for the treatment of.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116270846A (en) * | 2023-03-27 | 2023-06-23 | 苏州市吴江区中医医院（苏州市吴江区第二人民医院） | Traditional Chinese medicine compound composition for treating placenta pre-symptoms in middle pregnancy and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305840A (en) * | 2000-12-29 | 2001-08-01 | 冉五振 | Medicine for preventing and treating abortion |
| CN103071105A (en) * | 2013-02-06 | 2013-05-01 | 孙迎春 | External traditional Chinese medicinal preparation for treating threatened abortion and preparation method thereof |
-
2016
- 2016-08-09 CN CN201610647738.6A patent/CN106177396A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305840A (en) * | 2000-12-29 | 2001-08-01 | 冉五振 | Medicine for preventing and treating abortion |
| CN103071105A (en) * | 2013-02-06 | 2013-05-01 | 孙迎春 | External traditional Chinese medicinal preparation for treating threatened abortion and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116270846A (en) * | 2023-03-27 | 2023-06-23 | 苏州市吴江区中医医院（苏州市吴江区第二人民医院） | Traditional Chinese medicine compound composition for treating placenta pre-symptoms in middle pregnancy and preparation method and application thereof |
| CN116270846B (en) * | 2023-03-27 | 2024-05-03 | 苏州市吴江区中医医院（苏州市吴江区第二人民医院） | Traditional Chinese medicine compound composition for treating placenta pre-symptoms in middle pregnancy and preparation method and application thereof |
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Application publication date: 20161207 |