CN101884722B - Medicament for treating chyluria and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for treating chyluria, which is prepared from the raw material medicaments according to proportion: cherokee rose fruit, plantain seed, rhizome dioscoreae hypoglaucae, rehmanniae vaporata, cinnamomvine, Chinese angelica, cortex phellodendri. The medicament for treating the chyluria has the effects of clearing heat and promoting diuresis and isolating clear and dissolving turbidity, and has the advantages of quick response and high cure rate.

Description

A kind of medicine for the treatment of chyluria and preparation method thereof

Technical field:

The present invention relates to a kind of medicine for the treatment of chyluria and preparation method thereof, belong to the field of Chinese medicines.

Background technology:

Chyluria is that near-end intralymphatic pressure raises because the lymphatic vessel pathological changes causes blocking of lymphatic vessel generation mechanicalness or dynamic property, and the lymphatic vessel under the mucous membrane of renal pelvis breaks and produces the renal pelvis lymphatic fistula, and chyle liquid enters and forms chyluria in the urine.The thick turbid as wadding of the urine that has, not smooth during urine, urethral obstruction; Be with pale red in the turbid greasy urine that has, many nothing pains.Daily diagnosis and treatment are done perfusion in the renal pelvis with 10% silver nitrate solution usually, and certain effect is arranged, but recurrence easily.Adopting operative treatment is that kidney base of a fruit lymphatic vessel is cut off separating operation, or kidney lymphatic vessel and lumbar trunks anastomosis, great saphenous vein and inguinal lymph nodes anastomosis etc., and postoperative also has recurrence, and operation is comparatively complicated.

Summary of the invention:

Therefore people to curative effect preferably the Chinese medicine medicine have great demand, up to now, also do not find relevant report about medicine of the present invention, the inventor is through research repeatedly, and the checking repeatedly by clinical trial, finally worked out the Chinese medicine medicine of treatment chyluria, thereby finished the present invention with better curative effect.

Purpose of the present invention just provides a kind of Chinese medicine medicine of more effectively treating chyluria.

Another object of the present invention has just provided the preparation method of this Chinese medicine medicine.

Medicine of the present invention selects Fructus Rosae Laevigatae, Semen Plantaginis, Semen Caesalpiniae Minacis, Rhizoma Osmundae, Rhizoma Belamcandae, Rhizoma Dioscoreae Septemlobae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Radix Angelicae Sinensis, Semen Euryales, the Rhizoma Anemarrhenae, Cortex Phellodendri to make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of chyluria.Select for use Fructus Rosae Laevigatae to be because its nature and flavor are sour and astringent, flat.Go into kidney, bladder, large intestine channel.Control spermatorrhea, the enuresis, frequent micturition, insufficiency of the spleen dysentery, the deficiency of the lung is breathed with cough, spontaneous sweating, bleeding not during menses.It is sweet owing to its nature and flavor, cold selecting its Semen Plantaginis for use.Go into kidney, urinary bladder channel.Diuretic, heat clearing away makes eye bright, and eliminates the phlegm.Control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, the heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.Select for use Semen Caesalpiniae Minacis to be because its nature and flavor are sweet, cold.Go into heart spleen kidney three warps.Fasting dysentery; Vomiting is not eaten; Vexed insomnia; Seminal emission; Turbid urine; Leukorrhagia.Selecting Rhizoma Osmundae for use is owing to its nature and flavor hardship, cold, goes into liver, stomach warp.Kill ascarid, silk ribbon, burning worm, heat clearing away, detoxifcation, removing heat from blood, hemostasis.Control anemopyretic cold, warm skin eruption is spitted blood epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia.Select for use Rhizoma Belamcandae to be because its nature and flavor hardship is cold, poisonous.Go into lung, Liver Channel.Pathogenic fire reducing, detoxifcation, the blood that looses, expectorant.Control the sore throat pharyngalgia, cough with dyspnea, accumulation and obstruction of sputum, scrofula tuberculosis, malaria with splenomegaly, women's amenorrhea, carbuncle sore tumefacting virus.Select for use Rhizoma Dioscoreae Septemlobae to be because its nature and flavor hardship, flat is gone into liver, stomach, urinary bladder channel.Dampness removing goes turbid, and eliminating impediment dispels the wind.Be used for stranguria marked by chyluria, nebulousurine, leukorrhagia, rheumatic arthralgia, articular instability, lumbocrural pain.Select for use Radix Rehmanniae Preparata be since its nature and flavor sweet, tepor, return through, return liver, kidney channel, cure mainly nourishing YIN and supplementing blood, beneficial essence is filled out marrow, is used for the hepatic and renal YIN deficiency, soreness of the waist and knees, hectic fever due to YIN-deficiency, hectic fever, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.It is sweet owing to its nature and flavor, flat selecting Rhizoma Dioscoreae for use.Go into lung, spleen, kidney channel.Strengthening the spleen and tonifying the lung reinforces the kidney, and benefit is smart.Control diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease is quenched one's thirst, seminal emission, leukorrhagia, frequent micturition.Selecting Radix Angelicae Sinensis for use is owing to the sweet suffering of its nature and flavor, temperature.Go into the heart, liver, spleen channel.Benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the effect of moisturizing laxation.Control menoxenia, amenorrhea stomachache, the lump in the abdomen knot is poly-, metrorrhagia, headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, the dryness of the intestine dyschezia, heavy after the bloody dysentery, ulcer sores, injury from falling down.Select for use Semen Euryales to be because its property sweet-puckery flavor is flat.Go into spleen, kidney channel.Reinforcing the kindey to control nocturnal emission, the spleen reinforcing stopping leak.Control seminal emission, stranguria with turbid discharge, leukorrhagia, incontinence of urine, loose stool and diarrhea.Select for use the Rhizoma Anemarrhenae to be because its nature and flavor hardship, cold.Go into lung, stomach, kidney channel.Nourishing YIN to lower pathogenic fire is moisturized laxation.Control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select for use Cortex Phellodendri to be because its nature and flavor hardship, cold.Go into kidney, urinary bladder channel.Heat clearing away, dampness, pathogenic fire purging, detoxifcation.Control hematodiarrhoea, have loose bowels, jaundice, flaccidity is warded off, nocturnal emission, stranguria with turbid discharge, hemorrhoid are had blood in stool, leucorrhea with red and white discharge, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, skin ulcer phleboedesis poison.

The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following weight range:

Fructus Rosae Laevigatae 15-25 gram Semen Plantaginis 15-25 gram Semen Caesalpiniae Minacis 25-35 gram

Rhizoma Osmundae 15-20 gram Rhizoma Belamcandae 18-22 Ke Rhizoma Dioscoreae Septemlobae 15-25 gram

Radix Rehmanniae Preparata 18-25 Keshan medicine 14-22 gram Radix Angelicae Sinensis 10-20 gram

Semen Euryales 15-22 gram Rhizoma Anemarrhenae 5-12 gram Cortex Phellodendri 8-15 gram

Be preferably: Fructus Rosae Laevigatae 20 grams, Semen Plantaginis 20 grams, Semen Caesalpiniae Minacis 30 grams, Rhizoma Osmundae 20 grams, Rhizoma Belamcandae 20 gram, Rhizoma Dioscoreae Septemlobae 20 grams, Radix Rehmanniae Preparata 20 grams, Rhizoma Dioscoreae 20 grams, Radix Angelicae Sinensis 15 grams, Semen Euryales 20 grams, the Rhizoma Anemarrhenae 10 grams, Cortex Phellodendri 10 grams.

The preparation method of medicine of the present invention is as follows:

One, gets the raw materials ready

1, Fructus Rosae Laevigatae: choose decontamination, cut two lobes, water is washed bubble slightly, pulls out, removes residual burr behind the moistening, digs clean hair, nuclear, drying;

2, Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;

3, Semen Caesalpiniae Minacis: remove impurity, cleaning, drying;

4, Rhizoma Osmundae: soak slightly with clear water, take out, each watering is sooner or later once moistened softly, and section is dried;

5, Rhizoma Belamcandae: choose decontamination, washing is soaked only slightly, pulls out, runs through, and section is dried, and sieve goes and must, consider to be worth doing;

6,, Rhizoma Dioscoreae Septemlobae: autumn, two seasons of winter take rhizome, remove fibrous root, remove clean earth, and section is dried;

7, Radix Rehmanniae Preparata: get crude drug, steam, take out, when solarization is done to about eighty per cant, cut sheet or piece, drying to surperficial corvinus;

8, Rhizoma Dioscoreae: choose decontamination, be soaked in water and pull out and dry in the air slightly for degree to the Rhizoma Dioscoreae central part is softening, section is dried or is dried;

9, Radix Angelicae Sinensis: choose decontamination, clean, moistening dries in the air slightly to inside and outside humidity when suitable, and section is dried;

10, Semen Euryales: choose decontamination, dry;

11, the Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, moistens softly, and section is dried;

12, Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding are dried.

Two, preparation:

By measuring pure gold cherry, Semen Plantaginis, Semen Caesalpiniae Minacis, Rhizoma Osmundae, Rhizoma Belamcandae, Rhizoma Dioscoreae Septemlobae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Radix Angelicae Sinensis, Semen Euryales, the Rhizoma Anemarrhenae, Cortex Phellodendri, adding water 600 grams-700 grams soaked after 20 minutes, decoct with high heat, after the medicinal liquid boiling, change by slow fire boiling 15-20 minute, decoct after-filtration, get its medicinal liquid.

When secondary decocts, add water 500 grams, decoct boiling back slow fire boiling 15 minutes, cross its medicinal liquid of leaching.

Medicine of the present invention is a secret prescription handed down in the family from generation to generation, and repeatedly tests in clinical application, has clearing away heat-damp and promoting diuresis, divides Qinghua turbid effect.It is fast to be used for the treatment of the chyluria curative effect, the cure rate height.

The specific embodiment:

Below further set forth the beneficial effect of medicine of the present invention by testing example.

[test example 1] animal experiment report:

Get New Zealand man and exempt from 20, the male and female dual-purpose, body weight 2.0-2.5kg is divided into two groups, and 10 every group, wherein one group is the normal amount toxicity test, and another group is the excess toxicity test.

The normal amount toxicity test: get the said medicine oral liquid, administering mode is a gastric infusion, and once a day, each consumption 10ml continuous 7 days, observes 10 all no abnormal reactions of rabbit every day.

The excess toxicity test: get the above-mentioned medicine oral liquid for preparing, 10 rabbit of gastric infusion, every day secondary, each consumption is 30ml, logotype 7 days there is no abnormal response.

Evidence, medicine of the present invention has no side effect.

The clinical observation of [test example 2] Drug therapy chyluria of the present invention

1, physical data

Accept out-patient's totally 178 examples for medical treatment, wherein male 82 examples, women 96 examples, age 35-45 year 35 examples wherein, 46-50 year 78 examples, 51-60 year 34 examples, 31 examples more than 60 years old.

2, diagnostic criteria

Chyluria shows as that urine is creamy white or color of soy sauce, or is mingled with the chyle grumeleuse, leaves standstill back come-up fat and drips.Be intermittent attack, severe patient can be persistence more, continues features such as a couple of days or several weeks at every turn.

3, Therapeutic Method

The oral medicine oral liquid of the present invention of secondary every day, each 200ml, 7 days is a course of treatment, serveing on two courses of treatment can cure.

4, efficacy assessment standard

Produce effects: chyluria is after treatment, and it is clear that urine is changeed, and the naked eyes chyle disappears, and observes 1 year no recidivist.

Take a turn for the better: chyluria is after treatment, and the muddy situation of urine becomes clearly gradually, in one month rebound phenomenon is arranged, add a course of treatment after, observe 1 year no recidivist.

Invalid: as not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, with Drug therapy chyluria patient 178 examples of the present invention, produce effects 154 examples as a result, obvious effective rate is 86.52%, 22 examples that take a turn for the better, improvement rate is 12.36%, invalid 2 examples, total effective rate is 98.88%.

Claims (3)

1. medicine for the treatment of chyluria, it is characterized in that: it is to be made by the crude drug in the following weight range:

Fructus Rosae Laevigatae 15-25 gram Semen Plantaginis 15-25 gram Semen Caesalpiniae Minacis 25-35 gram

Rhizoma Osmundae 15-20 gram Rhizoma Belamcandae 18-22 Ke Rhizoma Dioscoreae Septemlobae 15-25 gram

Radix Rehmanniae Preparata 18-25 Keshan medicine 14-22 gram Radix Angelicae Sinensis 10-20 gram

Semen Euryales 15-22 gram Rhizoma Anemarrhenae 5-12 gram Cortex Phellodendri 8-15 gram.

2. medicine according to claim 1, wherein the consumption of each raw material is: Fructus Rosae Laevigatae 20 grams, Semen Plantaginis 20 grams, Semen Caesalpiniae Minacis 30 grams, Rhizoma Osmundae 20 grams, Rhizoma Belamcandae 20 gram, Rhizoma Dioscoreae Septemlobae 20 grams, Radix Rehmanniae Preparata 20 grams, Rhizoma Dioscoreae 20 grams, Radix Angelicae Sinensis 15 grams, Semen Euryales 20 grams, the Rhizoma Anemarrhenae 10 grams, Cortex Phellodendri 10 grams.

3. according to the preparation method of claim 1 or 2 described medicines, comprise the following steps:

(1) gets the raw materials ready

(1) Fructus Rosae Laevigatae: choose decontamination, cut two lobes, water is washed bubble slightly, pulls out, removes residual burr behind the moistening, digs clean hair, nuclear, drying;

(2) Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;

(3) Semen Caesalpiniae Minacis: remove impurity, cleaning, drying;

(4) Rhizoma Osmundae: soak slightly with clear water, take out, each watering is sooner or later once moistened softly, and section is dried;

(5) Rhizoma Belamcandae: choose decontamination, washing is soaked only slightly, pulls out, runs through, and section is dried, and sieve goes and must, consider to be worth doing;

(6) Rhizoma Dioscoreae Septemlobae: autumn, two seasons of winter take rhizome, remove fibrous root, remove clean earth, and section is dried;

(7) Radix Rehmanniae Preparata: get crude drug, steam, take out, shine when eighty per cant does, cut sheet or piece, drying to surperficial corvinus;

(8) Rhizoma Dioscoreae: choose decontamination, be soaked in water and pull out and dry in the air slightly for degree to the Rhizoma Dioscoreae central part is softening, section is dried or is dried;

(9) Radix Angelicae Sinensis: choose decontamination, clean, moistening dries in the air slightly to inside and outside humidity when suitable, and section is dried;

(10) Semen Euryales: choose decontamination, dry;

(11) Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, moistens softly, and section is dried;

(12) Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding are dried;

(2) preparation:

By measuring pure gold cherry, Semen Plantaginis, Semen Caesalpiniae Minacis, Rhizoma Osmundae, Rhizoma Belamcandae, Rhizoma Dioscoreae Septemlobae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Radix Angelicae Sinensis, Semen Euryales, the Rhizoma Anemarrhenae, Cortex Phellodendri, adding water 600 grams-700 grams soaked after 20 minutes, decoct with high heat, after the medicinal liquid boiling, change by slow fire boiling 15-20 minute, decoct after-filtration, get its medicinal liquid.