CN113975359B - Pharmaceutical composition and preparation method and application thereof - Google Patents
Pharmaceutical composition and preparation method and application thereof Download PDFInfo
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- CN113975359B CN113975359B CN202111098718.5A CN202111098718A CN113975359B CN 113975359 B CN113975359 B CN 113975359B CN 202111098718 A CN202111098718 A CN 202111098718A CN 113975359 B CN113975359 B CN 113975359B
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a pharmaceutical composition, a preparation method and application thereof. The pharmaceutical composition consists of the following bulk drugs in the weight range: 4-10 g of glutinous rice root, 4-10 g of yam rhizome, 2-6 g of amur corktree bark, 4-8 g of plantain seed, 3-7 g of Chinese angelica, 2-6 g of combined spicebush root, 1-4 g of fructus alpiniae oxyphyllae and 1-5 g of grassleaf sweelflag rhizome. The pharmaceutical composition disclosed by the invention can be used for treating chyluria patients, and can be used for effectively relieving or eliminating the turbid urine symptoms of chyluria patients.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a pharmaceutical composition, a preparation method thereof and application thereof in treating chyluria or lymphangitis.
Background
Chyluria (chyluria) is a disease of lymphatic vessels, chyluria is formed by countercurrent flow of chyluria into urine, and has different degrees of milky white appearance, and can be positive in urine chyluria test. If more blood is contained, it is called chyluria. Chyluria is characterized by turbid urine such as milk, or swill-like, soybean milk, so it is called. Chyluria is highest at the age of 30-60 years. The pathogenesis of chyluria is currently considered as obstruction of chest ducts, local lymphatic vessel inflammation damage, change of lymphatic dynamics, and the entrance of lymphatic fluid into urinary tract to generate chyluria. Chyluria is classified as mild, moderate, and severe according to severity. Mild manifestations of intermittent chyluria, no formation of chyluria clots, no weight loss.
The lymph leakage is usually caused by operation related injury, the lymph circulation path is destroyed or interrupted, the lymph pressure at the destroyed part is larger than the pressure in the tissue or the pressure in the body cavity, and the lymph flows out to form the lymph leakage.
The Western medicines have poor effect of treating chyluria and lymphadenitis at present and have more side effects. Therefore, there is a need to provide a traditional Chinese medicine formula for treating chyluria and lymphadenitis.
Disclosure of Invention
The invention provides a pharmaceutical composition capable of effectively treating chyluria and lymphangitis according to the research and clinical test and verification of traditional Chinese medicine theory.
The invention aims to provide a pharmaceutical composition for treating chyluria or lymphangitis.
The invention provides a pharmaceutical composition which comprises the following raw materials in parts by weight: 4-10 g of glutinous rice root, 4-10 g of yam rhizome, 2-6 g of amur corktree bark, 4-8 g of plantain seed, 3-7 g of Chinese angelica, 2-6 g of combined spicebush root, 1-4 g of fructus alpiniae oxyphyllae and 1-5 g of grassleaf sweelflag rhizome.
Further, the pharmaceutical composition comprises the following bulk drugs in the weight range: 5-9 g of glutinous rice root, 5-9 g of yam rhizome, 3-5 g of amur corktree bark, 5-7 g of plantain seed, 4-6 g of Chinese angelica, 3-5 g of combined spicebush root, 2-3 g of fructus alpiniae oxyphyllae and 2-4 g of grassleaf sweelflag rhizome.
Further, the pharmaceutical composition comprises the following bulk drugs in the weight range: 6 g of glutinous rice root, 6 g of yam rhizome, 4 g of amur corktree bark, 6 g of plantain seed, 5 g of Chinese angelica, 4 g of combined spicebush root, 2 g of fructus alpiniae oxyphyllae and 3 g of grassleaf sweelflag rhizome.
It is another object of the present invention to provide a method for preparing a pharmaceutical composition.
The invention provides a preparation method of a pharmaceutical composition, which comprises the following steps:
s1, preparing materials:
glutinous rice root: taking the raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, and drying in the initial stage;
rhizoma Dioscoreae Septemlobae: taking raw materials, removing fibrous roots, removing soil, slicing and sun drying;
cortex Phellodendri: removing impurities, spraying clear water, moistening thoroughly, slicing or shredding, and sun drying;
semen plantaginis: removing impurities, sieving to remove mud and dust, and granulating;
chinese angelica root: removing impurities, cleaning, moistening, slightly airing to a proper internal and external humidity, slicing and airing;
lindera root: removing fine roots, cleaning, slicing while fresh, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
rhizoma Acori Graminei: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking glutinous rice root, yam rhizome, amur corktree bark, plantain seed, chinese angelica, combined spicebush root, sharpleaf galangal fruit and grassleaf sweelflag rhizome according to the weight, adding 4-6 times of water, decocting for 1.5-2 hours, and filtering to obtain liquid medicine.
It is another object of the present invention to provide a pharmaceutical formulation formed using the pharmaceutical composition described above.
Further, the pharmaceutical preparation is selected from one of powder, granule, tablet, capsule, solution and suspension.
It is another object of the present invention to provide the use of a pharmaceutical composition for the manufacture of a medicament for the treatment of chyluria or post-operative lymphorrhea.
The invention provides an application of a pharmaceutical composition in treating chyluria or postoperative lymphangitis.
Further, the pharmaceutical composition is administered twice daily, wherein the single administration dose is the pharmaceutical composition and the dose thereof as described above.
The glutinous rice root disclosed by the invention is sweet in taste; sex level; enter liver meridian; is mainly used for treating fever due to yin deficiency, spontaneous perspiration, night sweat, thirst, dry throat, hepatitis and filariasis; has effects of nourishing yin, removing heat, and inhibiting sweat.
The yam rhizome of the present invention has bitter taste and flat nature. Enter liver, stomach and bladder meridians. Has effects of promoting diuresis, treating stranguria, and dispelling pathogenic wind and dampness. Clinically, the traditional Chinese medicine composition is used for treating symptoms such as stranguria caused by plaster, leucorrhea and the like. Dioscorea septemloba can promote diuresis and separate clear and turbid urine, and is an essential medicine for treating stranguria caused by damp-turbid stagnation of lower-jiao; for leukorrhagia due to damp-purgation, it is combined with Fu Ling and Bai Zhu, etc.
The phellodendron bark of the invention has bitter and cold nature; kidney, bladder and large intestine channels; has effects of clearing heat, eliminating dampness, purging pathogenic fire, and removing toxic substances; can be used for treating damp-heat dysentery, jaundice, leukorrhagia, stranguria due to heat, tinea pedis, flaccidity, bone steaming, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, and eczema and pruritus.
The plantain seed of the invention has sweet taste and slightly cold property; the liver, kidney, lung and small intestine channels; has effects of clearing heat, promoting urination, removing dampness, treating stranguria, improving eyesight, and eliminating phlegm; can be used for treating swelling and pain of water, stranguria due to heat, diarrhea due to summer-heat and dampness, conjunctival congestion, swelling and pain, and cough due to phlegm-heat.
The Chinese angelica is warm in nature, sweet and spicy; enter liver, heart and spleen meridians; has effects in replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. Can be used for treating sallow complexion due to blood deficiency, dizziness, palpitation, menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency-cold, constipation due to intestinal dryness, rheumatalgia, traumatic injury, carbuncle, and pyocutaneous disease.
The combined spicebush root disclosed by the invention is spicy and warm in nature; the Chinese medicinal composition enters lung, spleen, kidney and bladder channels; has effects in activating qi-flowing, relieving pain, warming kidney, and dispelling cold; can be used for treating chest and abdominal distention and pain, dyspnea and urgent, bladder deficiency and cold, enuresis, frequent urination, hernia, and dysmenorrhea.
The fructus alpiniae oxyphyllae of the invention has warm nature and pungent taste; spleen channel and kidney channel; has effects in warming spleen, relieving diarrhea, controlling salivary flow, warming kidney, and stopping nocturnal emission and urination; can be used for treating diarrhea due to cold in spleen, cold pain in abdomen, excessive saliva and saliva, enuresis due to kidney deficiency, frequent urination, spermatorrhea, and turbid urine.
The grassleaf sweelflag rhizome disclosed by the invention is spicy and warm in nature; return to heart and stomach meridians; has effects of eliminating dampness, stimulating appetite, inducing resuscitation, eliminating phlegm, refreshing mind, and improving intelligence; can be used for treating gastric fullness, hunger, vomiting, dysentery, unconsciousness, epilepsy, amnesia, and deafness.
The invention has the beneficial effects that:
the medicinal composition adopts the traditional Chinese medicines such as glutinous rice roots, yam rhizome, amur corktree barks, plantain seeds, chinese angelica, combined spicebush roots, fructus alpiniae oxyphyllae, grassleaf sweelflag rhizome and the like, and the combination of the traditional Chinese medicines enables the effects of the traditional Chinese medicines to generate a synergistic effect, so that chyluria and lymphadenitis can be effectively treated. The medicine composition disclosed by the invention takes glutinous rice roots and yam rhizome as main components, reduces turbid urine, and simultaneously, cortex phellodendri, semen plantaginis, angelica sinensis, combined spicebush root, fructus alpiniae oxyphyllae, grassleaf sweelflag rhizome and glutinous rice roots and yam rhizome are added for use together, so that the medicine composition has an excellent treatment effect on chyluria and lymphadenitis.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely, and it is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to fall within the scope of the invention.
The embodiment of the invention provides a pharmaceutical composition, and a preparation method and application thereof. Each of which is described in detail below. The following description of the embodiments is not intended to limit the preferred embodiments. In addition, in the description of the present invention, the term "comprising" means "including but not limited to". Various embodiments of the invention may exist in a range of forms; it should be understood that the description in a range format is merely for convenience and brevity and should not be construed as a rigid limitation on the scope of the invention; it is therefore to be understood that the range description has specifically disclosed all possible sub-ranges and individual values within that range. For example, it should be considered that a description of a range from 1 to 6 has specifically disclosed sub-ranges, such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as single numbers within the ranges, such as 1, 2, 3, 4, 5, and 6, wherever applicable. In addition, whenever a numerical range is referred to herein, it is meant to include any reference number (fractional or integer) within the indicated range.
The embodiment of the invention provides a pharmaceutical composition which can be used for treating chyluria or lymphadenitis. The medicine composition consists of the following raw materials in the weight range: 4-10 g of glutinous rice root, 4-10 g of yam rhizome, 2-6 g of amur corktree bark, 4-8 g of plantain seed, 3-7 g of Chinese angelica, 2-6 g of combined spicebush root, 1-4 g of fructus alpiniae oxyphyllae and 1-5 g of grassleaf sweelflag rhizome.
Further, in the pharmaceutical composition, the glutinous rice root may have a weight of 4 g, 5 g, 6 g, 7 g, 8 g, 9 g or 10 g; the weight of the yam rhizome can be 4 g, 5 g, 6 g, 7 g, 8 g, 9 g or 10 g; the weight of the phellodendron can be 2 g, 3 g, 4 g, 5 g or 6 g; the weight of the plantain seed can be 4 g, 5 g, 6 g, 7 g and 8 g; the weight of the angelica can be 3 g, 4 g, 5 g, 6 g or 7 g; the combined spicebush root can be 2 g, 3 g, 4 g, 5 g or 6 g in weight; the weight of the fructus alpiniae oxyphyllae can be 1 gram, 2 grams, 3 grams or 4 grams; the weight of the grassleaf sweelflag rhizome can be 1 gram, 2 grams, 3 grams, 4 grams or 5 grams.
The preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking the raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, and drying in the initial stage;
rhizoma Dioscoreae Septemlobae: taking raw materials, removing fibrous roots, removing soil, slicing and sun drying;
cortex Phellodendri: removing impurities, spraying clear water, moistening thoroughly, slicing or shredding, and sun drying;
semen plantaginis: removing impurities, sieving to remove mud and dust, and granulating;
chinese angelica root: removing impurities, cleaning, moistening, slightly airing to a proper internal and external humidity, slicing and airing;
lindera root: removing fine roots, cleaning, slicing while fresh, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
rhizoma Acori Graminei: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking glutinous rice root, yam rhizome, amur corktree bark, plantain seed, chinese angelica, combined spicebush root, sharpleaf galangal fruit and grassleaf sweelflag rhizome according to the weight, adding 4-6 times of water, decocting for 1.5-2 hours, and filtering to obtain liquid medicine.
The invention can form various pharmaceutical preparations by adopting the pharmaceutical composition; further, the pharmaceutical preparation may be one of powder, granule, tablet, capsule, solution and suspension. In practical application, the pharmaceutical composition can be prepared into a certain dosage form suitable for use according to specific needs.
The pharmaceutical composition can be applied to medicines for treating chyluria or post-operative lymphangitis. Further, the pharmaceutical composition is administered twice daily, wherein the single dose is the pharmaceutical composition and the dose thereof as described above. That is, the pharmaceutical composition is used in a single dose amount of: 4-10 g of glutinous rice root, 4-10 g of yam rhizome, 2-6 g of amur corktree bark, 4-8 g of plantain seed, 3-7 g of Chinese angelica, 2-6 g of combined spicebush root, 1-4 g of fructus alpiniae oxyphyllae and 1-5 g of grassleaf sweelflag rhizome.
The invention has been tested several times in succession, and a detailed description of the invention will now be given with reference to a portion of the test results, with the following detailed description being given in connection with specific examples.
Example 1
The embodiment provides a pharmaceutical composition, which consists of the following bulk drugs in the weight range: 10 g of glutinous rice root, 4 g of yam rhizome, 6 g of amur corktree bark, 4 g of plantain seed, 7 g of Chinese angelica, 2 g of combined spicebush root, 4 g of fructus alpiniae oxyphyllae and 1 g of rhizoma acori graminei.
The preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking the raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, and drying in the initial stage;
rhizoma Dioscoreae Septemlobae: taking raw materials, removing fibrous roots, removing soil, slicing and sun drying;
cortex Phellodendri: removing impurities, spraying clear water, moistening thoroughly, slicing or shredding, and sun drying;
semen plantaginis: removing impurities, sieving to remove mud and dust, and granulating;
chinese angelica root: removing impurities, cleaning, moistening, slightly airing to a proper internal and external humidity, slicing and airing;
lindera root: removing fine roots, cleaning, slicing while fresh, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
rhizoma Acori Graminei: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking glutinous rice root, yam rhizome, amur corktree bark, plantain seed, chinese angelica, combined spicebush root, sharpleaf galangal fruit and grassleaf sweelflag rhizome according to the weight, adding 6 times of water, decocting for 2 hours, and filtering to obtain liquid medicine.
Example 2
The embodiment provides a pharmaceutical composition, which consists of the following bulk drugs in the weight range: 4 g of glutinous rice root, 10 g of yam rhizome, 2 g of amur corktree bark, 8 g of plantain seed, 3 g of Chinese angelica, 6 g of combined spicebush root, 1 g of fructus alpiniae oxyphyllae and 5 g of rhizoma acori graminei.
The preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking the raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, and drying in the initial stage;
rhizoma Dioscoreae Septemlobae: taking raw materials, removing fibrous roots, removing soil, slicing and sun drying;
cortex Phellodendri: removing impurities, spraying clear water, moistening thoroughly, slicing or shredding, and sun drying;
semen plantaginis: removing impurities, sieving to remove mud and dust, and granulating;
chinese angelica root: removing impurities, cleaning, moistening, slightly airing to a proper internal and external humidity, slicing and airing;
lindera root: removing fine roots, cleaning, slicing while fresh, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
rhizoma Acori Graminei: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking glutinous rice root, yam rhizome, amur corktree bark, plantain seed, chinese angelica, combined spicebush root, sharpleaf galangal fruit and grassleaf sweelflag rhizome according to the weight, adding 4 times of water, decocting for 1.5 hours, and filtering to obtain a liquid medicine.
Example 3
The embodiment provides a pharmaceutical composition, which consists of the following bulk drugs in the weight range: 9 g of glutinous rice root, 5 g of yam rhizome, 5 g of amur corktree bark, 5 g of plantain seed, 6 g of Chinese angelica, 3 g of combined spicebush root, 3 g of fructus alpiniae oxyphyllae and 2 g of rhizoma acori graminei.
The preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking the raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, and drying in the initial stage;
rhizoma Dioscoreae Septemlobae: taking raw materials, removing fibrous roots, removing soil, slicing and sun drying;
cortex Phellodendri: removing impurities, spraying clear water, moistening thoroughly, slicing or shredding, and sun drying;
semen plantaginis: removing impurities, sieving to remove mud and dust, and granulating;
chinese angelica root: removing impurities, cleaning, moistening, slightly airing to a proper internal and external humidity, slicing and airing;
lindera root: removing fine roots, cleaning, slicing while fresh, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
rhizoma Acori Graminei: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking glutinous rice root, yam rhizome, amur corktree bark, plantain seed, chinese angelica, combined spicebush root, sharpleaf galangal fruit and grassleaf sweelflag rhizome according to the weight, adding 6 times of water, decocting for 1.5 hours, and filtering to obtain a liquid medicine.
Example 4
The embodiment provides a pharmaceutical composition, which consists of the following bulk drugs in the weight range: 5 g of glutinous rice root, 9 g of yam rhizome, 3 g of amur corktree bark, 7 g of plantain seed, 4 g of Chinese angelica, 5 g of combined spicebush root, 2 g of fructus alpiniae oxyphyllae and 4 g of rhizoma acori graminei.
The preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking the raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, and drying in the initial stage;
rhizoma Dioscoreae Septemlobae: taking raw materials, removing fibrous roots, removing soil, slicing and sun drying;
cortex Phellodendri: removing impurities, spraying clear water, moistening thoroughly, slicing or shredding, and sun drying;
semen plantaginis: removing impurities, sieving to remove mud and dust, and granulating;
chinese angelica root: removing impurities, cleaning, moistening, slightly airing to a proper internal and external humidity, slicing and airing;
lindera root: removing fine roots, cleaning, slicing while fresh, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
rhizoma Acori Graminei: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking glutinous rice root, yam rhizome, amur corktree bark, plantain seed, chinese angelica, combined spicebush root, sharpleaf galangal fruit and grassleaf sweelflag rhizome according to the weight, adding 4 times of water, decocting for 2 hours, and filtering to obtain liquid medicine.
Example 5
The embodiment provides a pharmaceutical composition, which consists of the following bulk drugs in the weight range: 6 g of glutinous rice root, 6 g of yam rhizome, 4 g of amur corktree bark, 6 g of plantain seed, 5 g of Chinese angelica, 4 g of combined spicebush root, 2 g of fructus alpiniae oxyphyllae and 3 g of rhizoma acori graminei.
The preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking the raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, and drying in the initial stage;
rhizoma Dioscoreae Septemlobae: taking raw materials, removing fibrous roots, removing soil, slicing and sun drying;
cortex Phellodendri: removing impurities, spraying clear water, moistening thoroughly, slicing or shredding, and sun drying;
semen plantaginis: removing impurities, sieving to remove mud and dust, and granulating;
chinese angelica root: removing impurities, cleaning, moistening, slightly airing to a proper internal and external humidity, slicing and airing;
lindera root: removing fine roots, cleaning, slicing while fresh, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
rhizoma Acori Graminei: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking glutinous rice root, yam rhizome, amur corktree bark, plantain seed, chinese angelica, combined spicebush root, sharpleaf galangal fruit and grassleaf sweelflag rhizome according to the weight, adding 5 times of water, decocting for 2 hours, and filtering to obtain liquid medicine.
Test example 1
The test examples were carried out on chyluria patients using the pharmaceutical compositions of examples 1 to 5, and the results of the treatment were recorded and are shown in Table 1.
The treatment method comprises the following steps: the medicine liquid prepared by the medicine composition in the examples 1-5 is used for respectively treating 66 cases of chyluria patients, the medicine taking mode is twice daily, oral administration is carried out, the treatment time is 28 days, and the patients with obvious effects are continuously observed for 6 months; wherein the dose in example 5 is a single administration dose.
Efficacy assessment criteria: the effect is shown: the urine color changes clear after treatment, and no obvious recurrence exists within 6 months; improvement: the urine color is obviously changed to clear, and turbid urine is sometimes used; invalidation: the turbid urine is not obviously improved.
Treatment results:
TABLE 1
According to the test example, the medicine composition of each embodiment of the invention is used for treating 66 chyluria patients, the total effective rate is up to 96.97%, and the beneficial effect is obvious. For example, treatment of chyluria patients with the pharmaceutical composition of example 5 resulted in: 26 cases of obvious effect, the obvious effect efficiency is 39.39%; 38 cases are improved, and the improvement efficiency is 57.58%; 2 cases were not used, and the inefficiency was 3.03%. The total effective rate of the pharmaceutical composition of the invention reaches 96.97%.
In summary, the pharmaceutical composition of the present invention is capable of treating a chyluria patient, which is effective in alleviating or eliminating symptoms in a chyluria patient.
The above description of the pharmaceutical composition, the preparation method and the application thereof provided by the embodiment of the present invention has been presented in detail, and specific examples are applied herein to illustrate the principles and embodiments of the present invention, and the above examples are only used to help understand the method and core idea of the present invention; meanwhile, as those skilled in the art will have variations in the specific embodiments and application scope in light of the ideas of the present invention, the present description should not be construed as limiting the present invention.
Claims (5)
1. The pharmaceutical composition for treating chyluria is characterized by being prepared from the following raw materials in parts by weight:
5-9 g of glutinous rice root, 5-9 g of yam rhizome, 3-5 g of amur corktree bark, 5-7 g of plantain seed, 4-6 g of Chinese angelica, 3-5 g of combined spicebush root, 2-3 g of fructus alpiniae oxyphyllae and 2-4 g of grassleaf sweelflag rhizome;
the preparation method of the pharmaceutical composition comprises the following steps:
s1, preparing materials:
glutinous rice root: taking the raw medicinal materials, removing impurities and residual stems, cleaning, taking out, draining, and drying in the initial stage;
rhizoma Dioscoreae Septemlobae: taking raw materials, removing fibrous roots, removing soil, slicing and sun drying;
cortex Phellodendri: removing impurities, spraying clear water, moistening thoroughly, slicing or shredding, and sun drying;
semen plantaginis: removing impurities, sieving to remove mud and dust, and granulating;
chinese angelica root: removing impurities, cleaning, moistening, slightly airing to a proper internal and external humidity, slicing and airing;
lindera root: removing fine roots, cleaning, slicing while fresh, and sun drying;
fructus alpiniae oxyphyllae: removing impurities and shell, and mashing;
rhizoma Acori Graminei: removing impurities, cleaning, moistening, slicing, and sun drying;
s2, preparation:
taking glutinous rice root, yam rhizome, amur corktree bark, plantain seed, chinese angelica, combined spicebush root, sharpleaf galangal fruit and grassleaf sweelflag rhizome according to the weight, adding 4-6 times of water, decocting for 1.5-2 hours, and filtering to obtain liquid medicine.
2. The pharmaceutical composition for treating chyluria according to claim 1, wherein the pharmaceutical composition is prepared from the following raw materials in the weight range: 6 g of glutinous rice root, 6 g of yam rhizome, 4 g of amur corktree bark, 6 g of plantain seed, 5 g of Chinese angelica, 4 g of combined spicebush root, 2 g of fructus alpiniae oxyphyllae and 3 g of grassleaf sweelflag rhizome.
3. A pharmaceutical formulation formed using the pharmaceutical composition for treating chyluria according to any one of claims 1 to 2.
4. A pharmaceutical formulation according to claim 3, wherein the pharmaceutical formulation is selected from one of a powder, a granule, a tablet, a capsule, a solution and a suspension.
5. Use of a pharmaceutical composition according to any one of claims 1 to 2 for the treatment of chyluria in the manufacture of a medicament for the treatment of chyluria.
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