WO2018021891A1 - Composition containing natural material extract as active ingredient for alleviating constipation and coprostasis and preparation method therefor - Google Patents
Composition containing natural material extract as active ingredient for alleviating constipation and coprostasis and preparation method therefor Download PDFInfo
- Publication number
- WO2018021891A1 WO2018021891A1 PCT/KR2017/008207 KR2017008207W WO2018021891A1 WO 2018021891 A1 WO2018021891 A1 WO 2018021891A1 KR 2017008207 W KR2017008207 W KR 2017008207W WO 2018021891 A1 WO2018021891 A1 WO 2018021891A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- natural material
- weight
- constipation
- composition
- natural
- Prior art date
Links
- 239000005445 natural material Substances 0.000 title claims abstract description 89
- 239000000203 mixture Substances 0.000 title claims abstract description 74
- 206010010774 Constipation Diseases 0.000 title claims abstract description 68
- 239000000284 extract Substances 0.000 title claims abstract description 46
- 239000004480 active ingredient Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title abstract description 14
- 206010056325 Faecaloma Diseases 0.000 title abstract 6
- 239000000843 powder Substances 0.000 claims abstract description 31
- 235000004426 flaxseed Nutrition 0.000 claims abstract description 27
- 235000004431 Linum usitatissimum Nutrition 0.000 claims abstract description 21
- 240000006240 Linum usitatissimum Species 0.000 claims abstract description 18
- 239000008187 granular material Substances 0.000 claims abstract description 12
- 239000006187 pill Substances 0.000 claims abstract description 12
- 241001474374 Blennius Species 0.000 claims description 28
- 230000006872 improvement Effects 0.000 claims description 20
- 239000012141 concentrate Substances 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 235000013305 food Nutrition 0.000 claims description 13
- 239000004615 ingredient Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000008213 purified water Substances 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 238000012856 packing Methods 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
- 240000008042 Zea mays Species 0.000 claims description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 4
- 235000005822 corn Nutrition 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 4
- 240000007594 Oryza sativa Species 0.000 claims description 3
- 235000007164 Oryza sativa Nutrition 0.000 claims description 3
- 201000010041 presbyopia Diseases 0.000 claims description 3
- 235000009566 rice Nutrition 0.000 claims description 3
- 235000008504 concentrate Nutrition 0.000 claims 5
- 235000014483 powder concentrate Nutrition 0.000 claims 1
- 238000009700 powder processing Methods 0.000 claims 1
- 239000004460 silage Substances 0.000 claims 1
- 241001116389 Aloe Species 0.000 abstract 1
- 241000218236 Cannabis Species 0.000 abstract 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 abstract 1
- 235000011399 aloe vera Nutrition 0.000 abstract 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 abstract 1
- 210000000582 semen Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 41
- 210000002784 stomach Anatomy 0.000 description 14
- 206010012735 Diarrhoea Diseases 0.000 description 11
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 10
- 208000004998 Abdominal Pain Diseases 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 235000013325 dietary fiber Nutrition 0.000 description 8
- MJYQFWSXKFLTAY-OVEQLNGDSA-N (2r,3r)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butane-1,4-diol;(2r,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O.C1=C(O)C(OC)=CC(C[C@@H](CO)[C@H](CO)CC=2C=C(OC)C(O)=CC=2)=C1 MJYQFWSXKFLTAY-OVEQLNGDSA-N 0.000 description 7
- 244000068988 Glycine max Species 0.000 description 7
- 235000010469 Glycine max Nutrition 0.000 description 7
- 230000001882 diuretic effect Effects 0.000 description 7
- 229910001385 heavy metal Inorganic materials 0.000 description 7
- 206010019233 Headaches Diseases 0.000 description 6
- 206010047700 Vomiting Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 231100000869 headache Toxicity 0.000 description 6
- 230000001788 irregular Effects 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 238000005728 strengthening Methods 0.000 description 6
- 230000008673 vomiting Effects 0.000 description 6
- 229910001868 water Inorganic materials 0.000 description 6
- 230000004580 weight loss Effects 0.000 description 6
- 206010000059 abdominal discomfort Diseases 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 230000036772 blood pressure Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 5
- 210000000936 intestine Anatomy 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- 241000208202 Linaceae Species 0.000 description 4
- 208000004880 Polyuria Diseases 0.000 description 4
- 229910052785 arsenic Inorganic materials 0.000 description 4
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000037406 food intake Effects 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 210000002429 large intestine Anatomy 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000002341 toxic gas Substances 0.000 description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000001093 anti-cancer Effects 0.000 description 3
- 230000013872 defecation Effects 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- 239000011630 iodine Substances 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 230000008447 perception Effects 0.000 description 3
- 230000008855 peristalsis Effects 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- 239000001606 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one Substances 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 241000675108 Citrus tangerina Species 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 2
- 235000011613 Pinus brutia Nutrition 0.000 description 2
- 241000018646 Pinus brutia Species 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010042674 Swelling Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000783 alginic acid Substances 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 229960001126 alginic acid Drugs 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 235000021152 breakfast Nutrition 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 229930013686 lignan Natural products 0.000 description 2
- 235000009408 lignans Nutrition 0.000 description 2
- 150000005692 lignans Chemical class 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 description 2
- 229940052490 naringin Drugs 0.000 description 2
- 229930019673 naringin Natural products 0.000 description 2
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 208000020016 psychiatric disease Diseases 0.000 description 2
- 230000008085 renal dysfunction Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 239000005495 thyroid hormone Substances 0.000 description 2
- 229940036555 thyroid hormone Drugs 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
- 210000004291 uterus Anatomy 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 208000016261 weight loss Diseases 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000084 Abdominal pain lower Diseases 0.000 description 1
- 241000486679 Antitype Species 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 241000512259 Ascophyllum nodosum Species 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 description 1
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010013554 Diverticulum Diseases 0.000 description 1
- 208000030814 Eating disease Diseases 0.000 description 1
- 241000946389 Ecklonia kurome Species 0.000 description 1
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000019454 Feeding and Eating disease Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 206010018498 Goitre Diseases 0.000 description 1
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 description 1
- 241001559542 Hippocampus hippocampus Species 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 241000218231 Moraceae Species 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 235000019057 Raphanus caudatus Nutrition 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000011380 Raphanus sativus Nutrition 0.000 description 1
- 241000015177 Saccharina japonica Species 0.000 description 1
- 241000220690 Sargassum pallidum Species 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000024799 Thyroid disease Diseases 0.000 description 1
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 230000002790 anti-mutagenic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000003925 brain function Effects 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 235000019577 caloric intake Nutrition 0.000 description 1
- 235000009120 camo Nutrition 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000005607 chanvre indien Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- APSNPMVGBGZYAJ-GLOOOPAXSA-N clematine Natural products COc1cc(ccc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 APSNPMVGBGZYAJ-GLOOOPAXSA-N 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 235000014632 disordered eating Nutrition 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000005686 eating Nutrition 0.000 description 1
- 230000007937 eating Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 235000021197 fiber intake Nutrition 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 201000003872 goiter Diseases 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 239000011487 hemp Substances 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 229940025878 hesperidin Drugs 0.000 description 1
- VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 description 1
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 description 1
- -1 heterocyclic amines Chemical class 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 208000003532 hypothyroidism Diseases 0.000 description 1
- 230000002989 hypothyroidism Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- ARGKVCXINMKCAZ-UZRWAPQLSA-N neohesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@H](O)[C@@H](O)[C@H](C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UZRWAPQLSA-N 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229960002969 oleic acid Drugs 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 235000017802 other dietary supplement Nutrition 0.000 description 1
- 235000020830 overeating Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001175 peptic effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 231100000046 skin rash Toxicity 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 235000019614 sour taste Nutrition 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 208000021510 thyroid gland disease Diseases 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
Definitions
- the present invention relates to a composition for improving constipation and stool with natural ingredients as an active ingredient, and a method for producing the same, and in detail, cha jeonpi, innerwear, seaweed, packing, baekbokyeong, presbytery, jisil, crust, baekchul, linseed and
- the composition for improving constipation and stool which comprises natural ingredients extracts effective in improving constipation and stool, and its preparation It is about a method.
- constipation When a person consumes food, the nutrients are absorbed by the body's organs, and foods without nutrients are usually excreted in the form of feces after 12 to 72 hours. However, the above feces can not be excreted for some reason, staying in the intestines for a long time is called constipation.
- Constipation can be caused by a variety of mechanisms, it can be divided into functional constipation is secondary to other diseases caused by the disease is not obvious.
- functional constipation is a delay in the time passed through the bowel, or the bowel pass time is difficult when normal or rectal stool discharge is difficult.
- Secondary constipation is caused by diseases such as diabetes, systemic diseases such as hypothyroidism, organic lesions, taking medications that cause constipation, and mental illnesses such as depression or eating disorders. It is important to treat constipation in accordance with the pathogenesis. If there is an organic or mental illness such as colorectal cancer, the treatment of the underlying disease is the first priority.In the case of functional constipation, it is normal bowel movement improvement and diet. Inducing is preferred.
- the body has an average of 5 to 10 kg of stool, which rots in the wrinkles or diverticulum of the colon, weakens the function of the large intestine, and generates toxic gases.
- Toxic gas filled the intestine enters the brain, disturbs the brain function, causing headaches, and also affects the blood circulation by pressing organs such as the uterus, bladder, and prostate, causing congestion and inflammation.
- toxic gas weakens the absorption of oxygen and nutrients in the body, resulting in skin rashes, and intestinal swelling with toxic gas, causing symptoms such as discomfort, shoulder stiffness, low back pain and weight loss due to stool. May turn black, irregular menstrual cycles, or cold symptoms. For this reason, research is being conducted to develop functional foods that can improve constipation.
- the present invention relates to a health food composition for improving constipation, wherein the composition of raw soybeans and soybeans is a combination of raw soybeans and soybeans, and the soybeans and soybeans show their efficacy and constipation improvement.
- the prior art has the effect of improving constipation, but due to the peculiar smell occurring in Cheonggukjang there is a problem that is not easy to ingest.
- Korean Patent Publication No. 10-1584632 has been made to improve such a problem
- the prior art relates to a coffee composition that can improve bowel movements and alleviate constipation, more specifically, with lactic acid bacteria and coffee It contains a lactitol to smooth the bowel movements, and can provide a constipation prevention and relieve effect, and relates to a coffee composition that helps to promote health while enjoying a favorite food coffee.
- the prior art has the effect of improving constipation by lactic acid bacteria, sleep disorders may occur due to the intake of caffeine contained in coffee.
- the present invention is effective to extract the natural material extracted from the natural material blend consisting of cha-epi, innerwear, seaweed, packing, baekbokyeong, presbytery, jisil, crust, baekchul, linseed and mine It is an object to provide a composition comprising the component.
- the present invention is a constipation and stool improvement composition for improving constipation and stool with natural material extract extracted from the natural material blend consisting of cha jeonpi, nagyeokja, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mine. It is an object to provide a manufacturing method.
- the present invention provides a composition for improving constipation and stool with natural material extract extracted from natural material blends consisting of cha-e-p, endodontic, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed, and mein. .
- the present invention provides the effect of improving the constipation and stool is a natural material extract extracted from the natural material combination consisting of cha bark, nagakja, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mine.
- the present invention is a step (A1) and the step (A1) of extracting the natural material extract from the natural material blend consisting of cha-epi, innerwear, seaweed, packing, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mine
- the present invention also provides granules, powders, pills prepared by the above production method.
- the present invention is a composition for improving constipation and stool, using natural material extract extracted from natural material blends consisting of cha-e-p, naebok, seaweed, bale, baekbokyeong, presbytery, jisil, crust, baekchul, linseed and maine. Has the effect of providing.
- the present invention has the effect of improving the constipation and stool is a natural material extract extracted from the natural material blend consisting of cha bark, nagakja, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mine.
- the present invention is to prepare a composition for improving constipation and stool with natural material extract from the natural material blend consisting of cha-epi, nagyeokja, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mein. Has the effect of providing a method.
- FIG. 1 is a flow chart showing a method for preparing constipation and stool improvement composition using the natural material extract according to the present invention as an active ingredient.
- composition of this invention is demonstrated.
- the composition of the present invention is a composition for improving constipation and stool, which is a natural ingredient extract extracted from natural material blends consisting of cha jeonpi, nagakja, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mine. It is characterized by.
- composition for improving constipation and stool with natural ingredients extract according to an embodiment of the present invention as an active ingredient, 15 to 45% by weight, total weight 1 to 10% by weight, seaweed 5 to 30% by weight , 5 to 30% by weight, 1 to 7% by weight of Baekbokyeong, 5 to 20% by weight of presbytery, 1 to 7% by weight of crust, 1 to 10% by weight of crust, 1 to 7% by weight of flaxseed, 1 to 7% by weight of flax seed And it is characterized in that it comprises a natural material extract extracted from the natural material blend consisting of 1 to 7% by weight of mine.
- the chaff blood is made by crushing the shell of the chajeon made to be suitable for edible, and contains dietary fiber, vitamins A, C, K, in particular, contains a large amount of arobino-xylan-polysaccharide (arobino-xylan-polysaccharide) Excellent moisture retention.
- the dietary fiber of the chapel blood absorbs water to increase the volume of the stool, stimulates the intestines, and helps defecation.If the daily intake of the chapel blood is over 3.9g, the bowel activity becomes smooth, and if it exceeds 5.5g, it lowers the blood cholesterol level. It is reported to help.
- the chaff of the present invention is preferably 15 to 45% by weight relative to the total weight of the composition of one embodiment.
- the content of the chajeonpi is less than 15% by weight, the lack of dietary fiber content of the chajeonpi do not help bowel movements, when the content of more than 45% by weight, the intestinal irritation caused by the dietary fiber of chajeonpi is excessive, diarrhea, abdominal pain, headache It is not preferable because it may cause a back.
- the surrender refers to the seeds of Raphanus sativus Linne belonging to the Cruciferaceae, also called the surrender.
- Underwear has the effect of promoting the secretion of stomach acid to help digest food and lower body weight, and is effective in bloating, removal of bile, constipation and diarrhea.
- people with weak stomach or physical strength may cause excessive stomach irritation, so care should be taken.
- the internal medicine contains antibacterial substances, and also shows the inhibitory effect of Staphylococcus aureus, Escherichia coli and skin fungi, lowering blood pressure and anticancer activity.
- sulforaphan of the internal wearer is a mutation that can come from cooked food. It has been reported to have strong antimutagenic activity against heterocyclic amines, which are native substances.
- Internal wearer of the present invention is preferably 1 to 10% by weight relative to the total weight of the composition of one embodiment. If the content of the surrender is less than 1% by weight, the effect of the surrender is insufficient due to lack of content does not help to improve the digestion of food, constipation, if more than 10% by weight, it may cause gastrointestinal disorder by promoting excessive gastric acid secretion Not desirable
- the seaweed is a precursor of Hijikia fusiforme Okamura or Sargassum pallidum C. Agardh belonging to the Seahorse family.
- alginic acid a kind of dietary fiber, has the effect of releasing heavy metals into the body.
- inorganic salts such as potassium, iodine, and calcium contained in seaweed prevent blood vessel degeneration, lower cholesterol, and smooth blood circulation, thereby helping to improve hyperlipidemia.
- Seaweed is rich in iodine, which helps improve thyroid disease.
- the seaweed contains inorganic arsenic, especially in the case of ⁇ contains a large amount of inorganic arsenic than other algae, and when ingested a large amount of inorganic arsenic is known to cause symptoms of poisoning.
- the seaweed of the present invention is not preferably 5 to 30% by weight relative to the total weight of the composition of one embodiment. If the content of the seaweed is less than 5% by weight, the effect of defecation and heavy metal discharge by the seaweed is insignificant, and if it is more than 30% by weight, it is not preferable because a large amount of inorganic arsenic of the seaweed can be ingested.
- the bales are dried fronds of kelp (Laminaria japonica ARESCH.) And Ecklonia kurome OKAM. Packing is tonic action, thyroid function control, anticancer action, blood pressure lowering, arteriosclerosis, weak diarrhea, and diuretic.
- the iodine of bale increases metabolism by increasing the body's energy consumption to help obesity, and is effective in goiter, while excessive intake of iodine can inhibit the production of thyroid hormones.
- Packing alginic acid has the effect of lowering cholesterol levels and blood pressure, stimulating bowel movements to defecate, and releasing heavy metals to the body. Since there is a lot of dietary fiber, people with frequent diarrhea or hyperthyroidism need to be careful when eating.
- the packing of the present invention is preferably 5 to 30% by weight relative to the total weight of the composition of one embodiment.
- the content of the bale is less than 5% by weight, the effect of defecation and heavy metal discharge by bales is insignificant, and when it is more than 30% by weight, it is not preferable because the production of thyroid hormone can be suppressed by ingesting a large amount of iodine of the bale. .
- the Baekbokryeong is a fungi that are parasitic on the roots of pine trees. Among them, pine roots among the fungus are called fuxin, and the skin of the fungus is called Bokryeongpi. According to the color of the inside, red is called Red Bok-Ryeong, and the red section of the Red Bok-Ryeong is only the white part called Baek-Bok-Ryeong.
- Baekbokryeong contains carbohydrate, water, potassium, magnesium, calcium and the like, and beta Pachman, pakimic acid, ergosterol and the like are known as main components. Some components of Baekbokryeong have been reported to have anti-cancer effects.
- triterpene components have been reported to be effective for anti-emetic, anti-inflammatory and anti-skin cancer.
- baekbokyeong diuretic effect diuretic reduction of edema due to diuretic effect, chronic gastritis, abdominal pain, hypoglycemic effect, blood sugar, etc., and helps to insomnia by relieving nerve hypersensitivity.
- Baekbokryeong of the present invention is preferably 1 to 7% by weight relative to the total weight of the composition of one embodiment.
- the content of the Baekbokryeong is less than 1% by weight, the effects of diuretic action and abdominal pain relief of Baekbokryeong are insufficient, and when it is more than 7% by weight, the diuretic action may be severe and dehydration may occur.
- the presbytery is a perennial herb of the genus Liaceae, whose taste is bitter and cold and acts on the liver and large intestine. Presbytery helps reduce the fever of the liver and helps to relieve headaches, dizziness, and stuffy chest. In addition, the presbytery is effective in constipation and habitual constipation that is agglomerated by heat, and has the effect of eliminating parasites. However, people with weak digestive organs, cold or diarrhea should be careful to use, especially for pregnant women. Other pharmacological actions of presbyopia have been reported, such as hypoglycemia, anti-inflammatory action, antibacterial action, antiviral action, anti-type action, protection against liver damage, wound fusion.
- Presbytery of the present invention is preferably 5 to 20% by weight relative to the total weight of the composition of one embodiment. If the content of the presbytery is less than 5% by weight, the lowering and insecticidal action by the presbytery is inadequate, and if the content of the presbytery is more than 20% by weight, the bitter taste of the presbytery may become strong or the stomach may be burdened by a weak digestive organ. .
- the fruit is an unripe fruit of a tanza, with a characteristic smell, bitter taste, and cold nature.
- the basement contains hesperidin, naringin, cinephrine, ponsyrin, etc., and is effective in strengthening capillaries, improving cholesterol levels, improving blood flow, anti-allergy, carcinogenesis, and suppressing appetite.
- it is also effective in treating diarrhea due to the heat of the stomach and intestine, strengthening the contraction of the uterus, diuresis, promoting digestive tract movement, and abdominal pain due to constipation, while excessive ingestion can cause vomiting, swelling or increased blood pressure. May appear.
- the fruit of the present invention is preferably 1 to 7% by weight relative to the total weight of the composition of one embodiment.
- the content of the fat is less than 1% by weight, diuresis and digestive tract movement promoting action due to the insufficiency is inadequate, and when it is more than 7% by weight, sour taste is strong, it is not preferable because it may cause vomiting, edema, blood pressure increase.
- the crust is the fruit of the tangerine or its cultivar, and in Korea, it refers to the mature fruit of the tangerine. Perception is the same effect as loss and contains neohesperidin, naringin, and vitamin C. The crust is slower than the crust, and it does not spread and is gathered in one place. When the chest and stomach are stuffy, the food is stagnant, or used for abdominal pain caused by constipation. In addition, perception promotes bowel movements, and is also effective in digestive disorders by peptic digestion, but because of the effect of promoting blood pressure rise and peristalsis in the stomach, it is recommended that people with weak stomach intake.
- Perception of the present invention is preferably 1 to 10% by weight relative to the total weight of the composition of one embodiment. If the content of the crust is less than 1% by weight, the effect of promoting bowel movements is insignificant, and if it is more than 10% by weight, it is not preferable because excessive stomach peristalsis can cause upset stomach.
- the baekchul is the root stem of an insert or baekchul belonging to the chrysanthemum, as it is or removed the bark, also called an insert.
- Baekchul contains atlactilol, atlactilone and vitamin A. The taste is sweet, spicy, bitter, and warm. It is effective in strengthening the spleen and stomach, stabilizing the spleen and fighting the body. It is also effective in renal dysfunction and dizziness due to renal dysfunction. It is also effective in diarrhea, jaundice, edema, headache and overeating. . However, if you take long-term baekchul because of the lack of fluid in the body, the lack of water in the body has a fever or thirst due to lack of fluid should be careful when taking.
- Whitening of the present invention is preferably 1 to 7% by weight relative to the total weight of the composition of one embodiment.
- the content of the leachate is less than 1% by weight, the effect of strengthening the spleen and stomach due to the lack of the content of baekchul is insufficient, and when it is more than 7% by weight, it is not preferable because diuretic action by baekchul may be severe.
- the mine refers to the seeds of hemp belonging to the mulberry family, it is also called the lower room, mazarine, flower.
- Mine has an unusual smell, tastes sweet, and works on the spleen, stomach, and large intestine. Maine contains oleic acid, linolenic acid, lecithin, choline, etc., and it has the effect of strengthening the stomach.
- the stimulation of the mucous membrane of the mucous membranes to promote the secretion of mucus and promote peristalsis movement to smooth bowel movements, stop thirst, and active blood circulation has the effect of releasing the blood.
- Mine causes vomiting and diarrhea when used excessively, and when it passes, it becomes paralyzed and should be used with caution.
- the mine of the present invention is preferably 1 to 7% by weight relative to the total weight of the composition of one embodiment. If the content of the mine is less than 1% by weight, the effect of strengthening the spleen and stomach due to lack of the content of the main body is insufficient, and lower than the lowering effect, if it is more than 7% by weight, vomiting, diarrhea, etc. may not be preferable. .
- the flax seeds are ripe seeds of flax belonging to the flax family, contain essential unsaturated fatty acids, lignans, etc., and are also referred to as yam and homaine.
- Unsaturated fatty acids in linseed reduce cholesterol to facilitate blood circulation and regulate blood sugar.
- Lignan of linseed has an antioxidant effect that inhibits the aging of cells in the body by free radicals, protects the barrier and releases heavy metals in vitro.
- flaxseed is rich in dietary fiber has the effect of excretion of stool in the large intestine and prevent constipation.
- flaxseed has a toxic substance, and when ingested, side effects such as headache, vomiting, diarrhea and abdominal pain occur.
- Flax seed of the present invention is preferably 1 to 7% by weight relative to the total weight of the composition of one embodiment.
- the amount of flaxseed is less than 1% by weight, the content of flaxseed is insufficient, so that the effect of stool and heavy metals are insufficient, and when it is more than 7% by weight, side effects of headache, diarrhea and vomiting may appear.
- constipation and stool improvement composition according to the present invention improves constipation, exhibits the effect of removing stool, due to improved constipation can be easily discharged waste and toxins in the body to see the detoxification effect, stool removal You can see the effects of weight loss.
- the manufacturing method of the present invention preferably includes the following steps, but is not limited thereto.
- the present invention is to extract the natural material extract from the natural material blend consisting of chajapi, innerwear, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mein (A1) and the natural of the step (A1) Concentrating the material extract to prepare a natural material concentrate (A2) and drying and powdering the natural material blend to produce a natural material powder (B1) and the natural material concentrate and the step (A2) ( Step (C1) of preparing a granule, powder, pills by mixing the natural material powder of B1).
- an extraction solvent is prepared by mixing purified water and food alcohol in a weight ratio of 8: 2 to 5: 5.
- the food alcohol is preferably ethanol.
- the extraction solvent is relatively increased alcohol component, the process for removing the remaining alcohol after extraction is added, and if the weight ratio of alcohol to purified water is more than 8 weight ratio alcohol component is relatively reduced There is a problem that the extracts are not evenly extracted from each natural material.
- the natural material is washed and blended, and then, 1,000 to 5,000 mL of the extraction solvent is put therein, followed by extracting the natural material extract under vacuum at a temperature of 75 to 95 ° C. for 8 to 10 hours (A1). .
- the natural materials When the natural materials are blended, it includes cha-chae blood, oral gland, seaweed, bale, baekbokyeong, presbytery, jisil, crust, baekchul, mein and linseed.
- step (A2) After obtaining the natural material extract in the step (A1), performing a step (A2) to concentrate the natural material extract of the step (A1).
- 500 to 1,000 mL of mixed natural material concentrate is prepared by vacuum low temperature concentration of 1,000 to 5,000 mL of natural material extract.
- the vacuum low temperature concentration method is a low temperature (40 to 90 °C) in a vacuum state in order to concentrate the heat-affected material or the material oxidized by air, which is concentrated without damaging the natural drug effect.
- the step (B1) of drying and powdering the natural material is performed.
- the step (B1) after washing and blending the natural material clean, and dried in a dryer for 8 to 10 hours at a temperature of 65 to 75 °C, to prepare a natural material powder of 100 to 300 mesh.
- the natural materials When the natural materials are blended, it includes cha-chae blood, oral gland, seaweed, bale, baekbokyeong, presbytery, jisil, crust, baekchul, mein and linseed.
- the natural material concentrate is prepared by the step (A2)
- the natural material powder is prepared by the step (B1)
- the granules, powders and pills are prepared as follows (C1).
- the natural material concentrate and the excipient are combined in a weight ratio of 1: 1 to 4: 1, and then granules are prepared by lyophilization.
- the said excipient is added in order to give a suitable firmness or shape to a chemical
- the concentration of the natural material is less than 1 weight ratio of the excipients, there is no effect of preventing and improving constipation. If the concentration exceeds 4 weight ratios of the excipients, it is difficult for the natural material concentrate and the excipient to aggregate with each other.
- the natural material concentrate and the natural material powder is mixed at a weight ratio of 1: 1 to 4: 1, and dried at a temperature of 65 to 75 ° C. for 8 to 10 hours to prepare a powder of 100 to 300 mesh.
- the extraction solvent was prepared by mixing purified water and food alcohol (ethanol) in a 7: 3 weight ratio.
- composition of the present invention was prepared by mixing in the content of the composition as follows.
- step (A2) After obtaining the natural material extract, 3,000 mL of the natural material extract of step (A1) was concentrated to 1,000 mL by vacuum low temperature concentration to prepare a natural material concentrate.
- step (C1) blending the natural material concentrate and corn powder (excipient) of the step (A2) in a 2: 1 weight ratio to prepare a granule by lyophilization, and the natural material concentrate of step (A2) and the step (B1)
- the experimental group was ingested 4-5 g of the composition of the Example twice daily with 100 mL of water 30 minutes before breakfast and dinner, for a total of 14 days, and no other constipation-enhancing dietary supplements or drugs during this period. .
- the control group was ingested 100 mL of water twice daily for 14 minutes before breakfast and dinner, and no other dietary supplements or drugs for improving constipation during this period.
- the experimental group ingested the composition for improving constipation and stool improvement according to the present invention showed an improvement in irregular bowel activity, lower abdominal pain and discomfort, weight loss, the control group with irregular bowel activity It was generally ineffective in belly abdominal pain, discomfort and weight loss. This was confirmed that the composition for improving constipation and stool improvement according to the present invention has the effect of improving bowel movements and constipation, stool is removed to show the effect of weight loss.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a composition containing a natural material extract as an active ingredient for alleviating constipation and coprostasis and a preparation method therefor. The present invention provides a composition for alleviating constipation and coprostasis and a preparation method therefor, the composition containing, as an active ingredient, a natural material extract extracted from a natural material mixture composed of Plantaginis Semen Testa, Raphani Semen, Eucheumae Thallus, Laminariae Thallus, Poria(Hoelen), Aloe, Aaurantii Immaturus Fructus, Aurantii Fructus Pericarpium, Atractylodis Rhizoma Alba, linseed, and Cannabis Fructus. The composition for alleviating constipation and coprostasis according to the present invention can assist constipation alleviation and coprostasis removal, and the preparation method for the composition for alleviating constipation and coprostasis according to the present invention provides the convenience of allowing a user to easily take the natural material extract by preparing the natural material extract into granules, a powder, or pills.
Description
본 발명은 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물 및 그의 제조방법에 관한 것으로, 상세하게는 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물을 추출, 농축, 분말 단계를 거쳐, 과립제, 산제, 환제로 제조함으로써, 변비 및 숙변 개선에 효과가 있는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물 및 그의 제조방법에 관한 것이다.The present invention relates to a composition for improving constipation and stool with natural ingredients as an active ingredient, and a method for producing the same, and in detail, cha jeonpi, innerwear, seaweed, packing, baekbokyeong, presbytery, jisil, crust, baekchul, linseed and By extracting, concentrating, and powdering a natural ingredient blend consisting of mines, and preparing granules, powders, and pills, the composition for improving constipation and stool, which comprises natural ingredients extracts effective in improving constipation and stool, and its preparation It is about a method.
현대 사회는 생활수준이 향상되고 사회생활이 다양해지면서, 식생활의 서구화 및 인스턴트의 섭취로 열량의 섭취는 늘어난 반면, 섬유소 섭취의 감소와 스트레스의 증가, 운동량의 저하로 인해 변비가 있거나, 비만해지는 인구가 늘어나고 있다. 더욱이, 불규칙한 식사, 대기오염, 식품에 함유된 농약이나 중금속의 섭취, 항생제의 과다복용, 지나친 음주 등으로 인하여 독성이 인체에 축적되는 것을 피할 수 없게 되었다.In modern society, as the standard of living is improved and social life is diversified, calorie intake is increased due to westernization of diet and instant intake, while constipated or obese population is reduced due to decreased fiber intake, increased stress, and decreased exercise. Is growing. Moreover, irregular diet, air pollution, ingestion of pesticides or heavy metals in foods, overdose of antibiotics, and excessive drinking have led to the inevitable accumulation of toxicity in the human body.
사람이 음식을 섭취하게 되면, 영양성분은 인체의 기관에 의해 흡수되고 영양성분이 빠진 음식물은 보통 12~72시간 후에 대변의 형태로 배설되는 것이 일반적이다. 그러나 상기의 대변이 어떠한 이유로 배설되지 못하고, 장안에 오랜시간 머물게 되는 것을 변비라고 한다. When a person consumes food, the nutrients are absorbed by the body's organs, and foods without nutrients are usually excreted in the form of feces after 12 to 72 hours. However, the above feces can not be excreted for some reason, staying in the intestines for a long time is called constipation.
변비는 다양한 기전에 의해 발생할 수 있는데, 다른 질환에 의한 이차성 변비와 원인 질환이 뚜렷하지 않은 기능성 변비로 구분할 수 있다. 이 중 기능성 변비는 대변의 대장 통과 시간이 지연되거나, 대변의 대장 통과 시간은 정상이나 직장으로부터 대변 배출이 어려운 경우이다. 이차성 변비는 당뇨병, 갑상선 기능 저하증 등의 전신질환, 기질적인 병변, 변비를 유발하는 약제의 복용, 우울증 또는 식이장애 등의 정신적인 질환 등의 질환에 의해 발생된다. 변비의 치료는 발병기전에 맞게 치료하는 것이 중요한데, 대장암과 같은 기질적인 질환이나 정신적인 질환이 있을 경우에는 원인 질환의 치료가 우선이며, 기능성 변비의 경우, 생활습관 개선과 식이요법으로 정상적인 배변을 유도하는 것이 우선된다.Constipation can be caused by a variety of mechanisms, it can be divided into functional constipation is secondary to other diseases caused by the disease is not obvious. Among these, functional constipation is a delay in the time passed through the bowel, or the bowel pass time is difficult when normal or rectal stool discharge is difficult. Secondary constipation is caused by diseases such as diabetes, systemic diseases such as hypothyroidism, organic lesions, taking medications that cause constipation, and mental illnesses such as depression or eating disorders. It is important to treat constipation in accordance with the pathogenesis. If there is an organic or mental illness such as colorectal cancer, the treatment of the underlying disease is the first priority.In the case of functional constipation, it is normal bowel movement improvement and diet. Inducing is preferred.
변비가 생기면 대장의 기능이 떨어지면서 수분이 과다하게 제거되어 음식 찌거기 등의 노폐물과 대변의 독성 물질이 배출되지 못하고, 신진대사가 제대로 이루어지지 않아 장에 대변이 오래 머물게 되어 숙변이 나타난다.When constipation occurs, the function of the colon is reduced, excess water is removed, wastes such as food residues and toxic substances of feces are not discharged, and metabolism is not properly performed, so the bowel remains for a long time in the intestines.
체내에는 평균 5 내지 10 kg의 숙변이 있는데, 숙변은 대장의 주름이나 게실에 담겨 썩으면서 대장의 기능을 약화시키고, 유독가스를 발생한다. 장에 가득찬 유독가스는 혈액을 타고 뇌로 들어가 뇌 기능을 어지럽혀 두통이 일으킬 뿐 아니라, 자궁, 방광, 전립선 등의 장기를 압박하여 혈액순환에 영향을 주어 충혈과 염증을 일으킨다. 또한, 유독가스로 인해 체내 산소와 영양소 흡수가 약화되어 피부 발진이 나타나며, 유독가스로 장이 팽창하여 불쾌감, 어깨결림, 요통 및 숙변에 의한 체중 증가 등의 증상이 나타나고, 여성은 생리통이 심해지면서 생리혈의 색깔이 검게 변하거나, 불규칙한 생리주기, 냉증이 나타나기도 한다. 이러한 이유로 변비를 개선할 수 있는 기능성 식품 개발하는 연구가 이루어지고 있다.The body has an average of 5 to 10 kg of stool, which rots in the wrinkles or diverticulum of the colon, weakens the function of the large intestine, and generates toxic gases. Toxic gas filled the intestine enters the brain, disturbs the brain function, causing headaches, and also affects the blood circulation by pressing organs such as the uterus, bladder, and prostate, causing congestion and inflammation. In addition, toxic gas weakens the absorption of oxygen and nutrients in the body, resulting in skin rashes, and intestinal swelling with toxic gas, causing symptoms such as discomfort, shoulder stiffness, low back pain and weight loss due to stool. May turn black, irregular menstrual cycles, or cold symptoms. For this reason, research is being conducted to develop functional foods that can improve constipation.
변비를 개선할 수 있는 식품과 관련된 종래기술로는 대한민국 등록특허공보 제10-1174723호가 있는데, 상기 종래기술은 청국장 30 내지 70중량%와 생콩 30 내지 70중량%와 이루어진 생콩 청국장 조성물 및 이를 유효성분으로 함유하는 변비 개선용 건강식품 조성물에 관한 것으로, 생콩 청국장 조성물은 생콩과 청국장을 결합시킴으로써, 생콩과 청국장이 각각의 효능 및 변비 개선의 효과를 나타내는 것이다. 상기 종래기술은 변비 개선의 효과가 있지만, 청국장에 발생하는 특유의 냄새로 인해 섭취가 용이하지 않은 문제점이 있다.Conventional technology related to foods that can improve constipation is Republic of Korea Patent Publication No. 10-1174723, the prior art is composed of 30 to 70% by weight of Cheonggukjang and 30 to 70% by weight of raw beans and soybean paste composition The present invention relates to a health food composition for improving constipation, wherein the composition of raw soybeans and soybeans is a combination of raw soybeans and soybeans, and the soybeans and soybeans show their efficacy and constipation improvement. The prior art has the effect of improving constipation, but due to the peculiar smell occurring in Cheonggukjang there is a problem that is not easy to ingest.
이러한 문제점을 개선한 종래기술로는 대한민국 등록특허공보 제10-1584632호가 있는데, 상기 종래기술은 배변 활동을 향상시키고 변비를 완화시킬 수 있는 커피 조성물에 관한 것으로서, 보다 상세하게는 커피와 함께 유산균 및 락티톨을 함께 포함하여 배변이 원활하게 이루어지게 하며, 변비 예방 및 완화 효과를 제공할 수 있어 기호식품인 커피를 즐기면서 건강 증진에도 도움이 되는 커피 조성물에 관한 것이다. 상기 종래기술은 유산균에 의해 변비가 개선되는 효과가 있지만, 커피에 함유된 카페인의 섭취로 수면장애가 발생할 수 있다.Korean Patent Publication No. 10-1584632 has been made to improve such a problem, the prior art relates to a coffee composition that can improve bowel movements and alleviate constipation, more specifically, with lactic acid bacteria and coffee It contains a lactitol to smooth the bowel movements, and can provide a constipation prevention and relieve effect, and relates to a coffee composition that helps to promote health while enjoying a favorite food coffee. The prior art has the effect of improving constipation by lactic acid bacteria, sleep disorders may occur due to the intake of caffeine contained in coffee.
상기와 같은 종래 기술의 문제점을 해결하기 위하여, 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물을 유효성분으로 하는 조성물을 제공하는 목적이 있다.In order to solve the problems of the prior art as described above, the present invention is effective to extract the natural material extracted from the natural material blend consisting of cha-epi, innerwear, seaweed, packing, baekbokyeong, presbytery, jisil, crust, baekchul, linseed and mine It is an object to provide a composition comprising the component.
또한, 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법을 제공하는 목적이 있다. In addition, the present invention is a constipation and stool improvement composition for improving constipation and stool with natural material extract extracted from the natural material blend consisting of cha jeonpi, nagyeokja, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mine. It is an object to provide a manufacturing method.
아울러, 상기 제조방법으로 과립제, 산제, 환제를 제조하여 사용자가 손쉽게 복용하도록 편의성을 제공하는 목적이 있다.In addition, there is an object of providing a convenience for the user to easily take the preparation of granules, powders, pills by the manufacturing method.
본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물을 제공한다. The present invention provides a composition for improving constipation and stool with natural material extract extracted from natural material blends consisting of cha-e-p, endodontic, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed, and mein. .
또한, 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물이 변비 및 숙변을 개선하는 효과를 제공한다.In addition, the present invention provides the effect of improving the constipation and stool is a natural material extract extracted from the natural material combination consisting of cha bark, nagakja, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mine.
또한, 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 천연재료 추출물을 추출하는 단계(A1)와 상기 단계(A1)의 천연재료 추출물을 농축하여 천연재료 농축액을 제조하는 단계(A2)와 상기 천연재료 배합물을 건조하고 분말화하여 천연재료 분말을 제조하는 단계(B1)와 상기 단계(A2)의 천연재료 농축액과 상기 단계(B1)의 천연재료 분말을 혼합하여 과립제, 산제, 환제를 제조하는 단계(C1);로 이루어진 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법을 제공한다. In addition, the present invention is a step (A1) and the step (A1) of extracting the natural material extract from the natural material blend consisting of cha-epi, innerwear, seaweed, packing, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mine Step (A2) of preparing a natural material concentrate by concentrating the natural material extract of the (D2) and drying and powdering the natural material blend to produce a natural material powder (B1) and the natural material concentrate of the step (A2) and the It provides a method for producing a composition for improving constipation and stool by using the natural material extract consisting of the step (C1) to prepare a granule, powder, pills by mixing the natural material powder of step (B1).
또한, 본 발명은 상기 제조방법으로 제조된 과립제, 산제, 환제를 제공한다.The present invention also provides granules, powders, pills prepared by the above production method.
상기와 같이 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물을 제공하는 효과를 있다. As described above, the present invention is a composition for improving constipation and stool, using natural material extract extracted from natural material blends consisting of cha-e-p, naebok, seaweed, bale, baekbokyeong, presbytery, jisil, crust, baekchul, linseed and maine. Has the effect of providing.
또한, 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물이 변비 및 숙변을 개선하는 효과를 가진다.In addition, the present invention has the effect of improving the constipation and stool is a natural material extract extracted from the natural material blend consisting of cha bark, nagakja, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mine.
또한, 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법을 제공하는 효과를 가진다.In addition, the present invention is to prepare a composition for improving constipation and stool with natural material extract from the natural material blend consisting of cha-epi, nagyeokja, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mein. Has the effect of providing a method.
아울러, 상기 제조방법으로 과립제, 산제, 환제를 제조하여 사용자가 손쉽게 복용하도록 하는 편의성을 가진다.In addition, it has a convenience for the user to easily take the preparation of granules, powders, pills by the manufacturing method.
도 1은 본 발명에 따른 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법을 보여주는 순서도이다.1 is a flow chart showing a method for preparing constipation and stool improvement composition using the natural material extract according to the present invention as an active ingredient.
이하, 본 발명의 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물 및 그의 제조방법을 상세하게 설명한다.Hereinafter, the composition for improving constipation and stool using the natural material extract of the present invention as an active ingredient and a method for producing the same will be described in detail.
우선 본 발명의 조성물에 대해 설명한다.First, the composition of this invention is demonstrated.
본 발명의 조성물은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물인 것을 특징으로 한다.The composition of the present invention is a composition for improving constipation and stool, which is a natural ingredient extract extracted from natural material blends consisting of cha jeonpi, nagakja, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mine. It is characterized by.
또한, 본 발명의 일 실시예에 따른 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물은, 총 중량대비 차전자피 15 내지 45 중량%, 내복자 1 내지 10 중량%, 해조 5 내지 30 중량%, 곤포 5 내지 30 중량%, 백복령 1 내지 7 중량%, 노회 5 내지 20 중량%, 지실 1 내지 7 중량%, 지각 1 내지 10 중량%, 백출 1 내지 7 중량%, 아마인 1 내지 7 중량% 및 마인 1 내지 7중량%으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물을 함유하는 것을 특징으로 한다.In addition, the composition for improving constipation and stool with natural ingredients extract according to an embodiment of the present invention as an active ingredient, 15 to 45% by weight, total weight 1 to 10% by weight, seaweed 5 to 30% by weight , 5 to 30% by weight, 1 to 7% by weight of Baekbokyeong, 5 to 20% by weight of presbytery, 1 to 7% by weight of crust, 1 to 10% by weight of crust, 1 to 7% by weight of flaxseed, 1 to 7% by weight of flax seed And it is characterized in that it comprises a natural material extract extracted from the natural material blend consisting of 1 to 7% by weight of mine.
상기 차전자피는 차전자의 껍질을 분쇄하여 식용에 적합하도록 만든 것을 말하며, 식이섬유, 비타민 A, C, K를 함유하고 있고, 특히, 아로비노-자일란-다당류(arobino-xylan-polysaccharide)를 다량 함유하여 수분 보유량이 뛰어나다. 차전자피의 식이섬유는 수분을 흡수하여 변의 부피를 늘리고, 장을 자극하여 배변에 도움을 주며, 차전자피의 식이섬유 일일 섭취량이 3.9g 이상이면 배변활동이 원활해지고, 5.5g 이상이면 혈중 콜레스테롤 농도를 낮추는데 도움을 주는 것으로 보고되고 있다. The chaff blood is made by crushing the shell of the chajeon made to be suitable for edible, and contains dietary fiber, vitamins A, C, K, in particular, contains a large amount of arobino-xylan-polysaccharide (arobino-xylan-polysaccharide) Excellent moisture retention. The dietary fiber of the chapel blood absorbs water to increase the volume of the stool, stimulates the intestines, and helps defecation.If the daily intake of the chapel blood is over 3.9g, the bowel activity becomes smooth, and if it exceeds 5.5g, it lowers the blood cholesterol level. It is reported to help.
본 발명의 차전자피는 일 실시예의 조성물 중 총 중량대비 15 내지 45 중량%인 것이 바람직하다. 상기 차전피의 함량이 15 중량% 미만인 경우, 차전자피의 식이섬유 함량이 부족하여 배변활동을 도움을 주지 못하며, 45 중량% 초과인 경우, 차전자피의 식이섬유에 의한 장의 자극이 과하여, 설사, 복통, 두통 등을 일으킬 수 있으므로 바람직하지 않다.The chaff of the present invention is preferably 15 to 45% by weight relative to the total weight of the composition of one embodiment. When the content of the chajeonpi is less than 15% by weight, the lack of dietary fiber content of the chajeonpi do not help bowel movements, when the content of more than 45% by weight, the intestinal irritation caused by the dietary fiber of chajeonpi is excessive, diarrhea, abdominal pain, headache It is not preferable because it may cause a back.
상기 내복자는 십자화과에 속하는 무(Raphanus sativus Linne)의 씨를 말하며, 나복자라고도 한다. 내복자는 위산의 분비를 촉진시켜 음식물 소화를 돕고 체한 것을 내려가게 하는 효능이 있어, 복부팽만, 담의 제거, 변비 및 설사에 효과가 있다. 내복자의 섭취시, 비위가 약하거나 체력이 저하된 사람에게는 위에 과한 자극을 줄 수 있어 주의가 필요하다. 근래에는 내복자에 항균물질이 들어 있어 포도상구균, 대장균 및 피부진균의 억제작용, 혈압저하 작용 및 항암작용도 나타내는 것으로 보고되고 있으며, 특히, 내복자의 설포라판(sulforaphan)은 조리한 음식물에서 나올 수 있는 돌연변이원성 물질인 헤테로사이클릭아민(heterocyclic amine)에 대해서 강력한 항돌연변이 활성을 가진다고 보고되고 있다. The surrender refers to the seeds of Raphanus sativus Linne belonging to the Cruciferaceae, also called the surrender. Underwear has the effect of promoting the secretion of stomach acid to help digest food and lower body weight, and is effective in bloating, removal of bile, constipation and diarrhea. When ingested by the patient, people with weak stomach or physical strength may cause excessive stomach irritation, so care should be taken. Recently, it has been reported that the internal medicine contains antibacterial substances, and also shows the inhibitory effect of Staphylococcus aureus, Escherichia coli and skin fungi, lowering blood pressure and anticancer activity. In particular, sulforaphan of the internal wearer is a mutation that can come from cooked food. It has been reported to have strong antimutagenic activity against heterocyclic amines, which are native substances.
본 발명의 내복자는 일실시예의 조성물 중 총 중량대비 1 내지 10 중량%인 것이 바람직하다. 상기 내복자의 함량이 1 중량% 미만인 경우, 함량 부족으로 내복자의 효과가 미비하여 음식물의 소화, 변비 개선에 도움이 되지 않고, 10 중량% 초과인 경우, 과도한 위산 분비 촉진으로 위장장애를 유발할 수 있으므로 바람직하지 않다.Internal wearer of the present invention is preferably 1 to 10% by weight relative to the total weight of the composition of one embodiment. If the content of the surrender is less than 1% by weight, the effect of the surrender is insufficient due to lack of content does not help to improve the digestion of food, constipation, if more than 10% by weight, it may cause gastrointestinal disorder by promoting excessive gastric acid secretion Not desirable
상기 해조는 해마조과에 속하는 톳(Hijikia fusiforme Okamura) 또는 알쏭이모자반(Sargassum pallidum C. Agardh)의 전조이다. 해조에는 식이섬유가 많아 장운동을 자극하여 배변효과가 있고, 특히, 식이섬유의 일종인 알긴산은 중금속을 체외로 배출시키는 효과가 있다. 또한, 해조에 함유된 칼륨, 요오드, 칼슘 등 무기염류는 혈관의 변성을 막으며, 콜레스테롤을 낮추고, 혈액순환을 원활하게 하여 고지혈증 개선에 도움이 된다. 해조에는 요오드 성분이 풍부해 갑상선 질환을 개선하는데 도움이 된다. 해조에는 무기비소가 포함되어 있고, 특히 톳에는 다른 해조류보다 무기비소가 다량 함유되어 있으며, 무기비소를 다량 섭취시에는 체내에 축적되어 중독증상이 나타날 수 있다고 알려져있다.The seaweed is a precursor of Hijikia fusiforme Okamura or Sargassum pallidum C. Agardh belonging to the Seahorse family. There are many dietary fibers in the seaweed to stimulate bowel movements and have a bowel movement effect. In particular, alginic acid, a kind of dietary fiber, has the effect of releasing heavy metals into the body. In addition, inorganic salts such as potassium, iodine, and calcium contained in seaweed prevent blood vessel degeneration, lower cholesterol, and smooth blood circulation, thereby helping to improve hyperlipidemia. Seaweed is rich in iodine, which helps improve thyroid disease. The seaweed contains inorganic arsenic, especially in the case of 톳 contains a large amount of inorganic arsenic than other algae, and when ingested a large amount of inorganic arsenic is known to cause symptoms of poisoning.
본 발명의 해조는 일 실시예의 조성물 중 총 중량대비 5 내지 30 중량%인 것이 바람직하지 않다. 상기 해조의 함량이 5 중량% 미만인 경우, 해조에 의한 배변 및 중금속 배출의 효과가 미비하고, 30 중량% 초과인 경우, 해조의 무기비소를 다량 섭취하게 될 수 있으므로 바람직하지 않다.The seaweed of the present invention is not preferably 5 to 30% by weight relative to the total weight of the composition of one embodiment. If the content of the seaweed is less than 5% by weight, the effect of defecation and heavy metal discharge by the seaweed is insignificant, and if it is more than 30% by weight, it is not preferable because a large amount of inorganic arsenic of the seaweed can be ingested.
상기 곤포는 다시마목에 속한 다시마(Laminaria japonica ARESCH.)와 감태(Ecklonia kurome OKAM.)의 엽상체를 건조한 것으로, 해대라고도 한다. 곤포는 강장작용, 갑상선 기능조절작용, 항암작용, 혈압저하, 동맥경화막이작용, 약한 설사작용, 및 이뇨작용을 한다. 특히, 곤포의 요오드는 신진대사를 활발하게 하여 체내 에너지 소모를 증가시키므로 비만에 도움을 주고, 갑상선종에 효과가 있는 반면, 요오드를 지나치게 섭취하면 갑상샘 호르몬의 생성이 억제될 수 있다. 곤포의 알긴산은 콜레스테롤 수치와 혈압을 낮추는 효과, 장운동을 자극하여 배변하는 효과 및 중금속을 체외로 배출시키는 효과가 있다. 곤포에는 식이섬유가 많으므로, 설사가 잦은 사람이나 갑상선 기능항진증이 있는 사람은 섭취시 주의가 필요하다.The bales are dried fronds of kelp (Laminaria japonica ARESCH.) And Ecklonia kurome OKAM. Packing is tonic action, thyroid function control, anticancer action, blood pressure lowering, arteriosclerosis, weak diarrhea, and diuretic. In particular, the iodine of bale increases metabolism by increasing the body's energy consumption to help obesity, and is effective in goiter, while excessive intake of iodine can inhibit the production of thyroid hormones. Packing alginic acid has the effect of lowering cholesterol levels and blood pressure, stimulating bowel movements to defecate, and releasing heavy metals to the body. Since there is a lot of dietary fiber, people with frequent diarrhea or hyperthyroidism need to be careful when eating.
본 발명의 곤포는 일실시예의 조성물 중 총 중량대비 5 내지 30 중량%인 것이 바람직하다. 상기 곤포의 함량이 5 중량% 미만인 경우, 곤포에 의한 배변 및 중금속 배출의 효과가 미비하고, 30 중량% 초과인 경우, 곤포의 요오드를 다량 섭취로 갑상샘 호르몬의 생성을 억제할 수 있으므로 바람직하지 않다.The packing of the present invention is preferably 5 to 30% by weight relative to the total weight of the composition of one embodiment. When the content of the bale is less than 5% by weight, the effect of defecation and heavy metal discharge by bales is insignificant, and when it is more than 30% by weight, it is not preferable because the production of thyroid hormone can be suppressed by ingesting a large amount of iodine of the bale. .
상기 백복령은 소나무 뿌리에 기생하는 균핵으로, 복령은 소나무 뿌리에 버섯균이 침투하여 혹처럼 크게 자란 것을 말린 것이다. 이 중 균핵 가운데 소나무 뿌리가 있는 것을 복신, 균핵의 피부를 복령피라고 한다. 복령은 내부의 색에 따라 담홍색인 것을 적복령이라 하고, 적복령을 절편한 다음 백색 부분만을 백복령이라고 하는데, 일반적으로 복령이란 백복령을 말한다. 백복령은 탄수화물, 수분, 칼륨, 마그네슘, 칼슘 등을 함유하고 있으며, 주성분으로는 베타 파키만, 파킴산, 에르고스테롤 등이 알려져 있다. 백복령의 일부 성분은 항암효과가 있는 것으로 보고되어 있으며, 특히, 트리테르펜 성분은 항구토, 항염증, 항피부암에 효과가 있다고 보고된 바 있다. 또한, 백복령은 이뇨작용, 이뇨작용에 의한 부종의 감소, 만성위염, 복통, 혈당강하작용, 혈허 등에 효과가 있으며, 신경과민을 해소하여 불면증에 도움을 준다. The Baekbokryeong is a fungi that are parasitic on the roots of pine trees. Among them, pine roots among the fungus are called fuxin, and the skin of the fungus is called Bokryeongpi. According to the color of the inside, red is called Red Bok-Ryeong, and the red section of the Red Bok-Ryeong is only the white part called Baek-Bok-Ryeong. Baekbokryeong contains carbohydrate, water, potassium, magnesium, calcium and the like, and beta Pachman, pakimic acid, ergosterol and the like are known as main components. Some components of Baekbokryeong have been reported to have anti-cancer effects. In particular, triterpene components have been reported to be effective for anti-emetic, anti-inflammatory and anti-skin cancer. In addition, baekbokyeong diuretic effect, diuretic reduction of edema due to diuretic effect, chronic gastritis, abdominal pain, hypoglycemic effect, blood sugar, etc., and helps to insomnia by relieving nerve hypersensitivity.
본 발명의 백복령은 일 실시예의 조성물 중 총 중량대비 1 내지 7 중량%인 것이 바람직하다. 상기 백복령의 함량이 1 중량% 미만인 경우, 백복령의 이뇨작용 및 복통 완화의 효과가 미비하고, 7 중량% 초과인 경우, 이뇨작용이 심해져 탈수증상이 나타날 수 있으므로 바람직하지 않다.Baekbokryeong of the present invention is preferably 1 to 7% by weight relative to the total weight of the composition of one embodiment. When the content of the Baekbokryeong is less than 1% by weight, the effects of diuretic action and abdominal pain relief of Baekbokryeong are insufficient, and when it is more than 7% by weight, the diuretic action may be severe and dehydration may occur.
상기 노회는 백합과의 알로에속 다년생 초본이며, 맛은 쓰고 성질은 차며 간과 대장에 작용한다. 노회는 간의 열을 내려주며, 열에 의한 두통, 어지럼증, 가슴이 답답한 증상을 완화하는 효과가 있다. 또한, 노회는 열로 뭉친 변비나 습관성 변비에 효과가 있으며, 기생충을 없애는 효능이 있다. 단, 소화기가 약하고 몸이 차거나, 설사를 자주하는 사람에게는 사용을 주의해야 하며, 임신부에게는 특히 그러하다. 그외 노회의 약리작용으로는 혈당 강하, 항염작용, 항균작용, 항바이러스작용, 항종류작용, 간손상에 대한 보호작용, 상처 유합작용 등이 보고된 바 있다.The presbytery is a perennial herb of the genus Liaceae, whose taste is bitter and cold and acts on the liver and large intestine. Presbytery helps reduce the fever of the liver and helps to relieve headaches, dizziness, and stuffy chest. In addition, the presbytery is effective in constipation and habitual constipation that is agglomerated by heat, and has the effect of eliminating parasites. However, people with weak digestive organs, cold or diarrhea should be careful to use, especially for pregnant women. Other pharmacological actions of presbyopia have been reported, such as hypoglycemia, anti-inflammatory action, antibacterial action, antiviral action, anti-type action, protection against liver damage, wound fusion.
본 발명의 노회는 일실시예의 조성물 중 총 중량대비 5 내지 20 중량%인 것이 바람직하다. 상기 노회의 함량이 5 중량% 미만인 경우, 노회에 의한 사하작용와 살충작용이 미비하고, 20 중량% 초과인 경우, 노회의 쓴맛이 강해지거나, 소화기 약한 사람에게는 위장에 부담을 줄 수 있으므로 바람직하지 않다.Presbytery of the present invention is preferably 5 to 20% by weight relative to the total weight of the composition of one embodiment. If the content of the presbytery is less than 5% by weight, the lowering and insecticidal action by the presbytery is inadequate, and if the content of the presbytery is more than 20% by weight, the bitter taste of the presbytery may become strong or the stomach may be burdened by a weak digestive organ. .
상기 지실은 탱자나무의 익지 않은 열매로, 특유의 냄새가 있고, 맛은 쓰고 시며, 성질은 차다. 지실에는 헤스페리딘, 나린진, 시네프린, 폰시린 등이 함유되어 있어, 모세혈관 강화, 콜레스테롤 수치 개선, 혈류 개선, 항알레르기, 발암억제, 식욕억제 등에 효과가 있다. 또한, 지실은 위장과 대장의 열기에 의한 설사 치료, 자궁 수축력 강화, 이뇨작용, 소화관 운동 촉진, 변비로 인한 복통에도 효과가 있는 반면, 지실을 과다섭취하면 구토가 발생할 수 있고, 부종이나 혈압상승이 나타날 수 있다.The fruit is an unripe fruit of a tanza, with a characteristic smell, bitter taste, and cold nature. The basement contains hesperidin, naringin, cinephrine, ponsyrin, etc., and is effective in strengthening capillaries, improving cholesterol levels, improving blood flow, anti-allergy, carcinogenesis, and suppressing appetite. In addition, it is also effective in treating diarrhea due to the heat of the stomach and intestine, strengthening the contraction of the uterus, diuresis, promoting digestive tract movement, and abdominal pain due to constipation, while excessive ingestion can cause vomiting, swelling or increased blood pressure. May appear.
본 발명의 지실은 일실시예의 조성물 중 총 중량대비 1 내지 7 중량%인 것이 바람직하다. 상기 지실의 함량이 1 중량% 미만인 경우, 지실에 의한 이뇨작용와 소화관 운동 촉진작용이 미비하고, 7 중량% 초과인 경우, 신맛이 강해지고, 구토나 부종, 혈압상승을 유발할 수 있으므로 바람직하지 않다.The fruit of the present invention is preferably 1 to 7% by weight relative to the total weight of the composition of one embodiment. When the content of the fat is less than 1% by weight, diuresis and digestive tract movement promoting action due to the insufficiency is inadequate, and when it is more than 7% by weight, sour taste is strong, it is not preferable because it may cause vomiting, edema, blood pressure increase.
상기 지각은 광귤나무 또는 그 재배변종의 과실로, 우리나라에서는 탱자나무의 성숙한 열매를 말한다. 지각은 지실과 효능이 같으며, 네오헤스페리딘, 나린진, 비타민 C 등이 함유되어 있다. 지각은 지실보다 작용이 완만하며, 기가 퍼지지 못하고 한곳에 모여있어 가슴과 배가 답답할 때, 음식이 정체되었거나, 변비로 인한 복통 등에 사용된다. 또한, 지각은 장운동을 촉진하며, 건위소화작용으로 소화장애에도 효과가 있으나, 혈압상승 및 위의 연동운동을 촉진하는 효과도 있으므로 위장이 약한 사람은 섭취를 주의하는 것이 좋다.The crust is the fruit of the tangerine or its cultivar, and in Korea, it refers to the mature fruit of the tangerine. Perception is the same effect as loss and contains neohesperidin, naringin, and vitamin C. The crust is slower than the crust, and it does not spread and is gathered in one place. When the chest and stomach are stuffy, the food is stagnant, or used for abdominal pain caused by constipation. In addition, perception promotes bowel movements, and is also effective in digestive disorders by peptic digestion, but because of the effect of promoting blood pressure rise and peristalsis in the stomach, it is recommended that people with weak stomach intake.
본 발명의 지각은 일실시예의 조성물 중 총 중량대비 1 내지 10 중량%인 것이 바람직하다. 상기 지각의 함량이 1 중량% 미만인 경우, 장운동의 촉진하는 효과가 미비하고, 10 중량% 초과인 경우, 과도한 위의 연동운동으로 배탈을 일으킬 수 있으므로 바람직하지 않다.Perception of the present invention is preferably 1 to 10% by weight relative to the total weight of the composition of one embodiment. If the content of the crust is less than 1% by weight, the effect of promoting bowel movements is insignificant, and if it is more than 10% by weight, it is not preferable because excessive stomach peristalsis can cause upset stomach.
상기 백출은 국화과에 속하는 삽주 또는 백출의 뿌리줄기로서 그대로 또는 주피를 제거한 것이며, 삽주라고도 한다. 백출에는 아트락틸롤, 아트락틸론, 비타민 A 등이 함유되어 있고, 맛은 달고 맵고 쓰며, 따뜻한 성질을 가지고 있다. 백출은 비장과 위장을 튼튼하게 하고, 비장을 안정시켜 체기를 물리치는 효능이 있고, 신장의 기능장애로 인한 빈뇨증, 어지럼증에 효과가 있으며, 설사, 황달, 부종, 두통 및 과식 등에도 효과가 있다. 단, 백출을 장기간 복용하면 체내의 진액이 부족하게 되므로, 체내에 수분이 부족하여 열이 있거나, 진액이 부족하여 갈증이 많은 사람은 복용시 주의하여야 한다.The baekchul is the root stem of an insert or baekchul belonging to the chrysanthemum, as it is or removed the bark, also called an insert. Baekchul contains atlactilol, atlactilone and vitamin A. The taste is sweet, spicy, bitter, and warm. It is effective in strengthening the spleen and stomach, stabilizing the spleen and fighting the body. It is also effective in renal dysfunction and dizziness due to renal dysfunction. It is also effective in diarrhea, jaundice, edema, headache and overeating. . However, if you take long-term baekchul because of the lack of fluid in the body, the lack of water in the body has a fever or thirst due to lack of fluid should be careful when taking.
본 발명의 백출은 일실시예의 조성물 중 총 중량대비 1 내지 7 중량%인 것이 바람직하다. 상기 백출의 함량이 1 중량% 미만인 경우, 백출의 함량이 부족하여 비장과 위장을 튼튼하게 하는 효과가 미비하고, 7 중량% 초과인 경우, 백출에 의한 이뇨작용이 심해질 수 있으므로 바람직하지 않다.Whitening of the present invention is preferably 1 to 7% by weight relative to the total weight of the composition of one embodiment. When the content of the leachate is less than 1% by weight, the effect of strengthening the spleen and stomach due to the lack of the content of baekchul is insufficient, and when it is more than 7% by weight, it is not preferable because diuretic action by baekchul may be severe.
상기 마인은 뽕나무과에 속하는 삼의 씨를 말하며, 저실, 마자인, 화마인이라고도 한다. 마인은 특이한 냄새가 나고, 맛은 달며, 비장과 위, 대장에 작용한다. 마인에는 올레인산, 리놀렌산, 레시틴, 콜린 등이 함유되어 있으며, 비위를 튼튼하게 하는 효과가 있다. 또한 마인은 장점막의 자극으로 점액질의 분비를 촉진하고 연동운동을 촉진하여 배변이 원활하도록 하며, 갈증을 그치게 하고, 혈액순환을 활발히 하여 어혈을 풀어주는 효과도 있다. 마인은 과량을 쓰면 구토, 설사 증상이 나타나며, 이것이 경과되면 마비작용으로 이행되므로, 사용시 주의하여야 한다.The mine refers to the seeds of hemp belonging to the mulberry family, it is also called the lower room, mazarine, flower. Mine has an unusual smell, tastes sweet, and works on the spleen, stomach, and large intestine. Maine contains oleic acid, linolenic acid, lecithin, choline, etc., and it has the effect of strengthening the stomach. In addition, the stimulation of the mucous membrane of the mucous membranes to promote the secretion of mucus and promote peristalsis movement to smooth bowel movements, stop thirst, and active blood circulation has the effect of releasing the blood. Mine causes vomiting and diarrhea when used excessively, and when it passes, it becomes paralyzed and should be used with caution.
본 발명의 마인은 일실시예의 조성물 중 총 중량대비 1 내지 7 중량%인 것이 바람직하다. 상기 마인의 함량이 1 중량% 미만인 경우, 마인의 함량이 부족하여 비장과 위장을 튼튼하게 하는 효과 및 사하작용이 미비하고, 7 중량% 초과인 경우, 구토, 설사 등이 나타날 수 있으므로 바람직하지 않다.The mine of the present invention is preferably 1 to 7% by weight relative to the total weight of the composition of one embodiment. If the content of the mine is less than 1% by weight, the effect of strengthening the spleen and stomach due to lack of the content of the main body is insufficient, and lower than the lowering effect, if it is more than 7% by weight, vomiting, diarrhea, etc. may not be preferable. .
상기 아마인은 아마과에 속하는 아마의 잘 익은 씨로, 필수 불포화 지방산, 리그난 등을 함유하고 있으며, 호마자, 호마인이라고도 한다. 아마인의 불포화 지방산은 콜레스테롤을 감소시켜 혈액순환을 원활히 하며 혈당을 조절하는 효과가 있다. 아마인의 리그난은 활성산소에 의한 체내 세포의 노화를 억제하는 항산화 효과가 있으며, 장벽을 보호하고 중금속을 체외로 배출하는 효과가 있다. 또한, 아마인은 식이섬유소가 풍부하여 대장에 있는 숙변을 배출하고 변비를 예방하는 효과가 있다. 단, 아마인에는 독성물질이 있어 과량 섭취시에는 두통, 구토, 설사, 복통 등의 부작용이 나타난다.The flax seeds are ripe seeds of flax belonging to the flax family, contain essential unsaturated fatty acids, lignans, etc., and are also referred to as yam and homaine. Unsaturated fatty acids in linseed reduce cholesterol to facilitate blood circulation and regulate blood sugar. Lignan of linseed has an antioxidant effect that inhibits the aging of cells in the body by free radicals, protects the barrier and releases heavy metals in vitro. In addition, flaxseed is rich in dietary fiber has the effect of excretion of stool in the large intestine and prevent constipation. However, flaxseed has a toxic substance, and when ingested, side effects such as headache, vomiting, diarrhea and abdominal pain occur.
본 발명의 아마인은 일실시예의 조성물 중 총 중량대비 1 내지 7 중량%인 것이 바람직하다. 상기 아마인의 함량이 1 중량% 미만인 경우, 아마인의 함량이 부족하여 숙변 및 중금속의 배출 효과가 미비하고, 7 중량% 초과인 경우, 두통, 설사, 구토의 부작용이 나타날 수 있으므로 바람직하지 않다.Flax seed of the present invention is preferably 1 to 7% by weight relative to the total weight of the composition of one embodiment. When the amount of flaxseed is less than 1% by weight, the content of flaxseed is insufficient, so that the effect of stool and heavy metals are insufficient, and when it is more than 7% by weight, side effects of headache, diarrhea and vomiting may appear.
상기 본 발명에 따른 변비 및 숙변 개선용 조성물은 변비를 개선하고, 숙변을 제거하는 효과를 나타내며, 변비 개선으로 인해 체내의 노폐물과 독소물질의 배출이 원활하여 해독효과를 볼 수 있으며, 숙변제거로 인한 체중감량의 효과를 볼 수 있다.The constipation and stool improvement composition according to the present invention improves constipation, exhibits the effect of removing stool, due to improved constipation can be easily discharged waste and toxins in the body to see the detoxification effect, stool removal You can see the effects of weight loss.
이하, 본 발명의 제조방법에 대한 바람직한 실시 내용은 첨부한 도면을 참조하여 설명하며, 본 발명의 제조방법은 하기 단계를 포함하는 것이 바람직하나 이에 한정되지 않는다.Hereinafter, preferred embodiments of the manufacturing method of the present invention will be described with reference to the accompanying drawings, and the manufacturing method of the present invention preferably includes the following steps, but is not limited thereto.
본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 천연재료 추출물을 추출하는 단계(A1)와 상기 단계(A1)의 천연재료 추출물을 농축하여 천연재료 농축액을 제조하는 단계(A2)와 상기 천연재료 배합물을 건조하고 분말화하여 천연재료 분말을 제조하는 단계(B1)와 상기 단계(A2)의 천연재료 농축액과 상기 단계(B1)의 천연재료 분말을 혼합하여 과립제, 산제, 환제를 제조하는 단계(C1)를 제공한다.The present invention is to extract the natural material extract from the natural material blend consisting of chajapi, innerwear, seaweed, bale, baekbokyeong, presbytery, crust, crust, baekchul, linseed and mein (A1) and the natural of the step (A1) Concentrating the material extract to prepare a natural material concentrate (A2) and drying and powdering the natural material blend to produce a natural material powder (B1) and the natural material concentrate and the step (A2) ( Step (C1) of preparing a granule, powder, pills by mixing the natural material powder of B1).
상기 천연재료 배합물로부터 천연재료 추출물을 추출하는 단계(A1)에서 정제수와 식품용 알코올을 8 : 2 내지 5 : 5 중량비로 혼합한 추출 용매를 제조한다. 상기 식품용 알코올은 에탄올인 것이 바람직하다. In the step (A1) of extracting the natural material extract from the natural material blend, an extraction solvent is prepared by mixing purified water and food alcohol in a weight ratio of 8: 2 to 5: 5. The food alcohol is preferably ethanol.
상기 추출 용매는 알코올 대비 정제수의 중량비가 5 중량비 미만이면 알코올 성분이 상대적으로 늘어나, 추출 후 남은 알코올을 제거하기 위한 공정이 추가되며, 알코올 대비 정제수의 중량비가 8 중량비 초과이면 알코올 성분이 상대적으로 줄어 각각의 천연재료에서 추출물들이 균일하게 추출되지 않는 문제점이 있다.When the weight ratio of purified water to alcohol is less than 5 weight ratio, the extraction solvent is relatively increased alcohol component, the process for removing the remaining alcohol after extraction is added, and if the weight ratio of alcohol to purified water is more than 8 weight ratio alcohol component is relatively reduced There is a problem that the extracts are not evenly extracted from each natural material.
우선 천연재료를 깨끗이 세척하여 배합한 후, 1,000 내지 5,000 mL의 상기 추출 용매를 넣고, 75 내지 95 ℃의 온도로 8 내지 10 시간 동안 진공상태에서 천연재료 추출물을 추출하는 단계(A1)를 수행한다.First, the natural material is washed and blended, and then, 1,000 to 5,000 mL of the extraction solvent is put therein, followed by extracting the natural material extract under vacuum at a temperature of 75 to 95 ° C. for 8 to 10 hours (A1). .
상기 천연재료를 배합할 때는 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 마인 및 아마인을 포함한다.When the natural materials are blended, it includes cha-chae blood, oral gland, seaweed, bale, baekbokyeong, presbytery, jisil, crust, baekchul, mein and linseed.
상기 단계(A1)에서 상기 천연재료 추출물을 얻은 후, 상기 단계(A1)의 천연재료 추출물을 농축하는 단계(A2)를 수행한다. 1,000 내지 5,000 mL의 천연재료 추출물을 진공 저온 농축 방법으로 500 내지 1,000 mL의 혼합 천연재료 농축액을 제조한다. After obtaining the natural material extract in the step (A1), performing a step (A2) to concentrate the natural material extract of the step (A1). 500 to 1,000 mL of mixed natural material concentrate is prepared by vacuum low temperature concentration of 1,000 to 5,000 mL of natural material extract.
상기 진공 저온 농축 방법은 열 영향을 받는 물질이나 공기에 의해 산화되는 물질을 농축하기 위해 진공 상태에서 저온(40 내지 90 ℃)으로 하며, 이는 천연재료 약효의 손상없이 농축하는 것이다.The vacuum low temperature concentration method is a low temperature (40 to 90 ℃) in a vacuum state in order to concentrate the heat-affected material or the material oxidized by air, which is concentrated without damaging the natural drug effect.
다음 단계로, 상기 천연재료를 건조하고 분말화하는 단계(B1)를 수행한다. 상기 단계(B1)에서는 천연재료를 깨끗이 세척하고 배합한 후, 건조기에서 65 내지 75 ℃의 온도로 8 내지 10 시간 동안 건조한 후, 100 내지 300 mesh의 천연재료 분말을 제조한다.In the next step, the step (B1) of drying and powdering the natural material is performed. In the step (B1), after washing and blending the natural material clean, and dried in a dryer for 8 to 10 hours at a temperature of 65 to 75 ℃, to prepare a natural material powder of 100 to 300 mesh.
상기 천연재료를 배합할 때는 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 마인 및 아마인을 포함한다.When the natural materials are blended, it includes cha-chae blood, oral gland, seaweed, bale, baekbokyeong, presbytery, jisil, crust, baekchul, mein and linseed.
상기 단계(A2)에 의해 천연재료 농축액을 제조하고, 상기 단계(B1)에 의해 천연재료 분말을 제조한 후, 다음과 같이 과립제, 산제, 환제를 제조하는 단계(C1)를 수행한다.The natural material concentrate is prepared by the step (A2), the natural material powder is prepared by the step (B1), and the granules, powders and pills are prepared as follows (C1).
상기 천연재료 농축액과 부형제(옥수수 분말)를 1 : 1 내지 4 : 1 중량비로 배합한 후 동결건조로 과립제를 제조한다. 상기 부형제는 약제에 적당한 굳기나 형상을 주기 위해서 첨가하거나, 주제(主劑)의 양이 적은 경우에 일정 중량을 주어 취급하기 쉬운 크기로 할 목적으로 첨가되는 것이다. The natural material concentrate and the excipient (corn powder) are combined in a weight ratio of 1: 1 to 4: 1, and then granules are prepared by lyophilization. The said excipient is added in order to give a suitable firmness or shape to a chemical | medical agent, or it is added in order to make it easy to handle by giving a fixed weight, when the quantity of a main ingredient is small.
상기 천연재료 농축액이 부형제 대비 1 중량비 미만이면 변비 예방 및 개선의 효능이 나타나지 않으며, 부형제 대비 4 중량비를 초과하면 천연재료 농축액과 부형제가 서로 응집되는 것이 어려워 과립제 제조 시 문제점이 발생된다.If the concentration of the natural material is less than 1 weight ratio of the excipients, there is no effect of preventing and improving constipation. If the concentration exceeds 4 weight ratios of the excipients, it is difficult for the natural material concentrate and the excipient to aggregate with each other.
상기 천연재료 농축액과 천연재료 분말을 1 : 1 내지 4 : 1 중량비로 혼합하여 65 내지 75 ℃의 온도로 8 내지 10 시간 동안 건조한 후 100 내지 300 mesh의 산제를 제조한다.The natural material concentrate and the natural material powder is mixed at a weight ratio of 1: 1 to 4: 1, and dried at a temperature of 65 to 75 ° C. for 8 to 10 hours to prepare a powder of 100 to 300 mesh.
상기 산제 100 내지 400 g에 찹쌀 50 내지 450 g과 정제수 500 내지 1,500 mL를 더 포함하여 혼합하고, 3 내지 7 mm의 직경으로 환제를 제조한다. 50 to 450 g of glutinous rice and 500 to 1,500 mL of purified water are further mixed and mixed to prepare a pill with a diameter of 3 to 7 mm.
이하, 본 발명의 제조예, 실시예 및 시험예에 의해 상세히 설명한다.Hereinafter, the preparation examples, examples and test examples of the present invention will be described in detail.
하기 제조예, 실시예 및 시험예는 본 발명을 예시하는 것일 뿐, 본 발명이 하기 제조예, 실시예 및 시험예에 한정되는 것은 아니다. The following Preparation Examples, Examples, and Test Examples are merely illustrative of the present invention, and the present invention is not limited to the following Preparation Examples, Examples, and Test Examples.
< 제조예 ><Production example>
추출 용매의 제조 Preparation of Extractive Solvent
추출 용매는 정제수와 식품용 알코올(에탄올)을 7 : 3 중량비로 혼합하여 제조하였다.The extraction solvent was prepared by mixing purified water and food alcohol (ethanol) in a 7: 3 weight ratio.
< 실시예 ><Example>
변비 및 숙변 개선용 조성물의 제조 Preparation of a composition for improving constipation and stool
본 발명의 변비 및 숙변 개선용 조성물의 제조는 아래와 같은 조성물의 함량으로 혼합하여 제조하였다.Preparation of the constipation and stool improvement composition of the present invention was prepared by mixing in the content of the composition as follows.
(A1) 차전자피 33 중량%, 내복자 5 중량%, 해조 10 중량%, 곤포 10 중량%, 백복령 7 중량%, 노회 10 중량%, 지실 5 중량%, 지각 5 중량%, 백출 5 중량%, 아마인 5 중량% 및 마인 5 중량%의 천연재료를 배합한 후, 상기 제조예의 추출 용매 3,000 mL를 넣고 85 내지 90 ℃의 온도로 10 시간 동안 진공상태에서 추출하여 천연재료 추출물을 제조하였다.(A1) 33% by weight of chaff, 5% by weight of the inner wearer, 10% by weight of seaweed, 10% by weight of bale, 7% by weight of Baekbokyeong, 10% by weight of presbyopia, 5% by weight of crust, 5% by weight of crust, 5% by weight of flax After mixing 5% by weight of phosphorus and 5% by weight of natural ingredients, 3,000 mL of the extraction solvent of the preparation was added to the mixture and extracted in a vacuum at a temperature of 85 to 90 ℃ for 10 hours to prepare a natural material extract.
(A2) 상기 천연재료 추출물을 얻은 후, 3,000 mL의 상기 단계(A1)의 천연재료 추출물을 진공 저온 농축 방법으로 1,000 mL로 농축하여 천연재료 농축액을 제조하였다.(A2) After obtaining the natural material extract, 3,000 mL of the natural material extract of step (A1) was concentrated to 1,000 mL by vacuum low temperature concentration to prepare a natural material concentrate.
(B1) 차전자피 33 중량%, 내복자 5 중량%, 해조 10 중량%, 곤포 10 중량%, 백복령 7 중량%, 노회 10 중량%, 지실 5 중량%, 지각 5 중량%, 백출 5 중량%, 아마인 5 중량% 및 마인 5중량%의 천연재료를 깨끗이 씻은 후, 건조기에서 65 내지 75 ℃의 온도로 10 시간 동안 건조한 후 200 mesh 천연재료 분말을 제조하였다.(B1) 33% by weight of chaff skin, 5% by weight of the inner wearer, 10% by weight of seaweed, 10% by weight of bales, 7% by weight of Baekbokyeong, 10% by weight of presbytery, 5% by weight of crust, 5% by weight of crust, 5% by weight of flax After washing 5% by weight of phosphorus and 5% by weight of the natural material to clean, and dried for 10 hours at a temperature of 65 to 75 ℃ in a dryer to prepare a 200 mesh natural material powder.
(C1) 상기 단계(A2)의 천연재료 농축액과 옥수수 분말(부형제)을 2 : 1 중량비로 배합한 후 동결건조로 과립제를 제조하고, 상기 단계(A2)의 천연재료 농축액과 상기 단계(B1)의 천연재료 분말을 2 : 1 중량비로 혼합하여 65 내지 75 ℃의 온도로 10 시간 동안 건조한 후 200 mesh 산제를 제조하며, 상기 산제 300 g에 찹쌀 300 g과 정제수 1,000 mL를 더 포함하여 혼합한 후 5 mm의 직경으로 환제를 제조하였다.(C1) blending the natural material concentrate and corn powder (excipient) of the step (A2) in a 2: 1 weight ratio to prepare a granule by lyophilization, and the natural material concentrate of step (A2) and the step (B1) After mixing the natural material powder of 2: 1 by weight ratio and dried at a temperature of 65 to 75 ℃ for 10 hours to prepare a 200 mesh powder, 300 g of the powder and 300 ml of glutinous rice and 1,000 mL of purified water further mixed Pills were prepared with a diameter of 5 mm.
< <
시험예Test Example
> 변비 및 숙변 개선 효과 확인 > Confirm constipation and stool improvement
본 발명의 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 변비 및 숙변 개선 효과를 알아보기 위하여, 평소에 변비 증상이 있는 20~40대 남녀 20명을 대상자로 선정하고, 실험군과 대조군으로 나누어 실험하였다.In order to examine the constipation and stool improvement effect of the constipation and stool improvement composition using the natural material extract of the present invention as an active ingredient, 20 people in their 20s and 40s with constipation symptoms are selected as the subjects, the experimental group and the control group. The experiment was divided by.
실험군은 아침 및 저녁 식사 30분 전에 실시예의 조성물 4~5g을 100 mL의 물과 함께 매일 2회씩, 총 14일간 섭취하도록 하고, 상기 기간 동안 다른 변비 개선용 건강기능식품이나 약제는 섭취하지 않도록 하였다.The experimental group was ingested 4-5 g of the composition of the Example twice daily with 100 mL of water 30 minutes before breakfast and dinner, for a total of 14 days, and no other constipation-enhancing dietary supplements or drugs during this period. .
대조군은 아침 및 저녁 식사 30분 전에 100 mL의 물을 매일 2회씩, 총 14일간 섭취하도록 하고, 상기 기간 동안 다른 변비개선용 건강기능식품이나 약제는 섭취하지 않도록 하였다.The control group was ingested 100 mL of water twice daily for 14 minutes before breakfast and dinner, and no other dietary supplements or drugs for improving constipation during this period.
14일 동안 섭취한 후, 실험 대상자들에게 불규칙한 배변활동의 개선, 아랫배 복통 및 불쾌감의 개선에 대한 설문조사, 체중변화를 측정하였다. 설문조사는 5점 척도법으로 진행하였으며, 매우 좋음 5 점, 좋음 4 점, 보통 3 점, 나쁨 2 점, 매우 나쁨 1 점으로 하였다. 불규칙한 배변활동의 개선에 대한 설문조사는 14일간 배변의 횟수 및 간격에 대해 점수화하였고, 체중변화는 실시예와 비교예의 조성물을 섭취하기 전후에 몸무게를 측정하여, 섭취 전후의 몸무게 차이의 평균값을 구하여 kg으로 표기하였다. 실시예와 비교예의 조성물에 대한 평가 점수는 하기 [표 1]과 같다.After 14 days of ingestion, the subjects were weighed and surveyed for improvement in irregular bowel activity, abdominal abdominal pain and discomfort. The survey was conducted on a 5-point scale, with very good 5 points, good 4 points, moderate 3 points, bad 2 points, and very bad 1 points. The questionnaire about the improvement of irregular bowel activity was scored for the number and interval of bowel movements for 14 days, and the weight change was measured before and after ingesting the compositions of Examples and Comparative Examples, and the average value of the weight differences before and after ingestion was obtained. It is expressed in kg. Evaluation scores for the compositions of Examples and Comparative Examples are shown in Table 1 below.
| 평가항목Evaluation item | 실험군Experimental group | 대조군Control |
| 불규칙한 배변활동의 개선Improving Irregular Bowel Activity | 4.54.5 | 0.20.2 |
| 아랫배 복통 및 불쾌감의 개선Improvement of belly abdominal pain and discomfort | 4.34.3 | 0.30.3 |
| 체중감량 (kg)Weight loss (kg) | 1.71.7 | 0.10.1 |
상기 표 1에서 나타낸 바와 같이, 본 발명에 따른 변비 및 숙변 개선용 조성물을 섭취한 실험군은 불규칙한 배변활동, 아랫배 복통 및 불쾌감이 개선되고, 체중이 감량되는 결과를 보였으며, 대조군은 불규칙한 배변활동과 아랫배 복통 및 불쾌감, 체중감량에서 대체적으로 효과가 없었다. 이는 본 발명에 따른 변비 및 숙변 개선용 조성물이 배변활동과 변비를 개선하는 효과가 있으며, 숙변이 제거되어 체중감량의 효과를 나타내는 것을 확인할 수 있었다.As shown in Table 1, the experimental group ingested the composition for improving constipation and stool improvement according to the present invention showed an improvement in irregular bowel activity, lower abdominal pain and discomfort, weight loss, the control group with irregular bowel activity It was generally ineffective in belly abdominal pain, discomfort and weight loss. This was confirmed that the composition for improving constipation and stool improvement according to the present invention has the effect of improving bowel movements and constipation, stool is removed to show the effect of weight loss.
이상, 본 발명에서 설명한 것은 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물 및 그의 제조방법을 위한 실시예에 불과한 것으로, 본 발명은 상기 실시예에 한정되는 것이 아니다. 첨부된 청구범위에서 청구하는 바와 같이 본 발명의 요지를 벗어남이 없이 당해 발명이 속하는 분야에서 통상의 지식을 가진 자라면 누구든지 다양한 변경 실시가 가능한 범위까지 본 발명의 범위에 속하는 것으로 간주 되어야 할 것이다. Or more, described in the present invention is only an embodiment for the constipation and stool improvement composition and its manufacturing method using the natural ingredient extract as an active ingredient, the present invention is not limited to the above embodiment. As claimed in the appended claims, any person skilled in the art to which the present invention pertains should be regarded as falling within the scope of the present invention to the extent that various modifications can be made without departing from the gist of the present invention. .
Claims (7)
- 차전자피 15 내지 45 중량%, 내복자 1 내지 10 중량%, 해조 5 내지 30 중량%, 곤포 5 내지 30 중량%, 백복령 1 내지 7 중량%, 노회 5 내지 20 중량%, 지실 1 내지 7 중량%, 지각 1 내지 10 중량%, 백출 1 내지 7 중량%, 아마인 1 내지 7 중량% 및 마인 1 내지 7 중량%로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물로 이루어지는 것을 특징으로 하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물.15 to 45% by weight of chaff skin, 1 to 10% by weight of the inner wearer, 5 to 30% by weight of seaweed, 5 to 30% by weight of packing, 1 to 7% by weight of Baekbokyeong, 5 to 20% by weight of presbyopia, 1 to 7% by weight of silage, Natural ingredients extract, characterized in that consisting of natural ingredients extract extracted from the natural ingredients blend consisting of 1 to 10% by weight, 1 to 7% by weight, 1 to 7% by weight of flax seeds and 1 to 7% by weight of mine Constipation and stool improvement composition to.
- 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 천연재료 추출물을 추출하는 단계(A1);Extracting a natural material extract from a natural material blend consisting of cha-e-p, pilgrimage, seaweed, bale, baekbok-ryong, presbytery, jisil, crust, baekchul, linseed, and mein (A1);상기 단계(A1)의 천연재료 추출물을 농축하여 천연재료 농축액을 제조하는 단계(A2); 및 Concentrating the natural material extract of step (A1) to produce a natural material concentrate (A2); And상기 단계(A2)의 천연재료 농축액과 옥수수 분말을 배합한 후 동결건조로 과립제를 제조하는 단계(C1)을 포함하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법.Method of producing a composition for improving constipation and stool, using the natural material extract comprising the step (A1) and the natural powder extract (C1) after mixing the natural powder concentrate and corn powder to prepare a granule by lyophilization.
- 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 천연재료 추출물을 추출하는 단계(A1);Extracting a natural material extract from a natural material blend consisting of cha-e-p, pilgrimage, seaweed, bale, baekbok-ryong, presbytery, jisil, crust, baekchul, linseed, and mein (A1);상기 단계(A1)의 천연재료 추출물을 농축하여 천연재료 농축액을 제조하는 단계(A2);Concentrating the natural material extract of step (A1) to produce a natural material concentrate (A2);상기 천연재료 배합물을 건조하고 분말화하여 천연재료 분말을 제조하는 단계(B1); 및Drying and powdering the natural material blend to produce a natural material powder (B1); And상기 단계(A2)의 천연재료 농축액과 상기 단계(B1)의 천연재료 분말을 혼합하여 산제, 또는 산제의 가공공정을 거친 환제를 제조하는 단계(C1)를 포함하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법.Mixing the natural material concentrate of the step (A2) and the natural material powder of the step (B1) to prepare a powder or a pill after a powder processing step (C1) as an active ingredient Method of producing a composition for improving constipation and stool.
- 제 2 항 또는 제 3 항에 있어서,The method of claim 2 or 3,상기 천연재료 추출물을 추출하는 단계(A1)에서 정제수와 식품용 에탄올을 8 : 2 내지 5 : 5 중량비로 혼합한 추출 용매를 사용하는 것을 특징으로 하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법.Constipation and stool improvement using the natural material extract as an active ingredient, characterized in that using the extraction solvent mixed with purified water and food ethanol in a weight ratio of 8: 2 to 5: 5 in the step (A1) extracting the natural material extract Method for producing a composition for.
- 제 2 항에 있어서,The method of claim 2,상기 단계(A2)의 천연재료 농축액과 옥수수 분말을 1 : 1 내지 4 : 1 중량비로 배합한 후 동결건조로 과립제를 제조하는 것을 특징으로 하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법.Constipation and stool improvement composition comprising a natural material extract as an active ingredient, characterized in that the granules are prepared by lyophilization after mixing the natural material concentrate and corn powder of the step (A2) in a weight ratio of 1: 1 to 4: 1. Manufacturing method.
- 제 3 항에 있어서,The method of claim 3, wherein상기 단계(A2)의 천연재료 농축액과 상기 단계(B1)의 천연재료 분말을 혼합하여 65 내지 75 ℃의 온도로 건조한 후 산제를 제조하는 것을 특징으로 하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법.Constipation and stool with natural ingredients extract as an active ingredient, characterized in that to prepare a powder after drying at a temperature of 65 to 75 ℃ by mixing the natural material concentrate of the step (A2) and the natural material powder of the step (B1) Method for producing a composition for improvement.
- 제 6 항에 있어서,The method of claim 6,상기 산제에 찹쌀과 정제수를 더 포함하여 혼합한 후 3 내지 7 mm의 직경으로 환제를 제조하는 것을 특징으로 하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법.Method of producing a composition for improving constipation and stool with natural ingredients extracts, characterized in that to produce a pill with a diameter of 3 to 7 mm after mixing further comprising glutinous rice and purified water in the powder.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020160097064A KR101687558B1 (en) | 2016-07-29 | 2016-07-29 | A composition containing natural materials extract as an active ingredient for treatment of constipation, and manufacturing method of the same |
| KR10-2016-0097064 | 2016-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2018021891A1 true WO2018021891A1 (en) | 2018-02-01 |
Family
ID=57735283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2017/008207 WO2018021891A1 (en) | 2016-07-29 | 2017-07-31 | Composition containing natural material extract as active ingredient for alleviating constipation and coprostasis and preparation method therefor |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR101687558B1 (en) |
| WO (1) | WO2018021891A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102658628B1 (en) * | 2023-04-28 | 2024-04-19 | 노비스바이오 주식회사 | Functional composition containing sugar coated psyllium hull powder |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101687558B1 (en) * | 2016-07-29 | 2016-12-19 | 천지인초 주식회사 | A composition containing natural materials extract as an active ingredient for treatment of constipation, and manufacturing method of the same |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020037653A (en) * | 2000-11-15 | 2002-05-22 | 양광승 | Supplements for Health Supplements |
| KR20050112941A (en) * | 2004-05-28 | 2005-12-01 | 주식회사 바이웰 | Composition for constipation improvement |
| KR20140121988A (en) * | 2013-04-09 | 2014-10-17 | 박용식 | cleaning the chapter |
| KR20160037510A (en) * | 2014-09-29 | 2016-04-06 | 김구환 | Fermented foods improve bowel function and a method of manufactuing stercoral removal efficacy |
| KR101687558B1 (en) * | 2016-07-29 | 2016-12-19 | 천지인초 주식회사 | A composition containing natural materials extract as an active ingredient for treatment of constipation, and manufacturing method of the same |
-
2016
- 2016-07-29 KR KR1020160097064A patent/KR101687558B1/en active IP Right Grant
-
2017
- 2017-07-31 WO PCT/KR2017/008207 patent/WO2018021891A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020037653A (en) * | 2000-11-15 | 2002-05-22 | 양광승 | Supplements for Health Supplements |
| KR20050112941A (en) * | 2004-05-28 | 2005-12-01 | 주식회사 바이웰 | Composition for constipation improvement |
| KR20140121988A (en) * | 2013-04-09 | 2014-10-17 | 박용식 | cleaning the chapter |
| KR20160037510A (en) * | 2014-09-29 | 2016-04-06 | 김구환 | Fermented foods improve bowel function and a method of manufactuing stercoral removal efficacy |
| KR101687558B1 (en) * | 2016-07-29 | 2016-12-19 | 천지인초 주식회사 | A composition containing natural materials extract as an active ingredient for treatment of constipation, and manufacturing method of the same |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102658628B1 (en) * | 2023-04-28 | 2024-04-19 | 노비스바이오 주식회사 | Functional composition containing sugar coated psyllium hull powder |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101687558B1 (en) | 2016-12-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104524110A (en) | Traditional Chinese medicine composition with functions of tonifying spleen and clearing damp | |
| CN105166544A (en) | Pig mixed feed and preparation method thereof | |
| KR101632794B1 (en) | METHOD OF MANUFACTURING PILL COMPRISED OF Protaetia brevitarsis seulensis | |
| WO2016163652A1 (en) | Health supplement food for promotion of hair growth, mitigation and alleviation of hair loss, regulation of blood glucose, and alleviation and relief of gastric disorder symptoms | |
| WO2018021891A1 (en) | Composition containing natural material extract as active ingredient for alleviating constipation and coprostasis and preparation method therefor | |
| CN106173450A (en) | Improve compound feed additive and the feedstuff of pigeon immunity | |
| WO2016006852A1 (en) | Functional coffee containing medicinal herb and preparation method therefor | |
| CN105028995A (en) | Mixed dog food and preparation method thereof | |
| KR100376307B1 (en) | Healthy food composition for preventing and treatmenting constipation | |
| CN104001045A (en) | Drug for treating dog pneumonia and preparation method thereof | |
| KR101711018B1 (en) | Chinese medicine for treating children constipation | |
| CN100509041C (en) | Stomach-clearing pill | |
| CN103239667A (en) | Chinese traditional medicine for treating foot-and-mouth disease of domestic animals | |
| KR100522176B1 (en) | Composition for improving male sexual function | |
| CN110025737A (en) | Probiotics fermention loquat composition and preparation method thereof | |
| CN103211988B (en) | Pharmaceutical composition for treating porcine infectious gastrointestinal inflammations | |
| CN1299755C (en) | Cinnamon compound medicine, and its preparing method and use | |
| CN116370574B (en) | Traditional Chinese medicine composition for preventing and treating gosling gout and preparation method thereof | |
| CN106620397A (en) | Granules capable of preventing and treating dental ulcer and preparation method of granules | |
| KR100497845B1 (en) | food having herbal medicine for assisting healthy and producing method thereof | |
| CN105168709A (en) | Traditional Chinese medicine composition for treating stomach distension | |
| KR20230106980A (en) | Composition for preventing, improving or treating constipation comprising extract of Plantago asiatica | |
| CN103948840A (en) | Traditional Chinese medicine additive for treating swine allotriophagia and preparation method thereof | |
| CN104352606A (en) | Preparation for treating esophagus cancer in mode of combating poison with poison and preparation method of preparation | |
| CN111406921A (en) | Medicinal and edible gastrointestinal food for maintaining homology of medicine and food |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 17834831 Country of ref document: EP Kind code of ref document: A1 |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 32PN | Ep: public notification in the ep bulletin as address of the adressee cannot be established |
Free format text: NOTHING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC, (EPO FORM 1205A DATED 27.05.19) |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 17834831 Country of ref document: EP Kind code of ref document: A1 |