CN104524110A - Traditional Chinese medicine composition with functions of tonifying spleen and clearing damp - Google Patents
Traditional Chinese medicine composition with functions of tonifying spleen and clearing damp Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition with functions of tonifying spleen and clearing damp. The bulk drugs of the traditional Chinese medicine composition comprise semen coicis, phaseolus calcaratus, gorgon fruit, Chinese yam and semen armeniacae amarae and also can comprise pogostemon cablin and honeysuckle. Clinical observation indicates that the traditional Chinese medicine composition has the functions of nourishing the stomach and spleen, clearing damp and heart, adjusting inclined damp and hot corporeity, and obviously tonifying spleen and clearing damp. The traditional Chinese medicine composition has the advantages that the medicine is convenient to take, the requirements of fast-pace life of modern people are met, and the medicine is safe and effective without any toxic and side effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition with invigorating the spleen to clear away damp pathogen effect.
Background technology
South China is Lingnan area especially, summer duration, how damp and hot water and soil is.People live in hygrothermal environment for a long time, the common damp-heat constitution of sub-health state.Damp-heat constitution take retention of damp-heat in the interior as the constitution status of principal character.Its origin cause of formation is many owing to living in hygrothermal environment for a long time, and spleen is originally subject to wet tired, in addition or addicted to tobacco and wine, often stay up late, or long-term emotion is constrained, or cloudy soft many wet things such as many greedy cool cold drink, polyphagia fish and shrimp etc., or eats well delicious food; Thus cause water wet invasion human body, thus spleen transportation capabilities are obstructed or dysfunction of the spleen, and water humidity hysteresis stays, and causes wet from interior life.Meet extraneous damp and hot heresy again and cause burning hot in accumulate, formation damp-heat constitution.
Damp-heat constitution patient clinical, with burnt in retention of damp-heat in the interior, hinders caused by taste mechanism of qi particularly common.Its main manifestations has: face jaundice, obfuscation, greasy, easy long pox on the face, congestion and swelling pain is comparatively obvious; Health is sleepy, heavy, and asthenia is unable, fatiguability, sore waist and aching in the waist and the back; Appetite is bad, anorexia of easily feeling sick, uncomfortable in chest, thirstyly does not want to drink water; Yellowish fur, easy bitter taste xerostomia, there is abnormal flavour in oral cavity; Stool viscous is not smooth, can't is washed off, pastes toilet with water punching; Women, be then shown in the many and jaundice of leucorrhea, male's then easy dampness of scrotum.And the course of disease is comparatively of a specified duration, more, easy recurrent exerbation, has a strong impact on the quality of life of patient to the touching difficulty of patient's condition.
Damp and hot treatment, generally will divide weight in wet base or thermogravimetric.The treatment of weight in wet base is based on removing dampness; Thermogravimetric is then based on heat clearing away.Some herbal tea in the market, as " the old herbal tea of Deng " series of products five flower damp eliminating tea and removing toxic substances are relieved summer heat tea, are main mainly with heat clearing away.But too heat clearing away and not heavily damp eliminating, the essential reason of retention of dampness in middle-JIAO still exists, then damp-heat constitution can not obtain basic improvement.
Qing Dynasty's Wu Ju Tong show a famous prescription " sanren decoction " in " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases ", be mainly used in treatment hygropyrexia from the beginning of, evil in edema caused by disorder of QI, weight in wet base is in the disease of heat.Sanren decoction by Semen Armeniacae Amarum, roud cardamon seed, Semen Coicis, fly Talcum, Folium Bambusae, white Medulla Tetrapanacis, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis eight taste medicine form.Embody a surname upper, smooth in, ooze under, three burnt points of compatible experiments disappeared, gas is wet row freely, then three is burnt unobstructed.Wu's a kind of jade is from noting: " only gently open part of the body cavity above the diaphragm housing the heart and lungs lung qi with sanren decoction, lid the lung is concerned with QI of the whole body, gasification is then wet also to be changed also.”
But " sanren decoction " is mainly as drug use, should not take in a large number for a long time.The southern area such as Guangdong and Guangxi Provinces, Hainan people live in hygrothermal environment for a long time, because the environment of life can not change, therefore the sub-health population of this area based on damp-heat constitution is badly in need of a kind of Chinese medicine composition being suitable for daily health care, can taking in a large number for a long time.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition with invigorating the spleen to clear away damp pathogen effect.Chinese medicine composition of the present invention, for damp-heat constitution feature, rationally multiple integration of edible and medicinal herbs composition, has the effect of taking good care of taste, regulating the flow of Qi and the middle Jiao, damp eliminating heat clearing away, can regulate total balance of the body, alleviate damp and hot associated disease symptom, and safe and effective, have no side effect, delicious taste, not containing any chemosynthesis additive, can long-term taking.
In order to realize foregoing invention object, the present invention by the following technical solutions.
A Chinese medicine composition for invigorating the spleen to clear away damp pathogen, the crude drug of described Chinese medicine composition comprises: Semen Coicis 2-8 weight portion, Semen Phaseoli 2-8 weight portion, Semen Euryales 1-5 weight portion, Rhizoma Dioscoreae 1-5 weight portion, Semen Armeniacae Amarum 0.5-3 weight portion.
Preferably, the crude drug of above-mentioned Chinese medicine composition comprises: Semen Coicis 3-7 weight portion, Semen Phaseoli 3-7 weight portion, Semen Euryales 2-4 weight portion, Rhizoma Dioscoreae 1-3 weight portion, Semen Armeniacae Amarum 1-2 weight portion.
More preferably, the crude drug of above-mentioned Chinese medicine composition comprises: Semen Coicis 4-6 weight portion, Semen Phaseoli 4-6 weight portion, Semen Euryales 2.5-3.5 weight portion, Rhizoma Dioscoreae 1.5-2.5 weight portion, Semen Armeniacae Amarum 1.3-1.7 weight portion.
Preferably, the crude drug of Chinese medicine composition of the present invention can also comprise: Herba Pogostemonis 0.1-3 weight portion, Flos Lonicerae 0.1-3 weight portion.
More preferably, the crude drug of Chinese medicine composition of the present invention can also comprise: Herba Pogostemonis 0.5-1.5 weight portion, Flos Lonicerae 0.5-1.5 weight portion.
Further preferably, the crude drug of Chinese medicine composition of the present invention can also comprise: Herba Pogostemonis 0.5-0.8 weight portion, Flos Lonicerae 0.4-0.6 weight portion.
As one preferred embodiment, the invention provides a kind of Chinese medicine composition of invigorating the spleen to clear away damp pathogen, consisting of of crude drug:
Semen Coicis 3-7 weight portion, Semen Phaseoli 3-7 weight portion, Semen Euryales 2-4 weight portion, Rhizoma Dioscoreae 1-3 weight portion, Semen Armeniacae Amarum 1-2 weight portion, Herba Pogostemonis 0.5-1.5 weight portion, Flos Lonicerae 0.5-1.5 weight portion.
As a preferred embodiment, the invention provides a kind of Chinese medicine composition of invigorating the spleen to clear away damp pathogen, consisting of of crude drug:
Semen Coicis 4-6 weight portion, Semen Phaseoli 4-6 weight portion, Semen Euryales 2.5-3.5 weight portion, Rhizoma Dioscoreae 1.5-2.5 weight portion, Semen Armeniacae Amarum 1.3-1.7 weight portion, Herba Pogostemonis 0.5-0.8 weight portion, Flos Lonicerae 0.4-0.6 weight portion.
As a further preferred embodiment, the invention provides a kind of Chinese medicine composition of invigorating the spleen to clear away damp pathogen, consisting of of crude drug:
Semen Coicis 4430 grams, Semen Phaseoli 4430 grams, Semen Euryales 2650 grams, Rhizoma Dioscoreae 1770 grams, Semen Armeniacae Amarum 1330 grams, Herba Pogostemonis 500 grams, Flos Lonicerae 440 grams.
Preferably, Chinese medicine composition of the present invention, also comprises pharmaceutically acceptable adjuvant, makes acceptable oral formulations clinically.
Preferably, described oral formulations is selected from capsule, tablet, granule, oral solution or oral liquid.
Another object of the present invention is the preparation method providing above-mentioned Chinese medicine composition, comprises the steps:
Each crude drug is taken by formula, mixing, rinses crude drug with water, and 40-50 DEG C of water 400-500 weight portion soaks 2-3 hour, be heated to boiling, then keep slight boiling condition 2-3 hour, filter, preferably filter with 100-250 order stainless steel filtering net, filtrate concentrates, drying, adds pharmaceutically acceptable adjuvant, makes described oral formulations.
As one preferred embodiment, the invention provides the preparation method of described Chinese medicine composition, wherein said Chinese medicine composition is oral solution, and preparation method comprises the steps:
1) each crude drug is taken by formula;
2) 500 weight portions that first added water by Semen Phaseoli decoct, and keep micro-and boil 2-3 hour, filter, preferably filter with 100-250 order stainless steel filtering net, obtain Semen Phaseoli filtrate and Semen Phaseoli slag after water boils, for subsequent use respectively;
3) each for all the other except Semen Phaseoli crude drug 40-50 DEG C of water 40-60 weight portion is soaked 2-3 hour, be dosed in decoction pot, then add the Semen Phaseoli slag and water 80-120 weight portion that step 2 obtains, be heated to boiling, then keep slight boiling condition 2-3 hour, filter, filtrate adds the Semen Phaseoli water that step 2 obtains, stir, make to be uniformly dispersed, filter, filter preferably by the flame filter press of 0.8 μm, sterilizing, obtains described oral solution.
In the preparation method of above-mentioned oral solution, in described step 3, after described filtrate adds described Semen Phaseoli water, before filtration, correctives can be added; Preferably add stevioside or white sugar, more preferably add 2-20 weight portion white sugar.
A further object of the invention is to provide a kind of Chinese medicine composition, and described Chinese medicine composition is prepared by above-mentioned preparation method.
The present invention also provides a kind of liquid beverage, and described liquid beverage is prepared by the preparation method of above-mentioned oral solution.
A further object of the invention is to provide above-mentioned Chinese medicine composition and the application of aforesaid liquid beverage in the medicine preparing the effect of tool invigorating the spleen to clear away damp pathogen.
Pharmaceutically acceptable adjuvant of the present invention, comprising: 1) filler/diluent, such as, can be selected from water, starch, pregelatinized Starch, Icing Sugar, dextrin, lactose, microcrystalline cellulose, inorganic calcium salt, sugar alcohols etc.; 2) wetting agent and binding agent, such as, can be selected from water, ethanol, starch slurry, dextrin, Icing Sugar and syrup, rubber cement, polyethylene glycols, cellulose derivative etc.; 3) disintegrating agent, such as, can be selected from dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose etc.; 4) lubricant, such as, can be selected from magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol and magnesium laurylsulfate etc.; 5) coating material, such as, can be selected from cellulose family etc.; 6) correctives, such as, can be selected from stevioside, white sugar, aspartame etc.
" water " in description of the present invention, does not have specified otherwise, refers to " distilled water ".
Below respectively the function of each composition of said composition is discussed:
Semen Coicis: be the dry mature kernal of grass Semen Coicis (Coix lacryma-jobi L.).Sweet, light, cool.Return spleen, stomach, lung meridian.There is promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, eliminating impediment, evacuation of pus, effect of detoxicating and resolving stagnation of pathogens.Burnt damp and hot for three, insufficiency of the spleen diarrhoea, lung-heat lung abscess etc.
Semen Phaseoli: be the dry mature seed of leguminous plant Semen Phaseoli (Vigna umbeuata).Sweet, sour, flat.GUIXIN, small intestine meridian.There is effect of inducing diuresis to remove edema, removing toxic substances and promoting pus discharge.Compendium of Material Medica: " Semen Phaseoli, under its property, logical small intestinal, can enter cloudy point, therefore promoting circulation of body fluid diuresis, relieving distension is except swollen." modern study shows, the nutrient such as its rich in proteins, saccharide, fat, dietary fiber, vitamin B group, vitamin E, potassium, calcium, ferrum, phosphorus, zinc.
Semen Euryales: be the dry mature kernal of nymphaeaceae plant Gorgon euryale (Euryale ferox).Sweet, puckery, flat.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, effect of eliminating dampness and arresting leucorrhea.Modern study shows, Semen Euryales contains a large amount of nutrient useful to human body, as protein, calcium, phosphorus, ferrum, fat, carbohydrate, vitamin B1, B2, C, crude fibre, carotene etc., and easily digests.
Rhizoma Dioscoreae: be the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae (Dioscorea opposita Thunb.).Sweet, flat.Return spleen, lung, kidney channel.There is spleen reinforcing nourishing the stomach, effect of the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Rhizoma Dioscoreae is also containing soluble fiber, and deferrable gastric food emptying, controls blood glucose after meal and raise, contribute to digestion, blood sugar lowering.Secondly, Rhizoma Dioscoreae is a kind of high nutrition, food low in calories inherently, can eat relievedly and not have the trouble and worry of getting fat.
Semen Armeniacae Amarum: be the dry mature seed of rosaceous plant Prunus armeniaca L.var.ansu Maxim. (Prunus armeniaca L.).Bitter, tepor.Return lung, large intestine channel.There is sending down the abnormal ascending QI relieving cough and asthma, effect of loosening bowel to relieve constipation.
Herba Pogostemonis: be the dry aerial parts of labiate Herba Pogostemonis (Pogostemon cablin).Pungent, tepor.Return spleen, stomach, lung meridian.There is eliminating turbid pathogen with aromatics and middle preventing or arresting vomiting, deliver effect of expelling summer-heat.
Flos Lonicerae: the flower that dry flower or band for caprifoliaceae plant Radix Ophiopogonis (Lonicera japonica Thunb.) are just opened.Sweet, cold.Return lung, the heart, stomach warp.There is heat-clearing and toxic substances removing, effect of dispelling wind and heat pathogens.
Various crude drug in Chinese medicine composition of the present invention all can be bought from market, the regulation that product quality meets " version Chinese Pharmacopoeia in 2010 ".
Beneficial effect of the present invention:
The present invention uses Chinese medical theory to be guidance, adopts the frame structure of Chinese medicine " monarch, minister, help, make ", and does in conjunction with modern's damp-heat constitution caused by the southern damp and hot weather such as Guangdong and Guangxi Provinces, Hainan.We are the card of damp and hot, deficiency-weakness of spleen-QI light from the beginning of, weight in wet base heat and establishing.In side with Semen Coicis, Semen Phaseoli, Semen Euryales damp eliminating for monarch drug.Wherein cold, the dampness removing of Semen Coicis slightly sweet flavor and spleen invigorating, dredge the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, make damp and hot going from urine, under namely this ooze; Semen Phaseoli inducing diuresis to remove edema, spleen invigorating and reinforcing the heart; Semen Euryales damp eliminating, circulation of qi promoting are fallen apart full, to strengthen the male power of removing dampness in fortune.Be aided with Semen Armeniacae Amarum, the power of Herba Pogostemonis cough-relieving removing dampness by means of aromatics is ministerial drug.Wherein Semen Armeniacae Amarum toil declare smooth part of the body cavity above the diaphragm housing the heart and lungs lung qi, gasification is then wetly also changed, dredge that profit is opened, cough-relieving detumescence and moisturizing; Herba Pogostemonis has removing dampness by means of aromatics, expelling summer-heat is delivered and the merit of middle preventing or arresting vomiting, both can change at inner turbid damp, again can solution in the heat-damp in summer of table.Help and grow essence with Chinese yam spleen-strengtheningporridge tonify deficiency and reinforce the kidney, both can the gas of tonifying the lung spleen, the moon of lung benefiting kidney again.Make with steam in Flos Lonicerae clearing away heat and expelling pathogen in the exterior, body of dispelling.All medicines share above, gather the merit of damp eliminating spleen invigorating, cough-relieving, clearing away heat and expelling pathogen in the exterior altogether, and be that treatment is damp and hot, southern especially coastal cities humid day conductance causes the damp and hot good recipe of body constitution.
Chinese medicine composition of the present invention, significantly can improve the symptom of syndrome of dampness-heat of spleen and stomach rat model.Clinical experiment also proves, Chinese medicine composition of the present invention can adjust inclined damp-heat constitution, invigorating the spleen to clear away damp pathogen Be very effective.
Chinese medicine composition of the present invention has no side effect safely." being food and the article of medicine " of all announcing with Ministry of Public Health, for raw material, raw material is common and be easy to get, and suitable long-term edible, safety has no side effect.
Chinese medicine composition of the present invention, can be made into beverage, takes very convenient, meets the fast pace life requirement of modern, and safe and effective, without any side effects.
Compositions of the present invention, preparation method technique is simple, easy to operate, is applicable to commercial production.
Detailed description of the invention
Further illustrate the present invention below by way of specific embodiment, but following examples are only for illustration of the present invention but not for limiting the present invention.
Experimental technique in following embodiment, if no special instructions, is conventional method.Raw material used in following embodiment, reagent material etc., if no special instructions, be commercially available purchase product.Product quality is as the criterion with " version Chinese Pharmacopoeia in 2010 " standard.
embodiment 1a kind of Chinese medicine capsules of invigorating the spleen to clear away damp pathogen
Crude drug consists of:
Semen Coicis 6195g Semen Phaseoli 2650g Semen Euryales 3540g
Rhizoma Dioscoreae 885g Semen Armeniacae Amarum 885g
Preparation method: put into decoction pot by through the above medical material selecting and rinse, the warm water 442.5kg adding 50 DEG C soaks 2 hours, is heated to boiling, then keeps slight boiling condition 2 hours at 98 DEG C-101 DEG C.Decocting liquid is filtered 100 order stainless steel filtering nets.Decoction liquor density is 1.085 (40 DEG C), pH=6.31.Through concentrated, drying under reduced pressure, is ground into dry extract, adds adjuvant, dry extract weight and adjuvant gross weight are than being 9:1, adjuvant consists of: magnesium stearate: micropowder silica gel: starch: crosslinked carboxymethyl fecula sodium=1:2:6:1, and mixing, loads No. 0 capsule, the loading amount of single capsule is 0.5g (nt wt net weight), wherein dry extract net weight is 0.45g, and every capsules its content is equivalent to 3g crude drug amount, obtains target Chinese medicine capsules.
Consumption usage: every day 1 time, each 5.
embodiment 2a kind of Chinese medicinal tablet of invigorating the spleen to clear away damp pathogen
Crude drug forms:
Semen Coicis 2650g Semen Phaseoli 6195g Semen Euryales 1770g
Rhizoma Dioscoreae 2650g Semen Armeniacae Amarum 1770g
Preparation method: put into decoction pot by through the above medical material selecting and rinse, the warm water 442.5kg adding 40 DEG C soaks 3 hours, is heated to boiling, then keeps slight boiling condition 3 hours at 98 DEG C-101 DEG C.Decocting liquid is filtered 200 order stainless steel filtering nets.Decoction liquor density is 1.024 (40 DEG C), pH=6.16.Through concentrated, drying under reduced pressure is dry extract, add lactose (dry extract and lactose weight ratio are 3:7) and granule made by appropriate 90%-95% ethanol (volumn concentration), dry granule adds magnesium stearate and polyvinylpolypyrrolidone (granule gross weight: magnesium stearate weight: polyvinylpolypyrrolidone weight=98:1:1), tabletting after mixing, every sheet weighs 0.5 gram, obtains described target tablet, every sheet, containing dry extract net weight 0.15g, is equivalent to crude drug amount 1g.
Consumption usage: every day 3 times, each 5.
embodiment 3a kind of Chinese medicine granules of invigorating the spleen to clear away damp pathogen
Crude drug forms:
Semen Coicis 7080g Semen Phaseoli 1770g Semen Euryales 4430g
Rhizoma Dioscoreae 885g Semen Armeniacae Amarum 440g
Preparation method: put into decoction pot by through the above medical material selecting and rinse, the warm water 354kg adding 45 DEG C soaks 3 hours, is heated to boiling, then keeps slight boiling condition 2 hours at 98 DEG C-101 DEG C.Decocting liquid is filtered 250 order stainless steel filtering nets.Decoction liquor density is 1.011 (40 DEG C), pH=5.97.Through concentrated, drying under reduced pressure is dry extract, add dextrin (dry extract and dextrin weight ratio are 2:3) to mix, granulate with appropriate 85% ethanol (volumn concentration) moistening, wet grain drying, moisture Control is below 2%, granulate, subpackage, every bag of 5.5g, obtains target particles agent; Every 1g, containing dry extract 0.4g, is equivalent to crude drug amount 2.7g.
Consumption usage: once a day, each 1 bag.
embodiment 4a kind of invigorating the spleen to clear away damp pathogen liquid beverage
Crude drug forms:
Semen Coicis 4430g Semen Phaseoli 4430g Semen Euryales 2650g
Rhizoma Dioscoreae 1770 Semen Armeniacae Amarum 1330g
Preparation method:
Put into decoction pot by through the Semen Phaseoli selecting and rinse, add water 442.5kg, is heated to boiling, then keeps slight boiling condition 2.5 hours at 98 DEG C-101 DEG C.Decocting liquid is filtered 250 order stainless steel filtering nets, obtain Semen Phaseoli water 265.5kg, density is 0.96 (40 DEG C), pH=6.77.The another device of Semen Phaseoli slag is collected.
By the residue medical material except Semen Phaseoli, with the warm water 44kg of 50 DEG C, soak 2 hours, be dosed in decoction pot, the Semen Phaseoli slag upper step obtained adds, then the 88.5kg that adds water, and is heated to boiling, and then 98-101 DEG C keeps slight boiling condition 2 hours.Decoction liquor filtered, being concentrated into density is 1.02 (40 DEG C), detects pH=5.83.The Semen Phaseoli water upper step obtained adds filtrate, stirs and makes to be uniformly dispersed, be then transferred in Agitation Tank, add 4430g white sugar, stir 30 minutes, and detect pH=6.22, density is: 1.01 (40 DEG C).Then filtered by the flame filter press of feed liquid by 0.8 μm, proceed to fluid reservoir, two panels aluminium pot is filled with nitrogen, tinning, every canned 310ml, and sterilizing, obtains target liq beverage.
embodiment 5a kind of invigorating the spleen to clear away damp pathogen liquid beverage
Crude drug forms:
Semen Coicis 1770g Semen Phaseoli 7080g Semen Euryales 885g
Rhizoma Dioscoreae 4430g Semen Armeniacae Amarum 885g
Preparation method:
Put into decoction pot by through the Semen Phaseoli selecting and rinse, add water 354kg, is heated to boiling, then keeps slight boiling condition 2.5 hours at 98 DEG C-101 DEG C.By decocting liquid, filter 250 order stainless steel filtering nets, obtain Semen Phaseoli water 265.5kg, density is 0.98 (40 DEG C), pH=6.83.The another device of Semen Phaseoli slag is collected.
By the warm water 44kg of the residue medical material except Semen Phaseoli with 40 DEG C, soak 3 hours, be dosed in decoction pot, the Semen Phaseoli slag upper step obtained adds, then the 88.5kg that adds water, and is heated to boiling, and then 98-101 DEG C keeps slight boiling condition 3 hours.Decoction liquor filtered, being concentrated into density is 1.08 (40 DEG C), detects pH=5.94.The Semen Phaseoli water upper step obtained adds filtrate, stirs and makes to be uniformly dispersed, be then transferred in Agitation Tank, stir 30 minutes, and detect pH=6.27, density is: 1.03 (40 DEG C).Then filtered by the flame filter press of feed liquid by 0.8 μm, proceed to fluid reservoir, load can, every canned 310ml, sterilizing, obtains target liq beverage.
embodiment 6a kind of Chinese medicine capsules of invigorating the spleen to clear away damp pathogen
Crude drug forms:
Semen Coicis 5310g Semen Phaseoli 3540g Semen Euryales 1770g
Rhizoma Dioscoreae 1770g Semen Armeniacae Amarum 885g Herba Pogostemonis 440g
Flos Lonicerae 1330g
Preparation method: the Semen Coicis through selecting and rinsing, Semen Phaseoli, Semen Armeniacae Amarum, Rhizoma Dioscoreae and Semen Euryales are put into decoction pot, the warm water 442.5kg adding 50 DEG C soaks 2 hours, then Herba Pogostemonis and Flos Lonicerae is added, soak after 1 hour, be heated to boiling, keep slight boiling condition at 98 DEG C-101 DEG C 2 hours.By decocting liquid, filter 250 order stainless steel filtering nets.Decoction liquor density is 1.005 (40 DEG C), pH=6.21.Through concentrated, drying under reduced pressure, be ground into dry extract, add adjuvant, dry extract weight and adjuvant gross weight are than being 9:1, adjuvant consists of: magnesium stearate: micropowder silica gel: starch: crosslinked carboxymethyl fecula sodium=1:2:6:1 (weight proportion) mixes, load No. 0 capsule, the loading amount of single capsule is 0.5g, wherein containing dry extract 0.45g, every capsules its content is equivalent to 3g crude drug amount, obtains target Chinese medicine capsules.
Consumption usage: every day 1 time, each 5.
embodiment 7a kind of Chinese medicinal tablet of invigorating the spleen to clear away damp pathogen
Crude drug forms:
Semen Coicis 3540g Semen Phaseoli 5310g Semen Euryales 2650g
Rhizoma Dioscoreae 1770g Semen Armeniacae Amarum 440g Herba Pogostemonis 1330g
Flos Lonicerae 440g
Preparation method: the Semen Coicis through selecting and rinsing, Semen Phaseoli, Semen Armeniacae Amarum, Rhizoma Dioscoreae and Semen Euryales are put into decoction pot, the warm water 442.5kg adding 40 DEG C soaks 3 hours, then Herba Pogostemonis and Flos Lonicerae is added, soak after 1 hour, be heated to boiling, keep slight boiling condition at 98 DEG C-101 DEG C 3 hours.By decocting liquid, filter 200 order stainless steel filtering nets.Decoction liquor density is 1.028 (40 DEG C), pH=6.18.Through concentrated, drying under reduced pressure is dry extract, add lactose (extractum and lactose weight ratio are 3:7) and granule made by appropriate 90%-95% ethanol (volumn concentration), dry granule adds magnesium stearate and polyvinylpolypyrrolidone (granule gross weight: magnesium stearate weight: polyvinylpolypyrrolidone weight=98:1:1), tabletting after mixing, the heavy 0.5g of every sheet, every sheet, containing dry extract 0.15g, is equivalent to crude drug amount 1g.
Consumption usage: every day 3 times, each 5.
embodiment 8a kind of granule of invigorating the spleen to clear away damp pathogen
Crude drug forms:
Semen Coicis 4430g Semen Phaseoli 4430g Semen Euryales 885g
Rhizoma Dioscoreae 2650g Semen Armeniacae Amarum 1330g Herba Pogostemonis 90g
Flos Lonicerae 2650g
Preparation method: the Semen Coicis through selecting and rinsing, Semen Phaseoli, Semen Armeniacae Amarum, Rhizoma Dioscoreae and Semen Euryales are put into decoction pot, the warm water 442.5kg adding 45 DEG C soaks 2.5 hours, then Herba Pogostemonis and Flos Lonicerae is added, soak 1 hour, be heated to boiling, keep slight boiling condition at 98 DEG C-101 DEG C 2 hours.By decocting liquid, filter 100 order stainless steel filtering nets.Decoction liquor density is 1.021 (40 DEG C), pH=6.04.Through concentrated, drying under reduced pressure is extractum, adds dextrin mixing (extractum and dextrin weight ratio are 2:3), granulates with 85% ethanol (volumn concentration) moistening, wet grain drying, moisture Control below 2%, granulate, subpackage, every bag of 5.5g, obtains target particles agent.Every 1g granule, containing dry extract 0.4g, is equivalent to crude drug amount 2.7g.
Consumption usage: once a day, each 1 bag.
embodiment 9a kind of invigorating the spleen to clear away damp pathogen liquid beverage
Crude drug forms:
Semen Coicis 4430g Semen Phaseoli 4430g Semen Euryales 1770g
Rhizoma Dioscoreae 1770g Semen Armeniacae Amarum 440g Herba Pogostemonis 2650g
Flos Lonicerae 90g
Preparation method:
Put into decoction pot by through the Semen Phaseoli selecting and rinse, add water 442.5kg, is heated to boiling, then keeps slight boiling condition 2 hours at 98 DEG C-101 DEG C.By decocting liquid, filter 250 order stainless steel filtering nets, obtain Semen Phaseoli water, density is 1.04 (40 DEG C), pH=6.58.The another device of Semen Phaseoli slag is collected.
Semen Coicis, Semen Euryales, Rhizoma Dioscoreae, Semen Armeniacae Amarum are put into stainless steel cask, with the warm water 44kg of 40 DEG C, soak 2 hours, add Herba Pogostemonis and Flos Lonicerae again, soak after 1 hour, be dosed in decoction pot, the Semen Phaseoli slag upper step obtained adds, add water 88.5kg again, is heated to boiling, and then 98-101 DEG C keeps slight boiling condition 3 hours.Decoction liquor filtered, being concentrated into density is 1.18 (40 DEG C), and detecting pH is 5.88.The Semen Phaseoli water upper step obtained adds filtrate, stirs and makes to be uniformly dispersed, be then transferred in Agitation Tank, add 1770g (2 weight portion) white sugar, stir 30 minutes, and detect pH=6.27, density is: 1.04 (40 DEG C).Then filtered by the flame filter press of feed liquid by 0.8 μm, proceed to fluid reservoir, load can, every canned 310ml, sterilizing, obtains target liq beverage.
embodiment 10a kind of liquid beverage of invigorating the spleen to clear away damp pathogen
Crude drug forms:
Semen Coicis 4430g Semen Phaseoli 4430g Semen Euryales 2650g
Rhizoma Dioscoreae 1770g Semen Armeniacae Amarum 1330g Herba Pogostemonis 500g
Flos Lonicerae 440g
Preparation method:
Put into decoction pot by through the Semen Phaseoli selecting and rinse, add water 442.5kg, is heated to boiling, then keeps slight boiling condition 2.5 hours at 98 DEG C-101 DEG C.By decocting liquid, filter 250 order stainless steel filtering nets, obtain Semen Phaseoli water, density is 0.96 (40 DEG C), pH=6.77.The another device of Semen Phaseoli slag is collected.
Semen Coicis, Semen Euryales, Rhizoma Dioscoreae, Semen Armeniacae Amarum are put into stainless steel cask, add the warm water 44kg of 50 DEG C, soak 2 hours, add Herba Pogostemonis and Flos Lonicerae again, soak after 1 hour, be dosed in decoction pot, the Semen Phaseoli slag upper step obtained adds, add water 88.5kg again, is heated to boiling, and then 98-101 DEG C keeps slight boiling condition 2 hours.Decoction liquor filtered, being concentrated into density is 1.02 (40 DEG C), and detecting pH is 5.83.The Semen Phaseoli water upper step obtained adds filtrate, stirs and makes to be uniformly dispersed, be then transferred in Agitation Tank, stir 30 minutes, and detect pH=6.22, density is: 1.01 (40 DEG C).Then filtered by the flame filter press of feed liquid by 0.8 μm, proceed to fluid reservoir, load the two panels aluminium pot being filled with nitrogen, every canned 310ml, sterilizing, obtains target liq beverage.
embodiment 11a kind of liquid beverage of invigorating the spleen to clear away damp pathogen
Crude drug forms:
Semen Coicis 5kg Semen Phaseoli 5kg Semen Euryales 3kg
Rhizoma Dioscoreae 2kg Semen Armeniacae Amarum 1.5kg Herba Pogostemonis 0.6kg
Flos Lonicerae 0.5kg
Preparation method:
Put into decoction pot by through the Semen Phaseoli selecting and rinse, add water 500kg, is heated to boiling, then keeps slight boiling condition 2.5 hours at 98 DEG C-101 DEG C.By decocting liquid, filter 250 order stainless steel filtering nets, obtain Semen Phaseoli water, density is 0.94 (40 DEG C), pH=6.76.The another device of Semen Phaseoli slag is collected.
Semen Coicis, Semen Euryales, Rhizoma Dioscoreae, Semen Armeniacae Amarum are put into stainless steel cask, add the warm water 50kg of 50 DEG C, soak 2 hours, add Herba Pogostemonis and Flos Lonicerae again, soak after 1 hour, be dosed in decoction pot, the Semen Phaseoli slag upper step obtained adds, add water 100kg again, is heated to boiling, and then 98-101 DEG C keeps slight boiling condition 2 hours.Decoction liquor filtered, being concentrated into density is 1.02 (40 DEG C), and detecting pH is 5.84.The Semen Phaseoli water upper step obtained adds filtrate, stirs and makes to be uniformly dispersed, be then transferred in Agitation Tank, stir 30 minutes, and detect pH=6.22, density is: 1.01 (40 DEG C).Then filtered by the flame filter press of feed liquid by 0.8 μm, proceed to fluid reservoir, load the two panels aluminium pot being filled with nitrogen, every canned 310ml, sterilizing, obtains target liq beverage.
embodiment 12a kind of Chinese medicine granules of invigorating the spleen to clear away damp pathogen
Crude drug forms:
Semen Coicis 4kg Semen Phaseoli 1kg Semen Euryales 2.5kg
Rhizoma Dioscoreae 0.5kg Semen Armeniacae Amarum 0.5kg
Preparation method: put into decoction pot by through the above medical material selecting and rinse, the warm water 200kg adding 45 DEG C soaks 3 hours, is heated to boiling, then keeps slight boiling condition 2 hours at 98 DEG C-101 DEG C.Decocting liquid is filtered 250 order stainless steel filtering nets.Decoction liquor density is 1.013 (40 DEG C), pH=5.94.Through concentrated, drying under reduced pressure is dry extract, add dextrin (dry extract and dextrin weight ratio are 2:3) to mix, granulate with appropriate 85% ethanol (volumn concentration) moistening, wet grain drying, moisture Control is below 2%, granulate, subpackage, every bag of 5.5g, obtains target particles agent; Every 1g, containing dry extract 0.4g, is equivalent to crude drug amount 2.7g.
Consumption usage: once a day, each 1 bag.
test example 1acute toxicity testing
In order to the safety of pharmaceutical composition of the present invention is described, respectively according to raw material composition and the described preparation method of embodiment 1-10, prepare the Chinese medicine composition not comprising adjuvant, as being subject to test product.According to every mouse stomach 0.2ml/10g body weight, every rat oral gavage 2ml/100g body weight calculates, and is subject to test product, adds water and be mixed with debita spissitudo, for liquid by test product, suitably concentrate for solid-state; Make the gastric infusion dosage of mice be 103.0g crude drug/kg body weight, the gastric infusion dosage of rat is 77g crude drug/kg body weight.Result is as follows:
After administration, all Mouse and rats occur that light activity reduces, and 2 hours recover normal substantially, Continuous Observation 14 days after administration, there is no animal dead, its hair situation, diet amount of drinking water, activity, defecation and body weight growth are compared with normal group, equal no significant difference.Experimental result shows, when mouse stomach Chinese medicine composition 103.0g crude drug/kg/d of the present invention, rat oral gavage Chinese medicine composition of the present invention 77g crude drug/kg/d is safe.Chinese medicine composition clinical application every day total amount of the present invention is 0.43g crude drug/kg/d, and by tester, in this experiment, the gavage of large mice is more than 50 times of human body clinical application every day total amount, and show that this medicine acute toxicity is low, clinical application is safe.
test example 2animal Behavior Science is tested
This research is intended causing rat damp-heat syndrome by simulation Guangdong and Guangxi Provinces and the complex factors (outside hygrothermal environment, high glucose and high fat diet and pathogenic microorganism) such as Hainan Region mankind's external environment condition and dietary habit, observe the change of damp-heat syndrome rat behavior, inquire into damp eliminating Jianpi Decoction of the present invention to the intervention effect of its behavior.
1, test medicine
Invigorating the spleen to clear away damp pathogen soup: the liquid beverage prepared according to raw material composition and the preparation method of the embodiment of the present invention 10, be concentrated into 0.375g crude drug/ml (low dosage), 1.875g crude drug/ml (middle dosage) and 3.75g crude drug/ml (high dose).
2, divide into groups
SPF level Wistar rat 60, male and female half and half, weight 180 ~ 220g, 5 groups are divided at random by digital random table method, often organize 12, be respectively matched group, syndrome of dampness-heat of spleen and stomach group (damp and hot group) and test group (low dosage, middle dosage, high dose group, respectively referred to as dispel low group, dispel middle group, dispel high group).Damp and hot treated animal is fasting 12h before experiment, freely drinks water.
2, experimental technique
(1) matched group: 20-28 DEG C of temperature, under 50%-60% relative humidity conditions, feed with common mixed fodder, every day, 8:30 threw feedstuff.(2) damp and hot group: high glucose and high fat forage feed 10 days, wherein fix a point to be placed in for two hours in analogue simulation climate compartment the 1st day to the 8th day every day, temperature 33 degree (33 ± 2) DEG C in cabin, relative humidity (75 ± 5) %, within 9th day, 8:30 starts gavage, give escherichia coli 1 time by 2ml/200g body weight, press 1ml/200g body weight after 24 hours again and strengthen infection 1 time, then move to and be placed in natural environment out of my cabin.(3) test group three dosage groups: give damp and hot group of same process, but from the 4th day, to be placed in natural environment after 12 hours shifting out analogue simulation climate compartment, dispel low group, dispel middle group, high group respectively with the invigorating the spleen to clear away damp pathogen soup of basic, normal, high dosage, by 2ml/100g body weight gavage of dispelling, 1 times/day, totally 7 days.Observe the behavior of animal, symptom, sign record every day, the results are shown in Table 1, and carry out the experiment of spacious field the 3rd day and the 11st day respectively, record the center lattice time of staying of rat, motion lattice number, upright number of times respectively.Estimated by Open-field behavior, with toy behavioristics record analysis system (comprising camera system and signal processing system two parts), camera system is fixed on above the experimental box of spacious field and records a video, and observes the situation of change of animal.The results are shown in Table 2, table 3, table 4.
Table 1 medicine is on the impact of animal behavior, symptom, sign
As can be seen from Table 1, matched group Non Apparent Abnormality performance.Damp and hot group As time goes on, major part shows as asthenia, drowsiness lazyness is dynamic, bradykinesia, hair are fluffy, color is withered, diet reduces, defecation frequency increases, it is glutinous greasy to defecate, after gavaging escherichia coli, rat temperature obviously raises, simulate syndrome of dampness-heat of spleen and stomach.The each dosage group of damp eliminating, before gavaging invigorating the spleen to clear away damp pathogen soup, also shows the minimizing of movable diet, stool is glutinous greasy, and modeling success is described; Upon administration, the activity of each treated animal increases gradually, and dietary amount increases, and defecation recovers normal gradually, and temperature recovery is to normal level.Therefore, this test illustrates, the symptom of invigorating the spleen to clear away damp pathogen soup of the present invention to syndrome of dampness-heat of spleen and stomach rat model has improvement result significantly.
The change of the table 2 center lattice time of staying is compared
| Group | 3rd day number of animals | The 3rd day time of staying (min) | 11st day number of animals | The 11st day time of staying (min) |
| Matched group | 12 | 4.23±2.24 | 12 | 4.25±2.01 |
| Damp and hot group | 12 | 8.14±2.93 ** | 12 | 8.67±2.59 ** |
| Dispel low group | 12 | 8.09±2.64 **▲ | 12 | 5.21±1.96 △△ |
| Dispel middle group | 12 | 8.37±3.27 **▲ | 12 | 5.06±1.24 △△ |
| Dispel great-great-grandfather | 12 | 8.22±3.71 **▲ | 12 | 5.34±2.23 △△ |
*: compare with matched group, P < 0.01;
▲: compare with damp and hot group, P > 0.05;
△ △: compare with damp and hot group, P < 0.01.
As can be seen from Table 2, before treatment (the 3rd day), damp and hot group, test each dosage group and compare with matched group, the center lattice time of staying all increases; After treatment (the 11st day), test each dosage group all has decline in various degree compared with before treatment.
The change of table 3 motion lattice number is compared
| Group | 3rd day number of animals | 3rd day motion lattice number (lattice) | 11st day number of animals | 11st day motion lattice number (lattice) |
| Matched group | 12 | 43.40±8.24 | 12 | 46.25±8.01 |
| Damp and hot group | 12 | 32.14±7.93 ** | 12 | 31.67±7.59 ** |
| Dispel low group | 12 | 32.20±2.64 **▲ | 12 | 40.21±8.96 △△ |
| Dispel middle group | 12 | 33.37±9.27 **▲ | 12 | 42.06±8.24 △△ |
| Dispel great-great-grandfather | 12 | 33.22±8.71 **▲ | 12 | 39.34±7.23 △△ |
*: compare with matched group, P < 0.01;
▲: compare with damp and hot group, P > 0.05;
△ △: compare with damp and hot group, P < 0.01.
As can be seen from Table 3, before treatment (the 3rd day), damp and hot group, test each dosage group and compare with matched group, motion lattice number obviously reduces; After treatment (the 11st day), testing each dosage group motion lattice number compared with before treatment all has increase in various degree.
The table 4 respectively upright number of times of group compares
| Group | 3rd day number of animals | 3rd day upright number of times (secondary) | 11st day number of animals | 11st day upright number of times (secondary) |
| Matched group | 12 | 9.40±2.24 | 12 | 9.84±3.01 |
| Damp and hot group | 12 | 5.14±2.93 ** | 12 | 5.67±2.59 ** |
| Dispel low group | 12 | 5.20±2.64 **▲ | 12 | 9.21±2.96 △△ |
| Dispel middle group | 12 | 5.37±2.27 **▲ | 12 | 9.46±2.24 △△ |
| Dispel great-great-grandfather | 12 | 5.22±2.71** ▲ | 12 | 9.34±2.23 △△ |
*: compare with matched group, P < 0.01;
▲: compare with damp and hot group, P > 0.05;
△ △: compare with damp and hot group, P < 0.01.
As can be seen from Table 4, before treatment (the 3rd day), damp and hot group, test each dosage group and compare with matched group, upright number of times obviously reduces; After treatment (the 11st day), testing each dosage group upright number of times compared with before treatment all has increase in various degree.
Consolidated statement 2-table 4 can be found out, before treatment (the 3rd day), damp and hot group and each rats in test groups Spatial cognitive Abilities low, motion lattice number, upright number of times are obviously less than matched group, show that each group of rat irritability reduces, weaken the adaptive capacity of new environment, the autonomic activities in foreign environment and exploratory behavior reduce.Its center lattice time of staying, motion lattice number and damp and hot group of upright number of times and each test group no significant difference, but these four groups to be compared with matched group that there were significant differences (P<0.01), prove the damp and hot modeling success of modeling group.After treatment (the 11st day), rat behavior performance is all improved, and each test group and damp and hot group compare statistical significance (P<0.01).Illustrate that the Chinese medicine composition of invigorating the spleen to clear away damp pathogen of the present invention has and regulate the effect of rat behavior, this may with the damp eliminating of described Chinese medicine composition, spleen invigorating, heat clearing away effect and can to improve the effect of organismic internal environment relevant.
test example 3clinical efficacy
In order to verify the beneficial effect of technical solution of the present invention further, the product of embodiment 1-10 is adopted to do following research:
1, be chosen at In Guangdong Province to live more than 10 years, and have in mouth sticky, headache heavy sensation of the body, the subhealth state experimenter of the damp and hot symptom such as oliguria with reddish urine 550, wherein male 275, women 275, is divided into 11 groups at random according to the ratio of 1:1, wherein treatment group totally 10 groups, often organize 50 examples (treatment group 1-10), the Chinese medicine composition of oral embodiment 1-10, by consumption usage described in embodiment, is 15g crude drug amount for each person every day respectively.Matched group 50 example (sanren decoction group), the oral sanren decoction 200ml of matched group (amounting to into crude drug amount 15g), every day twice.Often organizing and all give health guidance, 15 days is a course for the treatment of, observes 3 courses for the treatment of altogether.
The preparation of sanren decoction: each 2.5 weight portions of Semen Armeniacae Amarum, the Rhizoma Pinelliae, flies Talcum, each 3 weight portions of Semen Coicis, white Medulla Tetrapanacis, Fructus Amomi Rotundus, Folium Bambusae, each 1 weight portion of Cortex Magnoliae Officinalis.Add 300 weight parts waters to decoct, keep micro-and boil 2-3 hour, filter, filtrate is condensed into the extract of 200 weight portions.
2, diagnostic criteria
The table 5 damp-heat constitution subhealth symptom table of integrals (being as the criterion with long-term self-condition)
| Cardinal symptom | Nothing | Have once in a while | Often have | Continue to have |
| Sticky in mouthful | 0 | 2 | 4 | 6 |
| Bitter taste halitosis | 0 | 2 | 4 | 6 |
| Loose stool is not well | 0 | 2 | 4 | 6 |
| Urine yellow skin | 0 | 2 | 4 | 6 |
| The tired power of body | 0 | 2 | 4 | 6 |
| Red tongue with yellow fur | 0 | 2 | 4 | 6 |
| Nausea and vomiting | 0 | 2 | 4 | 6 |
| Not for drink | 0 | 2 | 4 | 6 |
| Abdominal distention | 0 | 2 | 4 | 6 |
Curative effect index: damp-heat constitution subhealth symptom, adopting from intending the damp-heat constitution subhealth symptom table of integrals, observing Self-variation before and after treatment and comparing between self and group.
Safety index: observe serum TG, TC, urine, stool routine examination, liver function, kidney merit.
Curative effect judging standard:
Adopt nimodipine method, integration before and after treatment substituted into symptom total mark rate of descent before and after the treatment of following formulae discovery:
Total mark rate of descent=[before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%;
According to total mark rate of descent, set up curative effect judging standard:
Effective: original symptom and sign major part disappears or obviously alleviates, total mark rate of descent >70%;
Effective: original symptom and sign alleviates before comparatively treating, 30% < total mark rate of descent≤70%;
Invalid: original symptom and sign without improvement, total mark rate of descent≤30%.
3, result
The clinical observation on the therapeutic effect result of each group, in table 6.Serum TG, TC in each group of group, urine, stool routine examination, liver function, kidney merit, do not have significant change before treatment and after treatment.
Table 6 clinical observation result
| Group | Number of cases | Effective (example, %) | Effectively (example, %) | Invalid (example, %) | Total effective rate (example, %) |
| Treatment group 1 | 50 | 28(56％) | 21(42％) | 1(2％) | 49(98％) |
| Treatment group 2 | 50 | 29(58％) | 20(40％) | 1(2％) | 49(98％) |
| Treatment group 3 | 50 | 25(50％) | 23(46％) | 2(4％) | 48(96％) |
| Treatment group 4 | 50 | 31(62％) | 19(38％) | 0(0％) | 50(100％) |
| Treatment group 5 | 50 | 26(52％) | 22(44％) | 2(4％) | 48(96％) |
| Treatment group 6 | 50 | 32(64％) | 18(36％) | 0(0％) | 50(100％) |
| Treatment group 7 | 50 | 31(62％) | 19(38％) | 0(0％) | 50(100％) |
| Treatment group 8 | 50 | 33(66％) | 17(34％) | 0(0％) | 50(100％) |
| Treatment group 9 | 50 | 34(68％) | 16(32％) | 0(0％) | 50(100％) |
| Treatment group 10 | 50 | 38(76％) | 12(24％) | 0(0％) | 50(100％) |
| Matched group | 50 | 24(48％) | 19(38％) | 7(14％) | 43(86％) |
As seen from the above table, compare sanren decoction, the improvement effect of Chinese medicine composition to Guangdong and Guangxi Provinces locals's damp-heat constitution with invigorating the spleen to clear away damp pathogen effect provided by the invention is more obvious, and the average effectiveness level of 3 courses for the treatment of of 10 treatment groups is 98.8%, and matched group effective percentage is only 86%.Wherein, the treatment group effective percentage of the product of oral embodiment 4, embodiment 6-10 is 100%, especially best with the effect of the treatment group of oral embodiment 10 product.
Claims (10)
1. a Chinese medicine composition for invigorating the spleen to clear away damp pathogen, is characterized in that, the crude drug of described Chinese medicine composition comprises: Semen Coicis 2-8 weight portion, Semen Phaseoli 2-8 weight portion, Semen Euryales 1-5 weight portion, Rhizoma Dioscoreae 1-5 weight portion, Semen Armeniacae Amarum 0.5-3 weight portion;
Preferably, the crude drug of described Chinese medicine composition comprises: Semen Coicis 3-7 weight portion, Semen Phaseoli 3-7 weight portion, Semen Euryales 2-4 weight portion, Rhizoma Dioscoreae 1-3 weight portion, Semen Armeniacae Amarum 1-2 weight portion.
2. Chinese medicine composition according to claim 1, is characterized in that, the crude drug of described compositions comprises: Semen Coicis 4-6 weight portion, Semen Phaseoli 4-6 weight portion, Semen Euryales 2.5-3.5 weight portion, Rhizoma Dioscoreae 1.5-2.5 weight portion, Semen Armeniacae Amarum 1.3-1.7 weight portion.
3. Chinese medicine composition according to claim 1 and 2, is characterized in that, the crude drug of described Chinese medicine composition also comprises: Herba Pogostemonis 0.1-3 weight portion, Flos Lonicerae 0.1-3 weight portion;
Preferably, the crude drug of described Chinese medicine composition also comprises: Herba Pogostemonis 0.5-1.5 part, Flos Lonicerae 0.5-1.5 part;
Preferred, the crude drug of described Chinese medicine composition also comprises: Herba Pogostemonis 0.5-0.8 weight portion, Flos Lonicerae 0.4-0.6 weight portion.
4. a Chinese medicine composition for invigorating the spleen to clear away damp pathogen, is characterized in that, consisting of of the crude drug of described Chinese medicine composition:
Semen Coicis 4430 grams, Semen Phaseoli 4430 grams, Semen Euryales 2650 grams, Rhizoma Dioscoreae 1770 grams, Semen Armeniacae Amarum 1330 grams, Herba Pogostemonis 500 grams, Flos Lonicerae 440 grams.
5. Chinese medicine composition according to any one of claim 1 to 4, is characterized in that, described Chinese medicine composition also comprises pharmaceutically acceptable adjuvant, makes acceptable oral formulations clinically;
Preferably, described oral formulations is selected from capsule, tablet, granule, oral solution or oral liquid; Preferred, described oral formulations is oral solution.
6. the preparation method of the Chinese medicine composition according to any one of claim 1 to 5, is characterized in that, comprises the steps:
Each crude drug is taken by formula, mixing, rinses crude drug with water, and 40-50 DEG C of water 400-500 weight portion soaks 2-3 hour, be heated to boiling, then keep slight boiling condition 2-3 hour, filter, preferably filter with 100-250 order stainless steel filtering net, filtrate concentrates, drying, adds pharmaceutically acceptable adjuvant, makes oral formulations.
7. the preparation method of the Chinese medicine composition according to any one of claim 1 to 5, is characterized in that, described Chinese medicine composition is oral solution, and described preparation method comprises the steps:
1) each crude drug is taken by formula;
2) the 400-500 weight portion that first added water by Semen Phaseoli decocts, and keeps micro-and boils 2-3 hour, filter, preferably filter with 100-250 order stainless steel filtering net, obtain Semen Phaseoli filtrate and Semen Phaseoli slag after water boils, for subsequent use respectively;
3) each for all the other except Semen Phaseoli crude drug 40-50 DEG C of water 40-60 weight portion is soaked 2-3 hour, then add the Semen Phaseoli slag that step 2 obtains, then the 80-120 weight portion that adds water is heated to boiling, then slight boiling condition 2-3 hour is kept, filter, filtrate adds the Semen Phaseoli water that step 2 obtains, and stirs, make to be uniformly dispersed, stir, filter, filter preferably by the flame filter press of 0.8 μm, sterilizing, obtains described Chinese medicine composition;
Preferably, in described step 3, after described filtrate adds described Semen Phaseoli water, before filtration, correctives can be added; Preferably add stevioside or white sugar, more preferably add 2-20 weight portion white sugar.
8. the Chinese medicine composition prepared by preparation method described in claim 6 or 7.
9. a liquid beverage, is prepared by preparation method according to claim 7.
10. the Chinese medicine composition according to any one of claim 1 to 5, Chinese medicine composition according to claim 8 or liquid beverage according to claim 9 are preparing the purposes had in the medicine of invigorating the spleen to clear away damp pathogen effect.
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