CN105944087A - Micro-leaven saffron decoction pieces capable of clearing heat and dissipating phlegm and preparation method thereof - Google Patents

Micro-leaven saffron decoction pieces capable of clearing heat and dissipating phlegm and preparation method thereof Download PDF

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CN105944087A
CN105944087A CN201610412751.3A CN201610412751A CN105944087A CN 105944087 A CN105944087 A CN 105944087A CN 201610412751 A CN201610412751 A CN 201610412751A CN 105944087 A CN105944087 A CN 105944087A
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parts
decoction pieces
saffron
phlegm
micro
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袁学才
宁长红
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Anhui Yuanhetang Pharmaceutical Co Ltd
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Anhui Yuanhetang Pharmaceutical Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/01Hydrolysed proteins; Derivatives thereof
    • A61K38/011Hydrolysed proteins; Derivatives thereof from plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/58Reptiles
    • A61K35/586Turtles; Tortoises, e.g. terrapins
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/01Hydrolysed proteins; Derivatives thereof
    • A61K38/012Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/014Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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Abstract

The invention discloses micro-leaven saffron decoction pieces capable of clearing heat and dissipating phlegm and a preparation method thereof. The saffron decoction pieces are prepared from, by weight, 50-60 parts of saffron, 30-35 parts of collagen powder, 13-15 parts of colla carapacis et plastri testudinis, 130-150 parts of rice bran protein powder, 15-18 parts of bitter apricot seeds, 15-18 parts of red phaseolus beans, 13-15 parts of oysters, 10-12 parts of semen perillae acutae, 30-35 parts of honey, 50-55 parts of wine-prepared dark plum fruit and 10-12 parts of periostracum cicada. According to the micro-leaven saffron decoction pieces capable of clearing the heat and dissipating the phlegm, the collagen powder and the rice bran protein powder replace traditional flour to serve as powder for preparing the pieces, nutrition is richer, the taste is more refreshing, the decoction pieces are easier to digest and absorb, and effective ingredients contained in the decoction pieces have the health-care effects of cleaning the heat, dissipating the phlegm, tonifying the spleen, enhancing resistance and the like.

Description

A kind of Removing heat-phlegm micro-ferment Stigma Croci decoction pieces And preparation method thereof
Technical field
The present invention relates to prepared slices of Chinese crude drugs technical field, particularly relate to a kind of removing heat-phlegm micro-ferment Stigma Croci decoction pieces and preparation method thereof.
Background technology
The prepared slices of Chinese crude drugs are under guidance of traditional Chinese medicine theory, and according to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle and the needs of formulation dispensing, the finished product that centering processing of crude drugs is concocted is tcm clinical practice medication, play dialectical plus-minus, embody the basis of personalized medicine principle.The prepared slices of Chinese crude drugs are one of big pillars of Chinese herbal medicine industry three , the important component part of Ye Shi China traditional medicine, diseases prevention, cure the disease in play an important role.Therefore the quality of The Quality of Sliced Herbal Medicine will directly influence the effect of tcm clinical practice treatment, have influence on people's life's health and the safety of medication.
Chinese medicine wall cell disruption powder body and Chinese medicine wall cell disruption decoction pieces are the modern developments of Chinese medicinal powder application, and the more traditional decoction pieces of utilization rate of its material base has a more substantial increase.Research work expands around association area and studies more than the tackling key problem of 300 sub-problems.The Chinese crude drug overwhelming majority derives from natural plant, derives from animal, mineral and artifact on a small quantity.And plant medicine material is respectively provided with cell wall structure, using traditional decoction extracting mode, cell wall can stop the dissolution of intracellular active substance to a great extent, causes active ingredients from traditional Chinese medicinal utilization rate low, serious waste of resources.Chinese medicine wall cell disruption decoction pieces breaks cell wall by modern crushing technology, the material in cell wall is allowed to be prone to dissolution and mix homogeneously, the problem that can be effectively improved the material base inhomogeneities that Chinese crude drug causes because its position and tissue etc. are different, improve leaching rate and the utilization rate of effective ingredient in medical material, also achieve Chinese medicine without long-time high temperature decoct extract process, and apply convenient.And in traditional Chinese herbs broken wall link, rational breaking cell wall diameter of particle is that it is crucial.The diameter of general cell is all about 10-100 μm.After being processed by cellular level pulverizing, traditional Chinese medicine powder being broken to 300 mesh (sieve aperture internal diameter is 47 μm), cell-wall breaking ratio can reach 86.5%.The 300 above Chinese traditional powder of mesh, 98% micropowder can only see cell debris.The medium particle diameter that general 300 mesh Chinese medicinal powder microscope inspections measure is 4-10 μm.The ultrafine Chinese herb of this particle diameter can make its components utilising rate improve to 60-90%.From economic and technical comprehensive examination and evaluation, Chinese medicine wall cell disruption decoction pieces selects micronizing to be machined to D90 < 45 μm, and < powder body of 45 μm (more than 300 mesh) is as the standard of Chinese medicine wall cell disruption powder body for the diameter of particle of i.e. more than 90%.This breaking cell wall processes and belongs to fine physical refining process, and intracellular material composition does not causes the change of matter.The wall breaking pulverization technology of Chinese medicine is existing in the industry the most mature has two classes: one has rigid solid medium to participate in, by clashing into, shear, the conventional size reduction principle such as friction break the technology of cell wall;Two do not have rigid solid medium to participate in, and utilize strong air flow allow Chinese traditional powder self high frequency , fast ram and break the technology of cell wall.The feature of crushing technology that rigid solid medium participates in is: medium, owing to being clashed into and rubbing, easy to wear comes off, pollution medical material;When medium high-speed impact, shearing medical material, make medical material produce higher temperature, be unfavorable for the protection of heat-sensitive ingredients;But the subject range width that this technology is to medical material, requires low to the physical property of material.The feature of airflow pulverization is: do not have rigid solid medium contacting material, and the heat absorption of air-flow high speed pay-out and the heat production of material impacting are offset, and material does not heats up at crushing process, so that heat-sensitive ingredients is effectively protected;But the physical property of material is required higher by airflow pulverization, and subject range is narrower.For ensureing that the Chinese traditional powder processed through cell wall breaking is pollution-free to greatest extent, not heating up, Chinese medicine wall cell disruption decoction pieces selects airflow pulverization to realize breaking cell wall.Chinese medicine wall cell disruption decoction pieces, after wall breaking pulverization processes, defines the specific surface area moisture absorption big, easy, the oxidizable and powder body of poor fluidity, extremely unstable and be difficult to the requirement meeting industrialized production to its mobility.Therefore, molding is to reduce specific surface area again after breaking cellular wall to allow Chinese medicine wall cell disruption powder body, and improving stability is exactly the key problem in technology of its industrialization.
Summary of the invention
The object of the invention is contemplated to make up the defect of prior art, it is provided that a kind of removing heat-phlegm micro-ferment Stigma Croci decoction pieces.
The present invention is achieved by the following technical solutions:
A kind of removing heat-phlegm micro-ferment Stigma Croci decoction pieces, is made up of following raw materials in part by weight:
Stigma Croci 50-60, collagen protein powder 30-35, Colla Plastri Testudinis 13-15, rice bran protein powder 130-150, Semen Armeniacae Amarum 15-18, Semen Phaseoli 15-18, Concha Ostreae 13-15, Fructus Perillae 10-12, Mel 30-35, processed with wine Fructus Mume 50-55, Periostracum Cicadae 10-12.
Described a kind of removing heat-phlegm micro-ferment Stigma Croci decoction pieces, is made up of the following step:
1), Colla Plastri Testudinis, Concha Ostreae, Fructus Perillae, processed with wine Fructus Mume, Periostracum Cicadae being added in steamer, decoct altogether twice, the decoction liquor after filter is taken out, and loads in clean container;
2), by Stigma Croci, Semen Armeniacae Amarum, Semen Phaseoli mix homogeneously in rustless steel container, and put into pulverizer, cross 100-120 mesh sieve after being ground into fine powder, recycle airflow pulverization, it is carried out fining-off so that it is reach 300-350 mesh;
3), adding in mixer by step 2 gained mixture with Mel, collagen protein powder, rice bran protein powder, after being sufficiently mixed, the mixing decoction liquor adding step 1 gained is stirred soft material processed, stirs 15-20 minute;
4) pile up in heaps in, stainless steel disc being put in the taking-up of step 3 gains, surface is patted smooth, cover tightly with non-woven fabrics, it is 30-35 DEG C, humidity 70-80% in temperature, ferments, after 3-4 days, treat that white mould clothing is uniformly born on stockpile surface, and crackle occurs, break section into two with one's hands when having cellular, fermented standby;
5) mixture, by step 4 fermented is whole broken, puts in molding device, operates by molding device standard operating procedure, is cut into the cubed pieces of the long 1.0-1.5cm of rib;
6), by step 5 gained cubed pieces, load in a clean rustless steel drip pan, pave, must not extrude, put in heated-air circulation oven and dry, operate according to heated-air circulation oven standard operating procedure, baking temperature is 70-80 DEG C, and drying time is 4-5 hour, and water content control is at 7-12%, after drying, take out, cool, loading in clean container, use outer, the form of interior two layers of composite packaging, internal layer packaging is non-toxic polyethylene bag, outer packaging is corrugated case, kept dry.
The invention have the advantage that
1, a kind of removing heat-phlegm micro-ferment Stigma Croci decoction pieces of the present invention; by airflow pulverization, material is pulverized; there is no rigid solid medium contacting material; the heat absorption of air-flow high speed pay-out and the heat production of material impacting are offset; material does not heats up at crushing process, so that heat-sensitive ingredients is effectively protected.
2, a kind of removing heat-phlegm micro-ferment Stigma Croci decoction pieces of the present invention, replace conventional flours as film-making powder by collagen protein powder, rice bran protein powder, make nutrition abundanter, mouthfeel is salubriouser, be more easy to digest and assimilate, contained effective ingredient have heat clearing away, reduce phlegm, spleen invigorating, the health-care effect such as build up resistance.
Detailed description of the invention
A kind of removing heat-phlegm micro-ferment Stigma Croci decoction pieces, is made up of following raw materials in part by weight:
Stigma Croci 50, collagen protein powder 30, Colla Plastri Testudinis 13, rice bran protein powder 130, Semen Armeniacae Amarum 15, Semen Phaseoli 15, Concha Ostreae 13, Fructus Perillae 10, Mel 30, processed with wine Fructus Mume 50, Periostracum Cicadae 10.
Described a kind of removing heat-phlegm micro-ferment Stigma Croci decoction pieces, is made up of the following step:
1), Colla Plastri Testudinis, Concha Ostreae, Fructus Perillae, processed with wine Fructus Mume, Periostracum Cicadae being added in steamer, decoct altogether twice, the decoction liquor after filter is taken out, and loads in clean container;
2), by Stigma Croci, Semen Armeniacae Amarum, Semen Phaseoli mix homogeneously in rustless steel container, and put into pulverizer, cross 100 mesh sieves after being ground into fine powder, recycle airflow pulverization, it is carried out fining-off so that it is reach 320 mesh;
3), adding in mixer by step 2 gained mixture with Mel, collagen protein powder, rice bran protein powder, after being sufficiently mixed, the mixing decoction liquor adding step 1 gained is stirred soft material processed, stirs 15 minutes;
4), by step 3 gains take out put stainless steel disc in pile up in heaps, surface pat smooth, cover tightly with non-woven fabrics, be 30 DEG C, humidity 70% in temperature, ferment, after 3 days, treat that white mould clothing is uniformly born on stockpile surface, and crackle occurs, break section into two with one's hands when having cellular, fermented standby;
5) mixture, by step 4 fermented is whole broken, puts in molding device, operates by molding device standard operating procedure, is cut into the cubed pieces of the long 1.0cm of rib;
6), by step 5 gained cubed pieces, load in a clean rustless steel drip pan, pave, must not extrude, put in heated-air circulation oven and dry, operate according to heated-air circulation oven standard operating procedure, baking temperature is 70 DEG C, and drying time is 4 hours, and water content control is 7%, after drying, take out, cool, loading in clean container, use outer, the form of interior two layers of composite packaging, internal layer packaging is non-toxic polyethylene bag, outer packaging is corrugated case, kept dry.

Claims (2)

1. removing heat-phlegm micro-ferment Stigma Croci decoction pieces, it is characterised in that be made up of following raw materials in part by weight:
Stigma Croci 50-60, collagen protein powder 30-35, Colla Plastri Testudinis 13-15, rice bran protein powder 130-150, Semen Armeniacae Amarum 15-18, Semen Phaseoli 15-18, Concha Ostreae 13-15, Fructus Perillae 10-12, Mel 30-35, processed with wine Fructus Mume 50-55, Periostracum Cicadae 10-12.
A kind of removing heat-phlegm micro-ferment Stigma Croci decoction pieces the most according to claim 1, it is characterised in that be made up of the following step:
1), Colla Plastri Testudinis, Concha Ostreae, Fructus Perillae, processed with wine Fructus Mume, Periostracum Cicadae being added in steamer, decoct altogether twice, the decoction liquor after filter is taken out, and loads in clean container;
2), by Stigma Croci, Semen Armeniacae Amarum, Semen Phaseoli mix homogeneously in rustless steel container, and put into pulverizer, cross 100-120 mesh sieve after being ground into fine powder, recycle airflow pulverization, it is carried out fining-off so that it is reach 300-350 mesh;
3), adding in mixer by step 2 gained mixture with Mel, collagen protein powder, rice bran protein powder, after being sufficiently mixed, the mixing decoction liquor adding step 1 gained is stirred soft material processed, stirs 15-20 minute;
4) pile up in heaps in, stainless steel disc being put in the taking-up of step 3 gains, surface is patted smooth, cover tightly with non-woven fabrics, it is 30-35 DEG C, humidity 70-80% in temperature, ferments, after 3-4 days, treat that white mould clothing is uniformly born on stockpile surface, and crackle occurs, break section into two with one's hands when having cellular, fermented standby;
5) mixture, by step 4 fermented is whole broken, puts in molding device, operates by molding device standard operating procedure, is cut into the cubed pieces of the long 1.0-1.5cm of rib;
6), by step 5 gained cubed pieces, load in a clean rustless steel drip pan, pave, must not extrude, put in heated-air circulation oven and dry, operate according to heated-air circulation oven standard operating procedure, baking temperature is 70-80 DEG C, and drying time is 4-5 hour, and water content control is at 7-12%, after drying, take out, cool, loading in clean container, use outer, the form of interior two layers of composite packaging, internal layer packaging is non-toxic polyethylene bag, outer packaging is corrugated case, kept dry.
CN201610412751.3A 2016-06-14 2016-06-14 Micro-leaven saffron decoction pieces capable of clearing heat and dissipating phlegm and preparation method thereof Pending CN105944087A (en)

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CN1370596A (en) * 2001-02-27 2002-09-25 吴戌 Mass dissipating and swelling eliminating health beverage
CN102961572A (en) * 2012-12-05 2013-03-13 江苏老蚕坊蚕桑生物科技开发有限公司 Pills for treating bronchitis
CN103690852A (en) * 2013-12-24 2014-04-02 王守华 Medicine for treating phthisis and preparation method of medicine
CN104001031A (en) * 2014-06-06 2014-08-27 湖州康企药业有限公司 Medicament for treating asthma
CN104324103A (en) * 2014-10-17 2015-02-04 磐安县道地磐药中药研究所 Medicated leaven pure powder superfine decoction piece and preparation method thereof
CN104524110A (en) * 2014-12-30 2015-04-22 深圳太太药业有限公司 Traditional Chinese medicine composition with functions of tonifying spleen and clearing damp

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