CN106075409A - A kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces and preparation method thereof - Google Patents
A kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces and preparation method thereof Download PDFInfo
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- CN106075409A CN106075409A CN201610642868.0A CN201610642868A CN106075409A CN 106075409 A CN106075409 A CN 106075409A CN 201610642868 A CN201610642868 A CN 201610642868A CN 106075409 A CN106075409 A CN 106075409A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces and preparation method thereof, be made up of following raw materials in part by weight: Fructus Momordicae 50 60, collagen protein powder 30 35, chitin 3 3.5, caramel 15 18, Semen Armeniacae Amarum 15 18, Semen Phaseoli 15 18, Rhizoma Coptidis 10 12, Aloe glue 10 12, mentha leave 10 12, rice vinegar 30 35, candied Bulbus Lilii 20 23, Rhizoma Dioscoreae powder 100 120.A kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces of the present invention, contained effective ingredient has the health-care effects such as antiinflammatory heat clearing away, removing heat from the lung and relieving sorethroat, preventing phlegm from forming and stopping coughing, loosening bowel to relieve constipation.
Description
Technical field
The present invention relates to prepared slices of Chinese crude drugs technical field, particularly relate to a kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces and
Preparation method.
Background technology
The prepared slices of Chinese crude drugs are under guidance of traditional Chinese medicine theory, according to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle and the needs of formulation dispensing, to Chinese medicine
The finished product of material Processing methods is tcm clinical practice medication, play dialectical plus-minus, embody the basis of personalized medicine principle.Chinese medicine is drunk
Sheet is one of big pillar of Chinese herbal medicine industry three, the important component part of Ye Shi China traditional medicine, diseases prevention, cure the disease in play
Important effect.Therefore the quality of The Quality of Sliced Herbal Medicine is by directly influencing the effect of tcm clinical practice treatment, has influence on the people
Masses' life and health and the safety of medication.
Chinese medicine wall cell disruption powder body and Chinese medicine wall cell disruption decoction pieces are the modern developments of Chinese medicinal powder application, the utilization rate of its material base
More traditional decoction pieces has a more substantial increase.Research work expands around association area and studies more than the tackling key problem of 300 sub-problems.
The Chinese crude drug overwhelming majority derives from natural plant, derives from animal, mineral and artifact on a small quantity.And plant medicine material
Being respectively provided with cell wall structure, use traditional decoction extracting mode, cell wall can stop intracellular active substance to a great extent
Dissolution, causes active ingredients from traditional Chinese medicinal utilization rate low, serious waste of resources.Chinese medicine wall cell disruption decoction pieces is broken by modern crushing technology
Cell wall, allows the material in cell wall be prone to dissolution and mix homogeneously, can be effectively improved Chinese crude drug because of its position and tissue etc. no
The problem of the material base inhomogeneities caused together, improves leaching rate and the utilization rate of effective ingredient in medical material, also achieves
Chinese medicine without long-time high temperature decoct extract process, and apply convenient.And in traditional Chinese herbs broken wall link, rational breaking cell wall
Diameter of particle is that it is crucial.The diameter of general cell is all about 10-100 μm.After being processed by cellular level pulverizing, in inciting somebody to action
Pulverizing medicinal materials is to 300 mesh (sieve aperture internal diameter is 47 μm), and cell-wall breaking ratio can reach 86.5%.The 300 above Chinese traditional powder of mesh, 98% is micro-
Powder can only see cell debris.The medium particle diameter that general 300 mesh Chinese medicinal powder microscope inspections measure is 4-10 μm.This grain
The ultrafine Chinese herb in footpath can make its components utilising rate improve to 60-90%.From economic and technical comprehensive examination and evaluation, Chinese medicine wall cell disruption decoction pieces selects
Selecting micronizing and be machined to D90 < 45 μm, < powder body of 45 μm (more than 300 mesh) breaks the diameter of particle of i.e. more than 90% as Chinese medicine
The standard of wall powder body.This breaking cell wall processes and belongs to fine physical refining process, intracellular material composition is not caused matter
Change.The wall breaking pulverization technology of Chinese medicine is the most mature in the industry two classes: one has rigid solid medium to participate in, by hitting
Hit, shear, the conventional size reduction principle such as friction breaks the technology of cell wall；Two do not have rigid solid medium to participate in, and utilize strong
Strong air-flow breaks the technology of cell wall by Chinese traditional powder self high frequency, fast ram.The pulverizing skill that rigid solid medium participates in
The feature of art is: medium, owing to being clashed into and rubbing, easy to wear comes off, and pollutes medical material；When medium high-speed impact, shearing medical material
, make medical material produce higher temperature, be unfavorable for the protection of heat-sensitive ingredients；But the subject range width that this technology is to medical material, to material
Physical property requires low.The feature of airflow pulverization is: do not have rigid solid medium contacting material, the suction of air-flow high speed pay-out
The heat production of heat and material impacting is offset, and material does not heats up at crushing process, so that heat-sensitive ingredients is effectively protected；But air-flow
The physical property of material is required higher by crushing technology, and subject range is narrower.For ensureing to greatest extent to process through cell wall breaking
Chinese traditional powder pollution-free, do not heat up, Chinese medicine wall cell disruption decoction pieces select airflow pulverization realize breaking cell wall.Chinese medicine wall cell disruption decoction pieces
After wall breaking pulverization processes, define the specific surface area moisture absorption big, easy, oxidizable and the powder body of poor fluidity, extremely unstable and difficulty
To meet the industrialized production requirement to its mobility.Therefore, allow Chinese medicine wall cell disruption powder body after breaking cellular wall again molding with reduce ratio
Surface area, improves the key problem in technology that stability is exactly its industrialization.
Summary of the invention
The object of the invention is contemplated to make up the defect of prior art, it is provided that a kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae drink
Sheet.
The present invention is achieved by the following technical solutions:
A kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces, is made up of following raw materials in part by weight:
Fructus Momordicae 50-60, collagen protein powder 30-35, chitin 3-3.5, caramel 15-18, Semen Armeniacae Amarum 15-18, Semen Phaseoli 15-
18, Rhizoma Coptidis 10-12, Aloe glue 10-12, mentha leave 10-12, rice vinegar 30-35, candied Bulbus Lilii 20-23, Rhizoma Dioscoreae powder 100-120.
Described a kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces, is made up of the following step:
1), Rhizoma Coptidis, Aloe glue, mentha leave, candied Bulbus Lilii, rice vinegar being added in steamer, decoct altogether twice, the decoction liquor after filter takes
Go out, load in clean container；
2), by Fructus Momordicae, Semen Armeniacae Amarum, Semen Phaseoli mix homogeneously in rustless steel container, and put into pulverizer, be ground into thin
Cross 100-120 mesh sieve after powder, recycle airflow pulverization, it is carried out fining-off so that it is reach 300-350 mesh；
3), step 2 gained mixture is added in mixer with caramel, collagen protein, Rhizoma Dioscoreae powder, after being sufficiently mixed, add
The mixing decoction liquor of step 1 gained is stirred soft material processed, stirs 15-20 minute；
4), by step 3 gains take out put stainless steel disc in pile up in heaps, surface pat smooth, cover tightly with non-woven fabrics, in temperature
For 30-35 DEG C, humidity 70-80%, ferment, after 3-4 days, treat that white mould clothing is uniformly born on stockpile surface, and crackle occurs, break
Cut-off mask when having cellular, fermented standby；
5) mixture, by step 4 fermented is whole broken, adds chitin mix homogeneously, puts in molding device, by molding device mark
Quasi-rule of operation operates, and is cut into the cubed pieces of the long 1.0-1.5cm of rib；
6), by step 5 gained cubed pieces, load in a clean rustless steel drip pan, pave, must not extrude, put into hot air circulation
Drying in baking oven, operate according to heated-air circulation oven standard operating procedure, baking temperature is 70-80 DEG C, when being dried
Between be 4-5 hour, water content control is at 7-12%, after drying, takes out, cools, loads in clean container, use outer, interior two layers multiple
Closing the form of packaging, internal layer packaging is non-toxic polyethylene bag, and outer packaging is corrugated case, kept dry.
The invention have the advantage that
1, a kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces of the present invention, is pulverized material by airflow pulverization,
Not having rigid solid medium contacting material, the heat absorption of air-flow high speed pay-out and the heat production of material impacting are offset, and material was being pulverized
Journey does not heats up, so that heat-sensitive ingredients is effectively protected.
2, the Chinese medicines such as Rhizoma Coptidis, Aloe glue, mentha leave, candied Bulbus Lilii are fully extracted by the present invention, lixiviating solution again with sieve
Fruit combines the Chinese, its heat clearing away prominent, the effect reduced phlegm.
3, a kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces of the present invention, contained effective ingredient has antiinflammatory heat clearing away, clear
The health-care effects such as lung sore-throat relieving, preventing phlegm from forming and stopping coughing, loosening bowel to relieve constipation.
Detailed description of the invention
A kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces, is made up of following raw materials in part by weight:
Fructus Momordicae 50, collagen protein powder 30, chitin 3, caramel 15, Semen Armeniacae Amarum 15, Semen Phaseoli 15, Rhizoma Coptidis 10, Aloe glue 10, thin
Folium Nelumbinis 10, rice vinegar 30, candied Bulbus Lilii 20, Rhizoma Dioscoreae powder 100.
Described a kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces, is made up of the following step:
1), Rhizoma Coptidis, Aloe glue, mentha leave, candied Bulbus Lilii, rice vinegar being added in steamer, decoct altogether twice, the decoction liquor after filter takes
Go out, load in clean container；
2), by Fructus Momordicae, Semen Armeniacae Amarum, Semen Phaseoli mix homogeneously in rustless steel container, and put into pulverizer, be ground into thin
Cross 100 mesh sieves after powder, recycle airflow pulverization, it is carried out fining-off so that it is reach 320 mesh；
3), step 2 gained mixture is added in mixer with caramel, collagen protein, Rhizoma Dioscoreae powder, after being sufficiently mixed, add
The mixing decoction liquor of step 1 gained is stirred soft material processed, stirs 15 minutes；
4), by step 3 gains take out put stainless steel disc in pile up in heaps, surface pat smooth, cover tightly with non-woven fabrics, in temperature
It is 30 DEG C, humidity 70%, ferments, after 3 days, treat that white mould clothing is uniformly born on stockpile surface, and crackle occurs, break section tool into two with one's hands
When having cellular, ferment standby；
5) mixture, by step 4 fermented is whole broken, adds chitin mix homogeneously, puts in molding device, by molding device mark
Quasi-rule of operation operates, and is cut into the cubed pieces of the long 1.0cm of rib；
6), by step 5 gained cubed pieces, load in a clean rustless steel drip pan, pave, must not extrude, put into hot air circulation
Drying in baking oven, operate according to heated-air circulation oven standard operating procedure, baking temperature is 70 DEG C, and drying time is
4 hours, water content control was 7%, after drying, takes out, cools, and loaded in clean container, used outer, interior two layers of composite packaging
Form, internal layer packaging is non-toxic polyethylene bag, and outer packaging is corrugated case, kept dry.
Claims (2)
1. antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces, it is characterised in that be made up of following raw materials in part by weight:
Fructus Momordicae 50-60, collagen protein powder 30-35, chitin 3-3.5, caramel 15-18, Semen Armeniacae Amarum 15-18, Semen Phaseoli 15-
18, Rhizoma Coptidis 10-12, Aloe glue 10-12, mentha leave 10-12, rice vinegar 30-35, candied Bulbus Lilii 20-23, Rhizoma Dioscoreae powder 100-120.
A kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces the most according to claim 1, it is characterised in that be by following step
Suddenly make:
1), Rhizoma Coptidis, Aloe glue, mentha leave, candied Bulbus Lilii, rice vinegar being added in steamer, decoct altogether twice, the decoction liquor after filter takes
Go out, load in clean container；
2), by Fructus Momordicae, Semen Armeniacae Amarum, Semen Phaseoli mix homogeneously in rustless steel container, and put into pulverizer, be ground into thin
Cross 100-120 mesh sieve after powder, recycle airflow pulverization, it is carried out fining-off so that it is reach 300-350 mesh；
3), step 2 gained mixture is added in mixer with caramel, collagen protein, Rhizoma Dioscoreae powder, after being sufficiently mixed, add
The mixing decoction liquor of step 1 gained is stirred soft material processed, stirs 15-20 minute；
4), by step 3 gains take out put stainless steel disc in pile up in heaps, surface pat smooth, cover tightly with non-woven fabrics, in temperature
For 30-35 DEG C, humidity 70-80%, ferment, after 3-4 days, treat that white mould clothing is uniformly born on stockpile surface, and crackle occurs, break
Cut-off mask when having cellular, fermented standby；
5) mixture, by step 4 fermented is whole broken, adds chitin mix homogeneously, puts in molding device, by molding device mark
Quasi-rule of operation operates, and is cut into the cubed pieces of the long 1.0-1.5cm of rib；
6), by step 5 gained cubed pieces, load in a clean rustless steel drip pan, pave, must not extrude, put into hot air circulation
Drying in baking oven, operate according to heated-air circulation oven standard operating procedure, baking temperature is 70-80 DEG C, when being dried
Between be 4-5 hour, water content control is at 7-12%, after drying, takes out, cools, loads in clean container, use outer, interior two layers multiple
Closing the form of packaging, internal layer packaging is non-toxic polyethylene bag, and outer packaging is corrugated case, kept dry.
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| CN201610642868.0A CN106075409A (en) | 2016-08-09 | 2016-08-09 | A kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces and preparation method thereof |
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| CN201610642868.0A CN106075409A (en) | 2016-08-09 | 2016-08-09 | A kind of antiinflammatory removing heat-phlegm micro-ferment Fructus Momordicae decoction pieces and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1757317A (en) * | 2005-09-17 | 2006-04-12 | 张志祥 | Momordica grosvenori tablets, and its prepn. method |
| CN101285027A (en) * | 2008-06-04 | 2008-10-15 | 桂林亦元生现代生物技术有限公司 | Fermented fresh fructus momordicae wine and brewing process thereof |
| CN104324103A (en) * | 2014-10-17 | 2015-02-04 | 磐安县道地磐药中药研究所 | Medicated leaven pure powder superfine decoction piece and preparation method thereof |
| CN105685717A (en) * | 2014-11-25 | 2016-06-22 | 黑龙江省智诚医药科技有限公司 | Fructus Momordicae health drink used for heat clearing and lung moistening, and production method thereof |
-
2016
- 2016-08-09 CN CN201610642868.0A patent/CN106075409A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1757317A (en) * | 2005-09-17 | 2006-04-12 | 张志祥 | Momordica grosvenori tablets, and its prepn. method |
| CN101285027A (en) * | 2008-06-04 | 2008-10-15 | 桂林亦元生现代生物技术有限公司 | Fermented fresh fructus momordicae wine and brewing process thereof |
| CN101285027B (en) * | 2008-06-04 | 2011-11-09 | 桂林亦元生现代生物技术有限公司 | Fermented fresh fructus momordicae wine and brewing process thereof |
| CN104324103A (en) * | 2014-10-17 | 2015-02-04 | 磐安县道地磐药中药研究所 | Medicated leaven pure powder superfine decoction piece and preparation method thereof |
| CN105685717A (en) * | 2014-11-25 | 2016-06-22 | 黑龙江省智诚医药科技有限公司 | Fructus Momordicae health drink used for heat clearing and lung moistening, and production method thereof |
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Application publication date: 20161109 |