CN106075279A - A kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece and preparation method thereof - Google Patents
A kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece and preparation method thereof, be made up of following raw materials in part by weight: Radix Notoginseng 50 60, Radix Salviae Miltiorrhizae 13 15, the Radix Astragali 13 15, Oleum Sesami 13 15, rice bran protein powder 130 150, Semen Persicae 15 18, Semen Phaseoli 15 18, fishbone superfine powder 10 12, Radix Angelicae Sinensis 67, rice wine 30 35, Rhizoma Curcumae Longae 56, Flos Lonicerae 10 12.A kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece of the present invention, contained effective ingredient has the functions such as antiinflammatory, detumescence, pain relieving.
Description
Technical field
The present invention relates to prepared slices of Chinese crude drugs technical field, particularly relate to a kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece and preparation side thereof
Method.
Background technology
The prepared slices of Chinese crude drugs are under guidance of traditional Chinese medicine theory, according to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle and the needs of formulation dispensing, to Chinese medicine
The finished product of material Processing methods is tcm clinical practice medication, play dialectical plus-minus, embody the basis of personalized medicine principle.Chinese medicine is drunk
Sheet is one of big pillar of Chinese herbal medicine industry three, the important component part of Ye Shi China traditional medicine, diseases prevention, cure the disease in play
Important effect.Therefore the quality of The Quality of Sliced Herbal Medicine is by directly influencing the effect of tcm clinical practice treatment, has influence on the people
Masses' life and health and the safety of medication.
Chinese medicine wall cell disruption powder body and Chinese medicine wall cell disruption decoction pieces are the modern developments of Chinese medicinal powder application, the utilization rate of its material base
More traditional decoction pieces has a more substantial increase.Research work expands around association area and studies more than the tackling key problem of 300 sub-problems.
The Chinese crude drug overwhelming majority derives from natural plant, derives from animal, mineral and artifact on a small quantity.And plant medicine material
Being respectively provided with cell wall structure, use traditional decoction extracting mode, cell wall can stop intracellular active substance to a great extent
Dissolution, causes active ingredients from traditional Chinese medicinal utilization rate low, serious waste of resources.Chinese medicine wall cell disruption decoction pieces is broken by modern crushing technology
Cell wall, allows the material in cell wall be prone to dissolution and mix homogeneously, can be effectively improved Chinese crude drug because of its position and tissue etc. no
The problem of the material base inhomogeneities caused together, improves leaching rate and the utilization rate of effective ingredient in medical material, also achieves
Chinese medicine without long-time high temperature decoct extract process, and apply convenient.And in traditional Chinese herbs broken wall link, rational breaking cell wall
Diameter of particle is that it is crucial.The diameter of general cell is all about 10-100 μm.After being processed by cellular level pulverizing, in inciting somebody to action
Pulverizing medicinal materials is to 300 mesh (sieve aperture internal diameter is 47 μm), and cell-wall breaking ratio can reach 86.5%.The 300 above Chinese traditional powder of mesh, 98% is micro-
Powder can only see cell debris.The medium particle diameter that general 300 mesh Chinese medicinal powder microscope inspections measure is 4-10 μm.This grain
The ultrafine Chinese herb in footpath can make its components utilising rate improve to 60-90%.From economic and technical comprehensive examination and evaluation, Chinese medicine wall cell disruption decoction pieces selects
Selecting micronizing and be machined to D90 < 45 μm, < powder body of 45 μm (more than 300 mesh) breaks the diameter of particle of i.e. more than 90% as Chinese medicine
The standard of wall powder body.This breaking cell wall processes and belongs to fine physical refining process, intracellular material composition is not caused matter
Change.The wall breaking pulverization technology of Chinese medicine is the most mature in the industry two classes: one has rigid solid medium to participate in, by hitting
Hit, shear, the conventional size reduction principle such as friction breaks the technology of cell wall；Two do not have rigid solid medium to participate in, and utilize strong
Strong air-flow breaks the technology of cell wall by Chinese traditional powder self high frequency, fast ram.The pulverizing skill that rigid solid medium participates in
The feature of art is: medium, owing to being clashed into and rubbing, easy to wear comes off, and pollutes medical material；When medium high-speed impact, shearing medical material
, make medical material produce higher temperature, be unfavorable for the protection of heat-sensitive ingredients；But the subject range width that this technology is to medical material, to material
Physical property requires low.The feature of airflow pulverization is: do not have rigid solid medium contacting material, the suction of air-flow high speed pay-out
The heat production of heat and material impacting is offset, and material does not heats up at crushing process, so that heat-sensitive ingredients is effectively protected；But air-flow
The physical property of material is required higher by crushing technology, and subject range is narrower.For ensureing to greatest extent to process through cell wall breaking
Chinese traditional powder pollution-free, do not heat up, Chinese medicine wall cell disruption decoction pieces select airflow pulverization realize breaking cell wall.Chinese medicine wall cell disruption decoction pieces
After wall breaking pulverization processes, define the specific surface area moisture absorption big, easy, oxidizable and the powder body of poor fluidity, extremely unstable and difficulty
To meet the industrialized production requirement to its mobility.Therefore, allow Chinese medicine wall cell disruption powder body after breaking cellular wall again molding with reduce ratio
Surface area, improves the key problem in technology that stability is exactly its industrialization.
Summary of the invention
The object of the invention is contemplated to make up the defect of prior art, it is provided that a kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece.
The present invention is achieved by the following technical solutions:
A kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece, is made up of following raw materials in part by weight:
Radix Notoginseng 50-60, Radix Salviae Miltiorrhizae 13-15, Radix Astragali 13-15, Oleum Sesami 13-15, rice bran protein powder 130-150, Semen Persicae 15-18, red little
Bean 15-18, fishbone superfine powder 10-12, Radix Angelicae Sinensis 6-7, rice wine 30-35, Rhizoma Curcumae Longae 5-6, Flos Lonicerae 10-12.
Described a kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece, is made up of the following step:
1), Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Curcumae Longae, Flos Lonicerae, rice wine being added in steamer, decoct altogether twice, the decoction liquor after filter takes
Go out, load in clean container；
2), by Radix Notoginseng, Semen Persicae, Semen Phaseoli mix homogeneously in rustless steel container, and pulverizer is put into, after being ground into fine powder
Cross 100-120 mesh sieve, recycle airflow pulverization, it is carried out fining-off so that it is reach 300-350 mesh；
3), step 2 gained mixture is added in mixer with Oleum Sesami, rice bran protein powder, fishbone superfine powder, wait to be sufficiently mixed
After, the mixing decoction liquor adding step 1 gained is stirred soft material processed, stirs 15-20 minute；
4), by step 3 gains take out put stainless steel disc in pile up in heaps, surface pat smooth, cover tightly with non-woven fabrics, in temperature
For 30-35 DEG C, humidity 70-80%, ferment, after 3-4 days, treat that white mould clothing is uniformly born on stockpile surface, and crackle occurs, break
Cut-off mask when having cellular, fermented standby；
5) mixture, by step 4 fermented is whole broken, puts in molding device, operates by molding device standard operating procedure, cuts
Become the cubed pieces of the long 1.0-1.5cm of rib；
6), by step 5 gained cubed pieces, load in a clean rustless steel drip pan, pave, must not extrude, put into hot air circulation
Drying in baking oven, operate according to heated-air circulation oven standard operating procedure, baking temperature is 70-80 DEG C, when being dried
Between be 4-5 hour, water content control is at 7-12%, after drying, takes out, cools, loads in clean container, use outer, interior two layers multiple
Closing the form of packaging, internal layer packaging is non-toxic polyethylene bag, and outer packaging is corrugated case, kept dry.
The invention have the advantage that
1, a kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece of the present invention, is pulverized material by airflow pulverization, the most just
Property solid dielectric contacting material, the heat production of the heat absorption of air-flow high speed pay-out and material impacting offsets, and material does not rises at crushing process
Temperature, so that heat-sensitive ingredients is effectively protected.
2, the present invention is by adding rice wine, extracts the Chinese medicines such as Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Curcumae Longae, Flos Lonicerae, not only
Be conducive to the leaching of effective ingredient, increase the distinctive sweet-smelling of rice wine, moreover it is possible to invigorate blood circulation, skin moistening, warming the stomach simultaneously.
3, a kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece of the present invention, replaces tradition by rice bran protein powder, fishbone superfine powder
Flour, it is moulding to carry out tabletting, and not only mouthfeel is more preferably, and nutrition is the most more rich.
4, a kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece of the present invention, contained effective ingredient has the merits such as antiinflammatory, detumescence, pain relieving
With.
Detailed description of the invention
A kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece, is made up of following raw materials in part by weight:
Radix Notoginseng 50, Radix Salviae Miltiorrhizae 13, the Radix Astragali 13, Oleum Sesami 13, rice bran protein powder 130, Semen Persicae 15, Semen Phaseoli 15, fishbone superfine powder 10, when
Return 6, rice wine 30, Rhizoma Curcumae Longae 5, Flos Lonicerae 10.
Described a kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece, is made up of the following step:
1), Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Curcumae Longae, Flos Lonicerae, rice wine being added in steamer, decoct altogether twice, the decoction liquor after filter takes
Go out, load in clean container；
2), by Radix Notoginseng, Semen Persicae, Semen Phaseoli mix homogeneously in rustless steel container, and pulverizer is put into, after being ground into fine powder
Cross 100 mesh sieves, recycle airflow pulverization, it is carried out fining-off so that it is reach 320 mesh；
3), step 2 gained mixture is added in mixer with Oleum Sesami, rice bran protein powder, fishbone superfine powder, wait to be sufficiently mixed
After, the mixing decoction liquor adding step 1 gained is stirred soft material processed, stirs 15 minutes；
4), by step 3 gains take out put stainless steel disc in pile up in heaps, surface pat smooth, cover tightly with non-woven fabrics, in temperature
It is 30 DEG C, humidity 70%, ferments, after 3 days, treat that white mould clothing is uniformly born on stockpile surface, and crackle occurs, break section tool into two with one's hands
When having cellular, ferment standby；
5) mixture, by step 4 fermented is whole broken, puts in molding device, operates by molding device standard operating procedure, cuts
Become the cubed pieces of the long 1.0cm of rib；
6), by step 5 gained cubed pieces, load in a clean rustless steel drip pan, pave, must not extrude, put into hot air circulation
Drying in baking oven, operate according to heated-air circulation oven standard operating procedure, baking temperature is 70 DEG C, and drying time is
4 hours, water content control was 7%, after drying, takes out, cools, and loaded in clean container, used outer, interior two layers of composite packaging
Form, internal layer packaging is non-toxic polyethylene bag, and outer packaging is corrugated case, kept dry.
Claims (2)
1. anti-inflammation detumescence micro-ferment notoginseng decoction piece, it is characterised in that be made up of following raw materials in part by weight:
Radix Notoginseng 50-60, Radix Salviae Miltiorrhizae 13-15, Radix Astragali 13-15, Oleum Sesami 13-15, rice bran protein powder 130-150, Semen Persicae 15-18, red little
Bean 15-18, fishbone superfine powder 10-12, Radix Angelicae Sinensis 6-7, rice wine 30-35, Rhizoma Curcumae Longae 5-6, Flos Lonicerae 10-12.
A kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece the most according to claim 1, it is characterised in that be made up of the following step
:
1), Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Curcumae Longae, Flos Lonicerae, rice wine being added in steamer, decoct altogether twice, the decoction liquor after filter takes
Go out, load in clean container；
2), by Radix Notoginseng, Semen Persicae, Semen Phaseoli mix homogeneously in rustless steel container, and pulverizer is put into, after being ground into fine powder
Cross 100-120 mesh sieve, recycle airflow pulverization, it is carried out fining-off so that it is reach 300-350 mesh
3), step 2 gained mixture is added in mixer with Oleum Sesami, rice bran protein powder, fishbone superfine powder, wait to be sufficiently mixed
After, the mixing decoction liquor adding step 1 gained is stirred soft material processed, stirs 15-20 minute；
4), by step 3 gains take out put stainless steel disc in pile up in heaps, surface pat smooth, cover tightly with non-woven fabrics, in temperature
For 30-35 DEG C, humidity 70-80%, ferment, after 3-4 days, treat that white mould clothing is uniformly born on stockpile surface, and crackle occurs, break
Cut-off mask when having cellular, fermented standby；
5) mixture, by step 4 fermented is whole broken, puts in molding device, operates by molding device standard operating procedure, cuts
Become the cubed pieces of the long 1.0-1.5cm of rib；
6), by step 5 gained cubed pieces, load in a clean rustless steel drip pan, pave, must not extrude, put into hot air circulation
Drying in baking oven, operate according to heated-air circulation oven standard operating procedure, baking temperature is 70-80 DEG C, when being dried
Between be 4-5 hour, water content control is at 7-12%, after drying, takes out, cools, loads in clean container, use outer, interior two layers multiple
Closing the form of packaging, internal layer packaging is non-toxic polyethylene bag, and outer packaging is corrugated case, kept dry.
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| CN201610420134.8A CN106075279A (en) | 2016-06-16 | 2016-06-16 | A kind of anti-inflammation detumescence micro-ferment notoginseng decoction piece and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485717A (en) * | 2009-02-18 | 2009-07-22 | 由凤鸣 | Oral medication for treating pyogenic skin infection |
| CN101618055A (en) * | 2008-07-02 | 2010-01-06 | 文山三七药业股份有限公司 | Method for processing notoginseng decoction piece |
| CN101675946A (en) * | 2008-09-19 | 2010-03-24 | 天津天士力制药股份有限公司 | Application of a traditional Chinese medicine in preparing a medicine for reducing inflammatory reaction after PCI |
| CN104840518A (en) * | 2015-01-22 | 2015-08-19 | 梁成 | Oral Chinese patent medicine used for preventing and treating chilblain and frostbite |
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2016
- 2016-06-16 CN CN201610420134.8A patent/CN106075279A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618055A (en) * | 2008-07-02 | 2010-01-06 | 文山三七药业股份有限公司 | Method for processing notoginseng decoction piece |
| CN101675946A (en) * | 2008-09-19 | 2010-03-24 | 天津天士力制药股份有限公司 | Application of a traditional Chinese medicine in preparing a medicine for reducing inflammatory reaction after PCI |
| CN101485717A (en) * | 2009-02-18 | 2009-07-22 | 由凤鸣 | Oral medication for treating pyogenic skin infection |
| CN104840518A (en) * | 2015-01-22 | 2015-08-19 | 梁成 | Oral Chinese patent medicine used for preventing and treating chilblain and frostbite |
Non-Patent Citations (4)
| Title |
|---|
| 刘吉华: "《中药生物技术》", 31 October 2015, 中国医药科技出版社 * |
| 南京中医药大学: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
| 房定亚等: "《中成药临床应用指南》", 31 August 1994, 科学技术文献出版社 * |
| 陈长洲: "《微米中药—中药超细粉体的研究及应用》", 31 August 2007, 中国医药科技出版社 * |
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