CN104887721A - Ultramicro decoction pieces made of Ganoderma lucidum pure powders, method for preparing ultramicro decoction pieces and application of ultramicro decoction pieces - Google Patents
Ultramicro decoction pieces made of Ganoderma lucidum pure powders, method for preparing ultramicro decoction pieces and application of ultramicro decoction pieces Download PDFInfo
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Abstract
The invention discloses an ultramicro decoction pieces made of Ganoderma lucidum pure powders, a method for preparing ultramicro decoction pieces and the application of ultramicro decoction pieces. According to the method, fresh Ganoderma lucidum raw materials are cleaned, cut, quickly fried, roasted and crushed to prepare crude powders, and the crude powders are subjected to sterilization treatment. According to the method for preparing ultramicro decoction pieces, the time, the temperature and other parameters of the vacuum-freezing, sublimating and drying process are reasonably designed. In this way, the medicinal compositions of raw drugs and the performances of reductive crude drugs are maintained maximally. Based on the ultra-fine powder technique, the medicinal ingredients of Ganoderma lucidum can pass through crushed cell nucleus and cell walls to be fully and completely released.
Description
Technical field
The invention belongs to technical field of Chinese medicines, more specifically, the present invention relates to pure powder ultramicro decoction piece of a kind of Ganoderma and its preparation method and application.
Background technology
Ganoderma, as a kind of rare medicinal herbs, has protective effect to the hepatic injury that multiple physics and chemistry and biological factor cause.No matter before liver injury occurs or after generation, taking Ganoderma all can the liver protecting, alleviates hepatic injury.Ganoderma can promote that liver is to the metabolism of medicine, poisonous substance, has definite curative effect for toxic hepatitis.Especially chronic hepatitis, Ganoderma obviously can eliminate the symptoms such as dizziness, weak, nauseating, uncomfortable liver area, and effectively can improve liver function, makes indices be tending towards normal.So Ganoderma can be used for treating chronic poisoning, all kinds of chronic hepatitis, liver cirrhosis, hepatic insufficiency.
Ganoderma tradition decoction pieces according to factors such as conditions of patients changes, can be cut out flavour of a drug and dose flexibilityization thereof clinically, thus commercially very popular.
The needs of modern healthy, although defined the century-brand of numerous direct oral medicinal slice, traditional decoction pieces and new type health industry in field of traditional Chinese, as large in Tongrentang, Hu Qingyu Pharmaceutical Workshop, large raw auspicious (1885), Han Xingtang, Xing Hetang, public good, Chen Zhi father-in-law, Huai Dehe, old man and Tai, father-in-law Changchun, Fu Jichun, refined vegetarian, thunder have permitted first-class and century-old Tea containing traditional Chinese medicine brand as poly-in ten thousand safe unit (1860), Zhu Qiansheng, roc red sun, universe Thailand.But the decoction of Ganoderma tradition decoction pieces bothers, it is day by day serious to take the realistic problems such as inconvenience, quality is unstable, sanitary condition causes anxiety, the contradiction of its traditional advantage and its " uncertainty " and " inadaptability ", for this reason, China and other countries and regions using Ganoderma disease therapy more, Ganoderma tradition decoction pieces is all carried out in various degree, the reform of different directions research, in succession there is the new products such as single Ganoderma water preparation, granular pattern lucid ganoderma decoction piece, Ganoderma granule.Single Ganoderma water preparation feature is high containing cream leaching amount; Shortcoming ignores Ganoderma decoction group medicine to decoct impact on some drugs active ingredient stripping quantity altogether, and the inside must add antiseptic, is not suitable for applying.The feature of granular pattern decoction pieces is the stripping being conducive to active ingredient, can reduce medical material consumption; Shortcoming is that volatile ingredient easily loses, and still needs to decoct, take inconvenience, is also not suitable for large-scale popularization; Ganoderma granule active ingredient concentration is high, dose is little, directly can take after mixing it with water, extensively welcome by patient, but it is expensive, and the crowd that market can be consumed is few.
Micropowder technology is the interdiscipline occurred along with the development of modern science and technology after the sixties, inter-trade new and high technology, how this technology is introduced Ganoderma manufacture field, improve Ganoderma crude drug cell sporoderm-broken rate, increase specific surface area, make diameter of particle reach micron order, have very important realistic meaning to utilization rate, the medicament curative effect enhancement improving Ganoderma.
Summary of the invention
Based on this, main purpose of the present invention is to provide that a kind of stripping property is good, effective ingredient availability is high, and to pure powder ultramicro decoction piece of the Ganoderma that raw material usage is little and preparation method thereof, bring the technical problem of all inconvenience to solve Ganoderma tradition decoction pieces in the market.
For achieving the above object, this invention takes following technical scheme:
A preparation method for the pure powder ultramicro decoction piece of Ganoderma, comprises the following steps:
(1) after, being cleaned by fresh Ganoderma raw material, cutting, big gun process process;
(2), by the Ganoderma after process pulverize, make coarse powder, then carry out sterilization treatment;
(3), coarse powder Ganoderma is put into freeze drying box after, start freeze dryer, after freeze drying box temperature is down to-30 DEG C ~-35 DEG C, keep carrying out lyophilization in 1.5-3 hour;
(4), the system absolute pressure of being evacuated to is 60 ~ 100Pa, starts to be heated to 40 DEG C ~ 50 DEG C, sublimation drying 15 ~ 24 hours;
(5), by dried coarse powder Ganoderma add in ultrafine crusher and carry out beating powder, after beating powder, the particle diameter of the pure powder of described Ganoderma is 0.5-2 μm, obtains ultramicro decoction piece.
Wherein in an embodiment, by obtained ultramicro decoction piece with meet the adjuvant that medicament requires, obtained tablet, capsule or other oral normal release dosage forms.
Wherein in an embodiment, the preparation method of described tablet is: the adjuvant dextrin, the starch that micropowder and routine are made tablet mix, and granulation, tabletting, obtain tablet.
Wherein in an embodiment, the preparation method of described capsule is: mixed by the adjuvant Pulvis Talci that micropowder and routine make capsule, incapsulate, obtain capsule.
Wherein in an embodiment, after described in step (3), freeze drying box temperature is down to-35 DEG C, keep 3 hours.
Wherein in an embodiment, described in step (4), baking temperature is 45 DEG C, and baking temperature is 24 hours.Sublimation drying is most important operation in vacuum lyophilization process, need in sublimation process constantly to supplement latent heat of sublimation, and ensureing that the temperature at distillation interface is lower than below temperature of eutectic point, eutectic point refers to that the temperature melted just has appearred in the material of fully charge its ice crystal in heating process.So the Controlling principle of lyophilization stepwise heating temperature is: make sublimation temperature close to its eutectic point but must lower than eutectic point as far as possible, if the product of distillation is too much lower than temperature of eutectic point, the rate reduction then distilled, the time of sublimation stage can extend, and active ingredient will be run off; The phenomenons such as if higher than temperature of eutectic point, then product can melt, and dried product volume-diminished will occur, and occur bubble, color burn, rehydration reduction difficulty.
Wherein in some embodiments, step is beaten after powder through ultrafine crusher in (5), and the particle diameter of the pure powder of described Ganoderma is 0.5-1 μm.
Wherein in an embodiment, beat after powder through ultrafine crusher, the particle diameter of the pure powder of described Ganoderma is 0.5-0.6 μm.
Wherein in some embodiments, sterilization treatment described in step (2) be ray sterilizing, microwave sterilizating, wet-hot steam sterilizing or ozone sterilization one or more.
Present invention also offers the application of the pure powder ultramicro decoction piece of above-mentioned Ganoderma in the medicine of preparation treatment chronic poisoning, chronic hepatitis, liver cirrhosis or hepatic insufficiency.
The preparation principle of the pure powder ultramicro decoction piece of Ganoderma of the present invention is: adopt vacuum lyophilization, the active ingredient of former medicine can be preserved to greatest extent and go back the performance of crude drug in whole, adopt ultrafine powder technology that the prepared slices of Chinese crude drugs are ground into superfine powder, medical material plant cell wall breaking rate is improved, be conducive to the stripping of its active ingredient, increase the specific surface area of medicine, its absorption rate and absorbtivity are increased.
Compared with the preparation method of the pure powder ultramicro decoction piece of traditional Ganoderma, the preparation method of Ganoderma of the present invention pure powder ultramicro decoction piece has following beneficial effect:
In the preparation method of 1, the pure powder ultramicro decoction piece of Ganoderma of the present invention, reasonably designed by parameters such as the time to vacuum freezing, sublimation drying, temperature, the active ingredient of former medicine can be preserved to greatest extent and go back the performance of crude drug in whole, after testing, the effective ingredient-use rate of finished product Ganoderma pure powder ultramicro decoction piece is equivalent to 5 times of traditional decoction pieces.
In the preparation method of 2, the pure powder ultramicro decoction piece of Ganoderma of the present invention, by adopting ultrafine powder technology, improve Ganoderma crude drug cell sporoderm-broken rate, increase specific surface area, diameter of particle is made to reach micron order (0.5-2 μm), the efficacy component of Ganoderma through the nucleus of fragmentation and cell wall, can be discharged fully completely, have very important realistic meaning to utilization rate, the medicament curative effect enhancement improving Ganoderma.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, the present invention is further elaborated.
The preparation method of the tablet of the pure powder ultramicro decoction piece of embodiment 1 one kinds of Ganodermas
Comprise the following steps:
(1), fresh Ganoderma material depth cleaning, cutting, big gun are processed process;
(2), by the Ganoderma after process pulverize, make coarse powder, then carry out wet-hot steam sterilization treatment;
(3), coarse powder Ganoderma is put into freeze drying box after, start freeze dryer, after freeze drying box temperature is down to-35 DEG C, keep 3 hours;
(4), the system absolute pressure of being evacuated to is 85Pa, starts to be heated to 45 DEG C, sublimation drying 24 hours;
(5), by dried coarse powder Ganoderma add in ultrafine crusher and carry out beating powder, after beating powder, the particle diameter of the pure powder of described Ganoderma is 0.5 μm; Obtain ultramicro decoction piece.
(6), by Ganoderma fine powder adopt conventional method tabletting, obtain tablet.
The tablet of the pure powder ultramicro decoction piece of the Ganoderma of making, size is even, and color and luster is consistent, without phenomenons such as the moisture absorption, caking, deliquescence.Measuring its moisture according to aquametry (China's coastal port annex IX H second method) is 4%; Check according to microbial limit algoscopy (" Chinese Pharmacopoeia " annex XIIIC), meet relevant regulations.
The preparation method of the tablet of the pure powder ultramicro decoction piece of embodiment 2 one kinds of Ganodermas
Comprise the following steps:
(1), fresh Ganoderma material depth cleaning, cutting, big gun are processed process;
(2), by the Ganoderma after process pulverize, make coarse powder, then carry out ray sterilizing process;
(3), coarse powder Ganoderma is put into freeze drying box after, start freeze dryer, after freeze drying box temperature is down to-30 DEG C, keep 2 hours;
(4), the system absolute pressure of being evacuated to is 60Pa, starts to be heated to 50 DEG C, sublimation drying 18 hours;
(5), by dried coarse powder Ganoderma add in ultrafine crusher and carry out beating powder, the particle diameter of the pure powder of described Ganoderma is 0.8 μm;
(6), by Ganoderma fine powder adopt conventional method tabletting, obtain tablet.
The pure powder ultramicro decoction piece of the Ganoderma of making, size is even, and color and luster is consistent, without phenomenons such as the moisture absorption, caking, deliquescence.Measuring its moisture according to aquametry (China's coastal port annex IX H second method) is 6%; Check according to microbial limit algoscopy (" Chinese Pharmacopoeia " annex XIIIC), meet relevant regulations.
The preparation method of the capsule of the pure powder ultramicro decoction piece of embodiment 3 one kinds of Ganodermas
Comprise the following steps:
(1), fresh Ganoderma material depth cleaning, cutting, big gun are processed process;
(2), by the Ganoderma after process pulverize, make coarse powder, then carry out sterilization treatment;
(3), coarse powder Ganoderma is put into freeze drying box after, start freeze dryer, after freeze drying box temperature is down to-32 DEG C, keep 1.5 hours;
(4), the system absolute pressure of being evacuated to is 60Pa, starts to be heated to 40 DEG C, sublimation drying 18 hours;
(5), by dried coarse powder Ganoderma add in ultrafine crusher and carry out beating powder, the particle diameter of the pure powder of described Ganoderma is 1 μm;
(6), by Ganoderma fine powder adopt conventional method to make capsule, obtain capsule.
The pure powder ultramicro decoction piece of the Ganoderma of making, size is even, and color and luster is consistent, without phenomenons such as the moisture absorption, caking, deliquescence.Measuring its moisture according to aquametry (China's coastal port annex IX H second method) is 5%; Check according to microbial limit algoscopy (" Chinese Pharmacopoeia " annex XIIIC), meet relevant regulations.
Comparative example 1
The preparation method of this comparative example is not except having ultra micro treatment technology (i.e. step 5), and other steps are all identical with the step of the preparation method of embodiment 1.
Comparative example 2
The preparation method of this comparative example is not except having Freeze Drying Technique (i.e. step 3 and 4), and other steps are all identical with the step of the preparation method of embodiment 1.
Comparative example 3
The preparation method of this comparative example is not except having Freeze Drying Technique, ultra micro treatment technology (i.e. step 3,4 and 5), and other steps are all identical with the step of the preparation method of embodiment 1.
The detection of the effective ingredient of the decoction pieces of test example 1 embodiment 1 and comparative example 1-3
Detected finished product decoction pieces effective ingredient by ultraviolet-visible spectrophotometer, testing result is as follows:
From testing result, adopt the decoction pieces that the preparation method of the pure powder ultramicro decoction piece of Ganoderma of the present invention prepares, compared with the traditional method in comparative example 1-3, effective ingredient is more than 5 times of traditional method; It can thus be appreciated that the preparation method of the present invention that employing Freeze Drying Technique, ultra micro treatment technology combine, the efficacy component of Ganoderma through the nucleus of fragmentation and cell wall, can discharge fully completely.
Test example 2 embodiment 1 detects the therapeutic effect of hepatic insufficiency with the decoction pieces of comparative example 1-3
Adopt randomized clinical research method, design completes 386 routine hepatic insufficiency clinical cases observations altogether, and wherein curative effect of disease criterion is with reference to " new Chinese medicine guideline of clinical investigations ", formulates in conjunction with " up-to-date domestic and international disease treatment standard " and pharmic function.It is the results detailed in Table 1.
The decoction pieces of table 1 embodiment 1 and comparative example 1-3 is to the therapeutic effect of hepatic insufficiency
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate |
| Embodiment 1 | 95 | 15 | 25 | 50 | 5 | 94.74％ |
| Matched group 1 | 98 | 8 | 15 | 50 | 25 | 74.49％ |
| Matched group 2 | 97 | 8 | 13 | 40 | 36 | 62.88％ |
| Matched group 3 | 96 | 8 | 19 | 45 | 24 | 75.0％ |
As can be seen from Table 1, the treated effect of embodiment 1 is 94.74%, higher than the effective percentage of comparative example 1-3 a lot.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.
In a word, the foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to the covering scope of patent of the present invention.
Claims (10)
1. a preparation method for the pure powder ultramicro decoction piece of Ganoderma, is characterized in that, comprise the following steps:
(1) after, being cleaned by fresh Ganoderma raw material, cutting, big gun process process;
(2), by the Ganoderma after process pulverize, make coarse powder, then carry out sterilization treatment;
(3), coarse powder Ganoderma is put into freeze drying box after, start freeze dryer, after freeze drying box temperature is down to-30 DEG C ~-35 DEG C, keep carrying out lyophilization in 1.5-3 hour;
(4), the system absolute pressure of being evacuated to is 60 ~ 100Pa, starts to be heated to 40 DEG C ~ 50 DEG C, sublimation drying 15 ~ 24 hours;
(5), by dried coarse powder Ganoderma add in ultrafine crusher and carry out beating powder, after beating powder, the particle diameter of the pure powder of described Ganoderma is 0.5-2 μm, obtains ultramicro decoction piece.
2. the preparation method of the pure powder ultramicro decoction piece of Ganoderma according to claim 1, is characterized in that, by obtained ultramicro decoction piece with meet the adjuvant that medicament requires, obtained tablet, capsule or other oral normal release dosage forms.
3. the preparation method of the pure powder ultramicro decoction piece of Ganoderma according to claim 2, is characterized in that, the preparation method of described tablet is: the adjuvant dextrin, the starch that micropowder and routine are made tablet mix, and granulation, tabletting, obtain tablet.
4. the preparation method of the pure powder ultramicro decoction piece of Ganoderma according to claim 2, is characterized in that, the preparation method of described capsule is: mixed by the adjuvant Pulvis Talci that micropowder and routine make capsule, incapsulate, obtain capsule.
5. the preparation method of the pure powder ultramicro decoction piece of Ganoderma according to claim 1, is characterized in that, after described in step (3), freeze drying box temperature is down to-35 DEG C, keeps 3 hours.
6. the preparation method of the pure powder ultramicro decoction piece of Ganoderma according to claim 1, is characterized in that, described in step (4), baking temperature is 45 DEG C, and baking temperature is 24 hours.
7. the preparation method of the pure powder ultramicro decoction piece of Ganoderma according to claim 1, is characterized in that, step is beaten after powder through ultrafine crusher in (5), and particle diameter is 0.5-1 μm.
8. the preparation method of the pure powder ultramicro decoction piece of Ganoderma according to claim 1, is characterized in that, sterilization treatment described in step (2) be ray sterilizing, microwave sterilizating, wet-hot steam sterilizing or ozone sterilization one or more.
9. the pure powder ultramicro decoction piece of Ganoderma that the preparation method of the pure powder of the Ganoderma described in any one of claim 1-8 ultramicro decoction piece prepares.
10. the application of the pure powder ultramicro decoction piece of Ganoderma according to claim 9 in the medicine of preparation treatment chronic poisoning, chronic hepatitis, liver cirrhosis or hepatic insufficiency.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105285970A (en) * | 2015-11-03 | 2016-02-03 | 四川峨眉仙山中药有限公司 | Refrigerating processing technology of glossy ganoderma powder |
| CN106237037A (en) * | 2016-09-13 | 2016-12-21 | 云南瑞药金方现代中药有限公司 | A kind of preparation method of sanguis draconis leaves breaking cellular wall decoction pieces |
| CN106309512A (en) * | 2016-09-13 | 2017-01-11 | 云南瑞药金方现代中药有限公司 | Method for preparing ganoderma wall-broken decoction pieces |
| CN106344632A (en) * | 2016-09-13 | 2017-01-25 | 云南瑞药金方现代中药有限公司 | Method for preparing wall-broken decoction pieces with balanophora involucrata |
| CN106362038A (en) * | 2016-09-13 | 2017-02-01 | 云南瑞药金方现代中药有限公司 | Preparation technology of wall-breaking decoction piece |
| CN106979947A (en) * | 2016-05-21 | 2017-07-25 | 广州今典精方药业有限公司 | The quality standard and manufacturing process of the ganoderma lucidum qualitative, quantitative prepared slices of Chinese crude drugs |
| CN109010385A (en) * | 2018-09-13 | 2018-12-18 | 杭州康力食品有限公司 | A kind of preparation method of glossy ganoderma powder |
| CN110353141A (en) * | 2018-06-15 | 2019-10-22 | 蔡晓鹏 | A kind of mulberries freeze-drying Chinese herbal medicine formula granule pieces and preparation method thereof |
| CN110934896A (en) * | 2019-12-31 | 2020-03-31 | 普洱淞茂滇草六味制药股份有限公司 | Preparation method of wild ganoderma lucidum wall-broken decoction pieces |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105285970A (en) * | 2015-11-03 | 2016-02-03 | 四川峨眉仙山中药有限公司 | Refrigerating processing technology of glossy ganoderma powder |
| CN106979947A (en) * | 2016-05-21 | 2017-07-25 | 广州今典精方药业有限公司 | The quality standard and manufacturing process of the ganoderma lucidum qualitative, quantitative prepared slices of Chinese crude drugs |
| CN106237037A (en) * | 2016-09-13 | 2016-12-21 | 云南瑞药金方现代中药有限公司 | A kind of preparation method of sanguis draconis leaves breaking cellular wall decoction pieces |
| CN106309512A (en) * | 2016-09-13 | 2017-01-11 | 云南瑞药金方现代中药有限公司 | Method for preparing ganoderma wall-broken decoction pieces |
| CN106344632A (en) * | 2016-09-13 | 2017-01-25 | 云南瑞药金方现代中药有限公司 | Method for preparing wall-broken decoction pieces with balanophora involucrata |
| CN106362038A (en) * | 2016-09-13 | 2017-02-01 | 云南瑞药金方现代中药有限公司 | Preparation technology of wall-breaking decoction piece |
| CN110353141A (en) * | 2018-06-15 | 2019-10-22 | 蔡晓鹏 | A kind of mulberries freeze-drying Chinese herbal medicine formula granule pieces and preparation method thereof |
| CN109010385A (en) * | 2018-09-13 | 2018-12-18 | 杭州康力食品有限公司 | A kind of preparation method of glossy ganoderma powder |
| CN109010385B (en) * | 2018-09-13 | 2021-07-27 | 杭州康力食品有限公司 | Preparation method of ganoderma lucidum powder |
| CN110934896A (en) * | 2019-12-31 | 2020-03-31 | 普洱淞茂滇草六味制药股份有限公司 | Preparation method of wild ganoderma lucidum wall-broken decoction pieces |
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