CN104225006A - Traditional Chinese medicine composition capable of invigorating Qi and relaxing bowels - Google Patents
Traditional Chinese medicine composition capable of invigorating Qi and relaxing bowels Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition capable of invigorating Qi and relaxing the bowels. An effective ingredient of the composition consists of cassia seed or an extract thereof, tangerine peel or an extract thereof, ginseng or an extract thereof and radish seed or an extract thereof. The traditional Chinese medicine composition can be used for treating constipation and has beneficial effects, which are unmatchable by single preparations, when the traditional Chinese medicine composition acts on human bodies. The traditional Chinese medicine composition is simple in production process, easy in oral taking and remarkable in treatment effect, thereby being an ideal traditional Chinese medicine composition for improving the sleeping of the human bodies.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to one and there is loosening bowel to relieve constipation, the Chinese medicine composition for the treatment of constipation.
Background technology
The prevalence of constipation in crowd is up to 27%, and constipation can affect the people of each age group.In constipation crowd, women is more than male, old more than blue or green, the prime of life.Because constipation sickness rate is high, the cause of disease is complicated, patient often has manifold vexations, and can affect quality of life when constipation is serious.Constipation often shows as: awareness of defecation is few, just secondary also few; Defecation is difficult, effort; Defecation is not smooth; Constipation with dry stool, hard just, defecation is not felt only; Constipation is with stomachache or abdominal discomfort.Some patients is also with Behavioral disturbances such as insomnia, agitation, dreaminess, depression, anxieties.
In the medicine of current treatment constipation, in, western drug all has, but clinical observation finds that effect is not all very desirable, as how sought more effective medicine to internal medicine constipation, how sequela etc. is overcome to surgery constipation and there is an a lot of difficult problem, great majority have been assosting effects of short-term, can not thoroughly treat.
Summary of the invention
The object of the invention is to provide one to have loosening bowel to relieve constipation for above-mentioned technical problem, the Chinese medicine composition for the treatment of constipation, the effective ingredient Wei Decision pine torch of this Chinese medicine composition or its extract, Pericarpium Citri Reticulatae or its extract, ginseng or its extract and Semen Raphani or its extract, by the mutual synergistic function between component, to treatment constipation.
Object of the present invention can be achieved through the following technical solutions:
A Chinese medicine composition for QI invigorating relieving constipation, this Chinese medicine composition effective ingredient Wei Decision pine torch, Pericarpium Citri Reticulatae, ginseng and Semen Raphani, and according to raw material composition: Decision pine torch 1-90 part of following weight parts, Pericarpium Citri Reticulatae 1-80 part, ginseng 1-90 part and Semen Raphani 1-85 part; Preferably the parts by weight of the effective ingredient Zhong Decision pine torch of this Chinese medicine composition, Pericarpium Citri Reticulatae, ginseng and Semen Raphani are followed successively by 2-75 part, 2-70 part, 4-75 part and 3-70 part; Further preferably the parts by weight of the effective ingredient Zhong Decision pine torch of this Chinese medicine composition, Pericarpium Citri Reticulatae, ginseng and Semen Raphani are followed successively by 25-35 part, 5-15 part, 35-45 part and 15-25 part; Most preferably the parts by weight of the effective ingredient Zhong Decision pine torch of this Chinese medicine composition, Pericarpium Citri Reticulatae, ginseng and Semen Raphani are followed successively by 30 parts, 10 parts, 40 parts and 20 parts.
A Chinese medicine composition for QI invigorating relieving constipation, said composition can also be any one of following combination:
The effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch extract, 1-80 part Pericarpium Citri Reticulatae, 1-90 part ginseng and 1-85 part Semen Raphani; Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch, 1-80 part Pericarpium Citri Reticulatae extract, 1-90 part ginseng and 1-85 part Semen Raphani; Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch, 1-80 part Pericarpium Citri Reticulatae, 1-90 part conopsea extraction and 1-85 part Semen Raphani; Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch, 1-80 part Pericarpium Citri Reticulatae, 1-90 part ginseng and 1-85 part Semen Raphani extract;
Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch extract, 1-80 part Pericarpium Citri Reticulatae extract, 1-90 part ginseng and 1-85 part Semen Raphani; Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch extract, 1-80 part Pericarpium Citri Reticulatae, 1-90 part conopsea extraction and 1-85 part Semen Raphani; Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch extract, 1-80 part Pericarpium Citri Reticulatae, 1-90 part ginseng and 1-85 part Semen Raphani extract; Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch, 1-80 part Pericarpium Citri Reticulatae extract, 1-90 part conopsea extraction and 1-85 part Semen Raphani; Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch, 1-80 part Pericarpium Citri Reticulatae extract, 1-90 part ginseng and 1-85 part Semen Raphani extract; Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch, 1-80 part Pericarpium Citri Reticulatae, 1-90 part conopsea extraction and 1-85 part Semen Raphani extract;
Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch extract, 1-80 part Pericarpium Citri Reticulatae extract, 1-90 part conopsea extraction and 1-85 part Semen Raphani; Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch extract, 1-80 part Pericarpium Citri Reticulatae extract, 1-90 part ginseng and 1-85 part Semen Raphani extract; Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch, 1-80 part Pericarpium Citri Reticulatae extract, 1-90 part conopsea extraction and 1-85 part Semen Raphani extract;
Or the effective ingredient of this Chinese medicine composition is 1-90 Fen Decision pine torch extract, 1-80 part Pericarpium Citri Reticulatae extract, 1-90 part conopsea extraction and 1-85 part Semen Raphani extract.
The parts by weight of the effective ingredient Zhong ， Decision pine torch of the above-mentioned Chinese medicine composition containing extract or its extract, Pericarpium Citri Reticulatae or its extract, ginseng or its extract and Semen Raphani or its extract are followed successively by 2-75 part, 2-70 part, 4-75 part and 3-70 part.
Shang Shu Decision pine torch extract is Decision pine torch water or the extract of organic solvent that dissolves each other with water; The extract of organic solvent that Pericarpium Citri Reticulatae extract is Pericarpium Citri Reticulatae water or dissolves each other with water; The extract of organic solvent that conopsea extraction is ginseng water or dissolves each other with water; The extract of organic solvent that Semen Raphani extract is Semen Raphani water or dissolves each other with water.
Water extract described in technical solution of the present invention component is carried out dissolving to extract using water as solvent, concentrates and the extract of formation; The extract of the organic solvent dissolved each other with water described in technical solution of the present invention is extracted for solvent carries out dissolving with the mixture of water and organic solvent component, the concentrated and extract of the organic solvent dissolved each other with water that formed.
The above-mentioned organic solvent dissolved each other with water is any one in methanol, ethanol, acetone.
Above-mentioned obtain extracting method that extract adopts be decoct in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects any one or a few.
After the extract mixing of the compositions described in technical solution of the present invention or compositions, add the acceptable adjuvant of pharmaceutics, make clinical acceptable dosage form; Described dosage form is the preparation of peroral dosage form, Tabules or capsule formulation.
The Chinese medicine composition of the QI invigorating relieving constipation described in technical solution of the present invention has loosening bowel to relieve constipation in preparation, the purposes in treatment constipation health medicine.
Semen Cassiae described in technical solution of the present invention is the dry mature seed of leguminous plant Semen Cassiae or little Semen Cassiae.Described Semen Cassiae comprises after processing is refined Semen Cassiae extract, various forms after grinding in Semen Cassiae fine powder or Semen Cassiae growth course.
Pericarpium Citri Reticulatae involved by technical solution of the present invention is the mature peel of rutaceae orange and variety thereof.Described Pericarpium Citri Reticulatae is comprised the tangerine peel powder after grinding, is obtained other processing forms of Pericarpium Citri Reticulatae extract or Pericarpium Citri Reticulatae by various processes.
Ginseng involved by technical solution of the present invention is any one in Radix Pseudostellariae, Radix Panacis Quinquefolii and Radix Ginseng.Described ginseng is comprised the ginseng powder after grinding, is obtained other processing forms of conopsea extraction or ginseng by various processes.
Semen Raphani involved by technical solution of the present invention is smoke or Semen Raphani after parch.Described Semen Raphani is comprised the Semen Raphani powder after grinding, is obtained other processing forms of Semen Raphani extract or Semen Raphani by various processes.
After in the present invention, the definition of " collaborative raising " can be understood as the combination of several medical material, its drug effect is relative to improve when being used alone; Drug effect is more lasting; Compositions produces beyond thought effect in new control or healthcare field.
Inventor is found by test, and compositions of the present invention has the function of QI invigorating relieving constipation.These single doses by after a certain proportion of compositions to the beneficial effect of human body effect be single dose incomparable.
Compositions of the present invention, can directly pulverize or through this area conventional extraction techniques if the Hydrolysis kinetics of decoction and alcohol sedimentation technique or ethanol extract from water precipitation is as the active component of the compositions for the treatment of.Described active component can make various pharmaceutical formulation with pharmaceutically acceptable carrier or excipient composition, as being how granular tablet, granule, capsule, or oral liquid etc.According to use needs, compositions of the present invention also can be processed into slow releasing preparation or quick releasing formulation.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.These carriers used or excipient can determine for the those of ordinary skill of pharmaceutical field.
The preparation method of oral liquid, can but be not only confined to following one, after active component is mixed, decoct with water, decoction liquor is filtered, obtain solution, obtain extractum by concentrated for gained solution, then gained extractum is dissolved in the concentration of extractum weight 5-10 times weight is in the ethanol water according to weighing scale 95%, is uniformly mixed, quantitative separating, obtains oral liquid formulations.
The preparation method of tablet is sieved by active component mixture, and after pulverizing at the auxiliary agent conventional with preparing tablet, fully mixing homogeneously, mistake 40-80 eye mesh screen, is pressed into tablet by tabletting by direct for dry powder machine.
The preparation technology of capsule preparations can be sieved by active component mixture, and after pulverizing at the auxiliary agent conventional with preparing tablet, fully mixing homogeneously, cross 40-80 eye mesh screen, by granulating, drying, fills with capsule, polishing after the operations such as granulate, packs, gets product.
Beneficial effect of the present invention:
The effective ingredient Wei Decision pine torch of Chinese medicine compositions of the present invention or its extract, Pericarpium Citri Reticulatae or its extract, ginseng or its extract and Semen Raphani or its extract, this Chinese medicine composition can QI invigorating relieving constipation, the beneficial effect of this Chinese medicine composition to human body effect be single dose incomparable.The production technology of this medicine is simple, be easy to take, evident in efficacy, be a kind of Chinese medicine composition of desirable QI invigorating relieving constipation.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but protection scope of the present invention is not limited thereto:
Embodiment 1
Crude drug composition: Decision pine torch water extract 70g, Pericarpium Citri Reticulatae water extract 30g, Radix Pseudostellariae water extract 60g and Semen Raphani water extract 60g.
Decision pine torch water extract is prepared: and Decision pine torch is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add 8 times that water inventory is total dose, after boiling, little fire boils state, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C of dry cream of) Zhi Decision pine torch and Wei Decision pine torch water extract;
Prepared by Pericarpium Citri Reticulatae water extract: Pericarpium Citri Reticulatae is soaked 40 minutes, the water surface, higher than raw material Chinese medicine, adds 8 times that water inventory is total dose, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decocts 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Pericarpium Citri Reticulatae water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of Pericarpium Citri Reticulatae;
Prepared by Radix Pseudostellariae water extract: Radix Pseudostellariae is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add 8 times that water inventory is total dose, after boiling, little fire boils state, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Radix Pseudostellariae water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of Radix Pseudostellariae;
Prepared by Semen Raphani water extract: Semen Raphani core is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add 8 times that water inventory is total dose, after boiling, little fire boils state, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Semen Raphani water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of Semen Raphani;
Last Decision pine torch water extract 70g, Pericarpium Citri Reticulatae water extract 30g, Radix Pseudostellariae water extract 60g and Semen Raphani water extract 60g to be mixed, the concentration of water-soluble extract gross weight 5-10 times weight is in the ethanol water according to weighing scale 95%, be uniformly mixed, quantitative separating, obtains oral liquid formulations.
Embodiment 2
Crude drug composition: Decision pine torch 70g, Pericarpium Citri Reticulatae 30g, Radix Pseudostellariae 60g and Semen Raphani 60g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 3
Crude drug composition: Decision pine torch extract 25g, Pericarpium Citri Reticulatae extract 15g, Radix Panacis Quinquefolii extract 45g and Semen Raphani extract 25g.
Decision pine torch ethanol extraction is prepared: and is adopted by Decision pine torch 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry ， get Decision pine torch extract.
Prepared by Pericarpium Citri Reticulatae ethanol extraction: adopted by Pericarpium Citri Reticulatae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Pericarpium Citri Reticulatae extract.
Prepared by Radix Panacis Quinquefolii ethanol extraction: adopted by Radix Panacis Quinquefolii 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Radix Panacis Quinquefolii extract.
Prepared by Semen Raphani ethanol extraction: adopted by Semen Raphani 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Semen Raphani extract.
Decision pine torch extract 25g, Pericarpium Citri Reticulatae extract 15g, Radix Panacis Quinquefolii extract 45g be dry, pulverize into fine powder respectively with Semen Raphani extract 25g, sieve, mixing, granulate, be pressed into tablet.
Embodiment 4
Crude drug composition: Decision pine torch 25g, Pericarpium Citri Reticulatae 15g, Radix Panacis Quinquefolii 45g and Semen Raphani 25g.Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 5
Crude drug composition: Decision pine torch extract 35g, Pericarpium Citri Reticulatae 5g, Radix Ginseng 35g and Semen Raphani 15g.
Decision pine torch adopts 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time by the preparation: of Decision pine torch extract, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry ， get Decision pine torch extract.
Qian Shu Decision pine torch extract 35g, Pericarpium Citri Reticulatae 5g, Radix Ginseng 35g and Semen Raphani 15g are ground into fine powder, sieve, mixing, adds the magnesium stearate of gross weight 2%, incapsulates.
Embodiment 6
Crude drug composition: Decision pine torch 35g, Pericarpium Citri Reticulatae 5g, Radix Ginseng 35g and Semen Raphani 15g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 7
Crude drug composition: Decision pine torch 30g, Pericarpium Citri Reticulatae extract 10g, Radix Pseudostellariae extract 40g and Semen Raphani 20g.
Prepared by Pericarpium Citri Reticulatae extract: adopted by Pericarpium Citri Reticulatae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Pericarpium Citri Reticulatae extract.
Prepared by Radix Pseudostellariae extract: adopted by Radix Pseudostellariae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Radix Pseudostellariae extract.
Decision pine torch 30g, Pericarpium Citri Reticulatae extract 10g, Radix Pseudostellariae extract 40g and Semen Raphani 20g mixing is broken into fine powder, sieves, add the magnesium stearate of gross weight 2%, incapsulate.
Embodiment 8
Crude drug composition: Decision pine torch 30g, Pericarpium Citri Reticulatae 10g, Radix Pseudostellariae 40g and Semen Raphani 20g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 9
Crude drug composition: Decision pine torch extract 75g, Pericarpium Citri Reticulatae extract 70g, Radix Panacis Quinquefolii extract 4g and Semen Raphani 3g.
Decision pine torch extract is prepared: and is adopted 10% ~ 90% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time Decision pine torch, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry ， get Decision pine torch extract.
Prepared by Pericarpium Citri Reticulatae extract: adopt 10% ~ 90% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time Pericarpium Citri Reticulatae, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Pericarpium Citri Reticulatae extract.
Prepared by Radix Panacis Quinquefolii extract: adopt 10% ~ 90% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time Radix Panacis Quinquefolii, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Radix Panacis Quinquefolii extract.
Decision pine torch extract 75g, Pericarpium Citri Reticulatae extract 70g, Radix Panacis Quinquefolii extract 4g and Semen Raphani 3g are dried and crushed into fine powder, sieve, mixing, granulate, be pressed into tablet.
Embodiment 10
Crude drug composition: Decision pine torch 75g, Pericarpium Citri Reticulatae 70g, Radix Panacis Quinquefolii 4g and Semen Raphani 3g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 11
Crude drug composition: Decision pine torch 2g, Pericarpium Citri Reticulatae 70g, Radix Ginseng extract 75g and Semen Raphani 3g.
Prepared by Radix Ginseng extract: adopt 10% ~ 90% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time Radix Ginseng, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Radix Ginseng extract.
Decision pine torch 2g, Pericarpium Citri Reticulatae 70g, Radix Ginseng extract 75g and Semen Raphani 3g mixing is broken into fine powder, sieves, add the magnesium stearate of gross weight 2%, incapsulate.
Embodiment 12
Crude drug composition: Decision pine torch 2g, Pericarpium Citri Reticulatae 70g, Radix Ginseng 75g and Semen Raphani 3g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 13
Crude drug composition: Decision pine torch 2g, Pericarpium Citri Reticulatae 2g, Radix Pseudostellariae extract 75g and Semen Raphani extract 70g.
Prepared by Radix Pseudostellariae extract: adopt 10% ~ 90% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time Radix Pseudostellariae, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Radix Pseudostellariae extract.
Prepared by Semen Raphani water extract: Semen Raphani is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add 8 times that water inventory is total dose, after boiling, little fire boils state, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Semen Raphani water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of Semen Raphani.
Be dried and crushed into fine powder after aforementioned component being mixed, sieve, mixing, granulate, be pressed into tablet.
Embodiment 14
Raw material composition: Decision pine torch 2g, Pericarpium Citri Reticulatae 2g, Radix Pseudostellariae 75g and Semen Raphani 70g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Technical solution of the present invention is on the impact of Constipation Model Mus:
Constipation type Establishment of mouse model: choose 60 Kunming mouses, male and female half and half, body weight 20 ~ 30g/ only, be divided into four groups, be respectively normal group, model group, Chinese medicine low dose group and Chinese medicine high dose group, by Chinese medicine low dose group, the mice of Chinese medicine high dose group and model group injects hydrochloric acid maca 2.4mg/kg every day, the mice received saline injection of Normal group, within every 2 days, record mice stool grain is ripe, Mouse Weight, with Chinese medicine low dose group, the average daily feces volume of mice of Chinese medicine high dose group and model group and Normal group have significant difference after, the success of constipation type Establishment of mouse model is described.
The important composition of technical solution of the present invention is on the impact of constipation type mice: inject distilled water every day to the mice of Normal group, the mice of model group injects distilled water every day, Chinese medicine low dose group injects the Chinese medicine composition (prepared by embodiment 3) of 20g/kg every day, the mice of Chinese medicine high dose group injects the Chinese medicine composition (prepared by embodiment 3) of 40g/kg every day, and the administration time of this experiment is 6 days.
The time that active carbon administration by gavage first melena is discharged.Mice fasting 24h after drug withdrawal, per os fills with 100mg/ml carbon suspensioning liquid 2ml.Timing from active carbon gavage is complete, record the time of discharging to first black grain from gavage, experimental result is as follows:
Table 1 Chinese medicine composition of the present invention is on the impact of mice with constipation
| Project | The weight (gram/day) of feces | The time (second) that first melena is discharged |
| Normal group | 12.2±3.1 | 183±35 |
| Model control group | 5.1±1.8 | 342±56 |
| Chinese medicine low dose group | 6.9±1.2 | 206±26 |
| Chinese medicine high dose group | 9.2±3.1 | 196±32 |
As can be seen from Table 1, the time that the mice of Normal group and the mice of model control group are discharged at first melena has larger difference, can be successfully established by perception model, from the contrast of model group and Chinese drug-treated group, adopt technical solution of the present invention Chinese medicine composition to after mice treatment, the efflux time of first the melena of mice feces amount that is short and that discharge is large, and namely the constipation of technical solution of the present invention to mice possesses certain curative effect.
Clinical observation
1) experimental subject
At Yancheng City hospital collection constipation patient, constipation patient is all do not understand for more than 4 days, and patient is also severe with abdominal distention, flushing rough, and halitosis is thirsty, the symptoms such as pelvic congestion.
2) method of administration and the course for the treatment of:
The oral embodiment of the present invention 1 ~ 14; Contrast: Decision pine torch; Semen Raphani; Decision pine torch+Semen Raphani (1:1); Decision pine torch+Semen Raphani+Radix Pseudostellariae (1:1:1); Decision pine torch+Semen Raphani+Pericarpium Citri Reticulatae (1:1:1)
The each 2.5g of oral liquid, every day 3 times; Each 3 of capsule, every day 3 times; The each 3g of tablet, every day 3 times.
Be a course for the treatment of with one month, it treats 3 courses for the treatment of.
3) criterion of therapeutical effect
Cure: free movement of the bowels, once a day, neither too hard, nor too soft;
Improve: free movement of the bowels, 1 ~ 2 day once, sometimes dry;
Invalid: not improve.
4) therapeutic evaluation
Table 2 prescription of the present invention is to the clinical observation of QI invigorating relieving constipation
| Compositions | Number of cases | Cure | Improve | Invalid | Total improvement rate |
| Embodiment 1 | 80 | 56 | 15 | 9 | 88.8％ |
| Embodiment 2 | 100 | 69 | 20 | 11 | 89.0％ |
| Embodiment 3 | 112 | 63 | 36 | 13 | 88.4％ |
| Embodiment 4 | 96 | 56 | 30 | 10 | 89.6％ |
| Embodiment 5 | 136 | 65 | 52 | 19 | 86.0％ |
| Embodiment 6 | 108 | 58 | 37 | 13 | 88.0％ |
| Embodiment 7 | 115 | 56 | 41 | 18 | 84.3％ |
| Embodiment 8 | 109 | 51 | 42 | 16 | 85.3％ |
| Embodiment 9 | 98 | 50 | 31 | 17 | 82.7％ |
| Embodiment 10 | 86 | 41 | 30 | 15 | 82.6％ |
| Embodiment 11 | 103 | 48 | 37 | 18 | 82.5％ |
| Embodiment 12 | 86 | 57 | 15 | 14 | 83.7％ |
| Embodiment 13 | 108 | 65 | 25 | 18 | 83.3％ |
| Embodiment 14 | 102 | 64 | 19 | 19 | 81.4％ |
| Semen Raphani | 40 | 8 | 12 | 20 | 50.0％ |
| Decision pine torch+Semen Raphani | 40 | 10 | 12 | 18 | 55.0％ |
| Decision pine torch+Semen Raphani+Radix Pseudostellariae | 40 | 12 | 13 | 15 | 62.5％ |
| Fructus Schisandrae Chinensis+Herba Epimedii+Semen Ziziphi Spinosae | 40 | 16 | 11 | 13 | 67.5％ |
As can be seen from Table 2, the Chinese medicine composition of technical solution of the present invention can treat constipation, and the beneficial effect of this Chinese medicine composition to human body effect be single dose incomparable.
Claims (10)
1. the Chinese medicine composition of a QI invigorating relieving constipation, it is characterized in that: the effective ingredient of this Chinese medicine composition Wei Decision pine torch, Pericarpium Citri Reticulatae, ginseng and Semen Raphani, and according to raw material composition: Decision pine torch 1-90 part of following weight parts, Pericarpium Citri Reticulatae 1-80 part, ginseng 1-90 part and Semen Raphani 1-85 part.
2. the Chinese medicine composition of QI invigorating relieving constipation according to claim 1, is characterized in that: Decision pine torch, Pericarpium Citri Reticulatae, the parts by weight of ginseng and Semen Raphani is followed successively by 2-75 part, 2-70 part, 4-75 part and 3-70 part.
3. the Chinese medicine composition of described QI invigorating relieving constipation according to claim 2, is characterized in that: Decision pine torch, Pericarpium Citri Reticulatae, the parts by weight of ginseng and Semen Raphani is followed successively by 25-35 part, 5-15 part, 35-45 part and 15-25 part.
4. the Chinese medicine composition of QI invigorating relieving constipation according to claim 3, is characterized in that: Decision pine torch, Pericarpium Citri Reticulatae, the parts by weight of ginseng and Semen Raphani is followed successively by 30 parts, 10 parts, 40 parts and 20 parts.
5. a Chinese medicine composition for the QI invigorating relieving constipation described in any one of claim 1-4, is characterized in that: in Decision pine torch, Pericarpium Citri Reticulatae, ginseng and Semen Raphani at least one with the form of its extract for effective ingredient.
6. the Chinese medicine composition of QI invigorating relieving constipation according to claim 5, is characterized in that: Decision pine torch extract is Decision pine torch water or the extract of organic solvent that dissolves each other with water; The extract of organic solvent that Pericarpium Citri Reticulatae extract is Pericarpium Citri Reticulatae water or dissolves each other with water; The extract of organic solvent that conopsea extraction is ginseng water or dissolves each other with water; The extract of organic solvent that Semen Raphani extract is Semen Raphani water or dissolves each other with water.
7. the Chinese medicine composition of QI invigorating relieving constipation according to claim 6, is characterized in that: the described organic solvent dissolved each other with water is any one in methanol, ethanol, acetone.
8. the Chinese medicine composition of QI invigorating relieving constipation according to claim 6, is characterized in that: extracting method be decoct in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects any one or a few.
9. the Chinese medicine composition of the improving water flood according to any one of claim 1-5, is characterized in that: after the extract mixing of described compositions or compositions, add the acceptable adjuvant of pharmaceutics, make clinical acceptable dosage form; Described dosage form is the preparation of peroral dosage form, Tabules or capsule formulation.
10. the Chinese medicine composition of the QI invigorating relieving constipation described in any one of claim 1-5 has loosening bowel to relieve constipation in preparation, the purposes in treatment constipation health medicine.
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| CN107373259A (en) * | 2017-08-23 | 2017-11-24 | 宁波甬鸿优尚餐饮有限公司 | One kind relaxes bowel Chinese herbal health-caring beverage and preparation method thereof |
| CN107440115A (en) * | 2017-07-27 | 2017-12-08 | 新疆京洲和合生物科技开发有限公司 | A kind of blood-enriching tranquillizing, the oral liquid to relax bowel and preparation method thereof |
| CN107536980A (en) * | 2017-09-28 | 2018-01-05 | 苟稳 | A kind of decoction of medicinal ingredients for treating constipation |
| CN108671055A (en) * | 2018-09-03 | 2018-10-19 | 杭州市红十字会医院 | A kind of Chinese medicine composition of spleen tonifying and fat and preparation method thereof |
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| CN102357198A (en) * | 2011-11-11 | 2012-02-22 | 赵君怡 | Chinese medicinal composition for treating constipation |
| CN103710242A (en) * | 2014-01-09 | 2014-04-09 | 江苏海昇药业有限公司 | Semen raphani and malt wine and preparation method thereof |
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| CN1954686A (en) * | 2006-10-30 | 2007-05-02 | 杨梅香 | Tea beverage for reducing blood fat and its preparation method |
| CN102357198A (en) * | 2011-11-11 | 2012-02-22 | 赵君怡 | Chinese medicinal composition for treating constipation |
| CN103710242A (en) * | 2014-01-09 | 2014-04-09 | 江苏海昇药业有限公司 | Semen raphani and malt wine and preparation method thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107440115A (en) * | 2017-07-27 | 2017-12-08 | 新疆京洲和合生物科技开发有限公司 | A kind of blood-enriching tranquillizing, the oral liquid to relax bowel and preparation method thereof |
| CN107373259A (en) * | 2017-08-23 | 2017-11-24 | 宁波甬鸿优尚餐饮有限公司 | One kind relaxes bowel Chinese herbal health-caring beverage and preparation method thereof |
| CN107536980A (en) * | 2017-09-28 | 2018-01-05 | 苟稳 | A kind of decoction of medicinal ingredients for treating constipation |
| CN108671055A (en) * | 2018-09-03 | 2018-10-19 | 杭州市红十字会医院 | A kind of Chinese medicine composition of spleen tonifying and fat and preparation method thereof |
| CN108704060A (en) * | 2018-09-03 | 2018-10-26 | 杭州市红十字会医院 | A kind of defaecation disappears the Chinese medicine composition and preparation method thereof of fat |
| CN109985115A (en) * | 2019-05-23 | 2019-07-09 | 河南中医药大学 | A kind of Chinese medicine tea bag for treating constipation |
| CN109985115B (en) * | 2019-05-23 | 2021-07-23 | 河南中医药大学 | Traditional Chinese medicine tea bag for treating constipation |
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