CN104224888A - Traditional Chinese medicinal composition used for strengthening bone - Google Patents
Traditional Chinese medicinal composition used for strengthening bone Download PDFInfo
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- CN104224888A CN104224888A CN201410445555.7A CN201410445555A CN104224888A CN 104224888 A CN104224888 A CN 104224888A CN 201410445555 A CN201410445555 A CN 201410445555A CN 104224888 A CN104224888 A CN 104224888A
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Abstract
The invention relates to a traditional Chinese medicinal composition used for strengthening bone. Effective ingredients of the traditional Chinese medicinal composition used for strengthening bone comprise cornu cervi or extract thereof, semen cuscutae or extract thereof, drynaria rhizome or extract thereof and herba epimedii or extract thereof. The traditional Chinese medicinal composition provided by the invention can be used for increasing bone mineral density and preventing osteoporosis and has the beneficial effect, which can not be reached by a single dose, to a human body. The traditional Chinese medicinal composition used for strengthening bone is simple in production process, easy to take, obvious in curative effect and ideal for increasing the bone mineral density and preventing osteoporosis.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for increasing bone density, prevention of osteoporosis disease.
Background technology
Bone density is an important symbol of bone mass, reflection osteoporosis degree, the important evidence of prediction fracture risk.In the world's osteoporosis conference in 2004 of international osteoporosis foundation (IFO), think after Univ Sheffield UK's WHO metabolic osteopathy research center Johnell etc. carries out meta-analysis to 12 clinical researches, no matter male, or women, bone density (BMD) is all very important risk of fractures factors.Osteoporosis carries out grading diagnosis: normal for BMD is within 1 standard deviation (SD) of adult normal's bone density meansigma methods; Osteopenia is that BMD compared with normal adult bone density average reduces by 1 ~ 2.5 standard deviation; Osteoporosis is that BMD compared with normal adult bone density average reduces more than 2.5 standard deviations; Serious osteoporosis is that BMD or BMC compared with normal adult bone density average reduces more than 2.5 standard deviations and with the fragility fractures of more than 1 or 1.
Osteoporosis is mainly divided into constitutional and Secondary cases, and constitutional is except idiopathic, and be divided into I type and II type, I type is also called postmenopausal osteoporosis, is high conversion type, and main cause is that estrogen lacks; II type is also called senile osteoporosis, is low conversion type, aging due to the age.Osteoporosis is caused by many factors, and its basic pathology mechanism is that in bone metabolism process, defect appears in bone resorption and osteoplastic coupling, causes alcium and phosphor metabolization in human body uneven, bone density is reduced gradually and the clinical symptoms that causes.
In the medicine of current osteoporosis, in, western drug all has, but clinical observation finds that effect is not all very desirable.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine composition for increasing bone density, prevention of osteoporosis disease for above-mentioned technical problem.
Object of the present invention can be achieved through the following technical solutions:
For a Chinese medicine composition for strong bone, the effective ingredient of this Chinese medicine composition is Cornu Cervi Pantotrichum, Semen Cuscutae, Rhizoma Drynariae, Herba Epimedii, and forms according to following weight percentage ratio: Cornu Cervi Pantotrichum 1-85 part, Semen Cuscutae 1-90 part, Rhizoma Drynariae 1-90 part and Herba Epimedii 1-95 part; Preferably in this Effective Component of Chinese Medicine, Cornu Cervi Pantotrichum 3-60 part, Semen Cuscutae 2-65 part, Rhizoma Drynariae 4-75 part and Herba Epimedii 3-80 part; Further in this Effective Component of Chinese Medicine preferred, 5 ~ 15 parts, Cornu Cervi Pantotrichum, Semen Cuscutae 5 ~ 15 parts, Rhizoma Drynariae 35 ~ 45 parts and Herba Epimedii 35 ~ 45 parts; Most preferably in this Effective Component of Chinese Medicine, 10 parts, Cornu Cervi Pantotrichum, Semen Cuscutae 10 parts, Rhizoma Drynariae 40 parts and Herba Epimedii 40 parts.
For a Chinese medicine composition for strong bone, said composition can also be any one of following combination:
The effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum extract of 1-85 part, 1-90 part Semen Cuscutae, 1-90 part Rhizoma Drynariae and 1-95 part Herba Epimedii; Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum of 1-85 part, 1-90 part Semen Cuscutae extract, 1-90 part Rhizoma Drynariae and 1-95 part Herba Epimedii; Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum of 1-85 part, 1-90 part Semen Cuscutae, 1-90 part Rhizoma Drynariae extract and 1-95 part Herba Epimedii; Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum of 1-85 part, 1-90 part Semen Cuscutae, 1-90 part Rhizoma Drynariae and 1-95 part Herba Epimedii extract;
Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum extract of 1-85 part, 1-90 part Semen Cuscutae extract, 1-90 part Rhizoma Drynariae and 1-95 part Herba Epimedii; Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum extract of 1-85 part, 1-90 part Semen Cuscutae, 1-90 part Rhizoma Drynariae extract and 1-95 part Herba Epimedii; Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum extract of 1-85 part, 1-90 part Semen Cuscutae, 1-90 part Rhizoma Drynariae and 1-95 part Herba Epimedii extract; Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum of 1-85 part, 1-90 part Semen Cuscutae extract, 1-90 part Rhizoma Drynariae extract and 1-95 part Herba Epimedii; Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum of 1-85 part, 1-90 part Semen Cuscutae extract, 1-90 part Rhizoma Drynariae and 1-95 part Herba Epimedii extract; Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum of 1-85 part, 1-90 part Semen Cuscutae, 1-90 part Rhizoma Drynariae extract and 1-95 part Herba Epimedii extract;
Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum extract of 1-85 part, 1-90 part Semen Cuscutae extract, 1-90 part Rhizoma Drynariae extract and 1-95 part Herba Epimedii; Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum extract of 1-85 part, 1-90 part Semen Cuscutae extract, 1-90 part Rhizoma Drynariae and 1-95 part Herba Epimedii extract; Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum of 1-85 part, 1-90 part Semen Cuscutae extract, 1-90 part Rhizoma Drynariae extract and 1-95 part Herba Epimedii extract;
Or the effective ingredient of this Chinese medicine composition is the Cornu Cervi Pantotrichum extract of 1-85 part, 1-90 part Semen Cuscutae extract, 1-90 part Rhizoma Drynariae extract and 1-95 part Herba Epimedii extract.
In the effective ingredient of the preferred above-mentioned Chinese medicine composition containing extract, Cornu Cervi Pantotrichum or its extract are 3-60 part, Semen Cuscutae or its extract are 2-65 part, Rhizoma Drynariae or its extract are 4-75 part and Herba Epimedii or its extract are 3-80 part.
The extract of organic solvent that above-mentioned Cornu Cervi Pantotrichum extract is Cornu Cervi Pantotrichum water or dissolves each other with water; The extract of organic solvent that Semen Cuscutae extract is Semen Cuscutae water or dissolves each other with water; The extract of organic solvent that Rhizoma Drynariae extract is osteomiosis moisturizing or dissolves each other with water; The extract of organic solvent that Herba Epimedii extract is Herba Epimedii water or dissolves each other with water.
Water extract described in technical solution of the present invention component is carried out dissolving to extract using water as solvent, concentrates and the extract of formation; The extract of the organic solvent dissolved each other with water described in technical solution of the present invention is extracted for solvent carries out dissolving with the mixture of water and organic solvent component, the concentrated and extract of the organic solvent dissolved each other with water that formed.
The above-mentioned organic solvent dissolved each other with water is any one in methanol, ethanol, acetone.
Above-mentioned obtain extracting method that extract adopts be decoct in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects any one or a few.
After the extract mixing of the Chinese medicine composition described in technical solution of the present invention or compositions, add the acceptable adjuvant of pharmaceutics, make clinical acceptable dosage form; Described dosage form is the preparation of peroral dosage form, Tabules or capsule formulation.
The Chinese medicine composition for strong bone described in technical solution of the present invention has strong skeleton in preparation, the purposes in releasing osteoporosis health medicine.
When Cornu Cervi Pantotrichum described in technical solution of the present invention refers to that the tender angle of stag does not grow up to os osseum, band fine hair, containing blood.Cornu Cervi Pantotrichum is a kind of valuable Chinese medicine, as tonic invigorator, is applicable to controlling weakness, neurasthenia etc.Cornu Cervi Pantotrichum is divided into sika deer velvet antler or cervus elaphus linnaeus, preferably adopts cervus elaphus linnaeus, and the Cornu Cervi Pantotrichum described in technical solution of the present invention comprises after processing is refined Cornu Cervi Pantotrichum extract, various forms after grinding in Cornu Cervi Pantotrichum fine powder or antler growth process.
The Herba Epimedii arrived involved in the present invention can be Berberidaceae plant Herba Epimedii, Epimedium sagittatum, E. Pubescens, or the dried leaves of Herba Epimedii.Herba Epimedii in the present invention hides the icariin, icariin I, Herba Epimedii A etc. that comprise the Herba Epimedii powder after grinding, pass through refinement.
The semen cuscatue spp arrived involved in the present invention is in Convolvulaceae, semen cuscatue spp, and Semen Cuscutae is a kind of valuable Chinese medicine, for the kidney invigorating and essence nourishing, and nourishing the liver to improve visual acuity.The waist knee joint muscles and bones that simultaneously can also be applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.Semen Cuscutae in the present invention is comprised the Semen Cuscutae fine powder after grinding, is obtained other processing forms of Semen Cuscutae extract or Semen Cuscutae by various processes.
The Davallia arrived involved in the present invention is in Davalliaceae, and Davallia, Rhizoma Drynariae is a kind of valuable Chinese medicine, for the kidney invigorating bone strengthening, continues and hinders pain relieving.Also can be used for lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone simultaneously; External treatment alopecia areata, vitiligo.Rhizoma Drynariae in the present invention is comprised the Rhizoma Drynariae fine powder after grinding, is obtained other processing forms of Rhizoma Drynariae extract or Rhizoma Drynariae by various processes.
After in the present invention, the definition of " collaborative raising " can be understood as the combination of several medical material, its drug effect is relative to improve when being used alone; Drug effect is more lasting; Compositions produces beyond thought effect in new control or healthcare field.
Inventor is found by test, and compositions of the present invention is for increasing bone density, prevention of osteoporosis disease.These single doses by after a certain proportion of compositions to the beneficial effect of human body effect be single dose incomparable.
Compositions of the present invention, can directly pulverize or through this area conventional extraction techniques if the Hydrolysis kinetics of decoction and alcohol sedimentation technique or ethanol extract from water precipitation is as the active component of the compositions for the treatment of.Described active component can make various pharmaceutical formulation with pharmaceutically acceptable carrier or excipient composition, as being how granular tablet, granule, capsule, or oral liquid etc.According to use needs, compositions of the present invention also can be processed into slow releasing preparation or quick releasing formulation.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.These carriers used or excipient can determine for the those of ordinary skill of pharmaceutical field.
The preparation method of oral liquid, can but be not only confined to following one, after active component is mixed, decoct with water, decoction liquor is filtered, obtain solution, obtain extractum by concentrated for gained solution, then gained extractum is dissolved in the concentration of extractum weight 5-10 times weight is in the ethanol water according to weighing scale 95%, is uniformly mixed, quantitative separating, obtains oral liquid formulations.
The preparation method of tablet is sieved by active component mixture, and after pulverizing at the auxiliary agent conventional with preparing tablet, fully mixing homogeneously, mistake 40-80 eye mesh screen, is pressed into tablet by tabletting by direct for dry powder machine.
The preparation technology of capsule preparations can be sieved by active component mixture, and after pulverizing at the auxiliary agent conventional with preparing tablet, fully mixing homogeneously, cross 40-80 eye mesh screen, by granulating, drying, fills with capsule, polishing after the operations such as granulate, packs, gets product.
The invention has the beneficial effects as follows:
The effective ingredient of pharmaceutical composition of the present invention is Cornu Cervi Pantotrichum or its extract, Semen Cuscutae or its extract, Rhizoma Drynariae or its extract and Herba Epimedii or its extract, this Chinese medicine composition may be used for increase bone density, prevention of osteoporosis disease, the beneficial effect of this Chinese medicine composition to human body effect be single dose incomparable.The production technology of this medicine is simple, be easy to take, evident in efficacy, be the Chinese medicine composition of a kind of desirable increase bone density, prevention of osteoporosis disease.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but protection scope of the present invention is not limited thereto:
Embodiment 1
Crude drug forms: cervus elaphus linnaeus water extract 30g, Semen Cuscutae water extract 35g, Rhizoma Drynariae water extract 40g and Herba Epimedii water extract 40g.
Prepared by cervus elaphus linnaeus water extract: cervus elaphus linnaeus is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add 8 times that water inventory is total dose, after boiling, little fire boils state, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be cervus elaphus linnaeus water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of cervus elaphus linnaeus;
Prepared by Semen Cuscutae water extract: Semen Cuscutae is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add 8 times that water inventory is total dose, after boiling, little fire boils state, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Semen Cuscutae water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of Semen Cuscutae;
Prepared by Rhizoma Drynariae water extract: Rhizoma Drynariae is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add 8 times that water inventory is total dose, after boiling, little fire boils state, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Rhizoma Drynariae water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of Rhizoma Drynariae;
Prepared by Herba Epimedii water extract: Herba Epimedii is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add 8 times that water inventory is total dose, after boiling, little fire boils state, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Herba Epimedii water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of Herba Epimedii;
Finally cervus elaphus linnaeus water extract 30g, Semen Cuscutae water extract 35g, Rhizoma Drynariae water extract 40g and Herba Epimedii water extract 40g are mixed, the concentration of water-soluble extract gross weight 5-10 times weight is in the ethanol water according to weighing scale 95%, be uniformly mixed, quantitative separating, obtains oral liquid formulations.
Embodiment 2
Crude drug forms: cervus elaphus linnaeus 30g, Semen Cuscutae 35g, Rhizoma Drynariae 40g and Herba Epimedii 40g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 3
Crude drug forms: cervus elaphus linnaeus ethanol extraction 5g, Semen Cuscutae ethanol extraction 15g, Rhizoma Drynariae ethanol extraction 45g and Herba Epimedii ethanol extraction 35g.
Prepared by cervus elaphus linnaeus ethanol extraction: adopted by cervus elaphus linnaeus 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain cervus elaphus linnaeus extract.
Prepared by Semen Cuscutae ethanol extraction: adopted by Semen Cuscutae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Semen Cuscutae extract.
Prepared by Rhizoma Drynariae ethanol extraction: adopted by Rhizoma Drynariae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Rhizoma Drynariae extract.
Prepared by Herba Epimedii ethanol extraction: adopted by Herba Epimedii 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Herba Epimedii extract.
Cervus elaphus linnaeus ethanol extraction 5g, Semen Cuscutae ethanol extraction 15g, Rhizoma Drynariae ethanol extraction 45g be dry, pulverize into fine powder respectively with Herba Epimedii ethanol extraction 35g, sieve, mixing, granulate, be pressed into tablet.
Embodiment 4
Crude drug forms: cervus elaphus linnaeus 5g, Semen Cuscutae 15g, Rhizoma Drynariae 45g and Herba Epimedii 35g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 5
Crude drug forms: cervus elaphus linnaeus extract 10g, Semen Cuscutae 10g, Rhizoma Drynariae 40g and Herba Epimedii 40g.
The preparation of cervus elaphus linnaeus extract: adopted by cervus elaphus linnaeus 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, get clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain cervus elaphus linnaeus extract.
Aforementioned cervus elaphus linnaeus extract 10g, Semen Cuscutae 10g, Rhizoma Drynariae 40g and Herba Epimedii 40g are ground into fine powder, sieve, mixing, adds the magnesium stearate of gross weight 2%, incapsulates.
Embodiment 6
Crude drug forms: cervus elaphus linnaeus 10g, Semen Cuscutae 10g, Rhizoma Drynariae 40g and Herba Epimedii 40g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 7
Crude drug forms: cervus elaphus linnaeus 15g, Semen Cuscutae extract 5g, Rhizoma Drynariae extract 35g and Herba Epimedii 45g.
Prepared by Semen Cuscutae extract: adopted by Semen Cuscutae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Semen Cuscutae extract.
Prepared by Rhizoma Drynariae extract: adopted by Rhizoma Drynariae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Rhizoma Drynariae extract.
Cervus elaphus linnaeus 15g, Semen Cuscutae extract 5g, Rhizoma Drynariae extract 35g and Herba Epimedii 45g mixing is broken into fine powder, sieves, add the magnesium stearate of gross weight 2%, incapsulate.
Embodiment 8
Crude drug forms: cervus elaphus linnaeus 15g, Semen Cuscutae 5g, Rhizoma Drynariae 35g and Herba Epimedii 45g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 9
Crude drug forms: sika deer velvet antler extract 3g, Semen Cuscutae extract 2g, Rhizoma Drynariae extract 75g and Herba Epimedii 80g.
Prepared by sika deer velvet antler extract: adopt 10% ~ 90% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time sika deer velvet antler, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain sika deer velvet antler extract.
Prepared by Semen Cuscutae extract: adopt 10% ~ 90% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time Semen Cuscutae, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Semen Cuscutae extract.
Prepared by Rhizoma Drynariae extract: adopt 10% ~ 90% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time Rhizoma Drynariae, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Rhizoma Drynariae extract.
Sika deer velvet antler extract 3g, Semen Cuscutae extract 2g, Rhizoma Drynariae extract 75g and Herba Epimedii 80g are dried and crushed into fine powder, sieve, mixing, granulate, be pressed into tablet.
Embodiment 10
Crude drug forms: sika deer velvet antler 3g, Semen Cuscutae 2g, Rhizoma Drynariae 75g and Herba Epimedii 80g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 11
Crude drug forms: sika deer velvet antler 60g, Semen Cuscutae 2g, Rhizoma Drynariae extract 4g and Herba Epimedii 80g.
Prepared by Rhizoma Drynariae extract: adopt 10% ~ 90% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time Rhizoma Drynariae, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Rhizoma Drynariae extract.
Sika deer velvet antler 60g, Semen Cuscutae 2g, Rhizoma Drynariae extract 4g and Herba Epimedii 80g mixing is broken into fine powder, sieves, add the magnesium stearate of gross weight 2%, incapsulate.
Embodiment 12
Crude drug forms: sika deer velvet antler 60g, Semen Cuscutae 2g, Rhizoma Drynariae 4g and Herba Epimedii 80g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 13
Crude drug forms: sika deer velvet antler 60g, Semen Cuscutae 65g, Rhizoma Drynariae extract 4g and Herba Epimedii extract 3g.
Prepared by Rhizoma Drynariae extract: adopt 10% ~ 90% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time Rhizoma Drynariae, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Rhizoma Drynariae extract.
Prepared by Herba Epimedii water extract: Herba Epimedii is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add 8 times that water inventory is total dose, after boiling, little fire boils state, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Herba Epimedii water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of Herba Epimedii.
Be dried and crushed into fine powder after aforementioned component being mixed, sieve, mixing, granulate, be pressed into tablet.
Embodiment 14
Raw material forms: sika deer velvet antler 60g, Semen Cuscutae 65g, Rhizoma Drynariae 4g and Herba Epimedii 3g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Have studied the impact of Chinese medicine composition of the present invention on SD osteoporosis rat below:
120 SD rats of 5 ~ 7 weeks are divided into 4 groups at random, are respectively Normal group, model control group, Chinese medicine low dose group and Chinese medicine high dose group.By the mice of model control group, Chinese medicine low dose group and Chinese medicine high dose group respectively gavage isotretinoin capsules make osteoporosis mouse model.
Afterwards the mice of Normal group is injected distilled water every day, the mice of model group injects distilled water every day, Chinese medicine low dose group injects the Chinese medicine composition (prepared by embodiment 3) of 20g/kg every day, the mice of Chinese medicine high dose group injects the Chinese medicine composition (prepared by embodiment 3) of 40g/kg every day, and the administration time of this experiment is 1 month.
After administration, detect the weight of femur of the rat of Normal group, model control group, Chinese medicine low dose group and Chinese medicine high dose group, the content of bone calcium and bone density, concrete outcome is in table 1.
Table 1 Chinese medicine composition of the present invention is on the weight of mouse femur, the content of bone calcium and the impact of bone density
As can be seen from Table 1, the mice of Normal group and the mice of model control group have larger difference in the weight of femur, the content of bone calcium and bone density, can be successfully established by perception model, from the contrast of model group and Chinese drug-treated group, adopt technical solution of the present invention Chinese medicine composition to after mice treatment, the weight of the femur of mice, the content of bone calcium and bone density obviously increase, and namely the osteoporosis of technical solution of the present invention to mice possesses certain curative effect.
Clinical observation
1) selected experimental subject is all from Yancheng hospital, and selected experimental subject all has osteoporosis, and with the symptom of lumbar and back pain.
2) method of administration and the course for the treatment of
The oral embodiment of the present invention 1 ~ 14; Contrast: Cornu Cervi Pantotrichum; Semen Cuscutae; Cornu Cervi Pantotrichum+Rhizoma Drynariae; Semen Cuscutae+Rhizoma Drynariae+Herba Epimedii (1:1:1); Cornu Cervi Pantotrichum+Semen Cuscutae+Rhizoma Drynariae (1:1:1)
The each 6g of oral liquid, every day 3 times; Each 4 of capsule, every day 3 times; The each 4.5g of tablet, every day 3 times.
Be a course for the treatment of with one month, it treats 3 courses for the treatment of.
3) criterion of osteoporosis symptoms
Cure: back is painless;
Improve: back random thoughts pain;
Invalid: back is always with pain.
Wherein, " random thoughts " refer to 1 ~ 2 time/2 days.
4) therapeutic evaluation
Table 1: prescription of the present invention is to the clinical observation of osteoporosis symptoms
| Compositions | Number of cases | Cure | Improve | Invalid | Total improvement rate |
| Embodiment 1 | 56 | 35 | 15 | 6 | 89.3％ |
| Embodiment 2 | 68 | 36 | 22 | 10 | 85.3％ |
| Embodiment 3 | 59 | 41 | 11 | 7 | 88.1％ |
| Embodiment 4 | 53 | 34 | 13 | 6 | 88.7％ |
| Embodiment 5 | 54 | 32 | 15 | 7 | 87.0％ |
| Embodiment 6 | 65 | 41 | 15 | 9 | 86.2％ |
| Embodiment 7 | 48 | 31 | 10 | 7 | 85.4％ |
| Embodiment 8 | 50 | 28 | 13 | 9 | 82.0％ |
| Embodiment 9 | 45 | 24 | 13 | 8 | 82.2％ |
| Embodiment 10 | 65 | 27 | 26 | 12 | 81.5％ |
| Embodiment 11 | 68 | 28 | 27 | 13 | 80.9％ |
| Embodiment 12 | 49 | 22 | 18 | 9 | 81.6％ |
| Embodiment 13 | 61 | 36 | 13 | 12 | 80.3％ |
| Embodiment 14 | 43 | 23 | 12 | 8 | 81.4％ |
| Cornu Cervi Pantotrichum | 60 | 20 | 15 | 25 | 58.3％ |
| Semen Cuscutae | 55 | 22 | 12 | 21 | 61.8％ |
| Cornu Cervi Pantotrichum+Rhizoma Drynariae | 68 | 27 | 17 | 24 | 64.7％ |
| Semen Cuscutae+Rhizoma Drynariae+Herba Epimedii | 72 | 31 | 20 | 21 | 70.8％ |
| Cornu Cervi Pantotrichum+Semen Cuscutae+Rhizoma Drynariae | 69 | 38 | 12 | 19 | 72.5％ |
As can be seen from Table 1, the Chinese medicine composition of technical solution of the present invention has good curative effect to the lumbar and back pain that osteoporosis causes, and the beneficial effect of this Chinese medicine composition to human body effect be single dose incomparable.
Claims (10)
1. for a Chinese medicine composition for strong bone, it is characterized in that: the effective ingredient of this Chinese medicine composition is Cornu Cervi Pantotrichum, Semen Cuscutae, Rhizoma Drynariae, Herba Epimedii, and form according to following weight percentage ratio: Cornu Cervi Pantotrichum 1-85 part, Semen Cuscutae 1-90 part, Rhizoma Drynariae 1-90 part and Herba Epimedii 1-95 part.
2. the Chinese medicine composition for strong bone according to claim 1, is characterized in that: in this Effective Component of Chinese Medicine, Cornu Cervi Pantotrichum 3-60 part, Semen Cuscutae 2-65 part, Rhizoma Drynariae 4-75 part and Herba Epimedii 3-80 part.
3. the Chinese medicine composition for strong bone according to claim 2, is characterized in that: in this Effective Component of Chinese Medicine, 5 ~ 15 parts, Cornu Cervi Pantotrichum, Semen Cuscutae 5 ~ 15 parts, Rhizoma Drynariae 35 ~ 45 parts and Herba Epimedii 35 ~ 45 parts.
4. the Chinese medicine composition for strong bone according to claim 3, is characterized in that: in this Effective Component of Chinese Medicine, 10 parts, Cornu Cervi Pantotrichum, Semen Cuscutae 10 parts, Rhizoma Drynariae 40 parts and Herba Epimedii 40 parts.
5. the Chinese medicine composition for strong bone described in any one of claim 1-4, is characterized in that: Cornu Cervi Pantotrichum, Semen Cuscutae, in Rhizoma Drynariae and Herba Epimedii at least one with the form of its extract for effective ingredient.
6. the Chinese medicine composition for strong bone according to claim 5, is characterized in that: the extract of organic solvent that Cornu Cervi Pantotrichum extract is Cornu Cervi Pantotrichum water or dissolves each other with water; The extract of organic solvent that Semen Cuscutae extract is Semen Cuscutae water or dissolves each other with water; The extract of organic solvent that Rhizoma Drynariae extract is osteomiosis moisturizing or dissolves each other with water; The extract of organic solvent that Herba Epimedii extract is Herba Epimedii water or dissolves each other with water.
7. the Chinese medicine composition for strong bone according to claim 6, is characterized in that: the described organic solvent dissolved each other with water is any one in methanol, ethanol, acetone.
8. the Chinese medicine composition for strong bone according to claim 6, is characterized in that: extracting method be decoct in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects any one or a few.
9. the Chinese medicine composition for strong bone according to any one of claim 1-5, is characterized in that: after the extract mixing of described compositions or compositions, add the acceptable adjuvant of pharmaceutics, make clinical acceptable dosage form; Described dosage form is the preparation of peroral dosage form, Tabules or capsule formulation.
10. the Chinese medicine composition for strong bone described in any one of claim 1-5 has strong skeleton in preparation, the purposes in releasing osteoporosis health medicine.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104547832A (en) * | 2015-02-09 | 2015-04-29 | 哈尔滨工业大学 | Bone-invigorating sheep soup special for astronauts and preparation method of bone-invigorating sheep soup |
| WO2021179482A1 (en) * | 2020-03-12 | 2021-09-16 | 琛蓝(美国)营养制品股份有限公司 | Traditional chinese medicine compound composition having effect of promoting bone health as well as preparation method therefor and application thereof |
| US11517602B2 (en) * | 2020-03-12 | 2022-12-06 | Chenland Nutritionals Inc. | Traditional Chinese medicine composition for improving bone health and preparation and uses thereof |
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| KR20030006736A (en) * | 2001-07-14 | 2003-01-23 | (주) 메드빌 | Composition for preventing or treating osteoporosis comprising plant extracts and method of preparing the same |
| CN1660196A (en) * | 2004-12-13 | 2005-08-31 | 武汉健民中药工程有限责任公司 | Extractive of Chinese traditional medicine prepared from epimedium and drynaria, and method for producing preparation |
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| KR20030006736A (en) * | 2001-07-14 | 2003-01-23 | (주) 메드빌 | Composition for preventing or treating osteoporosis comprising plant extracts and method of preparing the same |
| CN1660196A (en) * | 2004-12-13 | 2005-08-31 | 武汉健民中药工程有限责任公司 | Extractive of Chinese traditional medicine prepared from epimedium and drynaria, and method for producing preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104547832A (en) * | 2015-02-09 | 2015-04-29 | 哈尔滨工业大学 | Bone-invigorating sheep soup special for astronauts and preparation method of bone-invigorating sheep soup |
| WO2021179482A1 (en) * | 2020-03-12 | 2021-09-16 | 琛蓝(美国)营养制品股份有限公司 | Traditional chinese medicine compound composition having effect of promoting bone health as well as preparation method therefor and application thereof |
| US11517602B2 (en) * | 2020-03-12 | 2022-12-06 | Chenland Nutritionals Inc. | Traditional Chinese medicine composition for improving bone health and preparation and uses thereof |
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