CN101375962B - Formulation for activating blood and freeing collateral vessels and preparation method thereof - Google Patents
Formulation for activating blood and freeing collateral vessels and preparation method thereof Download PDFInfo
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- CN101375962B CN101375962B CN2008101519176A CN200810151917A CN101375962B CN 101375962 B CN101375962 B CN 101375962B CN 2008101519176 A CN2008101519176 A CN 2008101519176A CN 200810151917 A CN200810151917 A CN 200810151917A CN 101375962 B CN101375962 B CN 101375962B
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Abstract
The invention relates to a preparation with effects of promoting blood circulation and dredging meridians, and a preparation method thereof. The preparation is prepared from the following Chinese traditional medicines by weight: 80-120 parts of Semen Cassiae, 70-100 parts of Chrysanthemum morifolium flower, 70-100 parts of Concha Haliotidis, 80-110 parts of Ramulus Uncariae Cum Uncis, 70-120 parts of Salvia miltiorrhiza, 60-130 parts of Trionyx sinensis shell (processed), 70-130 parts of Concha Ostreae, 50-80 parts of Leonurus heterophyllus, 60-110 parts of Crataegus pinnatifida, 50-100 partsof Magnolia officinalis (processed), 60-90 parts of Poria cocos,75-115 parts of Raphanus sativus seed (parched), 65-115 parts of Cinnamomum cassia twig, 10-20 parts of Radix Et Rhizoma Rhei, 30-60 parts of Citrus aurantium (parched), 30-60 parts of Scutellaria baicalensis, and 30-60 parts of Achyranthes bidentata. The effective ingredients of the raw materials in the preparation are extracted by decoction, and activities thereof are remained, so as to remarkably improve the dissolution rate, promote absorption of the effective ingredients, and further improve bioavailability. In addition, thepreparation is a pure Chinese medicinal preparation with good safety and no toxic or side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly relating to a kind of is promoting blood circulation to remove obstruction in the collateral preparation of making of raw material and preparation method thereof with Chinese medicine.
Background technology
Hypertension, hyperlipidemia, high blood viscosity are the common diseases of middle-aging male, and be clinical mainly with blood pressure, blood fat, one of blood viscosity or multinomial rising, mainly shows as headache, has a dizzy spell, symptom such as backache uncomfortable in chest.Though it is many to be used for the treatment of the types of drugs of hypertension, hyperlipidemia, high blood viscosity at present clinically, but specific aim is not strong, and the toxic and side effects of some medicine is big, so take the back belongs to deficiency of YIN blood stasis blocking type hypertension, hyperlipidemia, this disease of high blood viscosity to treatment DeGrain.
Summary of the invention
In order to address the above problem, the object of the present invention is to provide a kind of treatment deficiency of YIN blood stasis blocking type hypertension, hyperlipidemia, high blood viscosity disease effect obvious, thereby with strong points, and the promoting blood circulation to remove obstruction in the collateral preparation that has no side effect.
Another object of the present invention is to provide a kind of method that is used to prepare above-mentioned promoting blood circulation to remove obstruction in the collateral preparation.
In order to achieve the above object, promoting blood circulation to remove obstruction in the collateral preparation provided by the invention is that the following medicine material of weight ratio is made by consumption mainly:
Semen Cassiae 80-120 Flos Chrysanthemis 70-100 Concha Haliotidis 70-100
Ramulus Uncariae Cum Uncis 80-110 Radix Salviae Miltiorrhizaes, 70-120 Carapax Trionycis (system) 60-130
Concha Ostreae 70-130 Herba Leonuris 50-80 Fructus Crataegis 60-110
Cortex Magnoliae Officinalis (system) 50-100 Poria, 60-90 Semen Raphanis (stir-fry) 75-115
Ramulus Cinnamomi 65-115 Radix Et Rhizoma Rhei 10-20 Fructus Aurantii (parched) 30-60
Radix Scutellariae 30-60 Radix Achyranthis Bidentataes 30-60
The preparation method of described promoting blood circulation to remove obstruction in the collateral preparation is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then Semen Cassiae, Radix Salviae Miltiorrhizae, each 1/3rd amount of Radix Et Rhizoma Rhei are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Semen Cassiae, Radix Salviae Miltiorrhizae, 14 kinds of medicine materials of Radix Et Rhizoma Rhei and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Promoting blood circulation to remove obstruction in the collateral preparation provided by the invention is that the method for employing decocting in water extraction is extracted the effective ingredient in the material medicine, and keep its activity, can make so not only that the dissolution of effective ingredient improves greatly in the medicine, and help the absorption of medicine, thereby can improve its bioavailability.In addition, medicine of the present invention is a pure Chinese medicinal preparation, thereby the patient can not produce toxic and side effects after taking for a long time, so safety is good.In addition, preparation method technology of the present invention is simple, easy to operate.
The specific embodiment
The hypertension of modern medicine, hyperlipidemia, arteriosclerosis, clinical visible dizziness, headache, dizzy, vision and hypomnesis, symptoms such as limbs fatigue.This dizzy card with traditional Chinese medical science hyperactivity of YANG due to deficiency of YIN, the resistance of the damp-phlegm stasis of blood is very similar.So side's legislation is nourishing YIN for suppressing the hyperactive YANG, suppressing the hyperactive liver to relieve the wind syndrome is held concurrently with blood circulation promoting and blood stasis dispelling.Ramulus Uncariae Cum Uncis is sweet in the side is slightly cold, the heat clearing away suppressing the hyperactive liver, and relieving spasm by subduing liver-wind is apt to having a dizzy spell for the treatment of the liver sun rising; Flos Chrysanthemi sweetness and bitterness is cold, wind and heat dispersing, YIN nourishing makes eye bright, and both can evacuate affection due to external wind and heat, but again liver nourishing the moon to put out liver-wind; The cold of Semen Cassiae sweetness and bitterness, liver heat removing and eyesight improving; Concha Haliotidis is salty to be slightly cold, suppressing the hyperactive liver to relieve the wind syndrome, liver heat removing and eyesight improving, more than four medicines be monarch drug altogether.The Radix Salviae Miltiorrhizae hardship is slightly cold, blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, nourishing blood to tranquillize the mind; Herba Leonuri is arduous to be slightly cold, blood circulation promoting and blood stasis dispelling, and inducing diuresis to remove edema, two medicines share, and the power of promoting blood circulation to remove obstruction in the collateral is stronger.Carapax Trionycis is salty flat, replenishing YIN and removing heat, hard masses softening and resolving; The salty little cold of Concha Ostreae, tonifying YIN YANG hyperactivity suppressing, tranquillizing the mind by relieving convulsion, but this two medicines nourishing YIN for suppressing the hyperactive YANG, tranquillizing the mind by relieving convulsion.More than four medicine promoting blood circulation to remove obstruction in the collateral, nourishing YIN for suppressing the hyperactive YANG is ministerial drug altogether.The sweet tepor of Crataegolic acid, promoting digestion and removing stagnation, the loose flesh of invigorating blood circulation; Semen Raphani Xin Ganping stagnates conductance; The cold of Fructus Aurantii toil, dispelling the stagnated QI reduces phlegm, the removing food stagnancy painful abdominal mass of loosing; Cortex Magnoliae Officinalis toil temperature, removing dampness intestinal stasis relieving, the circulation of qi promoting heap soil or fertilizer over and around the roots that disappears; Poria is sweet light flat, invigorating the spleen to clear away damp pathogen, mind tranquilizing and the heart calming; Ramulus Cinnamomi Xin Ganwen, promoting the flow of QI in the collateral by warming the meridian; The Radix Et Rhizoma Rhei bitter cold, stasis removing, the logical knot of removing blood stasis; The Radix Scutellariae bitter cold, heat clearing and damp drying, but more than all medicine promoting QI to circulate and dispersing the agglomeration of the pathogens, damp eliminating is reduced phlegm, and is adjuvant drug altogether.The Radix Achyranthis Bidentatae picric acid is flat, blood circulation promoting and blood stasis dispelling, and conducting blood to flow downwards, and be messenger drug.
Below in conjunction with embodiment promoting blood circulation to remove obstruction in the collateral preparation provided by the invention and preparation method thereof is elaborated.
Embodiment 1:
Promoting blood circulation to remove obstruction in the collateral preparation in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Semen Cassiae 96 Flos Chrysanthemis 74 Concha Haliotidis 96
Ramulus Uncariae Cum Uncis 96 Radix Salviae Miltiorrhizaes, 96 Carapax Trionycis (system) 96
Concha Ostreae 96 Herba Leonuris 74 Fructus Crataegis 96
Cortex Magnoliae Officinalis (system) 74 Poria, 72 Semen Raphanis (stir-fry) 96
Ramulus Cinnamomi 96 Radix Et Rhizoma Rhei 14 Fructus Aurantii (parched) 48
Radix Scutellariae 48 Radix Achyranthis Bidentataes 48
Preparation method:
(a) the said medicine raw material is carried out weighing according to proportioning, then Semen Cassiae, Radix Salviae Miltiorrhizae, each 1/3rd amount of Radix Et Rhizoma Rhei are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Semen Cassiae, Radix Salviae Miltiorrhizae, 14 kinds of medicine materials of Radix Et Rhizoma Rhei and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Embodiment 2:
Promoting blood circulation to remove obstruction in the collateral preparation in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Semen Cassiae 80 Flos Chrysanthemis 70 Concha Haliotidis 70
Ramulus Uncariae Cum Uncis 80 Radix Salviae Miltiorrhizaes, 70 Carapax Trionycis (system) 60
Concha Ostreae 70 Herba Leonuris 50 Fructus Crataegis 60
Cortex Magnoliae Officinalis (system) 50 Poria, 60 Semen Raphanis (stir-fry) 75
Ramulus Cinnamomi 65 Radix Et Rhizoma Rhei 10 Fructus Aurantii (parched) 30
Radix Scutellariae 30 Radix Achyranthis Bidentataes 30
Preparation method is with embodiment 1.
Embodiment 3:
Promoting blood circulation to remove obstruction in the collateral preparation in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Semen Cassiae 120 Flos Chrysanthemis 100 Concha Haliotidis 100
Ramulus Uncariae Cum Uncis 110 Radix Salviae Miltiorrhizaes, 120 Carapax Trionycis (system) 130
Concha Ostreae 130 Herba Leonuris 80 Fructus Crataegis 110
Cortex Magnoliae Officinalis (system) 100 Poria, 90 Semen Raphanis (stir-fry) 115
Ramulus Cinnamomi 115 Radix Et Rhizoma Rhei 20 Fructus Aurantii (parched) 60
Radix Scutellariae 60 Radix Achyranthis Bidentataes 60
Preparation method is with embodiment 1.
Promoting blood circulation to remove obstruction in the collateral preparation provided by the invention is brown to sepia; Feeble QI, lightly seasoned.In order to verify the therapeutic effect of this promoting blood circulation to remove obstruction in the collateral preparation, the patient that the inventor utilizes the capsule that belongs to oral solid formulation in the above-mentioned promoting blood circulation to remove obstruction in the collateral preparation that 207 examples are suffered from deficiency of YIN blood stasis blocking type hypertension, hyperlipidemia, high blood viscosity has carried out system's clinical observation, 3 of each medications, every day 2 times, 60 days is 1 course of treatment.After 1 course of therapy, cure (blood pressure, blood fat, blood viscosity laboratory indexes all return to normal range) 47 examples altogether, account for 22.7%; Effectively (blood pressure, blood fat, blood viscosity laboratory indexes decrease, but abnormal fully) 146 examples account for 70.5%; Invalid (blood pressure, blood fat, blood viscosity laboratory indexes do not have significant change) 14 examples account for 6.8%; Total effective rate is 93.2%.After 2 course of therapy, cure 87 examples altogether, account for 42.0%; Effective 110 examples account for 53.1%; Invalid 10 examples account for 4.8%; Total effective rate is 95.2%.
Simultaneously, the inventor analyzes therapeutic effect and the relation between the course of treatment, and analysis result sees Table 1.
Table 1: promoting blood circulation to remove obstruction in the collateral preparation for treating effect provided by the invention and the course of treatment relation table
With the data x in the above-mentioned table 1
2Method of inspection calculates, and the result is P＜0.005, can prove that thus taking promoting blood circulation to remove obstruction in the collateral preparation provided by the invention treats deficiency of YIN blood stasis blocking type hypertension, hyperlipidemia, high blood viscosity disease, and along with going deep into of treatment, cure rate, effective percentage all obviously improve.
Claims (2)
1. promoting blood circulation to remove obstruction in the collateral preparation is characterized in that: described promoting blood circulation to remove obstruction in the collateral preparation is that the following medicine material of weight ratio is made by consumption:
Semen Cassiae 80-120 Flos Chrysanthemi 70-100 Concha Haliotidis 70-100
Ramulus Uncariae Cum Uncis 80-110 Radix Salviae Miltiorrhizae 70-120 Carapax Trionycis (processed) 60-130
Concha Ostreae 70-130 Herba Leonuri 50-80 Fructus Crataegi 60-110
Sichuan Cortex Magnoliae Officinalis (processed) 50-100 Poria 60-90 Semen Raphani (parched) 75-115
Ramulus Cinnamomi 65-115 Radix Et Rhizoma Rhei 10-20 Fructus Aurantii (parched) 30-60
Radix Scutellariae 30-60 Radix Achyranthis Bidentatae 30-60.
2. the preparation method of a promoting blood circulation to remove obstruction in the collateral preparation as claimed in claim 1, it is characterized in that: the preparation method of described promoting blood circulation to remove obstruction in the collateral preparation is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then Semen Cassiae, Radix Salviae Miltiorrhizae, each 1/3rd amount of Radix Et Rhizoma Rhei are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Semen Cassiae, Radix Salviae Miltiorrhizae, 14 kinds of medicine materials of Radix Et Rhizoma Rhei and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101519176A CN101375962B (en) | 2008-09-27 | 2008-09-27 | Formulation for activating blood and freeing collateral vessels and preparation method thereof |
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| CN2008101519176A CN101375962B (en) | 2008-09-27 | 2008-09-27 | Formulation for activating blood and freeing collateral vessels and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101375962A CN101375962A (en) | 2009-03-04 |
| CN101375962B true CN101375962B (en) | 2010-12-08 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698137B (en) * | 2012-06-21 | 2013-12-11 | 王杰 | Composition with blood pressure reducing function and preparation method of same |
| CN102727617B (en) * | 2012-07-04 | 2014-04-02 | 许瑞琴 | Chinese medicinal composition for treating hypertension |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895557A (en) * | 2006-06-28 | 2007-01-17 | 陈志忠 | Chinese-medicinal herb for treating hypertension, high-blood-fat and hyperglycosemia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895557A (en) * | 2006-06-28 | 2007-01-17 | 陈志忠 | Chinese-medicinal herb for treating hypertension, high-blood-fat and hyperglycosemia |
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Effective date of registration: 20170606 Address after: 300210 Tianjin city Hexi District Liberation Road No. 447 Patentee after: Tianjin Caokaiyong Hospital of traditional Chinese Medicine Address before: Yingkou Heping District 300040 Tianjin City Road 36 No. E119 Patentee before: Cao Kaiyong |
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Granted publication date: 20101208 Termination date: 20210927 |
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