CN107773551A - A kind of processing method of the prepared slices of Chinese crude drugs - Google Patents
A kind of processing method of the prepared slices of Chinese crude drugs Download PDFInfo
- Publication number
- CN107773551A CN107773551A CN201610734911.6A CN201610734911A CN107773551A CN 107773551 A CN107773551 A CN 107773551A CN 201610734911 A CN201610734911 A CN 201610734911A CN 107773551 A CN107773551 A CN 107773551A
- Authority
- CN
- China
- Prior art keywords
- medicinal material
- less
- prepared slices
- crude drugs
- chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of processing method of the prepared slices of Chinese crude drugs, it is main to include that processing drying will be carried out according to national standard specification without the more selenium medicinal materials of sulphur, removing heavy metals embathe after being processed into coarse powder, powder is ground into by collision type pulverizer, required according to sterilizing, powder medicinal material is sterilized using radiation sterilization or ozone sterilization method, is eventually fabricated capsule medicine materical crude slice, inspection, qualified the step of the selling that can dispatch from the factory are sampled to capsule medicine materical crude slice.Chinese medicinal material is processed into powder medicinal material by the present invention, and capsule medicine materical crude slice is made, and different from traditional Chinese medicine medicine materical crude slice, capsule medicine materical crude slice is adapted to the oral of different crowd, has established the directly oral basis of the prepared slices of Chinese crude drugs.Meanwhile the present invention can remove the harmful substances such as heavy metal in Chinese medicinal material in the case where retaining the constant principle in medicine basis, substantially increase the quality of the prepared slices of Chinese crude drugs.
Description
Technical field
The invention belongs to a kind of field of traditional Chinese, and in particular to a kind of processing method of the prepared slices of Chinese crude drugs.
Background technology
The developing history of Chinese medicine is long, and the species of Chinese medicine is also very extensive, and the often use of Chinese medicine is for not
Same crowd, suits the remedy to the case, and the use that this also results in Chinese medicine is extremely complex.And the prepared slices of Chinese crude drugs are medicinal materials by traditional Chinese medical theory, warp
Cross the medicine that Processing methods are used for tcm clinical practice.Its process includes medicinal material and processed, and concocting process includes net system, profit system
And cutting.But traditional prepared slices of Chinese crude drugs manufacturing process is excessively simple, is not easy to taking for patient.Meanwhile traditional Chinese medicine adds
Work process is not directed to remove the harmful substance in Chinese medicine, and this quality for also resulting in medicinal material reduces.
The content of the invention
In order to solve above-mentioned problem, the present invention provides a kind of processing method of the prepared slices of Chinese crude drugs.
The technical scheme is that：A kind of processing method of the prepared slices of Chinese crude drugs, it is characterised in that comprise the following steps：
1）To be processed without the more selenium medicinal materials of sulphur by national standard standardization, be divided into three processes wherein processing, including net system, profit system and
Cutting；First to without the more selenium medicinal material net systems of sulphur, the substandard products in medicinal material, nonuseable part and rotten Partial Resection occurring, obtains pure
Net medicinal material；Then to without the more selenium medicinal material profit systems of sulphur, the dirt on cleaning medicinal material surface；Finally to without the more selenium medicinal material cuttings of sulphur, inciting somebody to action
Medicinal material cuts into thread, strip, sheet the latter bulk；
2）Pure water saturates are used to sticky class medicinal material, and penetration period is 0.25 hour；To mineral medicine timber-used bruisher its
Smash to pieces, and the medicinal material after smashing to pieces is 20-60mm coarse powder, dries medicinal material using far-infrared radiation dry technology afterwards, is dried
The moisture of medicinal material is less than 15% afterwards；
3）Dried medicinal material is embathed by removing heavy metals, bathing preparation is ethanol, and embathes the time for 1.5 hours；
4）Medicinal material after embathing filters by crushing：Using the method for low-temperature grinding, first by the medicinal material drying after embathing, and do
Medicinal material water content after dry is less than 15%, and medicinal material is carried out into low-temperature grinding afterwards：Medicinal material cooling or it is positioned over low temperature ring
Border, finally the medicinal material of cooling is crushed by high velocity impact formula pulverizer, wherein medicinal material temperature is less than 5 DEG C after cooling, most
In the grinding medicinal materials obtained eventually, mineral substance medicinal material diameter is less than 300um, and plant medicinal material diameter is less than 250um, animal medicinal material
Diameter is less than 350um；
5）Medicinal material sterilizes：Using radiation sterilization or ozone sterilization method, powdered medicinal material is sterilized, sterilization time 2-
5 hours；
6）Capsule is made by GMP specifications in above-mentioned powder medicinal material, and capsule diameter cannot be greater than 0.8mm, length is less than 20mm,
Medicinal material content range is between 0.5-0.8g.
7）Inspection is sampled to manufactured capsule medicinal material, can dispatch from the factory sale after the assay was approved.
Preferably, the profit system described in step 1, medicinal material is soaked 0.5 hour using pure water, rinsed repeatedly with press water afterwards
Medicinal material surface more than four times, wherein press water are a kind of pure water and hydraulic pressure 5-10MPa.
Preferably, the cutting described in step 1, obtain thread medicinal material diameter and be less than or equal to 8mm, strip medicinal material length is less than etc.
In 10mm, the thickness of sheet medicinal material is less than or equal to 5mm, and the volume of block medicinal material is less than or equal to 1000mm^3.
Preferably, the far-infrared radiation dry technology described in step 2, the drying temperature of its non-volatile class medicinal material must not surpass
80 DEG C are crossed, the drying temperature of volatilization class medicinal material must not exceed 50 DEG C, and far-infrared radiation dry technology can also change hot blast into
Medicinal material is dried for formula drying machine or microwave drying technology.
Preferably, the cooling crush process described in step 4 can also use dry medicinal material to be mixed with dry ice or liquefaction nitrogen
Close, mixture is crushed by high velocity impact formula pulverizer, its Chinese medicine and dry ice or liquefaction nitrogen are with mass ratio 1:
0.3 to 1:0.5 mixed proportion uniformly mixes, and the medicinal material after crushing removes dry ice or liquefaction nitrogen by temperature-rise period；
Preferably, the sterilizing described in step 5, total number of bacteria contained by every gram of medicinal material is less than 800 after sterilizing, and wherein saccharomycete sum is small
It is less than 30, agaric in 100, mould sum and total number of molds is less than 50.
Compared with prior art, it is an advantage of the invention that：The present invention has the prepared slices of Chinese crude drugs, does not decoct, do not destroy, retaining
The original property of medicine of Chinese medicine, with modern pharmaceutical technology is combined the characteristics of, Chinese medicinal material is processed into powder medicinal material, capsule drink is made
Piece, different from traditional Chinese medicine medicine materical crude slice, capsule medicine materical crude slice is adapted to the oral of different crowd, has established the directly oral base of the prepared slices of Chinese crude drugs
Plinth.Meanwhile the present invention can be in the case where retaining the constant principle in medicine basis, the nuisance such as heavy metal in removal Chinese medicinal material
Matter, substantially increase the quality of the prepared slices of Chinese crude drugs.
Brief description of the drawings
Fig. 1 is the flow process chart of the present invention.
Embodiment
The present invention is described in further detail with embodiment below in conjunction with the accompanying drawings：
As shown in figure 1, a kind of processing method of prepared slices of Chinese crude drugs of the present invention mainly includes to mark according to country without the more selenium medicinal materials of sulphur
Quasi- specification carries out processing drying, and powder is ground into by collision type pulverizer, is required according to sterilizing, using radiation sterilization or
Ozone sterilization method sterilizes to powder medicinal material, is eventually fabricated capsule medicine materical crude slice, inspection is sampled to capsule medicine materical crude slice, qualified to dispatch from the factory
The step of sale.Specifically procedure of processing is：
1）Medicinal material is processed by national standard standardization, is divided into three processes wherein processing, including net system, profit system and cutting；It is first
First to medicinal material net system, the substandard products in medicinal material, nonuseable part and rotten Partial Resection occurs, obtains pure medicinal material；Then it is right
Medicinal material profit system, the dirt on cleaning medicinal material surface, and moisten process processed and use pure water immersion medicinal material 0.5 hour, press water is used afterwards
Medicinal material surface is rinsed repeatedly more than four times, wherein press water is a kind of pure water and hydraulic pressure 5-10MPa；Finally to medicinal material cutting,
Medicinal material is cut into thread, strip, sheet the latter bulk, wherein thread medicinal material diameter is less than or equal to 8mm, strip medicinal material length is small
It is less than or equal to 5mm in the thickness equal to 10mm, sheet medicinal material, the volume of block medicinal material is less than or equal to 1000mm^3.
2）Pure water saturates are used to sticky class medicinal material, and penetration period is 0.25 hour；Mineral medicine timber-used is smashed to pieces
It is smashed to pieces machine, and the medicinal material after smashing to pieces is 20-60mm coarse powder.Medicinal material is dried using far-infrared radiation dry technology afterwards,
The drying temperature of its non-volatile class medicinal material must not exceed 80 DEG C, and the drying temperature of volatilization class medicinal material must not exceed 50 DEG C, and remote red
UV radiation dry technology can also change heated air drier into or medicinal material is dried microwave drying technology, medicine after drying
The moisture requirement of material is less than 15%；
3）Dried medicinal material is embathed by removing heavy metals, bathing preparation is ethanol, and embathes the time for 1.5 hours；
4）Medicinal material after embathing filters by crushing：Using the method for low-temperature grinding, first by the medicinal material drying after embathing, and do
Medicinal material water content after dry is less than 15%, and medicinal material is carried out into low-temperature grinding afterwards：Medicinal material cooling or it is positioned over low temperature ring
Border, finally the medicinal material of cooling is crushed by high velocity impact formula pulverizer, wherein medicinal material temperature is less than 5 DEG C after cooling, most
In the grinding medicinal materials obtained eventually, mineral substance medicinal material diameter is less than 300um, and plant medicinal material diameter is less than 250um, animal medicinal material
Diameter is less than 350um；
Described cooling crush process can also use dry medicinal material to be mixed with dry ice or liquefaction nitrogen, and mixture is passed through into height
Fast collision type pulverizer is crushed, and its Chinese medicine and dry ice or liquefaction nitrogen are with mass ratio 1:0.3 to 1:0.5 mixing ratio
Example uniformly mixing, the medicinal material after crushing remove dry ice or liquefaction nitrogen by temperature-rise period；
5）Medicinal material sterilizes：Using radiation sterilization or ozone sterilization method, powdered medicinal material is sterilized, sterilization time 2-
5 hours；And sterilize after total number of bacteria contained by every gram of medicinal material be less than 800, wherein saccharomycete sum be less than 100, it is mould sum be less than 30,
Agaric and total number of molds are less than 50.
6）Capsule is made by GMP specifications in above-mentioned powder medicinal material, and capsule diameter cannot be greater than 0.8mm, length is less than
20mm, medicinal material content range is between 0.5-0.8g.
7）Inspection is sampled to manufactured capsule medicinal material, can dispatch from the factory sale after the assay was approved.
Above by the introduction to the embodiment, general principle and the design of the present invention are elaborated.But the present invention never limits
In embodiment described above, every similar changes and improvements made based on technical scheme, these changes and
Improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by appended claims and its equivalent
Thing defines.
Claims (5)
1. a kind of processing method of the prepared slices of Chinese crude drugs, it is characterised in that comprise the following steps：
1）To be processed without the more selenium medicinal materials of sulphur by national standard standardization, be divided into three processes wherein processing, including net system, profit system and
Cutting；First to without the more selenium medicinal material net systems of sulphur, the substandard products in medicinal material, nonuseable part and rotten Partial Resection occurring, obtains pure
Net medicinal material；Then to without the more selenium medicinal material profit systems of sulphur, the dirt on cleaning medicinal material surface；Finally to without the more selenium medicinal material cuttings of sulphur, inciting somebody to action
Medicinal material cuts into thread, strip, sheet the latter bulk；
2）Pure water saturates are used to sticky class medicinal material, and penetration period is 0.25 hour；To mineral medicine timber-used bruisher its
Smash to pieces, and the medicinal material after smashing to pieces is 20-60mm coarse powder, dries medicinal material using far-infrared radiation dry technology afterwards, is dried
The moisture of medicinal material is less than 15% afterwards；
3）Dried medicinal material is embathed by removing heavy metals, bathing preparation is ethanol, and embathes the time for 1.5 hours；
4）Medicinal material after embathing filters by crushing：Using the method for low-temperature grinding, first by the medicinal material drying after embathing, and do
Medicinal material water content after dry is less than 15%, and medicinal material is carried out into low-temperature grinding afterwards：Medicinal material cooling or it is positioned over low temperature ring
Border, finally the medicinal material of cooling is crushed by high velocity impact formula pulverizer, wherein medicinal material temperature is less than 5 DEG C after cooling, most
In the grinding medicinal materials obtained eventually, mineral substance medicinal material diameter is less than 300um, and plant medicinal material diameter is less than 250um, animal medicinal material
Diameter is less than 350um；
Described cooling crush process can also use dry medicinal material to be mixed with dry ice or liquefaction nitrogen, and mixture is passed through into height
Fast collision type pulverizer is crushed, and its Chinese medicine and dry ice or liquefaction nitrogen are with mass ratio 1:0.3 to 1:0.5 mixing ratio
Example uniformly mixing, the medicinal material after crushing remove dry ice or liquefaction nitrogen by temperature-rise period；
Medicinal material sterilizes：Using radiation sterilization or ozone sterilization method, powdered medicinal material is sterilized, sterilization time 2-5
Hour；
Capsule is made by GMP specifications in above-mentioned powder medicinal material, and capsule diameter cannot be greater than 0.8mm, length is less than 20mm, medicine
Material content range is between 0.5-0.8g；
Inspection is sampled to manufactured capsule medicinal material, can dispatch from the factory sale after the assay was approved.
A kind of 2. processing method of prepared slices of Chinese crude drugs according to claim 1, it is characterised in that：Profit system described in step 1, adopt
Medicinal material is soaked with pure water 0.5 hour, rinses medicinal material surface repeatedly with press water afterwards more than four times, and wherein press water is one kind
Pure water and hydraulic pressure 5-10MPa.
A kind of 3. processing method of prepared slices of Chinese crude drugs according to claim 1, it is characterised in that：Cutting described in step 1, is obtained
It is less than or equal to 8mm to thread medicinal material diameter, strip medicinal material length is less than or equal to 10mm, and the thickness of sheet medicinal material is less than or equal to 5mm,
The volume of block medicinal material is less than or equal to 1000mm^3.
A kind of 4. processing method of prepared slices of Chinese crude drugs according to claim 1, it is characterised in that；Far infrared described in step 2
Beta radiation dry technology, the drying temperature of its non-volatile class medicinal material must not exceed 80 DEG C, and the drying temperature of volatilization class medicinal material must not
More than 50 DEG C, and far-infrared radiation dry technology can also change heated air drier into or microwave drying technology enters to medicinal material
Row drying.
A kind of 5. processing method of prepared slices of Chinese crude drugs according to claim 1, it is characterised in that：Sterilizing described in step 5, goes out
Total number of bacteria contained by every gram of medicinal material is less than 800 after bacterium, and wherein saccharomycete sum is less than 100, mould sum and is less than 30, agaric and mould
Sum is less than 50.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610734911.6A CN107773551A (en) | 2016-08-28 | 2016-08-28 | A kind of processing method of the prepared slices of Chinese crude drugs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610734911.6A CN107773551A (en) | 2016-08-28 | 2016-08-28 | A kind of processing method of the prepared slices of Chinese crude drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107773551A true CN107773551A (en) | 2018-03-09 |
Family
ID=61439906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610734911.6A Pending CN107773551A (en) | 2016-08-28 | 2016-08-28 | A kind of processing method of the prepared slices of Chinese crude drugs |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107773551A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108338925A (en) * | 2018-04-11 | 2018-07-31 | 亳州市天济药业有限公司 | A kind of direct oral medicinal slice |
| CN108379299A (en) * | 2018-05-29 | 2018-08-10 | 张掖市金盛中药饮片有限公司 | A kind of processing method of the prepared slices of Chinese crude drugs |
-
2016
- 2016-08-28 CN CN201610734911.6A patent/CN107773551A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108338925A (en) * | 2018-04-11 | 2018-07-31 | 亳州市天济药业有限公司 | A kind of direct oral medicinal slice |
| CN108379299A (en) * | 2018-05-29 | 2018-08-10 | 张掖市金盛中药饮片有限公司 | A kind of processing method of the prepared slices of Chinese crude drugs |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101327016B (en) | Ultramicro ginger powder and method for producing the same | |
| CN103271949B (en) | A kind of directly oral medicinal slice production technology | |
| CA2061773A1 (en) | Enriched nutritious food product comprising powder of ginseng and method for producing poweder of ginseng | |
| CN103948668A (en) | Preparation method of radix tetrastigme powder | |
| CN105639659B (en) | Fiber food and preparation method thereof | |
| CN101711811A (en) | Method for preparing Chaenomeles speciosa Nakai buccal tablet | |
| CN107773551A (en) | A kind of processing method of the prepared slices of Chinese crude drugs | |
| CN102416029B (en) | Ginseng submicron powder and preparation method and preparation thereof | |
| CN106138882A (en) | The preparation method of breaking cellular wall decoction pieces | |
| CN105412043A (en) | Processing method for sulphur-free selenium-rich traditional Chinese medicine decoction pieces | |
| CN107789333A (en) | A kind of prepared slices of Chinese crude drugs processing method of drug residue free | |
| CN107029265A (en) | A kind of sterilization disinfection process of Chinese medicinal powder and the method for preparing the prepared slices of Chinese crude drugs | |
| KR101838587B1 (en) | Manufacture device and method of red pepper | |
| CN106265870A (en) | The preparation method of Radix Astragali breaking cellular wall decoction pieces | |
| CN106074678A (en) | The preparation method of Radix Glycyrrhizae breaking cellular wall decoction pieces | |
| US20130280291A1 (en) | Mineral Pitch Resin manufactured under a safe and low temperature procedure. | |
| KR101859353B1 (en) | Red pepper sterilization system | |
| Shukla et al. | A textbook of plant ecology including ethnobotany and soil science | |
| CN106880737A (en) | A kind of preparation method of taipei fritillary bulb ultra micro freeze-dried powder | |
| CN106109508A (en) | The preparation method of ganoderma lucidum wall-broken decoction pieces | |
| CN106721857A (en) | A kind of small rattan of falling an ancient unit of weight medicine materical crude slice and preparation method thereof | |
| CN107753525A (en) | The preparation method of the prepared slices of Chinese crude drugs rich in selenium | |
| CN109528888A (en) | A kind of arisaema cum bile purification medicine materical crude slice and preparation method thereof | |
| CN108186355A (en) | A kind of Full-automatic medicine processing unit (plant) | |
| CN104095885A (en) | Preparation process for high-activity stone-like omphalia directly and orally taken |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180309 |