CN106138882A - The preparation method of breaking cellular wall decoction pieces - Google Patents
The preparation method of breaking cellular wall decoction pieces Download PDFInfo
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- CN106138882A CN106138882A CN201610643227.7A CN201610643227A CN106138882A CN 106138882 A CN106138882 A CN 106138882A CN 201610643227 A CN201610643227 A CN 201610643227A CN 106138882 A CN106138882 A CN 106138882A
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- decoction pieces
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- cellular wall
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
Abstract
The present invention provides the preparation method of a kind of breaking cellular wall decoction pieces, by use medical material through picking cleanings/process of preparing Chinese medicine, medicinal material drying, crush, the pulverizer pulverizing of 100 mesh sieves, batch (-type) sterilization, breaking cellular wall, soft material processed, granulation, particle drying prepare breaking cellular wall decoction pieces, the particle type of the decoction pieces of preparation is preferable, elasticity is moderate, and the granule prepared is easier to be dried, granule leaches comparatively fast, it is easily dispersed when user is taken, batch (-type) sterilization makes decoction pieces meet the requirement of microbial limit, solves breaking cellular wall decoction pieces in the market and leaches the difficult and difficult problem up to standard of microbial limit.
Description
Technical field
The present invention relates to Chinese medicine processing technology field, particularly belong to the preparation method of a kind of breaking cellular wall decoction pieces.
Background technology
Superfine communication technique is the new technique developed rapidly in recent years.Effective ingredient in Chinese crude drug is distributed in mostly
Intracellular, conventional decoction pieces can only make part effective ingredient discharge when decocting, utilization rate of active components 10-30%；And use
Wall breaking pulverization technology, as being crushed to about 300 mesh by the prepared slices of Chinese crude drugs, cell-wall breaking ratio is up to 86.7%, improves in medical material
The dissolution of effective ingredient, is greatly enhanced its drug effect, and utilization rate of active components, more than 90%, reaches to reduce medical material usage amount and guarantor
Protecting herb resource, the quality that the most also can improve medicine increases drug effect.
CN200610122171.7 discloses the processing method of a kind of traditional Chinese herbs broken wall powder, and the step of its processing is: (1) medical material
Concoct: it includes selection, section, dried clean medical material；(2) pulverize: with above-mentioned clean medical material, with the omnipotent powder of 100 mesh sieves
Broken machine is pulverized, and wall breaking pulverization obtains the 60 above coarse powder of mesh；(3) wall breaking pulverization: by coarse powder flour obtained as above, through wall cell disruption powder powder
It is broken to more than 300 mesh, obtains superfine powder；(4) pelletize: take superfine powder obtained as above, put in flute profile mixing and blending machine, use water
Or ethanol makes soft material, pelletizing through the oscillating granulator of 30 mesh sieves, the wet granular prepared is put in heated-air circulation oven and is dried；
(5) granulate, screening: with upper strata 40 mesh, above-mentioned granulation granulate is sieved 1-3 time, makes 40 by the vibration pelletizing machine of lower floor 80 mesh sieve
Granule between mesh-80 mesh；(6) subpackage and packaging: take qualified sub-micron-powder, subpackage and outer package and obtain finished product.
According to current technique, prepared breaking cellular wall decoction pieces not only fastens, and granule is less, in actual use
It is difficult to leach, is unfavorable for the Fast Stripping of active ingredient；Medical material only selection, section, uncomfortable to the medical material needing special processing
With；Whether meet biological limit for entering the coarse powder of clean area processing method is not provided.
Summary of the invention
For the deficiencies in the prior art, the present invention provides the preparation method of a kind of breaking cellular wall decoction pieces, breaking cellular wall prepared by the method
Decoction pieces particle type is preferable, degree of tightness appropriateness, is easier to be dried, and granule leaches soon, active ingredient dissolution soon, products obtained therefrom micro-
Biological limit meets the requirements, and can guarantee that drug safety and effectively, and the time using breaking cellular wall decoction pieces prepared by the method is short, and technique becomes
This is low.
For solving above-mentioned technical problem, the present invention provides following technical scheme:
The preparation method of a kind of breaking cellular wall decoction pieces, has following steps:
(1) medical material processes: medical material is through picking cleanings/processs of preparing Chinese medicine, medicinal material drying, crushing, after the pulverizing of the pulverizer of 100 mesh sieves
Prepare the medicinal material coarse powder of 80～120 mesh；
(2) batch (-type) sterilization: the medicinal material coarse powder after step (1) being processed carries out-the hypopus that sterilizes in climatic chamber
The process grow-again sterilized, until obtaining meeting the medicinal material coarse powder directly taking decoction pieces microbial limit；
(3) breaking cellular wall: the medicinal material coarse powder after sterilization is ground into superfine powder；
(4) soft material processed: the superfine powder that breaking cellular wall prepares is placed in blender, makes soft with the ethanol of water or variable concentrations
Material；
(5) pelletize: soft material is made granule；
(6) breaking cellular wall decoction pieces will be prepared after particle drying.
What in described step (2), batch (-type) sterilized concretely comprises the following steps: (A) sterilizes: the medicinal material coarse powder after step (1) being processed
It is placed in climatic chamber and keeps drying sterilizing a period of time under uniform temperature；(B) hypopus growth: by medicinal material coarse powder in perseverance
In constant temperature and humidity case temperature be 20～30 DEG C, relative humidity 70～80% environment in maintain 8～24 hours, then by constant temperature and humidity
The temperature of case be adjusted to 33～40 DEG C, relative humidity be adjusted to 83～92% maintain 8～24 hours；(C) sterilization again: further
Medicinal material coarse powder is placed in climatic chamber drying sterilizing a period of time at a certain temperature by ground；In conventional sense medicinal material coarse powder
Microorganism situation, prepare meet the medicinal material coarse powder directly taking decoction pieces microbial limit；Described uniform temperature is 50～80 DEG C；
Described a period of time is 0.5～8 hour；The thickness that described medicinal material coarse powder is placed in climatic chamber is 5mm～30mm.
Further, after in described step (2), batch (-type) has sterilized, the microbial limit in conventional sense medicinal material coarse powder
When not meeting the situation directly taking microbial limit, repetition (B) hypopus growth and (C) sterilization process 0～4 times；Until system
The medicinal material coarse powder directly taking decoction pieces microbial limit must be met.
Further, in described step (2) batch (-type) sterilization concretely comprise the following steps: (A) sterilize: in climatic chamber protect
Hold drying sterilizing 0.5～4h；(B) hypopus growth: medicinal material coarse powder temperature in climatic chamber is 20～30 DEG C, relative humidity
70～80% environment in maintain 12～15 hours；Then the temperature of climatic chamber is adjusted to 33～40 DEG C, relative humidity
83～92% environment in maintain 12～15 hours；(C) sterilization again: keep drying sterilizing 0.5～4h at climatic chamber.
Described step (1) Chinese crude drug be dried refer to medicinal material drying to water content below 10%；Described step (1) crushes
Refer to the medical material mechanical crusher of the screen cloth of 10 mesh is broken into the little granule about 10 mesh.
Described step (5) is pelletized method particularly includes: the granulator system of soft material 14～24 mesh sieves that will make
Grain, adding superfine powder while adding soft material in granulator, completing until preparing granule；Described granulator is 14～24 mesh sieves
Oscillating granulator or squash type granulator.
Further, in the concrete grammar pelletized in described step (5), the ratio of soft material and superfine powder is 3～6:0.5
～1.In described step (6), particle drying is carried out in heated-air circulation oven, design temperature 50～80 DEG C, is dried to moisture
Less than or equal to 7%.
In described step (6), granule completes after drying, with upper strata 10 mesh, the concussion pelletizing machine granulate screening of bottom 24 mesh sieve
1～3 time, make granule between 10～24 mesh.
Breaking cellular wall in described step (3) method particularly includes: at room temperature and relative humidity in the environment of 30～70%, passes through
The medicinal material coarse powder of batch (-type) sterilization obtains superfine powder through wall breaking pulverization, and control operating pressure is 0.5～0.8MPa, and grader turns
Speed is 20～40r/s, more than wall breaking pulverization to 300 mesh；Described room temperature refers to 18～26 DEG C.
In described step (4), blender is trough type mixing machine or wet mixing pelletizer, and the ethanol of described variable concentrations is
The concentration of finger ethanol is 30%～99%.
A kind of preparation method of breaking cellular wall decoction pieces, by use medical material through picking cleanings/process of preparing Chinese medicine, medicinal material drying, crush,
The pulverizer pulverizing of 100 mesh sieves, batch (-type) sterilization, breaking cellular wall, soft material processed, granulation, particle drying prepare breaking cellular wall decoction pieces.
The screening that the present invention uses the screen cloth clearly pelletized to carry out mesh number makes granularity moderate；Limit is used in pelletization
Adding soft material limit and add the method granulation of breaking cellular wall dry powder, the particle type of gained is preferable, and elasticity is moderate, and the granule prepared is easier to
Being dried, granule leaches comparatively fast.
The sterilization process repeatable operation of medicinal material coarse powder can strengthen bactericidal effect, and cycle-index is the first shadow of sterilization process
The factor of sound, circulates the level that substantially can reach to meet the microbial limit directly taking decoction pieces 2 times, the concrete difference regarding medical material
Take different number of times.The high temperature that traditional xeothermic and wet heat sterilization is both needed to more than 80 degrees Celsius processes, and becomes material
Divide and there is certain destruction, especially inapplicable to the medical material containing heat-sensitive ingredients.The present invention uses the side that batch (-type) sterilizes
Method, the temperature of sterilization process is at 50～80 degrees Celsius, in the environment of keeping being dried, several without destroying to the composition of medical material, Er Qiejing
Cross and kill brood body-hypopus and grow-kill the process of brood body, in the environment being grown in high humidity of hypopus, treat that hypopus grows
After becoming brood body, killing, killing action is obvious, the preparation of follow-up breaking cellular wall decoction pieces, meets and directly takes the micro-of decoction pieces
The requirement of biological limit.
Beneficial effects of the present invention:
The present invention provides the preparation method of a kind of breaking cellular wall decoction pieces, and by using medical material through picking cleaning/process of preparing Chinese medicine, medical material is done
Dry, broken, the pulverizer pulverizing of 100 mesh sieves, batch (-type) sterilization, breaking cellular wall, soft material processed, granulation, particle drying prepare breaking cellular wall decoction pieces,
The particle type of the decoction pieces of preparation is preferable, and elasticity is moderate, and the granule prepared is easier to be dried, and granule leaches comparatively fast, makes
Being easily dispersed when user takes, batch (-type) sterilization completes within one device so that decoction pieces meets the requirement of microbial limit, solves
Breaking cellular wall decoction pieces leaches the difficult and difficult problem up to standard of microbial limit the most in the market.
By killing the brood body of antibacterial in medicinal material coarse powder at a certain temperature, then under conditions of room temperature high humidity, allow not
Dormancy body grows up to bacterial propagule, then through killing the brood body of the antibacterial in medicinal material coarse powder at a certain temperature, the most repeatedly 0～
4 times, thus the purpose that reaches to sterilize the most thoroughly；Sterilization process can not only ensure with the breaking cellular wall being prepared by the method for the present invention
Decoction pieces meets the microbial limit requirement directly taking decoction pieces, and is able to ensure that drug safety and the drug effect of breaking cellular wall decoction pieces.System
The sterilization temperature of standby medicinal material coarse powder is 50～80 degrees Celsius, several without impact on the content of medical material, so that it is guaranteed that drug effect and sterilization；
Do not have the situation of the oxidized degeneration of medical material；The time of method is short, consumes energy low.It addition, the present invention uses climatic chamber, have
Imitate ensure that the growing environment of hypopus in medicinal material coarse powder, can effectively prevent owing to medicinal material coarse powder sterilizes at batch (-type) simultaneously
Shi Yidong and occur foreign body, dust enter medicinal material coarse powder situation, effectively prevent secondary pollution, it can be ensured that breaking cellular wall decoction pieces
Drug safety and drug effect.Adding the method granulation of superfine powder by using limit to add soft material limit, the particle type of gained is preferable, degree of tightness
Spending moderate, and the granule prepared is easier to be dried, granule leaches comparatively fast.The method that the present invention provides is added super in pelletization
Fine powder body, prepared granule elasticity is moderate, the later stage is dried, granulate strong, be easily dispersed when user is taken, solve
Breaking cellular wall decoction pieces leaches the difficult and difficult problem up to standard of microbial limit in the market.
The preparation method that the present invention provides is simple, easily operates, low cost, is suitable for commercial Application.
Detailed description of the invention
With specific embodiment, the present invention is further illustrated below, but the present invention is not limited by following embodiment.
Embodiment 1
Semen Coicis breaking cellular wall decoction pieces
1) medical material process: by Semen Coicis medical material through pick cleaning/process of preparing Chinese medicine, medicinal material drying to medical material water content 10% with
Under, the medical material mechanical crusher of the screen cloth of 10 mesh is broken into the little granule about 10 mesh；The pulverizer of further 100 mesh sieves
Pulverize the medicinal material coarse powder preparing 80～120 mesh；
2) batch (-type) sterilization: Semen Coicis coarse powder is put in climatic chamber, places thickness and is about 10mm, and arranging temperature is 65
DEG C (actual temperature is 60～70 DEG C), keeps drying sterilizing 8h；Medicinal material coarse powder after process is 25 DEG C, relative humidity in temperature
75% maintains 12 hours；Then the temperature of climatic chamber is adjusted to 35 DEG C, relative humidity 88% maintain 24 hours；Change sets
Putting temperature is 75 DEG C (actual temperature is 70～80 DEG C), keeps drying sterilizing 4h；Microorganism feelings in conventional sense medicinal material coarse powder
Condition, must meet the Semen Coicis coarse powder directly taking decoction pieces microbial limit requirement；
3) breaking cellular wall: by particle diameter the medicinal material coarse powder of 100～120 mesh at room temperature and relative humidity in the environment of 30%, warp
Wall breaking pulverization, controls operating pressure and more than 20r/s, wall breaking pulverization to 300 mesh, obtains ultra-fine at 0.7MPa, grader rotating speed
Powder body (90% powder size is less than 45 microns)；
4) soft material processed: be placed in trough type mixing machine by prepared wall cell disruption powder, adds appropriate 30～40% ethanol, makes soft
Material；
5) pelletize: by step 4) the wall cell disruption powder soft material that makes puts in oscillating granulator forward direction screen cloth and spills a small amount of micropowder
Body, pelletizes with the screen cloth of 16 mesh, and during granulation, limit adds step 4) the wall cell disruption powder soft material that makes time limit add step 3) heart of a lotus seed prepared
Semen Coicis superfine powder, soft material is 3:1 with the ratio of superfine powder；
6) it is placed in 70 DEG C～80 DEG C of baking ovens is dried taking qualified breaking cellular wall decoction pieces granule, be dried to moisture and be less than or equal to
7%, dried granule upper strata 16 mesh, the concussion pelletizing machine granulate of bottom 20 mesh sieve sieves 2 times, and subpackage i.e. obtains Semen Coicis and breaks
Wall decoction pieces.
Embodiment 2
Semen Coicis breaking cellular wall decoction pieces
1) medical material processes: by Semen Coicis medical material through picking the water content cleaned/concoct, be dried to medical material below 10%,
The medical material mechanical crusher of the screen cloth of 10 mesh is broken into the little granule about 10 mesh；The pulverizer powder of further 100 mesh sieves
The broken medicinal material coarse powder preparing 80～120 mesh；
2) batch (-type) sterilization: Semen Coicis coarse powder is put in climatic chamber, places thickness and is about 5mm, and arranging temperature is 70
DEG C (actual temperature is 65～75 DEG C), keeps drying sterilizing 4h；Medicinal material coarse powder after process is 20 DEG C, relative humidity in temperature
70% maintains 15 hours；Then the temperature of climatic chamber is adjusted to 33 DEG C, relative humidity 83% maintain 8 hours；Change sets
Putting temperature is 65 DEG C (actual temperature is 60～70 DEG C), keeps drying sterilizing 6h；Repeat hypopus grow-again to go out bacterial reproduction
Body step 1 time, the microorganism situation in conventional sense medicinal material coarse powder；The heart of a lotus seed directly taking decoction pieces microbial limit requirement must be met
Semen Coicis coarse powder；
3) breaking cellular wall: by particle diameter the medicinal material coarse powder of 100～120 mesh at room temperature and relative humidity in the environment of 50%, warp
Wall breaking pulverization, controls operating pressure and more than 40r/s, wall breaking pulverization to 300 mesh, obtains ultra-fine at 0.5MPa, grader rotating speed
Powder body (90% powder size is less than 45 microns)；
4) soft material processed: be placed in trough type mixing machine by prepared wall cell disruption powder, adds appropriate 50～60% ethanol, makes soft
Material；
5) pelletize: by step 4) the wall cell disruption powder soft material that makes puts in oscillating granulator forward direction screen cloth and spills a small amount of micropowder
Body, pelletizes with the screen cloth of 20 mesh, and during granulation, limit adds step 4) the wall cell disruption powder soft material that makes time limit add step 3) heart of a lotus seed prepared
Semen Coicis superfine powder, soft material is 3:0.5 with the ratio of superfine powder；
6) it is placed in 60 DEG C～70 DEG C of baking ovens is dried taking qualified breaking cellular wall decoction pieces granule, dried granule upper strata 10
Mesh, the concussion pelletizing machine granulate of bottom 24 mesh sieve sieves 1 time, and subpackage i.e. obtains Semen Coicis breaking cellular wall decoction pieces.
Embodiment 3
Cortex Cinnamomi breaking cellular wall decoction pieces
1) medical material processes: by Cortex Cinnamomi medical material through picking the water content cleaned/concoct, be dried to medical material below 10%, will
The medical material mechanical crusher of the screen cloth of 10 mesh is broken into the little granule about 10 mesh；The pulverizer of further 100 mesh sieves is pulverized
Prepare the medicinal material coarse powder of 80～120 mesh；
2) batch (-type) sterilization: Cortex Cinnamomi coarse powder is put in climatic chamber, places thickness and is about 30mm, and arranging temperature is 75 DEG C
(actual temperature is 70～80 DEG C), keeps drying sterilizing 4h；Medicinal material coarse powder after process is 25 DEG C, relative humidity 75% in temperature
Maintain 24 hours；Then the temperature of climatic chamber is adjusted to 40 DEG C, relative humidity 80% maintain 12 hours；By medicinal material coarse powder
In climatic chamber, placement thickness is 10mm, and arranging temperature is 80 DEG C (actual temperature is 75～85 DEG C), keeps drying sterilizing
0.5h；Repeat step 4 time, the microorganism situation in conventional sense medicinal material coarse powder；Must meet and directly take decoction pieces microbial limit
The Cortex Cinnamomi coarse powder required；
3) breaking cellular wall: by particle diameter the medicinal material coarse powder of 100～120 mesh at room temperature and relative humidity in the environment of 60%, warp
Wall breaking pulverization, controls operating pressure and more than 30r/s, wall breaking pulverization to 300 mesh, obtains ultra-fine at 0.6MPa, grader rotating speed
Powder body (90% powder size is less than 45 microns)；
4) soft material processed: be placed in trough type mixing machine by prepared wall cell disruption powder, adds appropriate 60～70% ethanol, makes soft
Material；
5) pelletize: by step 4) the wall cell disruption powder soft material that makes puts in oscillating granulator forward direction screen cloth and spills a small amount of micropowder
Body, pelletizes with the screen cloth of 20 mesh, and during granulation, limit adds step 4) the wall cell disruption powder soft material that makes time limit add step 3) meat prepared
Osmanthus superfine powder, soft material is 6:1 with the ratio of superfine powder；
6) it is placed in 50 DEG C～60 DEG C of baking ovens is dried taking qualified breaking cellular wall decoction pieces granule, dried granule upper strata 10
Mesh, the concussion pelletizing machine granulate of bottom 24 mesh sieve sieves 3 times, and subpackage i.e. obtains Cortex Cinnamomi breaking cellular wall decoction pieces.
Embodiment 4
Cortex Cinnamomi breaking cellular wall decoction pieces
1) medical material processes: by Cortex Cinnamomi medical material through picking the water content cleaned/concoct, be dried to medical material below 10%, will
The medical material mechanical crusher of the screen cloth of 10 mesh is broken into the little granule about 10 mesh；The pulverizer of further 100 mesh sieves is pulverized
Prepare the medicinal material coarse powder of 100～120 mesh；
2) batch (-type) sterilization: Cortex Cinnamomi coarse powder is put in climatic chamber, often dish placement thickness is about 25mm, and arranging temperature is
55 DEG C (actual temperature is 50～60 DEG C), keeps drying sterilizing 0.5h；Be adjusted to 30 DEG C, relative humidity 80% maintain 8
Hour, be adjusted to 37 DEG C, relative humidity 92% maintain 15 hours；Medicinal material coarse powder is put in climatic chamber, often dish
Placement thickness is 5mm, and arranging temperature is 55 DEG C (actual temperature is 50～60 DEG C), keeps drying sterilizing 8h；Conventional sense medical material
Microorganism situation in coarse powder, is repeated 2 times again, the microorganism situation in conventional sense medicinal material coarse powder；Must meet and directly take
The coarse powder that decoction pieces microbial limit requires；
3) breaking cellular wall: by particle diameter the medicinal material coarse powder of 100～120 mesh at room temperature and relative humidity in the environment of 70%, warp
Wall breaking pulverization, controls operating pressure and more than 30r/s, wall breaking pulverization to 300 mesh, obtains ultra-fine at 0.8MPa, grader rotating speed
Powder body (90% powder size is less than 45 microns)；
4) soft material processed: be placed in trough type mixing machine by prepared wall cell disruption powder, adds appropriate 80～99% ethanol, makes soft
Material；
5) pelletize: by step 4) the wall cell disruption powder soft material that makes puts in oscillating granulator forward direction screen cloth and spills a small amount of micropowder
Body, pelletizes with the screen cloth of 20 mesh, and during granulation, limit adds step 4) the wall cell disruption powder soft material that makes time limit add step 3) meat prepared
Osmanthus superfine powder, soft material is 6:0.5 with the ratio of superfine powder；
6) it is placed in 50 DEG C～60 DEG C of baking ovens is dried taking qualified breaking cellular wall decoction pieces granule, dried granule upper strata 10
Mesh, the concussion pelletizing machine granulate of bottom 24 mesh sieve sieves 3 times, and subpackage i.e. obtains Cortex Cinnamomi breaking cellular wall decoction pieces.
Leach time detecting test
Test method: take about 2g prepare dry granule be placed in the transparent cup of 300 milliliters, add 90 degrees Celsius Celsius to 95
100 milliliters of the water (being no longer heat up during shaking) of degree, shakes 1 minute, 2 minutes, 3 points with the clockwise direction of 1 circle per second
Clock, 5 minutes, see granule in cup after 10 minutes leach situation, separately take the American-European gram LS-609 laser grain of liquid 0.5 milliliter in cup
Degree instrument detection shading rate, result of the test see table 1:
Knowable to table 1 data, the method for granulating of the breaking cellular wall decoction pieces that the present invention provides is more preferable than the effect of conventional method of granulating,
Dissolution rate is than conventional method faster.
Microbial limit detection test
By " Chinese Pharmacopoeia " 2015 editions the 4th the 140-151 page
1105 non-sterile product microbial limit detections: microorganism count method
1106 non-sterile product microbial limit detections: Control bacteria examination method
1107 non-sterile medicine limitation standard in microbes
Medicinal material coarse powder after sterilizing the batch (-type) of embodiment 1～4 according to the method for pharmacopeia carries out microbial limit detection
Test, concrete outcome such as table 2:
The microbial limit detection test of the medicinal material coarse powder after the sterilization of table 2 batch (-type)
Knowable to table 2 data, batch (-type) method for disinfection is more preferable than conventional dry-air sterilization effect, more can guarantee that hygiology matter
Amount.
Active constituent content measuring is tested
By " Chinese Pharmacopoeia " 2015 editions first
Page 377 is about Semen Coicis detection method of content
Page 137 is about Cortex Cinnamomi detection method of content
Medicinal material coarse powder after sterilizing the batch (-type) of embodiment 1～4 according to the regulation of pharmacopeia carries out assay, specifically ties
Fruit is such as table 3:
The active constituent content measuring test of the medicinal material coarse powder after the sterilization of table 3 batch (-type)
As known from Table 3, the batch (-type) method for disinfection that the present invention uses is several without impact, energy on the medical material content of embodiment 1～4
The effective active constituent content keeping medicinal material coarse powder.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.All within the spirit and principles in the present invention, that is made any repaiies
Change, equivalent, improvement etc., should be included within the scope of the present invention.
Claims (10)
1. the preparation method of a breaking cellular wall decoction pieces, it is characterised in that there are following steps:
(1) medical material processes: medical material is prepared after picking the pulverizer pulverizing of cleanings/processs of preparing Chinese medicine, medicinal material drying, broken, 100 mesh sieves
The medicinal material coarse powder of 80～120 mesh；
(2) batch (-type) sterilization: the medicinal material coarse powder after step (1) being processed carries out sterilizing in climatic chamber-hypopus growth-
The process again sterilized, until obtaining meeting the medicinal material coarse powder directly taking decoction pieces microbial limit；
(3) breaking cellular wall: the medicinal material coarse powder after sterilization is ground into superfine powder；
(4) soft material processed: the superfine powder that breaking cellular wall prepares is placed in blender, makes soft material with the ethanol of water or variable concentrations；
(5) pelletize: soft material is made granule；
(6) breaking cellular wall decoction pieces will be prepared after particle drying.
The preparation method of a kind of breaking cellular wall decoction pieces the most according to claim 1, it is characterised in that interval in described step (2)
Concretely comprising the following steps of formula sterilization: (A) sterilizes: the medicinal material coarse powder after step (1) being processed is placed on a constant temperature in climatic chamber
Degree is lower keeps drying sterilizing a period of time；(B) hypopus growth: be 20～30 by medicinal material coarse powder temperature in climatic chamber
DEG C, relative humidity 70～80% environment in maintain 8～24 hours, then the temperature of climatic chamber is adjusted to 33～40
DEG C, relative humidity be adjusted to 83～92% maintain 8～24 hours；(C) sterilization again: further medicinal material coarse powder is placed on perseverance
Drying sterilizing a period of time at a certain temperature in constant temperature and humidity case；Microorganism situation in conventional sense medicinal material coarse powder, prepares symbol
Close the medicinal material coarse powder directly taking decoction pieces microbial limit；Described uniform temperature is 50～80 DEG C；Described a period of time be 0.5～
8 hours；The thickness that described medicinal material coarse powder is placed in climatic chamber is 5mm～30mm.
The preparation method of a kind of breaking cellular wall decoction pieces the most according to claim 2, it is characterised in that interval in described step (2)
After formula has sterilized, when the microbial limit in conventional sense medicinal material coarse powder does not meets the situation directly taking microbial limit,
Repeat the growth of (B) hypopus and (C) sterilization process 1～4 times；The medical material directly taking decoction pieces microbial limit is met until preparing
Coarse powder.
The preparation method of a kind of breaking cellular wall decoction pieces the most according to claims 1 to 2, it is characterised in that described step (1) Chinese medicine
Material be dried refer to medicinal material drying to water content below 10%；Described step (1) crushes and refers to the screen cloth of medical material 10 mesh
Mechanical crusher be broken into the little granule about 10 mesh.
The preparation method of a kind of breaking cellular wall decoction pieces the most according to claims 1 to 2, it is characterised in that system in described step (5)
Grain method particularly includes: the soft material the made granulator of 14～24 mesh sieves is pelletized, in granulator, is adding soft material
Adding superfine powder simultaneously, completing until preparing granule；Described granulator is oscillating granulator or the squash type of 14～24 mesh sieves
Granulator.
The preparation method of a kind of breaking cellular wall decoction pieces the most according to claim 5, it is characterised in that pelletize in described step (5)
Concrete grammar in, the ratio of soft material and superfine powder is 3～6:0.5～1.
The preparation method of a kind of breaking cellular wall decoction pieces the most according to claims 1 to 2, it is characterised in that in described step (6)
Grain is dried and carries out in heated-air circulation oven, design temperature 50～80 DEG C, is dried to moisture less than or equal to 7%.
The preparation method of a kind of breaking cellular wall decoction pieces the most according to claim 7, it is characterised in that granule in described step (6)
Completing dried, with upper strata 10 mesh, the concussion pelletizing machine granulate of bottom 24 mesh sieve sieves 1～3 time, makes between 10～24 mesh
Grain.
The preparation method of a kind of breaking cellular wall decoction pieces the most according to claims 1 to 2, it is characterised in that broken in described step (3)
Wall method particularly includes: at room temperature and relative humidity in the environment of 30～70%, through the medicinal material coarse powder warp of batch (-type) sterilization
Wall breaking pulverization obtains superfine powder, controls operating pressure 0.5～0.8MPa, grader rotating speed 20～40r/s, wall breaking pulverization
More than 300 mesh；Described room temperature refers to 18～26 DEG C.
The preparation method of a kind of breaking cellular wall decoction pieces the most according to claims 1 to 2, it is characterised in that in described step (4)
Blender is trough type mixing machine or wet mixing pelletizer, the ethanol of described variable concentrations refer to the concentration of ethanol be 30%～
99%.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108272881A (en) * | 2018-01-25 | 2018-07-13 | 贵州广济堂药业有限公司 | A kind of preparation method of Rosa roxburghii Tratt broken wall medicine materical crude slice |
| CN109512856A (en) * | 2018-12-20 | 2019-03-26 | 江西赣隆药业有限公司 | It is a kind of to have effects that clearing heat and detoxicating and invigorating spleen to remove dampness clover broken wall medicine materical crude slice and preparation method thereof |
| CN111035664A (en) * | 2019-12-31 | 2020-04-21 | 普洱淞茂滇草六味制药股份有限公司 | Preparation method of radix angelicae wall-broken decoction pieces |
| CN112999251A (en) * | 2019-12-19 | 2021-06-22 | 云南泰华丰功药业有限公司 | Preparation method of traditional Chinese medicine wall-broken decoction pieces |
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| CN101147746B (en) * | 2006-09-18 | 2011-02-16 | 中山市中智药业集团有限公司 | Method for processing traditional Chinese herbs broken wall powder |
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| CN101147746B (en) * | 2006-09-18 | 2011-02-16 | 中山市中智药业集团有限公司 | Method for processing traditional Chinese herbs broken wall powder |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272881A (en) * | 2018-01-25 | 2018-07-13 | 贵州广济堂药业有限公司 | A kind of preparation method of Rosa roxburghii Tratt broken wall medicine materical crude slice |
| CN109512856A (en) * | 2018-12-20 | 2019-03-26 | 江西赣隆药业有限公司 | It is a kind of to have effects that clearing heat and detoxicating and invigorating spleen to remove dampness clover broken wall medicine materical crude slice and preparation method thereof |
| CN112999251A (en) * | 2019-12-19 | 2021-06-22 | 云南泰华丰功药业有限公司 | Preparation method of traditional Chinese medicine wall-broken decoction pieces |
| CN111035664A (en) * | 2019-12-31 | 2020-04-21 | 普洱淞茂滇草六味制药股份有限公司 | Preparation method of radix angelicae wall-broken decoction pieces |
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