CN103271949B - A kind of directly oral medicinal slice production technology - Google Patents
A kind of directly oral medicinal slice production technology Download PDFInfo
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- CN103271949B CN103271949B CN201310209230.4A CN201310209230A CN103271949B CN 103271949 B CN103271949 B CN 103271949B CN 201310209230 A CN201310209230 A CN 201310209230A CN 103271949 B CN103271949 B CN 103271949B
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Abstract
The open a kind of directly oral medicinal slice production technology of the present invention, comprise the steps: to select, wash, demulcen, cut medicine, it is dried, sterilizing, pulverize, inner packing and outer package, whole process of manufacture is carried out in aseptic room, remain the aseptic degree in production environment, use the sterilization of ozone gas flow type, effectively ensure while sterilization that noresidue is polluted, Chinese crude drug after sterilizing carries out grinding and processing, reach the smashing fineness of 80～120 mesh, the powdery prepared slices of Chinese crude drugs use Sterile vacuum unit dose package, guarantee is deposited and transport does not results in secondary pollution.The prepared slices of Chinese crude drugs obtained by present invention process reach the most oral cleanliness factor, and smashing fineness height is available for human body and effectively absorbs, and the process that saving weighs boils is time saving and energy saving, and drug effect utilization rate is high.
Description
Technical field
The present invention relates to the production technology of a kind of prepared slices of Chinese crude drugs, particularly relate to a kind of directly oral medicinal slice production technology.
Background technology
The prepared slices of Chinese crude drugs refer to Chinese medicine as required, are processed into certain shape, it is simple to the one of use can be direct
Chinese medicine for tcm clinical practice.Chinese crude drug is after processing in production place, according to character and the needs of medical treatment of medical material, medicine
Certain specifications such as material is thinly sliced, sheet, inclined tab, thread, section shape, bulk, make effective ingredient be prone to
Dissolution, and it is convenient for other processes of preparing Chinese medicine and storage and adjustment etc., this Chinese crude drug is referred to as " decoction pieces ".
Prepared slices of Chinese crude drugs dispensing mode Chinese traditional medicine dispensing since the Song dynasty, always with weigh with a small steelyard scale weigh one by one be allocated as main, this
Allotment operating type be feasible under specific historical conditions, but along with society progress, its drawback by
Step displays, and staff stands operation, comes and goes and frequently walks about, work load weight；Medicine Bales Off is deposited,
Causing air pollution serious in colony's operation process, the phenomenon of indoor " dirty, unrest, difference " is more typically.Meanwhile, agent is divided
Amount is inaccurate, is difficult to check after the mixed bag of medicine, and medicine Wrong, missing is difficult to find and correct, and deployment operations and patient wait
The medicine time is long, takies manpower too much.
The consumption of tradition decoction pieces is big and needs to decoct, and one is fried cost-effectively, also functions to kill decoction pieces simultaneously and is carried
Antibacterial, but decoction pieces is thick big, effective ingredient decocting rate is low, and the effectively property of medicine also can after decocting for a long time
Suffering destruction in various degree, the drug effect utilization rate of traditional prepared slices of Chinese crude drugs is the lowest.And tradition decoction pieces packaging is simple and crude,
Predominantly gunnysack, grass (Pu, seat) bag, cloth bag, chemical fibre bag, easy taint of odour, does not has inner packing, illustrates and criticize
Number, lack unified specification.
Most Manufacture of medicinal slices of TCM enterprises are workshop-based processing stands, and working condition is simple and crude, raw quality inspection
Measurement equipment falls behind, and the modern operational management experience of enterprise and professional technician lack, so that the effective ingredient of medical material
Run off, decoction pieces cleanliness factor difficult quality guarantee.
Summary of the invention
The technical assignment of the technical problem to be solved and proposition is to improve prior art, it is provided that one
Planting direct oral medicinal slice production technology, solving the prepared slices of Chinese crude drugs in current technology needs to boil, and wastes time and energy, cleanliness factor
Low, that drug effect utilization rate is low problem.
For solving above technical problem, the technical scheme is that
A kind of directly oral medicinal slice production technology, comprise the steps: to select, wash, demulcen, cut medicine, be dried,
Sterilizing, pulverizing, inner packing and outer package, it is characterised in that select, wash, demulcen, cut medicine and dry life
Production. art flow process is in the clean area of 300,000 grades and carries out, at the technological process of production of sterilizing, pulverizing and inner packing
100,000 grades of airtight clean areas are carried out.
In the range of 100000 grades of airtight clean area ambient temperatures are maintained at 18～26 °, relative humidity is maintained at 45%～65%
In the range of, the illumination of working region maintains 250～300Lx, and 5.0um airborne is less than 20000/M3,
Sedimentation clump count is less than 10, and the prepared slices of Chinese crude drugs are sent to sterilizing cabinet through sterilizing cup after being dried and go out
Bacterium processes, and after sterilizing completes, the prepared slices of Chinese crude drugs are delivered to raw material storage chamber via sterilizing rear chamber, in after sterilizing
Medicine decoction pieces is tested its cleanliness factor, is then up to the prepared slices of Chinese crude drugs of cleanliness factor and is sent to pulverizing chamber and carries out ultra tiny
Pulverizing the smashing fineness reaching energy directly oral absorption, the prepared slices of Chinese crude drugs after pulverizing transport Nei Bao room via automatically
Packer is packaged in small package bag, and the prepared slices of Chinese crude drugs of small package bag are delivered to outsourcing room via rustless steel sterilizing passing cabinet
Carrying out outsourcing encapsulation, the work flow 100,000 grades of airtight clean areas ensure that Chinese medicine drink will not be secondarily contaminated,
Reach the most oral cleanliness factor.
The prepared slices of Chinese crude drugs people of lamellar or bulk cannot directly eat, and also cannot absorb drug effect therein, the most logical
Cross and boil and effective ingredient therein could be cooked, therefore the prepared slices of Chinese crude drugs are directly taken and typically require Chinese medicine
Material is ground into the fineness that human body can absorb, and the prepared slices of Chinese crude drugs also need to the cleanliness factor reaching directly to take on this basis,
Chinese crude drug grows in the wild, with a lot of harmful pathogenic bacterias on it, it is necessary to this pathogenic bacteria is removed and could directly be administered orally,
Otherwise these pathogenic bacterias one can cause the prepared slices of Chinese crude drugs to lose drug effect, and two can cause people to be attacked by a disease, so Chinese medicine
The cleanliness factor of decoction pieces have to be accomplished to ensure, it is necessary to is removed by the harmful levels of pathogens on the prepared slices of Chinese crude drugs, in addition it is also necessary to
Ensure during processing and packing not result in secondary pollution.Present invention process the prepared slices of Chinese crude drugs carry out sterilization treatment it
After, it being in 100,000 grades of airtight clean areas all the time and carry out follow-up processing and packaging, various process equipments and packaging material all enter
Crossing sterilization and process the requirement meeting GMP, the air quality of 100,000 grades of airtight clean areas is in monitoring shape all the time
State, it is ensured that the sterility of 100,000 grades of airtight clean areas, thus ensure that the prepared slices of Chinese crude drugs will not suffer two after sterilization
Secondary pollution, the prepared slices of Chinese crude drugs still can reach the most oral cleanliness factor after packaging.And use by gram single dose
Packaging, it is not necessary to weighing with a small steelyard scale allotment, the links such as weighing, divided dose, wrapping can be saved in operation, add fast speed, carry
High efficiency, shortens patient and waits the medicine time, and mistakes and omissions can be reduced or avoided.
Further, the described prepared slices of Chinese crude drugs use ozone sterilization mode, ozone gas to steam with water when carrying out sterilizing
Gas gas mixes, and ozone concentration is 30ppm, carries out flow type sterilization, forms aseptic prepared slices of Chinese crude drugs surface, goes out
Bacterium time 10～30 minutes, use catalysis type to purify exhaust mode and discharge oxygen and steam, it is to avoid steam remains
Destroy the property of medicine.. ozone, by the enzyme needed for oxidation Decomposition antibacterial endogenous glucose, makes bacteria inactivation dead；Ozone is also
Directly and antibacterial, virus function can destroy their organelle and DNA, RNA, make the new old generation of antibacterial
Thank and destroyed, cause bacterial death:. ozone can also pass through cell membrane tissue, invades intracellular, acts on film
Interior lipoprotein and internal lipopolysaccharide, change the permeability of cell, causes cell to dissolve dead.And ozone is not
Dead angle can be produced, it is thus also avoided that use discharge of poisonous waste and residual that other chemosterilant brings, and ozone without
Any residual and secondary pollution.Adding spore if steam has been because water can expand, cell wall is thinning, ozone
The inactivation ratio of spore can be greatly improved.This technique belongs to surface disinfection, the shortest plus sterilizing time, thus right
Decoction pieces ingredient does not the most affect.
Further, subtle powder smash is used when described prepared slices of Chinese crude drugs conducting powder is broken, with the crushed prepared slices of Chinese crude drugs
The part contacted all uses the stainless steel material with good corrosion resistance, and the prepared slices of Chinese crude drugs crushed are through sieve
Entering collecting box after mesh screen choosing, the smashing fineness of powder is 80～120 mesh, and the dust produced during pulverizing is inhaled by ESC
Dirt device reclaims through Bag filter.The fineness pulverized reaches the absorbable fineness of human body, and the prepared slices of Chinese crude drugs can be effectively ensured
Drug effect, uses vacuum cleaner to absorb the dust one produced when pulverizing and can be prevented effectively from the loss of material, and two is permissible
Breed bacteria is avoided to pollute 100,000 grades of airtight clean areas.
Further, described crushing process also use Low temperature regulation system realize low-temperature grinding, and according to material
Brittle point temperature, its temperature adjustable in crushing process, prevent the prepared slices of Chinese crude drugs due to pulverize heating and rotten with
And the dust explosion in crushing process.As strong fibroid (such as Ganoderma, Radix Glycyrrhizae etc.) high sugar high viscosity (as Fructus Lycii,
Radix Ophiopogonis etc.) resinae (such as Olibanum, Myrrha etc.) this class Chinese crude drug at normal temperatures be difficult to pulverize, it is impossible to
These Chinese crude drugs are crushed to 60～120 mesh, but will embrittlement reach easily to pulverize when temperature is reduced to a timing material
State, the most just by the method for low temperature, the Chinese crude drug of various, multi items can be implemented pulverizing and reach direct mouth
The fineness that clothes absorb.
Further, the described prepared slices of Chinese crude drugs are before Nei Bao room is wrapped inside dress, and small package bag is by interior packaging material room warp
Cross after rustless steel sterilizing passing cabinet carries out sterilization process and be delivered to Nei Bao room, it is to avoid secondary pollution, in Nei Bao room
The middle prepared slices of Chinese crude drugs carry out vacuum unit dose package in grams by automatic packaging machine, it is to avoid go mouldy, damage by worms, prolong
The long storage time, it is ensured that prepared slice quality.By weighing quantitatively, fractional pack is easy to take and store.Interior bag subpackage mistake
It is noted that check that loading amount is the most accurate in journey, sealing is the tightest, and material to be packaged is the most consistent with production ordering,
Packaging labels (lot number, date of manufacture, effect duration etc.) etc. are the most correct, it is to avoid cross-contamination with obscure.
Further, the described prepared slices of Chinese crude drugs use pressurization spraying-rinsing when wash, quickly clean medical material surface
Earth and impurity, it is to avoid excessively rinse and cause the effective ingredient of Chinese crude drug to run off.
Further, the described prepared slices of Chinese crude drugs use steam under pressure tank profit vexed when carrying out demulcen, and Stress control exists
1kg/cm2, temperature more than 100 DEG C, moisten 1 hour vexed time, it is also possible to play the effect of sterilizing, moisture quickly enters
Entering inside medical material, reach to run through water logging, shorten and moisten the vexed time, medical material is not directly contacted with water, controls effective ingredient
Run off.
Further, the described prepared slices of Chinese crude drugs when cutting medicine, Chinese crude drug is cut into thickness 1～2mm thin slice or
The section of 3～4mm, and the Chinese crude drug maximum particle size after cutting is less than the 8～12mm follow-up prepared slices of Chinese crude drugs of guarantee
Pulverize, Chinese crude drug granularity cross conference cause follow-up pulverize difficulty, do not put in pulverizer, therefore when cutting medicine in
Medical material maximum particle size must not exceed 8～12mm.
Further, the described prepared slices of Chinese crude drugs use indoor hot air to be dried when dry, and hot blast is inputted room by warm-air pipe
In, indoor add aerator, make hot air convection, reach homogeneous temperature, and temperature controls at 80～100 DEG C.Because using
High compressed steam profit is vexed, and medical material moisture is relatively low, and hot air drying shortens drying time, and processing cost is low.
Compared with prior art, the invention has the advantages that:
The prepared slices of Chinese crude drugs that direct oral medicinal slice production technology of the present invention is produced are processed at aseptic environment
Making, cleanliness factor is high, it is not necessary to boiling, can directly take, time saving and energy saving, safe and reliable, the prepared slices of Chinese crude drugs are fabricated to
Ultramicro powder, can direct oral absorption, drug effect utilization rate is high；
Present invention process uses after single dose subpackage, it is not necessary to allocate with weighing with a small steelyard scale, operation can be saved weighing, divided dose,
The links such as wrapping, add fast speed, improve efficiency, shorten patient and wait the medicine time, and mistakes and omissions can be reduced or avoided；Very
Empty package is conducive to Chinese medicine storage and custody and transport, can improve and ensure The Quality of Sliced Herbal Medicine；Both dialectical executing had been adapted to
Control, with the needs of disease plus-minus, some in medication can be overcome again random, it is ensured that safe and effective for medication；
Present invention process uses ozone sterilization, and the catabolite of ozone is oxygen, will not produce residual contamination.Another
Aspect, it is as gas, and diffusibility is good, and even concentration is especially in high humidity environment, more practical than uviol lamp,
And easy to operate, safe and reliable, human body is had no effect；
Present invention process uses low-temperature grinding, utilizes the characteristic that material is brittle when low temperature, and can pulverize room temperature cannot
The Chinese crude drug pulverized, can obtain the powder thinner than ambient ground；Can prevent material from aoxidizing change owing to pulverizing heating
Matter, keeps color and the nutrient content unchanged of ground product；The dust explosion in crushing process can be prevented,
Reduce noise.
Detailed description of the invention
Technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described
Embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention,
The every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all belongs to
In the scope of protection of the invention.
The open a kind of directly oral medicinal slice production technology of the embodiment of the present invention, it is provided that a kind of cleanliness factor reaches oral standard,
And can the Manufacture of medicinal slices of TCM technique of direct oral absorption drug effect.
A kind of directly oral medicinal slice production technology, comprise the steps: to select, wash, demulcen, cut medicine, be dried,
Sterilizing, pulverizing, inner packing and outer package, select, wash, demulcen, cut at medicine and the dry technological process of production
The clean area of 300,000 grades is carried out, the technological process of production of sterilizing, pulverizing and inner packing be in 100,000 grades airtight
Clean area is carried out.
Remove when selecting dis-medicinal part in medical material (as with scrape off cork, the aerial parts of ratio of rhizome medicinal material,
The cane of leaf class Chinese medicine, the leaf bar etc. of flos materia medica), be mixed into he plant plant (weeds, the form that are mixed into be close
Other plant etc.), inorganic impurity (stone, soil block), the feather of poultry, feces etc., complete for band root
Grass class herbelet medical material, then to sieve silt particle.
Use pressurization spraying-rinsing during wash, constantly stir, and speed wants fast, quickly cleans the mud on medical material surface
Soil and impurity, it is to avoid excessively rinse and cause the effective ingredient of Chinese crude drug to run off, reduce quality of medicinal material.
Demulcen mainly make the most dry medical material by vexed, moisten, the way such as bubble, increase water content to about 60-70%,
Make the aqueous inside and outside uniformity of medical material.The prepared slices of Chinese crude drugs use steam under pressure tank profit vexed when carrying out demulcen, Stress control
At 1kg/cm2, temperature more than 100 DEG C, moisten 1 hour vexed time, moisture rapidly enters inside medical material, reaches to run through
Water logging, shortens and moistens the vexed time, and medical material is not directly contacted with water, controls the loss of effective ingredient.Avoid using cold water demulcen,
Cause active ingredient to hydrolyze, reduce quality of medicinal material.
When cutting medicine, Chinese crude drug is cut into thin slice or the section of 3～4mm of thickness 1～2mm, and after cutting in
Medical material maximum particle size is less than the pulverizing of the 8～12mm follow-up prepared slices of Chinese crude drugs of guarantee.To want according to configuration of medicinal materials and use
Ask, use suitable mode to reduce loss, increase operation rate.
Using indoor hot air to be dried when being dried, hot blast is by warm-air pipe input indoor, and indoor add aerator, make hot blast
Convection current, reaches homogeneous temperature, and temperature controls at 80～100 DEG C.
In the range of 100000 grades of airtight clean area ambient temperatures are maintained at 18～26 °, relative humidity is maintained at 45%～65%
In the range of, the illumination of working region maintains 250～300Lx, and 5.0um airborne is less than 20000/M3,
Sedimentation clump count is less than 10, and the prepared slices of Chinese crude drugs are sent to sterilizing cabinet through sterilizing cup after being dried and go out
Bacterium processes, and after sterilizing completes, the prepared slices of Chinese crude drugs are delivered to raw material storage chamber via sterilizing rear chamber, in after sterilizing
Medicine decoction pieces is tested its cleanliness factor, is then up to the prepared slices of Chinese crude drugs of cleanliness factor and is sent to pulverizing chamber and carries out ultra tiny
Pulverizing the smashing fineness reaching energy directly oral absorption, the prepared slices of Chinese crude drugs after pulverizing transport Nei Bao room via automatically
Packer is packaged in small package bag, and the prepared slices of Chinese crude drugs of small package bag are delivered to outsourcing room via rustless steel sterilizing passing cabinet
Carrying out outsourcing encapsulation, the work flow 100,000 grades of airtight clean areas ensure that Chinese medicine drink will not be secondarily contaminated,
Reach the most oral cleanliness factor.
Using ozone sterilization mode during sterilizing, ozone gas mixes with water vapor gas, and ozone concentration is 30ppm,
Carry out flow type sterilization, form aseptic prepared slices of Chinese crude drugs surface, sterilization time 10～30 minutes, use catalysis type clean
Change exhaust mode and discharge oxygen and steam, it is to avoid steam residual destroys the property of medicine.
During pulverizing use subtle powder smash, the part contacted with the crushed prepared slices of Chinese crude drugs all use have the most resistance to
Corrosive stainless steel material, the prepared slices of Chinese crude drugs crushed enter collecting box, the pulverizing of powder through screen cloth after screening
Fineness is 80～120 mesh, and the dust produced during pulverizing is reclaimed through Bag filter by ESC vacuum cleaner.In crushing process
Low temperature regulation system is also used to realize low-temperature grinding, and according to the brittle point temperature of material, its temperature in crushing process
Degree controllable, prevents the prepared slices of Chinese crude drugs owing to pulverizing heating and dust explosion in rotten and crushing process.
The prepared slices of Chinese crude drugs are before Nei Bao room is wrapped inside dress, and small package bag is transmitted through rustless steel sterilizing by interior packaging material room
Cabinet is delivered to Nei Bao room after carrying out sterilization process, it is to avoid secondary pollution, and in Nei Bao room, the prepared slices of Chinese crude drugs are by certainly
Dynamic packer carries out vacuum unit dose package in grams, it is to avoid goes mouldy, damage by worms, and extends the storage time.Pass through
Weighing quantitatively, fractional pack is easy to take and store.It is noted that check that loading amount is the most accurate during interior bag subpackage, envelope
Whether mouthful tight, material to be packaged is the most consistent with production ordering, and packaging label is (lot number, the date of manufacture, effective
Phase etc.) etc. the most correct, it is to avoid cross-contamination with obscure.The prepared slices of Chinese crude drugs of small package bag go out via rustless steel
Bacterium passing cabinet is delivered to outsourcing room and carries out outsourcing encapsulation.
The direct oral medicinal slice aseptic degree of gained of the present invention is high, and smashing fineness is high, can directly oral absorption, province
Going the process boiled, property of medicine utilization rate is high.Using ozone sterilization, noresidue is polluted, and uses vacuum packaging, also protects
Demonstrate,prove and deposited in transportation in the later stage, do not had secondary pollution.
Below it is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred implementation is not construed as
Limitation of the present invention, protection scope of the present invention should be as the criterion with claim limited range.For this skill
For the those of ordinary skill in art field, without departing from the spirit and scope of the present invention, it is also possible to make some changing
Entering and retouch, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (5)
1. a direct oral medicinal slice production technology, comprise the steps: to select, wash, demulcen, cut medicine, it is dried, sterilizing, pulverize, inner packing and outer package, it is characterized in that, select, wash, demulcen, cut medicine and the dry technological process of production is in the clean area of 300,000 grades and carries out, sterilizing, the technological process of production of pulverizing and inner packing is in 100,000 grades of airtight clean areas and carries out, in the range of 100000 grades of airtight clean area ambient temperatures are maintained at 18～26 °, in the range of relative humidity is maintained at 45%～65%, the illumination of working region maintains 250～300Lx, 5.0 μm airbornes are less than 20000/M3Sedimentation clump count is less than 10, the described prepared slices of Chinese crude drugs use pressurization spraying-rinsing when wash, quickly clean earth and the impurity on medical material surface, avoid excessively rinsing and cause the effective ingredient of Chinese crude drug to run off, the prepared slices of Chinese crude drugs use steam under pressure tank profit vexed when carrying out demulcen, and Stress control is at 1kg/cm2null，Temperature more than 100 DEG C，Moisten 1 hour vexed time，The prepared slices of Chinese crude drugs are sent to sterilizing cabinet through sterilizing cup after being dried and carry out sterilization treatment，After sterilizing completes, the prepared slices of Chinese crude drugs are delivered to raw material storage chamber via sterilizing rear chamber，The prepared slices of Chinese crude drugs after sterilizing are tested its cleanliness factor，Then be up to the prepared slices of Chinese crude drugs of cleanliness factor be sent to pulverizing chamber carry out that subtle powder smash reaches can the smashing fineness of direct oral absorption，The prepared slices of Chinese crude drugs after pulverizing transport Nei Bao room and are packaged in small package bag via automatic packaging machine，The prepared slices of Chinese crude drugs of small package bag are delivered to outsourcing room via rustless steel sterilizing passing cabinet and carry out outsourcing encapsulation，Work flow 100,000 grades of airtight clean areas ensure that the prepared slices of Chinese crude drugs will not be secondarily contaminated，Reach the most oral cleanliness factor，The described prepared slices of Chinese crude drugs use ozone sterilization mode when carrying out sterilizing，Ozone gas mixes with water vapor gas，Ozone concentration is 30ppm，Carry out flow type sterilization，Form aseptic prepared slices of Chinese crude drugs surface，Sterilization time 10～30 minutes，Use catalysis type to purify exhaust mode and discharge oxygen and steam，Steam residual is avoided to destroy the property of medicine，The described prepared slices of Chinese crude drugs use indoor hot air to be dried when dry，Hot blast is by warm-air pipe input indoor，Indoor add aerator，Make hot air convection，Reach homogeneous temperature，Temperature controls at 80～100 DEG C.
Direct oral medicinal slice production technology the most according to claim 1, it is characterized in that, subtle powder smash is used when described prepared slices of Chinese crude drugs conducting powder is broken, the part contacted with the crushed prepared slices of Chinese crude drugs all uses the stainless steel material with good corrosion resistance, the prepared slices of Chinese crude drugs crushed enter collecting box through screen cloth after screening, the smashing fineness of powder is 80～120 mesh, and the dust produced during pulverizing is reclaimed through Bag filter by ESC vacuum cleaner.
Direct oral medicinal slice production technology the most according to claim 2, it is characterized in that, described crushing process also use Low temperature regulation system realize low-temperature grinding, and according to the brittle point temperature of material, its temperature adjustable in crushing process, prevents the prepared slices of Chinese crude drugs owing to pulverizing heating and dust explosion in rotten and crushing process.
4. according to the direct oral medicinal slice production technology described in any one of claims 1 to 3, it is characterized in that, the described prepared slices of Chinese crude drugs are before Nei Bao room is wrapped inside dress, small package bag is delivered to Nei Bao room by interior packaging material room after rustless steel sterilizing passing cabinet carries out sterilization process, avoid secondary pollution, in Nei Bao room, the prepared slices of Chinese crude drugs carry out vacuum unit dose package in grams by automatic packaging machine, it is to avoid go mouldy, damage by worms, and extend the storage time.
Direct oral medicinal slice production technology the most according to claim 4, it is characterized in that, Chinese crude drug is cut into thin slice or the section of 3～4mm of thickness 1～2mm by the described prepared slices of Chinese crude drugs when cutting medicine, and the Chinese crude drug maximum particle size after cutting is less than the pulverizing of the 8～12mm follow-up prepared slices of Chinese crude drugs of guarantee.
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| CN102772440A (en) * | 2012-05-24 | 2012-11-14 | 周明千 | Processing method of ultra-micro wall-breaking oral-tablet decoction pieces by traditional Chinese medicines |
| CN102836180A (en) * | 2012-09-28 | 2012-12-26 | 四川泰乐制药有限公司 | Technology for preparing traditional Chinese medicine decoction pieces through compression and sterilization |
| CN102846698A (en) * | 2012-08-20 | 2013-01-02 | 浙江中医药大学中药饮片有限公司 | Wall-broken radix tetrastigme oral decoction pieces |
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2013
- 2013-05-30 CN CN201310209230.4A patent/CN103271949B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228468A (en) * | 2011-06-29 | 2011-11-02 | 广州市药材公司中药饮片厂 | Preparation method for granular Chinese herbal pieces |
| CN102772440A (en) * | 2012-05-24 | 2012-11-14 | 周明千 | Processing method of ultra-micro wall-breaking oral-tablet decoction pieces by traditional Chinese medicines |
| CN102846698A (en) * | 2012-08-20 | 2013-01-02 | 浙江中医药大学中药饮片有限公司 | Wall-broken radix tetrastigme oral decoction pieces |
| CN102836180A (en) * | 2012-09-28 | 2012-12-26 | 四川泰乐制药有限公司 | Technology for preparing traditional Chinese medicine decoction pieces through compression and sterilization |
Non-Patent Citations (1)
| Title |
|---|
| 中药饮片GMP补充规定;国家药品监督管理局;《中药研究与信息》;20030626;第5卷(第6期);第10、42页 * |
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