CN101653518B - Medicinal composition for treating child diarrhea and child infectious diarrhea and preparation method - Google Patents
Medicinal composition for treating child diarrhea and child infectious diarrhea and preparation method Download PDFInfo
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- CN101653518B CN101653518B CN2008100510916A CN200810051091A CN101653518B CN 101653518 B CN101653518 B CN 101653518B CN 2008100510916 A CN2008100510916 A CN 2008100510916A CN 200810051091 A CN200810051091 A CN 200810051091A CN 101653518 B CN101653518 B CN 101653518B
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Abstract
The invention aims to develop a medicinal composition for treating child diarrhea and child infectious diarrhea capable of treating both principal and secondary aspects of diseases, restraining and killing bacteria, building up bodies without influencing infant growth, containing various trace elements and having synergistic action with 'oral rehydration solution' as well as a preparation method. The effective rate of the medicinal composition reaches 85 percent when the medicinal composition is used to treat infectious diarrhea caused by spleen vacuity or cold, damp heat, summer heat and improper diet; moreover, the medicinal composition has outstanding therapeutic effects on fever, bellyache, abdominal distention, anabole, anorexia, and the like accompanied with diarrhea; therefore, the medicinal composition is suitable for eliminating dampness to stop diarrhea, and regulating the middle warmer and invigorating the spleen, and can be used to treat child diarrhea (with the symptoms of diarrhea, thin sloppy or watery stool, abdominal distention, bellyache, anorexia, anabole or fever, pale tongue and white and greasy tongue coat) caused by dampness encumbering spleen earth as well as rotavirus enteritis and infectious diarrhea with the syndromes. The preparation method comprises the following step: taking raw medicinal materials including cablin potchouli herb, Chinese atractylodes rhizome, Indian buead, oriental waterplantain rhizome, officinal magnolia bark (prepared with ginger), plantain herb, tangerine peel and medicated leaven (fried) to make the medicinal composition through cleansing, processing, blending, extraction, refining, filtration, concentrated preparation, filling, leak detection, packaging, and the like. The medicinal composition has the advantages of unique formula, reasonable preparation and ideal therapeutic effects on child diarrhea and child infectious diarrhea.
Description
One. technical field
The present invention relates to a kind of treatment infantile diarrhea and child infectious diarrheal drug regimen and preparation method.Belong to field of medicaments, be applicable to eliminating dampness to stop diarrhea and middle activating the spleen, be used for the wet infantile diarrhea that is stranded due to the spleen soil, disease is seen: have loose bowels, loose stool or water sample, abdominal distention, stomachache, poor appetite, vomiting or see that greasy in vain and rotaviral enteritis of heating, light red tongue, tongue and noninfectious diarrhea see above-mentioned patient.
Two. the technology figure viewed from behind
Infantile diarrhea is China's infant commonly encountered diseases, have a strong impact on the child particularly health and the growth promoter of infant, mainly used the Western medicine antibiotic therapy in the past, but the big and present Chinese medicine diarrhea of Western medicine toxic and side effects is only treated at the digestive tract function disorder that weakness of the spleen and stomach causes.The wide plain antidiarrhea oral liquid of children's just in time remedies the deficiency of front diarrhea, has no side effect, and can suppress and kills escherichia coli and rotavirus, has spleen benefiting and stimulating the appetite concurrently, brings down a fever, helps digestion and effect such as human body immunity improving power.Simultaneously, this product is rich in body trace elements such as potassium, sodium, magnesium, zinc, and dehydration, electrolyte imbalance that diarrhoea is caused have regulating action.
This product is before new drug research, treat infantile diarrhea 159 examples altogether from-nineteen eighty-three in 1978, and compare with 159 routine Western medicine groups, the result shows: the wide plain antidiarrhea oral liquid of children's bring down a fever, effect such as preventing or arresting vomiting, antidiarrheal is better than the Western medicine group, children's is easy to accept clinically, is free from side effects.The Clinical Researches of New Drugs of this medicine is to carry out in the specified clinical bases of four countries of family such as Henan College Of Traditional Chinese Medicines, through the clinical observation in 3 years, amounts to and observes infant 477 examples, and total effective rate reaches 78.69%.The clinical observation conclusion is: it is fast that the wide plain antidiarrhea oral liquid treatment infantile rotavirus enteritis of children's, Escherichia coli enteritis and noninfectious diarrhea have antidiarrheal speed, good effect, characteristics such as safety non-toxic.
This product to by insufficiency of the spleen or be affected by the cold, noninfectious diarrhea effective percentage that damp and hot, summer-heat and improper diet cause reaches 85%, to diarrhoea with heating, stomachache, abdominal distention, vomiting, poor appetite etc. good therapeutical effect is all arranged.The clinical symptom disappearance rate is respectively 96%, 94%, 99%, 98% and 85%, and rapid-action.Simultaneously, this product is rich in body trace elements such as potassium, sodium, magnesium, zinc, and dehydration, electrolyte imbalance that diarrhoea is caused have regulating action.By studies have shown that of aspects such as the system's pharmacology pharmacodynamics in surplus ten years, toxicology, production technology, quality standard: this product controllability is strong, and clinical efficacy is definite, does not have toxic and side effects.
Pharmacodynamic experiment shows that the wide plain antidiarrhea oral liquid of children's plays anti-diarrhea effect by suppressing the gastrointestinal motility function, and confirms that by experiment the wide plain antidiarrhea oral liquid of children's is to escherichia coli O
55And the diarrhoea due to the rotavirus has significant curative effect.Antibacterial separating resulting in the colibacillosis breast rabbit of the wide plain antidiarrhea oral liquid treatment of children's proves that this medicinal liquid has inhibition and kills colibacillary effect.Experiment also shows, this medicinal liquid can strengthen the phagocytic activity of mice with spleen deficiency macrophage, and having the effect that significantly improves mice with spleen deficiency blood antibody formation on every side, the raising of immunologic function is for enhancing body antiviral, antibacterium ability and promote the reparation of gastrointestinal pathological changes also to play an important role.
Three. goal of the invention
The present invention is a kind of pure Chinese medicinal preparation of exploitation, has treating both the principal and secondary aspects of a disease, can suppress killing pathogenic bacteria, the energy building body of holding concurrently does not influence the growth promoter of infant, is rich in various trace elements, with " oral rehydration " synergistic treatment infantile diarrhea and child infectious diarrheal drug regimen and preparation method is arranged.
Four. technical scheme
1. fill a prescription
Ingredient of the present invention has: Herba Pogostemonis, Rhizoma Atractylodis, Poria, Rhizoma Alismatis, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), Herba Plantaginis, Pericarpium Citri Reticulatae, Massa Medicata Fermentata (stir-fry).
Pharmaceutical formulation of the present invention is formed weight proportion scope (4000): specification: 10ml/ props up, in batches: 20000.
Cortex Magnoliae Officinalis 1～1000kg, Herba Plantaginis 1～1000kg, Rhizoma Alismatis 1～1000kg, Pericarpium Citri Reticulatae 1～1000kg, Rhizoma Atractylodis 1～1000kg, Poria 1～1000kg, Massa Medicata Fermentata 1～1000kg, Herba Pogostemonis 1～1000kg.
The solubilizing agent kind weight proportion scope that the present invention uses following one or more:
Solubilizing agent: Tween 80 (1-99%), polysorbas20 (1-99%), polysorbate40 (1-99%), polysorbate60 (1-99%).
Antiseptic: sodium benzoate 1-99%, Potassium Benzoate 1-99%, sorbic acid 1-99%, dehydroacetic acid 1-99%.
Correctives: sucrose 0.1-100kg, glucose 0.1-100kg, fructose 0.1-100kg, liquid glucose 1-99%.
2. preparation method
Get crude drug Herba Pogostemonis, Rhizoma Atractylodis, Poria, Rhizoma Alismatis, Cortex Magnoliae Officinalis, Herba Plantaginis, Pericarpium Citri Reticulatae, Massa Medicata Fermentata, through making only, concoct, prepare burden, extract, make with extra care, filter, concentrating processes such as preparation, fill, leak detection, packing promptly.
Five, technological merit
Advantage of the present invention is: prescription is unique, and method for making is reasonable; Belong to field of medicaments, be applicable to eliminating dampness to stop diarrhea and middle activating the spleen.Be used for the wet infantile diarrhea that is stranded due to the spleen soil.Disease is seen: have loose bowels, loose stool or water sample, abdominal distention, stomachache, poor appetite, vomiting or see that greasy and rotaviral enteritis of heating, pale tongue with white fur and noninfectious diarrhea see above-mentioned patient.
Six, embodiment
1. the pre-treatment process of crude drug and process conditions (comprise the process of preparing Chinese medicine, extraction, concentrate)
1.1 Herba Pogostemonis
1.1.1 clean system: the material of getting it filled is put in and selects on the medicine workbench, selects, and removes impurity such as earth, dis-medicinal part, then, be put in the wash groove and use water wash, every drip washing in 5 minutes once, each drip washing was total to drip washing 10 times in 2 minutes, after the last drip washing, cover with wet cloth, moistening 20 minutes is standby.
1.1.2 cutting: will moisten good medical material and be cut into segment about 10～15mm with medicine cutter.
1.1.3 dry: the medical material after will cutting, be tiled in the basin, the about 2cm of thickness is put in the drying baker, and 50-60 ℃ of drying in the dry run, stirred medical material every 2 hours and once and with basin changed up and down.Dry 10-12 hour, treat that medical material moisture reduces to 12% and take out when following, the cold of drying in the air is weighed, and is loaded in the clean container, seals, and is labelled, and (dated medical material title, specification, lot number, weight, processing date, operator etc.) calculated yield is gone into intermediate station.
1.2 Pericarpium Citri Reticulatae
1.2.1 clean system: the material of getting it filled is put in and selects on the medicine workbench, selects, and removes impurity such as earth, dis-medicinal part, be put in then in the wash groove and use water wash, every drip washing in 5 minutes once, each drip washing was total to drip washing 5 times in 2 minutes, after the last drip washing, cover with wet cloth, moistening 20 minutes is standby.
1.2.2 cutting: will moisten good medical material is cut into 3～5mm with medicine cutter silk.
1.2.3 dry: the medical material after will cutting, be tiled in the basin, the about 2cm of thickness is put in the drying baker, and 50-60 ℃ of drying in the dry run, stirred medical material every 2 hours and once and with basin changed up and down.Dry 10-12 hour, treat that medical material moisture reduces to 12% and take out when following, the cold of drying in the air is weighed, and is loaded in the clean container, seals, and is labelled, and (dated medical material title, specification, lot number, weight, processing date, operator etc.) calculated yield is gone into intermediate station.
1.3 Rhizoma Atractylodis
1.3.1 clean system: the material of getting it filled is put in and selects on the medicine workbench, selects, and removes impurity such as earth, dis-medicinal part, then, be put in the wash groove and use water wash, every drip washing in 5 minutes once, each drip washing was total to drip washing 10 times in 2 minutes, after the last drip washing, cover with wet cloth, moistening 90 minutes, standby.
1.3.2 cutting: will moisten good medical material is cut into 2～4mm with medicine cutter sheet.
1.3.3 dry: the medical material after will cutting, be tiled in the basin, the about 2cm of thickness is put in the drying baker, and 50-60 ℃ of drying in the dry run, stirred medical material every 2 hours and once and with basin changed up and down.Dry 10-12 hour, treat that medical material moisture reduces to 12% and take out when following, the cold of drying in the air is weighed, and is loaded in the clean container, seals, and is labelled, and (dated medical material title, specification, lot number, weight, processing date, operator etc.) calculated yield is gone into intermediate station.
1.4 Cortex Magnoliae Officinalis
1.4.1 clean system: the material of getting it filled is put in and selects on the medicine workbench, selects, and removes impurity such as earth, dis-medicinal part, then, be put in the wash groove and use water wash, every drip washing in 5 minutes once, each drip washing was total to drip washing 10 times in 2 minutes, after the last drip washing, cover with wet cloth, moistening 50 minutes is standby.
1.4.2 cutting: will moisten good medical material is cut into 3～5mm with medicine cutter silk.
1.4.3 dry: the medical material after will cutting, be tiled in the basin, the about 2cm of thickness is put in the drying baker, and 50-60 ℃ of drying in the dry run, stirred medical material every 2 hours and once and with basin changed up and down.Dry 10-12 hour, treat that medical material moisture reduces to 12% taking-up when following, the cold of drying in the air is weighed, and is standby.
1.4.4 concoct: get Rhizoma Zingiberis Recens, clean and mash, add water 1L squeezing extracting juice, Rhizoma Zingiberis Recens dregs adds water 1L again and repeats squeezing once, merges juice; Get clean Cortex Magnoliae Officinalis and mix thoroughly with Sucus Zingberis, treat that the saturating juice of medicine is most, put in the medicine roasting machine, fry with slow fire (frying 200～350 ℃ of medicine temperature) and do, taking-up is dried.Weigh, be loaded in the clean container, seal, labelled, (indicating medical material title, specification, lot number, weight, processing date, operator etc.) calculated yield is gone into intermediate station.
1.5 Poria
1.5.1 clean system: the material of getting it filled is put in and selects on the medicine workbench, selects, and removes impurity.Weigh, be loaded in the clean container, seal, labelled, (indicating medical material title, specification, lot number, weight, processing date, operator etc.) calculated yield is gone into intermediate station.
1.6 Massa Medicata Fermentata
1.6.1 clean system: the material of getting it filled is put in and selects on the medicine workbench, selects, and removes impurity.Standby.
1.6.2 concoct: the medical material after the choosing is put in the medicine roasting machine, fries to little yellow with slow fire (frying 200～350 ℃ of medicine temperature), takes out the cold of drying in the air.Weigh, be loaded in the clean container, seal, labelled, (indicating medical material title, specification, lot number, weight, processing date, operator etc.) calculated yield is gone into intermediate station.
1.7 Rhizoma Alismatis
1.7.1 clean system: the material of getting it filled is put in and selects on the medicine workbench, selects, and removes impurity such as earth, then, drip washing is clean repeatedly to be put in the interior water of medicine-washing machine, places in the demulcen groove, adds 1～1.5 times of water gaging, cover with wet cloth, and moistening 5 hours, permeable most to medicine, take out standby.
1.7.2 cutting: will moisten good medical material is cut into 2～4mm with medicine cutter sheet.
1.7.3 dry: the medical material after will cutting, be tiled in the basin, the about 2cm of thickness is put in the drying baker, and 60 ℃～80 ℃ dryings in the dry run, were stirred medical material every 2 hours and once and with basin are changed up and down.Dry 10-12 hour, treat that medical material moisture reduces to 12% and take out when following, the cold of drying in the air is weighed, and is loaded in the clean container, seals, and is labelled, and (dated medical material title, specification, lot number, weight, processing date, operator etc.) calculated yield is gone into intermediate station.
1.8 Herba Plantaginis
1.8.1 clean system: the material of getting it filled is put in and selects on the medicine workbench, selects, and removes impurity, weighs, and is loaded in the clean container, seals, and is labelled, (indicating medical material title, specification, lot number, weight, processing date, operator etc.) calculated yield is gone into intermediate station.SOP is carried out in operation.
Cleaning is carried out SOP.
2. extract operating process and process conditions
2.1 extract
2.1.1 steam distillation extracts volatile oil
Get Herba Pogostemonis, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, be put in the multi-function extractor, adding water 1500kg soaked 1 hour, feed water vapour then and be heated to and boil, open condenser, condensed fluid is entered in the oil water separator, distillation time is 5 hours, (volatile oil yield 〉=0.85%) tells volatile oil, and is standby.Aqueous solution after the distillation (about 1000L) device is in addition collected, and is standby.
Medicinal residues behind the extraction volatile oil add Poria, Rhizoma Alismatis, Herba Plantaginis, Massa Medicata Fermentata again, and decocting boils secondary then, and decocting temperature is 100 ℃, add water 2400L for the first time, decoct 1.5 hours; Adding for the second time water 1800L decocted 1 hour.Merge then secondary decocting liquid and the distillation after aqueous solution, filter with fin filter 200 order filter clothes, the decompression of filtrate usefulness economic benefits and social benefits concentration tank (0.06Mpa～-0.09Mpa) concentrate, 50～70 ℃ of steam pressure 0.1～0.2Mpa, temperature, being concentrated into relative density is 1.12～1.14 (60 ℃ of surveys), emits concentrated solution.
2.1.2 supercritical fluid extraction volatile oil
Get Herba Pogostemonis, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae supercritical fluid extraction volatile oil.Impose a condition: in the scope of extracting pressure 10～25MPa, 33～48 ℃ of extraction temperature, CO2 flow 2～4L/min.Earlier extraction kettle and separating still are carried out preheating, storage is irritated and is then cooled off.When reaching predetermined temperature, open CO
2Gas cylinder is supplied gas, and opens high-pressure pump and boost, and when reaching predetermined pressure, the beginning cycling extraction is regulated CO
2Flow behind the constant temperature and pressure, after the extraction scheduled time, is collected extract from separating still, and is standby.
2.1.3 precipitate with ethanol
(about 65L) puts into 2M with concentrated solution
3In the Alcohol-settling tank, start stirring arm, slowly add 95% ethanol, make that to contain concentration of alcohol in the solution be 75%,, the Alcohol-settling tank interlayer feeds cold water cooling (5-10 ℃) 24 hours, emits supernatant then, with tube centrifuge centrifugal after, standby.
2.1.4 recovery ethanol
Get above-mentioned supernatant be added to feed in the economic benefits and social benefits concentration tank steam (0.1～0.15MPa) reclaims ethanol to there not being the alcohol flavor, then extractum is emitted, the about 58～63L of extractum, relative density 1.14 (60 ℃) is standby.
2.1.5 water precipitating
To reclaim alcoholic acid medicinal liquid and put into settling tank, add purified water, stir, cooling (5～10 ℃) 24 hours to 90L, filter, pack in the clean container, seal, labelled, (indicating medical material title, specification, lot number, weight, processing date, operator etc.) calculated yield is gone into freezer.
3. preparation operating process and process conditions
3.1 preparation
3.1.1 preparation simple syrup
In sugar boiler, add purified water, open the steam valve heating, when temperature reaches 60 ℃, add sucrose, heat while stirring, seethed with excitement 10 minutes, use filter (80 order) filtered while hot quickly, (compressed air pressure keeps 0.15Mpa).
3.1.2 dosing
The simple syrup for preparing in the water extracted immersing paste, volatile oil (with 13L tween 80 mixing), sodium benzoate and the 3.1.1 item that batch materials extracted is placed the dense filling of joining, stirred 20～30 minutes, stir evenly the back and add purified water, start magnetic stirrer 30～40 minutes, to even.
3.1.3 filter
The medicinal liquid that stirs is filtered (0.8um) with cylindrical filter cartridge, rate of filtration 200L/ hour, please test after the filtration.The inspection of semifinished product (1) clarity: be clear liquid.
(2) pH value is in the 5.0-7.0 scope; Relative density: be not less than 1.115.
3.1.4 store
Filtered liquid medicine is pumped in the hold-up tank, and room temperature is preserved, fill after the assay was approved.
3.2 fill, leak detection
3.2.1 fill
The fill amount: 10.0～10.4ml/ props up.Adjust plastics and become extremely following state of bottle filling machine: cooling circulating water is opened, and temperature of heating plate is added to 140-150 ℃, and heat-seal temperature is added to 140-150 ℃, compressed air pressure 0.6MPa, and die-cut speed 10-18 plate/minute, packaging material are the PVC/PE composite sheet.Start rolling inspection hollow plate molding situation, fill is carried out in qualified back (standard meets the presentation quality standard of finished product), per hour takes a sample in pouring process 1～2 time, gets 5 at every turn, checks the medicinal liquid loading amount.The filling formation product detect defective work at any time by inspection plate worker, and fill certified products sign indicating number is prepared leak detection in clean stainless (steel) wire dish.
3.2.2 leak detection
With the stainless net that the fill certified products are housed check and regulate pile up together the leak detection cabinet trolley bracket on, push the leak detection cabinet in, fasten the cabinet door, open vacuum pump, treat pressure reach-0.05MPa after, kept 10 minutes, destroy vacuum, open the cabinet door, take out the medicine after hunting leak, check whether leakage is arranged, certified products packed in the clean Turnover Box that every case is labelled, indicate the name of an article, lot number, date of manufacture, quantity, and check signature, and to go into intermediate station and store, defective work is destroyed.
3.2.3 sterilization
The certified products of will hunting leak are packed into and are sealed in the specified containers, deliver to the appointed place with cobalt 60 irradiations, and exposure dose is 5KGY.
3.3 packing
3.3.1 visual inspection checks in the medicinal liquid whether impurity, foreign body are arranged, and certified products are packed in the Turnover Box, every case is labelled, indicates the name of an article, lot number, date of manufacture, quantity, and checks signature, and defective work disappears and ruins.
3.3.1 the folding description is with twice of the horizontal doubling of paper folder.
3.3.2 printing lot number accurately clearly prints lot number and expiration date, date of manufacture at the lot number place of capsule, big case.
3.3.3 medicine is put in the bottle holder, in the capsule of packing into, put a description on the medicine plate, the two ends lid is built, and respectively pastes 19mm in both sides lid opening part center and seals one of label.
3.3.4 after packing finishes, product is gone into the finished product Holding Area, please test, handle warehouse-in formality and warehouse-in after qualified.
Seven, description of drawings:
Be the technical process of more detailed description embodiment, the draw craft flow chart sees Figure of description for details.
Fig. 1: pre-treating technology flow process.
Annotate: temperature of ice house: 0-5 ℃.
Fig. 2: preparation process flow chart.
Annotate:
1. in the frame of broken lines 100,000 grades of clean areas.
2. clean area is interior temperature: 18-26 ℃: relative humidity: 45-65%.
3. clean area and outdoor differential static pressure 〉=10Pa: the differential static pressure 〉=5Pa in the district between different brackets and district and the non-clean area.
4.. each station illumination 〉=300Lux in the district.
Claims (2)
1. treat infantile diarrhea and child infectious diarrheal pharmaceutical composition for one kind, it is characterized in that:
Medicine material composition and weight proportion scope are as follows: as must a large amount of pharmacy scaling up dose;
Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 1～1000kg, Herba Plantaginis 1～1000kg, Rhizoma Alismatis 1～1000kg, Pericarpium Citri Reticulatae 1～1000kg, Rhizoma Atractylodis 1～1000kg, Poria 1～1000kg, stir-fry Massa Medicata Fermentata 1～1000kg, Herba Pogostemonis 1～1000kg;
Solubilizing agent weight proportion scope: Tween 80: 1-99%, polysorbas20: 1-99%, polysorbate40: 1-99%, polysorbate60: 1-99% adds up to 100%;
Antiseptic weight proportion scope: sodium benzoate 1-99%, Potassium Benzoate 1-99%, sorbic acid 1-99%, dehydroacetic acid 1-99% add up to 100%;
Correctives weight proportion scope: sucrose 0.1-100kg, glucose 0.1-100kg, fructose 0.1-100kg, liquid glucose 1-99%.
2. preparation of drug combination method according to claim 1, its method for making is characterised in that: get crude drug Herba Pogostemonis, Rhizoma Atractylodis, Poria, Rhizoma Alismatis, Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), Herba Plantaginis, Pericarpium Citri Reticulatae, stir-fry Massa Medicata Fermentata, through making only, concoct, prepare burden, extract, make with extra care, filter, concentrating processes such as preparation, fill, leak detection, packing promptly.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE102010015791A1 (en) * | 2010-04-20 | 2011-10-20 | Beiersdorf Ag | Drug combinations of magnolia bark extract and polyethoxylated compounds |
| CN102847106B (en) * | 2012-08-28 | 2013-10-30 | 赵爱良 | Navel-applied plaster for treating pediatric gastrointestinal cold and preparation method thereof |
| CN104189595A (en) * | 2014-09-16 | 2014-12-10 | 洪满 | Quick-acting traditional Chinese medicine for treating digestive canal infection |
| CN104815183A (en) * | 2015-05-27 | 2015-08-05 | 向美芹 | Preparation method of medicine for treating infantile infectious diarrhea |
| CN104857302A (en) * | 2015-05-27 | 2015-08-26 | 杨琳 | Medicine for treating infectious diarrhea of babies |
| CN105412786A (en) * | 2015-12-09 | 2016-03-23 | 济南昊泽环保科技有限公司 | Traditional Chinese medicine for treating upper heat and lower cold type diarrhoea accompanied with abdominal pain |
| CN105267846A (en) * | 2015-12-09 | 2016-01-27 | 济南昊泽环保科技有限公司 | Traditional Chinese medicine for treating heat-upper cold-lower type diarrhoea |
| WO2021050000A1 (en) * | 2019-09-12 | 2021-03-18 | Crop Protection (Singapore) Pte. Ltd. | Method of preparing patchouli extract |
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| CN1966022A (en) * | 2006-11-21 | 2007-05-23 | 吴梅春 | Chinese medicinal formulation for treating children's diarrhea and method for preparing same |
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| CN1966022A (en) * | 2006-11-21 | 2007-05-23 | 吴梅春 | Chinese medicinal formulation for treating children's diarrhea and method for preparing same |
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Address after: 130012 Changchun, Jilin City, the torch Road, No. 833 Patentee after: Changchun leiyunshang Pharmaceutical Co. Ltd. Address before: 130012 Changchun, Jilin City, the torch Road, No. 833 Patentee before: Changchun Yuanda Guoao Pharmaceutical Co., Ltd. |