CN105726986A - Production process of Dendrobium officinale fine powder - Google Patents
Production process of Dendrobium officinale fine powder Download PDFInfo
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- CN105726986A CN105726986A CN201610135745.8A CN201610135745A CN105726986A CN 105726986 A CN105726986 A CN 105726986A CN 201610135745 A CN201610135745 A CN 201610135745A CN 105726986 A CN105726986 A CN 105726986A
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- herba dendrobii
- fine powder
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- sterilizing
- dendrobium officinale
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
The invention discloses a production process of Dendrobium officinale fine powder, comprising the following steps: 1), rough crushing: cleaning and removing impurities, and screening with a 20-mesh screen; 2), sterilizing with moisture and heat: loading roughly crushed Dendrobium officinale into a sterilizing barrel at 121 DEG C for 20 min; 3), drying: spreading Dendrobium officinale sterilized with moisture and heat into a stainless steel tray, controlling thickness to 20-30 mm, placing in a sterilizing drying box at controlled temperature of 115 DEG C for 50 min, and controlling moisture <60%; 4), jet crushing: under compressed air pressure of 0.75-0.95 Mpa, grading wheel frequency of 50 HZ, screening with a 100-mesh screen, and mixing; 5), packaging: packaging with a powder packaging machine. The production process has the advantages that biological active ingredients are retained to a high degree, medicinal effect is high, medicine absorption rate is high, production resource cost is low, and this powder is easy to evenly absorb.
Description
Technical field
The present invention relates to field of health care products, be specifically related to a kind of Herba Dendrobii fine powder production technique.
Background technology
Herba Dendrobii, for the perennial herbaceous plant that grows nonparasitically upon another plant of the orchid family, is born in the rock that mountain region half is dark and damp
On, happiness warm and moist weather and the environment of half cloudy half light.As far back as 87 years Herba Dendrobii just by state
Family is classified as natural crude drugs emphasis second class protection endangered plants.Herba Dendrobii main component contains Herba Dendrobii
Polysaccharide, dendrobine, dendramine etc., have tonifying five ZANG-organs asthenia, defying age, drops " three-hypers ",
The effect of suppression tumor, for the Chinese crude drug that China is the famousst and precious.Among the people, Herba Dendrobii is praised
For " help Herba mesonae chinensis " and " giant panda " of medicine circle.In the road that one-tenth book is front in more than 1,000 years
Herba Dendrobii is classified as first of " China's nine big Herba mesonae chinensis " by family medical science classical " Taoist Scriptures "；Li Shi
Precious evaluate in Compendium of Material Medica Herba Dendrobii " reinforcing YIN-essence benefit essence, thick the intestines and stomach, never sufficient in benefit,
Flat gastric qi, long muscle, Fructus Alpiniae Oxyphyllae, except frightened, made light of one's life by commiting suicide and is prolonged life ".Some edges such as China Shanghai and Zhejiang
Haicheng City, especially in Hong Kong, Macao and Taiwan and south east asia, has been acknowledged as high-end health preserving product.Ferrum
Skin Herba Dendrobii can improve human body immunity, memory reinforcing, and insomnia also has good effect, mends
The five internal organs asthenia, defying age, suppress tumor, improve diabetic symptom, anti-hypoxia, to chemicotherapy
And night life, the excessive person of tobacco and wine have remarkable result.
Due to scarcity and the costliness of price of dendrobium officinale resource, the Herba Dendrobii on market
Very different, increasingly mature along with artificial cultivation technique, the problem of Herba Dendrobii scarcity of resources
Progressively have been resolved, but the most domestic extraction utilizing Herba Dendrobii so also exists with utilizing to appoint
Deficiency, as the highest in bioactive ingredients reserving degree, drug effect is relatively low, drug absorption rate is relatively low,
The resources of production, with relatively costly, are difficult to be absorbed uniformly.
Summary of the invention
The technical problem to be solved in the present invention be to provide a kind of bioactive ingredients reserving degree high,
Drug effect is higher, drug absorption rate is higher, the resources of production are relatively low with cost, is easily absorbed uniformly
Herba Dendrobii fine powder production technique.
For solving the problems referred to above, the present invention adopts the following technical scheme that
A kind of Herba Dendrobii fine powder production technique, comprises the following steps:
1) coarse pulverization: clean remove impurity, takes Herba Dendrobii and crosses 20 mesh sieves；
2) moist heat sterilization: the Herba Dendrobii after coarse pulverization is loaded in sterilizing bucket, temperature
121 DEG C, time 20min；
3) it is dried: the Herba Dendrobii after moist heat sterilization is put in rustless steel pallet and shakeouts,
THICKNESS CONTROL, at 20-30mm, puts into sterilizing-drying case, and temperature controls to be dried at 115 DEG C
50min, controls moisture ＜ 6%；
4) comminution by gas stream: compressed air pressure 0.75～0.95Mpa, grading wheel frequency 50HZ,
Cross 100 mesh sieves, mixing；
5) packaging: use powder packing machine packaging.
Further, in step 3) in, after being dried, it is close that material loads clean rustless steel
In envelope bucket, seal, weigh, do intermediate products inspection.
Further, in step 5) in, adjusting screw rod rotating speed controls loading amount precision；Specification 2.5g/
Bag, packaging speed 40-50 bag/min, every 20 minutes, take out 10 bag Weighting and Controlling minus deviation≤
9%.
During micronizing, through controlling to produce superheating phenomenon, and it is fast to pulverize speed,
Be conducive to retaining the bioactive ingredients of non-refractory and various nutritional labeling, thus improve medicine
Effect.On the other hand, because superfine grinding is to carry out in totally-enclosed non-dusting system, can be effective
Avoiding outside contamination, make the content of microorganisms of product and dust be controlled, superfine grinding is with reason
Do not destroy the internal structure of Chinese crude drug from the point of view of Lun, retain the matter of Herba Dendrobii, gas, gas dawn four five
Taste is deposited especially.
The dissolution rate of medicine and the specific grain surface of medicine amass Chengwang's ratio and specific surface area and grain
Footpath is inversely proportional to.Therefore, the particle diameter of medicine is the thinnest, then its specific surface area is the biggest, more contributes to medicine
The dissolution of thing effective ingredient.
Dendrobium candidum ultrafine powder is added the 80 DEG C of stirrings of 50 times of water, finds that aqueous solution moment becomes
Thickness.Stirring 10 minutes extremely without filtering after powder mass, detection filtrate polyoses content is
0.26%, after conversion, polysaccharide content of dendrobium candidum reaches 26%, higher than Hua Yunfen to Herba Dendrobii
The mensuration content 15.02% of medical material and the yellow civil rights mensuration content 22.7% to Herba Dendrobii medical material.
After Herba Dendrobii is processed into Herba Dendrobii fine powder, the property of medicine can be made to give full play to, in fall
The curative effect identical with the dosage of original prescription also can be obtained after the dosage of low original prescription.Therefore, iron sheet
Herba Dendrobii fine powder can reduce Chinese medicine production cost with saving Chinese medicaments resource, makes enterprise and user benefit.
Being not difficult to find out from many scientific papers delivered at present, the ball of fine powder Chinese medicine dissipates medicine dosage and can subtract
Arrive original 1/3 1 1/5 less.And medical material after micronizing, typically do not carry out decocting,
Leaching just can direct preparation.The most both effective ingredient state loss in production link can have been reduced,
The oxygen that utilizes improving medical material can reduce again the waste of resource, and therefore this technology is particularly suited for iron sheet
The pulverizing of the rare Chinese medicine of this kind of preciousness of Herba Dendrobii.Meanwhile, Herba Dendrobii fine powder is less due to granularity,
Mouthfeel can be improved be easy to take. additionally, in actual production process, if Herba Dendrobii uses
General mechanical activation comminution, is difficult to be processed into fine powder, and because it contains, fibre strength is relatively big and stone
Dry measure used in former times polysaccharide has special stickiness, in common mechanical crushing process, often obtains substantial amounts of chieftain,
Dendrobium polysaccharide is attached in pulverizer.Cause the waste of crude drug, according to superfine grinding, this
Class Chinese crude drug the most easily operates.
After Herba Dendrobii cell wall breaking, intracellular moisture is moved out, and makes micropartical surface present half
Moisture state, (or this is called microparticle people to form stable particle cluster between particle and particle
Each particle cluster comprises the Chinese medicine ingredients of same ratio.The physical arrangement of this particle cluster is with group
Point HLB value (hydrophilic, equilibrium valve), ductility, brokenness, moisture content, relative density etc.
Various combination and different interactions and different.This structure can make each effective ingredient of Chinese crude drug
Homogenization, makes various composition be absorbed by the body equably, and this can also strengthen the effect effect of medicine
Really.
The invention have the benefit that 1. are conducive to retaining bioactive ingredients, improve drug effect；
2. increase drug absorption rate, improve bioavailability；3. save resource, reduce production cost；
4. fine particles, even particle size distribution.
Detailed description of the invention
By make the architectural feature to the present invention and effect of being reached have further to understand with
Understanding, describes in detail in order to preferred embodiment, is described as follows:
A kind of Herba Dendrobii fine powder production technique, comprises the following steps:
1) coarse pulverization: clean remove impurity, takes Herba Dendrobii and crosses 20 mesh sieves；
2) moist heat sterilization: the Herba Dendrobii after coarse pulverization is loaded in sterilizing bucket, temperature
121 DEG C, time 20min；
3) it is dried: the Herba Dendrobii after moist heat sterilization is put in rustless steel pallet and shakeouts,
THICKNESS CONTROL, at 20-30mm, puts into sterilizing-drying case, and temperature controls to be dried at 115 DEG C
50min, controls moisture ＜ 6%；
4) comminution by gas stream: compressed air pressure 0.75～0.95Mpa, grading wheel frequency 50HZ,
Cross 100 mesh sieves, mixing；
5) packaging: use powder packing machine packaging.
Further, in step 3) in, after being dried, it is close that material loads clean rustless steel
In envelope bucket, seal, weigh, do intermediate products inspection.
Further, in step 5) in, adjusting screw rod rotating speed controls loading amount precision；Specification 2.5g/
Bag, packaging speed 40-50 bag/min, every 20 minutes, take out 10 bag Weighting and Controlling minus deviation≤
9%.
The invention have the benefit that 1. are conducive to retaining bioactive ingredients, improve drug effect；
2. increase drug absorption rate, improve bioavailability；3. save resource, reduce production cost；
4. fine particles, even particle size distribution.
The above, the only detailed description of the invention of the present invention, but be not the limit to the present invention
System, those skilled in the art, according to the basic thought of the present invention, can revise and improve, but only
Will be without departing from the basic thought of the present invention, the most within the scope of the present invention.
Claims (3)
1. a Herba Dendrobii fine powder production technique, it is characterised in that comprise the following steps:
1) coarse pulverization: clean remove impurity, takes Herba Dendrobii and crosses 20 mesh sieves；
2) moist heat sterilization: the Herba Dendrobii after coarse pulverization is loaded in sterilizing bucket, temperature
121 DEG C, time 20min；
3) it is dried: the Herba Dendrobii after moist heat sterilization is put in rustless steel pallet and shakeouts,
THICKNESS CONTROL, at 20-30mm, puts into sterilizing-drying case, and temperature controls to be dried at 115 DEG C
50min, controls moisture ＜ 6%；
4) comminution by gas stream: compressed air pressure 0.75～0.95Mpa, grading wheel frequency 50HZ,
Cross 100 mesh sieves, mixing；
5) packaging: use powder packing machine packaging.
2. Herba Dendrobii fine powder production technique as claimed in claim 1, it is characterised in that:
Step 3) in, after being dried, material loads clean rustless steel and seals in bucket, seals, claims
Amount, does intermediate products inspection.
3. Herba Dendrobii fine powder production technique as claimed in claim 2, it is characterised in that:
Step 5) in, adjusting screw rod rotating speed controls loading amount precision；Specification 2.5g/ bag, packaging speed
40-50 bag/min, every 20 minutes, takes out 10 bag Weighting and Controlling minus deviation≤9%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610135745.8A CN105726986A (en) | 2016-03-10 | 2016-03-10 | Production process of Dendrobium officinale fine powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610135745.8A CN105726986A (en) | 2016-03-10 | 2016-03-10 | Production process of Dendrobium officinale fine powder |
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| Publication Number | Publication Date |
|---|---|
| CN105726986A true CN105726986A (en) | 2016-07-06 |
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ID=56250376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610135745.8A Pending CN105726986A (en) | 2016-03-10 | 2016-03-10 | Production process of Dendrobium officinale fine powder |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107569606A (en) * | 2016-11-21 | 2018-01-12 | 广西大学 | A kind of fine grain processing method of dendrobium candidum |
| CN107596131A (en) * | 2017-10-26 | 2018-01-19 | 中国科学院沈阳应用生态研究所 | A kind of preparation method of conic gymnadenia tuber ultrafine powder |
| CN109717465A (en) * | 2019-03-21 | 2019-05-07 | 江南大学 | A kind of Tiepi Fengdou sweet potato noodles and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319364A (en) * | 2011-09-22 | 2012-01-18 | 澄思源生物科技（上海）有限公司 | Manufacturing method of dendrobium candidum wallex lindll pure powder tablets |
| CN102772672A (en) * | 2012-08-24 | 2012-11-14 | 西双版纳增靓生物科技有限公司 | Dendrobium candidum ganoderma lucidum capsule |
| CN103920013A (en) * | 2014-04-02 | 2014-07-16 | 浙江亚林生物科技股份有限公司 | Preparation method of dendrobium officinale ultramicro wall-broken powder |
| CN104435743A (en) * | 2014-06-10 | 2015-03-25 | 武义寿仙谷中药饮片有限公司 | Method for preparing dendrobium officinale super micropowder |
| CN105288215A (en) * | 2015-11-17 | 2016-02-03 | 安徽千方生物科技有限公司 | High-activity dendrobium officinale kimura et migo freeze-drying powder buccal tablets and preparation process thereof |
-
2016
- 2016-03-10 CN CN201610135745.8A patent/CN105726986A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319364A (en) * | 2011-09-22 | 2012-01-18 | 澄思源生物科技（上海）有限公司 | Manufacturing method of dendrobium candidum wallex lindll pure powder tablets |
| CN102772672A (en) * | 2012-08-24 | 2012-11-14 | 西双版纳增靓生物科技有限公司 | Dendrobium candidum ganoderma lucidum capsule |
| CN103920013A (en) * | 2014-04-02 | 2014-07-16 | 浙江亚林生物科技股份有限公司 | Preparation method of dendrobium officinale ultramicro wall-broken powder |
| CN104435743A (en) * | 2014-06-10 | 2015-03-25 | 武义寿仙谷中药饮片有限公司 | Method for preparing dendrobium officinale super micropowder |
| CN105288215A (en) * | 2015-11-17 | 2016-02-03 | 安徽千方生物科技有限公司 | High-activity dendrobium officinale kimura et migo freeze-drying powder buccal tablets and preparation process thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107569606A (en) * | 2016-11-21 | 2018-01-12 | 广西大学 | A kind of fine grain processing method of dendrobium candidum |
| CN107596131A (en) * | 2017-10-26 | 2018-01-19 | 中国科学院沈阳应用生态研究所 | A kind of preparation method of conic gymnadenia tuber ultrafine powder |
| CN109717465A (en) * | 2019-03-21 | 2019-05-07 | 江南大学 | A kind of Tiepi Fengdou sweet potato noodles and preparation method thereof |
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Application publication date: 20160706 |