CN102784306B - Traditional Chinese medicine composition and feed for treating piglet edema disease and preparation methods of traditional Chinese medicine composition and feed - Google Patents
Traditional Chinese medicine composition and feed for treating piglet edema disease and preparation methods of traditional Chinese medicine composition and feed Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition and a feed for treating a piglet edema disease and preparation methods of the traditional Chinese medicine composition and the feed. The traditional Chinese medicine composition comprises plantain seeds, akebia stem, leonurus, dendrobium, small red beans, grifola, Chinese wax gourd peels, alisma, cyrtomium rhizome, manyleaf paris rhizome, gymnema, dogwood, prepared rehmannia roots, wolfberries and snakegourd roots. The traditional Chinese medicine composition and the feed for treating the piglet edema disease have the advantages of high cure rate, rapid treatment effect, no toxicity and side effects, less proneness to residual medicine production and the like.
Description
Technical field
The present invention relates to the pig starter feed technical field, particularly a kind of feedstuff of being used for the treatment of baby pig edema and preparation method thereof that contains.
Background technology
Bowel oedema disease has another name called the Gaster Sus domestica intestinal edema, is to be caused a kind of acute sporadic disease of ablactational baby pig by the toxin of pathogenic Escherichia coli.The toxin produced by Escherichia coli causes.Take cephalledema, movement disorder, convulsions, to benumb and cut open the edema such as when inspection coat of the stomach, mesentery be feature.This disease is multiple is born in late fall in early spring, the temperature cataclysm, feedstuff is changed suddenly and while turning group, mainly betide the ablactation piglet, and with the growth of 5～15 days after weaning, piglet morbidity fast, in good condition is the most common especially.
Clinical symptoms is mainly sudden onset, and body temperature is not high, the quadruped locomotion obstacle, and rear quarters is unable, waves and ataxia; The sick pig had does circular motion or blindly disorderly punching, suddenly violent body wash-ahead; Various stimulations or while catching, the scream of touching, call hoarsely, falls down to the ground, and extremity are touched, the shape of seemingly swimming; The common face of sick pig, blepharoedema, severe one is extended down to face, cervical region, and it is fat that head becomes.Major lesions is edema, upper palpebra inferior, face, lower jaw part, the subcutaneous canescence bean jelly sample edema that is of head.Curved greatly, the pars cardiaca edema of stomach are the gel-shaped edema between the mucous layer of stomach and Musclar layer; Film and lymph node edema thereof between the colon intestinal, film bean jelly sample between whole intestinal, cut and have volume liquid to flow out, and the intestinal mucosa redness is even hemorrhage.
The medicine for the treatment of baby pig edema mostly is Western medicine as kanamycin sulfate injection liquid at present, although therapeutic effect is arranged, therapeutic effect is not obvious, and can only when finding symptom, just be treated, can not play the effect of prevention, and there is the problem of drug residue in antibiotics.
Summary of the invention
Technical problem to be solved by this invention is according to theory of Chinese medical science, take anti-inflammation, heart tonifying, removing toxic substances, diuresis is the Therapeutic Principle, a kind of novel Chinese medicine composition that is used for the treatment of baby pig edema and the feedstuff that contains the Chinese medicine composition composition are provided, adopt that the prevention of this Chinese medicine composition and feedstuff and treatment edema disease have that cure rate is high, instant effect, have no side effect, be difficult for causing the advantages such as drug residue.
In order to realize the foregoing invention purpose, the invention provides a kind of Chinese medicine composition that is used for the treatment of baby pig edema, described Chinese medicine composition comprises Semen Plantaginis, Caulis Akebiae, Herba Leonuri, Herba Dendrobii, Semen Ormosiae Hosiei, Polyporus, Exocarpium Benincasae, Rhizoma Alismatis, Rhizoma Osmundae, Rhizoma Paridis, Largeleaf Gymnema, Fructus Corni, Radix Rehmanniae Preparata, Fructus Lycii and Radix Trichosanthis.
The ratio of weight and number of each component in described Chinese medicine composition is: Semen Plantaginis 20-46 part, Caulis Akebiae 10-16 part, Herba Leonuri 18-23 part, Herba Dendrobii 15-20 part, Semen Ormosiae Hosiei 15-25 part, Polyporus 20-40 part, Exocarpium Benincasae 10-15 part, Rhizoma Alismatis 10-18 part, Rhizoma Osmundae 16-25 part, Rhizoma Paridis 8-16 part, Largeleaf Gymnema 8-14 part, Fructus Corni 15-20 part, Radix Rehmanniae Preparata 20-35 part, Fructus Lycii 15-23 part and Radix Trichosanthis 5-10 part.
The ratio of weight and number of each component in described Chinese medicine composition is preferably: Semen Plantaginis 30-40 part, Caulis Akebiae 12-16 part, Herba Leonuri 18-23 part, Herba Dendrobii 16-18 part, Semen Ormosiae Hosiei 18-20 part, Polyporus 23-35 part, Exocarpium Benincasae 12-14 part, Rhizoma Alismatis 12-16 part, Rhizoma Osmundae 18-22 part, Rhizoma Paridis 10-14 part, Largeleaf Gymnema 10-13 part, Fructus Corni 16-19 part, Radix Rehmanniae Preparata 25-30 part, Fructus Lycii 18-21 part and Radix Trichosanthis 6-9 part.
The ratio of weight and number of each component in described Chinese medicine composition can also be preferably: 8 parts of 35 parts of Semen Plantaginiss, 14 parts of Caulis Akebiaes, 20 parts of Herba Leonuris, 17 parts of Herba Dendrobiis, 19 parts of Semen Ormosiae Hosiei, 24 parts of Polyporus, 13 parts of Exocarpium Benincasaes, 15 parts of Rhizoma Alismatis, 20 parts of Rhizoma Osmundae, 12 parts of Rhizoma Paridis, 12 parts of Largeleaf Gymnema, 17 parts of Fructus Corni, 28 parts, Radix Rehmanniae Preparata, 19 parts of Fructus Lyciis and Radix Trichosanthis.
Also comprise the Radix Astragali and dried tuber in described Chinese medicine composition, the described Radix Astragali and the dried tuber ratio of weight and number in described Chinese medicine composition is: Radix Astragali 15-26 part and dried tuber 18-25 part; The described Radix Astragali and the dried tuber ratio of weight and number in described Chinese medicine composition is preferably 21 parts of 20 parts of the Radixs Astragali and dried tubers.
Also comprise Pericarpium Citri Reticulatae, Semen Euryales and Massa Medicata Fermentata in described Chinese medicine composition, described Pericarpium Citri Reticulatae, Semen Euryales and the Massa Medicata Fermentata ratio of weight and number in described Chinese medicine composition is: Pericarpium Citri Reticulatae 2-5 part, Semen Euryales 1-3 part and Massa Medicata Fermentata 2-5 part; Described Pericarpium Citri Reticulatae, Semen Euryales and the Massa Medicata Fermentata ratio of weight and number in described Chinese medicine composition is preferably: 3 parts of 4 parts of Pericarpium Citri Reticulataes, 2 parts of Semen Euryaless and Massa Medicata Fermentata.
In order to realize the foregoing invention purpose, the present invention also provides a kind of preparation method that is used for the treatment of the Chinese medicine composition of baby pig edema, and described preparation method comprises:
The first step, each component in described Chinese medicine composition is mixed in proportion, be ground into 200-300 purpose powder, add the water doubly with respect to mixture quality 3-5, soak after 30 minutes, at the temperature of 90-100 ℃, decoct 40 minutes-1.5 hours, decoction liquor is filtered, and obtains the first filtrate and filtering residue;
Second step, the filtering residue that the first step is obtained adds with respect to the first step mixture quality 2-4 water doubly, at the temperature of 90-100 ℃, decocts 40 minutes-1.5 hours, and decoction liquor is filtered, and obtains the second filtrate;
The 3rd step, merge the first filtrate and the second filtrate, obtains decoction liquor.
The present invention also provides a kind of and has contained above-mentioned any one and be used for the treatment of the feedstuff of baby pig edema Chinese medicine composition, described feedstuff comprises that feed vector and described Chinese medicine composition are as additive, and in described feedstuff, the ratio of weight and number of feed vector and Chinese medicine composition is 100 weight portions: the 2-6 weight portion; Be preferably 100 weight portions: 4 weight portions.
Described feed vector comprises Semen Maydis, bean cake, whey powder, spray-dried plasma protein, soybean phospholipid oil and Sal.
In described feed vector, the ratio of weight and number of each component is Semen Maydis 35-45 part, bean cake 25-38 part, whey powder 15-28 part, spray-dried plasma protein 5-12 part, soybean phospholipid oil 3-5 part and Sal 0.5-2 part.
In described feed vector, the ratio of weight and number of each component is preferably: 1 part of 42 parts of Semen Maydiss, 33 parts of bean cake, 18 parts of whey powders, 10 parts of spray-dried plasma protein, 4 parts of soybean phospholipid oil and Sal.
The preparation method of described feedstuff comprises:
The first step, each component in described Chinese medicine composition is mixed in proportion, be ground into 200 orders-300 purpose powder, add the water doubly with respect to mixture quality 3-5, soak after 30 minutes, at the temperature of 90-100 ℃, decoct 40 minutes-1.5 hours, decoction liquor is filtered, and obtains the first filtrate and filtering residue;
Second step, the filtering residue that the first step is obtained adds with respect to the first step mixture quality 2-4 water doubly, at the temperature of 90-100 ℃, decocts 40 minutes-1.5 hours, and decoction liquor is filtered, and obtains the second filtrate;
The 3rd step, merge the first filtrate and the second filtrate, and concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dry cream is put into to spray dryer dry, guarantee that inlet temperature is at 150-180 ℃, leaving air temp 50-65 ℃, be ground into the 350-450 order subsequently, obtains the Chinese medicine composition powder;
The 4th step, take the raw material of feed vector by ratio of weight and the number of copies, drops into pulverizer and pulverized, and grinding particle size is the 200-300 order, the Chinese medicine composition powder input mixer that the mixture after pulverizing and the 3rd step are obtained, mix homogeneously, the uniformity of mixing≤5%.
The 5th step, pour into after mix homogeneously in the granulating disc that is placed in heeling condition and carry out pelletize, and the rotating speed of granulating disc is 50 rev/mins, and preparation time is 15 minutes, the spherical particle feedstuff that to be prepared into diameter be 1 millimeter;
The 6th step, the spherical particle feedstuff that the 4th step is obtained, spread on the mesh-belt drier with the portable rustless steel guipure of multilamellar, heat drying 15 minutes, the import air temperature of heating is 140 ℃, the outlet air temperature is 70 ℃, obtains dry feed granules.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: Chinese medicine composition of the present invention has to baby pig edema that cure rate is high, instant effect, has no side effect, and is difficult for causing the advantage of the aspects such as drug residue; The forage feed piglet of using the present invention to contain Chinese medicine composition, reduce the sickness rate of piglet, and improved the fertility performance of piglet.
The specific embodiment
The invention provides a kind of Chinese medicine composition that is used for the treatment of baby pig edema, comprise Semen Plantaginis, Caulis Akebiae, Herba Leonuri, Herba Dendrobii, Semen Ormosiae Hosiei, Polyporus, Exocarpium Benincasae, Rhizoma Alismatis, Rhizoma Osmundae, Rhizoma Paridis, Largeleaf Gymnema, Fructus Corni, Radix Rehmanniae Preparata, Fructus Lycii and Radix Trichosanthis.
In side, Semen Plantaginis, Caulis Akebiae, Herba Leonuri inducing diuresis to remove edema, heat-clearing and toxic substances removing, Herba Dendrobii, Semen Ormosiae Hosiei strengthening the spleen promote the production of body fluid, invigorating spleen to remove dampness, Polyporus, Exocarpium Benincasae, Rhizoma Alismatis clearing away heat and promoting diuresis, Rhizoma Osmundae, Rhizoma Paridis, Indigo Naturalis have effect, Largeleaf Gymnema, Fructus Corni, Radix Rehmanniae Preparata, Fructus Lycii heart tonifying, the anti-inflammation of removing toxic substances, Radix Trichosanthis is rich in albumen, vitamin, promotes the piglet gastrointestinal function.
The pharmacology of described each component is as follows:
Semen Plantaginis: containing volume mucus, plantenolic acid (Planterolic acid), plantagoside (Plantaginin), plantenolic acid (Plantenolic acid), succinic acid (Succinic acid), adenine (Adenine or 6-Aminopurine), choline (Choline), catalpol (Catalpol), protein and various fatty acid (Palmic acid, stearic acid, arachidic acid, oleic acid, linoleic acid, linolenic acid etc.), contain acidic mucopolysaccharide plantasan (Plantasan) in mucus. still containing vitamin A, B1.Have obvious diuresis and eliminate the phlegm and antitussive effect, " property of medicine is fallen " carries it: can remove pathogenic wind toxic, and the liver affected by pathogenic wind heat, malicious wind dotting punch order, swelling pain is hidden from view, and the headache lacrimation, remove irritable feverish sensation of chest and heart.
Caulis Akebiae: bitter, be slightly cold.Enter heart channel, small intestine meridian, urinary bladder channel.Clearing away heart-fire, diuresis, the stimulating milk secretion of stimulating the menstrual flow.Cure mainly: for irritable feverish sensation in the chest, the sore throat pharyngalgia, dark coloured urine, five types of stranguria, edema, whole body spasm and pain, the amenorrhea breast is few." book on Chinese herbal medicine converge with speech ": Caulis Akebiae, sharp nine orifices, except hot and suffocating, lead small intestinal, controls stranguria with turbid discharge, Dings Jing Epilepsy mad behavior, for the heart and small intestinal are wanted agent.So control frightened agent, multiplex Caulis Akebiae, therefore frightened also strongly fragrant by the motive, the heart is strongly fragrant both logical, normal urination, Er Jing Epilepsy mad behavior disease also pacify." medicine justice ": Caulis Akebiae, lead retention of heat in the spleen and stomach descending, cure mainly that fire rushes down, diarrhea of heat type, cover as sharp small intestinal fire stagnation, row bladder water blockage, divide extreme misery, temper from real also.And the heart transferring pathogenic heat to the small intestine and disease of ZANG-organs is tied by internal organs, the dirty peace of internal organs general rule.All for frightened sick, the strongly fragrant and vexed person of drowsiness by the motive, straight thorough descending with this.Ancients cube, heart-fire is evil, with Caulis Akebiae, leads redly, and lung-fire be heresy, uses the Cortex Mori purging pathogenic fire of the lung, and good have profound meaning also.
Herba Leonuri: enter the heart, liver, urinary bladder channel.Effect: promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing.Treatment edema, dysuria.The treatment water stasis of blood is tied mutually, congestion obstacle bladder.Can treat sore and toxic, urticaria.Promoting blood flow to regulate menstruation, for amenorrhea due to stagnation of blood, dysmenorrhea, blockage of menstruation, prolonged lochia, the stagnant stomachache of the stasis of blood.Can be used for again traumatic injury.Effect to uterus: Herba Leonuri decoct, ethanol extract and leonurine have excitation to the isolated uterine of the many animals such as rabbit, cat.To cardiovascular effect: Herba Leonuri is dirty to guinea-pig heart, cause myocardial infarction and ischemia model with isoproterenol, can significantly increase coronary flow and reach decreased heart rate quite significantly. quiet notes motherwort formulation makes anesthetized dog obviously increase coronary flow, reduce coronary resistance, the effect of decreased heart rate and minimizing output and left ventricular work.Antiplatelet aggregation and antithrombotic form: in vitro tests proves, intact animal's platelet aggregation that Herba Leonuri and extract thereof have antagonism ADP to induce. in vivo test also proves that Herba Leonuri can significantly reduce total number of blood platelet and the interior platelet of alveolar wall blood capillary and the aggregation thereof in peripheral circulation. and Herba Leonuri has remarkable dissolution to rabbit pulmonary circulation red thrombus. and in addition, Herba Leonuri also has the effects such as cellular immunization of enhancing body.Other effect: Herba Leonuri alkalescence subcutaneous injection has central inhibitory action, and MLD is 0.4-0.6g/kg.Intravenous rabbit injection leonurine 1mg/kg, visible urine amount significantly increases.Leonurine can make Sanguis Leporis seu oryctolagi suspension generation haemolysis when higher concentration.Leonurine infusion tube dilution method 1:13-1:10, to achorion schoenleinii, Pilus Caprae seu Ovis sample sporidiole bacteria, epidermophyton rubrum, starlike nocadia all have inhibitory action.The dull and stereotyped paper disk method of Herba Leonuri decoct, have inhibitory action to escherichia coli, dysentery bacterium.
Herba Dendrobii: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.For cloudy impairment of body fluid, lose, the xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision." book on Chinese herbal medicine is newly organized ": Herba Dendrobii, sweet in the mouth, micro-hardship, cold nature is nontoxic.Unavailable bamboo dry measure used in former times, wooden dry measure used in former times, idle with it, Herba Dendrobii is frightened sedate, beneficial smart reinforcing YIN-essence, the outstanding power that can be good for the foot knee joint, be apt to the numbness disease, falls the fire of the deficiency of YIN, and distinguished service is arranged greatly.Wu's purgation doctor, quite like and use it, and the people all over the world did not still know and knew its function this life.The lid Dendrobium nobile, be born among the grotto of Fujian, Guangdong, the ground of grotto and even the moon, and the side of Fujian, Guangdong Zhiyang is also, grasps Yinyang with life, thus cold not for cold, and impractical heat can be fallen.Husband's asthenic fire, also, Xiang Huoyi mends fire, and should not rush down mutually.Dendrobium nobile is wonderful is cold medicine, and benefit is arranged, and its property is descending again, and not up.If fire easily rises mutually, and is difficult for the person of falling also, obtain Herba Dendrobii and fall and do not rise.Between Xia Yue, the unable persons of two foots, take Herba Dendrobii strong, Isn't that descend and hold concurrently and mend the bright of Zhiyin and test.Therefore with Cortex Phellodendri, Rhizoma Anemarrhenae reducing the minister-fire person, how about with Dendrobium nobile for working as.Lid Cortex Phellodendri, the Rhizoma Anemarrhenae is of no help in rushing down, and the Dendrobium nobile invigorating middle warmer has and rushes down also.Or ask that the fire of the deficiency of YIN falls in Dendrobium nobile, be rush down the moon thing also, how can be good for the power of foot knee joint, wherein wonderful justice, not yet freely send out.
Semen Ormosiae Hosiei: sweet in the mouth, property is flat.The energy invigorating spleen to remove dampness, loose blood, removing toxic substances.Containing protein, fat, saccharide, phosphorus, calcium, ferrum, vitamin B1 .B2, the compositions such as nicotinic acid, Saponin.For edema, foot gas; Puerperal hypogalactia, diarrhoea, jaundice or dysuria; Hemorrhoid, acute appendicitis.Compendium of Material Medica: Semen Phaseoli, its property is descending, and logical small intestinal can enter cloudy minute, controls tangible disease.Therefore promoting circulation of body fluid, diuresis, relieving distension is except swollen, emesis and to control the inferior the dysentery intestinal out-of-the-way, and the disease of relieving the effect of alcohol, except the cold and heat carbuncle, the loose blood of evacuation of pus and promoting lactation, lower afterbirth dystocia, all tangible person of disease.Clothes fall order too for a long time, and body fluid oozes to be let out, so make the leanness heavy sensation of the body also.Its nasal insufflation Guadi San and ward off pestilence and use it, also get its ventilation dehumidifying heat radiation ear.
Polyporus: the diuresis swollen effect of harnessing the river is arranged.Containing polyporusum bellatus (glucan), test anticancer.Polyporus sweet in the mouth, light, flat, return kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen.Control dysuria, edema, have loose bowels, stranguria with turbid discharge, leukorrhagia.The effect that there is the diuresis antitumor and protect the liver.
Exocarpium Benincasae: sweet in the mouth; Cold nature.Return lung meridian; Spleen channel; Small intestine meridian.Function: clearing away heat and promoting diuresis; Detumescence.Cure mainly: edema; Dysuria; Have loose bowels; Skin ulcer is swollen.Control nephritis, dysuria, anasarca: Exocarpium Benincasae six money, Exocarpium Citrulli six money, Rhizoma Imperatae six money, Semen Maydis stamen four money, three liang of Semen Phaseolis.Decocting, three times sub-services on the one.
Rhizoma Alismatis: sweet in the mouth; Light; Cold in nature.Return kidney; Urinary bladder channel.Function cures mainly: promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.Main dysuria; The puckery pain of pyretic stranguria; The edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission.Amplification on Canon of Materia Medica: Rhizoma Alismatis, its merit is longer than capable water especially.Zhang Zhongjing is said, and it is thirsty tired that water holds, dysuria, or tell or rush down, WULING SAN master it.Side uses Rhizoma Alismatis, the old friend its with being longer than capable water." herbal classic " draws again Bian Que's cloud, takes patient's eyes puckery more, is really the row discharging the water pathogen.The person that Zhang Zhongjing eight flavor balls are used, also only draw and connect osmanthus, attached etc. returning with regard to kidney channel, without his meaning.Allly take the loose people of Rhizoma Alismatis, the not many persons of urine are not arranged; Urine is both many, and here must kidney qi answer real? how moderns' stopping leak essence, dare not use." detailed outline ": Rhizoma Alismatis, gas is flat, and sweet in the mouth is and light, and light can oozing let out, and abnormal smells from the patient is all thin, so diuretic and diarrhea.Taste have damp and hot, nose heave and blurred vision tinnitus, Rhizoma Alismatis is oozed it and wets, heat is also with going, and rustic must the order, clearing heat in QI system is up, weather is bright refreshing, therefore Rhizoma Alismatis has foster the five internal organs, physical strength profiting, controlling head revolves, the merit of clever knowledge, if clothes fall order too for a long time, clear QI failing to ascend, Kidney-Yin latent consumption, pacify to obtain blurred vision not? the Zhong Jing Dihuang Wan, use Poria, the Rhizoma Alismatis person, be to get the pathogen that it rushes down bladder, non-drawing connects also, ancients use tonic, must doublely rush down heresy, heresy goes that tonic is capable, one ward off one entire, this is mysterious, do not know this reason later age, single-minded in benefit, so for a long time clothes must to the evil of victory partially also.Legendary god of farming's book row Rhizoma Alismatis is in top grade, and duplicatus takes the light of making light of one's life by commiting suicide, look unfamiliar for a long time, and pottery, Soviet Union all think true, and stupid stealing doubted it.Rhizoma Alismatis row watery diarrhea kidney, for a long time clothes and can not, be equipped with again this siddhi, it is wrong known.
Rhizoma Osmundae: suffering, hardship, cold.Enter lung meridian.Heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing.For seasonal pathogen sense, partial heat person, heating is heavy, aversion to cold is light, it is red to have a headache, swallow, pharyngeal swelling, xerostomia and thirsty, red tongue, white and thin fur, floating pulse person.Anthelmintic action: dryopteris crassirhizoma, i.e. dryopteris crassirhizoma Nakai, root claims bracken, containing thick filicin (Filicin) 49.17%, can make european aspidium Dryopterisfilixmas(L.) succedaneum of Schott, drive away cestode.European aspidium can be benumbed cestode, and applicating history is very long.Domestic report, Rhizoma Osmundae is effective to the pig ascarid in vitro.Dryopteris crassirhizoma can also be driven away the Hepar Bovis seu Bubali trematodiasis.Its compound prescription decoctum has therapeutic efficiency to cattle fascioliasis and wealthy sucker trematodiasis.Antivirus action: the Shanghai report, Rhizoma Osmundae infected by influenza (the former PR8 strain of influenza virus type A of influenza, Asia A type virus) has the strong inhibition effect in the Embryo Gallus domesticus test, also effective in mice (nasal drip) test, but a little less than effect.This antivirus action relevant with its contained tannic acid (containing 14.5%).Shaanxi also reports, the A type of Rhizoma Osmundae infected by influenza (PR8), Asia A type (57-4), B-mode (Lee), the third type (1233), fourth type (celestial platform) all have inhibitory action.In the tissue culture with human embryo kidney (HEK) primary cell monolayer, also prove Rhizoma Osmundae to No. 479 adenovirus type IIIs, No. 72 poliomyelitis II types, liking for No. 44 can 9 type, COxsackie A9 type, coxsackie B 5 types, encephalitis B (Jing Wei grinds 1 strain), No. 140 seven kinds of representative Strain such as herpes simplex have stronger antivirus action.The water decoction of european aspidium also has the effect of anti-herpes simplex virus.Antibacterial action: Jiangxi, Hunan, Guangdong report, local Rhizoma Osmundae has some bacteriostasis, but effect is not strong, makes disinfection of drinking water or prevention epidemic cerebrospinal meningitis in rural area.It is said, to dermatophytes also some inhibitory action.Effect to uterus: decoct and refining after effective ingredient there is to significant excitation in the in vitro and uterus in place of rabbit, shrink and strengthen, tension force improves.The isolated uterine of dryopteris crassirhizoma injection in Guinea-pigs (0.1-0.7ml, every milliliter of suitable crude drug 50mg), rabbit (0.8-1.3ml) has significant excitation, and motion frequency and tensity all increase, and amplitude reduces, and heavy dose presents the contraction of tetanic property; But, after changing clothes, still can recover normal.The lunathyrium acrostichoidesChing Rhizoma Osmundae is very unobvious to the uterus effect.
Rhizoma Paridis: heat-clearing and toxic substances removing, antiasthmatic-antitussive, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc.Cure mainly: carbuncle, furuncle, scrofula, sore throat, chronic tracheitis, infantile convulsion is twitched, snake bite and insect sting." detailed outline ": the poison of snakeworm obtains stopping that this controls, therefore Rhizoma Paridis is arranged, sting and stop all names.Chong Tai, three layers, also lobate because of it.RHIZOMA PARIDIS, also flower-shaped because of it.Radix Kansui, because of its root shape also.Placenta Hominis, because of its function also.The Rhizoma Paridis gold thread, have it everywhere, is born in the ground that remote mountains is dark and damp.One stem is solely gone up, and stem is worked as the leaf heart, leaf green, and like Radix Paeoniae, all two, three layers, every one deck seven leaves.The stem head moon in summer blooms, and one spends seven lobes, and the spun gold stamen is arranged, long three, four cun, Wangwu Shan Mountain product person to five, seven layers.Root is as Rhizoma Dysosmae Versipellis, Rhizoma Atractylodis shape, white in outer purple, has sticky glutinous two kinds.Be used as medicine to wash and cut roasting use.
Largeleaf Gymnema: hardship, flat.Function cures mainly: heat-clearing and toxic substances removing, wind-expelling pain-stopping.For rheumatic arthritis, carbuncle furuncle and phyma poison, venom.The Gymnema sylvestre extract capsule tool removing heat from blood that dispels the wind, reducing swelling and alleviating pain, the effect of stomach invigorating diuresis.For anemofrigid-damp arthralgia, diabetes, vasculitis etc.In recent years, Chinese scholars research finds that it has the effects such as blood sugar lowering, dental caries and the reaction of inhibition sweet taste.Can also suppress to eat sweet food desire, suppress health to sugared absorption, reduce blood glucose, help to repair the pancreas damaged cell, improve the secretory volume of insulin.
Fructus Corni: sour, puckery, tepor.Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, and restrain astringent or styptic treatment for spontaneous sweating controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping and only collapse hidroschesis and also have in addition promoting the production of body fluid to quench thirst.Be used for soreness of waist and knee joint dizziness and tinnitus, forgetful emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses menoxenia, profuse sweating collapse.Interior-heat is quenched one's thirst.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.The yin nourishing of enriching blood, life essence-filling, marrow-benefitting." Bencao Congxin ": " kidney nourishing water, packing bone marrow, sharp blood vessels, tonification is Kidney-Yin, hearing-improing and eyesight improving, hair color crow palpus.Again can tonifying spleen-yin, only chronic diarrhea.Control the impairment caused by overstrain migratory arthralgia, cloudy losing generated heat, the dry cough phlegmatic cough, and dyspnea with shortness of breath, it is hungry that emptiness of the stomach is felt, and pox is demonstrate,proved the no pus of having a guilty conscience, and the shin thigh is ached after being ill, and the anxious pain of umbilicus abdomen in puerperal, feel card the moon and lose, lossless constipation, all kinds of moving blood, all hepatic and renal YIN deficiency, deficient all kinds of diseases and ailments, be the strengthening renal yin to inhibit predominant yang medicine.”
Fructus Lycii: modern study, Fructus Lycii has the blood glucose of reduction, lipotropy, and can atherosclerosis.Fructus Lycii is also strengthening the body resistance, and spermatogenesis is mended the good medicine of marrow, enriching yin and nourishing kidney, benefiting vital QI for tranquillizing, building body, slow down aging, evident in efficacy to chronic hepatitis, central serous chorioretinopathy, optic atrophy etc.; Diabetes, pulmonary tuberculosis etc. are also had to good therapeutic effect; To antitumor, protect the liver, the ageing disorders of blood pressure lowering, blood sugar lowering and old people's organ failure has very strong improvement effect.As tonic invigorator treatment suffer from a deficiency of the kidney each disease and the hepatorenal disease curative effect excellent, can significantly improve plasma testosterone cellulose content in human body, reach the effect of keeping fit.Modern medicine study shows, Fructus Lycii has obvious inhibitory action to cancer cell in vitro, the immunologic function that can be used for preventing the diffusion of cancerous cell and strengthen human body.
Radix Trichosanthis: sweet, micro-hardship is slightly cold.Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin." detailed outline ": radices trichosanthis, sweet and slightly bitter taste acid, acid can be promoted the production of body fluid, therefore the profit of quenching the thirst is withered, micro-bitter pathogenic fire reducing, sweetly do not injure one's stomach, the former times people only says its bitter cold, like deeply not examining." book on Chinese herbal medicine converge with speech ": Radix Trichosanthis, move back the five internal organs hot and suffocating, as heart-fire, to contain and dry tongue and mouth, lung-fire is contained and the pharyngeal swelling sore throat, and spleen-fire is contained and the dispute tooth is swollen, and phlegm-fire is contained and cough is not peaceful.If the swollen migratory arthralgia caused by wind of the side of body of liver-fire, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle burst and burst, and pyretic toxicity is loose, or five types of jaundice yellow skin and eye, and if if little water drenches puckeryly, be due to all burning hot pent-up, only this agent energy relieving stagnation, fall phlegm-fire, and can control it.Its property is sweet cold again, kindly can control yearningly, from tonic, controls empty yearningly, controls fire from the medicine of a cold nature thirsty, from the gas medicine, controls strongly fragrant yearningly, from the blood medicine, controls excessive thirst, is to control thirsty key medicine also.
Further preferably, the Chinese medicine composition that is used for the treatment of baby pig edema only consists of said components.
The ratio of weight and number of each component in Chinese medicine composition is: Semen Plantaginis 20-46 part, Caulis Akebiae 10-16 part, Herba Leonuri 18-23 part, Herba Dendrobii 15-20 part, Semen Ormosiae Hosiei 15-25 part, Polyporus 20-40 part, Exocarpium Benincasae 10-15 part, Rhizoma Alismatis 10-18 part, Rhizoma Osmundae 16-25 part, Rhizoma Paridis 8-16 part, Largeleaf Gymnema 8-14 part, Fructus Corni 15-20 part, Radix Rehmanniae Preparata 20-35 part, Fructus Lycii 15-23 part, Radix Trichosanthis 5-10 part.
The Chinese medicine composition that is used for the treatment of baby pig edema also comprises the Radix Astragali and dried tuber, and the Radix Astragali and the dried tuber ratio of weight and number in Chinese medicine composition is: Radix Astragali 15-26 part and dried tuber 18-25 part are preferably 21 parts of 20 parts of the Radixs Astragali and dried tubers.
The Radix Astragali: take tonify deficiency as main, energy invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.For insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst and do not hold back the person for a long time.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and immunologic function that can enhancing body, therefore can also be for preventing the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five ZANG-organs, control the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly sends out, and has antiperspirant to stop." be the good medicine of promoting resistance and defence disease.
Dried tuber: bitter in the mouth; Hot; Cool in nature.Gui Jing: liver; Lung meridian.Function cures mainly: activating QI to alleviate the depression; Dispelling wind for relieving itching; Wide born of the same parents' profit expectorant.Main uncomfortable in chest easypro; The rubella pruritus; Carbuncle is followed toxic swelling." Bencao Jingshu ": cyperi rhizoma, control married woman's metrorrhagia, leukorrhagia, menoxenia person, all sending down the abnormal ascending QI, regulating QI, eliminating stagnation, reason stagnant due to also, lid blood is not voluntarily, capable with gas, QI rising in reverse order and strongly fragrant, blood is also solidifying puckery, gas along blood also from and and smooth, this woman's bleeding not during menses, thus menses the uncomfortable salty palpus of disease ear.So must be aided with the medicine of beneficial blood removing heat from blood, deficiency of vital energy person is double, and to enter Qi-tonifying drug be to yield result also.
By adding this two kinds of auxiliary elements, play the effect of auxiliary treatment edema disease, the alleviating edemas disease symptoms.
The Chinese medicine composition that is used for the treatment of baby pig edema also comprises Pericarpium Citri Reticulatae, Semen Euryales and Massa Medicata Fermentata, Pericarpium Citri Reticulatae, Semen Euryales and the Massa Medicata Fermentata ratio of weight and number in Chinese medicine composition is: Pericarpium Citri Reticulatae 2-5 part, Semen Euryales 1-3 part and Massa Medicata Fermentata 2-5 part are preferably 4 parts of Pericarpium Citri Reticulataes, 2 parts of Semen Euryaless, 3 parts of Massa Medicata Fermentata.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, for diseases such as distension and fullness of the chest and abdomen.The hot loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, be longer than and regulate the flow of vital energy, can enter the spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gather around the diseases such as stagnant, chest and diaphragm feeling of fullness and stagnation of QI in spleen and stomach, distension and fullness in the abdomen for lung qi, for retention of dampness in middle-JIAO, gastral cavity abdomen painful abdominal mass is swollen, have loose bowels in loose stool, and the disease such as abundant expectoration cough.The Pericarpium Citri tangerinae dispelling the damp pathogen with bitter and warm drugs and can spleen invigorating circulation of qi promoting, therefore be usually used in the diseases such as retention of dampness in middle-JIAO, gastral cavity abdominal distention are vexed, loose stool greasy fur.Be good at again drying dampness to eliminate phlegm, stop up the key medicine commonly used of lung, abundant expectoration cough for controlling damp-phlegm, for insufficiency of the spleen diet reduce, dyspepsia, and the disease such as nausea and vomiting.This product dampness and can spleen benefiting and stimulating the appetite, be applicable to the diseases such as weakness of the spleen and stomach, diet minimizing, dyspepsia, loose stool and diarrhea.Can spleen invigorating because of it, can regulate the flow of vital energy again, therefore often make as the assistant of Qi-tonifying drug, can make tonify without causing stagnation, prevent from stopping up and hold back the swollen effect of doing, in addition, Pericarpium Citri tangerinae again can with in, can control stomach-QI being unable to descend normally, nausea and vomiting.
Semen Euryales: sweet puckery, flat.Enter the heart, kidney, spleen, stomach four warps.Invigorating the spleen and replenishing QI, for nourishing robustness food, a bit similar with Semen Nelumbinis, but the convergence controlling nocturnal emission with astringent drugs effect of Semen Euryales is stronger than Semen Nelumbinis, is applicable to chronic diarrhea and frequent micturition, emission, and the women is with many soreness of waist etc.
Massa Medicata Fermentata: for whole wheat flour and other drug (Herba Artemisiae Annuae, Herba Xanthii, the buds such as Herba polygoni hydropiperis, Semen Armeniacae Amarum, Semen Phaseoli) mix the processed goods formed by fermentation.Get Massa Medicata Fermentata and put in pot to fry to appearance and be coke black, inner coke yellow, take out, spray the water that disappears, cool, be Massa Medicata Fermentata (parched to brown).Massa Medicata Fermentata forms through fermentation, and the product of all fermentations have the digestant effect of strengthening the spleen and stomach, therefore, for bad, the feeling of stuffiness in chest abdominal distention of the digestion due to the diet internal injury, effect is quite arranged.
By adding this three kinds of auxiliary elements, promoting digestion and invigorating the stomach, promote digesting and assimilating of piglet
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how the application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition 1(toxicity test)
By Semen Plantaginis 70g, Caulis Akebiae 28 g, Herba Leonuri 40 g, Herba Dendrobii 34 g, Semen Ormosiae Hosiei 38 g, Polyporus 48g, Exocarpium Benincasae 26g, Rhizoma Alismatis 30g, Rhizoma Osmundae 40 g, Rhizoma Paridis 24 g, Largeleaf Gymnema 24 g, Fructus Corni 34 g, Radix Rehmanniae Preparata 56 g, Fructus Lycii 38 g, Radix Trichosanthis 16 g, the Radix Astragali 40 g, dried tuber 42 g, Pericarpium Citri Reticulatae 8g, Semen Euryales 4g, Massa Medicata Fermentata 6g mixes, be ground into 200 purpose powder, the water that adds 1884g, soak after 30 minutes, at the temperature of 100 ℃, decoct 1 hour, decoction liquor is filtered, obtain the first filtrate and filtering residue, the water that the filtering residue of acquisition is added to 1300g, at the temperature of 100 ℃, decoct 50 minutes, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are merged, obtain decoction liquor 1.
Select 60 of SD rats, divide three groups, every group 20, give the decocting liquid 1 of the Chinese medicine composition of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, after the last administration, 24 hours each groups were lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, and after administration, the index checkings such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology are carried out in 90 days and drug withdrawal in 2 weeks.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain all change without abnormal; Three dosage groups and matched group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range, between group without significant difference; Each is organized the main organs histopathological examination and shows no obvious abnormalities.The These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention, in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, rat is had no significant effect, without clear and definite toxicity target organ and sensitive indicator, the convalescent period observation also has no the retardance toxic reaction, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.
Embodiment 2 Chinese medicine compositions 2
By Semen Plantaginis 56 g, Caulis Akebiae 22 g, Herba Leonuri 38g, Herba Dendrobii 38 g, Semen Ormosiae Hosiei 32g, Polyporus 42 g, Exocarpium Benincasae 22 g, Rhizoma Alismatis 34 g, Rhizoma Osmundae 46 g, Rhizoma Paridis 30 g, Largeleaf Gymnema 18 g, Fructus Corni 36g, Radix Rehmanniae Preparata 46 g, Fructus Lycii 40 g, Radix Trichosanthis 14 g, Pericarpium Citri Reticulatae 6 g, Semen Euryales 4 g, Massa Medicata Fermentata 8g mixes, be ground into 300 purpose powder, the water that adds 1836g, soak after 30 minutes, at the temperature of 95 ℃, decoct 1.5 hours, decoction liquor is filtered, obtain the first filtrate and filtering residue, the water that the filtering residue of acquisition is added to 1270g, at the temperature of 100 ℃, decoct 1 hour, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are merged, obtain decoction liquor 2.
Embodiment 3 Chinese medicine compositions 3
By Semen Plantaginis 42g, Caulis Akebiae 30 g, Herba Leonuri 40g, Herba Dendrobii 32 g, Semen Ormosiae Hosiei 46g, Polyporus 60 g, Exocarpium Benincasae 20 g, Rhizoma Alismatis 24 g, Rhizoma Osmundae 32 g, Rhizoma Paridis 28 g, Largeleaf Gymnema 20g, Fructus Corni 32g, Radix Rehmanniae Preparata 30g, Fructus Lycii 32 g, Radix Trichosanthis 12g, the Radix Astragali 32 g, dried tuber 48 g mix, be ground into 300 purpose powder, the water that adds 1680g, soak after 30 minutes, at the temperature of 95 ℃, decoct 1.5 hours, decoction liquor is filtered, obtain the first filtrate and filtering residue, the water that the filtering residue of acquisition is added to 1680g, at the temperature of 100 ℃, decoct 1 hour, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are merged, obtain decoction liquor 3.
Embodiment 4 Chinese medicine compositions 4
By Semen Plantaginis 60 g, Caulis Akebiae 26 g, Herba Leonuri 41g, Herba Dendrobii 35 g, Semen Ormosiae Hosiei 40g, Polyporus 60 g, Exocarpium Benincasae 25 g, Rhizoma Alismatis 28 g, Rhizoma Osmundae 41 g, Rhizoma Paridis 24 g, Largeleaf Gymnema 22 g, Fructus Corni 35g, Radix Rehmanniae Preparata 55 g, Fructus Lycii 38g, Radix Trichosanthis 15 g mix, be ground into 260 purpose powder, the water that adds 2180g, soak after 30 minutes, at the temperature of 90 ℃, decoct 1.2 hours, decoction liquor is filtered, obtain the first filtrate and filtering residue, the water that the filtering residue of acquisition is added to 1635g, at the temperature of 100 ℃, decoct 1 hour, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are merged, obtain decoction liquor 4.
Embodiment 5 feedstuffs 1
Semen Plantaginis 44 g, Caulis Akebiae 30g, Herba Leonuri 44g, Herba Dendrobii 32g, Semen Ormosiae Hosiei 46g, Polyporus 54g, Exocarpium Benincasae 24 g, Rhizoma Alismatis 22g, Rhizoma Osmundae 34 g, Rhizoma Paridis 18g, Largeleaf Gymnema 22g, Fructus Corni 30g, Radix Rehmanniae Preparata 64 g, Fructus Lycii 32g, Radix Trichosanthis 10g, Radix Astragali 36g, dried tuber 40g, Pericarpium Citri Reticulatae 4g, Semen Euryales 4g, Massa Medicata Fermentata 4g are mixed, be ground into 300 purpose powder, add 2970g water, soak after 30 minutes, at the temperature of 95 ℃, decoct 1.5 hours, decoction liquor is filtered, and obtains the first filtrate and filtering residue; Filtering residue is added to 1782g water, at the temperature of 100 ℃, decoct 55 minutes, decoction liquor is filtered, and obtains the second filtrate; The first filtrate and the second filtrate are merged, and concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into to spray dryer dry, guarantees that inlet temperature is at 160 ℃, and 55 ℃ of leaving air temps, be ground into 350 orders subsequently, obtains the Chinese medicine composition powder; Semen Maydis 5775g, bean cake 4537.5g, whey powder 2475g, spray-dried plasma protein 1375 g, soybean phospholipid oil 550g and Sal 137.5g are mixed, dropping into pulverizer is pulverized, grinding particle size is 200 orders, the Chinese medicine composition powder input mixer that mixture after pulverizing and the 3rd step are obtained, mix homogeneously, the uniformity of mixing≤5%; Pour into after mix homogeneously in the granulating disc that is placed in heeling condition and carry out pelletize, the rotating speed of granulating disc is 50 rev/mins, and preparation time is 15 minutes, the spherical particle feedstuff that to be prepared into diameter be 1 millimeter; The spherical particle feedstuff that the 4th step obtains, spread on the mesh-belt drier with the portable rustless steel guipure of multilamellar, heat drying 15 minutes, and the import air temperature of heating is 140 ℃, the outlet air temperature is 70 ℃, obtains dry feed granules.
Embodiment 6 feedstuffs 2
Semen Plantaginis 44 g, Caulis Akebiae 30g, Herba Leonuri 44g, Herba Dendrobii 32g, Semen Ormosiae Hosiei 46g, Polyporus 54g, Exocarpium Benincasae 24 g, Rhizoma Alismatis 22g, Rhizoma Osmundae 34 g, Rhizoma Paridis 18g, Largeleaf Gymnema 22g, Fructus Corni 30g, Radix Rehmanniae Preparata 64 g, Fructus Lycii 32g, Radix Trichosanthis 10g, Radix Astragali 36g, dried tuber 40g are mixed, be ground into 300 purpose powder, add 2328g water, soak after 30 minutes, at the temperature of 95 ℃, decoct 1 hour, decoction liquor is filtered, and obtains the first filtrate and filtering residue; Filtering residue is added to 2328g water, at the temperature of 100 ℃, decoct 65 minutes, decoction liquor is filtered, and obtains the second filtrate; The first filtrate and the second filtrate are merged, and concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into to spray dryer dry, guarantees that inlet temperature is at 170 ℃, and 60 ℃ of leaving air temps, be ground into 400 orders subsequently, obtains the Chinese medicine composition powder; Semen Maydis 7365.6g, bean cake 5319.6g, whey powder 4705.8g, spray-dried plasma protein 1227.6g, soybean phospholipid oil 613.8g and Sal 163.7g are mixed, dropping into pulverizer is pulverized, grinding particle size is 200 orders, the Chinese medicine composition powder input mixer that mixture after pulverizing and the 3rd step are obtained, mix homogeneously, the uniformity of mixing≤5%; Pour into after mix homogeneously in the granulating disc that is placed in heeling condition and carry out pelletize, the rotating speed of granulating disc is 50 rev/mins, and preparation time is 15 minutes, the spherical particle feedstuff that to be prepared into diameter be 1 millimeter; The spherical particle feedstuff that the 4th step obtains, spread on the mesh-belt drier with the portable rustless steel guipure of multilamellar, heat drying 15 minutes, and the import air temperature of heating is 140 ℃, the outlet air temperature is 70 ℃, obtains dry feed granules.
Embodiment 7 feedstuffs 3
Semen Plantaginis 44 g, Caulis Akebiae 30g, Herba Leonuri 44g, Herba Dendrobii 32g, Semen Ormosiae Hosiei 46g, Polyporus 54g, Exocarpium Benincasae 24 g, Rhizoma Alismatis 22g, Rhizoma Osmundae 34 g, Rhizoma Paridis 18g, Largeleaf Gymnema 22g, Fructus Corni 30g, Radix Rehmanniae Preparata 64 g, Fructus Lycii 32g, Radix Trichosanthis 10g, Radix Astragali 36g, dried tuber 40g, Pericarpium Citri Reticulatae 4g, Semen Euryales 4g, Massa Medicata Fermentata 4g are mixed, be ground into 300 purpose powder, add 1554g water, soak after 30 minutes, at the temperature of 90 ℃, decoct 40 minutes, decoction liquor is filtered, and obtains the first filtrate and filtering residue; Filtering residue is added to 2072g water, at the temperature of 100 ℃, decoct 50 minutes, decoction liquor is filtered, and obtains the second filtrate; The first filtrate and the second filtrate are merged, and concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into to spray dryer dry, guarantees that inlet temperature is at 160 ℃, and 60 ℃ of leaving air temps, be ground into 400 orders subsequently, obtains the Chinese medicine composition powder; Semen Maydis 4199g, bean cake 3867.5g, whey powder 2210g, spray-dried plasma protein 884g, soybean phospholipid oil 552.5g and Sal 165.8g are mixed, dropping into pulverizer is pulverized, grinding particle size is 200 orders, the Chinese medicine composition powder input mixer that mixture after pulverizing and the 3rd step are obtained, mix homogeneously, the uniformity of mixing≤5%; Pour into after mix homogeneously in the granulating disc that is placed in heeling condition and carry out pelletize, the rotating speed of granulating disc is 50 rev/mins, and preparation time is 15 minutes, the spherical particle feedstuff that to be prepared into diameter be 1 millimeter; The spherical particle feedstuff that the 4th step obtains, spread on the mesh-belt drier with the portable rustless steel guipure of multilamellar, heat drying 15 minutes, and the import air temperature of heating is 140 ℃, the outlet air temperature is 70 ℃, obtains dry feed granules.
Semen Maydis 35-45 part, bean cake 25-38 part, whey powder 15-28 part, spray-dried plasma protein 5-12 part, soybean phospholipid oil 3-5 part and Sal 0.5-2 part.
0.8 part of 36 parts of Semen Maydiss, 26 parts of bean cake, 23 parts of whey powders, 6 parts of spray-dried plasma protein, 3 parts of soybean phospholipid oil and Sal.
Embodiment 8 contrast test 1(traditional Chinese medicine composition for treating Contrast on effects)
Experimental animal
Choose 300 of piglets that suffer from edema disease, the piglet cephalledema, movement disorder, be baby pig edema through clinical definite.
Test method
400 ill piglets are divided into to 5 groups at random, 80 every group.The Chinese medicine composition decoction liquor 1-4 that treatment group 1-3 adopts respectively embodiment of the present invention 1-4 to prepare is as medicine (treatment group 1-4), for oral administration, the morning, noon and afternoon each once, each 300ml; Matched group adopts intramuscular injection kanamycin sulfate injection liquid, every 300,000 IU.Therapeutic outcome is as shown in table 1.
Table 1 therapeutic outcome synopsis
From the data of table 1, the Chinese medicine composition that adopts embodiment of the present invention 1-4 to the baby pig edema cure rate apparently higher than matched group.
Embodiment 9 contrast test 2(feedstuff prevention effect contrasts)
Select six and group's Xiajin pig breeding farm base be test site, choose at random 480 of weanling piglets of health that average weight is about about 12kg as test pig, statistical analysis body weight difference is not remarkable.Be divided at random four groups, every group of 120 piglets, be respectively test group 1, test group 2, test group 3 and matched group; Wherein, test group 1 selects the feedstuff 1 of embodiment 5 to feed, and test group 2 selects the feedstuff 2 of embodiment 6 to feed, and test group 3 selects the feedstuff 3 of embodiment 7 to feed, and matched group selects traditional pig feed to feed.
Test pig free choice feeding and drinking-water, carry out immunity and anthelmintic routinely, and observe and record the pig mental status of state of an illness condition and pig of swelling that floods every day in experimental period.Totally 30 days experimental period,, take body weight during off-test, calculate daily gain, daily ingestion amount, meat feed ratio and the sickness rate of every group, and result is as shown in table 2.
Table 2 feedstuff prevention effect synopsis
Data from table 2, with traditional pig feed, compare, use the piglet of forage feed in weaning period of embodiment of the present invention 5-7, not only can improve daily gain and the feed intake of piglet, and obviously reduced the sickness rate of baby pig edema, show that feedstuff of the present invention is specially adapted to feed piglet.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (7)
1. the Chinese medicine composition that is used for the treatment of baby pig edema, it is characterized in that, the ratio of weight and number of each component in described Chinese medicine composition is: Semen Plantaginis 20-46 part, Caulis Akebiae 10-16 part, Herba Leonuri 18-23 part, Herba Dendrobii 15-20 part, Semen Ormosiae Hosiei 15-25 part, Polyporus 20-40 part, Exocarpium Benincasae 10-15 part, Rhizoma Alismatis 10-18 part, Rhizoma Osmundae 16-25 part, Rhizoma Paridis 8-16 part, Largeleaf Gymnema 8-14 part, Fructus Corni 15-20 part, Radix Rehmanniae Preparata 20-35 part, Fructus Lycii 15-23 part, Radix Trichosanthis 5-10 part, Radix Astragali 15-26 part, dried tuber 18-25 part, Pericarpium Citri Reticulatae 2-5 part, Semen Euryales 1-3 part and Massa Medicata Fermentata 2-5 part.
2. the Chinese medicine composition that is used for the treatment of baby pig edema according to claim 1, it is characterized in that, the ratio of weight and number of each component in described Chinese medicine composition is: Semen Plantaginis 30-40 part, Caulis Akebiae 12-16 part, Herba Leonuri 18-23 part, Herba Dendrobii 16-18 part, Semen Ormosiae Hosiei 18-20 part, Polyporus 23-35 part, Exocarpium Benincasae 12-14 part, Rhizoma Alismatis 12-16 part, Rhizoma Osmundae 18-22 part, Rhizoma Paridis 10-14 part, Largeleaf Gymnema 10-13 part, Fructus Corni 16-19 part, Radix Rehmanniae Preparata 25-30 part, Fructus Lycii 18-21 part, Radix Trichosanthis 6-9 part, Radix Astragali 15-26 part, dried tuber 18-25 part, Pericarpium Citri Reticulatae 2-5 part, Semen Euryales 1-3 part and Massa Medicata Fermentata 2-5 part.
3. the preparation method that is used for the treatment of the Chinese medicine composition of baby pig edema according to claim 1 and 2, is characterized in that, described preparation method comprises:
The first step, each component in described Chinese medicine composition is mixed in proportion, be ground into 200 orders-300 purpose powder, add the water doubly with respect to mixture quality 3-5, soak after 30 minutes, at the temperature of 90-100 ℃, decoct 40 minutes-1.5 hours, decoction liquor is filtered, and obtains the first filtrate and filtering residue;
Second step, the filtering residue that the first step is obtained adds with respect to the first step mixture quality 2-4 water doubly, at the temperature of 90-100 ℃, decocts 40 minutes-1.5 hours, and decoction liquor is filtered, and obtains the second filtrate;
The 3rd step, merge the first filtrate and the second filtrate, obtains decoction liquor.
4. a feedstuff that comprises claim 1 or 2 described Chinese medicine composition, it is characterized in that, described feedstuff comprises that feed vector and described Chinese medicine composition are as additive, and in described feedstuff, the ratio of weight and number of feed vector and Chinese medicine composition is 100 weight portions: the 2-6 weight portion.
5. feedstuff according to claim 4, is characterized in that, described feed vector comprises Semen Maydis, bean cake, whey powder, spray-dried plasma protein, soybean phospholipid oil and Sal.
6. feedstuff according to claim 5, it is characterized in that, in described feed vector, the ratio of weight and number of each component is Semen Maydis 35-45 part, bean cake 25-38 part, whey powder 15-28 part, spray-dried plasma protein 5-12 part, soybean phospholipid oil 3-5 part and Sal 0.5-2 part.
7. the preparation method of feedstuff according to claim 6, is characterized in that, described preparation method comprises:
The first step, each component in described Chinese medicine composition is mixed in proportion, be ground into 200 orders-300 purpose powder, add the water doubly with respect to mixture quality 3-5, soak after 30 minutes, at the temperature of 90-100 ℃, decoct 40 minutes-1.5 hours, decoction liquor is filtered, and obtains the first filtrate and filtering residue;
Second step, the filtering residue that the first step is obtained adds with respect to the first step mixture quality 2-4 water doubly, at the temperature of 90-100 ℃, decocts 40 minutes-1.5 hours, and decoction liquor is filtered, and obtains the second filtrate;
The 3rd step, merge the first filtrate and the second filtrate, and concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dry cream is put into to spray dryer dry, guarantee that inlet temperature is at 150-180 ℃, leaving air temp 50-65 ℃, be ground into the 350-450 order subsequently, obtains the Chinese medicine composition powder;
The 4th step, take the raw material of feed vector by ratio of weight and the number of copies, drops into pulverizer and pulverized, and grinding particle size is the 200-300 order, the Chinese medicine composition powder input mixer that the mixture after pulverizing and the 3rd step are obtained, mix homogeneously, the uniformity of mixing≤5%;
The 5th step, pour into after mix homogeneously in the granulating disc that is placed in heeling condition and carry out pelletize, and the rotating speed of granulating disc is 50 rev/mins, and preparation time is 15 minutes, the spherical particle feedstuff that to be prepared into diameter be 1 millimeter;
The 6th step, the spherical particle feedstuff that the 5th step is obtained, spread on the mesh-belt drier with the portable rustless steel guipure of multilamellar, heat drying 15 minutes, the import air temperature of heating is 140 ℃, the outlet air temperature is 70 ℃, obtains dry feed granules.
Priority Applications (1)
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| CN103212007B (en) * | 2013-04-28 | 2015-04-15 | 赵道全 | Traditional Chinese medicine preparation for treating abdominal distension of giant salamanders and preparation method of preparation |
| CN103652361B (en) * | 2013-12-23 | 2015-03-25 | 山东新希望六和集团有限公司 | Feed for postpartum sow in lactation period of 1-20 days and preparation method thereof |
| CN103931953B (en) * | 2014-05-09 | 2015-08-12 | 山东新希望六和集团有限公司 | A kind of feed, Chinese medicine composition and preparation method for preventing and treating bowel oedema disease |
| CN105641260A (en) * | 2014-11-11 | 2016-06-08 | 天津中敖生物科技有限公司 | Traditional Chinese medicinal composition for treating piglet edema disease and preparation method of traditional Chinese medicinal composition |
| CN104383188A (en) * | 2014-11-27 | 2015-03-04 | 山东新希望六和集团有限公司 | Pharmaceutical composition for preventing and treating piglet edema diseases and preparation method of pharmaceutical composition |
| CN104489296A (en) * | 2014-11-27 | 2015-04-08 | 山东新希望六和集团有限公司 | Functional feed for preventing piglet oedema disease, and preparation method thereof |
| CN105285417A (en) * | 2015-12-04 | 2016-02-03 | 山东新希望六和集团有限公司 | Formula feed for piglets and preparation method thereof |
| CN105285419A (en) * | 2015-12-04 | 2016-02-03 | 山东新希望六和集团有限公司 | Formula feed for swine and preparation method thereof |
| CN105412409A (en) * | 2015-12-14 | 2016-03-23 | 刘朝全 | Drug for preventing and treating piglet edema disease and preparation method of drug |
| CN107648398A (en) * | 2017-11-03 | 2018-02-02 | 天津瑞贝特科技发展有限公司 | Treat the Chinese medicine composition of escherichia coli of piglets type stomach and intestine oedema |
| CN107929533B (en) * | 2017-12-14 | 2021-06-01 | 四川农业大学 | Traditional Chinese medicine granules and feed for promoting growth performance of adult fattening pigs and preparation method thereof |
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