CN104352606A - Preparation for treating esophagus cancer in mode of combating poison with poison and preparation method of preparation - Google Patents

Abstract

The invention discloses a preparation for treating esophagus cancer in a mode of combating poison with poison. The preparation is prepared from the following raw material medicines in parts by weight: 9-15 parts of scorpio, 10-20 parts of silkworm larva, 8-16 parts of Brucea javanica, 6-15 parts of thunder god vine, 8-12 parts of Patrinia heterophylla, 10-20 parts of concha arcae, 3-6 parts of Chinese blister beetle, 2-5 parts of venenum bufonis, 3-5 parts of catharanthus roseus, 4-6 parts of pillworm, 3-6 parts of short-pedicel aconite root, 9-15 parts of oldenlandia diffusa and 8-12 parts of drumfish swimming bladder. The preparation disclosed by the invention has the excellent effects that the preparation is mainly a pure traditional Chinese medicine preparation, and the medicines directly act on cancer tissues, so that the active ingredients of the medicines can rapidly reach the focus, the availability of the medicine is improved, the cancer cells can be effectively killed, growth of the cancer cells is inhibited, cancer cell diffusion is avoided, and the effect of inhibiting tumor cell growth and transfer is achieved. The obtained product has the effects of dredging the esophagus, calming the adverse-rising energy and preventing or arresting vomiting, reducing phlegm and detoxifying, relieving pain, inhibiting cancer and resisting cancer, enhancing the immunity and prolonging the life and is mainly used for the esophagus cancer.

Description

The preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma and preparation method

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to preparation and the preparation method of a kind for the treatment of the poisonous disease with poisonous drugs treatment esophageal carcinoma.

Background technology

The esophageal carcinoma is common digestive tract tumor, and the whole world about has 300,000 people to die from the esophageal carcinoma every year.Its M & M various countries are widely different.China is one of Esophageal Cancer area in the world, and every annual is died of illness about 150,000 people.Man is more than female, and age of onset is many more than 40 years old.The typical symptom of the esophageal carcinoma is Progressive symmetric erythrokeratodermia acataposis, before this food of difficult dry pharynx, is semiliquid diet then, and last water and saliva can not be swallowed.

The esophageal carcinoma belongs to the categories such as " dysphagic " " regurgitation " in the traditional Chinese medical science, and i.e. dysphagia of choking, namely swallows and have some setbacks; Diaphragm is that lattice are refused, and refers to inappetence.Choke and can occur separately, the Late manifestations that diaphragm is choked often, therefore usually dysphagic and claim.The name of disease of diaphragm sees in Huangdi's Internal Classics the earliest, and " Plain Questions negative and positive another matter " is said: " the diaphragm of three constipation caused by accumulation of heat meanings." " Plain Questions the most pure virginity will be discussed greatly " say: " inappetence, diaphragm is choked obstructed, vomiting right after eating." " Plain Questions logical comments deficiency and excess opinion " say: " close absolutely every plug, obstructed up and down, then disease due to intense worry is also." dysphagic be the disease of deficiency in origin and excess in superficiality, basic pathogenesis is eating and drinking without temperance, feelings will internal injury, aged debility, causes gas, expectorant, congestion etc. to block esophagus.The traditional Chinese medical science is thought, is the card of deficiency in origin and excess in superficiality, should follows the principle of symptomatic treatment in acute condition although dysphagic, and patient hinders in esophagus because of gas, expectorant, congestion, and diet difficulty enters, and treats based on blood circulation promoting and blood stasis dispelling, promoting the circulation of QI and reducing phlegm, helps with strengthening the body resistance.Otherwise needing of wound of a specified duration, esophagus is obstructed, and diet difficulty enters, and the foundation of acquired constitution is difficult to supplement nutrition, no resource of generating and transforming QI and blood, and its this benefit is empty.The disease of dysphagic ability refractory, Indigo Naturalis meter south " objective dirt medical notes " is said: " drum diaphragm is the disease of refractory, and so drum is especially known, and diaphragm breaks uncurable disease, modernly instantly can not to enter, then qi of zang-fu viscera knot exhausts, therefore sees that this is sick, less can Na Gu, dead within a year; Complete not Na Gu, does not go out half a year and dead." dysphagic be disease, the source of absolutely life, vicious cycle, progress is rapid.Chinese traditional treatment is emphasized blood circulation promoting and blood stasis dispelling, promoting the circulation of QI and reducing phlegm.Yu Guiqing doctor adopts the main formula that the basis of the strongly fragrant miracle of two arts is added and subtracted.The wherein strongly fragrant miracle composition of two arts: the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Radix Curcumae, Radix Clematidis, Radix Salviae Miltiorrhizae.It is the Empirical formula of the treatment esophageal carcinoma.Doctor trained in Western medicine aspect, mainly adopts operative treatment for early stage patient, patients with terminal, and as physical condition is good, the feasible radiotherapy of the obvious person of obstruction or stent in the treatment, then in conjunction with treatment by Chinese herbs.

Authorize publication No. CN 101342360 B(application number 200810138889.4) Chinese invention patent document disclose a kind of Chinese medicine composition for the treatment of the esophageal carcinoma, be made up of the raw material of Chinese medicine of following weight ratio: Herba Solani Lyrati 19g, Herba Duchesneae Indicae 10g, Poria 7g, Pericarpium Citri Reticulatae 10g, Flos Inulae 10g, Herba Scutellariae Barbatae 20g, Herba Hedyotidis Diffusae 20g, Rhizoma Smilacis Chinensis 3g, Gekko Swinhonis 4g, Fructus Jujubae 20g, Rhizoma Zingiberis Recens 20g, Arisaema Cum Bile 10g, Haematitum 10g, Venenum Bufonis 3g, Radix Ginseng 10g, Rhizoma Pinelliae 10g.Authorize publication No. CN 101919967 B(application number 201010210200.1) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of the esophageal carcinoma, be made up of the raw material of Chinese medicine of following weight ratio: Pseudobulbus Cremastrae Seu Pleiones 10 parts-30 parts, Placenta Hominis 30 parts-50 parts, Radix Clematidis 30-50 part, Herba Scutellariae Barbatae 30-50 part, Flos Lonicerae 10-30 part, Scolopendra 1 part-10 parts, Scorpio 10 parts-30 parts, Pheretima 10 parts-30 parts, Radix Ginseng 30 parts-50 parts, Ganoderma 10 parts-30 parts, Radix Panacis Quinquefolii 30 parts-50 parts, Herba Pileae Scriptae 30 parts-50 parts, Radix Notoginseng 30 parts-50 parts, Sanguis Draxonis 10 parts-30 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 30 parts-50 parts, 10 parts-30 parts, Radix Glycyrrhizae.Authorize publication No. CN 102284034 A(application number 201010217471.X) Chinese invention patent document disclose a kind of Chinese medicine pill and compound method thereof for the treatment of the esophageal carcinoma, this formula is: Radix Angelicae Sinensis 5g, Rhizoma Chuanxiong 6g, Radix Rehmanniae 4g, Radix Paeoniae Alba 6g, Fructus Amomi 7g, Cortex Magnoliae Officinalis 8g, Radix Aucklandiae 9g, Semen Coicis 4g, Pericarpium Citri Reticulatae 5g, Rhizoma Smilacis Glabrae 4g, Pseudobulbus Cremastrae Seu Pleiones 6g, Carapax Eretmochelydis 5g, Radix Glycyrrhizae 4g.

At present for the treatment of primary disease, doctor trained in Western medicine mainly adopts the method for operation and Radiotherapy chemotherapy, and success rate of operation is lower, somewhat expensive, and chemotherapy easily causes patient's hypoimmunity, increases misery to patient.Chinese traditional treatment primary disease, has unique advantage, if thinking is correct, in order, combination has room, completely likely impels its " dawn of new hopes " in reply.

Summary of the invention

The object of the invention is, provide a kind for the treatment of the poisonous disease with poisonous drugs to treat the preparation of the esophageal carcinoma, make by adding the cooperation of a few herbs raw material, preparation method is simple, has good inhibitory action to tumor cell.

Technical scheme of the present invention is:

The preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma, is characterized in that: be prepared from by following bulk drugs, is weight portion: Scorpio 9-15, Bombyx Batryticatus 10-20, Fructus Bruceae 8-16, Radix Tripterygii Wilfordii 6-15, Radix Patriniae heterophyllae 8-12, Concha Arcae 10-20, Mylabris 3-6, Venenum Bufonis 2-5, Herba Catharanthi Rosei 3-5, Armadillidium 4-6, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 3-6, Herba Hedyotidis Diffusae 9-15, Shishou Air Bladder pseudosciaenae seu Acipenser 8-12.

In preferred scheme, Scorpio 11-13, Bombyx Batryticatus 14-16, Fructus Bruceae 10-14, Radix Tripterygii Wilfordii 8-13, Radix Patriniae heterophyllae 9-11, Concha Arcae 14-16, Mylabris 4-5, Venenum Bufonis 3-4, Herba Catharanthi Rosei 3.5-4.5, Armadillidium 4.5-5.5, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4-5, Herba Hedyotidis Diffusae 11-13, Shishou Air Bladder pseudosciaenae seu Acipenser 9-11.

Be more preferably, Scorpio 12, Bombyx Batryticatus 15, Fructus Bruceae 2, Radix Tripterygii Wilfordii 10.5, Radix Patriniae heterophyllae 10, Concha Arcae 15, Mylabris 4.5, Venenum Bufonis 3.5, Herba Catharanthi Rosei 4, Armadillidium 5, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4.5, Herba Hedyotidis Diffusae 12, Shishou Air Bladder pseudosciaenae seu Acipenser 10.

The preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma, be made into pharmaceutically acceptable pill, preparation method is:

(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 2-6 hour (preferred coddle 4 hours), taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) be placed in hermetic container by Mylabris, the sodium hydroxide solution adding 4-8 times amount volume soaks 6-12 hour (preferably soaking 9 hours), takes out Mylabris, drying, levigation, mixes with step (1) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder, Armadillidium powder and Fructus Bruceae powder, sieve, obtain mixing fine powders; Venenum Bufonis is smashed to pieces, adds the Chinese liquor dipping of 2-3 times amount, often stirs to for subsequent use in paste;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 3-7 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

(4) get Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae and be placed in medicinal cupping, add 6 times amount clear water and soak 30-60 minute, then the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after step (3) process is added, intense fire boils fire of larding speech with literary allusions and endures 1-2 hour slowly, and filter, filtrate reduced in volume becomes paste, add step (2) gained toad venom plaster and mixing fine powders while hot, stir, refined honey becomes ball, to obtain final product.

The preparation method of above-mentioned treating the poisonous disease with poisonous drugs treatment esophageal carcinoma pill, preferred scheme is, in step (2), the concentration of sodium hydroxide solution is the concentration of the preferred sodium hydroxide solution of 0.5%-1.5%(is 0.75%-1.25%, and the concentration of the sodium hydroxide solution be more preferably is 1.0%).

The preparation method of above-mentioned treating the poisonous disease with poisonous drugs treatment esophageal carcinoma pill, preferred scheme is, the middle 60-100 mesh sieve excessively of step (2) (preferred 70-90 mesh sieve excessively, mistake 80 mesh sieve be more preferably).

The preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma, be made into pharmaceutically acceptable decoction, preparation method is: Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned by (1), drains, and explodes to crisp with Oleum sesami, takes out, is pressed into powder, puts in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 3-5 hour (preferred, coddle, 4 hours), taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) be placed in hermetic container by Mylabris, the concentration adding 4-8 times amount volume is sodium hydroxide solution immersion 8-10 hour (preferred, to soak 9 hours) of 0.5%-1.5%, takes out Mylabris, dry, levigation; Venenum Bufonis is smashed to pieces, and add the Chinese liquor dipping of 2-3 times amount, often stir to being paste, 105 DEG C dry, pulverize for subsequent use; Mix with step (1) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder, Armadillidium powder and Fructus Bruceae powder, cross 80 mesh sieves, obtain mixing fine powders, be placed in penetrating bag, for subsequent use;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 3-7 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

(4) get Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae and be placed in medicinal cupping, add 6 times amount clear water and soak 30-60 minute, then add the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after the middle gained mixing fine powders of step (2) and step (3) process, intense fire boils and turns slow fire boiling 1.5-2.5 hour (preferred, intense fire boils and turns slow fire boiling 2 hours), filter, filtrate is concentrated into crude drug with water quality than being 1:3, stopping, sterilizing, encapsulation, obtains decoction.

The preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma, be made into pharmaceutically acceptable powder, preparation method is:

(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 3-5 hour, taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) be placed in hermetic container by Mylabris, the concentration adding 4-8 times amount volume is sodium hydroxide solution immersion 6-9 hour (preferably soaking 7.5 hours) of 0.7%-1.3%, takes out Mylabris, dry, levigation; Venenum Bufonis is smashed to pieces, and add the Chinese liquor dipping of 2-3 times amount, often stir to being paste, 105 DEG C dry, pulverize for subsequent use;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 4-6 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, grind for subsequent use;

(4) Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae are cleaned, dry, be placed in pulverizer to pulverize, mix with step (1)-(3) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder, Armadillidium powder, Fructus Bruceae powder, powder of cantharide, Venenum Bufonis powder and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) powder, stir, sieve, subpackage, obtains powder.

The preparation method of above-mentioned treating the poisonous disease with poisonous drugs treatment esophageal carcinoma powder, preferred scheme is, the middle 80-120 mesh sieve excessively of step (4) (preferred 90-110 mesh sieve excessively, mistake 100 mesh sieve be more preferably).

The preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma, be made into pharmaceutically acceptable thick paste agent, preparation method is: Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned by (1), drains, and explodes to crisp with Oleum sesami, takes out, is pressed into powder, puts in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 2-6 hour (preferred coddle 4 hours), taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) be placed in hermetic container by Mylabris, the sodium hydroxide solution adding 4-8 times amount volume soaks 7-10 hour (preferably soaking 8 hours), takes out Mylabris, drying, levigation, mixes with step (1) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder, Armadillidium powder and Fructus Bruceae powder, sieve, obtain mixing fine powders; Venenum Bufonis is smashed to pieces, adds the Chinese liquor dipping of 2-3 times amount, often stirs to for subsequent use in paste;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 3-7 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

(4) get Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae and be placed in medicinal cupping, add 6 times amount clear water and soak 30-60 minute, then the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after the middle gained mixing fine powders of step (2) and step (3) process is added, intense fire boils and turns slow fire boiling 1.5-2.5 hour (preferred slow fire boiling 2 hours), filter, filtrate is condensed into 1.28-1.32(50 DEG C) thick paste;

(5) in above-mentioned thick paste, add step (2) gained toad venom plaster, stir, 105 DEG C of sterilizings, obtain thick paste agent.

Treating the poisonous disease with poisonous drugs provided by the invention treatment esophageal carcinoma preparation recipe science, preparation method is simple, products obtained therefrom taking convenience, evident in efficacy.In addition, excellent results of the present invention also shows:

1,the present invention mainly adopts pure Chinese medicinal preparation, medicine directly acts on cancerous issue, make effective ingredient can arrive focus rapidly, improve the availability of medicine, effectively can kill the growth of cancerous cell and anticancer, and prevent cancerous cell from spreading, thus play the effect of inhibition tumor cell growth and transfer.

2,products obtained therefrom of the present invention has dredging esophagus, stopping nausea and vomiting by lowering the adverse flow of QI, removing toxic substances of reducing phlegm, alleviating pain, presses down the effect that cancer is anticancer, strengthen immunity, extending life, is mainly used in esophageal carcinoma.

3,medication effect of the present invention is good, taking convenience, and action effect is remarkable.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Herba Catharanthi Rosei: base is former: be Apocynaceae periwinkle plant Herba Catharanthi Rosei, the herb of yellow Herba Catharanthi Rosei.Composition: plant containing indoles alkaloid more than 70 in Herba Catharanthi Rosei, comprise vinblastine, vincristine, lochnericine, lochnericine, remove acetyl vindorosine, vincaleucoblastine, Changchun Buddhist nun is fixed, lochnerinine etc.Root containing alkaloid, comprises that 9-methoxycorynantheidine., akuammicine, west, Changchun are fixed, lochnerivine, cavineine sulfate, sulphuric acid stay around western language alkali, and ammocalline, sulphuric acid group is around raw etc.Pharmacology: 1. antitumor action Herba Catharanthi Rosei contains vinblastine, vincristine, leurosine, leurosidine have obvious antitumor action.2. Antitumor Mechanism Herba Catharanthi Rosei antitumor action is directly relevant to the high-affinity of tubulin binding with medicine, suppress nucleic acid synthesis be it another mechanism.No matter 3. blood pressure lowering and vasodilative effect catharanthus roseus total alkaloids gavage, intramuscular injection or quiet note all have hypotensive effect to anesthetized dog, also has the effect of expansion coronary vasodilator.4. the water extract of blood sugar lowering and effect for reducing blood fat this product leaf has normal or alloxan diabetes rabbit and dog and reduces blood glucose effect.The property of medicine: bitter, cold, poisonous.Function cures mainly: detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver.Cure mainly multiple cancerous protuberance, hypertension, carbuncle sore tumefacting virus, scald.

Scorpio: base is former: be the dry Scorpio of Buthidae animal Scorpio.Chemical analysis: containing scorpion venom is the Neurotoxic protein of a kind of similar snake venom.In addition, and containing trimethylamine, betanin, taurine, palmitic acid, stearic acid, cholesterol, lecithin and ammonium salt etc.Pharmacological action: 1. anticonvulsant action, 2. to the effect of cardiovascular system.Nature and flavor: salty pungent are flat, poisonous.Gui Jing: " guiding principle day ": " meridian of Foot-JUE YIN." function cures mainly: dispel the wind, relieving convulsion, dredging collateral, removing toxic substances.Control infantile convulsion to take out and pluck, epilepsy, apoplexy, hemiplegia, facial hemiparalysis, migraine, rheumatic arthralgia, tetanus, tuberculous lymphadenitis, rubella skin ulcer swells.

Bombyx Batryticatus: base is former: for the larva of Bombycidae insecticide bombyx mori infects muscardine and ossified dry Scorpio.Chemical analysis: containing ammonium oxalate in the white lead of Bombyx Batryticatus body surface.Nature and flavor: Xin Xian are flat.Gui Jing: enter liver, lung, stomach warp.Function cures mainly: expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Control apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble.Sore throat, scrofula tuberculosis.Wind skin ulcer urticaria, erysipelas, mastitis.

Fructus Bruceae: base is former: be the fruit of quassia Fructus Bruceae.Chemical analysis: Fructus Bruceae claims bruceolic acid etc. containing alkaloid (brucamarine and yatanine etc.), glucoside (brucealin, brucealin etc.), phenolic constituent (brucenol etc.) and a kind of hydroxy carboxylic acid.Pharmacological action: 1. anti-ameba effect, 4. Antimalarial, 3. anthelmintic effect, 4. controls wart and papillary tumor, 5. other effects.Nature and flavor: bitter, cold, poisonous.Function cures mainly: heat clearing away, dampness, parasite killing, removing toxic substances.Control dysentery, chronic diarrhea, malaria, hemorrhoid, furunculosis, wart, clavus.

Radix Tripterygii Wilfordii: base is former: be root, the Ye Jihua of Celastraceae plant Radix Tripterygii Wilfordii.Chemical analysis: root throws away the alkaloids such as alkali, wilforgine, wilfortrine and wilfozine containing wilfordine, Radix Tripterygii Wilfordii.Pharmacological action: insecticidal action: the infusion of Radix Tripterygii Wilfordii and ethanol immersion all have the ability of poisoning Folium pyri star caterpillar and leaf folder; But its petroleum ether, ether or three oxygen methane immersion, then there is no killing ability.Toxicity: Radix Tripterygii Wilfordii is different to various animal toxicity, it is very large to the toxicity of people, dog, pig and insecticide, can occur poisoning even dead, but to sheep, rabbit, cat, Mus, fish but avirulence.The effect of Radix Tripterygii Wilfordii to body has two: one for the stimulation to gastrointestinal tract local; Two is the infringement to central nervous system (comprising Thalamus, midbrain, oblongata, cerebellum and spinal cord) after absorption, and causes the hemorrhage and necrosis of liver, the heart.Have meaning Radix Tripterygii Wilfordii mainly to poison the heart of animal, but to other smooth muscle and striped muscle also toxic, this is poisoning lethal reason.Poisoning rear emergency treatment is the conventional methods such as emetic, gastric lavage, coloclysis, catharsis, utilizes detoxification biology of Sanguis caprae seu ovis or rabbit stomach leachate not yet to determine.The toxic component of Radix Tripterygii Wilfordii can leach with ether, but through reduction, toxicity disappears completely.Nature and flavor: " Hunan medicine will ": " bitter, poison greatly." function cures mainly: " Hunan medicine will ": " parasite killing, antiinflammatory, removing toxic substances." Radix Tripterygii Wilfordii is a kind of hypertoxic medicine, especially skin zone's toxicity is very big, strictly should peel skin zone off during use, and the skin comprised in diploid skin and tree seam divides.

Radix Patriniae heterophyllae: base is former: be the root of Valerianaceae plant Radix Patriniae Scabrae, Radix Patriniae Scabrae.Pharmacological action: Radix Patriniae heterophyllae preparation, through preliminary test, has suppression and injury effect in vitro to ehrlich carcinoma cell; Oral to suffering from Ehrlich ascites carcinoma, to the injection of Emhorn solid carcinoma mouse peritoneal or this preparation of subcutaneous injection, also there is certain curative effect.Nature and flavor: " Guangxi Chinese medicinal herbal ": " acrid in the mouth, warm in nature." return through " Guangxi Chinese medicinal herbal ": " enter the heart, liver two warp." function cures mainly: control pyrexial malaria, women's metrorrhagia, leucorrhea with red and white discharge, traumatic injury.

Concha Arcae: base is former: be the shell of Carnis Arca inflata section animal Scapharca broughtonii, Tegillarca granosa or Scapharca subcrenata.Nature and flavor: Gan Xian are flat.Gui Jing: enter liver, spleen channel.Function cures mainly: reduce phlegm, softening the hard mass, dissipating blood stasis, removing food stagnancy.Control accumulation of phlegm, stomachache, noisy, acid regurgitation, lump in the abdomen, scrofula, ulcerative gingivitis.

Mylabris: base is former: be the dry Scorpio of Meloidae insecticide Mylabris phalarata or yellow black mylabris cichorii.Chemical analysis: Mylabris phalarata contains cantharidin 1 ~ 1.2%, fat 12% and resin, formic acid, pigment etc.Yellow black mylabris cichorii (Taiwan product person) containing cantharidin 0.97%, but also has and reaches 1.3%.In addition, general Mylabris is containing cantharidin 1 ~ 1.5%.Pharmacological action: 1. foaming effect, 2. antitumor action, 3. other effects.Toxicity: this product belongs to hypertoxic medicine.Chmice acute is tested, and the median lethal dose(LD 50) of lumbar injection is 1.25 mgs/kg; Its internal organs cut sections for microscopic examination, no matter acute or subacute toxicity test, all there is pathological changes in each internal organs: cardiac muscle fiber cloudy swelling is obviously (especially with subacute test being); Hepatocyte cloudy swelling, fat become; Lung, cyanosis lienic, and have collections hemorrhage; Renal tubular epithelial cloudy swelling.Cantharidin 30 milligrams can make people dead.Nature and flavor: pungent, cold, poisonous.Gui Jing: enter large intestine, small intestinal, liver, kidney channel.Function cures mainly: counteracting toxic substances, removing blood stasis.Malignant boil is controlled in external, stubborn dermatitis, facial hemiparalysis, throat moth; Take orally and control scrofula, lyssodexis.

Venenum Bufonis: base is former: be the ear rear gland of Bufonidae animal Bufo siccus or Bufo melanostictus etc. and the white serosity of skin gland secretion, form through dry processing.Chemical analysis: Bufo siccus serosity solids formed by the dry processing, Venenum Bufonis by name.Slurry content is complicated; The ten's of last century are separated similar active substance successively, reach tens of kinds more than so far after being separated bufagin.This type of material all has the effects such as heart tonifying, chemically belonging to steroid, and its C17 connects again one α-pyrans ketone group, all materials with this kind of skeleton (in fact, also the material with this kind of skeleton is had) in plant, total bufadienolide is the principle active component of Bufo siccus serosity, Venenum Bufonis.Bufadienolide contained in Venenum Bufonis has: 1. bufotalin.2. cinobufagin, Venenum Bufonis main constituent, containing rate 7.2 ± 0.2%.3. cinobufotalin, be also that bufonid toad main constituent is supported in Europe, local anesthesia power is only second to bufalin.4. telecinobufagin.5. bufalin, local anesthesia power the maximum in Venenum Bufonis.6. gamabufotalin, has another name called gammabufogenin.7. Dosacetyl Cinobufotalin.8. this bufolin is invited.9. cinobufotalidin.10. bufotalinin.Cinobufaginol.Arenobufagin.Bufarenogin.Desacetylcinobufagin.Desacetylbufotalin.Bufotalidin, i.e. bufotalidin.(17) resibufagin etc.Pharmacological action: 1. cardiotonic, 2. to the effect of breathing, blood pressure, 3. local anesthesia effect, 4. to the effect of central nervous system, 5. to the effect of striped muscle, smooth muscle, 6. to relieving asthma, antitussive effect, 7. antiinflammatory, antitumor, anti-radiation function, 8. absorbs and excretion.Nature and flavor: sweet, acrid, warm are poisonous.Gui Jing: " explaining abstruseness of the canon of materia medica ": " enter foot sun bright, few cloudy." function cures mainly: removing toxic substances, detumescence, heart tonifying, pain relieving.Control furuncle, carbuncle, carbuncle on the back, scrofula, chronic osteomyelitis, laryngopharynx swelling and pain, infantile malnutrition, heart failure, wind, carious pain.

Armadillidium: base is former: for the drying of Armadillidium section animal armadillidum vulgare is all.Chemical analysis: the also unit sugar of armadillidum vulgare changes because of growth period with glycogen content; Its mucopolysaccharide is containing chondroitin sulfate A or C, or have non-saponifiable matter 10% containing in the contained lipid of glass (alditol) acid, acetone not fat melting 5%, the fatty acid after saponification consists of tetradecylic acid 0.7, hexadecylic acid 20.6, stearic acid 8.3, twenty acid 0.7, octadecenoic acid 53.7, octadecadienoic acid 10.1, jeceric acid 2.5, other unsaturated fatty acid 3.2%; Non-saponifiable matter, containing 41.0% sterol, is wherein mainly cholesterol, also may contains formic acid.Nature and flavor: acid are cool.Gui Jing: " detailed outline ": " JUE YIN meridian." function cures mainly: removing blood stasis, diuretic, removing toxic substances, pain relieving.Control chronic malaria malaria with splenomegaly, amenorrhea lump in the abdomen, urinary obstruction, infantile convulsion locked jaw, ability to speak pain, all skin ulcers of thrush.

Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): base is former: be the tuber of ranunculaceae plant Aconitum kongboense Lauener.Nature and flavor: warm in nature, bitter in the mouth fiber crops, very toxic.Function cures mainly: anti-inflammatory analgetic, expelling wind and removing dampness.

Herba Hedyotidis Diffusae: base is former: be the whole herb with root of Radix Rubiae kind of plant Herba Hedyotidis Diffusae.Chemical analysis: separate 1 alkane, stigmasterol, ursolic acid, oleanolic acid in herb, cupreol, cupreol-D-Glucose glycoside, P-coumaric acid etc.Pharmacological action: 1. antitumor action, 2. antibacterial, antiinflammation, nature and flavor: bitter sweet, cold.Nature and flavor: bitter sweet, cold.Function cures mainly: heat clearing away, dampness removing, removing toxic substances.Control dyspnea and cough due to lung-heat, tonsillitis.Pharyngolaryngitis, appendicitis, dysentery, urinary tract infection, jaundice, hepatitis, pelvic inflammatory disease, adnexitis, carbuncle furuncle, venom, tumor.Also can be used for alimentary tract cancer.

Shishou Air Bladder pseudosciaenae seu Acipenser: base is former: be the Air Bladder pseudosciaenae seu Acipenser of Sciaenidae animal Carnis Pseudosciaenae or Carnis Pseudosciaenae.Nature and flavor: sweet are flat.Gui Jing: " book on Chinese herbal medicine is newly organized ": " enter kidney." function cures mainly: the kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, dissipating blood stasis, detumescence.Control spermatorrhea of suffering from a deficiency of the kidney, puerperal puerperal tetanus, tetanus, spit blood, metrorrhagia, wound hemorrhage, hemorrhoid.

embodiment 1the preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma, is prepared from by following bulk drugs, is weight portion: Scorpio 9g, Bombyx Batryticatus 10g, Fructus Bruceae 8g, Radix Tripterygii Wilfordii 6g, Radix Patriniae heterophyllae 8g, Concha Arcae 10g, Mylabris 3g, Venenum Bufonis 2g, Herba Catharanthi Rosei 3g, Armadillidium 4g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 3g, Herba Hedyotidis Diffusae 9g, Shishou Air Bladder pseudosciaenae seu Acipenser 8g.

The preparation method of above-mentioned treating the poisonous disease with poisonous drugs treatment esophageal carcinoma pill is:

(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 2 hours, taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use;

(2) Mylabris is placed in hermetic container, the concentration adding 4-8 times amount volume be 0.5% sodium hydroxide solution soak 6 hours, take out Mylabris, drying, levigation, mixes with step (1) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder and Armadillidium powder, cross 60 mesh sieves, obtain mixing fine powders; Venenum Bufonis is smashed to pieces, adds the Chinese liquor dipping of 2-3 times amount, often stirs to for subsequent use in paste;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 3-7 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

(4) get Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae and be placed in medicinal cupping, add 6 times amount clear water and soak 30-60 minute, then the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after step (3) process is added, intense fire boils fire of larding speech with literary allusions and endures 1-2 hour slowly, and filter, filtrate reduced in volume becomes paste, add step (2) gained toad venom plaster and mixing fine powders while hot, stir, refined honey becomes ball, to obtain final product.

The instructions of taking of pill of the present invention is: twice daily, each 2-4 ball, and 20 days courses for the treatment of, period in a medicine avoids maror.

Typical case: Deng XX, man, 49 years old, on July 19th, 2011 went to a doctor.Patient occurs swallowing not smooth without obvious inducement at the beginning of 2011 6 months, go the row gastroscopy display of local Concord Hospital: the occupy-place of esophagus lower end ulcer protuberance property.Pathological examination shows: middle differentiated squamous-cell carcinomas.Be diagnosed as: the esophageal carcinoma.Because patient is esophageal carcinoma Locally Advanced, therefore cannot excision.Check: patient's xerostomia, swallow pain, tell tedious, red tongue, tongue is greasy in vain, rapid pulse.

Take the present embodiment gained treating the poisonous disease with poisonous drugs treatment esophageal carcinoma pill, after the course for the treatment of, feed is choked with sobs and is alleviated, and continues to take four the breast CT displays course for the treatment of, and focus obviously reduces, and follows up a case by regular visits to so far, patient experiences stable disease.

embodiment 2the preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma, is prepared from by following bulk drugs, is weight portion: Scorpio 15g, Bombyx Batryticatus 20g, Fructus Bruceae 16g, Radix Tripterygii Wilfordii 15g, Radix Patriniae heterophyllae 12g, Concha Arcae 20g, Mylabris 6g, Venenum Bufonis 5g, Herba Catharanthi Rosei 5g, Armadillidium 6g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 6g, Herba Hedyotidis Diffusae 15g, Shishou Air Bladder pseudosciaenae seu Acipenser 12g.

The preparation method of above-mentioned treating the poisonous disease with poisonous drugs treatment esophageal carcinoma decoction is:

(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 4 hours, taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use;

(2) be placed in hermetic container by Mylabris, the concentration adding 4-8 times amount volume is that the sodium hydroxide solution of 0.5%-1.5% soaks 9 hours, takes out Mylabris, dry, levigation; Venenum Bufonis is smashed to pieces, and add the Chinese liquor dipping of 2-3 times amount, often stir to being paste, 105 DEG C dry, pulverize for subsequent use; Mix with step (1) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder and Armadillidium powder, cross 80 mesh sieves, obtain mixing fine powders, be placed in penetrating bag, for subsequent use;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 3-7 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

(4) get Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae and be placed in medicinal cupping, add 6 times amount clear water and soak 30-60 minute, then the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after the middle gained mixing fine powders of step (2) and step (3) process is added, intense fire boils and turns slow fire boiling 2 hours, filters, and filtrate is concentrated into crude drug with water quality than being 1:3, stop, sterilizing, encapsulation, obtains decoction.

The instructions of taking of decoction of the present invention is: once a day, each 150-200 milliliter, and 20 days courses for the treatment of, period in a medicine avoids maror.

Typical case: Cui XX, man, 62 years old, retired professor.Feel pharynx food pain in May, 2010, eat harder food and easily to choke food, the state of an illness increases the weight of gradually, and patient obviously becomes thin, and mouth tells dense saliva, often chest and back pain, is hard and dry, and belly distension is uncomfortable afterwards for food, can eat some gruel reluctantly, here inquiring in July.X-ray barium meal takes the photograph sheet display: stage casing esophagus has 10 cm mild stenosis, and mucosa is stiff, filling defect, is diagnosed as the esophageal carcinoma.

Take this enforcement gained treating the poisonous disease with poisonous drugs treatment esophageal carcinoma decoction, after taking a course for the treatment of, pharynx resistance sense alleviates, and still tells mucus, the pain over the chest and back alleviates, and defecates slightly dry, and after continuing to take three courses for the treatment of, each symptom has clear improvement, can swallow common food, two is just normal, can be engaged in light physical labor.

embodiment 3the preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma, is prepared from by following bulk drugs, is weight portion: Scorpio 11g, Bombyx Batryticatus 14g, Fructus Bruceae 10g, Radix Tripterygii Wilfordii 8g, Radix Patriniae heterophyllae 9g, Concha Arcae 14g, Mylabris 4g, Venenum Bufonis 3g, Herba Catharanthi Rosei 3.5g, Armadillidium 4.5g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4g, Herba Hedyotidis Diffusae 11g, Shishou Air Bladder pseudosciaenae seu Acipenser 9g.

The preparation method of above-mentioned treating the poisonous disease with poisonous drugs treatment esophageal carcinoma powder is:

(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 4 hours, taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use;

(2) be placed in hermetic container by Mylabris, the concentration adding 4-8 times amount volume is that the sodium hydroxide solution of 0.7%-1.3% soaks 7.5 hours, takes out Mylabris, dry, levigation; Venenum Bufonis is smashed to pieces, and add the Chinese liquor dipping of 2-3 times amount, often stir to being paste, 105 DEG C dry, pulverize for subsequent use;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 4-6 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, grind for subsequent use;

(4) Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae are cleaned, dry, be placed in pulverizer to pulverize, mix with step (1)-(3) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder, Armadillidium powder, powder of cantharide, Venenum Bufonis powder and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) powder, stir, cross 100 mesh sieves, subpackage (7g/ bag), obtains powder.

The instructions of taking of powder of the present invention is: every day 3 times, and each 1 bag, 20 days courses for the treatment of, period in a medicine avoids maror.

Typical case: cattle XX, man, 53 years old, people from Hebei.In JIUYUE, 2010 because of esophagus uncomfortable, be esophageal carcinoma mid-term in local hospital inspection, at hospitalize 2 wheat harvesting period, DeGrain, rice, shipwreck are entered, and figure is become thin.In March, 2011 upon somebody's introduction, comes here and sees a doctor.Check: chest and diaphragm feeling of fullness, singultus belch, vomiting sputum, dry mouth and throat, red tongue, tire is micro-greasy, thready and rolling pulse.

Take the present embodiment gained treating the poisonous disease with poisonous drugs treatment esophageal carcinoma powder, after two courses for the treatment of, can eat gruel, drink water, urine is increased.Hold on four courses for the treatment of of treatment, and patient diet is as usual, and physical recovery is normal, goes hospital's further consultation, and cancerous cell disappears, and all indexs recover normal.

embodiment 4the preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma, is prepared from by following bulk drugs, is weight portion: Scorpio 13g, Bombyx Batryticatus 16g, Fructus Bruceae 14g, Radix Tripterygii Wilfordii 13g, Radix Patriniae heterophyllae 11g, Concha Arcae 16g, Mylabris 5g, Venenum Bufonis 4g, Herba Catharanthi Rosei 4.5g, Armadillidium 5.5g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5g, Herba Hedyotidis Diffusae 13g, Shishou Air Bladder pseudosciaenae seu Acipenser 11g.

The preparation method of above-mentioned treating the poisonous disease with poisonous drugs treatment esophageal carcinoma thick paste agent is:

(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 4 hours, taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use;

(2) be placed in hermetic container by Mylabris, the sodium hydroxide solution adding 4-8 times amount volume soaks 8 hours, takes out Mylabris, and dry, levigation, mixes with step (1) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder and Armadillidium powder, sieve, obtain mixing fine powders; Venenum Bufonis is smashed to pieces, adds the Chinese liquor dipping of 2-3 times amount, often stirs to for subsequent use in paste;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 3-7 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

(4) get Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae and be placed in medicinal cupping, add 6 times amount clear water and soak 30-60 minute, then the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after the middle gained mixing fine powders of step (2) and step (3) process is added, intense fire boils and turns slow fire boiling 2 hours, filter, filtrate is condensed into 1.28-1.32(50 DEG C) thick paste;

(5) in above-mentioned thick paste, add step (2) gained toad venom plaster, stir, 105 DEG C of sterilizings, obtain thick paste agent.

The instructions of taking of thick paste agent of the present invention is: twice daily, each 1-2 spoon, warm boiled water, and 20 days courses for the treatment of, period in a medicine avoids maror.

Typical case a: XX, female, 45 years old.Patient's readme: from 2008 because suffering from chronic esophagitis, gastritis, often takes medicine treatment, but does not cure.Feel in March, 2010 to have a meal not as in the past, some difficulty, has a meal, drinks water less than 5 minutes, just tells out, stool is often dry, two to three days are once uncomfortable in chest, lean body mass, go that local hospital inspection is diagnosed as early, mid-term Middle esophageal cancer, local hospital treatment March more than, poor effect, health significantly declines, and carrys out here diagnosis and treatment upon somebody's introduction.

Take the agent of the present embodiment gained treating the poisonous disease with poisonous drugs treatment esophageal carcinoma thick paste, after two courses for the treatment of, sb.'s illness took a favorable turn, has a meal, drinks water and do not vomit, and defecates by original three days once, become once a day, hold on three courses for the treatment of of treatment, and the state of an illness is almost recovered, and checks to local hospital, result display cancerous cell disappears, and physical recovery is normal.Follow up a case by regular visits to so far, patient is without recurrence.

embodiment 5the preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma, is prepared from by following bulk drugs, is weight portion: Scorpio 12g, Bombyx Batryticatus 15g, Fructus Bruceae 2g, Radix Tripterygii Wilfordii 10.5g, Radix Patriniae heterophyllae 10g, Concha Arcae 15g, Mylabris 4.5g, Venenum Bufonis 3.5g, Herba Catharanthi Rosei 4g, Armadillidium 5g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4.5g, Herba Hedyotidis Diffusae 12g, Shishou Air Bladder pseudosciaenae seu Acipenser 10g.

The preparation method of above-mentioned treating the poisonous disease with poisonous drugs treatment esophageal carcinoma pill is:

(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 4 hours, taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use;

(2) Mylabris is placed in hermetic container, the concentration adding 4-8 times amount volume be 1.0% sodium hydroxide solution soak 9 hours, take out Mylabris, drying, levigation, mixes with step (1) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder and Armadillidium powder, cross 80 mesh sieves, obtain mixing fine powders; Venenum Bufonis is smashed to pieces, adds the Chinese liquor dipping of 2-3 times amount, often stirs to for subsequent use in paste;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 3-7 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

(4) get Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae and be placed in medicinal cupping, add 6 times amount clear water and soak 30-60 minute, then the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after step (3) process is added, intense fire boils fire of larding speech with literary allusions and endures 1-2 hour slowly, and filter, filtrate reduced in volume becomes paste, add step (2) gained toad venom plaster and mixing fine powders while hot, stir, refined honey becomes ball, to obtain final product.

The instructions of taking of pill of the present invention is: twice daily, each 2-4 ball, and 20 days courses for the treatment of, period in a medicine avoids maror.

test example 1the applied research of embodiment 5 gained treating the poisonous disease with poisonous drugs treatment esophageal carcinoma pill:

1, data and method

1.1 case sources

213 routine cases all come from-2012 years in October, 2010 December 5 hospital's oncologies, patient age scope 38-76 year, 53.59 ± 1.26 years old mean age.Wherein male patient 145 example, female patient 68 example.In all patients, early stage patient 85 example, mid-term, patient with esophageal carcinoma 73 was routine, late esophagus cancer patient 55 example.

1.2 screening criteria

(1) through pathology or imaging examination, meet Western medicine diagnose standard, be diagnosed as the esophageal carcinoma; (2) traditional Chinese medical science " dysphagic " category is belonged to;

1.3 Therapeutic Method

All patients all take and are implemented example 5 gained treating the poisonous disease with poisonous drugs treatment esophageal carcinoma pill, and instructions of taking is: twice daily, each 2-4 ball, and 20 days courses for the treatment of, period in a medicine avoids maror.Observe five courses for the treatment of of treatment altogether.

1.4 curative effect determinate standard

Basic healing: tumor all disappears, Continuous Observation more than 2 years, without recurrence, can orthobiosis, work.

Effective: tumor regression is over half, and maintain more than 1 year person; Patient can people's live and work as usual.

Effective: below tumor regression half, and maintain more than 1 year person;

Invalid: symptom is as treated front or increasing the weight of.

1.5 therapeutic outcome

Table 1 uses embodiment 5 product 38-76 year patient with esophageal carcinoma therapeutic outcome

The vinblastine that in side, Herba Catharanthi Rosei contains, vincristine, leurosine, leurosidine have obvious antitumor action; Scorpio has dispels the wind, relieving convulsion, dredging collateral, the effect of removing toxic substances; Bombyx Batryticatus enters liver, lung, stomach warp.Cure mainly expelling wind to relieve convulsion, dissipating phlegm and resolving masses; Fructus Bruceae, containing alkaloid, has heat clearing away, dampness, parasite killing, effect of removing toxic substances; Radix Tripterygii Wilfordii parasite killing, antiinflammatory, removing toxic substances; Radix Patriniae heterophyllae acrid in the mouth, warm in nature; Radix Patriniae heterophyllae preparation, through preliminary test, has suppression and injury effect in vitro to ehrlich carcinoma cell; Venenum Bufonis sweet, acrid, warm, poisonous; Cure mainly: removing toxic substances, detumescence, heart tonifying, pain relieving; Herba Hedyotidis Diffusae has antitumor, antibacterial, antiinflammation; Shishou Air Bladder pseudosciaenae seu Acipenser the kidney invigorating and essence nourishing, nourishes muscle arteries and veins.The all medicines of we share, and can mutually adjust, treating the poisonous disease with poisonous drugs reaches the object of killing tumor cell.Total effective rate 97.7%.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. the preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma, is characterized in that: be prepared from by following bulk drugs, is weight portion: Scorpio 9-15, Bombyx Batryticatus 10-20, Fructus Bruceae 8-16, Radix Tripterygii Wilfordii 6-15, Radix Patriniae heterophyllae 8-12, Concha Arcae 10-20, Mylabris 3-6, Venenum Bufonis 2-5, Herba Catharanthi Rosei 3-5, Armadillidium 4-6, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 3-6, Herba Hedyotidis Diffusae 9-15, Shishou Air Bladder pseudosciaenae seu Acipenser 8-12.

2. the preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma as claimed in claim 1, is characterized in that: be prepared from by following bulk drugs, is weight portion: Scorpio 11-13, Bombyx Batryticatus 14-16, Fructus Bruceae 10-14, Radix Tripterygii Wilfordii 8-13, Radix Patriniae heterophyllae 9-11, Concha Arcae 14-16, Mylabris 4-5, Venenum Bufonis 3-4, Herba Catharanthi Rosei 3.5-4.5, Armadillidium 4.5-5.5, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4-5, Herba Hedyotidis Diffusae 11-13, Shishou Air Bladder pseudosciaenae seu Acipenser 9-11.

3. the preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma as claimed in claim 1, is characterized in that: be prepared from by following bulk drugs, is weight portion: Scorpio 12, Bombyx Batryticatus 15, Fructus Bruceae 2, Radix Tripterygii Wilfordii 10.5, Radix Patriniae heterophyllae 10, Concha Arcae 15, Mylabris 4.5, Venenum Bufonis 3.5, Herba Catharanthi Rosei 4, Armadillidium 5, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4.5, Herba Hedyotidis Diffusae 12, Shishou Air Bladder pseudosciaenae seu Acipenser 10.

4. the preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is:

(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 2-6 hour (preferred coddle 4 hours), taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) be placed in hermetic container by Mylabris, the sodium hydroxide solution adding 4-8 times amount volume soaks 6-12 hour (preferably soaking 9 hours), takes out Mylabris, drying, levigation, mixes with step (1) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder, Armadillidium powder and Fructus Bruceae powder, sieve, obtain mixing fine powders; Venenum Bufonis is smashed to pieces, adds the Chinese liquor dipping of 2-3 times amount, often stirs to for subsequent use in paste;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 3-7 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

(4) get Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae and be placed in medicinal cupping, add 6 times amount clear water and soak 30-60 minute, then the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after step (3) process is added, intense fire boils fire of larding speech with literary allusions and endures 1-2 hour slowly, and filter, filtrate reduced in volume becomes paste, add step (2) gained toad venom plaster and mixing fine powders while hot, stir, refined honey becomes ball, to obtain final product.

5. the preparation method for the treatment of the poisonous disease with poisonous drugs treatment esophageal carcinoma pill according to claim 4, it is characterized in that, in step (2), the concentration of sodium hydroxide solution is the concentration of the preferred sodium hydroxide solution of 0.5%-1.5%(is 0.75%-1.25%, and the concentration of the sodium hydroxide solution be more preferably is 1.0%).

6. the preparation method for the treatment of the poisonous disease with poisonous drugs treatment esophageal carcinoma pill according to claim 4, is characterized in that, the middle 60-100 mesh sieve excessively of step (2) (preferred 70-90 mesh sieve excessively, mistake 80 mesh sieve be more preferably).

7. the preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is:

(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 3-5 hour (preferred, coddle, 4 hours), taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) be placed in hermetic container by Mylabris, the concentration adding 4-8 times amount volume is sodium hydroxide solution immersion 8-10 hour (preferred, to soak 9 hours) of 0.5%-1.5%, takes out Mylabris, dry, levigation; Venenum Bufonis is smashed to pieces, and add the Chinese liquor dipping of 2-3 times amount, often stir to being paste, 105 DEG C dry, pulverize for subsequent use; Mix with step (1) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder, Armadillidium powder and Fructus Bruceae powder, cross 80 mesh sieves, obtain mixing fine powders, be placed in penetrating bag, for subsequent use;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 3-7 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

(4) get Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae and be placed in medicinal cupping, add 6 times amount clear water and soak 30-60 minute, then add the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after the middle gained mixing fine powders of step (2) and step (3) process, intense fire boils and turns slow fire boiling 1.5-2.5 hour (preferred, intense fire boils and turns slow fire boiling 2 hours), filter, filtrate is concentrated into crude drug with water quality than being 1:3, stopping, sterilizing, encapsulation, obtains decoction.

8. the preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable powder, preparation method is:

(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 3-5 hour, taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) be placed in hermetic container by Mylabris, the concentration adding 4-8 times amount volume is sodium hydroxide solution immersion 6-9 hour (preferably soaking 7.5 hours) of 0.7%-1.3%, takes out Mylabris, dry, levigation; Venenum Bufonis is smashed to pieces, and add the Chinese liquor dipping of 2-3 times amount, often stir to being paste, 105 DEG C dry, pulverize for subsequent use;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 4-6 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, grind for subsequent use;

(4) Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae are cleaned, dry, be placed in pulverizer to pulverize, mix with step (1)-(3) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder, Armadillidium powder, Fructus Bruceae powder, powder of cantharide, Venenum Bufonis powder and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) powder, stir, sieve, subpackage, obtains powder.

9. the preparation method for the treatment of the poisonous disease with poisonous drugs treatment esophageal carcinoma powder according to claim 8, is characterized in that, the middle 80-120 mesh sieve excessively of step (4) (preferred 90-110 mesh sieve excessively, mistake 100 mesh sieve be more preferably).

10. the preparation of the treating the poisonous disease with poisonous drugs treatment esophageal carcinoma as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable thick paste agent, preparation method is:

(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use; Radix Tripterygii Wilfordii is placed in medicinal cupping, and add fresh Sanguis caprae seu ovis to cover powder for degree, coddle 2-6 hour (preferred coddle 4 hours), taking-up Radix Tripterygii Wilfordii is placed in 60 DEG C of thermostatic drying chambers dries, and grinds into powder for subsequent use; Armadillidium is cleaned, be placed in iron pan, and low baking temperature roasting, to housing jaundice, is taken out, ground into powder, for subsequent use; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) be placed in hermetic container by Mylabris, the sodium hydroxide solution adding 4-8 times amount volume soaks 7-10 hour (preferably soaking 8 hours), takes out Mylabris, drying, levigation, mixes with step (1) gained Shishou Air Bladder pseudosciaenae seu Acipenser powder, Radix Tripterygii Wilfordii powder, Armadillidium powder and Fructus Bruceae powder, sieve, obtain mixing fine powders; Venenum Bufonis is smashed to pieces, adds the Chinese liquor dipping of 2-3 times amount, often stirs to for subsequent use in paste;

(3) Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 3-7 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

(4) get Scorpio, Bombyx Batryticatus, Radix Patriniae heterophyllae, Concha Arcae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae and be placed in medicinal cupping, add 6 times amount clear water and soak 30-60 minute, then the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after the middle gained mixing fine powders of step (2) and step (3) process is added, intense fire boils and turns slow fire boiling 1.5-2.5 hour (preferred slow fire boiling 2 hours), filter, filtrate is condensed into 1.28-1.32(50 DEG C) thick paste;

(5) in above-mentioned thick paste, add step (2) gained toad venom plaster, stir, 105 DEG C of sterilizings, obtain thick paste agent.