CN104398627A

CN104398627A - Esophagus cancer medicament with poison for combating poison and preparation method of esophagus cancer medicament

Info

Publication number: CN104398627A
Application number: CN201410760901.0A
Authority: CN
Inventors: 李菲
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-12-13
Filing date: 2014-12-13
Publication date: 2015-03-11

Abstract

The invention discloses an esophagus cancer medicament with poison for combating poison. The medicament is prepared from the following raw medicines in parts by weight: 10-20 parts of scorpion, 8-12 parts of red ochre, 9-15 parts of brucea javanica, 3-5 parts of borax, 2-4 parts of vinblastine, 10-20 parts of dung beetle, 9-15 parts of tripterygium glycosides, 20 to 40 parts of puerarin, 8-16 parts of diversifolious patrinia root, 2-4 parts of chlorite schist, 4-6 parts of short-pedicel aconite root, 5-10 parts of spreading hedyotis herb and 4-9 parts of drumfish bladder. The medicament provided by the invention has the excellent effects as follows: the medicament mainly adopts pure Chinese traditional medicine preparations; the medicines directly act on cancer tissue, so that the effective components of the medicines can reach lesions quickly and the utilization degree of the medicines is increased; the medicament can effectively kill cancer cells, inhibit the growth of cancer cells and prevent diffusion of cancer cells, thereby playing a role in inhibiting the growth and metastasis of tumor cells. The medicament provided by the invention has a high therapeutic effect, is convenient to take and has a remarkable curative effect.

Description

Esophageal carcinoma treating the poisonous disease with poisonous drugs medicament and preparation method

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of esophageal carcinoma treating the poisonous disease with poisonous drugs medicament and preparation method.

Background technology

The esophageal carcinoma is current one of modal gastrointestinal cancer in the world, and according to WHO histologic classification, the esophageal carcinoma mainly comprises squamous cell carcinoma and esophageal adenocarcinoma two kinds, and the ratio wherein shared by squamous cell carcinoma is up to 90%.And China is Esophageal Cancer area, annual death toll about 150,000 people, accounts for national tumor mortality rate 21.8%.Causing in dead maximum cancer, the esophageal carcinoma ranks the 4th.The age of onset of the esophageal carcinoma is many more than 40 years old, and male is more than women.Incidence of Esophageal Cancer exact cause is fuzzy at present, but find that its morbidity stimulates with carcinogens matter, inflammation and wound, heredity and life habit etc. are multifactor substantial connection.

Esophageal carcinoma clinical manifestation: 1, early stage: symptom is often not obvious, but discomfort sensation in various degree may be had when swallowing thick and stiff food, comprise ingest food choking feeling, after breastbone, burn sample, acupuncture sample or tractive friction sample pain.Food by slow, and has stagnation sense or foreign body sensation.Stalk is choked to stagnate to feel and alleviate disappearance after being swallowed water.Heavy time light during symptom, make slow progress.2, middle and advanced stage: the typical symptom of the esophageal carcinoma is Progressive symmetric erythrokeratodermia acataposis, before this food of difficult dry pharynx is semiliquid diet then, and last water and saliva can not be swallowed.Often telling mucoid expectorant, is the saliva of hypopharynx and the secretions of esophagus.Patient becomes thin gradually, dewater, unable.Lasting chest pain or backache are expressed as symptom in late period, and cancer has been invaded esophagus and organized outward.When cancerous protuberance blocks caused inflammation edema transient remission, or after part cancerous protuberance comes off, obstruction can temporarily alleviate, and constant error thinks that sb.'s illness took a favorable turn.If cancerous protuberance invades recurrent laryngeal nerve, hoarseness can be there is; If compressing cervical sympathetic ganglia, Horner syndrome can be produced; If intrusion trachea-bronchial epithelial cell, esophagus, trachea or bronchial fistula can be formed, acutely choke when occurring swallowing water or food and cough, and respiratory system infection occurs.Finally there is cachectic states.If there is the Organ relative weight such as liver, brain, the states such as jaundice, seroperitoneum, stupor can be there is.The traditional treatment of the esophageal carcinoma comprises the methods such as surgical operation therapy, radiotherapy, chemotherapy and Comprehensive Treatment according to the difference of the state of an illness.The treatment of chemicals, Chinese medicine also achieves challenging curative effect in recent years in addition.

Authorize publication No. CN 102018864 B(application number 201010591088.0) Chinese invention patent document disclose a kind of Chinese medicine and processing method thereof for the treatment of the esophageal carcinoma.Be made up of the raw material of following weight: the Rhizoma Pinelliae 60 grams, Herba Lobeliae Chinensis 40 grams, Herba Hedyotidis Diffusae 80 grams, Semen Impatientis 30 grams, Fructus Chebulae 40 grams, Radix Panacis Quinquefolii 40 grams, Rhizoma Paridis 60 grams, Flos Inulae 60 grams, Endothelium Corneum Gigeriae Galli 40 grams, Herba euphorbiae lunulatae 20 grams, Rhizoma Arisaematis (processed) 20 grams, Hirudo 15 grams, Venenum Bufonis 3 grams, dried Alumen 20 grams, Periostracum Serpentis 40 grams, stir-baked SQUAMA MANITIS 60 grams, Rhizoma Dioscoreae Bulbiferae 40 grams.Authorize publication No. CN 102973805 A(application number 201210516614.6) Chinese invention patent document disclose a kind of Chinese medicine composition for the treatment of the esophageal carcinoma, mixed by weight by following raw materials according: Radix Sophorae Tonkinensis 16-24 gram, Herba Lobeliae Chinensis 22-30 gram, Oletum Trogopterori 8-12 gram, Radix Angelicae Sinensis 8-13 gram, Rhizoma Dioscoreae Bulbiferae 10-15 gram, Radix Glycyrrhizae 15-23 gram, Radix Clematidis 12-17 gram, Rhizoma Et Radix Notopterygii 5-13 gram, Squama Manis 7-15 gram, Radix Ginseng 5-10 gram, Radix Astragali 9-15 gram, Pseudobulbus Cremastrae Seu Pleiones 10-30 gram, Flos Lonicerae 10-20 gram, Scorpio 15-20 gram, Ganoderma 9-17 gram, Radix Notoginseng 20-28 gram.Application publication number CN 103417810 A(application number 201310295242.3) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of the esophageal carcinoma, be made up of the raw material of following weight portion: Haematitum 25-35 part, Herba Agrimoniae 12-25 part, Radix Angelicae Sinensis 5-15 part, Rhizoma Dioscoreae 10-20 part, Radix Trichosanthis 10-20 part, Radix Asparagi 10-20 part, Radix Glycyrrhizae 10-20 part.

At present, traditional operation and radiotherapy can only solve local problem, and operation wound is large, easily shifts; Radiotherapy chemotherapy also can not kill all cancerous cell, and easily forms secondary tumor, loses more than gain.The traditional Chinese medical science finds anticancer effective component from natural drug, enhancing human body immunity function, has Carcinoma cell differentiation and apoptosis, has unique advantage.

Summary of the invention

The object of the invention is, a kind of esophageal carcinoma treating the poisonous disease with poisonous drugs medicament is provided, coordinate make by adding a few herbs raw material, to the growth of containment tumor cell and kill tumor cell and have good effect.

Technical scheme of the present invention is:

Esophageal carcinoma treating the poisonous disease with poisonous drugs medicament, is characterized in that: be prepared from by following bulk drugs, is weight portion: Scorpio 10-20, Haematitum 8-12, Fructus Bruceae 9-15, Borax 3-5, Herba Catharanthi Rosei 2-4, Catharsii molossi 10-20, Radix Tripterygii Wilfordii 9-15, Radix Puerariae 20-40, Radix Patriniae heterophyllae 8-16, Lapis Micae Aureus 2-4, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4-6, Herba Hedyotidis Diffusae 5-10, Shishou Air Bladder pseudosciaenae seu Acipenser 4-9.

In preferred scheme, Scorpio 14-16, Haematitum 9-11, Fructus Bruceae 11-13, Borax 3.5-4.5, Herba Catharanthi Rosei 2.5-3.5, Catharsii molossi 14-16, Radix Tripterygii Wilfordii 11-13, Radix Puerariae 25-35, Radix Patriniae heterophyllae 10-14, Lapis Micae Aureus 2.5-3.5, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4.5-5.5, Herba Hedyotidis Diffusae 6-9, Shishou Air Bladder pseudosciaenae seu Acipenser 5-8.

Be more preferably, Scorpio 15, Haematitum 10, Fructus Bruceae 12, Borax 4, Herba Catharanthi Rosei 3, Catharsii molossi 15, Radix Tripterygii Wilfordii 12, Radix Puerariae 30, Radix Patriniae heterophyllae 12, Lapis Micae Aureus 3, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5, Herba Hedyotidis Diffusae 7.5, Shishou Air Bladder pseudosciaenae seu Acipenser 6.5.

Esophageal carcinoma treating the poisonous disease with poisonous drugs preparation, be made into pharmaceutically acceptable pill, preparation method is

(1) Radix Tripterygii Wilfordii yellow mud (with 10% saline and loess in 1:4 ratio and even) is evenly wrapped up, put in microwave oven and concoct 10-20 minute under 40% power, take out, chopping, then uses 8-12 times amount ethanol (preferably adding the ethanol of 10 times amount) reflux, extract, 2 times, first time extracts 1-2 hour (preferably first time extracts 1.5 hours), second time is extracted 0.5-1.5 hour (preferably second time is extracted 1 hour), is merged by extracting solution, concentrated, evaporated under reduced pressure, obtains Radix Tripterygii Wilfordii extract; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) Radix Patriniae heterophyllae is cleaned and is placed in medicinal cupping, adds the rice-washed water of 4-8 times amount, at 60-70 DEG C, soaks 2-6 hour, takes out Radix Patriniae heterophyllae, dries 4-8 hour, grind into powder for subsequent use at 120 DEG C; Haematitum is put in iron pan and is covered tightly, and forge red with charcoal fire, taking-up lets cool, and is ground into fine powder; Get clean Borax, pulverize into powder, put in pot, heat with high heat, fry to heave little soak snow-white join pine bulk, take out, cool, levigation is for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drains, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use;

(3) Catharsii molossi removes foot, wing, is placed in iron pan, and low baking temperature dries, levigation; Lapis Micae Aureus removing impurity, smash to pieces, the Sal Nitri adding equivalent is mixed thoroughly, is calcined to is popular in method of close calcination, and cold rear taking-up, is ground into powder, with elutriation removing Sal Nitri, dry, then is ground into superfine powder; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 4-8 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

(4) by step (1) gained Radix Tripterygii Wilfordii extract and Fructus Bruceae powder, step (2) gained Radix Patriniae heterophyllae powder, Haematitum stone powder, Borax powder and Shishou Air Bladder pseudosciaenae seu Acipenser powder and step (3) gained Catharsii molossi powder and the mixing of Lapis Micae Aureus powder, sieve, obtain mixing fine powders;

(5) Scorpio, Radix Puerariae is got, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae are placed in medicinal cupping, add 6-8 times amount clear water (preferably adding 7 times amount clear water) and soak 60-120 minute, then add the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after step (3) process, intense fire boils fire of larding speech with literary allusions and endures 1-2 hour slowly, filter, filtrate reduced in volume becomes paste, adds step (4) gained mixing fine powders while hot, stirs, with water pill, to obtain final product.

The preparation method of above-mentioned esophageal carcinoma treating the poisonous disease with poisonous drugs pill, preferred scheme is, in step (1), the mass concentration of added ethanol is the mass concentration of the preferred added ethanol of 65%-85%(is 70%-80%, and the mass concentration of the added ethanol be more preferably is 75%).

The preparation method of above-mentioned esophageal carcinoma treating the poisonous disease with poisonous drugs pill, preferred scheme is, dries 5-7 hour (preferably 120 DEG C at dry 6 hours) in step (2) at 120 DEG C.

The preparation method of above-mentioned esophageal carcinoma treating the poisonous disease with poisonous drugs pill, preferred scheme is, the middle 40-80 mesh sieve excessively of step (4) (preferred 50-70 mesh sieve excessively, mistake 60 mesh sieve be more preferably).

Esophageal carcinoma treating the poisonous disease with poisonous drugs medicament, be made into pharmaceutically acceptable decoction, preparation method is:

(1) Radix Tripterygii Wilfordii yellow mud (with 10% saline and loess in 1:4 ratio and even) is evenly wrapped up, put in microwave oven and concoct 15-30 minute under 40% power, take out, chopping, then the ethanol of 8-10 times amount 70% (preferably adding the ethanol of 70% of 9 times amount) reflux, extract, 2 times are used, first time extracts 1.2-1.8 hour (preferably first time extracts 1.5 hours), second time is extracted 0.8-1.2 hour (preferably second time is extracted 1 hour), extracting solution is merged, concentrated, evaporated under reduced pressure, obtains Radix Tripterygii Wilfordii extract; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) Radix Patriniae heterophyllae is cleaned and is placed in medicinal cupping, adds the rice-washed water of 4-8 times amount, soaks 2-6 hour (soaking 4 hours at being preferable over 60-70 DEG C), take out Radix Patriniae heterophyllae, dry 4-8 hour, grind into powder for subsequent use at 120 DEG C at 60-70 DEG C; Haematitum is put in iron pan and is covered tightly, and forge red with charcoal fire, taking-up lets cool, and is ground into fine powder; Get clean Borax, pulverize into powder, put in pot, heat with high heat, fry to heave little soak snow-white join pine bulk, take out, cool, levigation is for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drains, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use;

(4) by step (1) gained Radix Tripterygii Wilfordii extract and Fructus Bruceae powder, step (2) gained Radix Patriniae heterophyllae powder, Haematitum stone powder, Borax powder and Shishou Air Bladder pseudosciaenae seu Acipenser powder and step (3) gained Catharsii molossi powder and the mixing of Lapis Micae Aureus powder, cross 70 mesh sieves, obtain mixing fine powders, be placed in penetrating bag for subsequent use;

(5) get Scorpio, Radix Puerariae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae are placed in medicinal cupping, add cold water and cover powder, soak 1-1.5 hour, then add water and do not have powder about 5 centimetres, add step (4) gained mixing fine powders and decoct; Intense fire is adopted to decoct at a simmer, with slow fire boiling 20-30 minute after boiling; Second decocts, and adds water and does not have powder about 4 centimetres, decoct 15-20 minute after water boils, and decocts extracting juice twice, merges, obtain decoction.

Esophageal carcinoma treating the poisonous disease with poisonous drugs medicament, be made into pharmaceutically acceptable powder, preparation method is:

(3) Catharsii molossi removes foot, wing, is placed in iron pan, and low baking temperature dries, levigation; Lapis Micae Aureus removing impurity, smash to pieces, the Sal Nitri adding equivalent is mixed thoroughly, is calcined to is popular in method of close calcination, and cold rear taking-up, is ground into powder, with elutriation removing Sal Nitri, dry, then is ground into superfine powder; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 4-8 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, grind into powder, for subsequent use;

(4) get Scorpio, Radix Puerariae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae are cleaned, and dry, and grinding, mixes with step (1)-(3) gained fine powder, mix thoroughly, subpackage, obtain powder.

Esophageal carcinoma treating the poisonous disease with poisonous drugs medicament, be made into pharmaceutically acceptable thick paste agent, preparation method is:

(1) Radix Tripterygii Wilfordii yellow mud (with 10% saline and loess in 1:4 ratio and even) is evenly wrapped up, put in microwave oven and concoct 15-30 minute under 40% power, take out, chopping, then uses the ethanol of 8-10 times amount 70% (preferably adding the ethanol of 70% of 9 times amount) reflux, extract, 2 times, first time extracts 1.8 hours, second time is extracted 1.2 hours, is merged by extracting solution, concentrated, evaporated under reduced pressure, obtains Radix Tripterygii Wilfordii extract; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) Radix Patriniae heterophyllae is cleaned and is placed in medicinal cupping, adds the rice-washed water of 4-8 times amount, soaks 3-6 hour (soaking 4.5 hours at being preferable over 60-70 DEG C), take out Radix Patriniae heterophyllae, dry 7 hours, grind into powder for subsequent use at 120 DEG C at 60-70 DEG C; Haematitum is put in iron pan and is covered tightly, and forge red with charcoal fire, taking-up lets cool, and is ground into fine powder; Get clean Borax, pulverize into powder, put in pot, heat with high heat, fry to heave little soak snow-white join pine bulk, take out, cool, levigation is for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drains, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use;

(3) Catharsii molossi removes foot, wing, is placed in iron pan, and low baking temperature dries, levigation; Lapis Micae Aureus removing impurity, smash to pieces, the Sal Nitri adding equivalent is mixed thoroughly, is calcined to is popular in method of close calcination, and cold rear taking-up, is ground into powder, with elutriation removing Sal Nitri, dry, then is ground into superfine powder; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift (preferably the clear water leaching drift of raw product 6 times amount) of 4-8 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

(4) by step (1) gained Radix Tripterygii Wilfordii extract and Fructus Bruceae powder, step (2) gained Radix Patriniae heterophyllae powder, Haematitum stone powder, Borax powder and Shishou Air Bladder pseudosciaenae seu Acipenser powder and step (3) gained Catharsii molossi powder and the mixing of Lapis Micae Aureus powder, cross 60 mesh sieves, obtain mixing fine powders, be placed in penetrating bag for subsequent use;

(5) get Scorpio, Radix Puerariae, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae are placed in medicinal cupping, add cold water and cover powder, soak 1-1.5 hour, then add water and do not have powder about 5 centimetres, add step (4) gained mixing fine powders and decoct; Intense fire is adopted to decoct at a simmer, with slow fire boiling 20-30 minute after boiling; Second decoct, add water and no powder about 4 centimetres, after water boils, decoct 15-20 minute, twice decoct extracting juice, merge, being evaporated to relative density is 1.35(75 DEG C) thick paste, sterilizing, encapsulate, to obtain final product.

Esophageal carcinoma treating the poisonous disease with poisonous drugs drug prescription science provided by the invention, preparation method is simple, products obtained therefrom taking convenience, evident in efficacy.In addition, excellent results of the present invention also shows:

1,the present invention mainly adopts pure Chinese medicinal preparation, medicine directly acts on cancerous issue, make effective ingredient can arrive focus rapidly, improve the availability of medicine, effectively can kill the growth of cancerous cell and anticancer, and prevent cancerous cell from spreading, thus play the effect of inhibition tumor cell growth and transfer.

2,products obtained therefrom of the present invention has dredging esophagus, stopping nausea and vomiting by lowering the adverse flow of QI, removing toxic substances of reducing phlegm, alleviating pain, presses down the effect that cancer is anticancer, strengthen immunity, extending life, is mainly used in the esophageal carcinoma.

3,medication effect of the present invention is good, taking convenience, and action effect is remarkable.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Herba Catharanthi Rosei: base is former: be Apocynaceae periwinkle plant Herba Catharanthi Rosei, the herb of yellow Herba Catharanthi Rosei.Composition: plant containing indoles alkaloid more than 70 in Herba Catharanthi Rosei, comprise vinblastine, vincristine, lochnericine, lochnericine, remove acetyl vindorosine, vincaleucoblastine, Changchun Buddhist nun is fixed, lochnerinine etc.Root containing alkaloid, comprises that 9-methoxycorynantheidine., akuammicine, west, Changchun are fixed, lochnerivine, cavineine sulfate, sulphuric acid stay around western language alkali, and ammocalline, sulphuric acid group is around raw etc.Pharmacology: 1. antitumor action Herba Catharanthi Rosei contains vinblastine, vincristine, leurosine, leurosidine have obvious antitumor action.2. Antitumor Mechanism Herba Catharanthi Rosei antitumor action is directly relevant to the high-affinity of tubulin binding with medicine, suppress nucleic acid synthesis be it another mechanism.No matter 3. blood pressure lowering and vasodilative effect catharanthus roseus total alkaloids gavage, intramuscular injection or quiet note all have hypotensive effect to anesthetized dog, also has the effect of expansion coronary vasodilator.4. the water extract of blood sugar lowering and effect for reducing blood fat this product leaf has normal or alloxan diabetes rabbit and dog and reduces blood glucose effect.The property of medicine: bitter, cold, poisonous.Function cures mainly: detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver.Cure mainly multiple cancerous protuberance, hypertension, carbuncle sore tumefacting virus, scald.

Scorpio: base is former: be the dry Scorpio of Buthidae animal Scorpio.Chemical analysis: containing scorpion venom is the Neurotoxic protein of a kind of similar snake venom.In addition, and containing trimethylamine, betanin, taurine, palmitic acid, stearic acid, cholesterol, lecithin and ammonium salt etc.Pharmacological action: 1. anticonvulsant action, 2. to the effect of cardiovascular system, toxicity: scorpion venom Main Function is for making respiratory paralysis, and its minimum lethal dose is 0.07 to rabbit, and mice is 0.5, and the frog is 0.7 mg/kg.Rabbit poisoning symptom is orthocolosis spasm, sialorrhea, respiratory arrest, and blood pressure rises, and the frog then sees extremity fibroid contracture, and mice is extremity and respiratory paralysis after excitatory state then.Scorpion venom is without haemolysis and Blood clotting.There is inhibitory action to isolated frog heart, have contraction to frog hind leg blood vessel, excitement is to isolated rabbit intestinal and frog bladder.Nature and flavor: salty pungent are flat, poisonous.Gui Jing: " guiding principle day ": " meridian of Foot-JUE YIN." function cures mainly: dispel the wind, relieving convulsion, dredging collateral, removing toxic substances.Control infantile convulsion to take out and pluck, epilepsy, apoplexy, hemiplegia, facial hemiparalysis, migraine, rheumatic arthralgia, tetanus, tuberculous lymphadenitis, rubella skin ulcer swells.

Haematitum: base is former: be the Ore of oxide-based mineral bloodstone.Chemical analysis: main containing iron sesquioxide, wherein ferrum 70%, oxygen 30%, sometimes impure titanium, magnesium, aluminum, silicon and moisture.Nature and flavor: bitter, sweet, flat.Gui Jing: return liver, stomach, heart born of the same parents warp.Function cures mainly: suppressing the hyperactive liver town is inverse, cooling blood for hemostasis.Control eructation vomiting, dysphagia and regurgitation, asthma, infantile convulsion, spit blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, bleeding not during menses.

Borax: base is former: for mineral Borax is through refining crystallization.Chemical analysis: be sodium tetraborate.Pharmacological action: be a weak base, the same with boric acid have weak bacteriostasis.The Borax containing 10% in culture medium is made by flat band method, all there is inhibitory action to escherichia coli, bacillus pyocyaneus, anthrax bacillus, bacterium flexneri, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, Bacillus proteus and staphylococcus, Candida albicans, prove that Borax can also suppress diphtheria corynebacterium, cattle type Brucella, Diplococcus pneumoniae, meningococcus and Hemolytic streptococcus etc. with paper disk method.In order to rinse ulcer, abscess, particularly mucosa irritation, as conjunctivitis, gastritis etc., because it is alkalescence, can make mucosa de-sludging, oral for urethra sterilization, special urine, for time acid, can make it alkalize.Nature and flavor: Gan Xian are cool.Gui Jing: enter lung, stomach warp.Function cures mainly: heat clearing away expectorant, detoxifies anticorrosion.Control laryngopharynx swelling and pain, aphtha of the mouth and tongue, cataract, bone is choked, dysphagic, and cough expectorant is thick.

Catharsii molossi: base is former: be the dry Scorpio of Scarabaeidae insecticide Shi Ge dung beetle.Chemical analysis: containing toxic component about 1%.Working substance mass-energy is water-soluble, ethanol and chloroform, but is insoluble to ether.Pharmacological action: Catharsii molossi toxin.After being injected in white mice, performance is uneasy, because convulsion is lethal after several tens minutes; Intravenous injection is after rabbit, and blood pressure declines for the moment, rises immediately, and breathe amplitude and increase, frequency is accelerated; There is inhibitory action to Bufo siccus isolated heart, be poured into the hind leg blood vessel of Bufo siccus, have temporary transient dilating effect; There is inhibitory action to rabbit intestinal tube and uterus, have paralysis effect to the neuromuscular specimen of Bufo siccus.Nature and flavor: salty, cold, poisonous.Gui Jing: " detailed outline ": " hands, foot sun are bright, the moon of fainting enough." function cures mainly: arresting convulsion, removing blood stasis with potent drugs, relieving constipation, counteracting toxic substances.Control infantile convulsion, demented, lump in the abdomen, dysphagia and regurgitation, abdominal distention constipation, gonorrhea, infantile malnutrition, dysentery, anal fistula, furuncle swells, malignant boil.

Radix Tripterygii Wilfordii: base is former: be root, the Ye Jihua of Celastraceae plant Radix Tripterygii Wilfordii.Chemical analysis: root throws away the alkaloids such as alkali, wilforgine, wilfortrine and wilfozine containing wilfordine, Radix Tripterygii Wilfordii.Pharmacological action: insecticidal action: the infusion of Radix Tripterygii Wilfordii and ethanol immersion all have the ability of poisoning Folium pyri star caterpillar and leaf folder; But its petroleum ether, ether or three oxygen methane immersion, then there is no killing ability.Toxicity: Radix Tripterygii Wilfordii is different to various animal toxicity, it is very large to the toxicity of people, dog, pig and insecticide, can occur poisoning even dead, but to sheep, rabbit, cat, Mus, fish but avirulence.The effect of Radix Tripterygii Wilfordii to body has two: one for the stimulation to gastrointestinal tract local; Two is the infringement to central nervous system (comprising Thalamus, midbrain, oblongata, cerebellum and spinal cord) after absorption, and causes the hemorrhage and necrosis of liver, the heart.Have meaning Radix Tripterygii Wilfordii mainly to poison the heart of animal, but to other smooth muscle and striped muscle also toxic, this is poisoning lethal reason.Poisoning rear emergency treatment is the conventional methods such as emetic, gastric lavage, coloclysis, catharsis, utilizes detoxification biology of Sanguis caprae seu ovis or rabbit stomach leachate not yet to determine.The toxic component of Radix Tripterygii Wilfordii can leach with ether, but through reduction, toxicity disappears completely.Nature and flavor: " Hunan medicine will ": " bitter, poison greatly." function cures mainly: " Hunan medicine will ": " parasite killing, antiinflammatory, removing toxic substances.”

Radix Puerariae: base is former: this product is the dry root of legume pueraria lobata.Character: this product is rectangle sheet or the blockage of rip cutting.Crust light brown, has vertical wrinkle, coarse.Tangent plane yellow-white, texture is not obvious.Matter is tough, and fibroid is strong.Nature and flavor: sweet, pungent, cool.Gui Jing: return spleen, stomach warp.Effect: expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.Cure mainly: for fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.

Radix Patriniae heterophyllae: base is former: be the root of Valerianaceae plant Radix Patriniae Scabrae, Radix Patriniae Scabrae.Pharmacological action: Radix Patriniae heterophyllae preparation, through preliminary test, has suppression and injury effect in vitro to ehrlich carcinoma cell; Oral to suffering from Ehrlich ascites carcinoma, to the injection of Emhorn solid carcinoma mouse peritoneal or this preparation of subcutaneous injection, also there is certain curative effect.Nature and flavor: " Guangxi Chinese medicinal herbal ": " acrid in the mouth, warm in nature." return through " Guangxi Chinese medicinal herbal ": " enter the heart, liver two warp." function cures mainly: control pyrexial malaria, women's metrorrhagia, leucorrhea with red and white discharge, traumatic injury.

Lapis Micae Aureus: base is former: be stone or the particle of metamorphic rock rocks chlorite schist or mica schist.Chemical analysis: Lapis Chloriti main component is magnesium, aluminum, ferrum, silicic acid and water of crystallization is a kind of hydrosilicate mineral being similar to Muscovitum.Cause containing the low ferrum showing amount, therefore is often green.Nature and flavor: salty are flat.Gui Jing: enter liver, lung, stomach warp.Function cures mainly: pendant expectorant, helps digestion, the therapeutic method to keep the adverse QI flowing downwards, suppressing the hyperactive liver.Control the pertinacious phlegm hypochondriac lump, dyspepsia lump in the abdomen, demented infantile convulsion, cough dyspnea with rapid respiration, sputum is stopped up.

Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): base is former: be the tuber of ranunculaceae plant Aconitum kongboense Lauener.Nature and flavor: warm in nature, bitter in the mouth fiber crops, very toxic.Function cures mainly: anti-inflammatory analgetic, expelling wind and removing dampness.

Herba Hedyotidis Diffusae: base is former: be the whole herb with root of Radix Rubiae kind of plant Herba Hedyotidis Diffusae.Chemical analysis: separate 1 alkane, stigmasterol, ursolic acid, oleanolic acid in herb, cupreol, cupreol-D-Glucose glycoside, P-coumaric acid etc.Pharmacological action: 1. antitumor action, 2. antibacterial, antiinflammation, nature and flavor: bitter sweet, cold.Nature and flavor: bitter sweet, cold.Function cures mainly: heat clearing away, dampness removing, removing toxic substances.Control dyspnea and cough due to lung-heat, tonsillitis.Pharyngolaryngitis, appendicitis, dysentery, urinary tract infection, jaundice, hepatitis, pelvic inflammatory disease, adnexitis, carbuncle furuncle, venom, tumor.Also can be used for alimentary tract cancer.

Shishou Air Bladder pseudosciaenae seu Acipenser: base is former: be the Air Bladder pseudosciaenae seu Acipenser of Sciaenidae animal Carnis Pseudosciaenae or Carnis Pseudosciaenae.Nature and flavor: sweet are flat.Gui Jing: " book on Chinese herbal medicine is newly organized ": " enter kidney." function cures mainly: the kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, dissipating blood stasis, detumescence.Control spermatorrhea of suffering from a deficiency of the kidney, puerperal puerperal tetanus, tetanus, spit blood, metrorrhagia, wound hemorrhage, hemorrhoid.

embodiment 1esophageal carcinoma treating the poisonous disease with poisonous drugs medicament, is prepared from by following bulk drugs, is weight portion: Scorpio 10g, Haematitum 8g, Fructus Bruceae 9g, Borax 3g, Herba Catharanthi Rosei 2g, Catharsii molossi 10g, Radix Tripterygii Wilfordii 9g, Radix Puerariae 20g, Radix Patriniae heterophyllae 8g, Lapis Micae Aureus 2g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4g, Herba Hedyotidis Diffusae 5g, Shishou Air Bladder pseudosciaenae seu Acipenser 4g.

The preparation method of above-mentioned esophageal carcinoma treating the poisonous disease with poisonous drugs pill is:

(1) Radix Tripterygii Wilfordii yellow mud (with 10% saline and loess in 1:4 ratio and even) is evenly wrapped up, put in microwave oven and concoct 10-20 minute under 40% power, taking out, chopping, is then 65% alcohol reflux 2 times by 8 times amount mass concentrations, first time extracts 1 hour, second time is extracted 0.5 hour, is merged by extracting solution, concentrated, evaporated under reduced pressure, obtains Radix Tripterygii Wilfordii extract; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) Radix Patriniae heterophyllae is cleaned and is placed in medicinal cupping, adds the rice-washed water of 4-8 times amount, at 60-70 DEG C, soaks 2-6 hour, takes out Radix Patriniae heterophyllae, dries 4 hours, grind into powder for subsequent use at 120 DEG C; Haematitum is put in iron pan and is covered tightly, and forge red with charcoal fire, taking-up lets cool, and is ground into fine powder; Get clean Borax, pulverize into powder, put in pot, heat with high heat, fry to heave little soak snow-white join pine bulk, take out, cool, levigation is for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drains, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use;

(4) by step (1) gained Radix Tripterygii Wilfordii extract and Fructus Bruceae powder, step (2) gained Radix Patriniae heterophyllae powder, Haematitum stone powder, Borax powder and Shishou Air Bladder pseudosciaenae seu Acipenser powder and step (3) gained Catharsii molossi powder and the mixing of Lapis Micae Aureus powder, cross 100 mesh sieves, obtain mixing fine powders;

(5) Scorpio, Radix Puerariae is got, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae are placed in medicinal cupping, add 6 times amount clear water and soak 60-120 minute, then add the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after step (3) process, intense fire boils fire of larding speech with literary allusions and endures 1-2 hour slowly, filter, filtrate reduced in volume becomes paste, adds step (4) gained mixing fine powders while hot, stirs, with water pill, to obtain final product.

The instructions of taking of pill of the present invention is: twice daily, each 2-4 ball, and 20 days courses for the treatment of, period in a medicine avoids maror.

Typical case: in XX, man, 56 years old, retired worker.In October, 2009 examination in hospital be diagnosed as in esophago mesomere cancer, late period.Hospitalization, effect is undesirable, and rear certain Army Hospital that turns treats, and health is too poor, does not feel any better.Carried out here diagnosis and treatment upon somebody's introduction afterwards, checked: patient's dysphagia, food must not under, under drinking-water difficulty, food youngster vomiting usually, dim complexion, body is thin as material, and defecation is difficult to resolve, and tripe is swollen as roused.

Take the present embodiment gained esophageal carcinoma treating the poisonous disease with poisonous drugs pill, after the course for the treatment of, tripe is swollen to disappear, pain relief; After two courses for the treatment of of medication, the state of an illness takes a favorable turn, and can drink gruel, and defecate unimpeded, health progressively recovers, and check again four courses for the treatment of of treatment, focus disappears substantially, and cancerous cell is controlled, and part cancerous cell disappears.Present patient body is in good condition.

embodiment 2esophageal carcinoma treating the poisonous disease with poisonous drugs medicament, is prepared from by following bulk drugs, is weight portion: Scorpio 20g, Haematitum 12g, Fructus Bruceae 15g, Borax 5g, Herba Catharanthi Rosei 4g, Catharsii molossi 20g, Radix Tripterygii Wilfordii 15g, Radix Puerariae 40g, Radix Patriniae heterophyllae 16g, Lapis Micae Aureus 4g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 6g, Herba Hedyotidis Diffusae 10g, Shishou Air Bladder pseudosciaenae seu Acipenser 9g.

The preparation method of above-mentioned esophageal carcinoma treating the poisonous disease with poisonous drugs decoction is:

(1) Radix Tripterygii Wilfordii yellow mud (with 10% saline and loess in 1:4 ratio and even) is evenly wrapped up, put in microwave oven and concoct 15-30 minute under 40% power, take out, chopping, then use the alcohol reflux 2 times of 9 times amount 70%, first time extracts 1.5 hours, second time is extracted 1 hour, is merged by extracting solution, concentrated, evaporated under reduced pressure, obtains Radix Tripterygii Wilfordii extract; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) Radix Patriniae heterophyllae is cleaned and is placed in medicinal cupping, adds the rice-washed water of 4-8 times amount, soaks 4 hours at 60-70 DEG C, takes out Radix Patriniae heterophyllae, dries 4-8 hour, grind into powder for subsequent use at 120 DEG C; Haematitum is put in iron pan and is covered tightly, and forge red with charcoal fire, taking-up lets cool, and is ground into fine powder; Get clean Borax, pulverize into powder, put in pot, heat with high heat, fry to heave little soak snow-white join pine bulk, take out, cool, levigation is for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drains, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use;

The instructions of taking of decoction of the present invention is: once a day, each 150-200 milliliter, and 20 days courses for the treatment of, period in a medicine avoids maror.

Typical case: Liu XX, man, 46 years old, certain company manager.Patient from 2010 examination in hospital be diagnosed as the esophageal carcinoma early, mid-term.In local hospital treatment, before treatment, patient Shang Ke drinks water, and enters rare food, but by after Radiotherapy chemotherapy, body immunity declines, and more than the treatment moon, disease does not only take a turn for the better and increases the weight of on the contrary, has a meal and feels very difficult, introduces afterwards through friend, carrys out here treatment.Check: chest and diaphragm pain increases the weight of, constipation, urine amount is few, and red tongue with a little fluid, thready and hesitant pulse, red tongue, tongue is micro-greasy, thready and rolling pulse.

Take the present embodiment gained esophageal carcinoma treating the poisonous disease with poisonous drugs decoction, treat a course for the treatment of, the state of an illness take a favorable turn, and can drink water, eat dish feed also smoothly, do not vomit, pain uncomfortable in chest disappears substantially, in June, 2012 checks to hospital, and result is that cancerous cell suppresses, and most of cancerous cell is killed.Follow up a case by regular visits to so far, patient body in order.

embodiment 3esophageal carcinoma treating the poisonous disease with poisonous drugs medicament, is prepared from by following bulk drugs, is weight portion: Scorpio 14g, Haematitum 9g, Fructus Bruceae 11g, Borax 3.5g, Herba Catharanthi Rosei 2.5g, Catharsii molossi 14g, Radix Tripterygii Wilfordii 11g, Radix Puerariae 25g, Radix Patriniae heterophyllae 10g, Lapis Micae Aureus 2.5g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4.5g, Herba Hedyotidis Diffusae 6g, Shishou Air Bladder pseudosciaenae seu Acipenser 5g.

The preparation method of above-mentioned esophageal carcinoma treating the poisonous disease with poisonous drugs powder is:

The instructions of taking of powder of the present invention is: every day 3 times, and each 1 bag, 20 days courses for the treatment of, period in a medicine avoids maror.

Typical case: Cao XX, 62 years old, people from Liaoning.In March, 2011 is diagnosed as advanced esophageal carcinoma at local people's examination in hospital, hospitalization, and the state of an illness does not take a turn for the better, and some increases the weight of on the contrary, can also eat general diet when originally entering institute, and chest starts not ache, and some pain, leaves hospital then now.Introduced here treatment through ward mate afterwards.Check: dysphagia, inappetence, mouth gushes foam, sensation of oppression over the chest with shortness of breath, neurolysis, pale tongue with white fur, thready and weak pulse.

Take the present embodiment gained esophageal carcinoma treating the poisonous disease with poisonous drugs powder, after treating a course for the treatment of, the state of an illness takes a favorable turn, chest pain disappears, diet is swallowed relatively more smooth, after treating two courses for the treatment of, and patient mental's recovering state, defecation is unobstructed, after checking three courses for the treatment of of treatment again, patient's cancerous cell controls, and nowadays health is good.

embodiment 4esophageal carcinoma treating the poisonous disease with poisonous drugs medicament, is prepared from by following bulk drugs, is weight portion: Scorpio 16g, Haematitum 11g, Fructus Bruceae 13g, Borax 4.5g, Herba Catharanthi Rosei 3.5g, Catharsii molossi 16g, Radix Tripterygii Wilfordii 13g, Radix Puerariae 35g, Radix Patriniae heterophyllae 14g, Lapis Micae Aureus 3.5g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5.5g, Herba Hedyotidis Diffusae 9g, Shishou Air Bladder pseudosciaenae seu Acipenser 8g.

The preparation method of above-mentioned esophageal carcinoma treating the poisonous disease with poisonous drugs thick paste agent is:

(1) Radix Tripterygii Wilfordii yellow mud (with 10% saline and loess in 1:4 ratio and even) is evenly wrapped up, put in microwave oven and concoct 15-30 minute under 40% power, take out, chopping, then use ethanol 9 reflux, extract, 2 times of 9 times amount 70%, first time extracts 1.8 hours, second time is extracted 1.2 hours, is merged by extracting solution, concentrated, evaporated under reduced pressure, obtains Radix Tripterygii Wilfordii extract; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) Radix Patriniae heterophyllae is cleaned and is placed in medicinal cupping, adds the rice-washed water of 4-8 times amount, soaks 4.5 hours at 60-70 DEG C, takes out Radix Patriniae heterophyllae, dries 7 hours, grind into powder for subsequent use at 120 DEG C; Haematitum is put in iron pan and is covered tightly, and forge red with charcoal fire, taking-up lets cool, and is ground into fine powder; Get clean Borax, pulverize into powder, put in pot, heat with high heat, fry to heave little soak snow-white join pine bulk, take out, cool, levigation is for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drains, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use;

(3) Catharsii molossi removes foot, wing, is placed in iron pan, and low baking temperature dries, levigation; Lapis Micae Aureus removing impurity, smash to pieces, the Sal Nitri adding equivalent is mixed thoroughly, is calcined to is popular in method of close calcination, and cold rear taking-up, is ground into powder, with elutriation removing Sal Nitri, dry, then is ground into superfine powder; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the raw product clear water leaching drift of 6 times amount, until in soft-hearted after cut into slices, put in food steamer and steam, be placed in 95 DEG C of baking ovens and dry, then mix thoroughly with lard stearin, fry, dry in the air cool for subsequent use;

The instructions of taking of thick paste agent of the present invention is: twice daily, each 1-2 spoon, warm boiled water, and 20 days courses for the treatment of, period in a medicine avoids maror.

Typical case: Lee XX, female, 51 years old, people from Shandong, in May, 2010, because swallowing food difficulty, vomiting, to local people hospital through the diagnosis of X-ray barium meal, was diagnosed as esophageal carcinoma mid-term.Long 5.6 centimetres of Upper Esophageal Carcinoma, body is weak, can not perform the operation and go home.After one month, patient feels suffocating pain over the chest, dysphagia, abdominal distention, can only eat by influent stream, aggravation.To get off here diagnosis and treatment in the introduction of relative, check: patient feels run-down, diet pain, and soup can enter, dry mouth and throat, emaciated physique, red tongue with a little fluid, thready and hesitant pulse.

Take the agent of this enforcement gained esophageal carcinoma treating the poisonous disease with poisonous drugs thick paste, after the course for the treatment of, patient's subjective symptoms is clearly better, and body weight obviously increases, antisecosis.After taking two courses for the treatment of, patient can enter a small amount of food, abdominal distention, disappearance uncomfortable in chest, after adhere to again taking three courses for the treatment of, patient's cancerous cell is controlled, and part cancerous cell is killed, and follows up a case by regular visits to so far, patient body in order, without recurrence.

embodiment 5esophageal carcinoma treating the poisonous disease with poisonous drugs medicament, is prepared from by following bulk drugs, is weight portion: Scorpio 15g, Haematitum 10g, Fructus Bruceae 12g, Borax 4g, Herba Catharanthi Rosei 3g, Catharsii molossi 15g, Radix Tripterygii Wilfordii 12g, Radix Puerariae 30g, Radix Patriniae heterophyllae 12g, Lapis Micae Aureus 3g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5g, Herba Hedyotidis Diffusae 7.5g, Shishou Air Bladder pseudosciaenae seu Acipenser 6.5g.

(1) Radix Tripterygii Wilfordii yellow mud (with 10% saline and loess in 1:4 ratio and even) is evenly wrapped up, put in microwave oven and concoct 10-20 minute under 40% power, taking out, chopping, is then the alcohol reflux 2 times of 75% by 10 times amount mass concentrations, first time extracts 1.5 hours, second time is extracted 1 hour, is merged by extracting solution, concentrated, evaporated under reduced pressure, obtains Radix Tripterygii Wilfordii extract; Fructus Bruceae is cleaned, and dry, peel off shell, round core, low baking temperature dries, and grinds into powder for subsequent use;

(2) Radix Patriniae heterophyllae is cleaned and is placed in medicinal cupping, adds the rice-washed water of 4-8 times amount, at 60-70 DEG C, soaks 2-6 hour, takes out Radix Patriniae heterophyllae, dries 6 hours, grind into powder for subsequent use at 120 DEG C; Haematitum is put in iron pan and is covered tightly, and forge red with charcoal fire, taking-up lets cool, and is ground into fine powder; Get clean Borax, pulverize into powder, put in pot, heat with high heat, fry to heave little soak snow-white join pine bulk, take out, cool, levigation is for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drains, explode to crisp with Oleum sesami, take out, be pressed into powder, put in cold-bottling for subsequent use;

(4) by step (1) gained Radix Tripterygii Wilfordii extract and Fructus Bruceae powder, step (2) gained Radix Patriniae heterophyllae powder, Haematitum stone powder, Borax powder and Shishou Air Bladder pseudosciaenae seu Acipenser powder and step (3) gained Catharsii molossi powder and the mixing of Lapis Micae Aureus powder, cross 120 mesh sieves, obtain mixing fine powders;

(5) Scorpio, Radix Puerariae is got, Herba Catharanthi Rosei and Herba Hedyotidis Diffusae are placed in medicinal cupping, add 7 times amount clear water and soak 60-120 minute, then add the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) after step (3) process, intense fire boils fire of larding speech with literary allusions and endures 1-2 hour slowly, filter, filtrate reduced in volume becomes paste, adds step (4) gained mixing fine powders while hot, stirs, with water pill, to obtain final product.

test example 1the applied research of embodiment 5 gained esophageal carcinoma treating the poisonous disease with poisonous drugs pill:

1. clinical data

1.1 case selection

In July, 2009, in December ,-2011, screened 296 routine patient with esophageal carcinoma 4 oncology sections of hospital, wherein male 172 example, women 124 example, the age 38-71 year, 46.5 ± 3.2 years old mean age.In all patients, early stage patient 106 example, mid-term, patient with esophageal carcinoma 110 was routine, late esophagus cancer patient 80 example.

1.2 diagnostic criteria

With the foundation being diagnosed as case observation of hospital above the provincial level, the diagnostic criteria of several malignant tumor that the diagnosis compound health ministry observing case is formulated.

(1) according to clinical symptoms, sign and imaging examination, meet following one and can be used as diagnostic criteria:

Swallow food to have and choke with sobs sense, foreign body sensation, retrosternal pain or occur obvious dysphagia, esophagogram finds that Esophageal Mucosa limitation increases the performances such as thick, local tube wall is stiff, and breast CT inspection finds that the annular of esophagus tube wall thickens or irregular thickening.

1.3 Therapeutic Method

All patients all take and are implemented example 5 gained esophageal carcinoma treating the poisonous disease with poisonous drugs pill, and instructions of taking is: twice daily, each 2-4 ball, and 20 days courses for the treatment of, period in a medicine avoids maror.Observe five courses for the treatment of of treatment altogether.

1.4 the standard of curative effect evaluation

Basic healing: tumor all disappears, Continuous Observation more than 3 years, without recurrence, can orthobiosis, work.

Effective: tumor regression is over half, and maintain more than 2 years persons; Patient can people's live and work as usual.

Effective: below tumor regression half, and maintain more than 1 year person;

Invalid: symptom is as treated front or increasing the weight of.

1.5 therapeutic outcome

Table 1 uses embodiment 5 product 38-71 year patient with esophageal carcinoma therapeutic outcome

In side, Haematitum cures mainly eructation vomiting, dysphagia and regurgitation; Borax external heat-clearing and toxic substances removing, subsides a swelling anticorrosion; Removing heat from the lung and dissipating phlegm for oral administration; Catharsii molossi has arresting convulsion, removing blood stasis with potent drugs, relieving constipation, the effect of counteracting toxic substances; Radix Tripterygii Wilfordii has parasite killing, antiinflammatory, effect of removing toxic substances; Radix Puerariae is used for fever caused by exogenous pathogens headache, stiff nape and back; Lapis Micae Aureus nature and flavor are salty, flat, cure mainly pendant expectorant, help digestion, the therapeutic method to keep the adverse QI flowing downwards, suppressing the hyperactive liver; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) anti-inflammatory analgetic, expelling wind and removing dampness; Shishou Air Bladder pseudosciaenae seu Acipenser the kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, dissipating blood stasis.The all medicines of we share, and can mutually adjust, treating the poisonous disease with poisonous drugs reaches the object of killing tumor cell.Total effective rate 97.6%.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims

1. esophageal carcinoma treating the poisonous disease with poisonous drugs medicament, is characterized in that: be prepared from by following bulk drugs, is weight portion: Scorpio 10-20, Haematitum 8-12, Fructus Bruceae 9-15, Borax 3-5, Herba Catharanthi Rosei 2-4, Catharsii molossi 10-20, Radix Tripterygii Wilfordii 9-15, Radix Puerariae 20-40, Radix Patriniae heterophyllae 8-16, Lapis Micae Aureus 2-4, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4-6, Herba Hedyotidis Diffusae 5-10, Shishou Air Bladder pseudosciaenae seu Acipenser 4-9.

2. esophageal carcinoma treating the poisonous disease with poisonous drugs medicament as claimed in claim 1, is characterized in that: be prepared from by following bulk drugs, is weight portion: Scorpio 14-16, Haematitum 9-11, Fructus Bruceae 11-13, Borax 3.5-4.5, Herba Catharanthi Rosei 2.5-3.5, Catharsii molossi 14-16, Radix Tripterygii Wilfordii 11-13, Radix Puerariae 25-35, Radix Patriniae heterophyllae 10-14, Lapis Micae Aureus 2.5-3.5, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4.5-5.5, Herba Hedyotidis Diffusae 6-9, Shishou Air Bladder pseudosciaenae seu Acipenser 5-8.

3. esophageal carcinoma treating the poisonous disease with poisonous drugs medicament as claimed in claim 1, is characterized in that: be prepared from by following bulk drugs, is weight portion: Scorpio 15, Haematitum 10, Fructus Bruceae 12, Borax 4, Herba Catharanthi Rosei 3, Catharsii molossi 15, Radix Tripterygii Wilfordii 12, Radix Puerariae 30, Radix Patriniae heterophyllae 12, Lapis Micae Aureus 3, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5, Herba Hedyotidis Diffusae 7.5, Shishou Air Bladder pseudosciaenae seu Acipenser 6.5.

4. the esophageal carcinoma treating the poisonous disease with poisonous drugs medicament as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is:

5. the preparation method of esophageal carcinoma treating the poisonous disease with poisonous drugs pill according to claim 4, it is characterized in that, in step (1), the mass concentration of added ethanol is the mass concentration of the preferred added ethanol of 65%-85%(is 70%-80%, and the mass concentration of the added ethanol be more preferably is 75%).

6. the preparation method of esophageal carcinoma treating the poisonous disease with poisonous drugs pill according to claim 4, is characterized in that, dries 5-7 hour (preferably 120 DEG C at dry 6 hours) in step (2) at 120 DEG C.

7. the preparation method of esophageal carcinoma treating the poisonous disease with poisonous drugs pill according to claim 4, is characterized in that, the middle 100-140 mesh sieve excessively of step (4) (preferred 110-130 mesh sieve excessively, mistake 120 mesh sieve be more preferably).

8. the esophageal carcinoma treating the poisonous disease with poisonous drugs medicament as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is:

9. the esophageal carcinoma treating the poisonous disease with poisonous drugs medicament as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable powder, preparation method is:

10. the esophageal carcinoma treating the poisonous disease with poisonous drugs medicament as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable thick paste agent, preparation method is: