CN107334902A - Treat Chinese medicine composition of digestive system tumor Postsurgical Gastroparesis and preparation method thereof - Google Patents
Treat Chinese medicine composition of digestive system tumor Postsurgical Gastroparesis and preparation method thereof Download PDFInfo
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- CN107334902A CN107334902A CN201710581323.8A CN201710581323A CN107334902A CN 107334902 A CN107334902 A CN 107334902A CN 201710581323 A CN201710581323 A CN 201710581323A CN 107334902 A CN107334902 A CN 107334902A
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Abstract
The invention provides a kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis and preparation method thereof, belong to technical field of traditional Chinese medicine preparation.A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, is made up of the raw material of following parts by weight：10 ~ 30 parts of cassia twig, 10 ~ 30 parts of Chinese yam, 5 ~ 20 parts of 5 ~ 20 parts of, Shuo Di of west safflower, 5 ~ 20 parts of Waternut Herb, 3 ~ 15 parts of pine mushroom, 3 ~ 15 parts of certain herbaceous plants with big flowers of match, 3 ~ 15 parts of the bighead atractylodes rhizome, 1 ~ 10 part of perilla leaf, 1 ~ 10 part of the root bark of shaggy-fruited dittany.The present invention by medicine coordinated, cures mainly the symptoms such as nauseous caused by digestive system tumor Postsurgical Gastroparesis, vomiting, early satiety, post-prandial fullness, abdominal distention, promotes digestion health, enhancing body immunity using theory of traditional Chinese medical science as guidance.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to a kind of Chinese medicine for treating digestive system tumor Postsurgical Gastroparesis
Composition and preparation method thereof.
Background technology
Digestive system tumor Postsurgical Gastroparesis is Post operation because gastrointestinal dysfunction causes gastric emptying non-with stomach efferent tract
Mechanical obstruction is the functional disease mainly showed.Its main clinic symptoms is that postoperative gastric drainage flow is more, duration length, evil
The heart, vomiting, early satiety, post-prandial fullness, abdominal distention etc., are the Short-term Complications after tumor operation.The hair of Gastroparesis syndrome at present
Life system is not fully understood, and research shows relevant with following reason：（1）The factor of Anxiety WeiDongLi Capsule, such as stomach efferent tract
Obstruction, Electrolyte imbalance, anaemia, Hypoproteinemia and diabetes etc.；（2）Vagus nerve loses, when Radical Operation of Gastric Carcinoma is cut off
Vagus nerve is damaged, destroys the neuromodulation of stomach；（3）Method of alimentary tract reconstruction, the reconstructions of intestines and stomach make gastric emptying in dissection and
Physiologically losing function of unity, Billroth's Ⅰ is closer to the physiological structure of stomach, and Billroth's Ⅱ subtotal gastrectomy is because the digestive juices such as bile enter residual stomach,
Can be disabled gastremia and previous anastomotic oedema, cause Gastroparesis syndrome incidence to dramatically increase；（4）Operation wound suppresses WeiDongLi Capsule,
Suppress smooth muscle contraction；（5）Stomach and intestine parahormone is secreted and function changes, and the hormone secretion such as postoperative gastrin and motilin is reduced,
And suppress the stomach and intestine parahormone secretion increase of residual gastric emptying.Specific considerations not sick to this in traditional Chinese medical science ancient Chinese prose, because its with it is swollen,
Completely, it is main clinical manifestation to tell and lose the appetite, and can be belonged to the categories such as the traditional Chinese medical science " feeling of fullness " " vomiting " " gasteremphraxis " " indigestion and loss of appetite ".
Treatment Postsurgical Gastroparesis Syndrome is without effective ways at present, more based on western medicine, more to promote digestive tract power reinforcing medicine
Based on thing, metoclopramide is dopamine receptor antagonist, promotes rapid gastric emptying, and Mosapride is potent, selective 5-HT4 acceptors
Activator, the release of acetylcholine can be promoted, stimulating gastrointestinal road and play small intestinal transit, so as to improve functional dyspepsia FD
The gastrointestinal symptom of patient.And the treatment of Postsurgical Gastroparesis Syndrome, be not merely gastroenteritic power recovery, even more digestive system is more
Organ cooperation can be only achieved functional recovery, therefore, simple western medical treatment slowly effect, course for the treatment of length, make patient by material
With the dual-pressure of spirit.
Ji Shimin etc.（The inverse Liqi Decoction of Ji Shimin, Li Wansheng, Zhao Bin drops is in treatment alimentary system malignant tumour Postsurgical Gastroparesis
Clinical research [J] China and foreign countries medical treatment of syndrome, 2017 (12)：175-179）The inverse Liqi Decoction of research drop is disliked in treatment digestive system
The effect of property tumor post-operation Gastroparesis syndrome.The drop converse theorem gas soup formula：Ginger 40g, pinellia 20g, bark of official magnolia 20g, dried orange peel
30g, the raw bighead atractylodes rhizome 30g, Poria cocos 30g, Radix Codonopsis 20g, wherein：Ginger cures mainly fullness sensation in chest cough with dyspnea, middle benefit gas, nourishing the stomach stopping nausea and vomiting by lowering the adverse flow of QI, temperature
Middleization drink is monarch drug in a prescription；The main hardness in the epigastrium of pinellia, lower gas, a dizzy chest is swollen, and cough the dead flesh of the raw main wind-cold-dampness arthralgia of the bighead atractylodes rhizome, changes water against borborygmus
It is wet, help digestion；The main chest side of body of Poria cocos ties pain against gas under the heart, fever and chills dysphoria, cough is inverse, drops inverse Li Shui, is ministerial drug；Radix Codonopsis removes middle burnt feeling of fullness
It is obstructed, go water to drink, body fluid complementing is adjutant, the bark of official magnolia, dried orange peel cold-dampness burnt in removing ' remove turgor, middle benefit gas qi-regulating, to make medicine, monarch
Minister assistant makes, and compatibility is precise and appropriate.Full side's composition drop converse theorem gas, changes water drink, controls regulating the function of middle-JIAO stomach Qi, and adjustment negative and positive lifting is burnt in recovery
The function of motion.The drop against Liqi Decoction to be administered orally, but for digestive system tumor Postsurgical Gastroparesis patient, its stomach function
Disorder, fasting water, decoction of medicinal ingredients treatment for oral administration can not be received mostly, therefore, the drop is limited against the applicable object of Liqi Decoction, and take effect compared with
Slowly.
Publication No. CN105169355A patent provides a kind of Chinese medicine group for treating digestive system tumor Postsurgical Gastroparesis
Compound and preparation method thereof, the Chinese medicine composition consist of the following composition：The banksia rose, cloves, Fructus Aurantii, the bark of official magnolia, rhizoma zingiberis, Chinese cassia tree,
Pangolin and scorpio.The invention uses the method for administration of acupoint application of Chinese herb, avoids the liver head that is administered orally and may occur
Effect and stomach and intestine inactivation are crossed, topically effective blood medicine is improved, according to the syndrome characteristics of stomach paralysis patient, to deficiency-cold in spleen and stomach, stagnation of the circulation of vital energy blood
The Gastroparesis syndrome patient of stasis syndrome, effect are better than prior art.The invention has the following disadvantages：Although the party uses external curing
Oral disadvantage is avoided, but for allergic or scytitis patient, then can not be applied.
The content of the invention
In view of this, the technical problems to be solved by the invention are to provide a kind of digestive system tumor Postsurgical Gastroparesis for the treatment of
Chinese medicine composition, it is evident in efficacy.
To achieve the above object, the technical solution adopted in the present invention is：
A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, is made up of the raw material of following parts by weight：Cassia twig 10 ~ 30
It is part, 10 ~ 30 parts of Chinese yam, 5 ~ 20 parts of 5 ~ 20 parts of, Shuo Di of west safflower, 5 ~ 20 parts of Waternut Herb, 3 ~ 15 parts of pine mushroom, 3 ~ 15 parts of certain herbaceous plants with big flowers of match, white
3 ~ 15 parts of art, 1 ~ 10 part of perilla leaf, 1 ~ 10 part of the root bark of shaggy-fruited dittany.
Preferably, the Chinese medicine composition of the treatment digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：15 ~ 25 parts of cassia twig, 15 ~ 25 parts of Chinese yam, 10 ~ 15 parts of 10 ~ 15 parts of, Shuo Di of west safflower, 10 ~ 15 parts of Waternut Herb, pine mushroom 6 ~ 12
Part, 6 ~ 12 parts of certain herbaceous plants with big flowers of match, 6 ~ 12 parts of the bighead atractylodes rhizome, 4 ~ 8 parts of perilla leaf, 4 ~ 8 parts of the root bark of shaggy-fruited dittany.
Preferably, the Chinese medicine composition of the treatment digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：20 parts of cassia twig, 20 parts of Chinese yam, 12 parts of 12 parts of, Shuo Di of west safflower, 12 parts of Waternut Herb, 9 parts of pine mushroom, match 9 parts of certain herbaceous plants with big flowers, 9 parts of the bighead atractylodes rhizome,
6 parts of perilla leaf, 6 parts of the root bark of shaggy-fruited dittany.
The preparation method of the Chinese medicine composition of above-mentioned treatment digestive system tumor Postsurgical Gastroparesis, comprises the following steps：
Step S1：Dry cassia twig, west safflower, Waternut Herb, match certain herbaceous plants with big flowers, the bighead atractylodes rhizome and perilla leaf are weighed respectively, are crushed, are mixed, add
To supercritical CO2In extraction kettle, the use of ethanol is that entrainer is extracted, obtains extract；
Step S2：Dry Chinese yam, Shuo Di, pine mushroom and the root bark of shaggy-fruited dittany are weighed, crushes, adds water, decocts, filters to obtain decoction liquor；
Step S3：The extract and decoction liquor are merged, concentrated, dries, ultramicro grinding, obtains Ultramicro-powder.
Preferably, in step S1, the process conditions of the extraction are：10 ~ 15MPa of extracting pressure, extraction temperature 30 ~ 40
DEG C, CO235 ~ 45L/h of fluid flow, 1.5 ~ 2.0h of extraction time.
Preferably, in step S1, the volume fraction of the ethanol is 95%.
Preferably, in step S2, the weight ratio of the water and the raw material after crushing is 8 ~ 10:1, decocting time is 45 ~ 60
Minute.
Preferably, in step S3, the concentration is when being concentrated under reduced pressure into 75 DEG C after merging the extract and decoction liquor
Relative density is 1.20 ~ 1.25.
Compared with prior art, beneficial effects of the present invention are as follows：
1）The present invention has dredging the channel, promoting blood circulation and removing blood stasis, invigorating the spleen to clear away damp pathogen concurrently using warming yang and benefiting qi, strengthening vital QI to eliminate pathogenic factors as main principle of reatment
The effect of, using cassia twig and Chinese yam as monarch drug in a prescription, using west safflower, capsule Di and Waternut Herb as ministerial drug, with pine mushroom, match certain herbaceous plants with big flowers, the bighead atractylodes rhizome, perilla leaf
It is all adjuvant with the root bark of shaggy-fruited dittany, compatibility is proper, cures mainly nausea caused by digestive system tumor Postsurgical Gastroparesis, vomits, early satiety, after the meal
It is glutted, the symptom such as abdominal distention, promote digestion health, strengthen body immunity.The medicine of each raw medicinal material of the present invention
Reason is as follows：
Cassia twig：For the dry twig of canella Chinese cassia tree.Spring, the harvesting of season in summer two, except defoliation, are dried, or section is dried.Nature and flavor
Acrid, sweet, warm.The thoughts of returning home, lung, bladder warp.Major function sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, flat gas that spins.《This warp is dredged
Card》Record：" all medicines must study carefully its body use, the sharp joint of cassia twig energy, warming meridians and promoting circulation of qi, this its body.”；
Chinese yam, it is the stem tuber of Dioscoreaceae plant Chinese yam.Nature and flavor are sweet, flat, nontoxic.Returns spleen, lung, kidney channel.Invigorating the spleen, tonifying lung, reinforce the kidney, benefit
Essence.Splenasthenic diarrhea is controlled, protracted dysentery, cough due to consumptive disease, is quenched one's thirst, under seminal emission, band, frequent urination；
West safflower, it is the drying column cap of Iridaceae crocus plant safron.Nature and flavor are sweet, put down, nontoxic.The thoughts of returning home, Liver Channel.Function
Cure mainly promoting blood circulation and removing blood stasis, removing pattogenic heat from the blood and toxic material from the body, resolving stagnation for tranquilization；
Shuo Di, it is caprifoliaceae plant Shuo Di herb or root, nature and flavor are sweet, acid, temperature, enter the liver channel of foot-Jueyin.Major function wind-dispelling removes
It is wet, promoting blood circulation to remove blood stasis；
Waternut Herb, it is the aerial stem of plant of sedge water chestnut.Bitter, it is cool in nature；Returns spleen, kidney channel；It is clearing heat and detoxicating, diuresis, drop inverse.It is main
Heat gonorrhea；Difficult urination；Oedema；Furunculosis；Hiccup；
Pine mushroom, it is the fructification of Tricholomataceae fungi Trichotoma matsutake.Nature and flavor are sweet, flat, nontoxic；Major function relaxing tendons and activating collaterals；Regulating qi-flowing for eliminating phlegm；
Dampness removing is not turbid.Main lumbocrural pain；It is numb in every limb；Grain does not relax；Abundant expectoration shortness of breath；Urine stranguria with turbid discharge；
Match certain herbaceous plants with big flowers：The herb of certain herbaceous plants with big flowers is matched for malvaceae plant.Nature and flavor micro-sweet；It is cool；It is nontoxic.Channel tropism lung；Liver；Large intestine channel.Major function is clear
Hot dampness removing；Removing toxicity for detumescence.《Guangxi Chinese herbal medicine》：" clearing heat and promoting diuresis, stasis eliminatings detumescence.Yellow River harnessing subcutaneous ulcer, dysentery, malaria, children's food stagnation, lung
Heat cough, laryngitis, boil, treating swelling and pain by traumatic injury.”；
The bighead atractylodes rhizome, it is the rhizome of the feverfew bighead atractylodes rhizome.Bitter；It is sweet；It is warm-natured.Returns spleen；Stomach.Strengthening the spleen and replenishing qi；Eliminate dampness and have diuretic effect；Hidroschesis；
It is antiabortive.Main deficiency-weakness of spleen-QI；Spiritlessness and weakness；The few abdominal distension of deficiency of food；Big loose stool is thin；Fluid retention stagnating in the interior；Difficult urination；Oedema；Phlegmatic vertigo；
Warm numbness is ached；Spontaneous perspiration due to deficiency of vital energy；
Perilla leaf, the leaf of wrinkled for labiate purple perilla, sharp purple perilla etc..Nature and flavor are pungent, temperature.Enter lung, the spleen channel.Deliver, cold dispelling, manage
Gas, and battalion.Cure cold chill, fever with aversion to cold, coughs, asthma, fullness and oppression of chest and abdomen, fetal irritability；
The root bark of shaggy-fruited dittany：For the dry root skin of rutaceae shaggy-fruited dittany.Bitter；It is salty；It is cold；It is nontoxic.Cure mainly heat-clearing and damp-drying drug；Dispelling wind and arresting itching；
Removing toxic substances.Rubella caused by main wind-heat wet poison；Eczema；Mange；Jaundice；Damp-heat arthralgia.
2）Many known disadvantages such as no thoroughness of the present invention based on existing western medical treatment, course for the treatment of length propose a kind of curative effect
Significantly, it is quick, there is the Chinese medicine composition that active treatment acts on to digestive system tumor Postsurgical Gastroparesis Syndrome, and provide
The preparation method of the Chinese medicine composition.The present invention is combined with whole body is dialectical using theory of traditional Chinese medical science for guidance, by Local Differentiation of Syndromes, is passed through
Medicine cooperates with, and realizes the dredging of internal mechanism of qi, adjustment negative and positive lifting, improves and eliminates stomach paralysis patient night sweat or spontaneous perspiration, weak, hair
The systemic manifestation such as the deficiency of both qi and yin such as heat, fire excess from yin deficiency, damp-heat blocking in the body and nausea, vomiting, early satiety, post-prandial fullness, belly are swollen
The grand local stagnation of the circulation of vital energy stasis blocking symptom of grade.Clinical practice proves, within stomach paralysis patient is used continuously one week Chinese medicine composition of the present invention
Normal diet can be recovered, cure rate can reach more than 95.0%, and effective percentage reaches 100%.
Embodiment
For a better understanding of the present invention, present disclosure, but this hair are further fairly set out with reference to embodiment
Bright protection content is not limited solely to the following examples.In the following description, give a large amount of concrete details so as to
More thorough understanding of the invention is provided.It will be apparent, however, to one skilled in the art that the present invention can be with
It is carried out without one or more of these details.
Embodiment 1：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：20 parts of cassia twig, 20 parts of Chinese yam, 12 parts of 12 parts of, Shuo Di of west safflower, 12 parts of Waternut Herb, 9 parts of pine mushroom, match 9 parts of certain herbaceous plants with big flowers, 9 parts of the bighead atractylodes rhizome,
6 parts of perilla leaf, 6 parts of the root bark of shaggy-fruited dittany.
The preparation method of the Chinese medicine composition of embodiment treatment digestive system tumor Postsurgical Gastroparesis, comprises the following steps：
Step S1：Dry cassia twig, west safflower, Waternut Herb, match certain herbaceous plants with big flowers, the bighead atractylodes rhizome and perilla leaf are weighed respectively, are crushed, are mixed, add
To supercritical CO2In extraction kettle, the use of ethanol is that entrainer is extracted, obtains extract；
Step S2：Dry Chinese yam, Shuo Di, pine mushroom and the root bark of shaggy-fruited dittany are weighed, is crushed, adds water, the water and the raw material after crushing
Weight ratio is 9:1, decoct 50 minutes, filter to obtain decoction liquor；
Step S3：The extract and decoction liquor are merged, concentrated, dries, ultramicro grinding, obtains Ultramicro-powder.
The process conditions of the extraction are：Extracting pressure 12MPa, 35 DEG C of extraction temperature, CO2Fluid flow 40L/h, extraction
Time 1.8h.
The volume fraction of the ethanol is 95%.
The concentration is that relative density is 1.23 when being concentrated under reduced pressure into 75 DEG C after merging the extract and decoction liquor.
Prepare gained Ultramicro-powder（Particle diameter≤75 μm）With single dose Vacuum Package, 10 grams every bag, as enema agent for oral administration
Use.
Taking bowel lavage application method orally is：Ultramicro-powder warm water is washed open, it is 39 ~ 41 DEG C to control temperature, uses removal syringe needle
Transfusion device carries out anus instillation, inserts anal tube depth about 15 ~ 20cm, and bowel lavage advises patient first to take left lateral position after terminating, then
Right lateral position, sat up after finally lying down about 30 minutes, so that medicine is spread as far as possible in enteron aisle, allow medicine as far as possible in enteron aisle
Retain medicine to discharge after more than 1 hour, to ensure decoction fully absorbing in enteron aisle.
The present invention shows that enema medicament is advantageous to without going past gastrointestinal anastomosis using bowel lavage administration for oral administration, clinical research
It heals, and can mitigate intestines and stomach load, avoids stimulation of the Chinese medicine to stomach lining, and can be to GI nerves system
Interior chemocepter and pharmacology receptor produce stimulation, promote intestines peristalsis, produce independence defecation, and exhaust reaction accelerates art
The recovery of rear intestinal function.
Embodiment 2：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：15 parts of cassia twig, 15 parts of Chinese yam, 10 parts of 10 parts of, Shuo Di of west safflower, 10 parts of Waternut Herb, 6 parts of pine mushroom, match certain herbaceous plants with big flowers 6,8 parts of the bighead atractylodes rhizome, purple
4 parts of perilla leaf, 4 parts of the root bark of shaggy-fruited dittany.
The preparation method of the Chinese medicine composition of embodiment treatment digestive system tumor Postsurgical Gastroparesis, comprises the following steps：
Step S1：Dry cassia twig, west safflower, Waternut Herb, match certain herbaceous plants with big flowers, the bighead atractylodes rhizome and perilla leaf are weighed respectively, are crushed, are mixed, add
To supercritical CO2In extraction kettle, the use of ethanol is that entrainer is extracted, obtains extract；
Step S2：Dry Chinese yam, Shuo Di, pine mushroom and the root bark of shaggy-fruited dittany are weighed, is crushed, adds water, the water and the raw material after crushing
Weight ratio is 8:1, decoct 45 minutes, filter to obtain decoction liquor；
Step S3：The extract and decoction liquor are merged, concentrated, dries, ultramicro grinding, obtains Ultramicro-powder.
The process conditions of the extraction are：Extracting pressure 10MPa, 30 DEG C of extraction temperature, CO2Fluid flow 35L/h, extraction
Time 1.5h.
Preferably, the volume fraction of the ethanol is 95%.
The concentration is that relative density is 1.21 when being concentrated under reduced pressure into 75 DEG C after merging the extract and decoction liquor.
Embodiment 3：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：25 parts of cassia twig, 25 parts of Chinese yam, 15 parts of 15 parts of, Shuo Di of west safflower, 15 parts of Waternut Herb, 12 parts of pine mushroom, 12 parts of certain herbaceous plants with big flowers of match, the bighead atractylodes rhizome 10
Part, 8 parts of perilla leaf, 8 parts of the root bark of shaggy-fruited dittany.
The preparation method of the Chinese medicine composition of embodiment treatment digestive system tumor Postsurgical Gastroparesis, comprises the following steps：
Step S1：Dry cassia twig, west safflower, Waternut Herb, match certain herbaceous plants with big flowers, the bighead atractylodes rhizome and perilla leaf are weighed respectively, are crushed, are mixed, add
To supercritical CO2In extraction kettle, the use of ethanol is that entrainer is extracted, obtains extract；
Step S2：Dry Chinese yam, Shuo Di, pine mushroom and the root bark of shaggy-fruited dittany are weighed, is crushed, adds water, the water and the raw material after crushing
Weight ratio is 10:1, decoct 60 minutes, filter to obtain decoction liquor；
Step S3：The extract and decoction liquor are merged, concentrated, dries, ultramicro grinding, obtains Ultramicro-powder.
The process conditions of the extraction are：Extracting pressure 15MPa, 40 DEG C of extraction temperature, CO2Fluid flow 45L/h, extraction
Time 2.0h.
The volume fraction of the ethanol is 95%.
The concentration is that relative density is 1.25 when being concentrated under reduced pressure into 75 DEG C after merging the extract and decoction liquor.
Embodiment 4：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：18 parts of cassia twig, 18 parts of Chinese yam, 12 parts of 12 parts of, Shuo Di of west safflower, 12 parts of Waternut Herb, 8 parts of pine mushroom, match 8 parts of certain herbaceous plants with big flowers, 6 parts of the bighead atractylodes rhizome,
5 parts of perilla leaf, 5 parts of the root bark of shaggy-fruited dittany.
The preparation method of the Chinese medicine composition of the present embodiment treatment digestive system tumor Postsurgical Gastroparesis refers to embodiment 1, no
Repeat again.
Embodiment 5：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：10 parts of cassia twig, 12 parts of Chinese yam, 5 parts of 5 parts of, Shuo Di of west safflower, 6 parts of Waternut Herb, 3 parts of pine mushroom, 3 parts of certain herbaceous plants with big flowers of match, 5 parts of the bighead atractylodes rhizome, purple perilla
1 part of leaf, 3 parts of the root bark of shaggy-fruited dittany.
The preparation method of the Chinese medicine composition of the present embodiment treatment digestive system tumor Postsurgical Gastroparesis refers to embodiment 1, no
Repeat again.
Embodiment 6：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：12 parts of cassia twig, 10 parts of Chinese yam, 8 parts of 8 parts of, Shuo Di of west safflower, 5 parts of Waternut Herb, 5 parts of pine mushroom, 5 parts of certain herbaceous plants with big flowers of match, 3 parts of the bighead atractylodes rhizome, purple perilla
3 parts of leaf, 1 part of the root bark of shaggy-fruited dittany.
The preparation method of the Chinese medicine composition of the present embodiment treatment digestive system tumor Postsurgical Gastroparesis refers to embodiment 1, no
Repeat again.
Embodiment 7：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：30 parts of cassia twig, 30 parts of Chinese yam, 18 parts of 20 parts of, Shuo Di of west safflower, 20 parts of Waternut Herb, 15 parts of pine mushroom, 15 parts of certain herbaceous plants with big flowers of match, the bighead atractylodes rhizome 14
Part, 10 parts of perilla leaf, 10 parts of the root bark of shaggy-fruited dittany.
The preparation method of the Chinese medicine composition of the present embodiment treatment digestive system tumor Postsurgical Gastroparesis refers to embodiment 1, no
Repeat again.
Embodiment 8：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：28 parts of cassia twig, 28 parts of Chinese yam, 20 parts of 18 parts of, Shuo Di of west safflower, 18 parts of Waternut Herb, 14 parts of pine mushroom, 14 parts of certain herbaceous plants with big flowers of match, the loose bighead atractylodes rhizome
15 parts, 9 parts of perilla leaf, 9 parts of the root bark of shaggy-fruited dittany.
Embodiment 9：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：20 parts of cassia twig, 20 parts of Chinese yam, 12 parts of 12 parts of, Shuo Di of west safflower, 12 parts of Waternut Herb, 9 parts of pine mushroom, match 9 parts of certain herbaceous plants with big flowers, 9 parts of the bighead atractylodes rhizome,
6 parts of perilla leaf, 6 parts of the root bark of shaggy-fruited dittany, 6 parts of loess, 6 parts of common evolvulus herb, 5 parts of bower actinidia root or leaf root, 5 parts of mouse hare dung, 5 parts of greyhair cipadessa root or leaf.
The Chinese medicine composition of present invention treatment digestive system tumor Postsurgical Gastroparesis increases loess on the basis of embodiment 1 ~ 8
3 ~ 10 parts by weight, the parts by weight of common evolvulus herb 3 ~ 10, the parts by weight of bower actinidia root or leaf root 1 ~ 7, the parts by weight of mouse hare dung 1 ~ 7, the weight of greyhair cipadessa root or leaf 1 ~ 7
Part.Wherein, loess：It is loose rich in calcium salt and calcareous concretion typically in lark, there are macroscopic macrovoid, prismatical joint
Development, more solid when drying, can be kept upright cliff, meet easy disintegrating after water infiltration, and depression occurs；It is sweet, warm-natured flat, nothing
Poison；Enter spleen, stomach two passes through；Major function and middle removing toxic substances；Control heatstroke vomiting and diarrhoea, dysentery, swollen ulcer drug, injury from falling down；《Book on Chinese herbal medicine is again
Newly》：" Appetizing spleen-tonifying, help digestion dampness removing, tonifying middle-Jiao and Qi." common evolvulus herb：Convolvulaceae common evolvulus herb platymiscium common evolvulus herb, with all herbal medicine；
Nature and flavor toil, it is cool；Enter liver,spleen,kidney three to pass through；Major function heat-clearing, dampness removing；Yellow River harnessing subcutaneous ulcer, dysentery, stranguria with turbid discharge, with, malignant boil swells, scabies.
Bower actinidia root or leaf root：For the root of Actinidiaceae plant tara vine；Nature and flavor are light；Micro-puckery；It is flat；Major function clearing heat and promoting diuresis；Wind-dispelling removes
Numbness；Removing toxicity for detumescence；Hemostasis；Main jaundice；Indigestion；Vomiting；Arthralgia pain due to rheumatism；Alimentary Tract Cancer；Large carbuncle boil；Traumatic injury；
Traumatism and bleeding；Agalactia.Mouse hare dung：For the excrement of pika Tibet pika；Whole year can adopt；The more heaps of excrement combine in hole
Mouthful；Receive after, well sifted soil, pick sandstone, dry；Bitter salty, temperature is nontoxic；《Traditional Chinese Medicine in Sichuan will》:" stimulate the menstrual flow, dissolving stasis.Control menstruation
Imbalance, postpartum abdominal pain, injury from falling down and hemostasis stagnate." greyhair cipadessa root or leaf, Meliaceae berry melia plant gray wool Cipadessa baecifera Miq, is used as medicine with leaf.
It is bitter in taste, it is cool.Major function is clearing heat and detoxicating, promoting the circulation of qi defaecation, preventing malaria.For catching a cold, heating is not moved back, malaria, constipation, abdomen
Bitterly, dysentery, rheumatic arthritis；Children's dermatitis, pruitus, burn and scald are controlled in external application.
Above-mentioned five kinds of Chinese medicine is made external application and sticks preparation, coordinates present invention enema agent for oral administration to make in the method for point-application
With.External application of the present invention sticks the specific preparation method of preparation：Common evolvulus herb, bower actinidia root or leaf root, mouse hare dung and greyhair cipadessa root or leaf are weighed respectively,
Add water to cook 2 times, decoct 60 minutes every time, filtering, merge each secondary filtrate, concentrate filtrate to paste, dry, pulverize,
Fine powder is obtained, gained fine powder is well mixed with loess, adds peppermint oil mediation, obtained external application sticks preparation.External application acupuncture point one
As select Shenque, Shangwan, the middle part of gastric cavity, pylorus.
Oral medicinal herb is combined by the present invention with outer control, and whole body is mutually unified with Local Differentiation of Syndromes, rushes down its " too " with mending it " no
And " therapy mutually supplement；By the overall process of herbal retention enema and external application of Chinese medicine partner treatment, a kind of action is provided for patient
Faster, better efficacy, safe Chinese medicine composition.
Embodiment 10：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material of following parts by weight
It is made：20 parts of cassia twig, 20 parts of Chinese yam, 12 parts of 12 parts of, Shuo Di of west safflower, 12 parts of Waternut Herb, 9 parts of pine mushroom, 9 parts of certain herbaceous plants with big flowers of match, the bighead atractylodes rhizome 9
Part, 6 parts of perilla leaf, 6 parts of the root bark of shaggy-fruited dittany, 3 parts of loess, 3 parts of common evolvulus herb, 1 part of bower actinidia root or leaf root, 1 part of mouse hare dung, 1 part of greyhair cipadessa root or leaf.
Embodiment 11：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material of following parts by weight
It is made：20 parts of cassia twig, 20 parts of Chinese yam, 12 parts of 12 parts of, Shuo Di of west safflower, 12 parts of Waternut Herb, 9 parts of pine mushroom, 9 parts of certain herbaceous plants with big flowers of match, the bighead atractylodes rhizome 9
Part, 6 parts of perilla leaf, 6 parts of the root bark of shaggy-fruited dittany, 10 parts of loess, 10 parts of common evolvulus herb, 7 parts of bower actinidia root or leaf root, 7 parts of mouse hare dung, 7 parts of greyhair cipadessa root or leaf.
Comparative example 1：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：20 parts of cassia twig, 20 parts of Chinese yam, 9 parts of pine mushroom, 9 parts of certain herbaceous plants with big flowers of match, 9 parts of the bighead atractylodes rhizome, 6 parts of perilla leaf, 6 parts of the root bark of shaggy-fruited dittany.
The comparative example omits the use of west safflower, Shuo Di and Waternut Herb, and preparation method refers to embodiment 1.
Comparative example 2：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：5 parts of cassia twig, 5 parts of Chinese yam, 12 parts of 12 parts of, Shuo Di of west safflower, 12 parts of Waternut Herb, 6 parts of perilla leaf, 6 parts of the root bark of shaggy-fruited dittany.
The comparative example omits the use of pine mushroom, match certain herbaceous plants with big flowers and the bighead atractylodes rhizome, and preparation method refers to embodiment 1.
Comparative example 3：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：5 parts of cassia twig, 5 parts of Chinese yam, 12 parts of 12 parts of, Shuo Di of west safflower, 12 parts of Waternut Herb, 6 parts of perilla leaf, 6 parts of the root bark of shaggy-fruited dittany.
The comparative example omits the use of perilla leaf and the root bark of shaggy-fruited dittany, and preparation method refers to embodiment 1.
Comparative example 4：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, by the raw material system of following parts by weight
Into：5 parts of cassia twig, 5 parts of Chinese yam, 12 parts of 12 parts of, Shuo Di of west safflower, 12 parts of Waternut Herb, 9 parts of pine mushroom, 9 parts of certain herbaceous plants with big flowers of match, 9 parts of the bighead atractylodes rhizome, purple
6 parts of perilla leaf, 6 parts of the root bark of shaggy-fruited dittany.
The comparative example reduces the usage amount of cassia twig and Chinese yam, and preparation method refers to embodiment 1.
Comparative example 5：A kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, it is formulated same as Example 1, institute
Unlike：The preparation method of the Chinese medicine composition is：
Weigh dry cassia twig, Chinese yam, west safflower, Shuo Di, Waternut Herb, pine mushroom, match certain herbaceous plants with big flowers, the bighead atractylodes rhizome, perilla leaf and the root bark of shaggy-fruited dittany, powder
It is broken, add water, the water is 9 with the weight ratio of raw material after crushing:1, decoct 50 minutes, decoction liquor is filtered to obtain, by the decoction
Liquid is concentrated into the lotion that 75 DEG C of relative densities are 1.23；The lotion is dried, ultramicro grinding, obtains Ultramicro-powder.
Incompatibility is not present in 1 ~ comparative example of comparative example 5, meets the basic principle of Chinese prescription.
Observation of curative effect and evaluation
1.1 general information：Choose 240 digestive system tumor Postsurgical Gastroparesis patients' accepting for medical treatment in June, 2013 in June, 2017
Clinical data.All patients are randomly divided into 8 groups, are respectively：1 group is observed, 2 groups is observed, contrasts 1 group, contrasts 2 groups, contrast 3
Group, 4 groups of contrast, contrast 5 groups and control group, every group of 30 patients.Through statistics, every group of patient in age, sex composition ratio, disease
No difference of science of statistics (P ＞ 0.05) in the general information index such as journey, it is balanced comparable.Patient is through gastroscope or gastrointestinal image inspection
Gastric emptying obstacle is turned out to be, excludes mechanical obstruction, is mainly shown as night sweat or the systemic disease such as spontaneous perspiration, weak, heating
The local symptoms such as shape and nausea, vomiting, early satiety, post-prandial fullness, abdominal distention.All patients give general treatment：Fasting water,
Gastrointestinal decompression, maintain water-electrolyte balance, enough nutritional supports etc..
1.2 diagnostic criteria：1. thorax and abdomen malignant history of operation；2. stomach drainage flow is more than 800mL/d；3. occur abdominal distension, stomachache,
The symptoms such as Nausea and vomiting；4. by 1 or multiple inspection prompting without mechanical obstruction；5. lost without obvious Water-Electrolyte or soda acid
Weighing apparatus；6. without the underlying disease for causing stomach paralysis, such as diabetes, chorionitis, hypothyroidism；7. application does not influence flat
The medicine that sliding flesh shrinks.
1.3 treatment method：Control group patient gives oral 3 times/d of Mosapride 5mg (Chinese medicines quasi-word H19990317), raw
Reason salt solution 100mL+ metoclopramides (Chinese medicines quasi-word H32021539) 10mg intravenous drips, 2 times/d.Observe 1 group of patient and give embodiment
1 oral medicinal herb preparation, 10g/ times, enema treatment, 2 times a day.Observe 2 groups of patients and give the oral medicinal herb preparation of embodiment 9+Chinese medicine
Externally applied formulation, wherein, oral medicinal herb preparation 10g/ times, enema treatment, 2 times a day；Traditional Chinese medicine external preparation, point-application 2 times/
My god.Contrast 1 group of patient and give the oral medicinal herb preparation of comparative example 1,10g/ times, enema treatment, 2 times a day.Contrast 2 groups of patients to
Give the oral medicinal herb preparation of comparative example 2,10g/ times, enema treatment, 2 times a day.Contrast 3 groups of patients and give the oral medicinal herb of comparative example 3
Preparation, 10g/ times, enema treatment, 2 times a day.4 groups of patients of comparative example give the oral medicinal herb preparation of comparative example 4,10g/ times, bowel lavage
Treatment, 2 times a day.5 groups of patients of comparative example give the oral medicinal herb preparation of comparative example 5,10g/ times, enema treatment, 2 times a day.
1.4 curative effect determinate standard：Unified tumor post-operation Gastroparesis syndrome curative effect determinate standard is there is no at present, according to for many years
Clinical experience is drafted as follows.Cure：After treatment primary symptom disappear, stomach tube drainage flow≤100mL/24h, folder close stomach tube observation 24h without
It is uncomfortable then pull out stomach tube, recover feed without significant discomfort.Take a turn for the better：Primary symptom takes a turn for the better after treatment, stomach tube drainage flow>100mL/24h, stomach
Pipe clamp feels abdominal distension again after closing.It is invalid：Primary symptom is without improvement after treatment.Stomach tube drainage flow does not significantly reduce, and still needs to gastrointestinal decompression.
1.5 observation index：Patient's gastroenteritic power recovery time is observed, with gurgling sound recovery and passage of gas by anus, extracts stomach tube
It can feed and be defined.Observing time is 4 weeks.Local skin whether there is allergic reaction and its degree after observation external application for curing.
1.6 statistical procedures：All datas carry out statistical analysis using SPSS17.0 statistics softwares bag, count
Data is expressed as a percentage, χ2Inspection is analyzed；P ＜ 0.05 are that difference is statistically significant.
1.7 therapeutic effect
1.7.1 eight groups of patient clinical Comparison of therapeutic
It is as shown in table 1 below, cure rate：The cure rate for observing 1 group is 96.7%, and the cure rate of 2 groups of observation is 100%, 1 group of contrast ~
5 groups of cure rate is contrasted below 70%, the cure rate of control group is only 40.0%.Total effective rate：Observe 1 group and 2 groups of observation
Improvement rate reach 100%, and contrast the improvement rate of 5 groups of 1 group ~ contrast below 75%, the improvement rate of control group reaches
86.7%.The above results show that Chinese medicine composition of the present invention has excellent therapeutic effect to digestive system tumor Postsurgical Gastroparesis,
Mutual coordinated realizes the performance of above-mentioned curative effect between each raw material.Concrete condition see the table below 1.
1 eight groups of patient clinical Comparison of therapeutic of table [example/%]
,
Note：Cure rate（%）=cure case/total case number of cases * 100%；Improvement rate（%）=improvement case/total case number of cases * 100%；Always have
Efficiency（%）=cure rate+improvement rate.
1.7.2 eight groups of diet recover the comparison of normal time
As shown in table 2 below, the diet of 2 groups of patients of 1 group of observation and observation recovers normal time within 1 week, and observes 2 groups
Compared with 1 group better of observation.The diet recovery normal time for contrasting 1 group ~ contrast, 5 groups of patients is equal compared with 2 groups of 1 group of observation and observation
Dramatically increase.The diet recovery normal time of control group patient is most long, although in curative effect statistically, its efficient relatively contrast 1
Group and contrast are 2 groups higher, but diet recovery normal time is but significantly slower compared with 2 groups of 1 group of contrast and contrast.The above results table
Bright, Chinese medicine composition of the present invention can effectively treat digestive system tumor Postsurgical Gastroparesis, can make patient's in shorter time
Diet recovers normal, takes effect faster.Concrete condition see the table below 2.
2 eight groups of diet of table recover normal time comparison [, d]
,
2 groups are observed during treatment, patient's local skin is without allergic reaction.
It is non-that above-mentioned evaluation result absolutely proves that Chinese medicine composition of the present invention has to treatment digestive system tumor Postsurgical Gastroparesis
The effect of Chang Xianzhu.Mosapride used in control group and metoclopramide are the normal of clinical treatment digestive system tumor Postsurgical Gastroparesis
Western medicine is advised, although can improve and eliminate stomach paralysis symptom, its onset time is slow, and usage amount should not be excessive, potential side effect
It is not easy to discover.The present invention is taken orally using Chinese medicine composition bowel lavage, not only evident in efficacy, and short treating period, can be made in shorter time
Patient recovers normal diet, and can adjust human body gas on the whole, resistivity of the enhancing human body to disease.
Finally illustrate, the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, this area is common
Other modifications or equivalent substitution that technical staff is made to technical scheme, without departing from technical solution of the present invention
Spirit and scope, all should cover among scope of the presently claimed invention.
Claims (8)
1. a kind of Chinese medicine composition for treating digestive system tumor Postsurgical Gastroparesis, it is characterised in that by the raw material of following parts by weight
It is made：10 ~ 30 parts of cassia twig, 10 ~ 30 parts of Chinese yam, 5 ~ 20 parts of 5 ~ 20 parts of, Shuo Di of west safflower, 5 ~ 20 parts of Waternut Herb, 3 ~ 15 parts of pine mushroom,
Match 3 ~ 15 parts of certain herbaceous plants with big flowers, 3 ~ 15 parts of the bighead atractylodes rhizome, 1 ~ 10 part of perilla leaf, 1 ~ 10 part of the root bark of shaggy-fruited dittany.
2. the Chinese medicine composition for the treatment of digestive system tumor Postsurgical Gastroparesis according to claim 1, it is characterised in that：Cassia twig
15 ~ 25 parts, 15 ~ 25 parts of Chinese yam, 10 ~ 15 parts of 10 ~ 15 parts of, Shuo Di of west safflower, 10 ~ 15 parts of Waternut Herb, 6 ~ 12 parts of pine mushroom, match certain herbaceous plants with big flowers 6 ~
12 parts, 6 ~ 12 parts of the bighead atractylodes rhizome, 4 ~ 8 parts of perilla leaf, 4 ~ 8 parts of the root bark of shaggy-fruited dittany.
3. the Chinese medicine composition for the treatment of digestive system tumor Postsurgical Gastroparesis according to claim 1, it is characterised in that：Cassia twig
20 parts, 20 parts of Chinese yam, 12 parts of 12 parts of, Shuo Di of west safflower, 12 parts of Waternut Herb, 9 parts of pine mushroom, match 9 parts of certain herbaceous plants with big flowers, 9 parts of the bighead atractylodes rhizome, perilla leaf 6
Part, 6 parts of the root bark of shaggy-fruited dittany.
4. the preparation side of the Chinese medicine composition of the treatment digestive system tumor Postsurgical Gastroparesis according to any one of claim 1 ~ 3
Method, it is characterised in that comprise the following steps：
Step S1：Dry cassia twig, west safflower, Waternut Herb, match certain herbaceous plants with big flowers, the bighead atractylodes rhizome and perilla leaf are weighed respectively, are crushed, are mixed, add
To supercritical CO2In extraction kettle, the use of ethanol is that entrainer is extracted, obtains extract；
Step S2：Dry Chinese yam, Shuo Di, pine mushroom and the root bark of shaggy-fruited dittany are weighed, crushes, adds water, decocts, filters to obtain decoction liquor；
Step S3：The extract and decoction liquor are merged, concentrated, dries, ultramicro grinding, obtains Ultramicro-powder.
5. the preparation method of the Chinese medicine composition for the treatment of digestive system tumor Postsurgical Gastroparesis according to claim 4, it is special
Sign is：In step S1, the process conditions of the extraction are：10 ~ 15MPa of extracting pressure, 30 ~ 40 DEG C of extraction temperature, CO2Fluid
35 ~ 45L/h of flow, 1.5 ~ 2.0h of extraction time.
6. the preparation method of the Chinese medicine composition for the treatment of digestive system tumor Postsurgical Gastroparesis according to claim 4, it is special
Sign is：In step S1, the volume fraction of the ethanol is 95%.
7. the preparation method of the Chinese medicine composition for the treatment of digestive system tumor Postsurgical Gastroparesis according to claim 4, it is special
Sign is：In step S2, the weight ratio of the water and the raw material after crushing is 8 ~ 10:1, decocting time is 45 ~ 60 minutes.
8. the preparation method of the Chinese medicine composition for the treatment of digestive system tumor Postsurgical Gastroparesis according to claim 4, it is special
Sign is：In step S3, the concentration is relative density when being concentrated under reduced pressure into 75 DEG C after merging the extract and decoction liquor
For 1.20 ~ 1.25.
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| CN105169355A (en) * | 2015-10-27 | 2015-12-23 | 北京中医药大学东方医院 | Traditional Chinese medicine composition for treating digestive system tumor postsurgical gastroparesis and preparation method thereof |
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| CN105169355A (en) * | 2015-10-27 | 2015-12-23 | 北京中医药大学东方医院 | Traditional Chinese medicine composition for treating digestive system tumor postsurgical gastroparesis and preparation method thereof |
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| CN116173124A (en) * | 2022-12-14 | 2023-05-30 | 宏铖同创(山东)医药科技有限公司 | Traditional Chinese medicine composition for treating digestive system tumor postoperative gastroparesis and preparation system |
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