CN104043037A - Medicinal preparation used for treating acute exacerbation of chronic obstructive pulmonary disease - Google Patents

Abstract

The invention provides a medicinal preparation used for treating acute exacerbation of chronic obstructive pulmonary disease. Raw medicines used in the invention comprise Salvia miltiorrhiza, Agrimonia eupatoria, Polygonatum sibiricum, Rhizoma Curcumae, cassia twig, Fritillaria thunbergii Miq., White Mulberry Root-bark, Semen Euryales, Morinda parvifolia, Spina Gleditsiae, Geranium wilfordii Maxim., Aletris pauciflora var. khasiana, Silene conoidea L., Conyza japonica, Radix Asparagi, Herba Leucatis Molloissimae, Loquat leaf, Rhizoma Anemarrhenae, Radix Glehniae, Herbal Ephedrae, Snakegourd Fruit, Radix Morindae officinalis, Boswellia carteri, Yetbadetajo Hert, Hippophae rhamnoides, Rhizoma Polygoni Cuspidati, Changium smyrnioides, Bamboo Shavings, Acorus gramineus and cortex lycii. The medicinal preparation has the advantages of good treatment effect, improvement of the curing rate of patients, and few untoward effects, and deserves popularization and application.

Description

Be used for the treatment of the pharmaceutical preparation of acute exacerbation of chronic obstructive pulmonary disease

Technical field

The present invention relates to Chinese medicine technical field, relate in particular to a kind of pharmaceutical preparation that is used for the treatment of acute exacerbation of chronic obstructive pulmonary disease.

Background technology

Chronic obstructive pulmonary disease (chronic obstructive pulmonary disease, COPD) be a kind of respiratory system common disease that can prevent and treat, it is characterized in that the flow limitation of sustainable existence, and be and carry out sexual development, due to number of patients increasing year by year, mortality rate is high, social economical burden increases the weight of, therefore effective control of COPD has been become to an important public health problem, it is the sixth-largest fatal disease in the world at present, World Health Organization (WHO) (WHO) expects the year two thousand twenty, it will become the disease of the fifth-largest burden in world wide.

Generally believe that at present COPD is taking air flue, pulmonary parenchyma and pulmonary vascular chronic inflammatory disease as main, it is progressive increase the weight of normal relevant to respiratory tract infection; Many Reusabilities of patient antibiotic, Multiple Classes of Antibiotics is produced to drug resistance, and clinical symptoms is wayward, curative effect limitation, therefore simple doctor trained in Western medicine long-term treatment COPD effect weakens with the lengthening of the course of disease, does not have at present a kind of Western medicine medicine can stop COPD Pulmonary Function to decline for a long time.The frequent outbreak of Acute Exacerbation Period, can accelerate the deterioration of its pulmonary function, has a strong impact on quality of life, shortens COPD patient's the existence time limit.

Therefore, find medicine effectively and, to alleviate the disease of COPD Acute Exacerbation Period, improve pulmonary function, alleviating Airway Remodeling is current medical circle problem in the urgent need to address.

In addition, although doctor trained in Western medicine has definite curative effect to COPD, its prolonged and repeated use broad ectrum antibiotic, theophylline class medicine and bronchodilator can cause gastric mucosal barrier impaired, alteration of intestinal flora, displacement, cause the side effect such as digestive and absorptive functions obstacle, and it is short to hold time.Therefore after patient treatment, life quality is poor.

Although Chinese medicine does not have this name of disease of chronic obstructive pulmonary disease, according to its typical clinical manifestation, the traditional Chinese medical science is belonged to the categories such as " cough ", " the syndrome of dyspnea ", " bronchial wheezing ", " phlegm retention " ", pulmonary distension ".Its cause of disease complexity, has diseases caused by exogenous pathogenic factor, the large class of internal injury two in general, and diseases caused by exogenous pathogenic factor are six climate exopathogens exopathogen invasion and attack lung system; Internal injury be improper diet, disorder of emotion, labor want prolonged illness etc. cause abnormal rising of lung-QI, a surname fall mistake department or gas without lead, kidney mistake is taken the photograph to receive and is formed.Pathological changes, first at lung, continues and affects spleen, liver, kidney, and the later stage is sick and in the heart; Because lung governing qi, department breathe, outside master meter is defended, the many attackings the lung first of exopathogen, cause lung qi a surname to fall unfavorable, and superinverse is for coughing, and abnormal ascending-descending of QI is breathed heavily, and the deficiency of the lung for a long time, defends outer dereliction of duty, and the heresy of six climate exopathogens is attacked lung repeatedly, brings out the generation of primary disease; If pneumonopathy and spleen, child-organ disease involving its motherorgan, dysfunction of the spleen in transportation, deficiency of both lung and spleen, deficiency of vital energy abundant expectoration; The lung being the dominator of QI, the kidney being the root of QI, if the dificiency of the lung due to protracted disease and kidney, gold is unboiled water not, causes kidney qi feeble and exhausted, the not main gas of lung, failure of the kidney in receiving QI, asthma increases the weight of day by day, short breath and difficulty to continue breathing, air-breathing particularly difficulty, moving more so.

This pathological changes, first at lung, continues and affects spleen, kidney, and the later stage is sick and in the heart.The spleen being the foundation of acquired constitution, " taste one are hindered, and all kinds of diseases and ailments are raw ", " splenogastric asthenia; receiving is all difficult, vigour is a little less than this, hundred heresies are easily invaded ", " the lung being the utensil for storing phlegm; the spleen being the source of producing phlegm ", " lung qi wound and also unclear ... spleen wet moving and be expectorant also ", visible spleen and lung are in close relations, Li Dongyuan has proposed the opinion of " taste one void, lung qi first absolutely ".In traditional Chinese medical science five elements' theory, spleen pertaining to the earth, the lung belonging to metal, earth generating metal in generation-inhibition in five elements, therefore the mother that spleen is lung, both can interact.

Many because exopathogen is attacked lung for COPD patients during acute stage chronic obstructive pulmonary disease acute exacerbation, impairment of dispersing and descending function of the lung, wind-phlegm volt lung, with the passing of time the deficiency of the lung, expectorant is turbid to be kept, and every sense exopathogen brings out and makes state of an illness outbreak aggravation, therefore chronic obstructive pulmonary disease Acute Exacerbation Period multilist is now coughed, is coughed up phlegm, amount of expectoration increases, and is glutinous purulence.Because its amount of expectoration increases, be purulence or the glutinous purulence inflammation characteristicness such as heat that can occur together, in the how relatively domination of pathogen of the traditional Chinese medical science, and the author is clinical common with syndrome of phlegm-heat obstructing lung.Phlegm-heat obstructing in the lung person mostly is in phlegm-damp and accumulates, and feels again exopathogen, wind-heat invading the lung, enter inner heat-transformation, the raw expectorant of consumption liquid, due to the mechanism of qi that is jammed, and the turbid interior life of expectorant, in stasis body, QI-blood circulation is not smooth, expectorant, heat, stasis of blood combined pathogens obstructing airway, inaccessible lung qi can cause impairment of purifying and descending function of the lung, treatment is taking removing heat-phlegm, respectful lung sending down the abnormal ascending QI as main, and assistant is with blood circulation promoting and blood stasis dispelling, eliminating evil in order to eutopic reduction.

According to Chinese traditional treatment theory, the present invention is taking lung heat clearing away, sputum eliminating, benefiting QI for activating blood circulation, strengthening spleen, tonifying kidney as Therapeutic Principle, the invention provides a kind of pharmaceutical preparation that is used for the treatment of acute exacerbation of chronic obstructive pulmonary disease, its therapeutic effect is good, can improve patient's cure rate, untoward reaction is few, is worthy of popularization.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of pharmaceutical preparation that is used for the treatment of acute exacerbation of chronic obstructive pulmonary disease, and its therapeutic effect is good, can improve patient's cure rate, and untoward reaction is few, is worthy of popularization.

For solving the problems of the technologies described above, the invention provides a kind of pharmaceutical preparation that is used for the treatment of acute exacerbation of chronic obstructive pulmonary disease, its crude drug comprises Radix Salviae Miltiorrhizae, Herba Agrimoniae, Rhizoma Polygonati, Rhizoma Curcumae, Ramulus Cinnamomi, Bulbus Fritillariae Thunbergii, Cortex Mori, Semen Euryales, Herba Morindae Parvifoliae, Spina Gleditsiae, Herba Erodii, Herba Aletridis Khasianae, Herba Silenes conoideae, Chinese liquor grass, Radix Asparagi, Leucas mollissima Wall., Folium Eriobotryae, the Rhizoma Anemarrhenae, Radix Glehniae, Herba Ephedrae, Fructus Trichosanthis, Radix Morindae Officinalis, Olibanum, Herba Ecliptae, Fructus Hippophae, Rhizoma Polygoni Cuspidati, Radix Changii, Caulis Bambusae In Taenia, Rhizoma Acori Graminei and Cortex Lycii.

Wherein, in described pharmaceutical preparation, the weight of each crude drug is respectively: Radix Salviae Miltiorrhizae 35g～45g, Herba Agrimoniae 10g～20g, Rhizoma Polygonati 30g～40g, Rhizoma Curcumae 25g～35g, Ramulus Cinnamomi 15g～25g, Bulbus Fritillariae Thunbergii 20g～30g, Cortex Mori 15g～25g, Semen Euryales 20g～30g, Herba Morindae Parvifoliae 15g～25g, Spina Gleditsiae 10g～20g, Herba Erodii 15g～25g, Herba Aletridis Khasianae 25g～35g, Herba Silenes conoideae 20g～30g, Chinese liquor grass 20g～30g, Radix Asparagi 35g～45g, Leucas mollissima Wall. 15g～25g, Folium Eriobotryae 15g～25g, Rhizoma Anemarrhenae 25g～35g, Radix Glehniae 30g～40g, Herba Ephedrae 15g～25g, Fructus Trichosanthis 10g～20g, Radix Morindae Officinalis 15g～25g, Olibanum 10g～20g, Herba Ecliptae 25g～35g, Fructus Hippophae 15g～25g, Rhizoma Polygoni Cuspidati 30g～40g, Radix Changii 25g～35g, Caulis Bambusae In Taenia 20g～30g, Rhizoma Acori Graminei 30g～40g and Cortex Lycii 25g～35g.

Wherein, in described pharmaceutical preparation, the weight of each crude drug is respectively: Radix Salviae Miltiorrhizae 35g～40g, Herba Agrimoniae 10g～15g, Rhizoma Polygonati 30g～35g, Rhizoma Curcumae 25g～30g, Ramulus Cinnamomi 15g～20g, Bulbus Fritillariae Thunbergii 20g～25g, Cortex Mori 15g～20g, Semen Euryales 20g～25g, Herba Morindae Parvifoliae 15g～20g, Spina Gleditsiae 10g～15g, Herba Erodii 15g～20g, Herba Aletridis Khasianae 30g～35g, Herba Silenes conoideae 25g～30g, Chinese liquor grass 25g～30g, Radix Asparagi 40g～45g, Leucas mollissima Wall. 20g～25g, Folium Eriobotryae 20g～25g, Rhizoma Anemarrhenae 30g～35g, Radix Glehniae 35g～40g, Herba Ephedrae 20g～25g, Fructus Trichosanthis 15g～20g, Radix Morindae Officinalis 20g～25g, Olibanum 15g～20g, Herba Ecliptae 30g～35g, Fructus Hippophae 20g～25g, Rhizoma Polygoni Cuspidati 35g～40g, Radix Changii 30g～35g, Caulis Bambusae In Taenia 25g～30g, Rhizoma Acori Graminei 35g～40g and Cortex Lycii 30g～35g.

Wherein, in described pharmaceutical preparation, the weight of each crude drug is respectively: Radix Salviae Miltiorrhizae 40g, Herba Agrimoniae 15g, Rhizoma Polygonati 35g, Rhizoma Curcumae 30g, Ramulus Cinnamomi 20g, Bulbus Fritillariae Thunbergii 25g, Cortex Mori 20g, Semen Euryales 25g, Herba Morindae Parvifoliae 20g, Spina Gleditsiae 15g, Herba Erodii 20g, Herba Aletridis Khasianae 30g, Herba Silenes conoideae 25g, Chinese liquor grass 25g, Radix Asparagi 40g, Leucas mollissima Wall. 20g, Folium Eriobotryae 20g, Rhizoma Anemarrhenae 30g, Radix Glehniae 35g, Herba Ephedrae 20g, Fructus Trichosanthis 15g, Radix Morindae Officinalis 20g, Olibanum 15g, Herba Ecliptae 30g, Fructus Hippophae 20g, Rhizoma Polygoni Cuspidati 30g, Radix Changii 25g, Caulis Bambusae In Taenia 20g, Rhizoma Acori Graminei 30g and Cortex Lycii 25g.

Wherein, described pharmaceutical preparation can be prepared into granule and capsule.

The present invention also provides the preparation method of said medicine preparation, in the time that prepared pharmaceutical preparation is granule, is specially:

The first step, gets Rhizoma Polygonati, Semen Euryales, Herba Aletridis Khasianae, Radix Asparagi, Radix Glehniae and Herba Ecliptae, pulverizes respectively, mix by above-mentioned weight, it is that in 85%～95% ethanol, the addition of the ethanol that every 100g mixture is corresponding is 300g that the mixture after mix homogeneously is dissolved in to determining alcohol, flood 24 hours～36 hours, adopt subsequently the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and is dried, and obtains the first powder;

Second step, Ramulus Cinnamomi, Bulbus Fritillariae Thunbergii, Herba Morindae Parvifoliae, Chinese liquor grass, the Rhizoma Anemarrhenae, Fructus Trichosanthis, Rhizoma Polygoni Cuspidati, Radix Changii, Caulis Bambusae In Taenia, Rhizoma Acori Graminei and Cortex Lycii are pulverized respectively, mixed by above-mentioned weight, it is the Chinese liquor of 50 DEG C～60 DEG C that the mixture after the mix homogeneously that every 100g obtains is put into 400ml alcoholic strength, sealing is soaked 15～20 days, subsequent boiling 1 hour～3 hours, leaves standstill 12 hours, filters, the filtrate obtaining is concentrated into removes all Chinese liquor, pulverize and be dried, obtain the second powder, filtering residue is for subsequent use;

The 3rd step, pulverizes remaining component respectively, mixes by above-mentioned weight, obtain mixture, this mixture of every 300g, adds 1L～2L water, heating decocts 3 hours～5 hours, and decoction liquor is filtered, and filtering residue mixes with the filtering residue that second step obtains, the filtering residue that every 300g mixes adds 1L～2L water, heating decocts 2 hours～4 hours, and decoction liquor is filtered, and the filtrate after filtering is concentrated into and removes all water, pulverize sick being dried, obtain the 3rd powder;

The 4th step; the first powder, the second powder, the 3rd powder are mixed; the powder of mixing is added to mass percent 20%～30% cane sugar powder with respect to mixed-powder quality; taking determining alcohol as 75%～85% ethanol soft material processed, granulate with oscillating granulator, at 60 DEG C, dry; granulate; obtain medicinal granule, splitting splendid attire, every bag of 10g.

The present invention also provides the preparation method of said medicine preparation, in the time that prepared pharmaceutical preparation is granule, is specially:

The first step, gets Rhizoma Polygonati, Semen Euryales, Herba Aletridis Khasianae, Radix Asparagi, Radix Glehniae and Herba Ecliptae, pulverizes respectively, mix by above-mentioned weight, it is that in 85%～95% ethanol, the addition of the ethanol that every 100g mixture is corresponding is 300g that the mixture after mix homogeneously is dissolved in to determining alcohol, flood 24 hours～36 hours, adopt subsequently the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and is dried, and obtains the first powder;

Second step, Ramulus Cinnamomi, Bulbus Fritillariae Thunbergii, Herba Morindae Parvifoliae, Chinese liquor grass, the Rhizoma Anemarrhenae, Fructus Trichosanthis, Rhizoma Polygoni Cuspidati, Radix Changii, Caulis Bambusae In Taenia, Rhizoma Acori Graminei and Cortex Lycii are pulverized respectively, mixed by above-mentioned weight, it is the Chinese liquor of 50 DEG C～60 DEG C that the mixture after the mix homogeneously that every 100g obtains is put into 400ml alcoholic strength, sealing is soaked 15～20 days, subsequent boiling 1 hour～3 hours, leaves standstill 12 hours, filters, the filtrate obtaining is concentrated into removes all Chinese liquor, pulverize and be dried, obtain the second powder, filtering residue is for subsequent use;

The 3rd step, pulverizes remaining component respectively, mixes by above-mentioned weight, obtain mixture, this mixture of every 300g, adds 1L～2L water, heating decocts 3 hours～5 hours, and decoction liquor is filtered, and filtering residue mixes with the filtering residue that second step obtains, the filtering residue that every 300g mixes adds 1L～2L water, heating decocts 2 hours～4 hours, and decoction liquor is filtered, and the filtrate after filtering is concentrated into and removes all water, pulverize sick being dried, obtain the 3rd powder;

The 4th step, the first powder, the second powder, the 3rd powder are mixed, the mixture obtaining is mixed homogeneously with starch, the amount of starch that every 100g mix products adds is 100g, add determining alcohol and be 25% alcohol granulation, the quality of the ethanol adding is equivalent to 0.1～0.2 times of mixture quality of mix products and starch, by particle drying, add magnesium stearate, the weight of magnesium stearate is equivalent to 0.01～0.02 times of mixture quality of mix products and starch, mix homogeneously, packs into in capsule, obtains capsule.

Beneficial effect of the present invention:

The pharmaceutical preparation therapeutic effect that is used for the treatment of chronic obstructive pulmonary disease provided by the invention is good, can improve patient's cure rate, and untoward reaction is few, is worthy of popularization.

Detailed description of the invention

The invention provides a kind of pharmaceutical preparation that is used for the treatment of chronic obstructive pulmonary disease, its crude drug comprises Radix Salviae Miltiorrhizae, Herba Agrimoniae, Rhizoma Polygonati, Rhizoma Curcumae, Ramulus Cinnamomi, Bulbus Fritillariae Thunbergii, Cortex Mori, Semen Euryales, Herba Morindae Parvifoliae, Spina Gleditsiae, Herba Erodii, Herba Aletridis Khasianae, Herba Silenes conoideae, Chinese liquor grass, Radix Asparagi, Leucas mollissima Wall., Folium Eriobotryae, the Rhizoma Anemarrhenae, Radix Glehniae, Herba Ephedrae, Fructus Trichosanthis, Radix Morindae Officinalis, Olibanum, Herba Ecliptae, Fructus Hippophae, Rhizoma Polygoni Cuspidati, Radix Changii, Caulis Bambusae In Taenia, Rhizoma Acori Graminei and Cortex Lycii.

Further, described pharmaceutical preparation is only made up of above-mentioned raw materials medicine.

In described pharmaceutical preparation, the weight of each crude drug is respectively: Radix Salviae Miltiorrhizae 35g～45g, Herba Agrimoniae 10g～20g, Rhizoma Polygonati 30g～40g, Rhizoma Curcumae 25g～35g, Ramulus Cinnamomi 15g～25g, Bulbus Fritillariae Thunbergii 20g～30g, Cortex Mori 15g～25g, Semen Euryales 20g～30g, Herba Morindae Parvifoliae 15g～25g, Spina Gleditsiae 10g～20g, Herba Erodii 15g～25g, Herba Aletridis Khasianae 25g～35g, Herba Silenes conoideae 20g～30g, Chinese liquor grass 20g～30g, Radix Asparagi 35g～45g, Leucas mollissima Wall. 15g～25g, Folium Eriobotryae 15g～25g, Rhizoma Anemarrhenae 25g～35g, Radix Glehniae 30g～40g, Herba Ephedrae 15g～25g, Fructus Trichosanthis 10g～20g, Radix Morindae Officinalis 15g～25g, Olibanum 10g～20g, Herba Ecliptae 25g～35g, Fructus Hippophae 15g～25g, Rhizoma Polygoni Cuspidati 30g～40g, Radix Changii 25g～35g, Caulis Bambusae In Taenia 20g～30g, Rhizoma Acori Graminei 30g～40g and Cortex Lycii 25g～35g.

Further preferably, in described pharmaceutical preparation, the weight of each crude drug is respectively: Radix Salviae Miltiorrhizae 35g～40g, Herba Agrimoniae 10g～15g, Rhizoma Polygonati 30g～35g, Rhizoma Curcumae 25g～30g, Ramulus Cinnamomi 15g～20g, Bulbus Fritillariae Thunbergii 20g～25g, Cortex Mori 15g～20g, Semen Euryales 20g～25g, Herba Morindae Parvifoliae 15g～20g, Spina Gleditsiae 10g～15g, Herba Erodii 15g～20g, Herba Aletridis Khasianae 30g～35g, Herba Silenes conoideae 25g～30g, Chinese liquor grass 25g～30g, Radix Asparagi 40g～45g, Leucas mollissima Wall. 20g～25g, Folium Eriobotryae 20g～25g, Rhizoma Anemarrhenae 30g～35g, Radix Glehniae 35g～40g, Herba Ephedrae 20g～25g, Fructus Trichosanthis 15g～20g, Radix Morindae Officinalis 20g～25g, Olibanum 15g～20g, Herba Ecliptae 30g～35g, Fructus Hippophae 20g～25g, Rhizoma Polygoni Cuspidati 35g～40g, Radix Changii 30g～35g, Caulis Bambusae In Taenia 25g～30g, Rhizoma Acori Graminei 35g～40g and Cortex Lycii 30g～35g.

Most preferably, in described pharmaceutical preparation, the weight of each crude drug is respectively: Radix Salviae Miltiorrhizae 40g, Herba Agrimoniae 15g, Rhizoma Polygonati 35g, Rhizoma Curcumae 30g, Ramulus Cinnamomi 20g, Bulbus Fritillariae Thunbergii 25g, Cortex Mori 20g, Semen Euryales 25g, Herba Morindae Parvifoliae 20g, Spina Gleditsiae 15g, Herba Erodii 20g, Herba Aletridis Khasianae 30g, Herba Silenes conoideae 25g, Chinese liquor grass 25g, Radix Asparagi 40g, Leucas mollissima Wall. 20g, Folium Eriobotryae 20g, Rhizoma Anemarrhenae 30g, Radix Glehniae 35g, Herba Ephedrae 20g, Fructus Trichosanthis 15g, Radix Morindae Officinalis 20g, Olibanum 15g, Herba Ecliptae 30g, Fructus Hippophae 20g, Rhizoma Polygoni Cuspidati 30g, Radix Changii 25g, Caulis Bambusae In Taenia 20g, Rhizoma Acori Graminei 30g and Cortex Lycii 25g.

Described pharmaceutical preparation can be prepared into granule and capsule.

The present invention also provides the preparation method of said medicine preparation, in the time that prepared pharmaceutical preparation is granule, is specially:

The first step, gets Rhizoma Polygonati, Semen Euryales, Herba Aletridis Khasianae, Radix Asparagi, Radix Glehniae and Herba Ecliptae, pulverizes respectively, mix by above-mentioned weight, it is that in 85%～95% ethanol, the addition of the ethanol that every 100g mixture is corresponding is 300g that the mixture after mix homogeneously is dissolved in to determining alcohol, flood 24 hours～36 hours, adopt subsequently the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and is dried, and obtains the first powder;

Second step, Ramulus Cinnamomi, Bulbus Fritillariae Thunbergii, Herba Morindae Parvifoliae, Chinese liquor grass, the Rhizoma Anemarrhenae, Fructus Trichosanthis, Rhizoma Polygoni Cuspidati, Radix Changii, Caulis Bambusae In Taenia, Rhizoma Acori Graminei and Cortex Lycii are pulverized respectively, mixed by above-mentioned weight, it is the Chinese liquor of 50 DEG C～60 DEG C that the mixture after the mix homogeneously that every 100g obtains is put into 400ml alcoholic strength, sealing is soaked 15～20 days, subsequent boiling 1 hour～3 hours, leaves standstill 12 hours, filters, the filtrate obtaining is concentrated into removes all Chinese liquor, pulverize and be dried, obtain the second powder, filtering residue is for subsequent use;

The 3rd step, pulverizes remaining component respectively, mixes by above-mentioned weight, obtain mixture, this mixture of every 300g, adds 1L～2L water, heating decocts 3 hours～5 hours, and decoction liquor is filtered, and filtering residue mixes with the filtering residue that second step obtains, the filtering residue that every 300g mixes adds 1L～2L water, heating decocts 2 hours～4 hours, and decoction liquor is filtered, and the filtrate after filtering is concentrated into and removes all water, pulverize sick being dried, obtain the 3rd powder;

The 4th step; the first powder, the second powder, the 3rd powder are mixed; the powder of mixing is added to mass percent 20%～30% cane sugar powder with respect to mixed-powder quality; taking determining alcohol as 75%～85% ethanol soft material processed, granulate with oscillating granulator, at 60 DEG C, dry; granulate; obtain medicinal granule, splitting splendid attire, every bag of 10g.

The present invention also provides the preparation method of said medicine preparation, in the time that prepared pharmaceutical preparation is granule, is specially:

The first step, gets Rhizoma Polygonati, Semen Euryales, Herba Aletridis Khasianae, Radix Asparagi, Radix Glehniae and Herba Ecliptae, pulverizes respectively, mix by above-mentioned weight, it is that in 85%～95% ethanol, the addition of the ethanol that every 100g mixture is corresponding is 300g that the mixture after mix homogeneously is dissolved in to determining alcohol, flood 24 hours～36 hours, adopt subsequently the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and is dried, and obtains the first powder;

Second step, Ramulus Cinnamomi, Bulbus Fritillariae Thunbergii, Herba Morindae Parvifoliae, Chinese liquor grass, the Rhizoma Anemarrhenae, Fructus Trichosanthis, Rhizoma Polygoni Cuspidati, Radix Changii, Caulis Bambusae In Taenia, Rhizoma Acori Graminei and Cortex Lycii are pulverized respectively, mixed by above-mentioned weight, it is the Chinese liquor of 50 DEG C～60 DEG C that the mixture after the mix homogeneously that every 100g obtains is put into 400ml alcoholic strength, sealing is soaked 15～20 days, subsequent boiling 1 hour～3 hours, leaves standstill 12 hours, filters, the filtrate obtaining is concentrated into removes all Chinese liquor, pulverize and be dried, obtain the second powder, filtering residue is for subsequent use;

The 3rd step, pulverizes remaining component respectively, mixes by above-mentioned weight, obtain mixture, this mixture of every 300g, adds 1L～2L water, heating decocts 3 hours～5 hours, and decoction liquor is filtered, and filtering residue mixes with the filtering residue that second step obtains, the filtering residue that every 300g mixes adds 1L～2L water, heating decocts 2 hours～4 hours, and decoction liquor is filtered, and the filtrate after filtering is concentrated into and removes all water, pulverize sick being dried, obtain the 3rd powder;

The 4th step, the first powder, the second powder, the 3rd powder are mixed, the mixture obtaining is mixed homogeneously with starch, the amount of starch that every 100g mix products adds is 100g, add determining alcohol and be 25% alcohol granulation, the quality of the ethanol adding is equivalent to 0.1～0.2 times of mixture quality of mix products and starch, by particle drying, add magnesium stearate, the weight of magnesium stearate is equivalent to 0.01～0.02 times of mixture quality of mix products and starch, mix homogeneously, packs into in capsule, obtains capsule.

The pharmacology of described each crude drug is as follows:

Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, GUIXIN, Liver Channel, have promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, effect of nourishing blood to tranquillize the mind, cures mainly menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the cards such as angina pectoris.

Herba Agrimoniae: latin name Agrimoniae Herba, bitter in the mouth, puckery, property is flat, GUIXIN, Liver Channel, have astringing to arrest bleeding, effect of dysentery relieving parasite killing, cures mainly various hemorrhage cards, for example: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage.

Rhizoma Polygonati: sweet in the mouth, property is flat, enters lung, spleen, kidney channel, has the yin nourishing of fostering the spirit of nobility, spleen invigorating lung moistening, the effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, the quenching one's thirst of yin asthenia generating intrinsic heat, the cards such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

Rhizoma Curcumae: acrid in the mouth, hardship, warm in nature, enter liver, spleen channel, there is removing blood stasis circulation of qi promoting, effect of removing food stagnancy pain relieving, for the lump in the abdomen mass in the abdomen of caused by energy stagnation and blood stasis, breast abdomen stasis of blood pain, amenorrhea, dysmenorrhea, abdominal distention, traumatic injury, the blood stasis card such as swell and ache.

Ramulus Cinnamomi: latin name cinnamomi ramulus is the dry twig of canella Cortex Cinnamomi, acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel, have diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effect of dispersing cold for relieving pain, warming the meridian and promoting blood circulation, horizontal logical podomere, for affection of exogenous wind-cold exterior syndrome, no matter have antiperspirant, losslessly all can apply, also for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, dysmenorrhea, rheumatic arthralgia, the cards such as shoulder arm podomere cold type of pain, phlegm retention syndrome and bladder water-retention, heart deficiency of spleen-YANG, retention of water-damp in the body, fullness and distention in the chest and hypochondrium, the dizzy phlegm retention syndrome that waits of cough with dyspnea.

Bulbus Fritillariae Thunbergii: bitter in the mouth, cold in nature, enter lung, heart channel, there is removing heat-phlegm, effect of powder detoxifcation, cures mainly cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, the cards such as sore swollen toxin.

Cortex Mori: sweet in the mouth, cold in nature, enter lung meridian, have eliminating pathogen from the lung for relieving asthma, the effect of inducing diuresis to remove edema, is one of common drug of eliminating the pathogens from the lung row water, be mainly used in the dyspnea with rapid respiration and cough that the strongly fragrant lung of pathogenic heat, QI rising in reverse order do not fall, excessive phlegm, yellow skin, in phlegm retention, stop, the distension cough with dyspnea that breast sun is not declared, Lung Qi obstraction, steam do not walk to edema dyspnea with fullness of the chest; dysuria; function of gallbladder promoting, promote the production of body fluid, the cards such as eliminating stagnation.

Semen Euryales: sweet in the mouth, puckery, property is flat.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, insufficiency of the spleen nebulousurine, is with inferior card.

Herba Morindae Parvifoliae: be the Herb of Rubiaceae Morinda plant spire Radix Morindae Officinalis, sweet in the mouth, cool in nature, there is clearing and antitussive, stomach function regulating removing dampness, effect of eliminating stasis to stop pain, cures mainly cold cough, pertussis, dyspepsia, eczema, traumatic injury, the cards such as lumbar muscle strain.

Spina Gleditsiae: acrid in the mouth, warm in nature, return lung meridian, cure mainly swollen ulcer drug, scrofula, skin ulcer rash stubborn dermatitis, puerperal hypogalactia, placenta retention, the cards such as leprosy.

Herba Erodii: acrid in the mouth, hardship, property is flat, returns liver,kidney,spleen warp, has wind-damp dispelling, the meridian dredging, effect of antidiarrheal profit, for rheumatic arthralgia, numbness contracture, the card such as muscles and bones is ached, dysentery.

Herba Aletridis Khasianae: be the herb of Liliaceae alertris spicata platymiscium Honoka alertris spicata, acrid in the mouth, micro-hardship, warm in nature, return lung, spleen channel, there is tonify deficiency arresting sweating, effect of hemostasis, cures mainly the empty spontaneous perspiration of body, night sweat, neurasthenia, spits blood, the card such as have blood in stool.

Herba Silenes conoideae: sweet in the mouth, micro-hardship, cool in nature, return lung, Liver Channel, there is replenishing YIN and removing heat, effect of blood-arresting catamenia-regulating, cures mainly the cards such as haematemesis, hemoptysis, hematuria, menoxenia, the old cough of Xu.

Chinese liquor grass: bitter in the mouth, pungent, cold in nature, there is clearing away heat to alleviate pain, effect of dispelling pathogenic wind and eliminating phlegm, cures mainly laryngitis, pneumonia, laryngopharynx swelling and pain, the cards such as tonsillitis.

Radix Asparagi: sweet in the mouth, hardship, cold in nature, return lung, kidney channel, there is nourishing YIN to relieve dryness, effect that lung heat clearing is promoted the production of body fluid, cures mainly cough caused by dryness-heat, deficiency of YIN chronic cough, hyperactivity of fire caused by deficiency of YIN, the laryngopharynx swelling and pain of not solid seminal emission, premature ejaculation and the hyperactivity of deficient fire of kidney essense, calentura Tianjin wound is thirsty, the interior-heat cards such as dryness of the intestine constipation of quenching one's thirst.

Leucas mollissima Wall.: bitter in the mouth; Micro-pungent; Property is put down, and has lung heat clearing; Improving eyesight; Effect of removing toxic substances, cures mainly cough due to lung-heat; Chest pain; Laryngopharynx swelling and pain; Conjunctival congestion optic atrohic blindness; Acute mastitis; Eczema; The cards such as traumatic injury.

Folium Eriobotryae: bitter in the mouth, cold nature, returns lung, stomach warp, has clearing away lung-heat to relieve cough, effect of stopping nausea and vomiting by lowering the adverse flow of QI, this product bitter cold, energy clearing away lung-heat, falls lung qi with cough-relieving, be usually used in treating cough due to lung-heat, abundant expectoration yellow skin, can gastric qi be fallen and preventing or arresting vomiting is contrary, the vomiting causing for gastric heat, and treatment xerostomia is quenched one's thirst, lung-wind syndrome acne vulgaris, acne.

The Rhizoma Anemarrhenae: latin name Anemarrhenae Rhizoma, bitter in the mouth, sweet, cold in nature, enter lung, stomach, kidney channel, there is the relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, property sedimentation, can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also be used for the treatment of diabetes; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the cards such as hyperactivity of deficient fire.

Radix Glehniae: cold nature, sweet in the mouth, micro-hardship, have nourishing YIN and clearing away lung-heat, and effect of reinforcing stomach reg fluid cures mainly the cards such as lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound be thirsty.

Herba Ephedrae: acrid in the mouth, micro-hardship, warm in nature, enter lung, urinary bladder channel, have and send out cold inducing sweat, depressed lung-energy dispersing, the effect of inducing diuresis to remove edema, is mainly used in the exterior excess syndrome such as fever without perspiration of affection of exogenous wind-cold; Rheumatic arthralgia pain; Pathogenic cold attacking the lung or accumulation of heat in the lung are to cough with asthma QI rising in reverse order, edema, the cards such as dysuria.

Fructus Trichosanthis: sweet in the mouth, micro-hardship, cold in nature, enter lung, stomach, large intestine channel, there is removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, effect of loosening bowel to relieve constipation, for cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, the card such as acute appendicitis swells and ache, constipation.

Radix Morindae Officinalis: acrid in the mouth, sweet, warm in nature, return liver, kidney channel, there is reinforcing the kidney and supporting YANG; Bone and muscle strengthening; Effect of expelling wind and removing dampness, cures mainly impotence due to deficiency of the kidney; Seminal emission premature ejaculation; Few abdomen cold type of pain; Incontinence of urine; Cold womb is infertile; Anemofrigid-damp arthralgia; Soreness of the waist and knees; The cards such as rheumatism limb gas.

Olibanum: acrid in the mouth, hardship, warm in nature, GUIXIN, liver, spleen channel, have and invigorate blood circulation, and effect of circulation of qi promoting, pain relieving cures mainly the epigastric pain of the stasis blocking stagnation of QI, rheumatic arthralgia, traumatic injury, dysmenorrhea, the cards such as puerperal abdonimal pain.

Herba Ecliptae: latin name Ecliptae Herba, sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, effect of cooling blood for hemostasis, cure mainly due to the hepatic and renal YIN deficiency have a dizzy spell, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, the haematemesis of accumulated heat in stomach, the cards such as the hemoptysis of injury of blood vessel of the lung by heat.

Fructus Hippophae: sour in the mouth; Puckery; Warm in nature, there is relieving cough and resolving phlegm; Invigorating the stomach and promoting digestion; Effect of promoting blood circulation to remove blood stasis.Cure mainly cough with copious phlegm; Pulmonary abscess; Dyspepsia; Abdominal pain due to retention of food; Stomachache; Intestinal inflammation; Amenorrhea; The cards such as traumatic injury congestive edema.

Rhizoma Polygoni Cuspidati: latin name Polygoni Cuspidati Rhizoma etRadix, micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian, there is heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, effect of relieving cough and resolving phlegm, for arthralgia, jaundice due to damp-heat, amenorrhea, leprosy abdominal mass, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, the cards such as carbuncle sore tumefacting virus.

Radix Changii: sweet in the mouth, micro-hardship, cold nature, returns lung, spleen, Liver Channel, has moistening the lung and resolving phlegm, yin nourishing stomach function regulating, effect of suppressing the hyperactive liver removing toxic substances, for cough due to lung-heat, vomiting regurgitation, lack of appetite xerostomia, the card such as conjunctival congestion is dizzy, furunculosis skin infection.

Caulis Bambusae In Taenia: cold nature, sweet in the mouth, attaches to the lung and stomach meridians, and has removing heat-phlegm, and the effect relieving restlessness and preventing vomiting is held the cards such as expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm for phlegm-heat cough, gallbladder fire.

Rhizoma Acori Graminei: acrid in the mouth, warm in nature, enter the heart, stomach warp, has the refreshment of having one's ideas straightened out, and effect of removing dampness to restore normal function of the stomach is used for the treatment of expectorant and covers clear key, and coma is demented, dizziness, insomnia, forgetful, tinnitus, retention of dampness in middle-JIAO, the cards such as abdominal distention.

Cortex Lycii: latin name Lycii Cortex, cold in nature, sweet in the mouth, has removing heat from blood except steaming, and effect of lung heat clearing pathogenic fire reducing, cures mainly the cards such as deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis.

The pharmaceutical preparation that is used for the treatment of chronic obstructive pulmonary disease provided by the invention is more preferably used for the treatment of acute exacerbation of chronic obstructive pulmonary disease.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 granule 1

Get Rhizoma Polygonati 35g, Semen Euryales 25g, Herba Aletridis Khasianae 30g, Radix Asparagi 40g, Radix Glehniae 35g and Herba Ecliptae 30g pulverize respectively, mix, and it is in 95% ethanol that the mixture after mix homogeneously is dissolved in to determining alcohol, the addition of the ethanol that every 100g mixture is corresponding is 300g, flood 24 hours, adopt subsequently the speed slowly percolation of percolation with 2ml per minute, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and is dried, obtain the first powder, by Ramulus Cinnamomi 20g, Bulbus Fritillariae Thunbergii 25g, Herba Morindae Parvifoliae 20g, Chinese liquor grass 25g, Rhizoma Anemarrhenae 30g, Fructus Trichosanthis 15g, Rhizoma Polygoni Cuspidati 30g, Radix Changii 25g, Caulis Bambusae In Taenia 20g, Rhizoma Acori Graminei 30g and Cortex Lycii 25g pulverize respectively, mix, it is the Chinese liquor of 50 DEG C～60 DEG C that the mixture after the mix homogeneously that every 100g obtains is put into 400ml alcoholic strength, and sealing is soaked 20 days, subsequent boiling 3 hours, leave standstill 12 hours, filter, the filtrate of acquisition is concentrated into removes all Chinese liquor, pulverize and be dried, obtain the second powder, filtering residue is for subsequent use, by Radix Salviae Miltiorrhizae 40g, Herba Agrimoniae 15g, Rhizoma Curcumae 30g, Cortex Mori 20g, Spina Gleditsiae 15g, Herba Erodii 20g, Herba Silenes conoideae 25g, Leucas mollissima Wall. 20g, Folium Eriobotryae 20g, Herba Ephedrae 20g, Radix Morindae Officinalis 20g, Olibanum 15g and Fructus Hippophae 20g pulverize respectively, mix, and obtain mixture, this mixture of every 300g, adds 2L water, and heating decocts 5 hours, decoction liquor is filtered, and filtering residue mixes with the filtering residue obtaining above, and the filtering residue that every 300g mixes adds 2L water, heating decocts 4 hours, decoction liquor is filtered, and the filtrate after filtering is concentrated into and removes all water, pulverizes sick dry, obtain the 3rd powder, by the first powder, the second powder, the 3rd powder mixes, and the powder of mixing is added with respect to mixed-powder quality 20% cane sugar powder (mass percent), taking determining alcohol as 85% ethanol soft material processed, granulate with oscillating granulator, at 60 DEG C, dry granulate, obtain medicinal granule, splitting splendid attire, every bag of 10g.

Embodiment 2 granules 2

Get Rhizoma Polygonati 30g, Semen Euryales 20g, Herba Aletridis Khasianae 30g, Radix Asparagi 40g, Radix Glehniae 35g and Herba Ecliptae 30g pulverize respectively, mix, and it is in 95% ethanol that the mixture after mix homogeneously is dissolved in to determining alcohol, the addition of the ethanol that every 100g mixture is corresponding is 300g, flood 24 hours, adopt subsequently the speed slowly percolation of percolation with 2ml per minute, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and is dried, obtain the first powder, by Ramulus Cinnamomi 15g, Bulbus Fritillariae Thunbergii 20g, Herba Morindae Parvifoliae 15g, Chinese liquor grass 25g, Rhizoma Anemarrhenae 30g, Fructus Trichosanthis 15g, Rhizoma Polygoni Cuspidati 30g, Radix Changii 25g, Caulis Bambusae In Taenia 20g, Rhizoma Acori Graminei 30g and Cortex Lycii 25g pulverize respectively, mix, it is the Chinese liquor of 50 DEG C～60 DEG C that the mixture after the mix homogeneously that every 100g obtains is put into 400ml alcoholic strength, and sealing is soaked 20 days, subsequent boiling 3 hours, leave standstill 12 hours, filter, the filtrate of acquisition is concentrated into removes all Chinese liquor, pulverize and be dried, obtain the second powder, filtering residue is for subsequent use, by Radix Salviae Miltiorrhizae 35g, Herba Agrimoniae 10g, Rhizoma Curcumae 25g, Cortex Mori 15g, Spina Gleditsiae 10g, Herba Erodii 15g, Herba Silenes conoideae 25g, Leucas mollissima Wall. 20g, Folium Eriobotryae 20g, Herba Ephedrae 20g, Radix Morindae Officinalis 20g, Olibanum 15g and Fructus Hippophae 20g pulverize respectively, mix, and obtain mixture, this mixture of every 300g, adds 2L water, and heating decocts 5 hours, decoction liquor is filtered, and filtering residue mixes with the filtering residue obtaining above, and the filtering residue that every 300g mixes adds 2L water, heating decocts 4 hours, decoction liquor is filtered, and the filtrate after filtering is concentrated into and removes all water, pulverizes sick dry, obtain the 3rd powder, by the first powder, the second powder, the 3rd powder mixes, and the powder of mixing is added with respect to mixed-powder quality 20% cane sugar powder (mass percent), taking determining alcohol as 85% ethanol soft material processed, granulate with oscillating granulator, at 60 DEG C, dry granulate, obtain medicinal granule, splitting splendid attire, every bag of 10g.

Embodiment 3 granules 3

Get Rhizoma Polygonati 35g, Semen Euryales 25g, Herba Aletridis Khasianae 25g, Radix Asparagi 35g, Radix Glehniae 30g and Herba Ecliptae 25g pulverize respectively, mix, and it is in 95% ethanol that the mixture after mix homogeneously is dissolved in to determining alcohol, the addition of the ethanol that every 100g mixture is corresponding is 300g, flood 24 hours, adopt subsequently the speed slowly percolation of percolation with 2ml per minute, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and is dried, obtain the first powder, by Ramulus Cinnamomi 20g, Bulbus Fritillariae Thunbergii 25g, Herba Morindae Parvifoliae 20g, Chinese liquor grass 30g, Rhizoma Anemarrhenae 30g, Fructus Trichosanthis 20g divides, Rhizoma Polygoni Cuspidati 35g, Radix Changii 30g, Caulis Bambusae In Taenia 25g, Rhizoma Acori Graminei 35g and Cortex Lycii 30g do not pulverize, mix, it is the Chinese liquor of 50 DEG C～60 DEG C that the mixture after the mix homogeneously that every 100g obtains is put into 400ml alcoholic strength, and sealing is soaked 20 days, subsequent boiling 3 hours, leave standstill 12 hours, filter, the filtrate of acquisition is concentrated into removes all Chinese liquor, pulverize and be dried, obtain the second powder, filtering residue is for subsequent use, by Radix Salviae Miltiorrhizae 40g, Herba Agrimoniae 15g, Rhizoma Curcumae 30g, Cortex Mori 20g, Spina Gleditsiae 15g, Herba Erodii 20g, Herba Silenes conoideae 20g, Leucas mollissima Wall. 15g, Folium Eriobotryae 15g, Herba Ephedrae 15g, Radix Morindae Officinalis 15g, Olibanum 10g and Fructus Hippophae 15g pulverize respectively, mix, and obtain mixture, this mixture of every 300g, adds 2L water, and heating decocts 5 hours, decoction liquor is filtered, and filtering residue mixes with the filtering residue obtaining above, and the filtering residue that every 300g mixes adds 2L water, heating decocts 4 hours, decoction liquor is filtered, and the filtrate after filtering is concentrated into and removes all water, pulverizes sick dry, obtain the 3rd powder, by the first powder, the second powder, the 3rd powder mixes, and the powder of mixing is added with respect to mixed-powder quality 20% cane sugar powder (mass percent), taking determining alcohol as 85% ethanol soft material processed, granulate with oscillating granulator, at 60 DEG C, dry granulate, obtain medicinal granule, splitting splendid attire, every bag of 10g.

Embodiment 4 capsules 1

Get Rhizoma Polygonati 35g, Semen Euryales 25g, Herba Aletridis Khasianae 30g, Radix Asparagi 40g, Radix Glehniae 35g and Herba Ecliptae 30g pulverize respectively, mix, and it is in 95% ethanol that the mixture after mix homogeneously is dissolved in to determining alcohol, the addition of the ethanol that every 100g mixture is corresponding is 300g, flood 24 hours, adopt subsequently the speed slowly percolation of percolation with 2ml per minute, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and is dried, obtain the first powder, by Ramulus Cinnamomi 20g, Bulbus Fritillariae Thunbergii 25g, Herba Morindae Parvifoliae 20g, Chinese liquor grass 25g, Rhizoma Anemarrhenae 30g, Fructus Trichosanthis 15g, Rhizoma Polygoni Cuspidati 30g, Radix Changii 25g, Caulis Bambusae In Taenia 20g, Rhizoma Acori Graminei 30g and Cortex Lycii 25g pulverize respectively, mix, it is the Chinese liquor of 50 DEG C～60 DEG C that the mixture after the mix homogeneously that every 100g obtains is put into 400ml alcoholic strength, and sealing is soaked 20 days, subsequent boiling 3 hours, leave standstill 12 hours, filter, the filtrate of acquisition is concentrated into removes all Chinese liquor, pulverize and be dried, obtain the second powder, filtering residue is for subsequent use, by Radix Salviae Miltiorrhizae 40g, Herba Agrimoniae 15g, Rhizoma Curcumae 30g, Cortex Mori 20g, Spina Gleditsiae 15g, Herba Erodii 20g, Herba Silenes conoideae 25g, Leucas mollissima Wall. 20g, Folium Eriobotryae 20g, Herba Ephedrae 20g, Radix Morindae Officinalis 20g, Olibanum 15g and Fructus Hippophae 20g pulverize respectively, mix, and obtain mixture, this mixture of every 300g, adds 2L water, and heating decocts 5 hours, decoction liquor is filtered, and filtering residue mixes with the filtering residue obtaining above, and the filtering residue that every 300g mixes adds 2L water, heating decocts 4 hours, decoction liquor is filtered, and the filtrate after filtering is concentrated into and removes all water, pulverizes sick dry, obtain the 3rd powder, by the first powder, the second powder, the 3rd powder mixes, the mixture obtaining is mixed homogeneously with starch, the amount of starch that every 100g mix products adds is 100g, adds determining alcohol and be 25% alcohol granulation, and the quality of the ethanol adding is equivalent to 0.1 times of mixture quality of mix products and starch, by particle drying, add magnesium stearate, the weight of magnesium stearate is equivalent to 0.01 times of mixture quality of mix products and starch, mix homogeneously, pack into in capsule, obtain capsule.

Embodiment 5 toxicology tests

Choose 60 of ICR mices, be divided into blank group and treatment group, 30 every group.

Experimental agents

Granule 1 prepared by the mouse stomach embodiment of the present invention 1.

Chmice acute toxicity test

By treatment group mice according to method administration above, granule 1 is dissolved in water, be prepared into the solution gavage of 1g/ml, each gavage 0.8ml/10g, blank group gavage equivalent normal saline, after front fasting (the can't help water) 12h of test, treatment group 1 gastric infusion every day, 14d, records the situations such as tested mice behavior, activity, food ration, body weight, feces, death continuously, and not dead mice is put to death and performs an autopsy on sb． after 14d.

The mice of Chinese medicine composition 80g (crude drug)/kg dosed administration, saw that mice hair color was smooth, feces is brown the same day, quality is rarer soft, ingest, movable less, mice activity after the 2nd day, food ration, body weight gain, feces etc. all recover normally, with relatively no significant difference of blank group; And in 14d without dead and other extremely occurs, two groups perform an autopsy on sb． after putting to death simultaneously, each main organs (heart, liver, spleen, lung, kidney) no abnormality seen by the naked eye.

Cavia porcellus repetitively administered toxicity test

Granule 1 is dissolved in water, be prepared into the solution of 1g/ml, by administration group Cavia porcellus according to method administration above, each 0.8ml/10g, blank group gavage equivalent normal saline, after front fasting (the can't help water) 12h of test, treatment group 1 gastric infusion every day, continuous 5 weeks, record the situations such as tested Cavia porcellus behavior, activity, food ration, body weight, feces, death, Guinea Pigs Died was not put to death and is performed an autopsy on sb． after 5 weeks.

Experimental animal behavioral activity, diet, defecation and shown no obvious abnormalities by situations such as hair color pools within whole experimental period, have no vomiting, sialorrhea, shed tears, the symptom such as dyspnea.Duration of test has indivedual animal deads, takes up Anatomical Observation through cage, and dead animal shows no obvious abnormalities, for administration improper lethal.

After the administration of administration treated animal, growth promoter is good, and body weight gain and blank group relatively show no obvious abnormalities.

After off-test, put to death animal, dissect immediately, the major organs such as perusal brain, heart, liver, spleen, lungs, kidney, each organ surface is smooth, without adhesion, color and luster is normal, has no hyperemia, swelling, hemorrhage, downright bad, adhesion, gastrointestinal is without expansion, and intestinal wall is without abnormal phenomenas such as edema, hemorrhage, ulcer.

Heart: myocardial cell band is clear, and core is placed in the middle, interstitial has no vasodilation and cell infiltration; Visceral pericardium, endocardium are without extremely.Liver: hepatocyte is arranged and is strand, and lobules of liver structure is clear, and portal area has no cell infiltration and fibrous connective tissue hypertrophy, hepatocyte polygon, slurry is abundant, and core is justified greatly.Spleen: fibrous capsule is complete, without thickening, acini lienalis is high-visible, and trabecularism is normal, and red pulp, white pulp are clear, have no degeneration, necrosis and cell infiltration.Lungs: bronchioles structural integrity, be methodically arranged, alveolar wall structural integrity, lung interval and bronchus are excellent, and intracavity, without obvious exudate, has no degeneration, necrosis and cell infiltration.Kidney: Renal Cortex, medullary substance, glomerule structure are normal, and messangial cell number does not increase, blood capillary tube chamber is without expansion, renal cells, kidney interstitial no abnormality seen.Brain: organizational structure is normal, neurocyte, neurogliocyte form are normal, each layer of neuronal cell Non Apparent Abnormality.

Above-mentioned evidence Chinese medicine composition avirulence provided by the invention, is suitable for Secure Application.

Embodiment 6 clinical datas

Physical data

Select in December, 2011 to 2014 to move in COPD Acute Exacerbation Period patient 130 examples of undergraduate course year March, with reference to Ministry of Health of the People's Republic of China " diagnosis of chronic obstructive pulmonary disease standard (2010-301) ".160 routine patients are divided into treatment group and matched group at random, treatment group 70 examples, male's 36 examples, women's 34 examples, 57.62 ± 2.35 years old mean age; Matched group 50 examples, male's 27 examples, women's 23 examples, 55.39 ± 2.51 years old mean age.All get rid of the patient who is associated with asthma, hypertension, coronary heart disease, arrhythmia, heart failure, diabetes and needs mechanical ventilation for two groups; Two groups of patients there are no significant at aspects such as sex, age, courses of disease difference (P > 0.05).

Therapeutic Method

Matched group: by antiinflammatory, spasmolytic, reduce phlegm, the conventional therapy such as energy, oxygen uptake if desired.The treatment group granule that on the basis of matched group prepared by the oral embodiment of the present invention 1, is dissolved in water, is configured to the solution of 1g/ml, oral, and every day 3 times, each 100ml, a course for the treatment of of 10d, observes a course for the treatment of.

Criterion of therapeutical effect

" the sick Standardization of diagnosis and curative effect of tcm clinical practice " promulgated with reference to State Administration of Traditional Chinese Medicine.Clinical recovery: the symptoms such as cough, expectoration, dyspnea and pulmonary's sound of vomiting sound all disappear.Effective: the symptoms such as cough, expectoration, dyspnea are clearly better, pulmonary's sound of vomiting sound disappears or obviously alleviates.Take a turn for the better: the symptoms such as cough, expectoration, dyspnea take a turn for the better, pulmonary's sound of vomiting sound reduces.Invalid: cough, the symptom such as expectorant, dyspnea is not obvious without changing or alleviating, and pulmonary's sound of vomiting sound to be without reducing or increasing.

Lab testing

With pulmonary function, blood gas analysis and other experimental checks, as the reference index of therapeutic effect assessment.

Statistical method

Measurement data adopts represent, between group, relatively adopt chi-square criterion, all data all adopt the processing of SPSS12.0 statistical software.

Therapeutic outcome

Two groups of Clinical efficacy comparisons, the results are shown in Table 1.

Clinical efficacy comparison after table 1 liang group treatment

Group	Number of cases	Clinical recovery	Effective	Take a turn for the better	Invalid
						Treatment group	70	49(70.0％)	18(25.7％)	3(4.3％)	0(0.0％)
Matched group	50	14(28.0％)	26(52.0％)	10(20.0％)	0(0.0％)

As can be seen from Table 1, Chinese medicine preparation of the present invention coordinates Western medicine to use, and therapeutic effect will be significantly better than matched group.

Two groups of Pulmonary Functions are measured relatively, the results are shown in Table 2.

FEV before and after table 2 liang group treatment ₁, FEV ₁/ FVC comparison

As can be seen from Table 2, treatment group and matched group FEV before treatment ₁, FEV ₁/ FVC is without significant difference, and after treating, with treatment obvious difference (P < 0.05) before, treatment is the FEV for the treatment of group afterwards ₁, FEV ₁/ FVC value is all higher than matched group (P < 0.05).

Two groups of patient's blood gas analysis detect relatively, the results are shown in Table 3.

PaO before and after table 3 liang group treatment ₂, PaCO ₂relatively

As can be seen from Table 2, treatment group and matched group PaO before treatment ₂, PaCO ₂without significant difference, after treating, with treatment obvious difference (P < 0.05) before, treatment is the PaO for the treatment of group afterwards ₂be significantly higher than matched group (P < 0.05), PaCO ₂significantly lower than matched group (P < 0.05).

All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing amendment, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (7)

1. be used for the treatment of a pharmaceutical preparation for chronic obstructive pulmonary disease, it is characterized in that: crude drug comprises Radix Salviae Miltiorrhizae, Herba Agrimoniae, Rhizoma Polygonati, Rhizoma Curcumae, Ramulus Cinnamomi, Bulbus Fritillariae Thunbergii, Cortex Mori, Semen Euryales, Herba Morindae Parvifoliae, Spina Gleditsiae, Herba Erodii, Herba Aletridis Khasianae, Herba Silenes conoideae, Chinese liquor grass, Radix Asparagi, Leucas mollissima Wall., Folium Eriobotryae, the Rhizoma Anemarrhenae, Radix Glehniae, Herba Ephedrae, Fructus Trichosanthis, Radix Morindae Officinalis, Olibanum, Herba Ecliptae, Fructus Hippophae, Rhizoma Polygoni Cuspidati, Radix Changii, Caulis Bambusae In Taenia, Rhizoma Acori Graminei and Cortex Lycii.

2. pharmaceutical preparation as claimed in claim 1, it is characterized in that: the weight of each crude drug is respectively Radix Salviae Miltiorrhizae 35g～45g, Herba Agrimoniae 10g～20g, Rhizoma Polygonati 30g～40g, Rhizoma Curcumae 25g～35g, Ramulus Cinnamomi 15g～25g, Bulbus Fritillariae Thunbergii 20g～30g, Cortex Mori 15g～25g, Semen Euryales 20g～30g, Herba Morindae Parvifoliae 15g～25g, Spina Gleditsiae 10g～20g, Herba Erodii 15g～25g, Herba Aletridis Khasianae 25g～35g, Herba Silenes conoideae 20g～30g, Chinese liquor grass 20g～30g, Radix Asparagi 35g～45g, Leucas mollissima Wall. 15g～25g, Folium Eriobotryae 15g～25g, Rhizoma Anemarrhenae 25g～35g, Radix Glehniae 30g～40g, Herba Ephedrae 15g～25g, Fructus Trichosanthis 10g～20g, Radix Morindae Officinalis 15g～25g, Olibanum 10g～20g, Herba Ecliptae 25g～35g, Fructus Hippophae 15g～25g, Rhizoma Polygoni Cuspidati 30g～40g, Radix Changii 25g～35g, Caulis Bambusae In Taenia 20g～30g, Rhizoma Acori Graminei 30g～40g and Cortex Lycii 25g～35g.

3. pharmaceutical preparation as claimed in claim 1 or 2, it is characterized in that: the weight of each crude drug is respectively Radix Salviae Miltiorrhizae 35g～40g, Herba Agrimoniae 10g～15g, Rhizoma Polygonati 30g～35g, Rhizoma Curcumae 25g～30g, Ramulus Cinnamomi 15g～20g, Bulbus Fritillariae Thunbergii 20g～25g, Cortex Mori 15g～20g, Semen Euryales 20g～25g, Herba Morindae Parvifoliae 15g～20g, Spina Gleditsiae 10g～15g, Herba Erodii 15g～20g, Herba Aletridis Khasianae 30g～35g, Herba Silenes conoideae 25g～30g, Chinese liquor grass 25g～30g, Radix Asparagi 40g～45g, Leucas mollissima Wall. 20g～25g, Folium Eriobotryae 20g～25g, Rhizoma Anemarrhenae 30g～35g, Radix Glehniae 35g～40g, Herba Ephedrae 20g～25g, Fructus Trichosanthis 15g～20g, Radix Morindae Officinalis 20g～25g, Olibanum 15g～20g, Herba Ecliptae 30g～35g, Fructus Hippophae 20g～25g, Rhizoma Polygoni Cuspidati 35g～40g, Radix Changii 30g～35g, Caulis Bambusae In Taenia 25g～30g, Rhizoma Acori Graminei 35g～40g and Cortex Lycii 30g～35g.

4. the pharmaceutical preparation as described in claims 1 to 3, it is characterized in that: the weight of each crude drug is respectively Radix Salviae Miltiorrhizae 40g, Herba Agrimoniae 15g, Rhizoma Polygonati 35g, Rhizoma Curcumae 30g, Ramulus Cinnamomi 20g, Bulbus Fritillariae Thunbergii 25g, Cortex Mori 20g, Semen Euryales 25g, Herba Morindae Parvifoliae 20g, Spina Gleditsiae 15g, Herba Erodii 20g, Herba Aletridis Khasianae 30g, Herba Silenes conoideae 25g, Chinese liquor grass 25g, Radix Asparagi 40g, Leucas mollissima Wall. 20g, Folium Eriobotryae 20g, Rhizoma Anemarrhenae 30g, Radix Glehniae 35g, Herba Ephedrae 20g, Fructus Trichosanthis 15g, Radix Morindae Officinalis 20g, Olibanum 15g, Herba Ecliptae 30g, Fructus Hippophae 20g, Rhizoma Polygoni Cuspidati 30g, Radix Changii 25g, Caulis Bambusae In Taenia 20g, Rhizoma Acori Graminei 30g and Cortex Lycii 25g.

5. the pharmaceutical preparation as described in claim 1 to 4, is characterized in that: described pharmaceutical preparation can be prepared into granule and capsule.

6. the preparation method of pharmaceutical preparation described in claim 1 to 4, is characterized in that: in the time that prepared pharmaceutical preparation is granule, is specially,

The first step, gets Rhizoma Polygonati, Semen Euryales, Herba Aletridis Khasianae, Radix Asparagi, Radix Glehniae and Herba Ecliptae, pulverizes respectively, mix by above-mentioned weight, it is that in 85%～95% ethanol, the addition of the ethanol that every 100g mixture is corresponding is 300g that the mixture after mix homogeneously is dissolved in to determining alcohol, flood 24 hours～36 hours, adopt subsequently the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and is dried, and obtains the first powder;

Second step, Ramulus Cinnamomi, Bulbus Fritillariae Thunbergii, Herba Morindae Parvifoliae, Chinese liquor grass, the Rhizoma Anemarrhenae, Fructus Trichosanthis are pulverized respectively, mixed by above-mentioned weight, it is the Chinese liquor of 50 DEG C～60 DEG C that the mixture after the mix homogeneously that every 100g obtains is put into 400ml alcoholic strength, sealing is soaked 15～20 days, subsequent boiling 1 hour～3 hours, leaves standstill 12 hours, filters, the filtrate obtaining is concentrated into removes all Chinese liquor, pulverize and be dried, obtain the second powder, filtering residue is for subsequent use;

The 3rd step, pulverizes remaining component respectively, mixes by above-mentioned weight, obtain mixture, this mixture of every 300g, adds 1L～2L water, heating decocts 3 hours～5 hours, and decoction liquor is filtered, and filtering residue mixes with the filtering residue that second step obtains, the filtering residue that every 300g mixes adds 1L～2L water, heating decocts 2 hours～4 hours, and decoction liquor is filtered, and the filtrate after filtering is concentrated into and removes all water, pulverize sick being dried, obtain the 3rd powder;

The 4th step; the first powder, the second powder, the 3rd powder are mixed; the powder of mixing is added to mass percent 20%～30% cane sugar powder with respect to mixed-powder quality; taking determining alcohol as 75%～85% ethanol soft material processed, granulate with oscillating granulator, at 60 DEG C, dry; granulate; obtain medicinal granule, splitting splendid attire, every bag of 10g.

7. the preparation method of pharmaceutical preparation described in claim 1 to 4, is characterized in that: in the time that prepared pharmaceutical preparation is granule, be specially:

The first step, gets Rhizoma Polygonati, Semen Euryales, Herba Aletridis Khasianae, Radix Asparagi, Radix Glehniae and Herba Ecliptae, pulverizes respectively, mix by above-mentioned weight, it is that in 85%～95% ethanol, the addition of the ethanol that every 100g mixture is corresponding is 300g that the mixture after mix homogeneously is dissolved in to determining alcohol, flood 24 hours～36 hours, adopt subsequently the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and is dried, and obtains the first powder;

Second step, Ramulus Cinnamomi, Bulbus Fritillariae Thunbergii, Herba Morindae Parvifoliae, Chinese liquor grass, the Rhizoma Anemarrhenae, Fructus Trichosanthis are pulverized respectively, mixed by above-mentioned weight, it is the Chinese liquor of 50 DEG C～60 DEG C that the mixture after the mix homogeneously that every 100g obtains is put into 400ml alcoholic strength, sealing is soaked 15～20 days, subsequent boiling 1 hour～3 hours, leaves standstill 12 hours, filters, the filtrate obtaining is concentrated into removes all Chinese liquor, pulverize and be dried, obtain the second powder, filtering residue is for subsequent use;

The 3rd step, pulverizes remaining component respectively, mixes by above-mentioned weight, obtain mixture, this mixture of every 300g, adds 1L～2L water, heating decocts 3 hours～5 hours, and decoction liquor is filtered, and filtering residue mixes with the filtering residue that second step obtains, the filtering residue that every 300g mixes adds 1L～2L water, heating decocts 2 hours～4 hours, and decoction liquor is filtered, and the filtrate after filtering is concentrated into and removes all water, pulverize sick being dried, obtain the 3rd powder;

The 4th step, the first powder, the second powder, the 3rd powder are mixed, the mixture obtaining is mixed homogeneously with starch, the amount of starch that every 100g mix products adds is 100g, add determining alcohol and be 25% alcohol granulation, the quality of the ethanol adding is equivalent to 0.1～0.2 times of mixture quality of mix products and starch, by particle drying, add magnesium stearate, the weight of magnesium stearate is equivalent to 0.01～0.02 times of mixture quality of mix products and starch, mix homogeneously, packs into in capsule, obtains capsule.