CN103041160B - Traditional Chinese medicine composition for curing acute pharyngitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for curing acute pharyngitis and preparation method thereof Download PDFInfo
- Publication number
- CN103041160B CN103041160B CN201210593558.6A CN201210593558A CN103041160B CN 103041160 B CN103041160 B CN 103041160B CN 201210593558 A CN201210593558 A CN 201210593558A CN 103041160 B CN103041160 B CN 103041160B
- Authority
- CN
- China
- Prior art keywords
- weight portions
- weight portion
- weight
- portions
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 145
- 239000000203 mixture Substances 0.000 title claims abstract description 79
- 201000007100 Pharyngitis Diseases 0.000 title claims abstract description 64
- 208000016150 acute pharyngitis Diseases 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims description 22
- 229940079593 drug Drugs 0.000 claims abstract description 57
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims abstract description 27
- 235000009926 Dioscorea panthaica Nutrition 0.000 claims abstract description 25
- 241000374766 Dioscorea panthaica Species 0.000 claims abstract description 25
- 241000628997 Flos Species 0.000 claims abstract description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 60
- 239000000843 powder Substances 0.000 claims description 53
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 52
- 239000008187 granular material Substances 0.000 claims description 44
- 239000011347 resin Substances 0.000 claims description 42
- 229920005989 resin Polymers 0.000 claims description 42
- 238000000034 method Methods 0.000 claims description 36
- 239000012153 distilled water Substances 0.000 claims description 29
- 230000008569 process Effects 0.000 claims description 29
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 28
- 239000003463 adsorbent Substances 0.000 claims description 28
- 238000002156 mixing Methods 0.000 claims description 28
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 24
- 244000235603 Acacia catechu Species 0.000 claims description 24
- 235000006226 Areca catechu Nutrition 0.000 claims description 24
- 241000959626 Calvatia Species 0.000 claims description 24
- 210000000582 semen Anatomy 0.000 claims description 24
- 241000229143 Hippophae Species 0.000 claims description 23
- 235000003935 Hippophae Nutrition 0.000 claims description 23
- 238000005507 spraying Methods 0.000 claims description 20
- 239000003826 tablet Substances 0.000 claims description 18
- 230000001105 regulatory effect Effects 0.000 claims description 15
- 239000003480 eluent Substances 0.000 claims description 14
- 238000010828 elution Methods 0.000 claims description 14
- 239000000284 extract Substances 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 14
- 230000002829 reductive effect Effects 0.000 claims description 14
- 238000001179 sorption measurement Methods 0.000 claims description 14
- 229930006000 Sucrose Natural products 0.000 claims description 13
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 13
- FYGDTMLNYKFZSV-MRCIVHHJSA-N dextrin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](CO)OC(O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-MRCIVHHJSA-N 0.000 claims description 13
- 229960004793 sucrose Drugs 0.000 claims description 13
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 12
- 239000002552 dosage form Substances 0.000 claims description 11
- 239000006071 cream Substances 0.000 claims description 9
- 238000011049 filling Methods 0.000 claims description 7
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
- 235000019359 magnesium stearate Nutrition 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 6
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 239000000741 silica gel Substances 0.000 claims description 6
- 229910002027 silica gel Inorganic materials 0.000 claims description 6
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 6
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 6
- 239000007779 soft material Substances 0.000 claims description 6
- 238000001291 vacuum drying Methods 0.000 claims description 6
- -1 mixes Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 3
- 239000007901 soft capsule Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 51
- 208000024891 symptom Diseases 0.000 abstract description 24
- 230000006378 damage Effects 0.000 abstract description 8
- 230000036039 immunity Effects 0.000 abstract description 8
- 241000282414 Homo sapiens Species 0.000 abstract description 7
- 206010059866 Drug resistance Diseases 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 5
- 230000002588 toxic effect Effects 0.000 abstract description 5
- 240000000950 Hippophae rhamnoides Species 0.000 abstract description 2
- 235000003145 Hippophae rhamnoides Nutrition 0.000 abstract description 2
- 230000008901 benefit Effects 0.000 abstract description 2
- 230000000474 nursing effect Effects 0.000 abstract description 2
- 241001116477 Adenophora triphylla Species 0.000 abstract 1
- 241001407408 Berberis fortunei Species 0.000 abstract 1
- 235000002566 Capsicum Nutrition 0.000 abstract 1
- 241000931705 Cicada Species 0.000 abstract 1
- 235000002722 Dioscorea batatas Nutrition 0.000 abstract 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 abstract 1
- 240000001811 Dioscorea oppositifolia Species 0.000 abstract 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 abstract 1
- 235000015489 Emblica officinalis Nutrition 0.000 abstract 1
- 241000218671 Ephedra Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 241001506304 Kadsura japonica Species 0.000 abstract 1
- 241000133231 Marshallia caespitosa Species 0.000 abstract 1
- 235000003174 Panax japonicus Nutrition 0.000 abstract 1
- 241000168720 Panax japonicus Species 0.000 abstract 1
- 239000006002 Pepper Substances 0.000 abstract 1
- 235000016761 Piper aduncum Nutrition 0.000 abstract 1
- 235000017804 Piper guineense Nutrition 0.000 abstract 1
- 244000203593 Piper nigrum Species 0.000 abstract 1
- 235000008184 Piper nigrum Nutrition 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 241000736026 Sarcandra Species 0.000 abstract 1
- 241001571446 Scaphium scaphigerum Species 0.000 abstract 1
- 240000004534 Scutellaria baicalensis Species 0.000 abstract 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract 1
- 244000197975 Solidago virgaurea Species 0.000 abstract 1
- 235000000914 Solidago virgaurea Nutrition 0.000 abstract 1
- 244000277583 Terminalia catappa Species 0.000 abstract 1
- 235000011517 Terminalia chebula Nutrition 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 77
- 210000004072 lung Anatomy 0.000 description 54
- 206010011224 Cough Diseases 0.000 description 50
- 210000004369 blood Anatomy 0.000 description 37
- 239000008280 blood Substances 0.000 description 37
- 210000000214 mouth Anatomy 0.000 description 29
- 208000002193 Pain Diseases 0.000 description 28
- 230000036407 pain Effects 0.000 description 28
- 210000003800 pharynx Anatomy 0.000 description 26
- 230000008961 swelling Effects 0.000 description 20
- 206010062717 Increased upper airway secretion Diseases 0.000 description 19
- 208000026435 phlegm Diseases 0.000 description 19
- 210000002784 stomach Anatomy 0.000 description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 17
- 231100000614 poison Toxicity 0.000 description 17
- 206010068319 Oropharyngeal pain Diseases 0.000 description 16
- 201000010099 disease Diseases 0.000 description 16
- 230000001717 pathogenic effect Effects 0.000 description 16
- 241000700199 Cavia porcellus Species 0.000 description 15
- 210000004185 liver Anatomy 0.000 description 15
- 230000001737 promoting effect Effects 0.000 description 14
- 241001465754 Metazoa Species 0.000 description 11
- 235000009508 confectionery Nutrition 0.000 description 11
- 210000003734 kidney Anatomy 0.000 description 11
- 210000000952 spleen Anatomy 0.000 description 11
- 239000003440 toxic substance Substances 0.000 description 11
- 238000003304 gavage Methods 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 8
- 230000037396 body weight Effects 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- 230000034994 death Effects 0.000 description 8
- 206010012735 Diarrhoea Diseases 0.000 description 7
- 206010061218 Inflammation Diseases 0.000 description 7
- 206010030113 Oedema Diseases 0.000 description 7
- 230000005856 abnormality Effects 0.000 description 7
- 238000010171 animal model Methods 0.000 description 7
- 208000001848 dysentery Diseases 0.000 description 7
- 239000003172 expectorant agent Substances 0.000 description 7
- 230000003419 expectorant effect Effects 0.000 description 7
- 210000002216 heart Anatomy 0.000 description 7
- 238000010438 heat treatment Methods 0.000 description 7
- 230000023597 hemostasis Effects 0.000 description 7
- 208000014674 injury Diseases 0.000 description 7
- 210000002429 large intestine Anatomy 0.000 description 7
- 210000004877 mucosa Anatomy 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 206010018691 Granuloma Diseases 0.000 description 6
- 102000004889 Interleukin-6 Human genes 0.000 description 6
- 238000012449 Kunming mouse Methods 0.000 description 6
- 206010036790 Productive cough Diseases 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 6
- 239000010839 body fluid Substances 0.000 description 6
- 208000013116 chronic cough Diseases 0.000 description 6
- 230000007812 deficiency Effects 0.000 description 6
- 230000003203 everyday effect Effects 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 210000003026 hypopharynx Anatomy 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 208000011580 syndromic disease Diseases 0.000 description 6
- 208000006820 Arthralgia Diseases 0.000 description 5
- 206010007247 Carbuncle Diseases 0.000 description 5
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 5
- 206010010774 Constipation Diseases 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 5
- 206010020565 Hyperaemia Diseases 0.000 description 5
- 108090001005 Interleukin-6 Proteins 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- 208000025865 Ulcer Diseases 0.000 description 5
- 208000038016 acute inflammation Diseases 0.000 description 5
- 230000006022 acute inflammation Effects 0.000 description 5
- 230000036760 body temperature Effects 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 244000052769 pathogen Species 0.000 description 5
- 239000002574 poison Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 231100000397 ulcer Toxicity 0.000 description 5
- 210000002396 uvula Anatomy 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 208000000059 Dyspnea Diseases 0.000 description 4
- 206010013975 Dyspnoeas Diseases 0.000 description 4
- 235000009161 Espostoa lanata Nutrition 0.000 description 4
- 240000001624 Espostoa lanata Species 0.000 description 4
- 206010023126 Jaundice Diseases 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 4
- 230000003750 conditioning effect Effects 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 210000003608 fece Anatomy 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 210000000232 gallbladder Anatomy 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- 230000008595 infiltration Effects 0.000 description 4
- 238000001764 infiltration Methods 0.000 description 4
- 230000001047 pyretic effect Effects 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- 208000019505 Deglutition disease Diseases 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 208000015220 Febrile disease Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 208000005392 Spasm Diseases 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 230000000954 anitussive effect Effects 0.000 description 3
- 230000000840 anti-viral effect Effects 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 238000011888 autopsy Methods 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 208000002173 dizziness Diseases 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 208000035861 hematochezia Diseases 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 238000010926 purge Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 210000003802 sputum Anatomy 0.000 description 3
- 208000024794 sputum Diseases 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 230000008736 traumatic injury Effects 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- CRDNMYFJWFXOCH-YPKPFQOOSA-N (3z)-3-(3-oxo-1h-indol-2-ylidene)-1h-indol-2-one Chemical compound N/1C2=CC=CC=C2C(=O)C\1=C1/C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-YPKPFQOOSA-N 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 206010010726 Conjunctival oedema Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 206010013952 Dysphonia Diseases 0.000 description 2
- 208000034507 Haematemesis Diseases 0.000 description 2
- 208000000616 Hemoptysis Diseases 0.000 description 2
- 208000010473 Hoarseness Diseases 0.000 description 2
- 206010020880 Hypertrophy Diseases 0.000 description 2
- 201000005505 Measles Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 206010062575 Muscle contracture Diseases 0.000 description 2
- 206010028851 Necrosis Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010057190 Respiratory tract infections Diseases 0.000 description 2
- 208000025747 Rheumatic disease Diseases 0.000 description 2
- 208000033809 Suppuration Diseases 0.000 description 2
- 206010043458 Thirst Diseases 0.000 description 2
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 210000002534 adenoid Anatomy 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 230000004856 capillary permeability Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 208000019902 chronic diarrheal disease Diseases 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 208000006111 contracture Diseases 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 230000013872 defecation Effects 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 208000017574 dry cough Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- 230000037308 hair color Effects 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 208000006750 hematuria Diseases 0.000 description 2
- 210000003494 hepatocyte Anatomy 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000009438 liyan Substances 0.000 description 2
- 201000003453 lung abscess Diseases 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 210000003516 pericardium Anatomy 0.000 description 2
- 229940023488 pill Drugs 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 230000000552 rheumatic effect Effects 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009747 swallowing Effects 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 241000321096 Adenoides Species 0.000 description 1
- 206010002953 Aphonia Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 208000010445 Chilblains Diseases 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- CRDNMYFJWFXOCH-BUHFOSPRSA-N Couroupitine B Natural products N\1C2=CC=CC=C2C(=O)C/1=C1/C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-BUHFOSPRSA-N 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 241000234273 Dioscorea Species 0.000 description 1
- 235000005903 Dioscorea Nutrition 0.000 description 1
- 235000000504 Dioscorea villosa Nutrition 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 206010064503 Excessive skin Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010054787 Haemorrhoidal haemorrhage Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 206010028116 Mucosal inflammation Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 206010039587 Scarlet Fever Diseases 0.000 description 1
- 208000008630 Sialorrhea Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 241000219784 Sophora Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 206010048245 Yellow skin Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 206010001093 acute tonsillitis Diseases 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000001355 anti-mycobacterial effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 210000003123 bronchiole Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 235000019994 cava Nutrition 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 235000004879 dioscorea Nutrition 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 210000001174 endocardium Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 229940100601 interleukin-6 Drugs 0.000 description 1
- 108010088383 interleukin-6 receptor alpha Proteins 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- CRDNMYFJWFXOCH-UHFFFAOYSA-N isoindigotin Natural products N1C2=CC=CC=C2C(=O)C1=C1C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-UHFFFAOYSA-N 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 201000002266 mite infestation Diseases 0.000 description 1
- 210000002464 muscle smooth vascular Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 229960005224 roxithromycin Drugs 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for curing acute pharyngitis. Bulk drugs of the traditional Chinese medicine composition include herb of glabrous sarcandra, polygonum cuspidatum, rhizoma acori graminei, Chinese mahonia stems, scaphium scaphigerum, scutellaria baicalensis, periostracum cicada, dioscorea panthaica prain et burk, radix asteris, flos sophorae, gallnut, fructus gleditsiae, solidago virgaurea, indigo naturalis, ephedra, rhizoma panacis majoris, radix polygonati officinalis, sea-buckthorn, myrobalan, radix scrophulariae, kadsura pepper stems, panax japonicus, puffball, adenophora tetraphylla, Chinese yam, wadalee-gum-tree and liquorice. The traditional Chinese medicine composition can not only control the symptom of acute pharyngitis, but also adjust the equilibrium between yin and yang, improve immunity of human bodies to improve the purposes of nourishing, nursing, relieving symptom, protecting and solidifying the body, and has the advantages of no toxic and side effect, no drug resistance, good curative effect, quickness of becoming effective, no damage to human bodies, and no recurrence of illness after treatment compared with the western medicine for curing acute pharyngitis.
Description
Technical field
The present invention relates to Chinese medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of acute pharyngitis and preparation method thereof.
Background technology
Pharynx is one of organ of wanting of body weight for humans, is human body and the extraneous thoroughfare communicating.When throat is subject to antibacterial and viral infection, just easily causes upper respiratory tract infection and infect.Pharyngitis is that the pharyngeal mucosa that caused by upper respiratory tract infection and the inflammation of submucous tissue thereof are assembled.Pharyngitis can be divided into according to the length of the course of disease and the difference of pathomorphology character: acute pharyngitis and chronic pharyngitis.
Acute pharyngitis (acute pharyngitis): be pharyngeal mucosa, submucous tissue and adenoid acute inflammation thereof, it is a part for clinical common upper respiratory tract actute infection, be commonly encountered diseases, the frequently-occurring disease of hals,Nasen und Ohrenheilkunde, sickness rate is high, accounts for otorhinolaryngologic 2%～6%, 7%～17% of Zhan Hou section, complication is many, can cause measles, influenza, scarlet fever etc., can occur separately, also can be caused by acute rhinitis or acute tonsillitis, mostly occur in the replacement of autumn and winter or Winter-Spring.Acute pharyngitis is often because of flu, and overfatigue, is subject to the stimulations such as chemical gas, dust for a long time, or because of impacts such as sinusitis, Abwehrkraft des Koepers reduces, and it is pathogenic that antibacterial or virus are taken advantage of a weak point, if the prolonged and repeated outbreak of acute pharyngitis, the chronic pharyngitis that can cause being difficult to healing.
The pathological change that acute pharyngitis can cause, not only can cause pharyngeal pathological changes, also can involve other contiguous organs, it is involved, even affect other functions of body, present stage has more and more had influence on the mankind's health status and work normally, has lived.
Modern medicine mostly adopts antibiotics or is aided with the hormones preparations such as dexamethasone, and antiviral drugs, treatment acute pharyngitis.But treatment spectrum is narrow, easily outbreak repeatedly, toleration are poor, large, the common pathogenic microorganism of toxic and side effects reaction produces drug resistance, drug combination to medicine mutual cross action easily occurs, and affects the health giving quality of patient dependence and medicine.
Compared with modern medicine, it is little that the traditional Chinese medical science has toxic and side effects in treatment aspect disease, and effect is lasting, and the features such as treating both the principal and secondary aspects of a disease have a large amount of experiences aspect treatment acute pharyngitis.Acute pharyngitis belongs to " acute inflammation of the throat " category in motherland's medical science, and how because of wind-heat evil toxin invasion and attack throat, internal injury, in lung, is fought and do not gone mutually, causes swelling throat plug and arthralgia pain; Or pathogenic heat heap soil or fertilizer over and around the roots Sheng, by lung, to be defended in biography, pathogenic heat is followed through the throat of burning, make laryngopharynx swelling and pain form sore throat, primary disease is to have sore throat, red swelling of the pharynx, at the bottom of larynx or have granule projection, pharyngeal tonsils swelling is not obvious, and it is the pharyngeal acute inflammation of main clinical manifestation that whole body has wind heat symptom.
Traditional chinese medicine medicament treatment acute pharyngitis, take treating both the principal and secondary aspects of a disease as principle, not only can be controlled the surface symptoms of acute pharyngitis, can also regulate equilibrium between yin and yang, strengthens body immunity, reaches nourishing, conditioning, relief of symptoms, holds up this solid positive object.
The present invention is exactly take theory of Chinese medical science as basis, proposes a kind of Chinese medicine composition that is used for the treatment of acute pharyngitis, not only can control the symptom of acute pharyngitis, can also regulate equilibrium between yin and yang, strengthen body immunity, reach nourishing, conditioning, relief of symptoms, hold up this solid positive object, with respect to western medicine acute pharyngitis, this Chinese medicine composition has no side effect, have no drug resistance, good effect, instant effect, to human zero damage, after treatment, the state of an illness is not repeatedly.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine composition that is used for the treatment of acute pharyngitis is provided, and not only can control the symptom of acute pharyngitis, can also regulate equilibrium between yin and yang, strengthen body immunity, reach nourishing, conditioning, relief of symptoms, hold up this solid positive object, with respect to western medicine acute pharyngitis, this Chinese medicine composition has no side effect, have no drug resistance, good effect, instant effect, to human zero damage, after treatment, the state of an illness is not repeatedly.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of acute pharyngitis, its crude drug comprises: Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Sarcandrae 42 weight portion ~ 52 weight portions, Rhizoma Polygoni Cuspidati 46 weight portion ~ 56 weight portions, Rhizoma Acori Graminei 23 weight portion ~ 33 weight portions, Caulis Mahoniae 34 weight portion ~ 44 weight portions, Semen Sterculiae Lychnophorae 29 weight portion ~ 39 weight portions, Radix Scutellariae 77 weight portion ~ 87 weight portions, Periostracum Cicadae 16 weight portion ~ 26 weight portions, Dioscorea panthaica Prain et Burkill 42 weight portion ~ 52 weight portions, Radix Asteris 26 weight portion ~ 36 weight portions, Flos Sophorae 13 weight portion ~ 23 weight portions, Galla Chinensis 39 weight portion ~ 49 weight portions, Fructus Gleditsiae Abnormalis 22 weight portion ~ 32 weight portions, Herba Solidaginis 25 weight portion ~ 35 weight portions, Indigo Naturalis 61 weight portion ~ 71 weight portions, Herba Ephedrae 30 weight portion ~ 40 weight portions, Rhizoma Panacis Majoris 39 weight portion ~ 49 weight portions, Rhizoma Polygonati Odorati 18 weight portion ~ 28 weight portions, Fructus Hippophae 26 weight portion ~ 36 weight portions, Fructus Chebulae's 20 weight portion ~ 30 weight portions, Radix Scrophulariae 27 weight portion ~ 37 weight portions, Caulis Piperis Kadsurae 35 weight portion ~ 45 weight portions, Rhizoma Panacis Japonici 30 weight portion ~ 40 weight portions, Lasiosphaera Seu Calvatia 16 weight portion ~ 26 weight portions, Radix Adenophorae 31 weight portion ~ 41 weight portions, Rhizoma Dioscoreae 39 weight portion ~ 49 weight portions, catechu 19 weight portion ~ 29 weight portions and Radix Glycyrrhizae 26 weight portion ~ 36 weight portions.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Sarcandrae 45 weight portion ~ 49 weight portions, Rhizoma Polygoni Cuspidati 49 weight portion ~ 53 weight portions, Rhizoma Acori Graminei 26 weight portion ~ 30 weight portions, Caulis Mahoniae 37 weight portion ~ 41 weight portions, Semen Sterculiae Lychnophorae 32 weight portion ~ 36 weight portions, Radix Scutellariae 80 weight portion ~ 84 weight portions, Periostracum Cicadae 19 weight portion ~ 23 weight portions, Dioscorea panthaica Prain et Burkill 45 weight portion ~ 49 weight portions, Radix Asteris 29 weight portion ~ 33 weight portions, Flos Sophorae 16 weight portion ~ 20 weight portions, Galla Chinensis 42 weight portion ~ 46 weight portions, Fructus Gleditsiae Abnormalis 25 weight portion ~ 29 weight portions, Herba Solidaginis 28 weight portion ~ 32 weight portions, Indigo Naturalis 64 weight portion ~ 68 weight portions, Herba Ephedrae 33 weight portion ~ 37 weight portions, Rhizoma Panacis Majoris 42 weight portion ~ 46 weight portions, Rhizoma Polygonati Odorati 21 weight portion ~ 25 weight portions, Fructus Hippophae 29 weight portion ~ 33 weight portions, Fructus Chebulae's 23 weight portion ~ 27 weight portions, Radix Scrophulariae 30 weight portion ~ 34 weight portions, Caulis Piperis Kadsurae 38 weight portion ~ 42 weight portions, Rhizoma Panacis Japonici 33 weight portion ~ 37 weight portions, Lasiosphaera Seu Calvatia 19 weight portion ~ 23 weight portions, Radix Adenophorae 34 weight portion ~ 38 weight portions, Rhizoma Dioscoreae 42 weight portion ~ 46 weight portions, catechu 22 weight portion ~ 26 weight portions and Radix Glycyrrhizae 29 weight portion ~ 33 weight portions.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Sarcandrae 47 weight portions, Rhizoma Polygoni Cuspidati 51 weight portions, Rhizoma Acori Graminei 28 weight portions, Caulis Mahoniae 39 weight portions, Semen Sterculiae Lychnophorae 34 weight portions, Radix Scutellariae 82 weight portions, Periostracum Cicadae 21 weight portions, Dioscorea panthaica Prain et Burkill 47 weight portions, Radix Asteris 31 weight portions, Flos Sophorae 18 weight portions, Galla Chinensis 44 weight portions, Fructus Gleditsiae Abnormalis 27 weight portions, Herba Solidaginis 30 weight portions, Indigo Naturalis 66 weight portions, Herba Ephedrae 35 weight portions, Rhizoma Panacis Majoris 44 weight portions, Rhizoma Polygonati Odorati 23 weight portions, Fructus Hippophae 31 weight portions, Fructus Chebulae's 25 weight portions, Radix Scrophulariae 32 weight portions, Caulis Piperis Kadsurae 40 weight portions, Rhizoma Panacis Japonici 35 weight portions, Lasiosphaera Seu Calvatia 21 weight portions, Radix Adenophorae 36 weight portions, Rhizoma Dioscoreae 44 weight portions, catechu 24 weight portions and Radix Glycyrrhizae 31 weight portions.
Wherein, the dosage form of described Chinese medicine composition is tablet, soft capsule, powder, granule, pill, mixture.
The present invention also provides the application of above-mentioned Chinese medicine composition in the medicine for the preparation for the treatment of acute pharyngitis.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is granule, is specially:
The first step, described each crude drug component is sent in mixing and blending machine and is uniformly mixed, then pour in multi-function extractor, add with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums and decoct 2 ~ 3 hours, in decoction process, control steam pressure at 0.05 ~ 0.1Mpa, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums and decoct 2 ~ 3 hours, in decoction process, control steam pressure at 0.05 ~ 0.1Mpa, temperature is controlled at 98 ~ 102 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution,
Second step, with hydrochloric acid, regulating the pH value of total extracting solution is 5 ~ 6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin be 2 ~ 3:1, and first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 5 ~ 7 times of the quality of macroporous adsorbent resin be 60% ~ 80%, collect eluent, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, be ground into fine powder, spraying is dry;
The 3rd step adds corn dextrin and cane sugar powder in dried fine powder, mixes, granulate, splitting and filling, with respect to the dried cream powder of 100 weight portions, the addition of corn dextrin is 80 weight portion ~ 120 weight portions, and the addition of cane sugar powder is 300 weight portion ~ 400 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is tablet, is specially:
The first step, described each crude drug component is sent in mixing and blending machine and is uniformly mixed, then pour in multi-function extractor, add with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums and decoct 2 ~ 3 hours, in decoction process, control steam pressure at 0.05 ~ 0.1Mpa, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums and decoct 2 ~ 3 hours, in decoction process, control steam pressure at 0.05 ~ 0.1Mpa, temperature is controlled at 98 ~ 102 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution,
Second step, with hydrochloric acid, regulating the pH value of total extracting solution is 5 ~ 6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin be 2 ~ 3:1, and first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 5 ~ 7 times of the quality of macroporous adsorbent resin be 60% ~ 80%, collect eluent, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, be ground into fine powder, spraying is dry;
The 3rd step, after the microcrystalline Cellulose of the sodium carboxymethyl cellulose of the polyvinylpyrrolidone of dry spraying fine powder 100 weight portions that obtain and 60～100 weight portions, 30～50 weight portions, 120～180 weight portions is mixed, with the determining alcohol of 20～30 weight portions, be that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 45 ℃～50 ℃ temperature ranges, with 16 mesh sieve granulate, and add after the magnesium stearate of 7～9 weight portions and the micropowder silica gel of 6～8 weight portions, material is pressed into medicinal dispersing tablets.
The present invention also provides a kind of Chinese medicinal composition granules that is used for the treatment of acute pharyngitis, its crude drug comprises: Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae
The preparation method of described granule is specially,
The first step, described each crude drug component is sent in mixing and blending machine and is uniformly mixed, then pour in multi-function extractor, add with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums and decoct 2 ~ 3 hours, in decoction process, control steam pressure at 0.05 ~ 0.1Mpa, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums and decoct 2 ~ 3 hours, in decoction process, control steam pressure at 0.05 ~ 0.1Mpa, temperature is controlled at 98 ~ 102 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution,
Second step, with hydrochloric acid, regulating the pH value of total extracting solution is 5 ~ 6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin be 2 ~ 3:1, and first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 5 ~ 7 times of the quality of macroporous adsorbent resin be 60% ~ 80%, collect eluent, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, be ground into fine powder, spraying is dry;
The 3rd step adds corn dextrin and cane sugar powder in dried fine powder, mixes, granulate, splitting and filling, with respect to the dried cream powder of 100 weight portions, the addition of corn dextrin is 80 weight portion ~ 120 weight portions, and the addition of cane sugar powder is 300 weight portion ~ 400 weight portions.
The present invention also provides a kind of Chinese medicine composition tablet that is used for the treatment of acute pharyngitis, its crude drug comprises: Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae
The preparation method of described tablet is specially,
The first step, described each crude drug component is sent in mixing and blending machine and is uniformly mixed, then pour in multi-function extractor, add with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums and decoct 2 ~ 3 hours, in decoction process, control steam pressure at 0.05 ~ 0.1Mpa, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums and decoct 2 ~ 3 hours, in decoction process, control steam pressure at 0.05 ~ 0.1Mpa, temperature is controlled at 98 ~ 102 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution,
Second step, with hydrochloric acid, regulating the pH value of total extracting solution is 5 ~ 6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin be 2 ~ 3:1, and first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 5 ~ 7 times of the quality of macroporous adsorbent resin be 60% ~ 80%, collect eluent, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, be ground into fine powder, spraying is dry;
The 3rd step, after the microcrystalline Cellulose of the sodium carboxymethyl cellulose of the polyvinylpyrrolidone of dry spraying fine powder 100 weight portions that obtain and 60～100 weight portions, 30～50 weight portions, 120～180 weight portions is mixed, with the determining alcohol of 20～30 weight portions, be that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 45 ℃～50 ℃ temperature ranges, with 16 mesh sieve granulate, and add after the magnesium stearate of 7～9 weight portions and the micropowder silica gel of 6～8 weight portions, material is pressed into medicinal dispersing tablets.
Beneficial effect of the present invention:
The Chinese medicine composition that is used for the treatment of acute pharyngitis provided by the invention, not only can control the symptom of acute pharyngitis, can also regulate equilibrium between yin and yang, strengthen body immunity, reach nourishing, conditioning, relief of symptoms, hold up this solid positive order, with respect to western medicine acute pharyngitis, this Chinese medicine composition has no side effect, and has no drug resistance, good effect, instant effect, to human zero damage, after treatment, the state of an illness is not repeatedly.
The specific embodiment
Acute pharyngitis belongs to the traditional Chinese medical science " acute inflammation of the throat " category, because exopathogen visitor is due to pharyngeal, the heresy of the not outer wind and cold of exopathogen and wind heat, and the easily strongly fragrant and heat-transformation of the heresy of wind and cold, therefore clinical common with wind-heat syndrome, therefore be called again " acute pharyngitis due to wind-heat ", motherland's medical science has again saying of " throat disease all belonging to fire ", and its sick position is at pharynx and lung.In close relations with stomach, the cause of disease is main mainly with " wind heat poison ", and heat syndrome is in the majority, and cold person is little, and the strongly fragrant and factors such as heat-transformation of wind-cold tightening the lung.Acute pharyngitis mostly is the heresy of experiencing wind heat, lung defend lose solid, exopathogen in throat with the QI and blood knot of fighting mutually, or wind-cold affecting lung, exopathogen is not understood, the strongly fragrant and heat-transformation of cold-evil, tie in throat, or exuberant lung-stomach heat, on steam in throat and occur pharyngalgia, silent, dysphagia, red swelling of the pharynx, dryness and heat sense or itch and cough, or cough expectorant Huang, heating, constipation with dry stool, yellow urine, red tongue, yellow and greasy fur, full and rapid pulse etc.
< < Plain Questions negative and positive another matter piece of writing > > cloud " monoyin and monoyang knot; the sore throat of meaning ", and former sick formula six gas of < < Plain Questions arcane truth to be the fiery class sore throat of disease > > be interpreted as: " sore throat; numbness; also meciless; custom is closed, still obturation is also ".Be that primary disease is because interior exopathogen poison knot is poly-, and cause qi depression to blood stasis, due to BI-syndrome involved the blood vessels resistance, burning hot heresy can be accelerated again the operation of blood simultaneously, and the venation of burning is overflow hot forcing blood, and blood is from through forming the stasis of blood, therefore " stasis of blood " the individual main pathogenesis that is one.As far back as < < Medical Treasures of the Golden Chamber > >, say: " heat is mistake for it; stagnation of blood ", < < Shengji Zonglu typhoid fever system opinion > > also has the opinion of " in poison is evil, the stasis of blood becomes blood stasis ".According to the further investigation of modern blood stasis symptom, recognize that in acute inflammation of the throat, existing local infection body tissue dissolves (suppuration), capillary permeability strengthens, Local residues Denatured protein, the pathogenesis of blood stasis such as tissue fibering, pass through blood circulation promoting and blood stasis dispelling in treatment, accelerate velocity of blood flow and eliminate stasis of blood stream, improve the blood circulation of local organization, promote the absorption of inflammatory exudate, alleviate or eliminate the symptoms such as pharyngeal congestion, edema.
According to above-mentioned theory of Chinese medical science, the present invention is take wind and heat dispersing, lung qi dispersing sore-throat relieving, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting as Therapeutic Principle, a kind of oral traditional Chinese medicine composition that is used for the treatment of acute pharyngitis is provided, and it comprises following crude drug: Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae.
Preferably, described oral traditional Chinese medicine composition only consists of above-mentioned raw materials medicine.
In side, Herba Sarcandrae, Dioscorea panthaica Prain et Burkill heat-clearing and toxic substances removing, anti-inflammation detumescence, the clear eliminating the pathogens from the lung heat of Rhizoma Polygoni Cuspidati, expelling phlegm for arresting cough, dissipating blood stasis analgesic therapy, Rhizoma Acori Graminei is had one's ideas straightened out loose evil, clearing away heat to alleviate pain, expelling pathogenic factors from the exterior is gone out with sore-throat relieving, Caulis Mahoniae, Indigo Naturalis has anticoagulant, improves immunity of organism, protect the liver, function of gallbladder promoting, promotes the effect of bile secretion, under Semen Sterculiae Lychnophorae rushes down, blood pressure lowering, diuresis, analgesia, has contraction to vascular smooth muscle, can improve mucosal inflammation and alleviate spasmic pain, Periostracum Cicadae relieving sore throat to recover voice, Radix Asteris nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm, heat clearing away sophora pathogenic fire purging, eliminating stagnation throat, expelling pathogenic factors from the exterior is gone out, and is applicable to the card of laryngopharynx swelling and pain due to the evil poison of diseases caused by exogenous pathogenic factor, and Fructus Gleditsiae Abnormalis is to position, oral cavity, the direct stimulation of gastric mucosa, reflexive ground increases bronchial mucosa hypersecretion, thereby makes sputum dilution, is easy to discharge and an antitussive effect Herba Solidaginis, Indigo Naturalis, Rhizoma Polygoni Cuspidati, Radix Scutellariae has the various pathogens such as anti-mycobacterium tuberculosis and all has certain inhibitory action, to Multiple Classes of Antibiotics, can make inflammation local vascular shrink, and alleviates its inflammatory reaction, Herba Ephedrae lung qi dispersing table and relievining asthma, and cough-relieving sea-buckthorn eliminates the phlegm, promoting blood circulation to remove blood stasis, Fructus Chebulae's sore-throat relieving clearing away lung-heat to relieve cough, Radix Scrophulariae nourishing YIN to lower pathogenic fire, clearing away heat and cooling blood, eliminating stagnation sore-throat relieving, Caulis Piperis Kadsurae expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, the loose blood of the clear part of the body cavity above the diaphragm housing the heart and lungs lung-heat of Lasiosphaera Seu Calvatia and liyan jiedu, Rhizoma Panacis Japonici expelling phlegm for arresting cough, dissipating blood stasis for subsidence of swelling, Radix Adenophorae replenishing YIN and removing heat, moistening the lung and resolving phlegm, Rhizoma Polygonati Odorati nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the yin nourishing of Rhizoma Panacis Majoris tonifying the lung, dissipating blood stasis hemostasis, the Galla Chinensis pathogenic fire reducing of astringing the lung, removing toxic substances sore, catechu removing toxic substances and promoting granulation, dehumidifying dysentery relieving, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, each crude drug is combined use, realizes wind and heat dispersing, lung qi dispersing sore-throat relieving, blood circulation promoting and blood stasis dispelling, the effect of putrefaction-removing granulation-promoting.
Pharmacological research shows; Chinese medicine composition provided by the invention all has stronger anti-microbial property to the blue coccus of most leather, bacillus; can reduce capillary permeability; there are the effects such as certain functions of detumescence, relieving inflammation, antiviral, analgesia, the recovery of promotion mucosal epithelium; can protect or improve body's immunity, thereby can strengthen the effect of leading pyretic toxicity, detumescence switching off, can eliminate rapidly pharyngeal swelling and ache; reach pharyngeal mucosa reparation, the object of rehabilitation.
In described Chinese medicine composition, each raw material medicines in portions by weight is respectively:
Herba Sarcandrae 42 weight portion ~ 52 weight portions, Rhizoma Polygoni Cuspidati 46 weight portion ~ 56 weight portions, Rhizoma Acori Graminei 23 weight portion ~ 33 weight portions, Caulis Mahoniae 34 weight portion ~ 44 weight portions, Semen Sterculiae Lychnophorae 29 weight portion ~ 39 weight portions, Radix Scutellariae 77 weight portion ~ 87 weight portions, Periostracum Cicadae 16 weight portion ~ 26 weight portions, Dioscorea panthaica Prain et Burkill 42 weight portion ~ 52 weight portions, Radix Asteris 26 weight portion ~ 36 weight portions, Flos Sophorae 13 weight portion ~ 23 weight portions, Galla Chinensis 39 weight portion ~ 49 weight portions, Fructus Gleditsiae Abnormalis 22 weight portion ~ 32 weight portions, Herba Solidaginis 25 weight portion ~ 35 weight portions, Indigo Naturalis 61 weight portion ~ 71 weight portions, Herba Ephedrae 30 weight portion ~ 40 weight portions, Rhizoma Panacis Majoris 39 weight portion ~ 49 weight portions, Rhizoma Polygonati Odorati 18 weight portion ~ 28 weight portions, Fructus Hippophae 26 weight portion ~ 36 weight portions, Fructus Chebulae's 20 weight portion ~ 30 weight portions, Radix Scrophulariae 27 weight portion ~ 37 weight portions, Caulis Piperis Kadsurae 35 weight portion ~ 45 weight portions, Rhizoma Panacis Japonici 30 weight portion ~ 40 weight portions, Lasiosphaera Seu Calvatia 16 weight portion ~ 26 weight portions, Radix Adenophorae 31 weight portion ~ 41 weight portions, Rhizoma Dioscoreae 39 weight portion ~ 49 weight portions, catechu 19 weight portion ~ 29 weight portions and Radix Glycyrrhizae 26 weight portion ~ 36 weight portions.
In described Chinese medicine composition, the weight portion of each crude drug is further preferably respectively:
Herba Sarcandrae 45 weight portion ~ 49 weight portions, Rhizoma Polygoni Cuspidati 49 weight portion ~ 53 weight portions, Rhizoma Acori Graminei 26 weight portion ~ 30 weight portions, Caulis Mahoniae 37 weight portion ~ 41 weight portions, Semen Sterculiae Lychnophorae 32 weight portion ~ 36 weight portions, Radix Scutellariae 80 weight portion ~ 84 weight portions, Periostracum Cicadae 19 weight portion ~ 23 weight portions, Dioscorea panthaica Prain et Burkill 45 weight portion ~ 49 weight portions, Radix Asteris 29 weight portion ~ 33 weight portions, Flos Sophorae 16 weight portion ~ 20 weight portions, Galla Chinensis 42 weight portion ~ 46 weight portions, Fructus Gleditsiae Abnormalis 25 weight portion ~ 29 weight portions, Herba Solidaginis 28 weight portion ~ 32 weight portions, Indigo Naturalis 64 weight portion ~ 68 weight portions, Herba Ephedrae 33 weight portion ~ 37 weight portions, Rhizoma Panacis Majoris 42 weight portion ~ 46 weight portions, Rhizoma Polygonati Odorati 21 weight portion ~ 25 weight portions, Fructus Hippophae 29 weight portion ~ 33 weight portions, Fructus Chebulae's 23 weight portion ~ 27 weight portions, Radix Scrophulariae 30 weight portion ~ 34 weight portions, Caulis Piperis Kadsurae 38 weight portion ~ 42 weight portions, Rhizoma Panacis Japonici 33 weight portion ~ 37 weight portions, Lasiosphaera Seu Calvatia 19 weight portion ~ 23 weight portions, Radix Adenophorae 34 weight portion ~ 38 weight portions, Rhizoma Dioscoreae 42 weight portion ~ 46 weight portions, catechu 22 weight portion ~ 26 weight portions and Radix Glycyrrhizae 29 weight portion ~ 33 weight portions.
In described Chinese medicine composition, the weight portion of each crude drug is most preferably respectively:
Herba Sarcandrae 47 weight portions, Rhizoma Polygoni Cuspidati 51 weight portions, Rhizoma Acori Graminei 28 weight portions, Caulis Mahoniae 39 weight portions, Semen Sterculiae Lychnophorae 34 weight portions, Radix Scutellariae 82 weight portions, Periostracum Cicadae 21 weight portions, Dioscorea panthaica Prain et Burkill 47 weight portions, Radix Asteris 31 weight portions, Flos Sophorae 18 weight portions, Galla Chinensis 44 weight portions, Fructus Gleditsiae Abnormalis 27 weight portions, Herba Solidaginis 30 weight portions, Indigo Naturalis 66 weight portions, Herba Ephedrae 35 weight portions, Rhizoma Panacis Majoris 44 weight portions, Rhizoma Polygonati Odorati 23 weight portions, Fructus Hippophae 31 weight portions, Fructus Chebulae's 25 weight portions, Radix Scrophulariae 32 weight portions, Caulis Piperis Kadsurae 40 weight portions, Rhizoma Panacis Japonici 35 weight portions, Lasiosphaera Seu Calvatia 21 weight portions, Radix Adenophorae 36 weight portions, Rhizoma Dioscoreae 44 weight portions, catechu 24 weight portions and Radix Glycyrrhizae 31 weight portions.
The pharmacology of each crude drug is as follows:
Herba Sarcandrae: latin name Sarcandrae Herba, slightly warm in nature, bitter in the mouth, pungent, has anti-inflammation, dispelling wind and removing obstruction in the collateral, the effect of blood circulation promoting and dispersing pathogen accumulation, cures mainly the cards such as pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor.
Rhizoma Polygoni Cuspidati: latin name Polygoni Cuspidati Rhizoma etRadix, micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian, there is heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, the effect of relieving cough and resolving phlegm, for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, the cards such as carbuncle sore tumefacting virus.
Rhizoma Acori Graminei: acrid in the mouth, warm in nature, enter the heart, stomach warp, has the refreshment of having one's ideas straightened out, and the effect of removing dampness to restore normal function of the stomach is used for the treatment of expectorant and covers clear key, and coma is demented, dizziness, insomnia, forgetful, tinnitus, retention of dampness in middle-JIAO, the cards such as abdominal distention.
Caulis Mahoniae: bitter in the mouth, cold in nature, return large intestine, kidney, lung meridian, there is the effect of heat clearing away, dampness, removing toxic substances, cure mainly cough due to lung-heat, jaundice, has loose bowels, dysentery, conjunctival congestion and swelling pain, skin infection, eczema, the cards such as scald.
Semen Sterculiae Lychnophorae: sweet in the mouth, light, cool in nature, return lung, large intestine channel, there are clearing heat and moistening lung, liyan jiedu, the effect of loosening bowel to relieve constipation, cures mainly lung-heat celostomia, dry cough without phlegm, pharyngodynia with dryness, accumulation of heat just closes, the effect of headache conjunctival congestion.
Radix Scutellariae: latin name Scutellariae Radix, bitter in the mouth, cold in nature, enters the heart, lung, stomach, gallbladder, large intestine channel, has heat clearing and damp drying, and eliminating fire and detoxication is antiabortive, and the effect of hemostasis is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; Cough due to lung-heat, thirsty pharyngalgia, also can be used for excessive fetal movement due to heat in pregnancy, and pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.
Periostracum Cicadae: latin name Cicadae Periostracum, sweet in the mouth, lung, the Liver Channel of returning cold in nature, there is a surname's wind heat extraction, rash, sore-throat relieving, the effect of spasmolytic, cure mainly affection due to external wind and heat or epidemic febrile disease from the beginning of due to heating, cough, pharyngalgia, pharynx mute, measles is thoroughly sent out not smooth, rubella pruritus, wind-heat of liver channel, the cards such as the many tears of conjunctival congestion.
Dioscorea panthaica Prain et Burkill: latin name Dioscorea Panthaicae Rhizoma, sweet in the mouth, micro-pungent, property is flat, returns stomach, heart channel, has regulating QI to relieve pain, and the effect of removing toxic substances and promoting subsidence of swelling cures mainly stomachache, vomits and diarrhoea and suffer from abdominal pain, traumatic injury, the cards such as tuberculous lymphadenitis are controlled in external.
Radix Asteris: bitter in the mouth, sweet, slightly warm in nature, enters lung meridian, have dredging lung meridian QI and blood, nourishing the lung to keep the adverse QI downward, the effect of relieving cough and resolving phlegm, is mainly used in various cough with dyspnea, the cards such as expectoration is not well, sputum mixed with blood, the cough with dyspnea of especially applicable lung qi stasis, visitor prevents and treats the hemoptysis vomiting pus of lung abscess, exogenous cough, no matter wind and cold wind heat, all applicable, Radix Asteris can increase bronchial secretion, in order to expectoration, and has the effect of antitussive.
Flos Sophorae: bitter in the mouth, cold nature, return liver, large intestine channel, there is cooling blood for hemostasis, the effect of purging liver-fire; Cure mainly discharging fresh blood stool, hemorrhoidal bleeding, dysentery, hematuria, stranguria with blood, metrorrhagia, spits blood, epistaxis, liver-fire headache, conjunctival congestion and swelling pain, sore throat, aphonia, the cards such as ulcer sores.
Galla Chinensis: latin name GallaChinensis, sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, there is the effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; Chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; The cards such as carbuncle furuncle, the defence capability of Galla Chinensis energy enhancing body to nonspecific stimulation, can strengthen the immunologic function of cell, and this pathogenic bacterium are had to inhibitory action, and can antiviral growth.
Fructus Gleditsiae Abnormalis: acrid in the mouth, salty, warm in nature, slightly poisonous, enter lung, stomach, large intestine channel, having eliminates the phlegm has one's ideas straightened out, and the effect of mass dissipating and swelling eliminating cures mainly apoplexy locked mouth, wind syndrome of head, wind is chronic, sore throat, phlegm dyspnea, feeling of fullness is stagnant, and obstruction and rejection is obstructed, carbuncle, mange, tinea disease, head sore.
Herba Solidaginis: latin name Solidaginis Herba, acrid in the mouth, hardship, cool in nature, return lung, Liver Channel, there is the effect of heat-clearing and toxic substances removing, dispelling wind and heat pathogens, cure mainly the cards such as sore throat, laryngopharynx swelling and pain, anemopyretic cold.
Indigo Naturalis: salty in the mouth, cold in nature, enter Liver Channel, there is the effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire, for epidemic febrile disease, send out the cards such as all cards of pyretic toxicity such as speckle, haematemesis, laryngopharynx swelling and pain, herpes eczema, liver-fire invading the lung, cough chest pain, sputum mixed with blood, high hot infantile convulsion, convulsion with spasms, Indigo Naturalis, containing indigo, indirubin, has heat-clearing and toxic substances removing, the antiviral effect of sore, inhibited to cholera bacilli, Bacillus typhi, dysentery bacterium and part virus.
Herba Ephedrae: acrid in the mouth, micro-hardship, warm in nature, enter lung, urinary bladder channel, have and send out cold inducing sweat, depressed lung-energy dispersing, the effect of inducing diuresis to remove edema, is mainly used in the exterior excess syndrome such as fever without perspiration of affection of exogenous wind-cold; Rheumatic arthralgia pain; Pathogenic cold attacking the lung or accumulation of heat in the lung are to cough with asthma QI rising in reverse order, edema, the cards such as dysuria.
Rhizoma Panacis Majoris: bitter in the mouth, sweet, cold nature, enters liver, lung, stomach warp, there is tonifying the lung yin nourishing, dissipating blood stasis hemostasis, the effect of reducing swelling and alleviating pain,, cough due to consumptive disease thirsty for deficiency of both QI and YIN, excessive thirst, various hemorrhages, as haematemesis, hemoptysis, have blood in stool, hematuria, metrorrhagia, traumatic injury wound is swollen, rheumatic arthritis, stomachache, acute toothache, laryngopharynx swelling and pain, the cards such as sore and toxic.
Rhizoma Polygonati Odorati: latin name Polygonati OdoratiRhizoma, sweet in the mouth, property is flat, attaches to the lung and stomach meridians, and has the effect of nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, cures mainly cough caused by dryness; Chronic cough; The dry throat and mouth of the cloudy liquid consumption of calentura wound; Interior-heat is quenched one's thirst; Deficiency of YIN diseases caused by exogenous pathogenic factor; Dizzy dizzy; The cards such as muscle arteries and veins spasm and pain.
Fructus Hippophae: latin name HippophaeFructus, sour in the mouth; Puckery; Warm in nature, there is relieving cough and resolving phlegm; Invigorating the stomach and promoting digestion; The effect of promoting blood circulation to remove blood stasis.Cure mainly cough with copious phlegm; Pulmonary abscess; Dyspepsia; Abdominal pain due to retention of food; Stomachache; Intestinal inflammation; Amenorrhea; The cards such as traumatic injury congestive edema.
Fructus Chebulae: latin name Chebulae Fructus, sour in the mouth, puckery, property is flat, returns lung, and large intestine channel, has relieving diarrhea with astringents, astringing lung-QI and relieving cough, the effect of pathogenic fire reducing sore-throat relieving, for chronic diarrhea chronic dysentery, the proctoptosis of having blood in stool, cough and asthma due to lung deficiency, the card such as chronic cough is more than, pharyngalgia hoarseness.
Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel, there is clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing is supported the effect of kidney, curing mainly pathogenic warmth joins the army, the pericardium that caves in, maculae caused by violent heat pathogen, the cards such as constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.
Caulis Piperis Kadsurae: acrid in the mouth, hardship, slightly warm in nature, returns Liver Channel, has wind-damp dispelling, the meridian dredging, the effect of stopping numbness pain, cures mainly anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, the cards such as joint stuffiness.
Rhizoma Panacis Japonici: latin name Panacis JaponiciRhizoma, sweet in the mouth, micro-hardship, warm in nature, return liver, spleen, lung meridian, there is strengthening by means of tonics, eliminating stasis to stop pain, the effect that hemostasis is eliminated the phlegm, cures mainly weakness after being ill, chronic cough spitting of blood, cough with copious phlegm, the cards such as injury from falling down.
Lasiosphaera Seu Calvatia: acrid in the mouth, property are put down, and enter lung meridian, have moistening lung and nourishing throat, the effect of removing toxic substances hemostasis, for laryngopharynx swelling and pain, lung-heat cough with asthma, pharyngitis, hoarseness, hemorrhage, chilblain, the cards such as decubital ulcer.
Radix Adenophorae: sweet in the mouth, micro-hardship, cold nature, enter lung, stomach warp, have nourishing the lung to arrest cough, the effect of nourishing the stomach to promote the production of body fluid, is mainly used in lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, chronic cough expectorant blood, the cards such as deficiency of stomach-Yin, mouthfeel parched throat, constipation, the few tongue of red tongue, can improve cellular immunization and non-specific immunity, suppress humoral immunization, there is the function that regulates immunologic balance.
Rhizoma Dioscoreae: sweet in the mouth, property are put down, and enter lung, spleen, stomach warp, have spleen reinforcing nourishing the stomach, and lung benefiting reinforces the kidney, and the effect of YIN nourishing and the production of body fluid promoting, cures mainly weakness of the spleen and stomach, the lack of appetite poor appetite of dysfunction of the spleen in transportation, the cards such as the vexed diarrhoea of gastral cavity.
Catechu: bitter in the mouth, puckery, cold nature, returns lung meridian, has the effect of removing dampness promoting tissue regeneration and ulcer healing, for ulcer being unable to heal, eczema, aphtha, falls cards such as flutterring the pain of injury, traumatic hemorrhage.
Radix Glycyrrhizae: sweet in the mouth, property is flat, enters 12 warps, has heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviate the toxic and side effects of medicine to body or gastrointestinal is stimulated, by adding Radix Glycyrrhizae can play QI invigorating neutralization, be in harmonious proportion the effect of each component.
Chinese medicine composition provided by the invention is oral traditional Chinese medicine composition, as required, can be prepared into any regular dosage forms such as tablet, soft capsule, powder, granule, pill, mixture, can be according to the conventional method preparation of each dosage form, preferably, the dosage form of Chinese medicine composition is tablet and granule.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is granule, is specially:
The first step, described each crude drug component is sent in mixing and blending machine and is uniformly mixed, then pour in multi-function extractor, add with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums and decoct 2 ~ 3 hours, in decoction process, control steam pressure at 0.05 ~ 0.1Mpa, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums and decoct 2 ~ 3 hours, in decoction process, control steam pressure at 0.05 ~ 0.1Mpa, temperature is controlled at 98 ~ 102 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution,
Second step, with hydrochloric acid, regulating the pH value of total extracting solution is 5 ~ 6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin be 2 ~ 3:1, and first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 5 ~ 7 times of the quality of macroporous adsorbent resin be 60% ~ 80%, collect eluent, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, be ground into fine powder, spraying is dry;
The 3rd step adds corn dextrin and cane sugar powder in dried fine powder, mixes, granulate, splitting and fill every bag of 10g, with respect to the dried cream powder of 100 weight portions, the addition of corn dextrin is 80 weight portion ~ 120 weight portions, and the addition of cane sugar powder is 300 weight portion ~ 400 weight portions.
The present invention also provides the using method of above-mentioned Chinese medicinal composition granules, and granule is dissolved in warm water, oral, and preferably each 1 bag, each 3 times.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is tablet, is specially:
The first step, described each crude drug component is sent in mixing and blending machine and is uniformly mixed, then pour in multi-function extractor, add with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums and decoct 2 ~ 3 hours, in decoction process, control steam pressure at 0.05 ~ 0.1Mpa, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums and decoct 2 ~ 3 hours, in decoction process, control steam pressure at 0.05 ~ 0.1Mpa, temperature is controlled at 98 ~ 102 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution,
Second step, with hydrochloric acid, regulating the pH value of total extracting solution is 5 ~ 6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin be 2 ~ 3:1, and first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 5 ~ 7 times of the quality of macroporous adsorbent resin be 60% ~ 80%, collect eluent, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, be ground into fine powder, spraying is dry;
The 3rd step, after the microcrystalline Cellulose of the sodium carboxymethyl cellulose of the polyvinylpyrrolidone of dry spraying fine powder 100 weight portions that obtain and 60～100 weight portions, 30～50 weight portions, 120～180 weight portions is mixed, with the determining alcohol of 20～30 weight portions, be that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 45 ℃～50 ℃ temperature ranges, with 16 mesh sieve granulate, and add after the magnesium stearate of 7～9 weight portions and the micropowder silica gel of 6～8 weight portions, material is pressed into medicinal dispersing tablets, every 0.7g.
The present invention also provides the using method of above-mentioned Chinese medicine composition tablet, is specially: oral tablet, preferably each 3～4, each 3 times.
The present invention also provides the application of above-mentioned Chinese medicine composition in the medicine for the preparation for the treatment of acute pharyngitis.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
The concrete preparation of embodiment 1 granule 1
By Herba Sarcandrae 47g, Rhizoma Polygoni Cuspidati 51g, Rhizoma Acori Graminei 28g, Caulis Mahoniae 39g, Semen Sterculiae Lychnophorae 34g, Radix Scutellariae 82g, Periostracum Cicadae 21g, Dioscorea panthaica Prain et Burkill 47g, Radix Asteris 31g, Flos Sophorae 18g, Galla Chinensis 44g, Fructus Gleditsiae Abnormalis 27g, Herba Solidaginis 30g, Indigo Naturalis 66g, Herba Ephedrae 35g, Rhizoma Panacis Majoris 44g, Rhizoma Polygonati Odorati 23g, Fructus Hippophae 31g, Fructus Chebulae 25g, Radix Scrophulariae 32g, Caulis Piperis Kadsurae 40g, Rhizoma Panacis Japonici 35g, Lasiosphaera Seu Calvatia 21g, Radix Adenophorae 36g, Rhizoma Dioscoreae 44g, catechu 24g and Radix Glycyrrhizae 31g send in mixing and blending machine and are uniformly mixed, then pour in multi-function extractor, add the distilled water of 5kg to decoct 3 hours, in decoction process, control steam pressure at 0.1Mpa, temperature is controlled at 100 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add the distilled water of 5kg to decoct 3 hours, in decoction process, control steam pressure at 0.1Mpa, temperature is controlled at 100 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution, with hydrochloric acid, regulating the pH value of total extracting solution is 6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin are 2:1, first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 6 times of the quality of macroporous adsorbent resin be 80%, collect eluent, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dried cream powder is broken into fine powder, spraying is dry, in dried fine powder, add the cane sugar powder of 1kg corn dextrin and 3.4kg, mix, granulate, splitting and filling, every bag of 10g.
The concrete preparation of embodiment 2 granules 2
By Herba Sarcandrae 45g, Rhizoma Polygoni Cuspidati 49g, Rhizoma Acori Graminei 26g, Caulis Mahoniae 37g, Semen Sterculiae Lychnophorae 32g, Radix Scutellariae 80g, Periostracum Cicadae 19g, Dioscorea panthaica Prain et Burkill 45g, Radix Asteris 29g, Flos Sophorae 16g, Galla Chinensis 42g, Fructus Gleditsiae Abnormalis 25g, Herba Solidaginis 28g, Indigo Naturalis 64g, Herba Ephedrae 33g, Rhizoma Panacis Majoris 42g, Rhizoma Polygonati Odorati 21g, Fructus Hippophae 29g, Fructus Chebulae 23g, Radix Scrophulariae 30g, Caulis Piperis Kadsurae 38g, Rhizoma Panacis Japonici 33g, Lasiosphaera Seu Calvatia 19g, Radix Adenophorae 34g, Rhizoma Dioscoreae 42g, catechu 22g and Radix Glycyrrhizae 29g send in mixing and blending machine and are uniformly mixed, then pour in multi-function extractor, add the distilled water of 5kg to decoct 3 hours, in decoction process, control steam pressure at 0.8Mpa, temperature is controlled at 100 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add the distilled water of 5kg to decoct 3 hours, in decoction process, control steam pressure at 0.08Mpa, temperature is controlled at 100 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution, with hydrochloric acid, regulating the pH value of total extracting solution is 5.5, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin are 2:1, first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 6 times of the quality of macroporous adsorbent resin be 75%, collect eluent, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dried cream powder is broken into fine powder, spraying is dry, in dried fine powder, add the cane sugar powder of 1kg corn dextrin and 3.4kg, mix, granulate, splitting and filling, every bag of 10g.
The concrete preparation of embodiment 3 granules 3
By Herba Sarcandrae 49g, Rhizoma Polygoni Cuspidati 53g, Rhizoma Acori Graminei 30g, Caulis Mahoniae 41g, Semen Sterculiae Lychnophorae 36g, Radix Scutellariae 84g, Periostracum Cicadae 23g, Dioscorea panthaica Prain et Burkill 49g, Radix Asteris 33g, Flos Sophorae 20g, Galla Chinensis 46g, Fructus Gleditsiae Abnormalis 29g, Herba Solidaginis 32g, Indigo Naturalis 68g, Herba Ephedrae 37g, Rhizoma Panacis Majoris 46g, Rhizoma Polygonati Odorati 25g, Fructus Hippophae 33g, Fructus Chebulae 27g, Radix Scrophulariae 34g, Caulis Piperis Kadsurae 42g, Rhizoma Panacis Japonici 37g, Lasiosphaera Seu Calvatia 23g, Radix Adenophorae 38g, Rhizoma Dioscoreae 46g, catechu 26g and Radix Glycyrrhizae 33g send in mixing and blending machine and are uniformly mixed, then pour in multi-function extractor, add the distilled water of 5kg to decoct 3 hours, in decoction process, control steam pressure at 0.8Mpa, temperature is controlled at 100 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add the distilled water of 5kg to decoct 3 hours, in decoction process, control steam pressure at 0.1Mpa, temperature is controlled at 100 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution, with hydrochloric acid, regulating the pH value of total extracting solution is 6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin are 2:1, first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 6 times of the quality of macroporous adsorbent resin be 70%, collect eluent, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dried cream powder is broken into fine powder, spraying is dry, in dried fine powder, add the cane sugar powder of 1kg corn dextrin and 3.4kg, mix, granulate, splitting and filling, every bag of 10g.
The concrete preparation of embodiment 4 tablets 1
By Herba Sarcandrae 47g, Rhizoma Polygoni Cuspidati 51g, Rhizoma Acori Graminei 28g, Caulis Mahoniae 39g, Semen Sterculiae Lychnophorae 34g, Radix Scutellariae 82g, Periostracum Cicadae 21g, Dioscorea panthaica Prain et Burkill 47g, Radix Asteris 31g, Flos Sophorae 18g, Galla Chinensis 44g, Fructus Gleditsiae Abnormalis 27g, Herba Solidaginis 30g, Indigo Naturalis 66g, Herba Ephedrae 35g, Rhizoma Panacis Majoris 44g, Rhizoma Polygonati Odorati 23g, Fructus Hippophae 31g, Fructus Chebulae 25g, Radix Scrophulariae 32g, Caulis Piperis Kadsurae 40g, Rhizoma Panacis Japonici 35g, Lasiosphaera Seu Calvatia 21g, Radix Adenophorae 36g, Rhizoma Dioscoreae 44g, catechu 24g and Radix Glycyrrhizae 31g send in mixing and blending machine and are uniformly mixed, then pour in multi-function extractor, add the distilled water of 5kg to decoct 3 hours, in decoction process, control steam pressure at 0.1Mpa, temperature is controlled at 100 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add the distilled water of 5kg to decoct 3 hours, in decoction process, control steam pressure at 0.1Mpa, temperature is controlled at 100 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution, with hydrochloric acid, regulating the pH value of total extracting solution is 6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin are 2:1, first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 6 times of the quality of macroporous adsorbent resin be 80%, collect eluent, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dried cream powder is broken into fine powder, spraying is dry, by the dry spraying fine powder 900g obtaining and the polyvinylpyrrolidone of 720g, the sodium carboxymethyl cellulose of 360g, after the microcrystalline Cellulose of 1.35kg mixes, with the determining alcohol of 200g, be that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 50 ℃ of temperature ranges, with 16 mesh sieve granulate, and adds after the magnesium stearate of 70g and the micropowder silica gel of 50g, material is pressed into medicinal dispersing tablets, every 0.7g.
Embodiment 5 Chinese medicine composition toxicity tests detect
Laboratory animal
50 of kunming mices (being provided by Qingdao City's laboratory animal and zoopery center), female half and half, body weight 18～22g, be divided into 5 groups, every group 10,50 of Cavia porcelluss (being provided by Qingdao City's laboratory animal and zoopery center), male and female half and half, body weight is 250g ~ 300g, in 14 week age, be divided into 5 groups, 10 every group, experimental animal enters cleaner assay chamber and raises 7d, observes animal activity, feed, defecation and all without after abnormal, starts test.With all steel rat breeding cage (50cm × 32cm × 22.5cm), raise, male and female are divided cage.With the nursing of Mus full-valence pellet feed, by the keeper special messenger's feeding and management through training.Animal housing's illumination abundance, heating ventilation and air-conditioning equipment is good, 18～25 ℃ of room temperatures, relative humidity 50%～70%, test chamber is regularly sterilization routinely.
Experimental agents
Granule 1 prepared by the 1st group to the 3rd group gavage embodiment of the present invention 1 to embodiment 3 of kunming mice is to granule 3, granule 1 to granule 3 is dissolved in water, dissolve completely, be prepared into the solution of 1g/ml, the 4th group of tablet prepared by the gavage embodiment of the present invention 41 of kunming mice, tablet 1 is dissolved in water, dissolve completely, be prepared into the solution of 1g/ml, granule 1 prepared by the 1st group to the 3rd group gavage embodiment of the present invention 1 to embodiment 3 of Cavia porcellus is to granule 3, granule 1 to granule 3 is dissolved in water, dissolve completely, be prepared into the solution of 1g/ml, the 4th group of tablet prepared by the gavage embodiment of the present invention 41 of Cavia porcellus, tablet 1 is dissolved in water, dissolve completely, be prepared into the solution of 1g/ml.
Kunming mice acute toxicity testing
By the 1st group to the 4th group of kunming mice respectively according to method administration above, each 0.4ml/10g, blank group gavage equivalent normal saline, after front fasting (the can't help water) 12h of test, the 1st group to the 4th group every day 1 gastric infusion, 14d, records the situations such as tested mice behavior, activity, food ration, body weight, feces, death continuously, and not dead mice is put to death and performs an autopsy on sb． after 14d.
The 1st group of mice to the 4th group of 40g (crude drug)/kg dosed administration of Chinese medicine composition, saw that mice hair color was smooth, feces is brown the same day, quality is rarer soft, ingest, movable less, mice activity after the 2nd day, food ration, body weight gain, feces etc. all recover normally, with relatively no significant difference of blank group; And in 14d without dead and other extremely occurs, two groups perform an autopsy on sb． after putting to death simultaneously, each main organs (heart, liver, spleen, lung, kidney) no abnormality seen by the naked eye.
Cavia porcellus repetitively administered toxicity test
By the 1st group to the 4th group of Cavia porcellus respectively according to method administration above, each 0.4ml/10g, blank group gavage equivalent normal saline, after front fasting (the can't help water) 12h of test, the 1st group to the 4th group every day 1 gastric infusion, continuous 5 weeks, record the situations such as tested Cavia porcellus behavior, activity, food ration, body weight, feces, death, Guinea Pigs Died was not put to death and is performed an autopsy on sb． after 5 weeks.
Experimental animal behavioral activity, diet, defecation and shown no obvious abnormalities by situations such as hair color pools within whole experimental period, have no vomiting, sialorrhea, shed tears, the symptom such as dyspnea.Duration of test has indivedual animal deads, through cage, takes up Anatomical Observation, and dead animal shows no obvious abnormalities, for administration improper lethal.
After each treated animal administration, growth promoter is good, and body weight gain and blank group relatively show no obvious abnormalities.
After off-test, put to death animal, dissect immediately, the major organs such as perusal brain, heart, liver, spleen, lungs, kidney, each organ surface is smooth, without adhesion, color and luster is normal, has no hyperemia, swelling, hemorrhage, downright bad, adhesion, gastrointestinal is without expansion, and intestinal wall is without abnormal phenomenas such as edema, hemorrhage, ulcer.
Heart: myocardial cell band is clear, and core is placed in the middle, interstitial has no vasodilation and cell infiltration; Visceral pericardium, endocardium are without extremely.Liver: hepatocyte is arranged and is strand, and lobules of liver structure is clear, and portal area has no cell infiltration and fibrous connective tissue hypertrophy, hepatocyte polygon, slurry is abundant, and core is justified greatly.Spleen: fibrous capsule is complete, without thickening, acini lienalis is high-visible, and trabecularism is normal, and red pulp, white pulp are clear, have no degeneration, necrosis and cell infiltration.Lungs: bronchioles structural integrity, be methodically arranged, alveolar wall structural integrity, lung interval and bronchus are excellent, and intracavity, without obvious exudate, has no degeneration, necrosis and cell infiltration.Kidney: Renal Cortex, medullary substance, glomerule structure are normal, and messangial cell number does not increase, blood capillary tube chamber is without expansion, renal cells, kidney interstitial no abnormality seen.Brain: organizational structure is normal, neurocyte, neurogliocyte form are normal, each layer of neuronal cell Non Apparent Abnormality.
Embodiment 6 zooperies
Laboratory animal
60 of kunming mices (being provided by Qingdao City's laboratory animal and zoopery center), female half and half, body weight 18～22g, is divided into 3 groups, 20 every group.
Experimental agents
Granule 1 prepared by the present invention, the ammonia that concentration is 15%; Glacial acetic acid; Laryngeal spray.
Grouping and administration
By experiment treatment conditions, be divided into Normal group, model group, treatment group, granule 1 prepared by treatment group gavage embodiment 1, is dissolved in granule 1 in water, dissolves completely, is prepared into the solution of 1g/ml, every day gavage medicine 20g/(kgd) 14d continuously.Treatment group and model group are since 12d atomization, and each 15% ammonia of upper and lower noon of 3d sprays its pharyngeal 1 time continuously, at every turn with aerosol apparatus spray 3 times.Normal group and model group Cavia porcellus gavage every day normal saline 0.5mL/100g, the pharyngeal spray distilled water of normal control Cavia porcellus.
The research of antitussive effect
Cough latent period and the 2min of the above-mentioned group rat of observed and recorded, the cough number of times in 5min.
Antiinflammatory action research
On the swollen impact of rat granuloma
The sterilizing cotton balls that above-mentioned group weighs at 20mg of the subcutaneous each implantation of left and right hind leg footpath portion under aseptic condition the each Mus of administration 10d.After administration 14d weighs, put to death rat, open former otch, cotton balls is taken out together with connective tissue around, reject fatty tissue, in 70 ℃ of drying in oven, weigh, calculate each group of granuloma weight, by claim granulation tissue weight deduct cotton balls original weight and obtain granuloma weight.
The detection of serum interleukin-6 and tumor necrosis factor-alpha TNF
Above-mentioned rat is put to death front abdominal aortic blood, by test kit, requires to detect IL-6 and TNF.
Statistical method
Carry out statistical disposition with SPSS for Windows10.0 version software.Measurement data adopts t check, and enumeration data adopts χ
2check.
Result
The impact of Chinese medicine composition of the present invention on guinea pig cough, the results are shown in Table 1.
The impact of table 1 Chinese medicine composition on guinea pig cough
| Group | n | Incubation period | 2min | 5min |
| Normal group | 20 | 15.27±1.27 | 17.33±2.16 | 18.51±1.73 |
| Model group | 20 | 25.33±1.94 | 32.18±2.03 | 41.92±1.62 |
| Treatment group | 20 | 20.82±1.03 | 22.51±2.30 | 19.35±1.84 |
As can be seen from Table 1, adopt Chinese medicine composition of the present invention can obviously extend cough latent period, reduce cough number of times.
The impact of Chinese medicine composition on Cavia porcellus granuloma induced by implantation of cotton pellets, the results are shown in Table 2.
The impact of table 2 Chinese medicine composition on Cavia porcellus granuloma induced by implantation of cotton pellets
By table 2, can find out, adopt Chinese medicine composition of the present invention can obviously suppress the Cavia porcellus granuloma that cotton balls causes.
The impact of Chinese medicine composition on Cavia porcellus IL-6 and TNF content, the results are shown in Table 3.
The impact of table 3 Chinese medicine composition on Cavia porcellus IL-6 and TNF content
| Group | n | IL-6（pg/mL） | TNF（ng/mL） |
| Normal group | 20 | 120.59±23.61 | 77.63±5.32 |
| Model group | 20 | 235.91±27.31 | 90.22±4.91 |
| Treatment group | 20 | 153.99±30.17 | 81.19±3.61 |
As can be seen from Table 3, Chinese medicine composition of the present invention can significantly reduce the content of IL-6 and TNF.
Embodiment 7 clinical datas
Physical data
All 260 routine acute pharyngitis patients are the patient in December, 2009～2011 year July, get rid of intentionally, serious disease and the psychotic such as liver, kidney.Wherein male 152 examples, female's 108 examples, 6～64 years old age, 37 years old mean age.Main clinic symptoms: pharyngalgia, silent, dry pharynx, acataposis, cough, the not high or low heat of body temperature (lower than 39 ℃), headache, the whole body is uncomfortable or ache, constipation with dry stool, yellow urine, red tongue, yellow and greasy fur, pharyngeal obvious hyperemia or edema, antiadoncus etc., laboratory inspection: numeration of leukocyte is normal or on the low side, percentage of lymphocyte raises; X-ray checks pulmonary's Non Apparent Abnormality discovery.
Experiment grouping
Patient is divided into 2 groups immediately, treatment group 150 examples, matched group 110 examples, 87 examples in treatment group, female's 73 examples, case is the longest 3 days, the shortest 12h, average (1.52 ± 0.61) day.Matched group man 67 examples, female's 43 examples; The course of disease is the longest 2 days, the shortest 12h, average course of disease (1.30 ± 0.49) day.The comparison of 2 groups of case physical data, learns and processes there was no significant difference (P > 0.05) by statistics, has comparability.
Western medicine diagnose standard
(1) medical history: suffer from cold, tired, tobacco and wine are excessive, the reasons such as various physicochemical irritations.(2) clinical symptoms: pharyngeal dry, scorching hot pain or swallow pain; Heating fear of cold, inappetence, surrounding is ached.Cough, watery nasal discharge.(3) check: pharyngeal mucosa hyperemia, color are scarlet, pharynx rear wall lymph follicle and isthmus faucium redness, local or have Huang, white secretions, uvula soft palate edema.Possess and have pharyngeal symptom, and have the above inspection positive to levy, in conjunction with medical history diagnosable be acute pharyngitis.
Tcm diagnosis
Disease is seen: pharyngalgia, dry pharynx are scorching hot, dysphagia, mouthful micro-thirsty, and aversion to cold is light, and heating is heavy, cough deep, and the yellow skin of coughing up phlegm, red swelling of the pharynx, uvula redness, pharynx rear wall follicle hypertrophy, tongue tip side of red, tongue fur BOHUANG, floating and rapid pulse.
Symptom and sign grade scale
1. pharyngalgia: light (+): pharyngeal dull pain, does not affect and swallow; In (++): pharyngeal pain, while swallowing, pain increases the weight of; Heavy (+++) pharyngeal severe pain, dysphagia.2. heating: light (+): 37.5 ℃～38 ℃ of body temperature; In (++): 38.1 ℃～39 ℃ of body temperature; Heavy (+++): body temperature is more than 39.1 ℃.3. staphyledema: light (+): uvula enlargement, does not affect and swallow; In (++): uvula enlargement is sagging, has foreign body sensation while swallowing; Heavy (+++): uvula enlargement, contact pharyngeally, do not swallow foreign body sensation also obvious.4. pharyngeal mucosa hyperemia: light (+): bottleneck throat is slightly congested, but not obvious; In (++): between weight, color is red; Heavy (+++): red swelling of the pharynx is obvious, and color is red.5. cough is coughed up phlegm light (+): be interrupted cough daytime, and expectorant easily brings up, and expectorant is that white is sticky; In (++): cough is coughed up phlegm, and between weight, expectorant is glutinous yellow; Heavy (+++): the frequent or play of cough is round the clock coughed, and the thick Huang of abundant expectoration, is not easy to bring up, and impact is had a rest.
Observation index
1. symptom: mainly observe pharyngeal pain, heating; 2. pharyngeal sign: pharyngeal mucosa hyperemia, staphyledema; 3. temperature taking: during treatment, each patient detects body temperature routinely, and performs record.
Therapeutic Method
Granule 1 prepared by the oral embodiment of the present invention 1 for the treatment of group, is dissolved in warm water and is taken, and each oral 10g, 5 days 1 courses for the treatment of, takes 2 courses for the treatment of at every day 3 times.
Matched group Administration of roxithromycin capsule, every day 2 times, each 150mg.
Criterion of therapeutical effect
Recovery from illness: medication alleviates with interior symptom on the 3rd, disappears with interior clinical symptoms and sign on the 5th; Effective: in medication 5 days, symptom alleviates, most of sign disappears; Effective: in medication 5 days, symptom alleviates, part sign disappears; Invalid: medication 5 days with interior clinical symptoms and sign without improvement.
Statistical method
Carry out statistical disposition with SPSS for Windows10.0 version software.Measurement data adopts t check, and enumeration data adopts χ
2check.
Result
Clinical efficacy comparison, the results are shown in Table 4.
Table 4 liang group Clinical efficacy comparison
As can be seen from Table 4, adopt Chinese medicine composition of the present invention can obviously improve the therapeutic efficiency of acute pharyngitis.
Two groups of patients cure required time comparison, the results are shown in Table 5.
A table 5 liang group patient cures required time comparison
| Group | Cure number | Average cure time (my god) |
| Treatment group | 81 | 2.63±0.51 |
| Matched group | 35 | 4.03±0.77 |
As can be seen from Table 5, adopt Chinese medicine composition of the present invention can obviously reduce the treatment time of acute pharyngitis.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. a Chinese medicine composition that is used for the treatment of acute pharyngitis, is characterized in that: the crude drug of described Chinese medicine composition only consists of Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae;
In described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Sarcandrae 42 weight portion～52 weight portions, Rhizoma Polygoni Cuspidati 46 weight portion～56 weight portions, Rhizoma Acori Graminei 23 weight portion～33 weight portions, Caulis Mahoniae 34 weight portion～44 weight portions, Semen Sterculiae Lychnophorae 29 weight portion～39 weight portions, Radix Scutellariae 77 weight portion～87 weight portions, Periostracum Cicadae 16 weight portion～26 weight portions, Dioscorea panthaica Prain et Burkill 42 weight portion～52 weight portions, Radix Asteris 26 weight portion～36 weight portions, Flos Sophorae 13 weight portion～23 weight portions, Galla Chinensis 39 weight portion～49 weight portions, Fructus Gleditsiae Abnormalis 22 weight portion～32 weight portions, Herba Solidaginis 25 weight portion～35 weight portions, Indigo Naturalis 61 weight portion～71 weight portions, Herba Ephedrae 30 weight portion～40 weight portions, Rhizoma Panacis Majoris 39 weight portion～49 weight portions, Rhizoma Polygonati Odorati 18 weight portion～28 weight portions, Fructus Hippophae 26 weight portion～36 weight portions, Fructus Chebulae's 20 weight portion～30 weight portions, Radix Scrophulariae 27 weight portion～37 weight portions, Caulis Piperis Kadsurae 35 weight portion～45 weight portions, Rhizoma Panacis Japonici 30 weight portion～40 weight portions, Lasiosphaera Seu Calvatia 16 weight portion～26 weight portions, Radix Adenophorae 31 weight portion～41 weight portions, Rhizoma Dioscoreae 39 weight portion～49 weight portions, catechu 19 weight portion～29 weight portions and Radix Glycyrrhizae 26 weight portion～36 weight portions.
2. Chinese medicine composition as claimed in claim 1, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Sarcandrae 45 weight portion～49 weight portions, Rhizoma Polygoni Cuspidati 49 weight portion～53 weight portions, Rhizoma Acori Graminei 26 weight portion～30 weight portions, Caulis Mahoniae 37 weight portion～41 weight portions, Semen Sterculiae Lychnophorae 32 weight portion～36 weight portions, Radix Scutellariae 80 weight portion～84 weight portions, Periostracum Cicadae 19 weight portion～23 weight portions, Dioscorea panthaica Prain et Burkill 45 weight portion～49 weight portions, Radix Asteris 29 weight portion～33 weight portions, Flos Sophorae 16 weight portion～20 weight portions, Galla Chinensis 42 weight portion～46 weight portions, Fructus Gleditsiae Abnormalis 25 weight portion～29 weight portions, Herba Solidaginis 28 weight portion～32 weight portions, Indigo Naturalis 64 weight portion～68 weight portions, Herba Ephedrae 33 weight portion～37 weight portions, Rhizoma Panacis Majoris 42 weight portion～46 weight portions, Rhizoma Polygonati Odorati 21 weight portion～25 weight portions, Fructus Hippophae 29 weight portion～33 weight portions, Fructus Chebulae's 23 weight portion～27 weight portions, Radix Scrophulariae 30 weight portion～34 weight portions, Caulis Piperis Kadsurae 38 weight portion～42 weight portions, Rhizoma Panacis Japonici 33 weight portion～37 weight portions, Lasiosphaera Seu Calvatia 19 weight portion～23 weight portions, Radix Adenophorae 34 weight portion～38 weight portions, Rhizoma Dioscoreae 42 weight portion～46 weight portions, catechu 22 weight portion～26 weight portions and Radix Glycyrrhizae 29 weight portion～33 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Sarcandrae 47 weight portions, Rhizoma Polygoni Cuspidati 51 weight portions, Rhizoma Acori Graminei 28 weight portions, Caulis Mahoniae 39 weight portions, Semen Sterculiae Lychnophorae 34 weight portions, Radix Scutellariae 82 weight portions, Periostracum Cicadae 21 weight portions, Dioscorea panthaica Prain et Burkill 47 weight portions, Radix Asteris 31 weight portions, Flos Sophorae 18 weight portions, Galla Chinensis 44 weight portions, Fructus Gleditsiae Abnormalis 27 weight portions, Herba Solidaginis 30 weight portions, Indigo Naturalis 66 weight portions, Herba Ephedrae 35 weight portions, Rhizoma Panacis Majoris 44 weight portions, Rhizoma Polygonati Odorati 23 weight portions, Fructus Hippophae 31 weight portions, Fructus Chebulae's 25 weight portions, Radix Scrophulariae 32 weight portions, Caulis Piperis Kadsurae 40 weight portions, Rhizoma Panacis Japonici 35 weight portions, Lasiosphaera Seu Calvatia 21 weight portions, Radix Adenophorae 36 weight portions, Rhizoma Dioscoreae 44 weight portions, catechu 24 weight portions and Radix Glycyrrhizae 31 weight portions.
4. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that: the dosage form of described Chinese medicine composition is tablet, soft capsule, powder, granule, pill, mixture.
5. the application of the Chinese medicine composition described in claim 1 or 2 in the medicine for the preparation for the treatment of acute pharyngitis.
6. the preparation method of the Chinese medicine composition described in claim 1 or 2, is characterized in that: when the dosage form of described Chinese medicine composition is granule, is specially,
The first step, described each crude drug component is sent in mixing and blending machine and is uniformly mixed, then pour in multi-function extractor, add with respect to the distilled water of 4～6 times of each crude drug quality sums and decoct 2～3 hours, in decoction process, control steam pressure at 0.05～0.1Mpa, temperature is controlled at 98～102 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add with respect to the distilled water of 4～6 times of each crude drug quality sums and decoct 2～3 hours, in decoction process, control steam pressure at 0.05～0.1Mpa, temperature is controlled at 98～102 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution,
Second step, with hydrochloric acid, regulating the pH value of total extracting solution is 5～6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin be 2～3:1, and first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 5～7 times of the quality of macroporous adsorbent resin be 60%～80%, collect eluent, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, be ground into fine powder, spraying is dry;
The 3rd step adds corn dextrin and cane sugar powder in dried fine powder, mixes, granulate, splitting and filling, with respect to the dried cream powder of 100 weight portions, the addition of corn dextrin is 80 weight portion～120 weight portions, and the addition of cane sugar powder is 300 weight portion～400 weight portions.
7. the preparation method of the Chinese medicine composition described in claim 1 or 2, is characterized in that: when the dosage form of described Chinese medicine composition is tablet, is specially,
The first step, described each crude drug component is sent in mixing and blending machine and is uniformly mixed, then pour in multi-function extractor, add with respect to the distilled water of 4～6 times of each crude drug quality sums and decoct 2～3 hours, in decoction process, control steam pressure at 0.05～0.1Mpa, temperature is controlled at 98～102 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add with respect to the distilled water of 4～6 times of each crude drug quality sums and decoct 2～3 hours, in decoction process, control steam pressure at 0.05～0.1Mpa, temperature is controlled at 98～102 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution,
Second step, with hydrochloric acid, regulating the pH value of total extracting solution is 5～6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin be 2～3:1, and first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 5～7 times of the quality of macroporous adsorbent resin be 60%～80%, collect eluent, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, be ground into fine powder, spraying is dry;
The 3rd step, after the microcrystalline Cellulose of the sodium carboxymethyl cellulose of the polyvinylpyrrolidone of dry spraying fine powder 100 weight portions that obtain and 60～100 weight portions, 30～50 weight portions, 120～180 weight portions is mixed, with the determining alcohol of 20～30 weight portions, be that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 45 ℃～50 ℃ temperature ranges, with 16 mesh sieve granulate, and add after the magnesium stearate of 7～9 weight portions and the micropowder silica gel of 6～8 weight portions, material is pressed into medicinal dispersing tablets.
8. one kind is used for the treatment of the Chinese medicinal composition granules of acute pharyngitis, it is characterized in that: the crude drug of described Chinese medicinal composition granules only consists of Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae
In described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Sarcandrae 42 weight portion～52 weight portions, Rhizoma Polygoni Cuspidati 46 weight portion～56 weight portions, Rhizoma Acori Graminei 23 weight portion～33 weight portions, Caulis Mahoniae 34 weight portion～44 weight portions, Semen Sterculiae Lychnophorae 29 weight portion～39 weight portions, Radix Scutellariae 77 weight portion～87 weight portions, Periostracum Cicadae 16 weight portion～26 weight portions, Dioscorea panthaica Prain et Burkill 42 weight portion～52 weight portions, Radix Asteris 26 weight portion～36 weight portions, Flos Sophorae 13 weight portion～23 weight portions, Galla Chinensis 39 weight portion～49 weight portions, Fructus Gleditsiae Abnormalis 22 weight portion～32 weight portions, Herba Solidaginis 25 weight portion～35 weight portions, Indigo Naturalis 61 weight portion～71 weight portions, Herba Ephedrae 30 weight portion～40 weight portions, Rhizoma Panacis Majoris 39 weight portion～49 weight portions, Rhizoma Polygonati Odorati 18 weight portion～28 weight portions, Fructus Hippophae 26 weight portion～36 weight portions, Fructus Chebulae's 20 weight portion～30 weight portions, Radix Scrophulariae 27 weight portion～37 weight portions, Caulis Piperis Kadsurae 35 weight portion～45 weight portions, Rhizoma Panacis Japonici 30 weight portion～40 weight portions, Lasiosphaera Seu Calvatia 16 weight portion～26 weight portions, Radix Adenophorae 31 weight portion～41 weight portions, Rhizoma Dioscoreae 39 weight portion～49 weight portions, catechu 19 weight portion～29 weight portions and Radix Glycyrrhizae 26 weight portion～36 weight portions,
The preparation method of described granule is specially,
The first step, described each crude drug component is sent in mixing and blending machine and is uniformly mixed, then pour in multi-function extractor, add with respect to the distilled water of 4～6 times of each crude drug quality sums and decoct 2～3 hours, in decoction process, control steam pressure at 0.05～0.1Mpa, temperature is controlled at 98～102 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add with respect to the distilled water of 4～6 times of each crude drug quality sums and decoct 2～3 hours, in decoction process, control steam pressure at 0.05～0.1Mpa, temperature is controlled at 98～102 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution,
Second step, with hydrochloric acid, regulating the pH value of total extracting solution is 5～6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin be 2～3:1, and first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 5～7 times of the quality of macroporous adsorbent resin be 60%～80%, collect eluent, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, be ground into fine powder, spraying is dry;
The 3rd step adds corn dextrin and cane sugar powder in dried fine powder, mixes, granulate, splitting and filling, with respect to the dried cream powder of 100 weight portions, the addition of corn dextrin is 80 weight portion～120 weight portions, and the addition of cane sugar powder is 300 weight portion～400 weight portions.
9. one kind is used for the treatment of the Chinese medicine composition tablet of acute pharyngitis, it is characterized in that: the crude drug of described Chinese medicine composition tablet only consists of Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae
In described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Sarcandrae 42 weight portion～52 weight portions, Rhizoma Polygoni Cuspidati 46 weight portion～56 weight portions, Rhizoma Acori Graminei 23 weight portion～33 weight portions, Caulis Mahoniae 34 weight portion～44 weight portions, Semen Sterculiae Lychnophorae 29 weight portion～39 weight portions, Radix Scutellariae 77 weight portion～87 weight portions, Periostracum Cicadae 16 weight portion～26 weight portions, Dioscorea panthaica Prain et Burkill 42 weight portion～52 weight portions, Radix Asteris 26 weight portion～36 weight portions, Flos Sophorae 13 weight portion～23 weight portions, Galla Chinensis 39 weight portion～49 weight portions, Fructus Gleditsiae Abnormalis 22 weight portion～32 weight portions, Herba Solidaginis 25 weight portion～35 weight portions, Indigo Naturalis 61 weight portion～71 weight portions, Herba Ephedrae 30 weight portion～40 weight portions, Rhizoma Panacis Majoris 39 weight portion～49 weight portions, Rhizoma Polygonati Odorati 18 weight portion～28 weight portions, Fructus Hippophae 26 weight portion～36 weight portions, Fructus Chebulae's 20 weight portion～30 weight portions, Radix Scrophulariae 27 weight portion～37 weight portions, Caulis Piperis Kadsurae 35 weight portion～45 weight portions, Rhizoma Panacis Japonici 30 weight portion～40 weight portions, Lasiosphaera Seu Calvatia 16 weight portion～26 weight portions, Radix Adenophorae 31 weight portion～41 weight portions, Rhizoma Dioscoreae 39 weight portion～49 weight portions, catechu 19 weight portion～29 weight portions and Radix Glycyrrhizae 26 weight portion～36 weight portions,
The preparation method of described tablet is specially,
The first step, described each crude drug component is sent in mixing and blending machine and is uniformly mixed, then pour in multi-function extractor, add with respect to the distilled water of 4～6 times of each crude drug quality sums and decoct 2～3 hours, in decoction process, control steam pressure at 0.05～0.1Mpa, temperature is controlled at 98～102 ℃, filter, obtain extracting solution, filtering residue is poured in multi-function extractor again, add with respect to the distilled water of 4～6 times of each crude drug quality sums and decoct 2～3 hours, in decoction process, control steam pressure at 0.05～0.1Mpa, temperature is controlled at 98～102 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution,
Second step, with hydrochloric acid, regulating the pH value of total extracting solution is 5～6, to regulate the total extracting solution after pH value to be added on large adsorption hole resin column subsequently, total quality of extracting solution and the mass ratio of macroporous adsorbent resin be 2～3:1, and first water rushes to effluent colourless, the ethanol elution that to use subsequently with respect to the determining alcohol of 5～7 times of the quality of macroporous adsorbent resin be 60%～80%, collect eluent, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, be ground into fine powder, spraying is dry;
The 3rd step, after the microcrystalline Cellulose of the sodium carboxymethyl cellulose of the polyvinylpyrrolidone of dry spraying fine powder 100 weight portions that obtain and 60～100 weight portions, 30～50 weight portions, 120～180 weight portions is mixed, with the determining alcohol of 20～30 weight portions, be that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 45 ℃～50 ℃ temperature ranges, with 16 mesh sieve granulate, and add after the magnesium stearate of 7～9 weight portions and the micropowder silica gel of 6～8 weight portions, material is pressed into medicinal dispersing tablets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210593558.6A CN103041160B (en) | 2012-12-29 | 2012-12-29 | Traditional Chinese medicine composition for curing acute pharyngitis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210593558.6A CN103041160B (en) | 2012-12-29 | 2012-12-29 | Traditional Chinese medicine composition for curing acute pharyngitis and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103041160A CN103041160A (en) | 2013-04-17 |
| CN103041160B true CN103041160B (en) | 2014-05-07 |
Family
ID=48054171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210593558.6A Active CN103041160B (en) | 2012-12-29 | 2012-12-29 | Traditional Chinese medicine composition for curing acute pharyngitis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103041160B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109316551A (en) * | 2018-11-20 | 2019-02-12 | 山东罗欣乐康制药有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating acpuei pharyngitis |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1142377A (en) * | 1995-08-04 | 1997-02-12 | 胶州市中医医院 | Chinese medicine prescription for chronic pharyngitis and preparation thereof |
| CN101249213A (en) * | 2008-03-24 | 2008-08-27 | 李运乃 | Hot drink cake preparation for treating chronic pharyngitis caused by yin deficiency of lung and stomach |
| CN101732500A (en) * | 2008-11-11 | 2010-06-16 | 戚寰 | Medicine for preventing and treating acute and chronic pharyngitis and sphagitis |
| CN101954062A (en) * | 2010-09-29 | 2011-01-26 | 安政权 | Medicament for treating chronic pharyngitis |
| CN102309687A (en) * | 2011-09-22 | 2012-01-11 | 王璐 | Medicament for treating faucitis |
-
2012
- 2012-12-29 CN CN201210593558.6A patent/CN103041160B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1142377A (en) * | 1995-08-04 | 1997-02-12 | 胶州市中医医院 | Chinese medicine prescription for chronic pharyngitis and preparation thereof |
| CN101249213A (en) * | 2008-03-24 | 2008-08-27 | 李运乃 | Hot drink cake preparation for treating chronic pharyngitis caused by yin deficiency of lung and stomach |
| CN101732500A (en) * | 2008-11-11 | 2010-06-16 | 戚寰 | Medicine for preventing and treating acute and chronic pharyngitis and sphagitis |
| CN101954062A (en) * | 2010-09-29 | 2011-01-26 | 安政权 | Medicament for treating chronic pharyngitis |
| CN102309687A (en) * | 2011-09-22 | 2012-01-11 | 王璐 | Medicament for treating faucitis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103041160A (en) | 2013-04-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101766787B (en) | Enema liquid for treating hyperpyrexia and cough and asthma | |
| CN104147536B (en) | A kind of pharmaceutical composition treating hemorrhoid and preparation method thereof | |
| CN103169883B (en) | Traditional Chinese medicine for treating infantile jaundice | |
| CN104288745A (en) | Traditional Chinese medicine for treating CG (Chronic Gastritis) | |
| CN103735679B (en) | Chinese medicine composition of a kind of diminishing inflammation and clearing pharynx and preparation method thereof | |
| CN103041160B (en) | Traditional Chinese medicine composition for curing acute pharyngitis and preparation method thereof | |
| CN105434952A (en) | Medicine for treating scarlatina and preparation method thereof | |
| CN101708286B (en) | Chinese patent medicament for treating sjogren's syndrome and intractable oral ulcer, and preparation method thereof | |
| CN103028041B (en) | Traditional Chinese medicine composition for treating acute nasosinusitis of children and preparation method of traditional Chinese medicine composition | |
| CN105412665A (en) | Medicine for treating measles and preparation method thereof | |
| CN104435641A (en) | Traditional Chinese medicine preparation for treating hyperthyroidism | |
| CN103386104B (en) | Traditional Chinese medicine composite for curing erysipelas and preparation method thereof | |
| CN103784806A (en) | Traditional Chinese medicine for treating wind-heat urticaria | |
| CN103041172B (en) | Traditional Chinese medicine composition for curing chronic nasosinusitis and preparation method thereof | |
| CN100506272C (en) | Psoriasis treating Chinese medicine preparation | |
| CN104043037A (en) | Medicinal preparation used for treating acute exacerbation of chronic obstructive pulmonary disease | |
| CN101095905A (en) | Traditional Chinese medicinal preparation for curing psoriasis | |
| CN105963586A (en) | Medicine for treating lung abscess and preparation method thereof | |
| CN105535435A (en) | Traditional Chinese medicine composition for treating fire excess from yin deficiency and preparation method thereof | |
| CN105148070A (en) | Traditional Chinese medicine composition for treating chronic bronchitis | |
| CN105232879A (en) | Traditional Chinese medicine preparation treating chronic pharyngitis and preparation technology thereof | |
| CN105213848A (en) | Be used for the treatment of the medicine of accumulation of heat in the heart and spleen type recurrent oral ulceration | |
| CN105168847A (en) | Traditional Chinese medicine for treating helicobacter pylori infected peptic ulcer | |
| CN104208380A (en) | Capsule for treating septicemia and preparation method | |
| CN119280321A (en) | A Chinese medicine composition for clearing away heat and detoxifying, relieving sore throat and reducing swelling, and its preparation method and use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Li Na Inventor after: Ren Jian Inventor after: Liu Junyan Inventor before: Request for anonymity |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: REQUEST NOT TO RELEASE THE NAME TO: LI NA REN JIAN LIU JUNYAN |
|
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20171020 Address after: 401147 Chongqing city Yubei District Longxi street new irrigation Road No. 18 building 11 24-11 City Ambassador Patentee after: Chongqing view Intellectual Property Service Co.,Ltd. Address before: 266071 Shandong province Qingdao City Road No. 19 east red room unit 7 Patentee before: QINGDAO HENGBO INSTRUMENT Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20181213 Address after: 510700 No. 39 Ruihe Road, Huangpu District, Guangzhou City, Guangdong Province Patentee after: GUANGZHOU LIXIN PHARMACEUTICALS CO.,LTD. Address before: 401147 Guobin City, No. 18 Xinji Avenue, Longxi Street, Yubei District, Chongqing City, 11 blocks, 24-11 Patentee before: Chongqing view Intellectual Property Service Co.,Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Traditional Chinese medicine composition for curing acute pharyngitis and preparation method thereof Effective date of registration: 20190628 Granted publication date: 20140507 Pledgee: Senbao Branch of Guangzhou Bank Co.,Ltd. Pledgor: GUANGZHOU LIXIN PHARMACEUTICALS CO.,LTD. Registration number: 2019440000243 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20200730 Granted publication date: 20140507 Pledgee: Senbao Branch of Guangzhou Bank Co.,Ltd. Pledgor: GUANGZHOU LIXIN PHARMACEUTICALS Co.,Ltd. Registration number: 2019440000243 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Traditional Chinese medicine composition for treating acute pharyngitis and its preparation method Effective date of registration: 20200813 Granted publication date: 20140507 Pledgee: Senbao Branch of Guangzhou Bank Co.,Ltd. Pledgor: GUANGZHOU LIXIN PHARMACEUTICALS Co.,Ltd. Registration number: Y2020440000231 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210830 Granted publication date: 20140507 Pledgee: Senbao Branch of Guangzhou Bank Co.,Ltd. Pledgor: GUANGZHOU LIXIN PHARMACEUTICALS Co.,Ltd. Registration number: Y2020440000231 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Traditional Chinese medicine composition for treating acute pharyngitis and its preparation method Effective date of registration: 20210830 Granted publication date: 20140507 Pledgee: Tianhe sub branch of Bank of Guangzhou Co.,Ltd. Pledgor: GUANGZHOU LIXIN PHARMACEUTICALS Co.,Ltd. Registration number: Y2021980008655 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20221018 Granted publication date: 20140507 Pledgee: Tianhe sub branch of Bank of Guangzhou Co.,Ltd. Pledgor: GUANGZHOU LIXIN PHARMACEUTICALS CO.,LTD. Registration number: Y2021980008655 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |