CN104208380A - Capsule for treating septicemia and preparation method - Google Patents
Capsule for treating septicemia and preparation method Download PDFInfo
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- CN104208380A CN104208380A CN201410524470.8A CN201410524470A CN104208380A CN 104208380 A CN104208380 A CN 104208380A CN 201410524470 A CN201410524470 A CN 201410524470A CN 104208380 A CN104208380 A CN 104208380A
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Abstract
The invention discloses a capsule for treating septicemia and a preparation method, and belongs to the field of traditional Chinese medicine. The capsule comprises the effective ingredients composed of the raw materials of japanese balanophora, salvinia natans, rheum forrestii, thunberg fritillary bulb, ludwigia hyssopifolia, cape jasmine, caudate sweetleaf root, tripterospermum, platycodon grandiflorum, rhodomyrtus tomentosa, rorippa indica, clerodendrum cyrtophyllum, sanguisorba officinalis, honeysuckle, brasenia and ajuga taiwanensis. According to the capsule, the medicines are matched and complement each other; the capsule has the effects of clearing heat, dissipating static, purging fire for removing toxin, and cooling blood and hemostasis; the body immunity can be improved after taking orally; septicemia caused by various factors can be treated well; in addition, the capsule is convenient to take; the clinical application shows that the capsule has the advantages of being quick to act, small in cost, lasting in treatment effect, and not recurring after recovery, and free of any toxic and side effects; the capsule can be widely applied to the clinical treatment of septicemia.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of capsule and preparation method that is used for the treatment of septicemia.
Background technology
Septicemia refers to that pathogenic bacterium or conditioned pathogen invade blood circulation, and in blood growth and breeding, produce toxin and the acute systemic infection that occurs.With multiple abscess, the course of disease is called pyemia compared with elder to septicemia.
Different and different with the power of resistance with kind, quantity, virulence and the infant age of pathogenic bacterium.The lighter only has nonspecific infection symptom, and septic shock, DIC, multiple organ dysfunction syndrome etc. can occur severe one.The most onset of septic patient is hurried, first has fear of cold or shiver with cold, then high heat, and pattern of fever is indefinite, remittent fever or continued fever; Weak, serious symptom malnutrition and young infant can be without heatings, and even body temperature is lower than normally.Lethargy or dysphoria, can there is pale complexion or steel gray, obnubilation in severe patient.Extremity tip is fainted cold, rapid breathing, and heart rate is accelerated, blood pressure drops, also can there is jaundice in infant.The visible various skin injurys of part infant, common with petechia, ecchymosis, scarlet fever sample erythra, urticaria sample erythra.Also often there are vomiting, diarrhoea, stomachache, even hematemesis, have blood in stool; Can there is toxical paralytic ileus or dehydration, acidosis in severe patient.
Suffer from after septicemia, don't fail to treat early, septicemia is breakneck, start to cause Sepsis shape, cause heating, fear of cold, lethargy dysphoria, when serious, also can cause rapid breathing, heart rate is accelerated, and blood pressure drops causes life danger, also can cause erythra, scarlet fever, vomiting and diarrhoea, even hematemesis, serious also can cause dehydration, acidosis, arthroncus, moving obstacle, can also cause Liver abscesses, myocarditis, heart failure, confusion etc.
The method of existing treatment septicemia is mainly lain up, and strengthens nutrition, supplements appropriate vitamin, maintain water, electrolyte and acid-base balance, transfuse blood if desired, blood plasma, albumin and gamma globulin, highly can give Physical temperature-lowering when hot, irritated person gives tranquilizer etc.But the treatment of present Therapeutic Method is comparatively slow, and effect is very undesirable.In recent years the research of relevant Chinese medicine and extract for preventing and treating septicemia thereof comes into one's own day by day, and has obtained major progress, for treatment septicemia, has had important breakthrough.
Summary of the invention
The invention provides a kind of capsule and preparation method that is used for the treatment of septicemia; The selected medical material compatibility of capsule of the present invention brings out the best in each other, having heat clearing away dismisses, the effect of eliminating fire and detoxication, cooling blood for hemostasis, by the human body immune function that improved for oral administration, the septicemia causing for the various causes of disease all has good efficacy, and taking convenience, through clinical practice, finds, capsule of the present invention has that rapid, with low cost, the curative effect of effect is lasting, non-relapse after healing, advantage without any side effects, can be widely used in the clinical treatment of septicemia.
For achieving the above object, technical scheme of the present invention is implemented as follows:
A capsule that is used for the treatment of septicemia, raw material composition and the parts by weight of making described capsule effective ingredient are:
The husky seven 60-84 part Bulbus Fritillariae Thunbergii 50-74 parts of Herba balanophorae japonicae 55-85 part Japanese pagodatree leaf 55-79 part
The imperial 45-70 part Fructus Gardeniae 46-68 part Radix Symplocoris Caudatae 34-56 part Herba Tripterospermi 35-56 part of grass
Radix Platycodonis 30-50 part mountain Shen 30-50 Fen Herba Rorippae 25-45 part Folium Isatidis 20-35 part
Radix Sanguisorbae 20-45 part Flos Lonicerae 15-30 part Herba braseniaeel. 10-25 part Herba boeae clarkeanae 10-25 part.
Raw material composition and the parts by weight of making described capsule effective ingredient are:
68 parts of 7 78 parts of Bulbus Fritillariae Thunbergiis of 73 parts of sand of 77 parts of Japanese pagodatree leaf of Herba balanophorae japonicae
51 parts of 50 parts of Herba Tripterospermis of grass dragon 62 parts of Radix Symplocoris Caudataes of 63 portions of Fructus Gardeniaes
31 parts of 40 parts of Folium Isatidis of 45 parts of mountain Shen of Radix Platycodonis, 45 Fen Herba Rorippae
21 parts of 21 parts of Herba boeae clarkeanaes of 26 parts of Herba braseniaeel. of 38 portions of Flos Loniceraes of Radix Sanguisorbae.
Raw material composition and the parts by weight of making described capsule effective ingredient are:
62 parts of 7 72 parts of Bulbus Fritillariae Thunbergiis of 67 parts of sand of 70 parts of Japanese pagodatree leaf of Herba balanophorae japonicae
45 parts of 44 parts of Herba Tripterospermis of grass dragon 55 parts of Radix Symplocoris Caudataes of 56 portions of Fructus Gardeniaes
27 parts of 35 parts of Folium Isatidis of 40 parts of mountain Shen of Radix Platycodonis, 40 Fen Herba Rorippae
17 parts of 17 parts of Herba boeae clarkeanaes of 22 parts of Herba braseniaeel. of 31 portions of Flos Loniceraes of Radix Sanguisorbae.
Raw material composition and the parts by weight of making described capsule effective ingredient are:
54 parts of 7 66 parts of Bulbus Fritillariae Thunbergiis of 61 parts of sand of 63 parts of Japanese pagodatree leaf of Herba balanophorae japonicae
40 parts of 38 parts of Herba Tripterospermis of grass dragon 48 parts of Radix Symplocoris Caudataes of 49 portions of Fructus Gardeniaes
23 parts of 30 parts of Folium Isatidis of 35 parts of mountain Shen of Radix Platycodonis, 35 Fen Herba Rorippae
13 parts of 13 parts of Herba boeae clarkeanaes of 18 parts of Herba braseniaeel. of 24 portions of Flos Loniceraes of Radix Sanguisorbae.
A preparation method that is used for the treatment of the capsule of septicemia, comprises following processing step:
(1) Herba balanophorae japonicae and Radix Sanguisorbae decontamination are cleaned, as for mashing in container, added the distilled water of 3 times of amounts, stir, extract 1～2 hour, filter, obtain filtrate for later use;
(2) Japanese pagodatree leaf, sand seven, grass dragon, Fructus Gardeniae, Radix Symplocoris Caudatae and Herba braseniaeel. are cleaned to decontamination, put into container, add the distilled water of 8 times of amounts, soak after 3-4 hour, boil 2-3 hour, extract; Again add 6 times of amount distilled water, boil 1-2 hour, extract; Merge extracted twice liquid, filter, filtrate is condensed at 60 ℃ to 1.15-1.25 thick paste doubly, drying under reduced pressure, standby;
(3) get Bulbus Fritillariae Thunbergii, Herba Tripterospermi, mountain Shen, Folium Isatidis, Flos Lonicerae and Herba boeae clarkeanae decontamination, microwave drying, smashs to pieces, is placed in mortar and grinds into powder, crosses 180 order fine powders, standby;
(4) get Radix Platycodonis decontamination, put into slow fire and burn hot frying pan, fry to surperficial micro-yellow, taking-up is dried in the air cool, is placed in mortar and grinds into powder, crosses 160 order fine powders, standby;
(5) Qu Herba Rorippae decontaminations, clean, and after putting into container and smashing to pieces, the distilled water that adds 3-5 doubly to measure, stirs, and filters, and gets filtrate for later use;
(6) fine powder that filtrate step (1) and (5) being made, thick paste, step (3) and the step (4) that step (2) makes make mixes, and makes capsule, is the capsule that is used for the treatment of septicemia of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Herba balanophorae japonicae: bitter in the mouth, puckery, cold in nature; Return lung, large intestine channel.Cooling blood for hemostasis, heat-clearing and toxic substances removing.Main cough spitting of blood, metrorrhagia, discharging fresh blood stool, swelling and pain of hemorrhoid, syphilis, treats skin ulcer, and child penis is swollen.< < Traditional Chinese Medicine in Sichuan will > > carries: " clearing away lung-heat, relieving heat toxin.Control cough and spit blood, metrorrhagia and swelling and pain of hemorrhoid.”
Japanese pagodatree leaf: bitter in the mouth, property is flat; Return liver, stomach warp.Purging liver-fire, removing pathogenic heat from blood and toxic substance from the body, removing dampness and killing parasites.Main pediatric epilepsy scared, high fever, hemorrhoidal hamorrhage, hematuria, hemorrhoid, eczema, scabies, carbuncle skin ulcer furuncle is swollen.
Husky seven: bitter in the mouth, cool in nature.Clearing away lung-heat to relieve cough, removing pathogenic heat from blood and toxic substance from the body, promoting blood circulation and stopping pain.Main cough due to lung-heat, laryngopharynx swelling and pain, has blood in stool, traumatic hemorrhage, traumatic injury, rheumatic arthralgia.
Bulbus Fritillariae Thunbergii: bitter in the mouth, cold in nature; Return lung, heart channel.Removing heat-phlegm, powder detoxifcation.Control cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, sore swollen toxin.The positive > > of < < book on Chinese herbal medicine carries: " great order lung abscess lung withers, and cough with asthma is spitted blood, and mental disorder, falls most in epistaxis; kind relieving stagnation, the pain that relieves the pain, and relieving distension is full, clearing away liver-fire; improve visual and auditory acuity, except seasonal epidemic pathogens dysphoria with smothery sensation, jaundice stranguria with urinary obstruction, the hematuria of having blood in stool; Relieving heat toxin, kills parasites and treats sore throat, scrofula, and acute mastitis carbuncle on the back, all carbuncle and ulcer toxic swellings, damp and hot malignant boil, anal fistula, incised wound is hemorrhage, burn pain, than Bulbus Fritillariae Cirrhosae, the merit of falling clearly, not less than several times.”
Grass dragon: acrid in the mouth, micro-hardship, cool in nature.Deliver heat clearing away, removing toxic substances diuresis, cooling blood for hemostasis.Main cold, fever, laryngopharynx swelling and pain, toothache, aphtha of the mouth and tongue, damp-heat dysentery, edema, drenches pain, infantile malnutrition, spitting of blood, hemoptysis, spits blood, has blood in stool, metrorrhagia, carbuncle furuncle is swollen.
Fructus Gardeniae: bitter in the mouth, cold in nature; GUIXIN, lung, tri-jiao channel.Pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, pathogenic fire purging dissipating blood stasis.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles, infectious hepatitis, traumatic injury, acute toothache; External treatment bruise pain.< < property of medicine opinion > >: “ Sha female ground beetle poison, the malicious wind that reduces phlegm and internal heat, sharp five types of stranguria, main attacked by pestiferous factors, diuresis, separates five kinds of jaundice, improving eyesight, disease heat extraction and the xerostomia of quenching one's thirst while controlling, conjunctival congestion and swelling pain.”
Radix Symplocoris Caudatae: bitter in the mouth, pungent, property is flat; Return liver, stomach warp.Clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, wind-expelling pain-stopping.Main jaundice, has loose bowels, dysentery, metrorrhagia, acute toothache, headache, rheumatic arthralgia.The herbal > > in east, < < Fujian carries: " removing heat from blood, brings down a fever, cough-relieving, and the therapeutic method to keep the adverse QI flowing downwards, relieves inflammation or internal heat, improving eyesight, heat radiation, dehumidifying, resolving depression, dispels the wind.Control wind-fire headache, vexed heating, jaundice, thirsty, metrorrhagia, tongue boil, pained, chronic dysentery.”
Herba Tripterospermi: acrid in the mouth, sweet, bitter, cold in nature; Return lung, kidney channel.Clearing away lung-heat to relieve cough, cooling blood for hemostasis, diuresis removing toxic substances.Main cough due to lung-heat, pulmonary tuberculosis spitting of blood, lung abscess, nephritis, acute mastitis, carbuncle sore furuncle is swollen, wound hemorrhage, venom.< < Zhiwu Mingshi Tukao > > carries: " smash and apply all poison.”
Radix Platycodonis: bitter in the mouth, pungent, property is flat; Be included into lung, stomach warp.Open lung qi dispersing gas, the evacuation of pus of eliminating the phlegm.Control exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache.< < Japan hanako materia medica > >: " lower all gas, stop cramp caused by acute vomiting and diarrhea, and trusted subordinate's distending pain is mended five kinds of over strain; foster the spirit of nobility, evil removing is warded off temperature, tonify deficiency expectorant; broken lump in the abdomen, and the evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat.”
Mountain Shen: sweet in the mouth, puckery, property is flat.Nourishing blood and hemoslasis, astringing intestine to stop diarrhea controlling nocturnal emission with astringent drugs.Control blood deficiency, spit blood, epistaxis, has blood in stool, dysentery, proctoptosis, tinnitus, seminal emission, metrorrhagia, leukorrhagia.< < book on Chinese herbal medicine asks former > > to carry: " dysentery relieving, red and white leukorrhea, promoting regeneration of the tissue and arresting bleeding.”
Herba Rorippae: acrid in the mouth, hardship, slightly warm in nature; Return lung, Liver Channel.Expelling phlegm for arresting cough, the cold expelling that induces sweat, promoting blood circulation and detoxication, dampness removing jaundice eliminating.Main cough phlegm dyspnea, cold, fever, measles is sent out not smooth thoroughly, rheumatic arthralgia, laryngopharynx swelling and pain, furuncle carbuncle, dermatitis rhus, amenorrhea, traumatic injury, jaundice, edema.< < conventional glossary of Herbs and Drugs > > among the people carries: " furunculosis is controlled in external; Venting QI-blood for oral administration.Control women's breast sick, and control cough, jaundice." modern medicine study confirms that ， Herba Rorippae all has inhibitory action to 4 strain streptococcus pneumoniae and 4 influenzae strain bacillus, all has inhibitory action to streptococcus pneumoniae and influenza.
Folium Isatidis: bitter in the mouth, cold in nature; Return stomach, heart channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis.Main fever caused by exogenous pathogenic factors intenseness of heat excessive thirst, laryngopharynx swelling and pain, aphtha, jaundice, pyrotoxic dysentery, acute enteritis, swollen ulcer drug, epistaxis, stranguria with blood, traumatic hemorrhage.Modern medicine study confirmation, Folium Isatidis all has bactericidal action to multiple dysentery bacterium, and meningococcus is had to killing action.
Radix Sanguisorbae: bitter in the mouth, acid, cold in nature; Enter liver, large intestine channel.Blood on removing heat from blood, heat-clearing and toxic substances removing.Control haematemesis, epistaxis, dysentery, metrorrhagia, hemorrhoidal hamorrhage, anal fistula, carbuncle, eczema, incised wound, burn.The positive > > of < < book on Chinese herbal medicine carries: " relieve inflammation or internal heat tomorrow.Control foul leukorrhea anal fistula, puerperal, cloudy gas scattered and disappeared.Also hold back night sweat, treat fullness-oppression in the epigastrium caused by heat." modern medicine study confirmation, Radix Sanguisorbae contains a large amount of tannins, has stronger convergence and pressor effect, can reduce the permeability of blood vessel, reduces inflammatory exudation, also has obvious bactericidal action simultaneously, can resist charrin's disease.
Flos Lonicerae: sweet in the mouth, cold in nature; Return lung, the heart, stomach warp.Heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.The conventional Chinese herbal medicine handbook > > of the < < of Guangzhou army carries: " heat-clearing and toxic substances removing.Control fever caused by exogenous pathogens cough, enteritis, bacillary dysentery, measles, parotitis, septicemia, furuncle toxic swelling, appendicitis, trauma infection contamination, children's's hidradenitis suppurativa.Make herbal tea, can prevent heatstroke, flu and infectious intestinal disease." modern medicine study confirmation, Flos Lonicerae is better than alcohol extract to leptospiral bacteriostasis, can delay the pathological changes effect of Respirovirus to cell.
Herba braseniaeel.: sweet in the mouth, cold in nature; Return liver, spleen channel.Inducing diuresis to remove edema, heat-clearing and toxic substances removing.Main hygropyretic dysentery, jaundice, edema, dysuria, pyretic toxicity carbuncle.< < Japan hanako materia medica > > carries: " control hot subcutaneous ulcer, thick the intestines and stomach, the peace part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, separates hundred poison of drug.”
Herba boeae clarkeanae: mildly bitter flavor, puckery, property is flat; Return stomach warp.Heat-clearing and toxic substances removing, astringing to arrest bleeding.Main Stomach duodenum ulcer, hepatitis, hematuria leukorrhagia, skin infection, traumatic hemorrhage.In < <, traditional Chinese medicines are planted illustrated handbook > > and are carried: " adjust digestive function, control gastric ulcer, duodenal ulcer.”
The present invention compared with prior art, has following beneficial effect:
The selected medical material compatibility of capsule of the present invention brings out the best in each other, having heat clearing away dismisses, the effect of eliminating fire and detoxication, cooling blood for hemostasis, by the human body immune function that improved for oral administration, the septicemia causing for the various causes of disease all has good efficacy, and taking convenience, through clinical practice, finds, capsule of the present invention has that rapid, with low cost, the curative effect of effect is lasting, non-relapse after healing, advantage without any side effects, can be widely used in the clinical treatment of septicemia.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of capsule effective ingredient of the present invention forms and weight is:
The husky seven 82g Bulbus Fritillariae Thunbergii 72g of Herba balanophorae japonicae 83g Japanese pagodatree leaf 77g
The imperial 68g Fructus Gardeniae 65g Radix Symplocoris Caudatae 54g Herba Tripterospermi 54g of grass
Radix Platycodonis 48g mountain Shen 48g Herba Rorippae 43g Folium Isatidis 33g
Radix Sanguisorbae 43g Flos Lonicerae 29g Herba braseniaeel. 24g Herba boeae clarkeanae 24g.
The processing step of capsule preparation method thereof of the present invention is:
(1) Herba balanophorae japonicae and Radix Sanguisorbae decontamination are cleaned, as for mashing in container, added the distilled water of 3 times of amounts, stir, extract 1～2 hour, filter, obtain filtrate for later use;
(2) Japanese pagodatree leaf, sand seven, grass dragon, Fructus Gardeniae, Radix Symplocoris Caudatae and Herba braseniaeel. are cleaned to decontamination, put into container, add the distilled water of 8 times of amounts, soak after 3-4 hour, boil 2-3 hour, extract; Again add 6 times of amount distilled water, boil 1-2 hour, extract; Merge extracted twice liquid, filter, filtrate is condensed at 60 ℃ to 1.15-1.25 thick paste doubly, drying under reduced pressure, standby;
(3) get Bulbus Fritillariae Thunbergii, Herba Tripterospermi, mountain Shen, Folium Isatidis, Flos Lonicerae and Herba boeae clarkeanae decontamination, microwave drying, smashs to pieces, is placed in mortar and grinds into powder, crosses 180 order fine powders, standby;
(4) get Radix Platycodonis decontamination, put into slow fire and burn hot frying pan, fry to surperficial micro-yellow, taking-up is dried in the air cool, is placed in mortar and grinds into powder, crosses 160 order fine powders, standby;
(5) Qu Herba Rorippae decontaminations, clean, and after putting into container and smashing to pieces, the distilled water that adds 3-5 doubly to measure, stirs, and filters, and gets filtrate for later use;
(6) fine powder that filtrate step (1) and (5) being made, thick paste, step (3) and the step (4) that step (2) makes make mixes, and makes capsule, is the capsule that is used for the treatment of septicemia of the present invention.
Usage and dosage: oral, warm water delivery service after meal, each 2 (every 0.75g), and every day 2 times, each 1 time sooner or later 10 days is a course for the treatment of, can fully recover 3-4 the course for the treatment of, the person's of being in a bad way meal with wine amount of adding of following the doctor's advice.Embodiment 2
The raw material of capsule effective ingredient of the present invention forms and weight is:
The husky seven 78g Bulbus Fritillariae Thunbergii 68g of Herba balanophorae japonicae 77g Japanese pagodatree leaf 73g
The imperial 63g Fructus Gardeniae 62g Radix Symplocoris Caudatae 50g Herba Tripterospermi 51g of grass
Radix Platycodonis 45g mountain Shen 45g Herba Rorippae 40g Folium Isatidis 31g
Radix Sanguisorbae 38g Flos Lonicerae 26g Herba braseniaeel. 21g Herba boeae clarkeanae 21g.
Capsule preparation method thereof processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
The raw material of capsule effective ingredient of the present invention forms and weight number is:
The husky seven 72g Bulbus Fritillariae Thunbergii 62g of Herba balanophorae japonicae 70g Japanese pagodatree leaf 67g
The imperial 56g Fructus Gardeniae 55g Radix Symplocoris Caudatae 44g Herba Tripterospermi 45g of grass
Radix Platycodonis 40g mountain Shen 40g Herba Rorippae 35g Folium Isatidis 27g
Radix Sanguisorbae 31g Flos Lonicerae 22g Herba braseniaeel. 17g Herba boeae clarkeanae 17g.
Capsule preparation method thereof processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
The raw material of capsule effective ingredient of the present invention forms and weight number is:
The husky seven 66g Bulbus Fritillariae Thunbergii 54g of Herba balanophorae japonicae 63g Japanese pagodatree leaf 61g
The imperial 49g Fructus Gardeniae 48g Radix Symplocoris Caudatae 38g Herba Tripterospermi 40g of grass
Radix Platycodonis 35g mountain Shen 35g Herba Rorippae 30g Folium Isatidis 23g
Radix Sanguisorbae 24g Flos Lonicerae 18g Herba braseniaeel. 13g Herba boeae clarkeanae 13g.
Capsule preparation method thereof processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection:
As the capsule for the treatment of septicemia, the routine clinical observation of septic patient 200 of selecting Wo Yuanhuo outer court to make a definite diagnosis, patient is divided into two groups at random, treatment group 100 examples, male's 55 examples wherein, women's 45 examples, age 15-50 year, 30 years old mean age, the course of disease 2 months-6 years; Matched group 100 examples, male's 55 examples wherein, women's 45 examples, age 20-45 year, 33 years old mean age, the course of disease 2 months-5 years.The course of disease, the degrees of symptoms of two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group patient takes medicine of the present invention, oral, warm water delivery service after meal, each 2 (every 0.75g), every day 2 times, each 1 time sooner or later 10 days is a course for the treatment of, takes continuously 3-4 the course for the treatment of, the person's of being in a bad way meal with wine amount of adding of following the doctor's advice.
Matched group is taken antibiotic, by specification use, and the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
3, efficacy determination:
(1) cure: the septicemia transference cures such as heating, fear of cold, lethargy, dysphoria, rapid breathing, heart rate quickening, blood pressure drops, vomiting and diarrhoea, it is normal that body function is recovered.
(2) effective: above-mentioned symptom is alleviated to some extent.
(3) invalid: disease is unchanged.
4, result:
Take in the treatment group of medicine of the present invention, cure 65 examples, effective 30 examples, invalid 5 examples, cure rate is 65%, total effective rate 95%.
In matched group, cure 25 examples, effective 45 examples, invalid 30 examples, cure rate is 25%, total effective rate 70%.
Above result demonstration, treatment group cure rate and total effective rate are apparently higher than matched group.
5, model case is for example:
1, shut out certain, female, 45 years old, workman, Zhejiang Hangzhou people.After patient flu, there is fear of cold, heating, after the treatment of locality, bring down a fever, but there is anorexia, become thin, weak.Carry out a medical examination subsequently, have a medical check-up and show two lung audibles and a little moist rale, abdominal part, without extremely, is diagnosed as the hot disease of height that septicemia causes.To our hospital afterwards, take capsule of the present invention, take after 2 courses for the treatment of, transference cure, with after the 3rd course for the treatment of, recovery from illness, does not recur again.
2, rather certain, man, 32 years old, the office worker of foreign enterprise, Law Firm Suzhou Jiangsu people.Before patient is admitted to hospital and checks, occur that fear of cold, heating, the body temperature of unknown cause is up to 39.5 ℃.Rear patient is admitted to hospital and checks, intravenous injection Radix Bupleuri or compound recipe ammonia woods barbital, bring down a fever not obvious, with being down to 36 ℃ after the measures such as lytic cocktail blanket cooling on the rocks, right upper quadrant of the abdomen dull pain, companion's discontinuity diarrhoea, appetite obviously declines, and rear diagnosis is the above-mentioned symptom that septicemia causes, take capsule of the present invention after 4 courses for the treatment of, transference cure, follows up a case by regular visits to, without recurrence.
3, Huang, female, 22 years old, company sold, Xiamen of Fujian Province people.Before half a year, there is 3 about Semen Glyciness size erythema, desquamation in the two hips of patient, companion's pruritus, rear erythra increases, can partly disappear, after increase the weight of gradually, after admission examination, be diagnosed as septicemia, it is poor with medication effect to give.Taking capsule of the present invention after 2 courses for the treatment of, symptom takes a turn for the better, continue to take after 2 courses for the treatment of, and transference cure, physical recovery is normal, not recurrence.
4, Dong, man, 14 years old, student, Shandong Zibo people.There is the symptoms such as poor appetite, weak, xanthochromia, vomiting, diarrhoea in patient.Take voluntarily after " Bao Jishui ", abdominal distention symptom takes a turn for the better, regular not medical again, after occur again xanthochromia, even cough, expectoration, amount less, the symptom such as white, the heating of color, high fever reaches 39.5 degree, then medical to being admitted to hospital, give with medicine after xanthochromia increase the weight of, vomiting, tells after feed.After take capsule of the present invention after one month, symptom disappears completely, pain disappears, livelihood restoration is normal.
5, Wang, man, 26 years old, business personnel, people from Kaifeng.Patient because of Right Lower Abdomen pain, severe headache, feel sick, vomit to our hospital, give with medicine after, symptom fails to alleviate.After take capsule of the present invention after 2 courses for the treatment of, symptom takes a turn for the better, and continues to take after 4 courses for the treatment of, clinical symptom disappearance, has a meal without uncomfortable, after check, without recurrence.
6, Xu certain, female, 18 years old, student, Dongguan, Guangdong people.Before about half a year, there is after school lethargy in patient, high heat, and body temperature reaches 39.6 ℃, give after cefotaxime sodium and levofloxacin dead point, body temperature slightly declines, second day, heat more very, is had a medical check-up and is shown as disturbance of consciousness, is deep coma state, there is left upper extremity involuntary movement in patient, AD is septicemia, once took multi-medicament and treat all to no effect, rear to our hospital after, start to take capsule of the present invention after 4 courses for the treatment of, symptom disappears completely, and livelihood restoration is normal.
Claims (5)
1. a capsule that is used for the treatment of septicemia, is characterized in that: raw material composition and the parts by weight of making described capsule effective ingredient are:
The husky seven 60-84 part Bulbus Fritillariae Thunbergii 50-74 parts of Herba balanophorae japonicae 55-85 part Japanese pagodatree leaf 55-79 part
The imperial 45-70 part Fructus Gardeniae 46-68 part Radix Symplocoris Caudatae 34-56 part Herba Tripterospermi 35-56 part of grass
Radix Platycodonis 30-50 part mountain Shen 30-50 Fen Herba Rorippae 25-45 part Folium Isatidis 20-35 part
Radix Sanguisorbae 20-45 part Flos Lonicerae 15-30 part Herba braseniaeel. 10-25 part Herba boeae clarkeanae 10-25 part.
2. a kind of capsule that is used for the treatment of septicemia according to claim 1, is characterized in that: the raw material of making described capsule effective ingredient forms and parts by weight are:
68 parts of 7 78 parts of Bulbus Fritillariae Thunbergiis of 73 parts of sand of 77 parts of Japanese pagodatree leaf of Herba balanophorae japonicae
51 parts of 50 parts of Herba Tripterospermis of grass dragon 62 parts of Radix Symplocoris Caudataes of 63 portions of Fructus Gardeniaes
31 parts of 40 parts of Folium Isatidis of 45 parts of mountain Shen of Radix Platycodonis, 45 Fen Herba Rorippae
21 parts of 21 parts of Herba boeae clarkeanaes of 26 parts of Herba braseniaeel. of 38 portions of Flos Loniceraes of Radix Sanguisorbae.
3. a kind of capsule that is used for the treatment of septicemia according to claim 1, is characterized in that: the raw material of making described capsule effective ingredient forms and parts by weight are:
62 parts of 7 72 parts of Bulbus Fritillariae Thunbergiis of 67 parts of sand of 70 parts of Japanese pagodatree leaf of Herba balanophorae japonicae
45 parts of 44 parts of Herba Tripterospermis of grass dragon 55 parts of Radix Symplocoris Caudataes of 56 portions of Fructus Gardeniaes
27 parts of 35 parts of Folium Isatidis of 40 parts of mountain Shen of Radix Platycodonis, 40 Fen Herba Rorippae
17 parts of 17 parts of Herba boeae clarkeanaes of 22 parts of Herba braseniaeel. of 31 portions of Flos Loniceraes of Radix Sanguisorbae.
4. a kind of capsule that is used for the treatment of septicemia according to claim 1, is characterized in that: the raw material of making described capsule effective ingredient forms and parts by weight are:
54 parts of 7 66 parts of Bulbus Fritillariae Thunbergiis of 61 parts of sand of 63 parts of Japanese pagodatree leaf of Herba balanophorae japonicae
40 parts of 38 parts of Herba Tripterospermis of grass dragon 48 parts of Radix Symplocoris Caudataes of 49 portions of Fructus Gardeniaes
23 parts of 30 parts of Folium Isatidis of 35 parts of mountain Shen of Radix Platycodonis, 35 Fen Herba Rorippae
13 parts of 13 parts of Herba boeae clarkeanaes of 18 parts of Herba braseniaeel. of 24 portions of Flos Loniceraes of Radix Sanguisorbae.
5. a preparation method for the capsule that is used for the treatment of septicemia as described in claim 1-4, is characterized in that: comprise following processing step:
(1) Herba balanophorae japonicae and Radix Sanguisorbae decontamination are cleaned, as for mashing in container, added the distilled water of 3 times of amounts, stir, extract 1～2 hour, filter, obtain filtrate for later use;
(2) Japanese pagodatree leaf, sand seven, grass dragon, Fructus Gardeniae, Radix Symplocoris Caudatae and Herba braseniaeel. are cleaned to decontamination, put into container, add the distilled water of 8 times of amounts, soak after 3-4 hour, boil 2-3 hour, extract; Again add 6 times of amount distilled water, boil 1-2 hour, extract; Merge extracted twice liquid, filter, filtrate is condensed at 60 ℃ to 1.15-1.25 thick paste doubly, drying under reduced pressure, standby;
(3) get Bulbus Fritillariae Thunbergii, Herba Tripterospermi, mountain Shen, Folium Isatidis, Flos Lonicerae and Herba boeae clarkeanae decontamination, microwave drying, smashs to pieces, is placed in mortar and grinds into powder, crosses 180 order fine powders, standby;
(4) get Radix Platycodonis decontamination, put into slow fire and burn hot frying pan, fry to surperficial micro-yellow, taking-up is dried in the air cool, is placed in mortar and grinds into powder, crosses 160 order fine powders, standby;
(5) Qu Herba Rorippae decontaminations, clean, and after putting into container and smashing to pieces, the distilled water that adds 3-5 doubly to measure, stirs, and filters, and gets filtrate for later use;
(6) fine powder that filtrate step (1) and (5) being made, thick paste, step (3) and the step (4) that step (2) makes make mixes, and makes capsule, is the described capsule that is used for the treatment of septicemia.
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Application publication date: 20141217 |