CN104435454A - Medicine for treating chronic endometritis and preparation method of medicine - Google Patents

Medicine for treating chronic endometritis and preparation method of medicine Download PDF

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CN104435454A
CN104435454A CN201410801839.5A CN201410801839A CN104435454A CN 104435454 A CN104435454 A CN 104435454A CN 201410801839 A CN201410801839 A CN 201410801839A CN 104435454 A CN104435454 A CN 104435454A
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medicine
herba
chronic endometritis
folium
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潘洪国
王玉华
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Abstract

The invention discloses a medicine for treating chronic endometritis and a preparation method of the medicine, belonging to the field of traditional Chinese medicine. The active ingredients of the medicine are prepared from the following raw materials: lotus seed, cortex ailanthi, swamp violet, caragana microphylla, seed of Chinese waxgourd, henry ormosia wood or root, root of Chinese crossostephium, broadleaf holly leaf, celastrus orbiculatus, cattail pollen, aloe leaf, nightshade, Japanese farfugium herb, root of sheathed monkshood, hemp spike and soroseris erysimoides. The medicine disclosed by the invention is appropriate in compatibility of the selected medicinal materials, and consistent with the principles of traditional Chinese medicine and modern medicine; the medicine has functions of nourishing blood and yin, promoting qi circulation and relieving pain, promoting circulation of blood and removing blood stasis; in treating chronic endometritis, the medicine has the advantages of being good in curative effect, rapid in effect taking, short in treatment course and free from toxic and side effect; and the medicine is significant in curative effect, free from reoccurrence after recovery, safe and reliable, low in cost, and worthy of wide popularization and application.

Description

A kind of medicine and preparation method for the treatment of chronic endometritis
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine and preparation method for the treatment of chronic endometritis.
Background technology
Endometritis can be divided into acute endometritis and chronic endometritis, even if there is chronic accessory inflammation very widely, endometrium may be still completely normal.There are good drain condition and periodicity Endarterectomy mainly due to uterine cavity, make the few chance extended stationary periods of inflammation in endometrium, but as thorough in acute stages treated, or often there is the source of infection, then can recurrent exerbation.Chronic endometritis is the most common cause causing miscarrying, and about 90% miscarriage is relevant with gynecological inflammation.
Endometrium swelling, pale.Check under mirror: in inner membrance interstitial, have a lot of plasma cell and lymphocytic infiltration.More plasma cell occurs diagnosis very important.The visible fibroblast of inflammation time person more of a specified duration and blood capillary proliferation.Senile endometrium inflammation presents blood vessel wall thickness, sclerosis, sometimes has calcification.When pathological changes is serious, there is ulcer local.During the atrophy of inner membrance body of gland, micromicro has squamous metaplasia on the surface, has large stretch of squamous epithelial cancer to cover whole cavity of uterus inwall, be called uterus ichthyosis when squamous metaplasia is extensive.Post abortum endometritis should note the whether existence such as fine hair, decidua, particularly miscarries comparatively of a specified duration, and fine hair can high degradation, even can not find fine hair, but the surrounding of blood vessel of being everlasting can find the block decidua tissue of the sheet be dispersed in.
At present, the method for the treatment of chronic endometritis is more both at home and abroad, large multi-component complex, and preparation technology's difficulty is large, and doctor trained in Western medicine is usually based on operative treatment, dangerous large, costly; And the traditional Chinese medical science normally uses Drug therapy, be difficult to reach satisfied effect in treatment, and also easily recurrence after curing.
Summary of the invention
The invention provides a kind of medicine and preparation method for the treatment of chronic endometritis; Selected by medicine of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of YIN nourishing of enriching blood, promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, to treatment chronic endometritis, there is good effect, instant effect, short treating period, the advantage that has no side effect, and evident in efficacy, non-relapse after healing, safe and reliable, with low cost, should be widely promoted application.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a medicine for chronic endometritis, raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Treat a preparation method for the medicine of chronic endometritis, comprise following processing step:
(1) Semen Nelumbinis, Cortex Ailanthi, Herba Caraganae intermediae, lignum Ormosiae henryi, Folium Ilicis, Pollen Typhae, Herba Farfugii japonici, Spica Cannabis Tener and empty bucket are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(2) Viola grypoceras A. Gray is put into container, strand juice, adds Mel and stirs, and leaves standstill half an hour, then adds the distilled water of 3 times amount, stir, and filter impurity, stays juice for subsequent use;
(3) Semen Benincasae and Hibisci Mutabilis root are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(4) Celastrus gemmatus Loes. and ink seven to be cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaims ethanol, filters, obtains filtrate, for subsequent use;
(5) cleaned by Folium Aloe, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(6) Flos Solani Melongenae is put into pot, dry, taking-up cools, and grinds into powder, crosses 200 order fine powders, for subsequent use;
(7) by the thick paste obtained by above-mentioned steps (1) ~ (6), juice, fine powder and filtrate mixing, make capsule, obtain the medicine for the treatment of chronic endometritis of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Semen Nelumbinis: sweet in the mouth, puckery, property is put down; Return spleen, kidney, heart channel.Nourish heart, kidney tonifying, spleen reinforcing, astringing intestine to stop diarrhea.Control dreaminess of sleeping night, seminal emission, stranguria with turbid discharge, chronic dysentery, diarrhea of deficiency type, married woman's bleeding not during menses.Semen Caesalpiniae Minacis is energy preventing or arresting vomiting, appetizing also, commonly uses and controls fasting dysentery." detailed outline " carries: " kidney of laying one's heart bear, thick the intestines and stomach, controlling nocturnal emission with astringent drugs gas, bone and muscle strengthening, tonifying deficiency, sharp knowledge, eliminating cold-damp, only the splenic diarrhea chronic dysentery, reddish and whitish turbid urine, all disorders of blood of woman's leukorrhagia metrorrhagia.”
Cortex Ailanthi: bitter in the mouth, puckery, cold in nature; Return stomach, large intestine, the heart, liver, spleen, lung meridian.Heat clearing and damp drying, astringing intestine to stop diarrhea, hemostasis, leukorrhagia stopping, parasite killing.Cure mainly and have loose bowels, dysentery, have blood in stool, metrorrhagia, bleeding hemorrhoids, leukorrhagia, ascariasis, skin ulcer tinea." modern Practical Chinese medicinal " carries: " for oral administration control married woman's metrorrhagia and postpartum hemorrhage, metritis, enteritis, bloody dysentery, enterorrhagia, bladder and urinary tract inflammation, gonorrhea etc., have antiinflammatory, system is secreted, the merit of hemostasis; The illness of training the mind dysmenorrhoea and liver, spleen etc. again." modern medicine study confirm; Cortex Ailanthi decoct has obvious inhibitory action to shigella flexneri, S. sonnei and escherichia coli; contained ailanthinone and Ramulus Et Folium Picrasmae have antitumor action, be used for clinically treatment acute bacillary dysentery, amebic dysentery, have blood in stool, ulcer, ascariasis and cervical cancer.
Viola grypoceras A. Gray: mildly bitter flavor, cool in nature.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, cooling blood for hemostasis.Cure mainly carbuncle sore, pharyngitis, acute mastitis, acute conjunctivitis, knife injury is hemorrhage, and traumatic injury is had blood in stool, venom.
Herba Caraganae intermediae: sweet in the mouth, warm in nature; Return liver, kidney channel.Nourishing YIN and supplementing blood, invigorates blood circulation.Main menoxenia." soft science in China medicinal plants " carries: " nourishing YIN and benefiting blood.”
Semen Benincasae: sweet in the mouth, cold nature; Return lung, large intestine channel.Lung heat clearing, reduce phlegm, evacuation of pus.Be applicable to the diseases such as cough due to lung-heat, lung abscess, acute appendicitis." Shandong Chinese medicine " carries: " control nephritis, urethritis, dysuria, beriberi, edema.”
Lignum Ormosiae henryi: acrid in the mouth, warm in nature; Return liver, kidney channel.Expelling wind and removing dampness, promoting blood circulation and breaking stagnation, removing toxic substances and promoting subsidence of swelling.Main air wet arthritis, lumbar muscle strain, postnatal blood stasis is suffered from abdominal pain, multicoloured leukorrhagia, traumatic injury, fracture, flu, venom, innominate toxic swelling.Supplement to the Herbal carries: " main removing blood stasis, clot are coldly coughed, and liquor and decoction being taken hot.”
Hibisci Mutabilis root: acrid in the mouth, micro-hardship, cool in nature; GUIXIN, lung, Liver Channel.Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Cure mainly swollen ulcer drug from the beginning of, ecthyma, conjunctival congestion and swelling pain, lung abscess, cough with asthma, dysentery, married woman leucorrhea, pyelonephritis.
Folium Ilicis: sweet in the mouth, hardship, enters liver, lung, stomach warp.Loose wind heat, refresh oneself, relieving thirst and restlessness.Control headache, toothache, conjunctival congestion, Ting ear, calentura excessive thirst, dysentery." Chinese medicine voluminous dictionary " carries: " loose liver-wind, refresh oneself, controls tinnitus, deafness, Ting discharging ear, arteries and veins of invigorating blood circulation, cool uterus.”
Celastrus gemmatus Loes.: bitter in the mouth, pungent, property is put down; Return liver, stomach warp.Expelling wind and removing dampness, promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome, traumatic injury, menoxenia, amenorrhea, puerperal abdonimal pain, stomachache, colic, sore, carbuncle and painful swelling, fracture, rubella, eczema, herpes zoster, venom.
Pollen Typhae: sweet in the mouth, property is put down; Return liver, pericardium channel.Hemostasis, blood stasis dispelling, treating stranguria.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, blood strangury and dry pain." Japan hanako materia medica " carries: " controlling (top), to flutter blood vexed, evacuation of pus, furuncle, married woman's leukorrhagia, and the moon waits irregular, vim and vigour cardiac and abdominal pain; pregnant pregnant people's hematochezia fetal abortion, blood Yun mass resulting from the blood stasis, youngster rests the head on shoot, urinary obstruction, and hemorrhoidal hamorrhage rushes down blood; urticaria toxic swelling, and serious epistaxis is spitted blood, stimulating milk secretion, and stopping leak is smart, dysentery.Removing blood stasis detumescence is raw to be made, and tonifying blood and arresting bleeding is fried and used.”
Folium Aloe: bitter and puckery flavor, cold in nature; Pathogenic fire purging, stimulates the menstrual flow, parasite killing, removing toxic substances.Control nebulousurine, hematuria, women's amenorrhea, leukorrhagia, pediatric epilepsy scared, infantile malnutrition, scald, hemorrhoid, scabies, carbuncle." Nanning City's medicine will " carries: " disappear infantile malnutrition with fever, and parasite killing amasss, and stimulates the menstrual flow, cool liver.Control married woman's amenorrhea, pediatric epilepsy scared, infantile malnutrition.Life external application, controls burn and mumps.”
Flos Solani Melongenae: sweet in the mouth, property is put down.Sore, pain relieving, dampness removing.Chief creating is hindered, toothache, women's leukorrhagia.Compendium of Material Medica is carried: " control incised wound, toothache.”
Herba Farfugii japonici: acrid in the mouth, sweet, micro-hardship, cool in nature.Heat-clearing and toxic substances removing, cooling blood for hemostasis, dispersing swelling and dissipating binds.Main flu, laryngopharynx swelling and pain, cough spitting of blood, has blood in stool, hematuria, and friend is through uncomfortable, and mastitis, scrofula, carbuncle furuncle and phyma is malicious, carbuncle skin ulcer eczema, traumatic injury, venom." Zhejiang conventional medical herbs among the people " carries: " heat-clearing and toxic substances removing, reducing swelling and alleviating pain.”
Ink seven: acrid in the mouth, hardship, warm in nature, slightly poisonous.Promoting the circulation of QI to relieve pain, promoting blood flow to regulate menstruation.Cure mainly stomachache, menoxenia, traumatic injury, fracture such as to swell and ache the disease.
Spica Cannabis Tener: acrid in the mouth, property is put down, poisonous.Dispel the wind, pain relieving, spasmolytic.Control gout, arthromyodynia, demented, insomnia, cough with asthma." medicine figure examines " carries: " main anemia is dry coughs, and pacifies nerve, and only twitch, gout, arthromyodynia, sleeping, regulating menstruation removing blood stasis with potent drugs, uterus non-restoring, ovum adenalgia, demented, flirt, skin is itched.”
Herba Crepidis hookerianae: bitter in the mouth, micro-pungent, property is put down.Nourishing the lung to arrest cough, regulating menstruation, hemostasis, antiinflammatory, stimulating milk secretion.For cold cough, bronchitis, agalactia, mastitis, menoxenia, redly collapses, leucorrhea, epistaxis, furuncle carbuncle.
The present invention compared with prior art, has following beneficial effect:
Selected by medicine of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of YIN nourishing of enriching blood, promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, to treatment chronic endometritis, there is good effect, instant effect, short treating period, the advantage that has no side effect, and evident in efficacy, non-relapse after healing, safe and reliable, with low cost, should be widely promoted application.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of effective ingredient of the present invention and weight are:
Treat a preparation method for the medicine of chronic endometritis, comprise following processing step:
(1) Semen Nelumbinis, Cortex Ailanthi, Herba Caraganae intermediae, lignum Ormosiae henryi, Folium Ilicis, Pollen Typhae, Herba Farfugii japonici, Spica Cannabis Tener and Herba Crepidis hookerianae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(2) Viola grypoceras A. Gray is put into container, strand juice, adds Mel and stirs, and leaves standstill half an hour, then adds the distilled water of 3 times amount, stir, and filter impurity, stays juice for subsequent use;
(3) Semen Benincasae and Hibisci Mutabilis root are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(4) Celastrus gemmatus Loes. and ink seven to be cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaims ethanol, filters, obtains filtrate, for subsequent use;
(5) cleaned by Folium Aloe, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(6) Flos Solani Melongenae is put into pot, dry, taking-up cools, and grinds into powder, crosses 200 order fine powders, for subsequent use;
(7) by the thick paste obtained by above-mentioned steps (1) ~ (6), juice, fine powder and filtrate mixing, make capsule, obtain the medicine for the treatment of chronic endometritis of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 1 (every 0.5g), warm water delivery service after meal; Within 8 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the medicine for the treatment of chronic endometritis, select the routine clinical observation of chronic endometritis patient 130 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 65 example, 22 ~ 47 years old age, 34.5 years old mean age, average course of disease 2 years; Matched group 65 example, 21 ~ 46 years old age, 33.5 years old mean age, average course of disease 2 years.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes medicine of the present invention, oral, every day 2 times, each 1 time sooner or later, each 1 (every 0.5g), warm water delivery service after meal; Within 8 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes synestrin tablets, oral, and a 5mg (5), 3 times on the one, the course for the treatment of is depending on the state of an illness.
3, efficacy determination:
(1) cure: clinical symptoms all disappears, stomachache, lumbago disappear, and body index recovers normal on inspection.
(2) effective: clinical symptoms obviously alleviates, stomachache, lumbago obviously alleviate, and body index recovers normal substantially on inspection.
(3) effective: clinical symptoms alleviates to some extent, stomachache, lumbago alleviate to some extent, and body index part takes a turn for the better on inspection.
(4) invalid: unchanged by treating rear above-mentioned symptom.
4, result:
Select in the treatment group of medicine of the present invention, cure 32 examples, effective 21 examples, effective 10 examples, invalid 2 examples, cure rate 51.6%, total effective rate 96.9%.
24 examples are cured, effective 17 examples, effective 8 examples, invalid 16 examples, cure rate 36.9%, total effective rate 75.4% in matched group.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Cai, female, 23 years old, people from Jilin songyuan.Patient's lower abdomen dull pain is more than 1 year, remove examination in hospital, be diagnosed as chronic endometritis, after a period of time is treated in medication, have no any to alleviate, after take Drug therapy of the present invention, after taking 1 course for the treatment of, symptom obviously alleviates, after continuing to take 2 courses for the treatment of, symptom all disappears, recovery from illness, follows up a case by regular visits to without recurrence after 1 year.
2, certain is gone into business, female, 28 years old, Distributions in Liaocheng of Shandong Province people.Patient is because of lower abdomen dull pain and infertilely remove hospital admission, is diagnosed as chronic endometritis, and recommend to take Drug therapy of the present invention through doctor, after taking 1 course for the treatment of, symptom obviously alleviates, and after taking 2 courses for the treatment of, transference cure, recovery from illness, follows up a case by regular visits to so far without recurring.
3, fourth, female, 31 years old, Tongling, Anhui Province people.Patient feels to have a stomachache, and also feels the pain of lower abdomen tenesmus, removes hospital admission, be diagnosed as chronic endometritis, take Chinese medicine preparation of the present invention through doctor advised, after taking 1 course for the treatment of, pain symptom disappears substantially, after taking the 2nd course for the treatment of, transference cure, recovery from illness, follows up a case by regular visits to after half a year and does not recur.
4, Wei, female, 25 years old, Shanwei people.Patient carrys out outpatient clinic because of lower abdomen dull pain, checks and is shown as chronic endometritis, go the hospitalize of to too much home, also used many medicines, and loseed improvement.To our hospital afterwards, take Drug therapy of the present invention, symptom is clearly better, and after taking 3 courses for the treatment of of the present invention, transference cure, cures.
5, certain is shut out, female, 37 years old, changde, hunan people.The pain of patient's lower abdomen tenesmus, remove hospital admission, be diagnosed as chronic endometritis, through taking Drug therapy of the present invention, after taking 1 course for the treatment of, symptom takes a turn for the better to some extent, and after taking 1 course for the treatment of, symptom all disappears.
6, model, female, 39 years old, Hubei Xiaogan people.Patient at ordinary times often sense feels dizzy, distension and fullness in the abdomen, and weak breath asthenia, is diagnosed as chronic endometritis, takes Drug therapy of the present invention, every day 2 times, each 1 time sooner or later, each 2 (every 0.5g), warm water delivery service after meal; After taking 1 course for the treatment of, symptom takes a turn for the better to some extent, and after continuing to take 1 course for the treatment of, symptom all disappears, and follows up a case by regular visits to and have no recurrence after half a year.

Claims (5)

1. treat a medicine for chronic endometritis, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Semen Nelumbinis 28 ~ 52 parts of Cortex Ailanthis 26 ~ 50 parts of Viola grypoceras A. Grays 25 ~ 49 parts of Herba Caraganae intermediaes 23 ~ 47 parts
Semen Benincasae 21 ~ 45 parts of lignum Ormosiae henryi 19 ~ 43 parts of Hibisci Mutabilis roots 18 ~ 42 parts of Folium Ilicis 17 ~ 41 parts
Celastrus gemmatus Loes. 14 ~ 38 parts of Pollen Typhaes 13 ~ 37 parts of Folium Aloes 10 ~ 34 parts of Flos Solani Melongenaes 8 ~ 32 parts
Herba Farfugii japonici 6 ~ 30 parts of ink 74 ~ 27 parts of Spica Cannabis Tener 4 ~ 23 parts of Herba Crepidis hookerianae 1 ~ 19 part.
2. a kind of medicine for the treatment of chronic endometritis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Semen Nelumbinis 32 ~ 48 parts of Cortex Ailanthis 30 ~ 46 parts of Viola grypoceras A. Grays 29 ~ 45 parts of Herba Caraganae intermediaes 27 ~ 43 parts
Semen Benincasae 25 ~ 41 parts of lignum Ormosiae henryi 23 ~ 39 parts of Hibisci Mutabilis roots 22 ~ 38 parts of Folium Ilicis 21 ~ 37 parts
Celastrus gemmatus Loes. 18 ~ 34 parts of Pollen Typhaes 17 ~ 33 parts of Folium Aloes 14 ~ 30 parts of Flos Solani Melongenaes 12 ~ 28 parts
Herba Farfugii japonici 10 ~ 26 parts of ink 78 ~ 23 parts of Spica Cannabis Tener 7 ~ 19 parts of Herba Crepidis hookerianae 4 ~ 16 parts.
3. a kind of medicine for the treatment of chronic endometritis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Semen Nelumbinis 36 ~ 44 parts of Cortex Ailanthis 34 ~ 42 parts of Viola grypoceras A. Grays 33 ~ 41 parts of Herba Caraganae intermediaes 31 ~ 39 parts
Semen Benincasae 29 ~ 37 parts of lignum Ormosiae henryi 27 ~ 35 parts of Hibisci Mutabilis roots 26 ~ 34 parts of Folium Ilicis 25 ~ 33 parts
Celastrus gemmatus Loes. 22 ~ 30 parts of Pollen Typhaes 21 ~ 29 parts of Folium Aloes 18 ~ 26 parts of Flos Solani Melongenaes 16 ~ 24 parts
Herba Farfugii japonici 14 ~ 22 parts of ink 7 11 ~ 19 parts of Spica Cannabis Tener 10 ~ 16 parts of Herba Crepidis hookerianae 7 ~ 13 parts.
4. a kind of medicine for the treatment of chronic endometritis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Semen Nelumbinis 40 parts of Cortex Ailanthis 38 parts of Viola grypoceras A. Grays 37 parts of Herba Caraganae intermediaes 35 parts
Semen Benincasae 33 parts of lignum Ormosiae henryi 31 parts of Hibisci Mutabilis roots 30 parts of Folium Ilicis 29 parts
Celastrus gemmatus Loes. 26 parts of Pollen Typhaes 25 parts of Folium Aloes 22 parts of Flos Solani Melongenaes 20 parts
Herba Farfugii japonici 18 parts of ink 7 15 parts of Spica Cannabis Tener 13 parts of Herba Crepidis hookerianae 10 parts.
5. as described in any one of Claims 1 to 4, treat a preparation method for the medicine of chronic endometritis, it is characterized in that: comprise following processing step:
(1) Semen Nelumbinis, Cortex Ailanthi, Herba Caraganae intermediae, lignum Ormosiae henryi, Folium Ilicis, Pollen Typhae, Herba Farfugii japonici, Spica Cannabis Tener and Herba Crepidis hookerianae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(2) Viola grypoceras A. Gray is put into container, strand juice, adds Mel and stirs, and leaves standstill half an hour, then adds the distilled water of 3 times amount, stir, and filter impurity, stays juice for subsequent use;
(3) Semen Benincasae and Hibisci Mutabilis root are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(4) Celastrus gemmatus Loes. and ink seven to be cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaims ethanol, filters, obtains filtrate, for subsequent use;
(5) cleaned by Folium Aloe, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(6) Flos Solani Melongenae is put into pot, dry, taking-up cools, and grinds into powder, crosses 200 order fine powders, for subsequent use;
(7) by the thick paste obtained by above-mentioned steps (1) ~ (6), juice, fine powder and filtrate mixing, make capsule, obtain the medicine of described treatment chronic endometritis.
CN201410801839.5A 2014-12-19 2014-12-19 Medicine for treating chronic endometritis and preparation method of medicine Pending CN104435454A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104707124A (en) * 2015-04-03 2015-06-17 杜卫卫 Traditional Chinese medicine preparation for treating chronic endometritis
CN105250768A (en) * 2015-11-03 2016-01-20 肖淑辉 Traditional Chinese medicine for treating endometritis due to yin-deficiency with stasis and preparation method thereof
CN105434868A (en) * 2015-12-22 2016-03-30 盛庆石 Preparation used for treating chronic endometritis, and preparation method thereof
RU2701148C1 (en) * 2018-10-01 2019-09-25 Общество с ограниченной ответственностью "Клиника профессора Пасман" (ООО "Клиника профессора Пасман") Method of chronic endometritis treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129923A (en) * 2007-09-24 2008-02-27 北京艺信堂医药研究所 Traditional Chinese medicine preparation for treating endometritis
CN103071093A (en) * 2013-01-17 2013-05-01 遵义县南白镇华南药房 Medicine for treating gynecological diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129923A (en) * 2007-09-24 2008-02-27 北京艺信堂医药研究所 Traditional Chinese medicine preparation for treating endometritis
CN103071093A (en) * 2013-01-17 2013-05-01 遵义县南白镇华南药房 Medicine for treating gynecological diseases

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104707124A (en) * 2015-04-03 2015-06-17 杜卫卫 Traditional Chinese medicine preparation for treating chronic endometritis
CN105250768A (en) * 2015-11-03 2016-01-20 肖淑辉 Traditional Chinese medicine for treating endometritis due to yin-deficiency with stasis and preparation method thereof
CN105434868A (en) * 2015-12-22 2016-03-30 盛庆石 Preparation used for treating chronic endometritis, and preparation method thereof
RU2701148C1 (en) * 2018-10-01 2019-09-25 Общество с ограниченной ответственностью "Клиника профессора Пасман" (ООО "Клиника профессора Пасман") Method of chronic endometritis treatment

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