CN103041160A - Traditional Chinese medicine composition for curing acute pharyngitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for curing acute pharyngitis and preparation method thereof Download PDFInfo
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for curing acute pharyngitis. Bulk drugs of the traditional Chinese medicine composition include herb of glabrous sarcandra, polygonum cuspidatum, rhizoma acori graminei, Chinese mahonia stems, scaphium scaphigerum, scutellaria baicalensis, periostracum cicada, dioscorea panthaica prain et burk, radix asteris, flos sophorae, gallnut, fructus gleditsiae, solidago virgaurea, indigo naturalis, ephedra, rhizoma panacis majoris, radix polygonati officinalis, sea-buckthorn, myrobalan, radix scrophulariae, kadsura pepper stems, panax japonicus, puffball, adenophora tetraphylla, Chinese yam, wadalee-gum-tree and liquorice. The traditional Chinese medicine composition can not only control the symptom of acute pharyngitis, but also adjust the equilibrium between yin and yang, improve immunity of human bodies to improve the purposes of nourishing, nursing, relieving symptom, protecting and solidifying the body, and has the advantages of no toxic and side effect, no drug resistance, good curative effect, quickness of becoming effective, no damage to human bodies, and no recurrence of illness after treatment compared with the western medicine for curing acute pharyngitis.
Description
Technical field
The present invention relates to the Chinese medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of acute pharyngitis and preparation method thereof.
Background technology
Pharynx is one of organ of wanting of body weight for humans, is human body and the extraneous thoroughfare that communicates.When throat is subjected to antibacterial and viral infection, just causes easily upper respiratory tract infection and infect.Pharyngitis namely is to be assembled by the inflammation of the pharyngeal mucosa of upper respiratory tract infection initiation and submucous tissue thereof.Pharyngitis can be divided into according to the length of the course of disease and the difference of pathomorphology character: acute pharyngitis and chronic pharyngitis.
Acute pharyngitis (acute pharyngitis): be pharyngeal mucosa, submucous tissue and adenoid acute inflammation thereof, it is the part of clinical common upper respiratory tract actute infection, be commonly encountered diseases, the frequently-occurring disease of hals,Nasen und Ohrenheilkunde, sickness rate is high, accounts for otorhinolaryngologic 2%～6%, account for 7%～17% of larynx section, complication is many, can cause measles, influenza, scarlet fever etc., can occur separately, also can be caused by acute rhinitis or acute tonsillitis, mostly occur in the replacement of autumn and winter or Winter-Spring.Often because of flu, overfatigue is subjected to the stimulations such as chemical gas, dust to acute pharyngitis for a long time, or because of impacts such as sinusitis, Abwehrkraft des Koepers reduces, and it is pathogenic that antibacterial or virus are taken advantage of a weak point, if the prolonged and repeated outbreak of acute pharyngitis can cause the chronic pharyngitis that is difficult to cure.
The pathological change that acute pharyngitis can cause, not only can cause pharyngeal pathological changes, also can involve other contiguous organs, it is involved, even affecting other functions of body, present stage has more and more had influence on human health status and normal work, life.
Modern medicine mostly adopts antibiotics or is aided with the hormones preparation such as dexamethasone, and antiviral drugs, the treatment acute pharyngitis.But treatment spectrum is narrow, easily repeatedly outbreak, toleration are poor, large, the common pathogenic microorganism of toxic and side effects reaction produces drug resistance, drug combination to medicine mutual cross action occurs easily, affects the health giving quality of patient dependence and medicine.
Compare with modern medicine, it is little that the traditional Chinese medical science has toxic and side effects in treatment aspect the disease, and effect is lasting, and the characteristics such as treating both the principal and secondary aspects of a disease have a large amount of experiences aspect the treatment acute pharyngitis.Acute pharyngitis belongs to " acute inflammation of the throat " category in motherland's medical science, how because of wind-heat evil toxin invasion and attack throat, internal injury is fought mutually and do not gone in lung, causes the swelling throat plug and arthralgia pain; Or pathogenic heat heap soil or fertilizer over and around the roots Sheng, to be defended in the biography by lung, pathogenic heat is followed through the throat of burning, make laryngopharynx swelling and pain form sore throat, primary disease is to have sore throat, red swelling of the pharynx, at the bottom of the larynx or the granule projection is arranged, pharyngeal tonsils swelling is not obvious, and it is the pharyngeal acute inflammation of main clinical manifestation that whole body has the wind heat symptom.
Traditional chinese medicine medicament treatment acute pharyngitis not only can be controlled the surface symptoms of acute pharyngitis take treating both the principal and secondary aspects of a disease as principle, can also regulate equilibrium between yin and yang, strengthens body immunity, reaches nourishing, conditioning, relief of symptoms, holds up this solid positive purpose.
The present invention is exactly take theory of Chinese medical science as the basis, proposes a kind of Chinese medicine composition that is used for the treatment of acute pharyngitis, not only can control the symptom of acute pharyngitis, can also regulate equilibrium between yin and yang, strengthen body immunity, reach nourishing, conditioning, relief of symptoms, hold up this solid positive purpose, with respect to the western medicine acute pharyngitis, this Chinese medicine composition has no side effect, have no drug resistance good effect, instant effect, to the human zero damage, the state of an illness is not repeatedly after the treatment.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine composition that is used for the treatment of acute pharyngitis is provided, and not only can control the symptom of acute pharyngitis, can also regulate equilibrium between yin and yang, strengthen body immunity, reach nourishing, conditioning, relief of symptoms, hold up this solid positive purpose, with respect to the western medicine acute pharyngitis, this Chinese medicine composition has no side effect, have no drug resistance good effect, instant effect, to the human zero damage, the state of an illness is not repeatedly after the treatment.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of acute pharyngitis, its crude drug comprises: Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae.
Wherein, the weight portion of each crude drug is respectively Herba Sarcandrae 42 weight portions ~ 52 weight portions in the described Chinese medicine composition, Rhizoma Polygoni Cuspidati 46 weight portions ~ 56 weight portions, Rhizoma Acori Graminei 23 weight portions ~ 33 weight portions, Caulis Mahoniae 34 weight portions ~ 44 weight portions, Semen Sterculiae Lychnophorae 29 weight portions ~ 39 weight portions, Radix Scutellariae 77 weight portions ~ 87 weight portions, Periostracum Cicadae 16 weight portions ~ 26 weight portions, Dioscorea panthaica Prain et Burkill 42 weight portions ~ 52 weight portions, Radix Asteris 26 weight portions ~ 36 weight portions, Flos Sophorae 13 weight portions ~ 23 weight portions, Galla Chinensis 39 weight portions ~ 49 weight portions, Fructus Gleditsiae Abnormalis 22 weight portions ~ 32 weight portions, Herba Solidaginis 25 weight portions ~ 35 weight portions, Indigo Naturalis 61 weight portions ~ 71 weight portions, Herba Ephedrae 30 weight portions ~ 40 weight portions, Rhizoma Panacis Majoris 39 weight portions ~ 49 weight portions, Rhizoma Polygonati Odorati 18 weight portions ~ 28 weight portions, Fructus Hippophae 26 weight portions ~ 36 weight portions, Fructus Chebulae's 20 weight portions ~ 30 weight portions, Radix Scrophulariae 27 weight portions ~ 37 weight portions, Caulis Piperis Kadsurae 35 weight portions ~ 45 weight portions, Rhizoma Panacis Japonici 30 weight portions ~ 40 weight portions, Lasiosphaera Seu Calvatia 16 weight portions ~ 26 weight portions, Radix Adenophorae 31 weight portions ~ 41 weight portions, Rhizoma Dioscoreae 39 weight portions ~ 49 weight portions, catechu 19 weight portions ~ 29 weight portions and Radix Glycyrrhizae 26 weight portions ~ 36 weight portions.
Wherein, the weight portion of each crude drug is respectively Herba Sarcandrae 45 weight portions ~ 49 weight portions in the described Chinese medicine composition, Rhizoma Polygoni Cuspidati 49 weight portions ~ 53 weight portions, Rhizoma Acori Graminei 26 weight portions ~ 30 weight portions, Caulis Mahoniae 37 weight portions ~ 41 weight portions, Semen Sterculiae Lychnophorae 32 weight portions ~ 36 weight portions, Radix Scutellariae 80 weight portions ~ 84 weight portions, Periostracum Cicadae 19 weight portions ~ 23 weight portions, Dioscorea panthaica Prain et Burkill 45 weight portions ~ 49 weight portions, Radix Asteris 29 weight portions ~ 33 weight portions, Flos Sophorae 16 weight portions ~ 20 weight portions, Galla Chinensis 42 weight portions ~ 46 weight portions, Fructus Gleditsiae Abnormalis 25 weight portions ~ 29 weight portions, Herba Solidaginis 28 weight portions ~ 32 weight portions, Indigo Naturalis 64 weight portions ~ 68 weight portions, Herba Ephedrae 33 weight portions ~ 37 weight portions, Rhizoma Panacis Majoris 42 weight portions ~ 46 weight portions, Rhizoma Polygonati Odorati 21 weight portions ~ 25 weight portions, Fructus Hippophae 29 weight portions ~ 33 weight portions, Fructus Chebulae's 23 weight portions ~ 27 weight portions, Radix Scrophulariae 30 weight portions ~ 34 weight portions, Caulis Piperis Kadsurae 38 weight portions ~ 42 weight portions, Rhizoma Panacis Japonici 33 weight portions ~ 37 weight portions, Lasiosphaera Seu Calvatia 19 weight portions ~ 23 weight portions, Radix Adenophorae 34 weight portions ~ 38 weight portions, Rhizoma Dioscoreae 42 weight portions ~ 46 weight portions, catechu 22 weight portions ~ 26 weight portions and Radix Glycyrrhizae 29 weight portions ~ 33 weight portions.
Wherein, the weight portion of each crude drug is respectively Herba Sarcandrae 47 weight portions in the described Chinese medicine composition, Rhizoma Polygoni Cuspidati 51 weight portions, Rhizoma Acori Graminei 28 weight portions, Caulis Mahoniae 39 weight portions, Semen Sterculiae Lychnophorae 34 weight portions, Radix Scutellariae 82 weight portions, Periostracum Cicadae 21 weight portions, Dioscorea panthaica Prain et Burkill 47 weight portions, Radix Asteris 31 weight portions, Flos Sophorae 18 weight portions, Galla Chinensis 44 weight portions, Fructus Gleditsiae Abnormalis 27 weight portions, Herba Solidaginis 30 weight portions, Indigo Naturalis 66 weight portions, Herba Ephedrae 35 weight portions, Rhizoma Panacis Majoris 44 weight portions, Rhizoma Polygonati Odorati 23 weight portions, Fructus Hippophae 31 weight portions, Fructus Chebulae's 25 weight portions, Radix Scrophulariae 32 weight portions, Caulis Piperis Kadsurae 40 weight portions, Rhizoma Panacis Japonici 35 weight portions, Lasiosphaera Seu Calvatia 21 weight portions, Radix Adenophorae 36 weight portions, Rhizoma Dioscoreae 44 weight portions, catechu 24 weight portions and Radix Glycyrrhizae 31 weight portions.
Wherein, the dosage form of described Chinese medicine composition is tablet, soft capsule, powder, granule, pill, mixture.
The present invention also provide above-mentioned Chinese medicine composition for the preparation of the treatment acute pharyngitis medicine in application.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is granule, is specially:
The first step, described each crude drug component sent in the mixing and blending machine mix, then pour in the multi-function extractor, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, and temperature is controlled at 98 ~ 102 ℃, again obtains extracting solution, extracting solution is merged, obtain total extracting solution;
Second step, the pH value of regulating total extracting solution with hydrochloric acid is 5 ~ 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, and the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2 ~ 3:1, and at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 5 ~ 7 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing obtains and gets dry extract, be ground into fine powder, spray drying;
In the 3rd step, in dried fine powder, add corn dextrin and cane sugar powder, mixing, granulate, splitting and filling is with respect to the dried cream powder of 100 weight portions, the addition of corn dextrin is 80 weight portions ~ 120 weight portions, and the addition of cane sugar powder is 300 weight portions ~ 400 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is tablet, is specially:
The first step, described each crude drug component sent in the mixing and blending machine mix, then pour in the multi-function extractor, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, and temperature is controlled at 98 ~ 102 ℃, again obtains extracting solution, extracting solution is merged, obtain total extracting solution;
Second step, the pH value of regulating total extracting solution with hydrochloric acid is 5 ~ 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, and the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2 ~ 3:1, and at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 5 ~ 7 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing obtains and gets dry extract, be ground into fine powder, spray drying;
The 3rd step, behind the sodium carboxymethyl cellulose of fine powder 100 weight portions that spray drying is obtained and the polyvinylpyrrolidone of 60～100 weight portions, 30～50 weight portions, the microcrystalline Cellulose mixing of 120～180 weight portions, determining alcohol with 20～30 weight portions is that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 45 ℃～50 ℃ temperature ranges, with 16 mesh sieve granulate, and after adding the micropowder silica gel of the magnesium stearate of 7～9 weight portions and 6～8 weight portions, material is pressed into medicinal dispersing tablets.
The present invention also provides a kind of Chinese medicinal composition granules that is used for the treatment of acute pharyngitis, its crude drug comprises: Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae
The preparation method of described granule is specially,
The first step, described each crude drug component sent in the mixing and blending machine mix, then pour in the multi-function extractor, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, and temperature is controlled at 98 ~ 102 ℃, again obtains extracting solution, extracting solution is merged, obtain total extracting solution;
Second step, the pH value of regulating total extracting solution with hydrochloric acid is 5 ~ 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, and the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2 ~ 3:1, and at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 5 ~ 7 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing obtains and gets dry extract, be ground into fine powder, spray drying;
In the 3rd step, in dried fine powder, add corn dextrin and cane sugar powder, mixing, granulate, splitting and filling is with respect to the dried cream powder of 100 weight portions, the addition of corn dextrin is 80 weight portions ~ 120 weight portions, and the addition of cane sugar powder is 300 weight portions ~ 400 weight portions.
The present invention also provides a kind of Chinese medicine composition tablet that is used for the treatment of acute pharyngitis, its crude drug comprises: Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae
The preparation method of described tablet is specially,
The first step, described each crude drug component sent in the mixing and blending machine mix, then pour in the multi-function extractor, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, and temperature is controlled at 98 ~ 102 ℃, again obtains extracting solution, extracting solution is merged, obtain total extracting solution;
Second step, the pH value of regulating total extracting solution with hydrochloric acid is 5 ~ 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, and the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2 ~ 3:1, and at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 5 ~ 7 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing obtains and gets dry extract, be ground into fine powder, spray drying;
The 3rd step, behind the sodium carboxymethyl cellulose of fine powder 100 weight portions that spray drying is obtained and the polyvinylpyrrolidone of 60～100 weight portions, 30～50 weight portions, the microcrystalline Cellulose mixing of 120～180 weight portions, determining alcohol with 20～30 weight portions is that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 45 ℃～50 ℃ temperature ranges, with 16 mesh sieve granulate, and after adding the micropowder silica gel of the magnesium stearate of 7～9 weight portions and 6～8 weight portions, material is pressed into medicinal dispersing tablets.
Beneficial effect of the present invention:
The Chinese medicine composition that is used for the treatment of acute pharyngitis provided by the invention, not only can control the symptom of acute pharyngitis, can also regulate equilibrium between yin and yang, strengthen body immunity, reach nourishing, conditioning, relief of symptoms, hold up this solid positive order, with respect to the western medicine acute pharyngitis, this Chinese medicine composition has no side effect, and has no drug resistance, good effect, instant effect, to the human zero damage, the state of an illness is not repeatedly after the treatment.
The specific embodiment
Acute pharyngitis belongs to the traditional Chinese medical science " acute inflammation of the throat " category, be because of the exopathogen visitor due to pharyngeal, the heresy of the not outer wind and cold of exopathogen and wind heat, and the easily strongly fragrant and heat-transformation of the heresy of wind and cold, so clinical common with wind-heat syndrome, so be called again " acute pharyngitis due to wind-heat ", motherland's medical science has again saying of " throat disease all belonging to fire ", and its sick position is at pharynx and lung.In close relations with stomach, the cause of disease is main mainly with " wind heat poison ", and heat syndrome is in the majority, cold person seldom, and strongly fragrant and factors such as heat-transformation of wind-cold tightening the lung.Acute pharyngitis mostly is the heresy of experiencing wind heat, lung defend lose solid, exopathogen in the throat with the QI and blood knot of fighting mutually, or wind-cold affecting lung, exopathogen is not understood, the strongly fragrant and heat-transformation of cold-evil, tie in throat, or exuberant lung-stomach heat, on steam in throat and pharyngalgia, silent, dysphagia occur, red swelling of the pharynx, dryness and heat sense or itch and cough, or cough expectorant is yellow, heating, constipation with dry stool, yellow urine, red tongue, yellow and greasy fur, full and rapid pulse etc.
" a Plain Questions negative and positive another matter piece of writing " cloud " monoyin and monoyang knot, the sore throat of meaning ", and " former sick formula six gas of Plain Questions arcane truth are the fiery class sore throat of disease " is interpreted as: " also meciless, custom is closed for sore throat, numbness, and still obturation is also ".Be that primary disease is because interior exopathogen poison knot is poly-, and cause qi depression to blood stasis, due to the BI-syndrome involved the blood vessels resistance, burning hot heresy can be accelerated again the operation of blood simultaneously, and the venation of burning is overflow hot forcing blood, and blood is from through forming the stasis of blood, so " stasis of blood " the individual main pathogenesis that is one.Say as far back as " Medical Treasures of the Golden Chamber ": " heat is mistake for it, stagnation of blood ", " Shengji Zonglu typhoid fever system opinion " also has the opinion of " stasis of blood then became blood stasis in poison was evil ".Further investigation according to modern blood stasis symptom, recognize and in acute inflammation of the throat, exist local infection body tissue dissolving (suppuration), capillary permeability strengthens, the Local residues Denatured protein, the pathogenesis of blood stasis such as tissue fibering pass through blood circulation promoting and blood stasis dispelling in the treatment, accelerate velocity of blood flow and eliminate stasis of blood stream, improve the blood circulation of local organization, promote the absorption of inflammatory exudate, alleviate or eliminate the symptoms such as pharyngeal congestion, edema.
According to above-mentioned theory of Chinese medical science, the present invention is take wind and heat dispersing, lung qi dispersing sore-throat relieving, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting as the Therapeutic Principle, a kind of oral traditional Chinese medicine composition that is used for the treatment of acute pharyngitis is provided, and it comprises following crude drug: Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae.
Preferably, described oral traditional Chinese medicine composition only is made of the above-mentioned raw materials medicine.
In the side, Herba Sarcandrae, the Dioscorea panthaica Prain et Burkill heat-clearing and toxic substances removing, anti-inflammation detumescence, the clear eliminating the pathogens from the lung heat of Rhizoma Polygoni Cuspidati, expelling phlegm for arresting cough, the dissipating blood stasis analgesic therapy, Rhizoma Acori Graminei is had one's ideas straightened out loose evil, clearing away heat to alleviate pain, expelling pathogenic factors from the exterior is gone out with sore-throat relieving, Caulis Mahoniae, Indigo Naturalis has anticoagulant, improve immunity of organism, protect the liver, function of gallbladder promoting, promote the effect of bile secretion, Semen Sterculiae Lychnophorae rushes down lower, blood pressure lowering, diuresis, analgesia, vascular smooth muscle there is contraction, can improve mucosal inflammation and alleviate spasmic pain, the Periostracum Cicadae relieving sore throat to recover voice, Radix Asteris nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm, the heat clearing away sophora pathogenic fire purging, the eliminating stagnation throat, expelling pathogenic factors from the exterior is gone out, be applicable to the card of laryngopharynx swelling and pain due to the evil poison of diseases caused by exogenous pathogenic factor, Fructus Gleditsiae Abnormalis is to the position, oral cavity, the direct stimulation of gastric mucosa, reflexive ground increases the bronchial mucosa hypersecretion, thereby makes the sputum dilution, is easy to discharge and an antitussive effect, Herba Solidaginis, Indigo Naturalis, Rhizoma Polygoni Cuspidati, Radix Scutellariae has the various pathogens such as anti-mycobacterium tuberculosis certain inhibitory action is all arranged, to Multiple Classes of Antibiotics, the inflammation local vascular is shunk, alleviate its inflammatory reaction, Herba Ephedrae lung qi dispersing table and relievining asthma, cough-relieving sea-buckthorn eliminates the phlegm, promoting blood circulation to remove blood stasis, Fructus Chebulae's sore-throat relieving clearing away lung-heat to relieve cough, Radix Scrophulariae nourishing YIN to lower pathogenic fire, clearing away heat and cooling blood, the eliminating stagnation sore-throat relieving, the Caulis Piperis Kadsurae expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, the loose blood of the clear part of the body cavity above the diaphragm housing the heart and lungs lung-heat of Lasiosphaera Seu Calvatia and liyan jiedu, the Rhizoma Panacis Japonici expelling phlegm for arresting cough, dissipating blood stasis for subsidence of swelling, the Radix Adenophorae replenishing YIN and removing heat, moistening the lung and resolving phlegm, the Rhizoma Polygonati Odorati nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the yin nourishing of Rhizoma Panacis Majoris tonifying the lung, dissipating blood stasis hemostasis, the Galla Chinensis pathogenic fire reducing of astringing the lung, the detoxifcation sore, the catechu removing toxic substances and promoting granulation, the dehumidifying dysentery relieving, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, each crude drug is united use, realizes wind and heat dispersing, the lung qi dispersing sore-throat relieving, blood circulation promoting and blood stasis dispelling, the effect of putrefaction-removing granulation-promoting.
Pharmacological research shows; Chinese medicine composition provided by the invention all has stronger anti-microbial property to the blue coccus of most leather, bacillus; can reduce capillary permeability; the effects such as certain functions of detumescence, relieving inflammation, antiviral, analgesia, the recovery of promotion mucosal epithelium are arranged; can protect or the raising body's immunity, thereby can strengthen the effect of leading pyretic toxicity, detumescence switching off, can eliminate rapidly pharyngeal swelling and ache; reach the pharyngeal mucosa reparation, the purpose of rehabilitation.
Each raw material medicines in portions by weight is respectively in the described Chinese medicine composition:
Herba Sarcandrae 42 weight portions ~ 52 weight portions, Rhizoma Polygoni Cuspidati 46 weight portions ~ 56 weight portions, Rhizoma Acori Graminei 23 weight portions ~ 33 weight portions, Caulis Mahoniae 34 weight portions ~ 44 weight portions, Semen Sterculiae Lychnophorae 29 weight portions ~ 39 weight portions, Radix Scutellariae 77 weight portions ~ 87 weight portions, Periostracum Cicadae 16 weight portions ~ 26 weight portions, Dioscorea panthaica Prain et Burkill 42 weight portions ~ 52 weight portions, Radix Asteris 26 weight portions ~ 36 weight portions, Flos Sophorae 13 weight portions ~ 23 weight portions, Galla Chinensis 39 weight portions ~ 49 weight portions, Fructus Gleditsiae Abnormalis 22 weight portions ~ 32 weight portions, Herba Solidaginis 25 weight portions ~ 35 weight portions, Indigo Naturalis 61 weight portions ~ 71 weight portions, Herba Ephedrae 30 weight portions ~ 40 weight portions, Rhizoma Panacis Majoris 39 weight portions ~ 49 weight portions, Rhizoma Polygonati Odorati 18 weight portions ~ 28 weight portions, Fructus Hippophae 26 weight portions ~ 36 weight portions, Fructus Chebulae's 20 weight portions ~ 30 weight portions, Radix Scrophulariae 27 weight portions ~ 37 weight portions, Caulis Piperis Kadsurae 35 weight portions ~ 45 weight portions, Rhizoma Panacis Japonici 30 weight portions ~ 40 weight portions, Lasiosphaera Seu Calvatia 16 weight portions ~ 26 weight portions, Radix Adenophorae 31 weight portions ~ 41 weight portions, Rhizoma Dioscoreae 39 weight portions ~ 49 weight portions, catechu 19 weight portions ~ 29 weight portions and Radix Glycyrrhizae 26 weight portions ~ 36 weight portions.
The weight portion of each crude drug further preferably is respectively in the described Chinese medicine composition:
Herba Sarcandrae 45 weight portions ~ 49 weight portions, Rhizoma Polygoni Cuspidati 49 weight portions ~ 53 weight portions, Rhizoma Acori Graminei 26 weight portions ~ 30 weight portions, Caulis Mahoniae 37 weight portions ~ 41 weight portions, Semen Sterculiae Lychnophorae 32 weight portions ~ 36 weight portions, Radix Scutellariae 80 weight portions ~ 84 weight portions, Periostracum Cicadae 19 weight portions ~ 23 weight portions, Dioscorea panthaica Prain et Burkill 45 weight portions ~ 49 weight portions, Radix Asteris 29 weight portions ~ 33 weight portions, Flos Sophorae 16 weight portions ~ 20 weight portions, Galla Chinensis 42 weight portions ~ 46 weight portions, Fructus Gleditsiae Abnormalis 25 weight portions ~ 29 weight portions, Herba Solidaginis 28 weight portions ~ 32 weight portions, Indigo Naturalis 64 weight portions ~ 68 weight portions, Herba Ephedrae 33 weight portions ~ 37 weight portions, Rhizoma Panacis Majoris 42 weight portions ~ 46 weight portions, Rhizoma Polygonati Odorati 21 weight portions ~ 25 weight portions, Fructus Hippophae 29 weight portions ~ 33 weight portions, Fructus Chebulae's 23 weight portions ~ 27 weight portions, Radix Scrophulariae 30 weight portions ~ 34 weight portions, Caulis Piperis Kadsurae 38 weight portions ~ 42 weight portions, Rhizoma Panacis Japonici 33 weight portions ~ 37 weight portions, Lasiosphaera Seu Calvatia 19 weight portions ~ 23 weight portions, Radix Adenophorae 34 weight portions ~ 38 weight portions, Rhizoma Dioscoreae 42 weight portions ~ 46 weight portions, catechu 22 weight portions ~ 26 weight portions and Radix Glycyrrhizae 29 weight portions ~ 33 weight portions.
The weight portion of each crude drug most preferably is respectively in the described Chinese medicine composition:
Herba Sarcandrae 47 weight portions, Rhizoma Polygoni Cuspidati 51 weight portions, Rhizoma Acori Graminei 28 weight portions, Caulis Mahoniae 39 weight portions, Semen Sterculiae Lychnophorae 34 weight portions, Radix Scutellariae 82 weight portions, Periostracum Cicadae 21 weight portions, Dioscorea panthaica Prain et Burkill 47 weight portions, Radix Asteris 31 weight portions, Flos Sophorae 18 weight portions, Galla Chinensis 44 weight portions, Fructus Gleditsiae Abnormalis 27 weight portions, Herba Solidaginis 30 weight portions, Indigo Naturalis 66 weight portions, Herba Ephedrae 35 weight portions, Rhizoma Panacis Majoris 44 weight portions, Rhizoma Polygonati Odorati 23 weight portions, Fructus Hippophae 31 weight portions, Fructus Chebulae's 25 weight portions, Radix Scrophulariae 32 weight portions, Caulis Piperis Kadsurae 40 weight portions, Rhizoma Panacis Japonici 35 weight portions, Lasiosphaera Seu Calvatia 21 weight portions, Radix Adenophorae 36 weight portions, Rhizoma Dioscoreae 44 weight portions, catechu 24 weight portions and Radix Glycyrrhizae 31 weight portions.
The pharmacology of each crude drug is as follows:
Herba Sarcandrae: latin name Sarcandrae Herba, slightly warm in nature, bitter in the mouth, suffering have anti-inflammation, dispelling wind and removing obstruction in the collateral, the effect of blood circulation promoting and dispersing pathogen accumulation cures mainly the cards such as pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor.
Rhizoma Polygoni Cuspidati: latin name Polygoni Cuspidati Rhizoma etRadix, little hardship is slightly cold.Return liver, gallbladder, lung meridian, have heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, the dissipating blood stasis analgesic therapy, the effect of relieving cough and resolving phlegm is used for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, the cards such as carbuncle sore tumefacting virus.
Rhizoma Acori Graminei: acrid in the mouth, warm in nature, enter the heart, the stomach warp has the refreshment of having one's ideas straightened out, and the effect of removing dampness to restore normal function of the stomach is used for the treatment of expectorant and covers clear key, and coma is demented, dizziness, insomnia, forgetful, tinnitus, retention of dampness in middle-JIAO, the cards such as abdominal distention.
Caulis Mahoniae: bitter in the mouth, cold in nature, return large intestine, kidney, lung meridian, have the effect of heat clearing away, dampness, detoxifcation, cure mainly the cough due to lung-heat, jaundice is had loose bowels, dysentery, conjunctival congestion and swelling pain, skin infection, eczema, the cards such as scald.
Semen Sterculiae Lychnophorae: sweet in the mouth, light, cool in nature, return lung, large intestine channel, have clearing heat and moistening lung, liyan jiedu, the effect of loosening bowel to relieve constipation cures mainly the lung-heat celostomia, dry cough without phlegm, pharyngodynia with dryness, accumulation of heat just closes, the effect of headache conjunctival congestion.
Radix Scutellariae: latin name Scutellariae Radix, bitter in the mouth, cold in nature enters the heart, lung, stomach, gallbladder, large intestine channel, and heat clearing and damp drying is arranged, and eliminating fire and detoxication is antiabortive, and the effect of hemostasis is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; The cough due to lung-heat, thirsty pharyngalgia also can be used for excessive fetal movement due to heat in pregnancy, and the pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.
Periostracum Cicadae: latin name Cicadae Periostracum, sweet in the mouth, lung, the Liver Channel of returning cold in nature, has a surname's wind heat extraction, rash, sore-throat relieving, the effect of spasmolytic, cure mainly affection due to external wind and heat or epidemic febrile disease from the beginning of due to heating, cough, pharyngalgia, pharynx mute, measles is sent out not smooth thoroughly, the rubella pruritus, wind-heat of liver channel, the cards such as the many tears of conjunctival congestion.
Dioscorea panthaica Prain et Burkill: latin name Dioscorea Panthaicae Rhizoma, sweet in the mouth, little suffering, property is flat, returns stomach, heart channel, has regulating QI to relieve pain, and the effect of removing toxic substances and promoting subsidence of swelling cures mainly stomachache, vomits and diarrhoea and suffer from abdominal pain, traumatic injury, the cards such as tuberculous lymphadenitis are controlled in external.
Radix Asteris: bitter in the mouth, sweet, slightly warm in nature enters lung meridian, have dredging lung meridian QI and blood, nourishing the lung to keep the adverse QI downward, the effect of relieving cough and resolving phlegm is mainly used in various cough with dyspnea, expectoration is not well, the cards such as sputum mixed with blood, the cough with dyspnea of especially applicable lung qi stasis, the visitor prevents and treats the hemoptysis vomiting pus of lung abscess, exogenous cough, no matter wind and cold wind heat, all applicable, Radix Asteris can increase bronchial secretion, in order to expectoration, and the effect of antitussive is arranged.
Flos Sophorae: bitter in the mouth, cold nature, return liver, large intestine channel, have cooling blood for hemostasis, the effect of purging liver-fire; Cure mainly discharging fresh blood stool, hemorrhoidal bleeding, dysentery, hematuria, stranguria with blood, metrorrhagia is spitted blood, epistaxis, liver-fire headache, conjunctival congestion and swelling pain, sore throat, aphonia, the cards such as ulcer sores.
Galla Chinensis: latin name GallaChinensis, sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, have the effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; The chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; The cards such as carbuncle furuncle, Galla Chinensis energy enhancing body can strengthen the immunologic function of cell to the defence capability of nonspecific stimulation, and this pathogenic bacterium are had inhibitory action, and can the antiviral growth.
Fructus Gleditsiae Abnormalis: acrid in the mouth, salty, warm in nature, slightly poisonous, enter lung, stomach, large intestine channel, having eliminates the phlegm has one's ideas straightened out, and the effect of mass dissipating and swelling eliminating cures mainly the apoplexy locked mouth, wind syndrome of head, wind is chronic, sore throat, phlegm dyspnea, feeling of fullness is stagnant, and obstruction and rejection is obstructed, carbuncle, mange, tinea disease, head sore.
Herba Solidaginis: latin name Solidaginis Herba, acrid in the mouth, hardship, cool in nature, return lung, Liver Channel, have the effect of heat-clearing and toxic substances removing, dispelling wind and heat pathogens, cure mainly the cards such as sore throat, laryngopharynx swelling and pain, anemopyretic cold.
Indigo Naturalis: salty in the mouth, cold in nature, enter Liver Channel, effect with heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire, be used for epidemic febrile disease and send out the cards such as all cards of pyretic toxicity such as speckle, haematemesis, laryngopharynx swelling and pain, herpes eczema, liver-fire invading the lung, cough chest pain, sputum mixed with blood, high hot infantile convulsion, convulsion with spasms, indigo, indirubin that Indigo Naturalis contains has heat-clearing and toxic substances removing, the antiviral effect of sore, and is inhibited to cholera bacilli, Bacillus typhi, dysentery bacterium and part virus.
Herba Ephedrae: acrid in the mouth, little hardship, warm in nature, enter lung, urinary bladder channel, have and send out cold inducing sweat, depressed lung-energy dispersing, the effect of inducing diuresis to remove edema is mainly used in the exterior excess syndromes such as fever without perspiration of affection of exogenous wind-cold; The rheumatic arthralgia pain; Pathogenic cold attacking the lung or accumulation of heat in the lung are to cough with asthma QI rising in reverse order, edema, the cards such as dysuria.
Rhizoma Panacis Majoris: bitter in the mouth, sweet, cold nature enters liver, lung, stomach warp, has the tonifying the lung yin nourishing, dissipating blood stasis hemostasis, the effect of reducing swelling and alleviating pain, be used for deficiency of both QI and YIN, thirsty, the cough due to consumptive disease of excessive thirst, various hemorrhages, such as haematemesis, hemoptysis, have blood in stool, hematuria, metrorrhagia, traumatic injury is hindered swollen, rheumatic arthritis, stomachache, acute toothache, laryngopharynx swelling and pain, the cards such as sore and toxic.
Rhizoma Polygonati Odorati: latin name Polygonati OdoratiRhizoma, sweet in the mouth, property is flat, attaches to the lung and stomach meridians, and has the effect of nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, cures mainly cough caused by dryness; Chronic cough; The dry throat and mouth of the cloudy liquid consumption of calentura wound; Interior-heat is quenched one's thirst; Deficiency of YIN diseases caused by exogenous pathogenic factor; Dizzy dizzy; The cards such as muscle arteries and veins spasm and pain.
Fructus Hippophae: latin name HippophaeFructus, sour in the mouth; Puckery; Warm in nature, have relieving cough and resolving phlegm; Invigorating the stomach and promoting digestion; The effect of promoting blood circulation to remove blood stasis.Cure mainly cough with copious phlegm; Pulmonary abscess; Dyspepsia; Abdominal pain due to retention of food; Stomachache; Intestinal is scorching; Amenorrhea; The cards such as traumatic injury congestive edema.
The Fructus Chebulae: latin name Chebulae Fructus, sour in the mouth, puckery, property is flat, returns lung, and large intestine channel has relieving diarrhea with astringents, astringing lung-QI and relieving cough, the effect of pathogenic fire reducing sore-throat relieving is used for the chronic diarrhea chronic dysentery, the proctoptosis of having blood in stool, cough and asthma due to lung deficiency, chronic cough is more than, the cards such as pharyngalgia hoarseness.
Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature is returned lung, stomach, kidney channel, have clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing is supported the effect of kidney, curing mainly pathogenic warmth joins the army, the pericardium that caves in, maculae caused by violent heat pathogen, the cards such as constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.
Caulis Piperis Kadsurae: acrid in the mouth, hardship, slightly warm in nature is returned Liver Channel, has wind-damp dispelling, the meridian dredging, the effect of stopping numbness pain cures mainly anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, the cards such as joint stuffiness.
Rhizoma Panacis Japonici: latin name Panacis JaponiciRhizoma, sweet in the mouth, little hardship, warm in nature, return liver, spleen, lung meridian, have strengthening by means of tonics, eliminating stasis to stop pain, the effect that hemostasis is eliminated the phlegm cures mainly after being ill weakness, chronic cough spitting of blood, cough with copious phlegm, the cards such as injury from falling down.
Lasiosphaera Seu Calvatia: acrid in the mouth, property are put down, and enter lung meridian, have moistening lung and nourishing throat, and the effect of detoxifcation hemostasis is used for laryngopharynx swelling and pain, lung-heat cough with asthma, pharyngitis, hoarseness, hemorrhage, chilblain, the cards such as decubital ulcer.
Radix Adenophorae: sweet in the mouth, little hardship, cold nature, enter lung, stomach warp, nourishing the lung to arrest cough is arranged, and the effect of nourishing the stomach to promote the production of body fluid is mainly used in lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, chronic cough expectorant blood, the cards such as deficiency of stomach-Yin, mouthfeel parched throat, constipation, the few tongue of red tongue, can improve cellular immunization and non-specific immunity, suppress humoral immunization, have the function of regulating immunologic balance.
Rhizoma Dioscoreae: sweet in the mouth, property are put down, and enter lung, spleen, stomach warp, and the spleen reinforcing nourishing the stomach is arranged, and lung benefiting reinforces the kidney, and the effect of YIN nourishing and the production of body fluid promoting cures mainly weakness of the spleen and stomach, the lack of appetite poor appetite of dysfunction of the spleen in transportation, the cards such as the vexed diarrhoea of gastral cavity.
Catechu: bitter in the mouth, puckery, cold nature is returned lung meridian, has the effect of removing dampness promoting tissue regeneration and ulcer healing, is used for ulcer being unable to heal, eczema, aphtha is fallen cards such as pouncing on the pain of injury, traumatic hemorrhage.
Radix Glycyrrhizae: sweet in the mouth, property is flat, enters 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, and is weak; Can alleviate contracture pain in the abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play the QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.
Chinese medicine composition provided by the invention is oral traditional Chinese medicine composition, as required, can be prepared into any regular dosage forms such as tablet, soft capsule, powder, granule, pill, mixture, can be according to the conventional method preparation of each dosage form, preferably, the dosage form of Chinese medicine composition is tablet and granule.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is granule, is specially:
The first step, described each crude drug component sent in the mixing and blending machine mix, then pour in the multi-function extractor, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, and temperature is controlled at 98 ~ 102 ℃, again obtains extracting solution, extracting solution is merged, obtain total extracting solution;
Second step, the pH value of regulating total extracting solution with hydrochloric acid is 5 ~ 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, and the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2 ~ 3:1, and at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 5 ~ 7 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing obtains and gets dry extract, be ground into fine powder, spray drying;
In the 3rd step, in dried fine powder, add corn dextrin and cane sugar powder, mixing, granulate splitting and fill every bag of 10g, with respect to the dried cream powder of 100 weight portions, the addition of corn dextrin is 80 weight portions ~ 120 weight portions, and the addition of cane sugar powder is 300 weight portions ~ 400 weight portions.
The present invention also provides the using method of above-mentioned Chinese medicinal composition granules, and granule is dissolved in the warm water, and is oral, and preferred each 1 bag, each 3 times.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is tablet, is specially:
The first step, described each crude drug component sent in the mixing and blending machine mix, then pour in the multi-function extractor, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, and temperature is controlled at 98 ~ 102 ℃, again obtains extracting solution, extracting solution is merged, obtain total extracting solution;
Second step, the pH value of regulating total extracting solution with hydrochloric acid is 5 ~ 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, and the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2 ~ 3:1, and at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 5 ~ 7 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing obtains and gets dry extract, be ground into fine powder, spray drying;
The 3rd step, behind the sodium carboxymethyl cellulose of fine powder 100 weight portions that spray drying is obtained and the polyvinylpyrrolidone of 60～100 weight portions, 30～50 weight portions, the microcrystalline Cellulose mixing of 120～180 weight portions, determining alcohol with 20～30 weight portions is that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 45 ℃～50 ℃ temperature ranges, with 16 mesh sieve granulate, and after adding the micropowder silica gel of the magnesium stearate of 7～9 weight portions and 6～8 weight portions, material is pressed into medicinal dispersing tablets, every 0.7g.
The present invention also provides the using method of above-mentioned Chinese medicine composition tablet, is specially: oral tablet, preferred each 3～4, each 3 times.
The present invention also provide above-mentioned Chinese medicine composition for the preparation of the treatment acute pharyngitis medicine in application.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
The concrete preparation of embodiment 1 granule 1
With Herba Sarcandrae 47g, Rhizoma Polygoni Cuspidati 51g, Rhizoma Acori Graminei 28g, Caulis Mahoniae 39g, Semen Sterculiae Lychnophorae 34g, Radix Scutellariae 82g, Periostracum Cicadae 21g, Dioscorea panthaica Prain et Burkill 47g, Radix Asteris 31g, Flos Sophorae 18g, Galla Chinensis 44g, Fructus Gleditsiae Abnormalis 27g, Herba Solidaginis 30g, Indigo Naturalis 66g, Herba Ephedrae 35g, Rhizoma Panacis Majoris 44g, Rhizoma Polygonati Odorati 23g, Fructus Hippophae 31g, Fructus Chebulae 25g, Radix Scrophulariae 32g, Caulis Piperis Kadsurae 40g, Rhizoma Panacis Japonici 35g, Lasiosphaera Seu Calvatia 21g, Radix Adenophorae 36g, Rhizoma Dioscoreae 44g, catechu 24g and Radix Glycyrrhizae 31g send in the mixing and blending machine and mix, then pour in the multi-function extractor, the distilled water that adds 5kg decocted 3 hours, the control steam pressure is at 0.1Mpa in decoction process, temperature is controlled at 100 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, the distilled water that adds 5kg decocted 3 hours, the control steam pressure is at 0.1Mpa in decoction process, temperature is controlled at 100 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution, the pH value of regulating total extracting solution with hydrochloric acid is 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2:1, at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 6 times of the quality of macroporous adsorbent resin is 80% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, dried cream powder is broken into fine powder, spray drying, the cane sugar powder that in dried fine powder, adds 1kg corn dextrin and 3.4kg, mixing is granulated, splitting and fill every bag of 10g.
The concrete preparation of embodiment 2 granules 2
With Herba Sarcandrae 45g, Rhizoma Polygoni Cuspidati 49g, Rhizoma Acori Graminei 26g, Caulis Mahoniae 37g, Semen Sterculiae Lychnophorae 32g, Radix Scutellariae 80g, Periostracum Cicadae 19g, Dioscorea panthaica Prain et Burkill 45g, Radix Asteris 29g, Flos Sophorae 16g, Galla Chinensis 42g, Fructus Gleditsiae Abnormalis 25g, Herba Solidaginis 28g, Indigo Naturalis 64g, Herba Ephedrae 33g, Rhizoma Panacis Majoris 42g, Rhizoma Polygonati Odorati 21g, Fructus Hippophae 29g, Fructus Chebulae 23g, Radix Scrophulariae 30g, Caulis Piperis Kadsurae 38g, Rhizoma Panacis Japonici 33g, Lasiosphaera Seu Calvatia 19g, Radix Adenophorae 34g, Rhizoma Dioscoreae 42g, catechu 22g and Radix Glycyrrhizae 29g send in the mixing and blending machine and mix, then pour in the multi-function extractor, the distilled water that adds 5kg decocted 3 hours, the control steam pressure is at 0.8Mpa in decoction process, temperature is controlled at 100 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, the distilled water that adds 5kg decocted 3 hours, the control steam pressure is at 0.08Mpa in decoction process, temperature is controlled at 100 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution, the pH value of regulating total extracting solution with hydrochloric acid is 5.5, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2:1, at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 6 times of the quality of macroporous adsorbent resin is 75% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, dried cream powder is broken into fine powder, spray drying, the cane sugar powder that in dried fine powder, adds 1kg corn dextrin and 3.4kg, mixing is granulated, splitting and fill every bag of 10g.
The concrete preparation of embodiment 3 granules 3
With Herba Sarcandrae 49g, Rhizoma Polygoni Cuspidati 53g, Rhizoma Acori Graminei 30g, Caulis Mahoniae 41g, Semen Sterculiae Lychnophorae 36g, Radix Scutellariae 84g, Periostracum Cicadae 23g, Dioscorea panthaica Prain et Burkill 49g, Radix Asteris 33g, Flos Sophorae 20g, Galla Chinensis 46g, Fructus Gleditsiae Abnormalis 29g, Herba Solidaginis 32g, Indigo Naturalis 68g, Herba Ephedrae 37g, Rhizoma Panacis Majoris 46g, Rhizoma Polygonati Odorati 25g, Fructus Hippophae 33g, Fructus Chebulae 27g, Radix Scrophulariae 34g, Caulis Piperis Kadsurae 42g, Rhizoma Panacis Japonici 37g, Lasiosphaera Seu Calvatia 23g, Radix Adenophorae 38g, Rhizoma Dioscoreae 46g, catechu 26g and Radix Glycyrrhizae 33g send in the mixing and blending machine and mix, then pour in the multi-function extractor, the distilled water that adds 5kg decocted 3 hours, the control steam pressure is at 0.8Mpa in decoction process, temperature is controlled at 100 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, the distilled water that adds 5kg decocted 3 hours, the control steam pressure is at 0.1Mpa in decoction process, temperature is controlled at 100 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution, the pH value of regulating total extracting solution with hydrochloric acid is 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2:1, at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 6 times of the quality of macroporous adsorbent resin is 70% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, dried cream powder is broken into fine powder, spray drying in dried fine powder, adds the cane sugar powder of 1kg corn dextrin and 3.4kg, mixing, granulate splitting and fill every bag of 10g.
The concrete preparation of embodiment 4 tablets 1
With Herba Sarcandrae 47g, Rhizoma Polygoni Cuspidati 51g, Rhizoma Acori Graminei 28g, Caulis Mahoniae 39g, Semen Sterculiae Lychnophorae 34g, Radix Scutellariae 82g, Periostracum Cicadae 21g, Dioscorea panthaica Prain et Burkill 47g, Radix Asteris 31g, Flos Sophorae 18g, Galla Chinensis 44g, Fructus Gleditsiae Abnormalis 27g, Herba Solidaginis 30g, Indigo Naturalis 66g, Herba Ephedrae 35g, Rhizoma Panacis Majoris 44g, Rhizoma Polygonati Odorati 23g, Fructus Hippophae 31g, Fructus Chebulae 25g, Radix Scrophulariae 32g, Caulis Piperis Kadsurae 40g, Rhizoma Panacis Japonici 35g, Lasiosphaera Seu Calvatia 21g, Radix Adenophorae 36g, Rhizoma Dioscoreae 44g, catechu 24g and Radix Glycyrrhizae 31g send in the mixing and blending machine and mix, then pour in the multi-function extractor, the distilled water that adds 5kg decocted 3 hours, the control steam pressure is at 0.1Mpa in decoction process, temperature is controlled at 100 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, the distilled water that adds 5kg decocted 3 hours, the control steam pressure is at 0.1Mpa in decoction process, temperature is controlled at 100 ℃, again obtain extracting solution, extracting solution is merged, obtain total extracting solution, the pH value of regulating total extracting solution with hydrochloric acid is 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2:1, at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 6 times of the quality of macroporous adsorbent resin is 80% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, dried cream powder is broken into fine powder, spray drying, with the fine powder 900g of spray drying acquisition and the polyvinylpyrrolidone of 720g, the sodium carboxymethyl cellulose of 360g, 1.35kg the microcrystalline Cellulose mixing after, determining alcohol with 200g is that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 50 ℃ of temperature ranges, with 16 mesh sieve granulate, and after the micropowder silica gel of the magnesium stearate of adding 70g and 50g, material is pressed into medicinal dispersing tablets, every 0.7g.
Embodiment 5 Chinese medicine composition toxicity tests detect
Laboratory animal
50 of kunming mices (being provided by Qingdao City's laboratory animal and zoopery center), female half and half, body weight 18～22g, be divided into 5 groups, every group 10,50 of Cavia porcelluss (being provided by Qingdao City's laboratory animal and zoopery center), male and female half and half, body weight is 250g ~ 300g, in 14 ages in week, be divided into 5 groups, 10 every group, experimental animal enters the cleaner assay chamber and raises 7d, observes animal activity, feed, defecation and all begins test without after unusual.(50cm * 32cm * 22.5cm) raise, male and female are divided cage with all steel rat breeding cage.Feed with the Mus full-valence pellet feed, by the keeper special messenger's feeding and management through training.Animal housing's illumination is sufficient, and heating ventilation and air-conditioning equipment is good, 18～25 ℃ of room temperatures, and relative humidity 50%～70%, test chamber is regularly sterilization routinely.
Experimental agents
The granule 1 of the 1st group to the 3rd group gavage embodiment of the invention of kunming mice 1 to embodiment 3 preparation is to granule 3, granule 1 to granule 3 is dissolved in the water, dissolve complete, be prepared into the solution of 1g/ml, the tablet 1 of the 4th group of gavage embodiment of the invention of kunming mice 4 preparations, tablet 1 is dissolved in the water, dissolve complete, be prepared into the solution of 1g/ml, the granule 1 of the 1st group to the 3rd group gavage embodiment of the invention of Cavia porcellus 1 to embodiment 3 preparation is to granule 3, granule 1 is dissolved in the water to granule 3, and dissolve complete is prepared into the solution of 1g/ml, the tablet 1 of the 4th group of gavage embodiment of the invention of Cavia porcellus 4 preparations, tablet 1 is dissolved in the water, and dissolve complete is prepared into the solution of 1g/ml.
The kunming mice acute toxicity testing
With the 1st group to the 4th group of kunming mice respectively according to top method administration, each 0.4ml/10g, blank group gavage equivalent normal saline, behind front fasting (the can't help water) 12h of test, the 1st group to the 4th group every day 1 gastric infusion, 14d records the situations such as tested mice behavior, activity, food ration, body weight, feces, death continuously, and not dead mice is put to death behind 14d and performs an autopsy on sb．.
The 1st group of mice to the 4th group of 40g (crude drug)/kg dosed administration of Chinese medicine composition, saw that the mice hair color was smooth, feces is brown the same day, quality is rarer soft, ingest, movable less, mice activity, food ration, body weight gain, feces etc. all recover normally after the 2nd day, compare no significant difference with the blank group; And without dead and other unusual generations, two groups perform an autopsy on sb． after putting to death simultaneously in the 14d, and each main organs (heart, liver, spleen, lung, kidney) is no abnormality seen by the naked eye.
Cavia porcellus repetitively administered toxicity test
With the 1st group to the 4th group of Cavia porcellus respectively according to top method administration, each 0.4ml/10g, blank group gavage equivalent normal saline, behind front fasting (the can't help water) 12h of test, the 1st group to the 4th group every day 1 gastric infusion, continuous 5 weeks, record the situations such as tested Cavia porcellus behavior, activity, food ration, body weight, feces, death, Guinea Pigs Died is not put to death after 5 weeks and is performed an autopsy on sb．.
Experimental animal behavior activity within whole experimental period, diet, defecation and shown no obvious abnormalities by situations such as hair color pools have no vomiting, sialorrhea, shed tears, the symptom such as dyspnea.Duration of test has individual animal dead, takes up Anatomical Observation through cage, and dead animal shows no obvious abnormalities, and causes death for administration is improper.
Growth promoter is good after each treated animal administration, and body weight gain and blank group relatively show no obvious abnormalities.
Put to death animal after the off-test, dissect immediately, the major organs such as perusal brain, heart, liver, spleen, lungs, kidney, each organ surface is smooth, without adhesion, color and luster is normal, has no hyperemia, swelling, hemorrhage, downright bad, adhesion, gastrointestinal is without expansion, and intestinal wall is without abnormal phenomenas such as edema, hemorrhage, ulcer.
Heart: the myocardial cell band is clear, and nuclear is placed in the middle, and a matter has no vasodilation and cell infiltration; Visceral pericardium, endocardium are without unusually.Liver: hepatocyte is arranged and is strand, and the lobules of liver structure is clear, and the portal area has no cell infiltration and fibrous connective tissue hypertrophy, the hepatocyte polygon, and slurry is abundant, and nuclear is justified greatly.Spleen: fibrous capsule is complete, and without thickening, acini lienalis is high-visible, and trabecularism is normal, and red pulp, white pulp are clear, have no degeneration, necrosis and cell infiltration.Lungs: the bronchioles structural integrity, be methodically arranged, the alveolar wall structural integrity, lung interval and bronchus are excellent, and intracavity has no degeneration, necrosis and cell infiltration without obvious exudate.Kidney: Renal Cortex, medullary substance, glomerule structure are normal, and the messangial cell number does not increase, and the blood capillary tube chamber is without expansion, matter no abnormality seen between renal cells, kidney.Brain: organizational structure is normal, and neurocyte, neurogliocyte form are normal, each layer neuronal cell Non Apparent Abnormality.
Embodiment 6 zooperies
Laboratory animal
60 of kunming mices (being provided by Qingdao City's laboratory animal and zoopery center), female half and half, body weight 18～22g is divided into 3 groups, 20 every group.
Experimental agents
The granule 1 of the present invention's preparation, concentration is 15% ammonia; Glacial acetic acid; Laryngeal spray.
Grouping and administration
Be divided into Normal group, model group, treatment group by the experiment treatment conditions, the granule 1 for the treatment of group gavage embodiment 1 preparation is dissolved in granule 1 in the water, and dissolve complete is prepared into the solution of 1g/ml, every day gavage medicine 20g/(kgd) continuous 14d.Treatment group and model group are since the 12d atomizing, and continuous each 15% ammonia of upper and lower noon of 3d sprays its pharyngeal 1 time, at every turn with aerosol apparatus spray 3 times.Normal group and model group Cavia porcellus gavage every day normal saline 0.5mL/100g, the pharyngeal spray distilled water of normal control Cavia porcellus.
The research of antitussive effect
Cough number of times in cough latent period and the 2min of the above-mentioned group rat of observed and recorded, 5min.
Antiinflammatory action research
On the swollen impact of rat granuloma
Above-mentioned group each Mus of administration 10d under aseptic condition at the subcutaneous heavy sterilization cotton balls of 20mg of respectively implanting of left and right sides hind leg footpath section.The administration 14d rear execution rat of weighing is opened former otch, and cotton balls is taken out together with connective tissue on every side, reject fatty tissue, in 70 ℃ of drying in oven, weigh, calculate and respectively to organize granuloma weight, with claim granulation tissue weight deduct the cotton balls original weight and namely get granuloma weight.
The detection of serum interleukin-6 and tumor necrosis factor-alpha TNF
Abdominal aortic blood before above-mentioned rat is put to death requires to detect IL-6 and TNF by test kit.
Statistical method
Carry out statistical disposition with SPSS for Windows10.0 version software.Measurement data adopts the t check, and enumeration data adopts χ
2Check.
The result
Chinese medicine composition of the present invention the results are shown in Table 1 to guinea pig cough's impact.
Table 1 Chinese medicine composition is on guinea pig cough's impact
| Group | n | Incubation period | 2min | 5min |
| Normal group | 20 | 15.27±1.27 | 17.33±2.16 | 18.51±1.73 |
| Model group | 20 | 25.33±1.94 | 32.18±2.03 | 41.92±1.62 |
| Treatment group | 20 | 20.82±1.03 | 22.51±2.30 | 19.35±1.84 |
As can be seen from Table 1, adopt Chinese medicine composition of the present invention can obviously prolong cough latent period, reduce the cough number of times.
Chinese medicine composition the results are shown in Table 2 to the impact of Cavia porcellus granuloma induced by implantation of cotton pellets.
Table 2 Chinese medicine composition is on the impact of Cavia porcellus granuloma induced by implantation of cotton pellets
Can find out by table 2, adopt Chinese medicine composition of the present invention can obviously suppress the Cavia porcellus granuloma that cotton balls causes.
Chinese medicine composition the results are shown in Table 3 to the impact of Cavia porcellus IL-6 and TNF content.
Table 3 Chinese medicine composition is on the impact of Cavia porcellus IL-6 and TNF content
| Group | n | IL-6（pg/mL） | TNF（ng/mL） |
| Normal group | 20 | 120.59±23.61 | 77.63±5.32 |
| Model group | 20 | 235.91±27.31 | 90.22±4.91 |
| Treatment group | 20 | 153.99±30.17 | 81.19±3.61 |
As can be seen from Table 3, Chinese medicine composition of the present invention can significantly reduce the content of IL-6 and TNF.
Embodiment 7 clinical datas
Physical data
All 260 routine acute pharyngitis patients are the patient in December, 2009～2011 year July, get rid of have the inclination, serious disease and the psychotics such as liver, kidney.Male 152 examples wherein, women 108 examples, 6～64 years old age, 37 years old mean age.Main clinic symptoms: pharyngalgia, silent, dry pharynx, acataposis, cough, the not high or low heat of body temperature (being lower than 39 ℃), headache, the whole body is uncomfortable or ache constipation with dry stool, yellow urine, red tongue, yellow and greasy fur, pharyngeal obvious hyperemia or edema, antiadoncus etc., laboratory inspection: numeration of leukocyte is normal or on the low side, and percentage of lymphocyte raises; X-ray checks pulmonary's Non Apparent Abnormality discovery.
The experiment grouping
The patient is divided into 2 groups immediately, treatment group 150 examples, matched group 110 examples, 87 examples in the treatment group, women 73 examples, case is the longest 3 days, the shortest 12h, average (1.52 ± 0.61) sky.Matched group man 67 examples, women 43 examples; The course of disease is the longest 2 days, the shortest 12h, average course of disease (1.30 ± 0.49) sky.2 groups of case physical data are relatively learned by statistics and are processed there was no significant difference (P＞0.05), have comparability.
The Western medicine diagnose standard
⑴ medical history: suffer from cold, tired, tobacco and wine are excessive, the reasons such as various physicochemical irritations.⑵ clinical symptoms: pharyngeal drying, scorching hot pain or swallow pain; The heating fear of cold, inappetence is ached all around.Cough, watery nasal discharge.⑶ check: pharyngeal mucosa is congested, color is scarlet, pharynx rear wall lymph follicle and isthmus faucium are red and swollen, and is local or Huang, white secretions, uvula soft palate edema arranged.Possessing has pharyngeal symptom, and has the above inspection positive to levy, in conjunction with medical history diagnosable be acute pharyngitis.
Tcm diagnosis
Disease is seen: pharyngalgia, scorching hot, the dysphagia of dry pharynx, and mouth is little thirsty, and aversion to cold is light, and heating is heavy, and it is deep to cough, the yellow skin of coughing up phlegm, red swelling of the pharynx, uvula redness are swallowed the rear wall follicle hypertrophy, tongue tip side of red, tongue fur BOHUANG, floating and rapid pulse.
Symptom and sign grade scale
1. pharyngalgia: light (+): pharyngeal dull pain does not affect and swallows; In (++): pharyngeal pain, pain increases the weight of when swallowing; Heavy (+++) pharyngeal severe pain, dysphagia.2. heating: light (+): 37.5 ℃～38 ℃ of body temperature; In (++): 38.1 ℃～39 ℃ of body temperature; Heavy (+++): body temperature is more than 39.1 ℃.3. staphyledema: light (+): the uvula enlargement does not affect and swallows; In (++): the uvula enlargement is sagging, and foreign body sensation is arranged when swallowing; Heavy (+++): the uvula enlargement, contact pharyngeally, it is also obvious not swallow foreign body sensation.4. pharyngeal mucosa is congested: light (+): bottleneck throat is slightly congested, but not obvious; In (++): color is red between weight; Heavy (+++): red swelling of the pharynx is obvious, and color is red.5. cough is coughed up phlegm light (+): be interrupted cough daytime, and expectorant easily brings up, and expectorant is that white is sticky; In (++): cough is coughed up phlegm, and between weight, expectorant is glutinous yellow; Heavy (+++): the frequent or play of round the clock cough is coughed, and the thick Huang of abundant expectoration is not easy to bring up, and impact is had a rest.
Observation index
1. symptom: mainly observe pharyngeal pain, heating; 2. pharyngeal sign: pharyngeal mucosa is congested, staphyledema; 3. temperature taking: during the treatment, each patient detects body temperature routinely, and performs record.
Therapeutic Method
The granule 1 of the oral embodiment of the invention for the treatment of group 1 preparation is dissolved in it in warm water and takes, and each oral 10g, 5 days 1 courses for the treatment of, takes 2 courses for the treatment of at every day 3 times.
Matched group Administration of roxithromycin capsule, every day 2 times, each 150mg.
Criterion of therapeutical effect
Recovery from illness: 5 with interior clinical symptoms and sign disappearance with interior sx↓ on 3rd in medication; Produce effects: sx↓ in the medication 5 days, most of sign disappears; Effectively: sx↓ in the medication 5 days, the part sign disappears; Invalid: medication 5 days with interior clinical symptoms and sign without improvement.
Statistical method
Carry out statistical disposition with SPSS for Windows10.0 version software.Measurement data adopts the t check, and enumeration data adopts χ
2Check.
The result
Clinical efficacy comparison the results are shown in Table 4.
Table 4 liang group Clinical efficacy comparison
As can be seen from Table 4, adopt Chinese medicine composition of the present invention can obviously improve the therapeutic efficiency of acute pharyngitis.
Two groups of patients cure required time relatively, the results are shown in Table 5.
Table 5 a liang group patient cures required time relatively
| Group | Cure number | Average cure time (my god) |
| Treatment group | 81 | 2.63±0.51 |
| Matched group | 35 | 4.03±0.77 |
As can be seen from Table 5, adopt Chinese medicine composition of the present invention can obviously reduce the treatment time of acute pharyngitis.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (10)
1. Chinese medicine composition that is used for the treatment of acute pharyngitis, it is characterized in that: the crude drug of described Chinese medicine composition comprises Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that: the weight portion of each crude drug is respectively Herba Sarcandrae 42 weight portions ~ 52 weight portions in the described Chinese medicine composition, Rhizoma Polygoni Cuspidati 46 weight portions ~ 56 weight portions, Rhizoma Acori Graminei 23 weight portions ~ 33 weight portions, Caulis Mahoniae 34 weight portions ~ 44 weight portions, Semen Sterculiae Lychnophorae 29 weight portions ~ 39 weight portions, Radix Scutellariae 77 weight portions ~ 87 weight portions, Periostracum Cicadae 16 weight portions ~ 26 weight portions, Dioscorea panthaica Prain et Burkill 42 weight portions ~ 52 weight portions, Radix Asteris 26 weight portions ~ 36 weight portions, Flos Sophorae 13 weight portions ~ 23 weight portions, Galla Chinensis 39 weight portions ~ 49 weight portions, Fructus Gleditsiae Abnormalis 22 weight portions ~ 32 weight portions, Herba Solidaginis 25 weight portions ~ 35 weight portions, Indigo Naturalis 61 weight portions ~ 71 weight portions, Herba Ephedrae 30 weight portions ~ 40 weight portions, Rhizoma Panacis Majoris 39 weight portions ~ 49 weight portions, Rhizoma Polygonati Odorati 18 weight portions ~ 28 weight portions, Fructus Hippophae 26 weight portions ~ 36 weight portions, Fructus Chebulae's 20 weight portions ~ 30 weight portions, Radix Scrophulariae 27 weight portions ~ 37 weight portions, Caulis Piperis Kadsurae 35 weight portions ~ 45 weight portions, Rhizoma Panacis Japonici 30 weight portions ~ 40 weight portions, Lasiosphaera Seu Calvatia 16 weight portions ~ 26 weight portions, Radix Adenophorae 31 weight portions ~ 41 weight portions, Rhizoma Dioscoreae 39 weight portions ~ 49 weight portions, catechu 19 weight portions ~ 29 weight portions and Radix Glycyrrhizae 26 weight portions ~ 36 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: the weight portion of each crude drug is respectively Herba Sarcandrae 45 weight portions ~ 49 weight portions in the described Chinese medicine composition, Rhizoma Polygoni Cuspidati 49 weight portions ~ 53 weight portions, Rhizoma Acori Graminei 26 weight portions ~ 30 weight portions, Caulis Mahoniae 37 weight portions ~ 41 weight portions, Semen Sterculiae Lychnophorae 32 weight portions ~ 36 weight portions, Radix Scutellariae 80 weight portions ~ 84 weight portions, Periostracum Cicadae 19 weight portions ~ 23 weight portions, Dioscorea panthaica Prain et Burkill 45 weight portions ~ 49 weight portions, Radix Asteris 29 weight portions ~ 33 weight portions, Flos Sophorae 16 weight portions ~ 20 weight portions, Galla Chinensis 42 weight portions ~ 46 weight portions, Fructus Gleditsiae Abnormalis 25 weight portions ~ 29 weight portions, Herba Solidaginis 28 weight portions ~ 32 weight portions, Indigo Naturalis 64 weight portions ~ 68 weight portions, Herba Ephedrae 33 weight portions ~ 37 weight portions, Rhizoma Panacis Majoris 42 weight portions ~ 46 weight portions, Rhizoma Polygonati Odorati 21 weight portions ~ 25 weight portions, Fructus Hippophae 29 weight portions ~ 33 weight portions, Fructus Chebulae's 23 weight portions ~ 27 weight portions, Radix Scrophulariae 30 weight portions ~ 34 weight portions, Caulis Piperis Kadsurae 38 weight portions ~ 42 weight portions, Rhizoma Panacis Japonici 33 weight portions ~ 37 weight portions, Lasiosphaera Seu Calvatia 19 weight portions ~ 23 weight portions, Radix Adenophorae 34 weight portions ~ 38 weight portions, Rhizoma Dioscoreae 42 weight portions ~ 46 weight portions, catechu 22 weight portions ~ 26 weight portions and Radix Glycyrrhizae 29 weight portions ~ 33 weight portions.
4. such as the described Chinese medicine composition of claims 1 to 3, it is characterized in that: the weight portion of each crude drug is respectively Herba Sarcandrae 47 weight portions in the described Chinese medicine composition, Rhizoma Polygoni Cuspidati 51 weight portions, Rhizoma Acori Graminei 28 weight portions, Caulis Mahoniae 39 weight portions, Semen Sterculiae Lychnophorae 34 weight portions, Radix Scutellariae 82 weight portions, Periostracum Cicadae 21 weight portions, Dioscorea panthaica Prain et Burkill 47 weight portions, Radix Asteris 31 weight portions, Flos Sophorae 18 weight portions, Galla Chinensis 44 weight portions, Fructus Gleditsiae Abnormalis 27 weight portions, Herba Solidaginis 30 weight portions, Indigo Naturalis 66 weight portions, Herba Ephedrae 35 weight portions, Rhizoma Panacis Majoris 44 weight portions, Rhizoma Polygonati Odorati 23 weight portions, Fructus Hippophae 31 weight portions, Fructus Chebulae's 25 weight portions, Radix Scrophulariae 32 weight portions, Caulis Piperis Kadsurae 40 weight portions, Rhizoma Panacis Japonici 35 weight portions, Lasiosphaera Seu Calvatia 21 weight portions, Radix Adenophorae 36 weight portions, Rhizoma Dioscoreae 44 weight portions, catechu 24 weight portions and Radix Glycyrrhizae 31 weight portions.
5. such as the described Chinese medicine composition of claim 1 to 4, it is characterized in that: the dosage form of described Chinese medicine composition is tablet, soft capsule, powder, granule, pill, mixture.
The described Chinese medicine composition of claim 1 to 5 for the preparation of the treatment acute pharyngitis medicine in application.
7. the preparation method of the described Chinese medicine composition of claim 1 to 5 is characterized in that: when the dosage form of described Chinese medicine composition is granule, is specially,
The first step, described each crude drug component sent in the mixing and blending machine mix, then pour in the multi-function extractor, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, and temperature is controlled at 98 ~ 102 ℃, again obtains extracting solution, extracting solution is merged, obtain total extracting solution;
Second step, the pH value of regulating total extracting solution with hydrochloric acid is 5 ~ 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, and the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2 ~ 3:1, and at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 5 ~ 7 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing obtains and gets dry extract, be ground into fine powder, spray drying;
In the 3rd step, in dried fine powder, add corn dextrin and cane sugar powder, mixing, granulate, splitting and filling is with respect to the dried cream powder of 100 weight portions, the addition of corn dextrin is 80 weight portions ~ 120 weight portions, and the addition of cane sugar powder is 300 weight portions ~ 400 weight portions.
8. the preparation method of the described Chinese medicine composition of claim 1 to 5 is characterized in that: when the dosage form of described Chinese medicine composition is tablet, is specially,
The first step, described each crude drug component sent in the mixing and blending machine mix, then pour in the multi-function extractor, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, and temperature is controlled at 98 ~ 102 ℃, again obtains extracting solution, extracting solution is merged, obtain total extracting solution;
Second step, the pH value of regulating total extracting solution with hydrochloric acid is 5 ~ 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, and the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2 ~ 3:1, and at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 5 ~ 7 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing obtains and gets dry extract, be ground into fine powder, spray drying;
The 3rd step, behind the sodium carboxymethyl cellulose of fine powder 100 weight portions that spray drying is obtained and the polyvinylpyrrolidone of 60～100 weight portions, 30～50 weight portions, the microcrystalline Cellulose mixing of 120～180 weight portions, determining alcohol with 20～30 weight portions is that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 45 ℃～50 ℃ temperature ranges, with 16 mesh sieve granulate, and after adding the micropowder silica gel of the magnesium stearate of 7～9 weight portions and 6～8 weight portions, material is pressed into medicinal dispersing tablets.
9. Chinese medicinal composition granules that is used for the treatment of acute pharyngitis, it is characterized in that: the crude drug of described Chinese medicinal composition granules comprises Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae
The preparation method of described granule is specially,
The first step, described each crude drug component sent in the mixing and blending machine mix, then pour in the multi-function extractor, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, and temperature is controlled at 98 ~ 102 ℃, again obtains extracting solution, extracting solution is merged, obtain total extracting solution;
Second step, the pH value of regulating total extracting solution with hydrochloric acid is 5 ~ 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, and the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2 ~ 3:1, and at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 5 ~ 7 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing obtains and gets dry extract, be ground into fine powder, spray drying;
In the 3rd step, in dried fine powder, add corn dextrin and cane sugar powder, mixing, granulate, splitting and filling is with respect to the dried cream powder of 100 weight portions, the addition of corn dextrin is 80 weight portions ~ 120 weight portions, and the addition of cane sugar powder is 300 weight portions ~ 400 weight portions.
10. Chinese medicine composition tablet that is used for the treatment of acute pharyngitis, it is characterized in that: the crude drug of described Chinese medicine composition tablet comprises Herba Sarcandrae, Rhizoma Polygoni Cuspidati, Rhizoma Acori Graminei, Caulis Mahoniae, Semen Sterculiae Lychnophorae, Radix Scutellariae, Periostracum Cicadae, Dioscorea panthaica Prain et Burkill, Radix Asteris, Flos Sophorae, Galla Chinensis, Fructus Gleditsiae Abnormalis, Herba Solidaginis, Indigo Naturalis, Herba Ephedrae, Rhizoma Panacis Majoris, Rhizoma Polygonati Odorati, Fructus Hippophae, Fructus Chebulae, Radix Scrophulariae, Caulis Piperis Kadsurae, Rhizoma Panacis Japonici, Lasiosphaera Seu Calvatia, Radix Adenophorae, Rhizoma Dioscoreae, catechu and Radix Glycyrrhizae
The preparation method of described tablet is specially,
The first step, described each crude drug component sent in the mixing and blending machine mix, then pour in the multi-function extractor, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, temperature is controlled at 98 ~ 102 ℃, filter, obtain extracting solution, filtering residue is poured in the multi-function extractor again, adding decocted 2 ~ 3 hours with respect to the distilled water of 4 ~ 6 times of each crude drug quality sums, the control steam pressure is at 0.05 ~ 0.1Mpa in decoction process, and temperature is controlled at 98 ~ 102 ℃, again obtains extracting solution, extracting solution is merged, obtain total extracting solution;
Second step, the pH value of regulating total extracting solution with hydrochloric acid is 5 ~ 6, the total extracting solution that to regulate subsequently behind the pH value is added on the large adsorption hole resin column, and the quality of total extracting solution and the mass ratio of macroporous adsorbent resin are 2 ~ 3:1, and at first water rushes to effluent colourless, using subsequently determining alcohol with respect to 5 ~ 7 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution, collect eluent, the concentrating under reduced pressure desolventizing obtains and gets dry extract, be ground into fine powder, spray drying;
The 3rd step, behind the sodium carboxymethyl cellulose of fine powder 100 weight portions that spray drying is obtained and the polyvinylpyrrolidone of 60～100 weight portions, 30～50 weight portions, the microcrystalline Cellulose mixing of 120～180 weight portions, determining alcohol with 20～30 weight portions is that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 45 ℃～50 ℃ temperature ranges, with 16 mesh sieve granulate, and after adding the micropowder silica gel of the magnesium stearate of 7～9 weight portions and 6～8 weight portions, material is pressed into medicinal dispersing tablets.
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| CN109316551A (en) * | 2018-11-20 | 2019-02-12 | 山东罗欣乐康制药有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating acpuei pharyngitis |
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| CN101732500A (en) * | 2008-11-11 | 2010-06-16 | 戚寰 | Medicine for preventing and treating acute and chronic pharyngitis and sphagitis |
| CN101954062A (en) * | 2010-09-29 | 2011-01-26 | 安政权 | Medicament for treating chronic pharyngitis |
| CN102309687A (en) * | 2011-09-22 | 2012-01-11 | 王璐 | Medicament for treating faucitis |
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| CN101249213A (en) * | 2008-03-24 | 2008-08-27 | 李运乃 | Hot drinks preparations for curing chronic lung-stomach yin deficiency type pharyngitis |
| CN101732500A (en) * | 2008-11-11 | 2010-06-16 | 戚寰 | Medicine for preventing and treating acute and chronic pharyngitis and sphagitis |
| CN101954062A (en) * | 2010-09-29 | 2011-01-26 | 安政权 | Medicament for treating chronic pharyngitis |
| CN102309687A (en) * | 2011-09-22 | 2012-01-11 | 王璐 | Medicament for treating faucitis |
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| CN109316551A (en) * | 2018-11-20 | 2019-02-12 | 山东罗欣乐康制药有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating acpuei pharyngitis |
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