CN105770679A - Chinese herbal mouthwash for treating fungal infection of oral cavity - Google Patents

Chinese herbal mouthwash for treating fungal infection of oral cavity Download PDF

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Publication number
CN105770679A
CN105770679A CN201610285763.4A CN201610285763A CN105770679A CN 105770679 A CN105770679 A CN 105770679A CN 201610285763 A CN201610285763 A CN 201610285763A CN 105770679 A CN105770679 A CN 105770679A
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herba
radix
chinese medicine
rhizoma
chinese herbal
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张绪伟
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Abstract

The invention provides Chinese herbal mouthwash for treating fungal infection of the oral cavity. The Chinese herbal mouthwash is made of Chinese herbal compound extracts used for treating fungal infection of the oral cavity, potassium sorbate, vitamin C, cane sugar, citric acid stearoyl monoglyceride, sodium carboxymethylcellulose, octadecanol polyxyethylene ether, sodium dodecyl sulfate, ethyl alcohol and water. The Chinese herbal mouthwash can effectively kill candida albicans, and can help the oral cavity balance other flora. In addition, antifungal drug is high in toxicity and drug resistance, patients can use the Chinese herbal mouthwash according to their physique, vital qi can be resumed to resist against diseases, and fungal infection of the oral cavity can be quickly treated. The Chinese herbal mouthwash as the preparation can be used on local focuses and has quick effect, so that fungus can be avoided from entering digestive tracts along with taken-in medicine to cause other infections, and the Chinese herbal mouthwash has better application prospect.

Description

The Chinese medicine gargle of preventing and treating buccal cavity fungal infection
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of Chinese medicine gargle preventing and treating buccal cavity fungal infection.
Background technology
Oral candidiasis is the oral keritonocytes caused by fungus-candida infection.In recent years, due to the extensive use clinically of antibiotic and immunosuppressant, occurring dysbacteriosis or immunity to reduce, and make internal organs, skin, mucosa fungal infection person increasing, the incidence rate of Oral mucous Candidiasis also increases accordingly.It is reported, this kind of Pseudomonas candidiasis, candida pseudotropicalis in the candidiasis of Cryptococcaeceae, height, wherein Candida albicans is topmost pathogen.
The Healthy People oral cavity of 25%～50%, vagina, digestive tract with candidiasis, but can not fallen ill；But not Pathogenic Candida, under certain conditions, can be converted into pathogenic, therefore have people to claim beads shape bacterium to be conditioned pathogen.In child's moniliasis white mouth, denture stomatitis, angular cheilitis, monilial leukoderma and chronic mucosa cutaneous Candida patient, the recall rate of Candida albicans is all more than 50%.
Oral candidiasis can be divided into by its major lesions position: monilial stomatitis, candidiasis cheilitis, candidiasis angular cheilitis, chronic mucosa dermatocandidiasis.The oral disease relevant with infection by Candida albicans also has: lichen planus, hairy tongue and median rhomboid glossitis.
1. monilial stomatitis
(1) acute pseudomembrane type (moniliasis white mouth)
Neonatal thruss is many to be occurred in 2～8 days after life, predilection site is cheek, tongue, soft palate and lip, damaged area mucosa is congested, there is the soft fleck of the color Bai Ruxue being dispersed in, such as hatpin head size, soon being namely mutually fused to white or blue and white velvet shape patch, and can continue to expand, severe patient involves tonsil, pharyngeal, gingiva.Early stage mucosa hyperemia is more apparent, therefore is cerise and snow-white contrast.And outmoded disease damage mucosa hyperemia is gone down, white patch band is faint yellow.Patch attachment is very not tight, slightly firmly can wipe, expose red mucosal erosion face and hyporrhea.Infant dysphoria, cry, dysilthia, sometimes have grade fever, general reaction is generally lighter；But minority case, it is possible to spread to esophagus and bronchus, causes monilial esophagitis or pulmonary candidiasis.A few patients also can concurrently child's generalized cutaneous candidiasis, chronic mucosa dermatocandidiasis.
(2) acute erythema type
Adult acute's monilial stomatitis can have pseudomembrane, and with angular cheilitis, but main manifestations is that mucosa hyperemia is rotten to the corn and back nipple be masses shrank sometimes, and surrounding tongue fur thickens.Patient Chang Shouxian has parageusia or gustatory anesthesia, xerostomia, mucosa causalgia.
(3) chronic hypertrophic
The cheek mucosa disease damage of this type, is often symmetrically located at trigonum inside bicker, in nodositas or graininess hypertrophy, or for set white cutin speckle, similar general mucous membrane white spot closely.Palatine disease damage can be developed by denture stomatitis, and mucosa is papillary hyperplasia；Back disease damage, can behave as filiform papillae propagation, and color is greyish black, is called hairy tongue, and therefore hairy tongue falls within this type.
(4) chronic atrophic type
This type is also known as denture stomatitis, and damaging part is everlasting the palate of maxillary denture palate contacts side surfaces, gum mucosa, is more common in female patient.Mucosa is shiny red edema, or the streak or mottled pseudomembrane of yellow-white.Have in speckle or the pseudomembrane of most patient, can look into and see Candida albicans.80% is had in the patient of candidiasis cheilitis or angular cheilitis to have denture stomatitis.Denture stomatitis also often occurs with the mastoid process hypertrophy of palate simultaneously, before considering excision, should first carry out antifungal therapy, it is possible to alleviate the degree of hypertrophy significantly, reduces the scope needing operation.
2. monilial cheilitis
Primary disease is divided into amphitypy by Gansen, the cherry rotten to the corn face of erosive type person part long-term existence in lower red lip lip, around had keratinization phenomenon, surface desquamation, and therefore very easily obscured with discoid lupus erythematosus disease damage, also similar actinic cheilitis.Granular pattern person shows as lower flaps, and red lip skin interface place often has and is dispersed in prominent little granule, extremely similar cheilitis glandularis.
3. candidiasis angular cheilitis
Primary disease is characterized by often suffering from for bilateral, and the skin in bicker district and mucosa are chapped, and contiguous skin is congested with mucosa, and often there are erosion and exudate in the place of chapping, or has thin crust, pain or hemorrhage when dehiscing.Simultaneously can concurrently glossitis, cheilitis, scrotitis or vulvitis.
4. chronic mucosa dermatocandidiasis this be the candida albicans infection disease of one group of specific type, extent of disease relates to oral mucosa, skin and nail matrix.It is believed that it has the rate that cancerates higher than 4%, should watch out for, strive for early stage biopsy, clarify a diagnosis.Many from falling ill in petticoats, the course of disease several years, to many decades, is often accompanied by endocrine or immunologic dysfunction, cellular immune function low.
(1) Multiple Endocrine disease type is everlasting preadolescence sequela, and the initial stage shows as hypoparathyroidism or hypoadrenocorticism more and chronic kerato-conjunctival is scorching, but monilial stomatitis is probably primary disease performance the earliest.
(2) T lymphocyte defect disease type
Primary disease is found in hypergammaglobulinemia and the netted tumor patient of malignant lymphatic.
(3) the chronic mucosa cutaneous Candida of family
This type is found in child, it is possible to adult's (delayed) that onset is later in 35 years old, all with ferrum absorb, Developmental and Metabolic Disorder relevant, it may be possible to make Candida albicans inhibitive factor reduce during due to iron deficiency, cause breeding and the invasion and attack of pathogenic bacterium.All kinds of chronic mucosa dermatocandidiasiss, the symptom first showed, is all often long-term more not or the thrush of recurrent exerbation and angular cheilitis；Then thicken at Head And Face and extremity generation erythema shape desquamation erythra, deck, it is possible to alopecia and the cornu cutaneum sample infringement of frons, nose occur.
Western medical treatment can only carry out local treatment and antifungal therapy for symptom, except using antifungal agent beyond the region of objective existence, health is weak, there are immunodeficiency or the patient of general disease relevant with it and chronic monilial infection, often need to be aided with the complex treatment measure of enhancing human body immunity power, as injected transfer factor, thymosin, lipopolysaccharide etc., supplement chalybeate, vitamin A；And repeatedly a small amount of blood transfusion etc..The treatment time of thrush answers proper extension, generally schedules to last with 14 days, and too early drug withdrawal is easily caused a disease and damaged recurrence.And the course for the treatment of of hypertrophic (proliferous type) should be longer, the inapparent Candida albicans white macula of curative effect, excision should be considered early.
Chinese medicine is for primary disease prescription medicine, it is possible not only to effective Killing Candida Albicans, and contribute to recovering other colony balances of oral cavity, in addition, antifungal drug toxicity and drug resistance are bigger, and Chinese medicine carries out medication according to the body constitution of patient, can reinforcing body resistance, anti-heresy is gone out, treat rapidly buccal cavity fungal infection, one characteristic of invention formulation is the dosage form adopting Chinese medicine gargle, can focal medication, rapid-onset, after avoiding oral administration medicament, fungus is entered internal by digestive tract, cause other to infect, there is very good application prospect, suitable in clinical expansion.
Summary of the invention
The technical problem to be solved is to provide a kind of Chinese medicine gargle for preventing and treating buccal cavity fungal infection, can reinforcing body resistance, anti-heresy is gone out, and treats rapidly buccal cavity fungal infection, and one characteristic of invention formulation is the dosage form adopting Chinese medicine gargle, can focal medication, rapid-onset, it is to avoid after oral administration medicament, fungus is entered by digestive tract internal, cause other to infect, there is very good application prospect, it is adaptable to clinical expansion.
For solving above-mentioned technical problem, the invention provides a kind of Chinese medicine compound extract component for preventing and treating buccal cavity fungal infection, its crude drug includes Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Scrophulariae, Flos Chrysanthemi Indici, Herba Lobeliae Chinensis, Herba Lophatheri, Flos Lonicerae, Herba Taraxaci, Rhizoma Smilacis Glabrae, Semen Arecae, Radix Et Rhizoma Rhei, Herba Asari, Cortex Moutan, Herba Menthae, Borneolum Syntheticum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Trichosanthis, Bulbus Lilii, Radix Ophiopogonis, Herba Agrimoniae, Rhizoma Atractylodis, Semen Alpiniae Katsumadai, Herba Eupatorii, Herba Pogostemonis, Herba Dendrobii, Concha Ostreae (calcined) and Radix Glycyrrhizae.
nullWherein，The weight respectively Radix Scutellariae 25g～35g of each crude drug in described Chinese medicine compound extract component、Rhizoma Coptidis 30g～45g、Cortex Phellodendri 25g～35g、Radix Sophorae Flavescentis 15g～25g、Radix Scrophulariae 10g～25g、Flos Chrysanthemi Indici 10g～20g、Herba Lobeliae Chinensis 10g～20g、Herba Lophatheri 10g～20g、Flos Lonicerae 20g～30g、Herba Taraxaci 15g～20g、Rhizoma Smilacis Glabrae 10g～15g、Semen Arecae 10g～15g、Radix Et Rhizoma Rhei 10g～20g、Herba Asari 5g～10g、Cortex Moutan 15g～20g、Herba Menthae 10g～15g、Borneolum Syntheticum 10g～15g、Pseudobulbus Bletillae (Rhizoma Bletillae) 5g～15g、Radix Ampelopsis 5g～10g、Radix Trichosanthis 5g～10g、Bulbus Lilii 10g～20g、Radix Ophiopogonis 15g～25g、Herba Agrimoniae 10g～15g、Rhizoma Atractylodis 10g～15g、Semen Alpiniae Katsumadai 5g～10g、Herba Eupatorii 5g～10g、Herba Pogostemonis 10g～20g、Herba Dendrobii 5g～10g、Concha Ostreae (calcined) 5g～10g and Radix Glycyrrhizae 15g～25g.
nullWherein，The weight respectively Radix Scutellariae 30g～35g of each crude drug in described Chinese medicine compound extract component、Rhizoma Coptidis 35g～40g、Cortex Phellodendri 30g～35g、Radix Sophorae Flavescentis 15g～20g、Radix Scrophulariae 15g～20g、Flos Chrysanthemi Indici 15g～20g、Herba Lobeliae Chinensis 10g～15g、Herba Lophatheri 10g～15g、Flos Lonicerae 25g～30g、Herba Taraxaci 15g～20g、Rhizoma Smilacis Glabrae 10g～15g、Semen Arecae 10g～15g、Radix Et Rhizoma Rhei 15g～20g、Herba Asari 5g～10g、Cortex Moutan 15g～20g、Herba Menthae 10g～15g、Borneolum Syntheticum 10g～15g、Pseudobulbus Bletillae (Rhizoma Bletillae) 10g～15g、Radix Ampelopsis 5g～10g、Radix Trichosanthis 5g～10g、Bulbus Lilii 10g～15g、Radix Ophiopogonis 20g～25g、Herba Agrimoniae 10g～15g、Rhizoma Atractylodis 10g～15g、Semen Alpiniae Katsumadai 5g～10g、Herba Eupatorii 5g～10g、Herba Pogostemonis 10g～15g、Herba Dendrobii 5g～10g、Concha Ostreae (calcined) 5g～10g and Radix Glycyrrhizae 20g～25g.
Wherein, the weight respectively Radix Scutellariae 30g of each crude drug, Rhizoma Coptidis 40g, Cortex Phellodendri 30g, Radix Sophorae Flavescentis 20g, Radix Scrophulariae 20g, Flos Chrysanthemi Indici 15g, Herba Lobeliae Chinensis 15g, Herba Lophatheri 15g, Flos Lonicerae 25g, Herba Taraxaci 20g, Rhizoma Smilacis Glabrae 10g, Semen Arecae 10g, Radix Et Rhizoma Rhei 15g, Herba Asari 5g, Cortex Moutan 20g, Herba Menthae 15g, Borneolum Syntheticum 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Ampelopsis 5g, Radix Trichosanthis 10g, Bulbus Lilii 15g, Radix Ophiopogonis 20g, Herba Agrimoniae 10g, Rhizoma Atractylodis 10g, Semen Alpiniae Katsumadai 10g, Herba Eupatorii 5g, Herba Pogostemonis 15g, Herba Dendrobii 10g, Concha Ostreae (calcined) 5g and Radix Glycyrrhizae 20g in described Chinese medicine compound extract component.
The present invention provides a kind of Chinese medicine mouth wash, and its raw material includes above-mentioned Chinese medicine compound extract component, potassium sorbate, vitamin C, sucrose, citric acid stearoyl monoglyceride, sodium carboxymethyl cellulose, polyoxyethylene octadecanol, dodecyl sodium sulfate, second alcohol and water.
Wherein, the weight of each raw material respectively Chinese medicine compound extract component 50g～80g, potassium sorbate 2g～5g, vitamin C 1g～3g, sucrose 5g～8g, citric acid stearoyl monoglyceride 5g～8g, sodium carboxymethyl cellulose 4g～6g, polyoxyethylene octadecanol 2g～4g, dodecyl sodium sulfate 1g～3g, alcohol volumetric concentration is the ethanol 20g～40g of 80%, adds distilled water to 1000ml.
The preparation method that present invention also offers above-mentioned Chinese medicine mouth wash, comprising:
The first step, prepares above-mentioned Chinese medicine compound extract component；
Second step, takes Chinese medicine compound extract component prepared by the first step and mixs homogeneously with the isopyknic distilled water of ethanol and ethanol；
3rd step, mixs homogeneously remaining raw material components with appropriate water；
4th step, the mixed solution that the mixed solution obtain second step and the 3rd step obtain mixes further, stirs, adds distilled water and namely obtain collutory to 1000ml.
Wherein, the described first step is specially further and takes crude drug component by weight ratio, pulverize, mix, adding relative to mixture quality 6～10 times amount water, 100 DEG C are extracted 1～2 hour, filter, filtering residue adds relative to mixture quality 5～8 times amount water again, 100 DEG C are extracted 1～2 hour, filter, and filtrate merges, filtrate reduced in volume is to crude drug concentration 0.5-1g/mL, add the alcohol volumetric concentration 95% ethanol precipitation of equal volume amounts, filter, concentrating under reduced pressure, drying and crushing, it is thus achieved that Chinese medicine compound extract component.
Useful technique effect
Chinese medicine gargle provided by the invention is possible not only to effective Killing Candida Albicans, and contribute to recovering other colony balances of oral cavity, in addition, antifungal drug toxicity and drug resistance are bigger, and this medicine carries out medication according to the body constitution of patient, can reinforcing body resistance, anti-heresy is gone out, treating rapidly buccal cavity fungal infection, one characteristic of invention formulation is the dosage form adopting Chinese medicine gargle, it is possible to focal medication, rapid-onset, after avoiding oral administration medicament, fungus is entered by digestive tract internal, cause other to infect, there is very good application prospect.
Detailed description of the invention
The invention provides a kind of Chinese medicine compound extract component for preventing and treating buccal cavity fungal infection, its crude drug includes Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Scrophulariae, Flos Chrysanthemi Indici, Herba Lobeliae Chinensis, Herba Lophatheri, Flos Lonicerae, Herba Taraxaci, Rhizoma Smilacis Glabrae, Semen Arecae, Radix Et Rhizoma Rhei, Herba Asari, Cortex Moutan, Herba Menthae, Borneolum Syntheticum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Trichosanthis, Bulbus Lilii, Radix Ophiopogonis, Herba Agrimoniae, Rhizoma Atractylodis, Semen Alpiniae Katsumadai, Herba Eupatorii, Herba Pogostemonis, Herba Dendrobii, Concha Ostreae (calcined) and Radix Glycyrrhizae.
Although the traditional Chinese medical science is without buccal cavity fungal infection name of disease, but the understanding of fungal infection is had it long ago.Oral cavity monilial infection, fungal enteritis in doctor trained in Western medicine is known respectively as " thrush ", " having loose bowels " in the traditional Chinese medical science,
Oral cavity is the key of clear sun, likes clearly, only mechanism of qi protection lifting, and clear positive rising, turbid yin decline and could keep the cleaning in oral cavity.Damp mostly is YIN pathogen, has the effect checking ascending or descending movement of vital Qi, and The spleen has the function to transport and transform nutrients, and defeated cloth is precise and tiny, stomach receiving food and drink, digesting food, and in damp retardance, Jiao causes ascending or descending movement of vital Qi to lack of proper care；Add and get angry for YANG pathogen, in property inflammation, it is easy to injuring human body surface and close key, and oral cavity occupy, the fire of inflammatory will be assembled oral cavity and form this disease.But this disease most basic be weakened body resistance, be mainly reflected in the deficiency of vital energy and the deficiency of YIN.First from meridians angle, oral cavity belongs to spleen meridian, enters abdomen and belongs to spleen network stomach, eventually end ankyloglossia this, dissipate Sublingual.If deficiency of spleen-QI to insert the defeated cloth of water liquid uneven, in retardance, Jiao will result in that water is wet to be accumulate in mouth.And lung governing qi department breathes, main Xuan Fasu drops, and for source on water, deficiency of lung-YIN can cause a surname of lung to send out respectful to drop function reduction, and obstacle occurs in water liquid metabolism.So, the pathogenesis of buccal cavity fungal infection is vital QI being weakened and pathogen being violent, and therefore, its pattern of syndrome of dialectical analysis is deficiency of qi and yin, retention of damp-heat in the interior on pattern of syndrome.Boosting qi and nourishing yin, removing damp-heat are worked as in treatment, and parasite killing detoxifies.
Therefore Chinese medicine compound extract component of the present invention uses Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Scrophulariae dispelling the damp pathogen with drugs of bitter in taste and cold in nature, eliminating fire and detoxication, what the traditional Chinese medical science thought primary disease occurs as deficiency in origin and excess in superficiality, the deficiency of YIN is this, evil poison is mark, the raw interior-heat of the deficiency of YIN, evil poison accumulates and heat-transformation, therefore symptomatic treatment in acute condition, with the medicine of the bitter colds such as SANHUANG, two ginsengs, and modern medicine study finds, effective ingredient in Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, there is the effect well killing antibacterial, have good adjustment effect for intestinal microbial population balance, therefore combine for monarch drug；Radix Trichosanthis, Herba Dendrobii, Bulbus Lilii, Radix Ophiopogonis replenishing YIN and removing heat, Radix Glycyrrhizae invigorating the spleen and replenishing QI, reinforcing both QI and YIN, play the merit of strengthening the body resistance altogether, for ministerial drug group；Rhizoma Atractylodis, Semen Alpiniae Katsumadai, Herba Eupatorii, Herba Pogostemonis removing dampness by means of aromatics are kept away dirty, Herba Agrimoniae, Cortex Moutan clearing away heat and cooling blood, and Herba Agrimoniae priming enters blood system, wet in profit blood；Using Flos Chrysanthemi Indici, Herba Lobeliae Chinensis, Herba Lophatheri, Flos Lonicerae, Herba Taraxaci heat-clearing and toxic substances removing, coordinate the medicine such as Rhizoma Coptidis, Radix Sophorae Flavescentis, the fire that clear sun is bright, stomach-fire must be removed, and the fire unrooted of upper inflammation, then heresy contains to remove；In addition Rhizoma Smilacis Glabrae, Semen Arecae, Radix Et Rhizoma Rhei parasite killing intestinal stasis relieving are added, give evil in outlet, use Herba Asari, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Herba Menthae, Borneolum Syntheticum to have effect of cooling blood for hemostasis, clearing away heat to alleviate pain simultaneously, wherein the Pseudobulbus Bletillae (Rhizoma Bletillae) has the effect well promoting oral mucosa to repair, because full side is cooler, for preventing its property of medicine cold and cool, follow through injuring one's stomach, therefore add Concha Ostreae (calcined) Gu and protect taste, all medicines share, and make for assistant altogether.Comprehensive analysis, all formulas are matched, plays boosting qi and nourishing yin, dampness pathogenic fire purging, effect of parasite killing removing toxic substances altogether.Decrease a large amount of uses of western medicine antibiotics, recover body colony balance.
It is preferred that, described Chinese medicine compound extract component is only prepared from by above-mentioned raw materials medicine.
nullThe weight respectively Radix Scutellariae 25g～35g of each crude drug in described Chinese medicine compound extract component、Rhizoma Coptidis 30g～45g、Cortex Phellodendri 25g～35g、Radix Sophorae Flavescentis 15g～25g、Radix Scrophulariae 10g～25g、Flos Chrysanthemi Indici 10g～20g、Herba Lobeliae Chinensis 10g～20g、Herba Lophatheri 10g～20g、Flos Lonicerae 20g～30g、Herba Taraxaci 15g～20g、Rhizoma Smilacis Glabrae 10g～15g、Semen Arecae 10g～15g、Radix Et Rhizoma Rhei 10g～20g、Herba Asari 5g～10g、Cortex Moutan 15g～20g、Herba Menthae 10g～15g、Borneolum Syntheticum 10g～15g、Pseudobulbus Bletillae (Rhizoma Bletillae) 5g～15g、Radix Ampelopsis 5g～10g、Radix Trichosanthis 5g～10g、Bulbus Lilii 10g～20g、Radix Ophiopogonis 15g～25g、Herba Agrimoniae 10g～15g、Rhizoma Atractylodis 10g～15g、Semen Alpiniae Katsumadai 5g～10g、Herba Eupatorii 5g～10g、Herba Pogostemonis 10g～20g、Herba Dendrobii 5g～10g、Concha Ostreae (calcined) 5g～10g and Radix Glycyrrhizae 15g～25g.
nullIt is preferred that，The weight respectively Radix Scutellariae 30g～35g of each crude drug in described Chinese medicine compound extract component、Rhizoma Coptidis 35g～40g、Cortex Phellodendri 30g～35g、Radix Sophorae Flavescentis 15g～20g、Radix Scrophulariae 15g～20g、Flos Chrysanthemi Indici 15g～20g、Herba Lobeliae Chinensis 10g～15g、Herba Lophatheri 10g～15g、Flos Lonicerae 25g～30g、Herba Taraxaci 15g～20g、Rhizoma Smilacis Glabrae 10g～15g、Semen Arecae 10g～15g、Radix Et Rhizoma Rhei 15g～20g、Herba Asari 5g～10g、Cortex Moutan 15g～20g、Herba Menthae 10g～15g、Borneolum Syntheticum 10g～15g、Pseudobulbus Bletillae (Rhizoma Bletillae) 10g～15g、Radix Ampelopsis 5g～10g、Radix Trichosanthis 5g～10g、Bulbus Lilii 10g～15g、Radix Ophiopogonis 20g～25g、Herba Agrimoniae 10g～15g、Rhizoma Atractylodis 10g～15g、Semen Alpiniae Katsumadai 5g～10g、Herba Eupatorii 5g～10g、Herba Pogostemonis 10g～15g、Herba Dendrobii 5g～10g、Concha Ostreae (calcined) 5g～10g and Radix Glycyrrhizae 20g～25g.
Most preferably, the weight respectively Radix Scutellariae 30g of each crude drug, Rhizoma Coptidis 40g, Cortex Phellodendri 30g, Radix Sophorae Flavescentis 20g, Radix Scrophulariae 20g, Flos Chrysanthemi Indici 15g, Herba Lobeliae Chinensis 15g, Herba Lophatheri 15g, Flos Lonicerae 25g, Herba Taraxaci 20g, Rhizoma Smilacis Glabrae 10g, Semen Arecae 10g, Radix Et Rhizoma Rhei 15g, Herba Asari 5g, Cortex Moutan 20g, Herba Menthae 15g, Borneolum Syntheticum 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Ampelopsis 5g, Radix Trichosanthis 10g, Bulbus Lilii 15g, Radix Ophiopogonis 20g, Herba Agrimoniae 10g, Rhizoma Atractylodis 10g, Semen Alpiniae Katsumadai 10g, Herba Eupatorii 5g, Herba Pogostemonis 15g, Herba Dendrobii 10g, Concha Ostreae (calcined) 5g and Radix Glycyrrhizae 20g in described Chinese medicine compound extract component.
Invention formulation one characteristic is the dosage form adopting Chinese medicine gargle, it is possible to focal medication, rapid-onset, it is to avoid is entered by digestive tract internal by fungus after oral administration medicament, causes other to infect.
Based on this, the present invention provides a kind of Chinese medicine mouth wash, and its raw material includes Chinese medicine compound extract component, potassium sorbate, vitamin C, sucrose, citric acid stearoyl monoglyceride, sodium carboxymethyl cellulose, polyoxyethylene octadecanol, dodecyl sodium sulfate, second alcohol and water.
The volumetric concentration of ethanol is 60%～80%, it is preferred to 80% volumetric concentration.
The weight of each raw material respectively Chinese medicine compound extract component 50g～80g, potassium sorbate 2g～5g, vitamin C 1g～3g, sucrose 5g～8g, citric acid stearoyl monoglyceride 5g～8g, sodium carboxymethyl cellulose 4g～6g, polyoxyethylene octadecanol 2g～4g, dodecyl sodium sulfate 1g～3g, alcohol volumetric concentration is the ethanol 20g～40g of 80%, adds distilled water to 1000ml.
It is preferred that, the weight of each raw material respectively Chinese medicine compound extract component 60g, potassium sorbate 3g, Catergen g, sucrose 6g, citric acid stearoyl monoglyceride 6g, sodium carboxymethyl cellulose 5g, polyoxyethylene octadecanol 3g, dodecyl sodium sulfate 2g, alcohol volumetric concentration is the ethanol 30g of 80%, adds distilled water to 1000ml.
The preparation method that present invention also offers above-mentioned Chinese medicine mouth wash, comprising:
The first step, prepares above-mentioned Chinese medicine compound extract component；
Second step, takes Chinese medicine compound extract component prepared by the first step and mixs homogeneously with the isopyknic distilled water of ethanol and ethanol；
3rd step, mixs homogeneously remaining raw material components with appropriate water；
4th step, the mixed solution that the mixed solution obtain second step and the 3rd step obtain mixes further, stirs, adds distilled water and namely obtain collutory to 1000ml.
The preparation process of described Chinese medicine compound extract component is specially and takes crude drug component by weight ratio, pulverize, mix, add relative to mixture quality 6～10 times amount water, 100 DEG C are extracted 1～2 hour, filtering, filtering residue adds relative to mixture quality 5～8 times amount water again, and 100 DEG C are extracted 1～2 hour, filter, filtrate merges, and filtrate reduced in volume, to crude drug concentration 0.5-1g/mL, adds the alcohol volumetric concentration 95% ethanol precipitation of equal volume amounts, filter, concentrating under reduced pressure, drying and crushing, it is thus achieved that Chinese medicine compound extract component.
The crude drug that described Chinese medicine compound extract component adopts includes Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Scrophulariae, Flos Chrysanthemi Indici, Herba Lobeliae Chinensis, Herba Lophatheri, Flos Lonicerae, Herba Taraxaci, Rhizoma Smilacis Glabrae, Semen Arecae, Radix Et Rhizoma Rhei, Herba Asari, Cortex Moutan, Herba Menthae, Borneolum Syntheticum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Trichosanthis, Bulbus Lilii, Radix Ophiopogonis, Herba Agrimoniae, Rhizoma Atractylodis, Semen Alpiniae Katsumadai, Herba Eupatorii, Herba Pogostemonis, Herba Dendrobii, Concha Ostreae (calcined) and Radix Glycyrrhizae.
nullThe weight of each crude drug respectively Radix Scutellariae 25g～35g、Rhizoma Coptidis 30g～45g、Cortex Phellodendri 25g～35g、Radix Sophorae Flavescentis 15g～25g、Radix Scrophulariae 10g～25g、Flos Chrysanthemi Indici 10g～20g、Herba Lobeliae Chinensis 10g～20g、Herba Lophatheri 10g～20g、Flos Lonicerae 20g～30g、Herba Taraxaci 15g～20g、Rhizoma Smilacis Glabrae 10g～15g、Semen Arecae 10g～15g、Radix Et Rhizoma Rhei 10g～20g、Herba Asari 5g～10g、Cortex Moutan 15g～20g、Herba Menthae 10g～15g、Borneolum Syntheticum 10g～15g、Pseudobulbus Bletillae (Rhizoma Bletillae) 5g～15g、Radix Ampelopsis 5g～10g、Radix Trichosanthis 5g～10g、Bulbus Lilii 10g～20g、Radix Ophiopogonis 15g～25g、Herba Agrimoniae 10g～15g、Rhizoma Atractylodis 10g～15g、Semen Alpiniae Katsumadai 5g～10g、Herba Eupatorii 5g～10g、Herba Pogostemonis 10g～20g、Herba Dendrobii 5g～10g、Concha Ostreae (calcined) 5g～10g and Radix Glycyrrhizae 15g～25g.
nullIt is preferred that，The weight of each crude drug respectively Radix Scutellariae 30g～35g、Rhizoma Coptidis 35g～40g、Cortex Phellodendri 30g～35g、Radix Sophorae Flavescentis 15g～20g、Radix Scrophulariae 15g～20g、Flos Chrysanthemi Indici 15g～20g、Herba Lobeliae Chinensis 10g～15g、Herba Lophatheri 10g～15g、Flos Lonicerae 25g～30g、Herba Taraxaci 15g～20g、Rhizoma Smilacis Glabrae 10g～15g、Semen Arecae 10g～15g、Radix Et Rhizoma Rhei 15g～20g、Herba Asari 5g～10g、Cortex Moutan 15g～20g、Herba Menthae 10g～15g、Borneolum Syntheticum 10g～15g、Pseudobulbus Bletillae (Rhizoma Bletillae) 10g～15g、Radix Ampelopsis 5g～10g、Radix Trichosanthis 5g～10g、Bulbus Lilii 10g～15g、Radix Ophiopogonis 20g～25g、Herba Agrimoniae 10g～15g、Rhizoma Atractylodis 10g～15g、Semen Alpiniae Katsumadai 5g～10g、Herba Eupatorii 5g～10g、Herba Pogostemonis 10g～15g、Herba Dendrobii 5g～10g、Concha Ostreae (calcined) 5g～10g and Radix Glycyrrhizae 20g～25g.
Most preferably, the weight of each crude drug respectively Radix Scutellariae 30g, Rhizoma Coptidis 40g, Cortex Phellodendri 30g, Radix Sophorae Flavescentis 20g, Radix Scrophulariae 20g, Flos Chrysanthemi Indici 15g, Herba Lobeliae Chinensis 15g, Herba Lophatheri 15g, Flos Lonicerae 25g, Herba Taraxaci 20g, Rhizoma Smilacis Glabrae 10g, Semen Arecae 10g, Radix Et Rhizoma Rhei 15g, Herba Asari 5g, Cortex Moutan 20g, Herba Menthae 15g, Borneolum Syntheticum 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Ampelopsis 5g, Radix Trichosanthis 10g, Bulbus Lilii 15g, Radix Ophiopogonis 20g, Herba Agrimoniae 10g, Rhizoma Atractylodis 10g, Semen Alpiniae Katsumadai 10g, Herba Eupatorii 5g, Herba Pogostemonis 15g, Herba Dendrobii 10g, Concha Ostreae (calcined) 5g and Radix Glycyrrhizae 20g.
Radix Scutellariae: latin name ScutellariaeRadix, bitter in the mouth, cold in nature, enter the heart, lung, stomach, gallbladder, large intestine channel, have a heat clearing and damp drying, eliminating fire and detoxication, antiabortive, the effect of hemostasis, it is mainly used in damp and hot caused diarrhoea, dysentery, jaundice, pyretic stranguria；Cough due to lung-heat, thirsty pharyngalgia, it may also be used for excessive fetal movement due to heat in pregnancy, pyretic toxicity pathogenic fire invades the card that the carbuncle sore poison of excessive skin swells.
Rhizoma Coptidis: bitter in the mouth, cold in nature, enter the heart, lung, gallbladder, stomach, large intestine channel, have heat clearing and damp drying, eliminating fire and detoxication, the effect of cooling blood for improving eyesight, be usually used in the fire for the treatment of removing pathogen in the heart warp, the dysphoria and insomnia that heart-fire is prosperous, and the high fever coma of epidemic febrile disease, the symptom such as vexed, thirsty.
Cortex Phellodendri: latin name PhellodendriChinensisCortex, bitter in the mouth, cold in nature, enter kidney, bladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.The cards such as damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus, multiple gram-positive bacterium is had good antibacterial action by Cortex Phellodendri.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature, enter liver, kidney, large intestine, small intestinal, bladder, heart channel, there is heat clearing and damp drying, the effect of wind dispelling insecticide, cure mainly damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, leprosy, skin pruritus, noxious dampness skin infection etc. is demonstrate,proved.
Radix Scrophulariae: sweet in the mouth, hardship, one-tenth, cold nature, returns lung, stomach, kidney channel, there is clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing effect for nourishing kidney, cure mainly pathogenic warmth to join the army, cave in pericardium, maculae caused by violent heat pathogen, and the cards such as constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.
Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent, return lung, Liver Channel, there is effect of heat-clearing and toxic substances removing, dispelling wind suppressing the hyperactive liver, cure mainly furuncle, carbuncle, scrofula, erysipelas, eczema, scabies, anemopyretic cold, laryngopharynx swelling and pain, dizziness and headache, conjunctival congestion burning pain etc. is demonstrate,proved, Flos Chrysanthemi Indici, to staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all has inhibitory action.
Herba Lobeliae Chinensis: acrid in the mouth, property is put down, and GUIXIN, small intestinal, lung meridian have effect of heat-clearing and toxic substances removing, inducing diuresis to remove edema, cures mainly the cards such as snake bite and insect sting, jaundice due to damp-heat, eczema eczema, carbuncle furuncle.
Herba Lophatheri: sweet in the mouth, light, cold in nature, enter the heart, lung, stomach warp, have the effect of clearing heat and relieving fidgetness, inducing diuresis for treating stranguria syndrome, be mainly used in the cards such as fever caused by exogenous pathogenic factors, restlessness and thirst, heart stomach-fire Sheng, aphtha of the mouth and tongue, dark coloured urine stranguria with turbid discharge.
Flos Lonicerae: latin name loniceraejaponicaeflos, sweet in the mouth, cold in nature, enter the heart, lung, stomach, large intestine channel, have the effect of heat-clearing and toxic substances removing, holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is relatively contained, or when epidemic febrile disease is still not descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of pathogenic heat；Pyretic toxicity dysentery, stool hematochezia；Fever disease in summer is demonstrate,proved；The carbuncle sore that pyretic toxicity gathers from the beginning of, lift the card such as the heat person of swelling and ache.
Herba Taraxaci: latin name TaraxaciHerba, sweet in the mouth, hardship, cold in nature, enter liver, stomach warp, there is the effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, liver heat removing and eyesight improving, inducing diuresis for treating stranguria syndrome, it is mainly used in the treatment of sore swollen toxin, acute mastitis effect is especially notable, also can be used for the treatment of the symptoms such as the conjunctival congestion and swelling pain of flaming up of liver-fire, in addition, also there is the effect of promoting urination to remove dampness, for controlling the treatment of the diseases such as jaundice due to damp-heat, dysuria, urinary system infection.
Rhizoma Smilacis Glabrae: sweet in the mouth, light, property is put down, Liver Channel；Stomach warp；Spleen channel, has removing toxic substances, dehumidifying, the effect in profit joint, cures mainly syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, the cards such as furuncle treats skin ulcer, carbuncle, scrofula, syphilis and the limbs contracture caused by mercurialism, bones and muscles pain.
Semen Arecae: bitter in the mouth, pungent, warm in nature, return stomach, large intestine channel, there is parasite killing, removing food stagnancy, circulation of qi promoting, diuretic, effect of preventing the attack (or recurrence) of malaria, cure mainly abdominal pain due to worm stagnation, stagnant dysentery, tenesmus, edema beriberi, malaria etc. is demonstrate,proved, and Semen Arecae can promote gastrointestinal motility, improves the secretion of motilin and vasoactive intestinal peptide.
Radix Et Rhizoma Rhei: latin name RheiRadixetRhizoma, bitter in the mouth, cold in nature, return stomach warp；Large intestine channel；Liver Channel；Spleen channel, have attack stagnant；Clearing away damp-heat；Pathogenic fire purging；Removing heat from blood；Blood stasis dispelling；Effect of removing toxic substances, cures mainly excess-heat constipation；The accumulation of heat feeling of stuffiness in chest；Damp-heat dysentery；Jaundice；Gonorrhea；Edema abdominal distention；Dysuria；Conjunctival congestion；Laryngopharynx swelling and pain；Aphtha of the mouth and tongue；Gastropyretic vomiting；Spit blood；Spitting of blood；Epistaxis；Have blood in stool；Hematuria；Blood-retention；Amenorrhea；Puerperal the stagnant stomachache of the stasis of blood；Lump in the abdomen；Traumatic injury；Pyretic toxicity carbuncle and ulcer；Erysipelas；The cards such as scald.
Herba Asari: latin name AsariRadixetRhizoma, acrid in the mouth, warm in nature, return lung, kidney channel, there is expelling wind and cold pain relieving, effect that warming the lung to resolve fluid-retention is sensible, cure mainly affection of exogenous wind-cold, headache, toothache, wind and cold temperature numbness, affection of exogenous wind-cold, in stop lung cold cough with asthma caused by cold fluid-retention, nasal sinusitis of having a stuffy nose, wind-eye corneal nebula, deafness pharyngalgia, aphtha halitosis etc. is demonstrate,proved.
Cortex Moutan: latin name MoutanCortex, bitter in the mouth, pungent, cold nature, enter the heart, liver, kidney channel, have the effect of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, demonstrate,prove for the fever due to yin deficiency of excessive noxious heat, the acute appendicitis of damp and hot knot poison, depressed blood stasis, xerostomia, deep red tongue etc.；And liver-fire conjunctival congestion and swelling pain, stomach-fire gingiva pain.
Herba Menthae: acrid in the mouth, cool in nature, enters lung, Liver Channel, has effect of dispelling wind and heat pathogens, the clear profit head, sore-throat relieving rash, dispersing the stagnated live-QI to relieve the stagnation of QI, for affection due to external wind and heat or epidemic febrile disease from the beginning of, headache due to pathogenic wind-heat, the many tear of Ramulus et Folium Bischofiae Javanicae, laryngopharynx swelling and pain, measles without adequate eruption, rubella is scratched where it itches, irritability stasis, and uncomfortable in chest not relaxing waits card.
Borneolum Syntheticum: acrid in the mouth, hardship, cool in nature, GUIXIN, lung meridian, there is logical all keys, dissipate stagnated fire, removing nebula improving eyesight, effect of reducing swelling and alleviating pain, cure mainly apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, the cards such as order is nebula film also, enterobiasis.
The Pseudobulbus Bletillae (Rhizoma Bletillae): property is bitter, sweet, puckery, cold nature, enters lung, stomach, Liver Channel, has the effect of astringing to arrest bleeding, detumescence life, is mainly used in the haematemesis of the deficiency of the lung, pulmonary tuberculosis, the hemoptysis of yin asthenia generating intrinsic heat, thermal burn stomach network；Traumatic hemorrhage etc. are demonstrate,proved.
Radix Ampelopsis: latin name AmpelopsisRadix, bitter in the mouth, cold nature, GUIXIN, stomach warp, there is effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, expelling pus and promoting granulation, cure mainly the cards such as carbuncle carbuncle on the back, furuncle, burn and scald.
The cards such as Radix Trichosanthis: sweet in the mouth, micro-hardship, cold nature, enters lung, stomach warp, have clearing away heat and promoting production of body fluid, effect of detumescence and apocenosis, and for calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.
Bulbus Lilii: sweet in the mouth, cold nature, enter the heart, lung meridian, there is nourishing YIN and moistening the lung, effect of clearing away heart-fire for tranquillization, cure mainly deficiency of YIN chronic cough, sputum mixed with blood, the cards such as fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.
Radix Ophiopogonis: latin name OphiopogonisRadix, sweet in the mouth, micro-hardship, cold nature, enter the heart, lung, stomach warp, there is nourishing YIN and moistening the lung, effect that preventing phlegm from forming and stopping coughing, heat clearing away are nourished heart, cure mainly pathogenic dryness impairing the lung or lung-dryness syndrome due to deficiency of YIN has the dry cough expectorant of heat to stick, chronic cough hemoptysis, dry pharynx dryness in the nasal cavity, lung abscess, dry mouth and throat caused by thermal burn stomach-Yin or deficiency of stomach-Yin, the few tongue of red tongue, vague epigastralgia, interior-heat is quenched one's thirst, constipation due to dry stool, deficiency of heart-yin and epidemic febrile disease pathogenic heat are disturbed and the heart-nutriment and the dysphoria and insomnia that causes, crimson tongue and dry wait card.
Herba Agrimoniae: bitter in the mouth, puckery, property is put down, and GUIXIN, Liver Channel have astringing to arrest bleeding, effect of dysentery relieving parasite killing, cure mainly various hemorrhage card, for instance: haematemesiss, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, and wound hemorrhage etc. is demonstrate,proved.
Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature, return spleen, stomach, Liver Channel, have drying damp and strengthening spleen, expelling wind and dampness, effect of improving eyesight, cure mainly the bellyache and diarrhea profit of retention of dampness in middle-JIAO；Incoordination between the spleen and stomach, to epigastric pain, is vomitted indigestion and loss of appetite；The distending pain in the chest and hypochondrium of incoordination between the liver and stomach, vomiting with acid regurgitation etc. is demonstrate,proved.
Semen Alpiniae Katsumadai: acrid in the mouth, warm in nature, return spleen, stomach warp, there is effect of dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, cure mainly the cards such as internal retention of cold wetness, distension and fullness in the abdomen cold type of pain, belch vomiting, anorexia.
Herba Eupatorii: acrid in the mouth, property is put down, and returns spleen, stomach, lung meridian, has expelling summer-heat and damp, ward off dirty and in effect, cure mainly heat-damp in summer, cold and heat are had a headache, and accumulate in moistening, and gastral cavity painful abdominal mass is not hungry, nausea and vomiting, sweet greasy in mouth, disappear and truly wait card.
Herba Pogostemonis: acrid in the mouth, slightly warm in nature, return lung, spleen, stomach warp, there is dispelling summer-heat from superficies of the body, effect of removing dampness to restore normal function of the stomach.Catching a cold for the summertime, cold and heat are had a headache, and breast gastral cavity painful abdominal mass is vexed, and vomiting is had loose bowels, vomiting during pregnancy, nasal sinusitis, and hands, tinea pedis etc. are demonstrate,proved.
Herba Dendrobii: latin name DendrobiiCaulis, cold nature, sweet in the mouth, returns stomach, kidney channel, has reinforcing stomach reg fluid, effect of nourishing YIN and clearing away heat, cures mainly cloudy impairment of body fluid and loses, xerostomia excessive thirst, the cards such as lack of appetite is retched, deficiency-heat after being ill, poor vision.
Concha Ostreae (calcined): sweet in the mouth is put down, and enters the heart, Liver Channel, kidney channel, large intestine channel, Concha Ostreae (calcined) has tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, and stop blooding astringing intestine to stop diarrhea, the effect of promoting tissue regeneration and ulcer healing.Demented with controlling infantile convulsion, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, stranguria with turbid discharge of passing out semen, and tells nosebleed and has blood in stool, and bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.
Radix Glycyrrhizae: latin name GlycyrrhizaeRadixetRhizoma, sweet in the mouth, property is put down, and enters 12 warps, has a heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, be mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak；Alleviating contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralize by adding Radix Glycyrrhizae, is in harmonious proportion the work of each component.
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine compound extract component
nullTake Radix Scutellariae 30g、Rhizoma Coptidis 40g、Cortex Phellodendri 30g、Radix Sophorae Flavescentis 20g、Radix Scrophulariae 20g、Flos Chrysanthemi Indici 15g、Herba Lobeliae Chinensis 15g、Herba Lophatheri 15g、Flos Lonicerae 25g、Herba Taraxaci 20g、Rhizoma Smilacis Glabrae 10g、Semen Arecae 10g、Radix Et Rhizoma Rhei 15g、Herba Asari 5g、Cortex Moutan 20g、Herba Menthae 15g、Borneolum Syntheticum 15g、Pseudobulbus Bletillae (Rhizoma Bletillae) 10g、Radix Ampelopsis 5g、Radix Trichosanthis 10g、Bulbus Lilii 15g、Radix Ophiopogonis 20g、Herba Agrimoniae 10g、Rhizoma Atractylodis 10g、Semen Alpiniae Katsumadai 10g、Herba Eupatorii 5g、Herba Pogostemonis 15g、Herba Dendrobii 10g、Concha Ostreae (calcined) 5g and Radix Glycyrrhizae 20g，Pulverize，Mix，Add 3.8kg water，100 DEG C are extracted 2 hours，Filter，Filtering residue adds 2.8kg water again，100 DEG C are extracted 2 hours，Filter，Filtrate merges，Filtrate reduced in volume is to crude drug concentration 1g/mL，Add the alcohol volumetric concentration 95% ethanol precipitation of equal volume amounts，Filter，Concentrating under reduced pressure，Drying and crushing，Obtain Chinese medicine compound extract component.
Embodiment 2 collutory
Chinese medicine compound extract component 60g, potassium sorbate 3g, Catergen g, sucrose 6g, citric acid stearoyl monoglyceride 6g, sodium carboxymethyl cellulose 5g, polyoxyethylene octadecanol 3g, dodecyl sodium sulfate 2g, alcohol volumetric concentration is the ethanol 30g of 80%, adds distilled water to 1000ml.
Example 1 preparation Chinese medicine compound extract component 60g and the ethanol 30g of alcohol volumetric concentration 80% and mix homogeneously with the isopyknic distilled water of ethanol, by potassium sorbate 3g, Catergen g, sucrose 6g, citric acid stearoyl monoglyceride 6g, sodium carboxymethyl cellulose 5g, polyoxyethylene octadecanol 3g, the water mix homogeneously of dodecyl sodium sulfate 2g and 200ml, the mixed solution of above-mentioned acquisition is stirred, adds distilled water and namely obtain collutory to 1000ml.
Being collutory dosage form during Clinical practice of the present invention, its action pathway is buccal absorption and few some drugs absorbs with digestive tract, passes through literature research, by maximum dose, the anxious toxicity research of simulation, adopt gastric infusion, to verify its safety, therefore carry out following anxious toxicity and long term toxicity research.
Chinese medicine preparation toxicological experiment of the present invention is studied
Chinese medicine preparation prescription of the present invention is as follows: Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Scrophulariae, Flos Chrysanthemi Indici, Herba Lobeliae Chinensis, Herba Lophatheri, Flos Lonicerae, Herba Taraxaci, Rhizoma Smilacis Glabrae, Semen Arecae, Radix Et Rhizoma Rhei, Herba Asari, Cortex Moutan, Herba Menthae, Borneolum Syntheticum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Trichosanthis, Bulbus Lilii, Radix Ophiopogonis, Herba Agrimoniae, Rhizoma Atractylodis, Semen Alpiniae Katsumadai, Herba Eupatorii, Herba Pogostemonis, Herba Dendrobii, Concha Ostreae (calcined) and Radix Glycyrrhizae.Specify according to state-promulgated pharmacopoeia and local medicinal herbal, Chinese medicine preparation of the present invention is without the contrary restriction or checking relation in five elements of compatibility, wherein would be likely to occur the Chinese medicine of toxicity and untoward reaction and have Herba Lobeliae Chinensis, Semen Arecae, Herba Asari, according to Chinese medicine preparation optimum combination of the present invention, Herba Lobeliae Chinensis consumption is 15g, Semen Arecae consumption is 10g, Herba Asari consumption is 5g, full side gross weight is 465g, according to process for preparing medicine, final preparation 1000ml collutory, using method according to clinical collutory, the collutory content of each Herba Lobeliae Chinensis is 0.75g/ time, getting rid of bulky collutory content is 0.5g/ time, the collutory content of Herba Asari is 0.25g/ time, it is below pharmacopeia using dosage, therefore it is safe.Now carry out anxious toxicity and long term toxicity research.
Pharmacology's acute toxicity test
Laboratory animal: SPF level, kunming mice, 80,28～30g, male and female half and half, Shandong Traditional Chinese Medicine University's animal experimental center provide, animal quality certification SCXK (Shandong) 2014-0261.
Test medicine
Experimental group: the Chinese medicine mouth wash 1 of embodiment 2 preparation, the solution that crude drug content is 1.55g/ml is prepared in concentration, and 4 DEG C save backup.
Matched group: gavage normal saline.
Experimental technique
Packet
Taking SPF level, kunming mice 80, male and female half and half, raise in Shandong Traditional Chinese Medicine University's animal experimental center, adaptability is raised one week.By table of random numbers method, mice is divided into 2 groups, is matched group 40 respectively, experimental group 40, male and female half and half, sub-cage rearing.
Medication
Before experiment, water 12h is can't help in the mice fasting of each group, matched group gavage distilled water 0.1ml/10g body weight, 3 times/day, experimental group, the Chinese medicine mouth wash after gavage present invention concentration, 0.1ml/10g body weight, 3 times/day, dosing interval 4h.Successive administration 7 days, drug withdrawal is observed 3 days.
Observation index
Observing during administration and during drug withdrawal observation, each ordinary circumstance organizing mice, such as developmental state (body temperature, body weight, heart rate), coat condition, the mental status, each natural hole situation, autonomic activities situation.
According to requirement of experiment, animal dead occurs during administration, dissects immediately, observe each internal organs situation, peel off each internal organs, weigh, and calculate organ index, heart extracting blood Physico-chemical tests；As without dead, then according to requirement of experiment, after the observation period, given 10% chloral hydrate anesthesia, open abdominal cavity, observe each internal organs situation, abdominal aortic blood is put to death, and does Physico-chemical tests, peels off each internal organs, weigh, and calculate organ index.
Result
Without dead mouse during experiment, carry out coherent detection according to experimental establishment.
During administration and during drug withdrawal observation, each group mice is at the baseline signs such as body weight, body temperature, Non Apparent Abnormality, and two groups are compared, no difference of science of statistics, outward appearance is normal, and without deformity, fur color and luster is normal, and the mental status is good, each natural hole is clean, secretions without exception, and autonomic activities is normal, behavior without exception.
According to requirement of experiment, after the observation period, giving 10% chloral hydrate anesthesia, abdominal aortic blood is put to death, opening abdominal cavity, observe each internal organs situation, each group mice organs arrangement is normal, without adhesion, without hemorrhage, taken blood does Physico-chemical tests, each group Mouse Blood routine is without exception, and liver function, kidney merit check without exception, peel off each internal organs, weigh, calculate organ index, through statistical analysis, no difference of science of statistics, two groups of same periods compare, statistics zero difference.
Conclusion
Pass through acute toxicity test in mice, mice dosage is 46.5g/kg/d, it is converted into adult normal dosage 465g/kg/d (mice and 60kg health adult conversion coefficient are 10), for 116.25 times (normal 60kg adult's Chinese medicine intake is 4g/kg/d) that adult normal daily measures, it is generally believed that in zoopery, be administered as people more than 100 times, and without obvious toxic-side effects, it is believed that medicine is safe.Can be confirmed by this experiment, whole Chinese medicine gargle of the present invention is wrongly taken according to simulation clinic, without acute toxic reaction, without delayed toxicity, therefore can indirectly confirm, the clinical administrated method pressing collutory, it is effectively less than this experiment acute toxicity test, it is understood that routine use Chinese medicine gargle of the present invention is safe, therefore Clinical practice is safe.
Mice long term toxicity test of the present invention
Laboratory animal: with anxious toxicity test.
Test medicine
Experimental group: the Chinese medicine mouth wash 1 of embodiment 2 preparation, the solution that crude drug content is 1.0g/ml, 0.75g/ml, 0.5g/ml is prepared in concentration, and 4 DEG C save backup.
Matched group: gavage normal saline.
Experimental technique
Packet
Taking SPF level, kunming mice 80, male and female half and half, raise in Shandong Traditional Chinese Medicine University's animal experimental center, adaptability is raised one week.By table of random numbers method, mice is divided into 4 groups, is matched group 20, high dose group 20, middle dosage group 20, low dose group 20 respectively, male and female half and half, sub-cage rearing.
Medication
Before experiment, water 12h, matched group gavage distilled water 0.1ml/20g body weight are can't help in the mice fasting of each group, 2 times/day, high, medium and low dosage group, gavage adjusts Chinese medicine mouth wash 1.0g/ml, 0.75g/ml, 0.5g/ml of the present invention of concentration respectively, 0.2ml/20g body weight, 2 times/day, dosing interval 6h.Successive administration 14 days, drug withdrawal is observed 7 days.
Observation index
Same acute toxicity test.
Result
Without dead mouse during experiment, carry out coherent detection according to experimental establishment.
During administration and during drug withdrawal observation, each group mice is at the baseline signs such as body weight, body temperature, Non Apparent Abnormality, and two groups are compared, no difference of science of statistics, outward appearance is normal, and without deformity, fur color and luster is normal, and the mental status is good, each natural hole is clean, secretions without exception, and autonomic activities is normal, behavior without exception.
According to requirement of experiment, after the observation period, giving 10% chloral hydrate anesthesia, abdominal aortic blood is put to death, opening abdominal cavity, observe each internal organs situation, each group mice organs arrangement is normal, without adhesion, without hemorrhage, taken blood does Physico-chemical tests, each group Mouse Blood routine is without exception, and liver function, kidney merit check without exception, peel off each internal organs, weigh, calculate organ index, through statistical analysis, no difference of science of statistics, two groups of same periods compare, statistics zero difference.
Conclusion
By mice long term toxicity test, mice dosage is 20g/kg/d, 15g/kg/d, 10g/kg/d, it is converted into adult normal dosage 200g/kg/d, 150g/kg/d, 100g/kg/d, 50 times daily measured for adult normal, 37.5 again, 25 times, can be confirmed by this experiment, whole Chinese medicine gargle of the present invention is wrongly taken according to simulation clinic, without acute toxic reaction, without delayed toxicity, therefore can indirectly confirm, the clinical administrated method pressing collutory, it is effectively less than this experiment long term toxicity test, it can be considered that, it is daily that to take Chinese medicine mouth wash of the present invention be safe, therefore Clinical practice is safe.
Embodiment 4 clinical and experimental study
Oral candidiasis (oralCandidasis) is fungus) disease of cari oris mucosa caused by candida infection.In recent years, due to the extensive use clinically of antibiotic and immunosuppressant, occurring dysbacteriosis or immunity to reduce and make internal organs, skin, mucosa fungal infection person increasing, the oidiomycotic incidence rate of oral mucosa and relapse rate also increase therewith.
Physical data
Select go to a doctor in January, 2014～2015 year January, meet buccal cavity fungal infection person 313 example, wherein male 157 example, women 156 example, 19～75 years old age, 47.5 years old mean age, the course of disease 13～29 days.313 example patients, according to including order, give and numbering, odd number is classified as treatment group, even numbers is classified as matched group, and two groups of patients are at sex, age, the course of disease, infection conditions and other ordinary circumstance no difference of science of statistics, and rejecting other severe disease affects primary disease treatment, final treatment group 144 example, matched group 148 example.Examinee checks through health check-up and pathology smear before treating, find candida albicans mycelia, clinical diagnosis is buccal cavity fungal infection person, and all cases is all without the pure oral mucosal injury of the disease damage such as skin, intestinal, disease damage is confined to the positions such as buccal mucosa, back portion, lip, bicker and gingiva.
Therapeutic Method
Treatment group: give and the Chinese medicine gargle 1 of the embodiment of the present invention 2 preparation, take 50ml, warm water is to 200ml, and mixing, every day is early, middle and late gargles, and in gargling latter 0.5 hour, water is prohibited in fasting.
Matched group: give and nystatin glycerite, preparation method is as follows: remove Nysfungin (1,000,000 unit), it is ground into powder, the ratio of glycerol adding 20ml (i.e. glycerin 1) mixes, every day is early, middle and late smears oral cavity disease sites, is administered in latter 0.5 hour fasting and prohibits water.
Two groups of patient's checks in 3 months all after the treatment, evaluate curative effect.
Curative effect determinate standard
Recovery from illness: the skin in bicker district and mucosa, without being chapped from the cold, close on skin with mucosa without hyperemia, without rotten to the corn and exudate, without pain or hemorrhage when dehiscing.
Take a turn for the better: the skin in bicker district and mucosa are chapped from the cold and alleviate, close on skin and alleviate with mucosa hyperemia, rotten to the corn and exudate basic absorption, pain relief or substantially without hemorrhage when dehiscing.
Invalid: bilateral is suffered from, the skin in bicker district and mucosa are chapped, and contiguous skin is congested with mucosa, and often there are erosion and exudate in the place of chapping, or has thin crust, pain or hemorrhage when dehiscing.
Result
Two groups of comparitive study, result is in Table 1.
1 liang of table group Comparison of therapeutic (example, %)
Group N Recovery from illness Take a turn for the better Invalid Effective percentage %
Treatment group 144 48* 85 11 92.36*
Matched group 148 13 96 39 73.65
Compare with matched group,*P < 0.05.
Two groups of patients after 3 months relapse rate and satisfaction rate compare, result is in Table 2.
2 liang of table group patient after 3 months relapse rate and satisfaction rate compare
Compare with matched group,*P < 0.05
Conclusion
By Chinese medicine mouth wash clinical observation of the present invention, there is the buccal cavity fungal infection situation that well suppresses, promote oral mucosa healing, with the comparative study of control drug nystatin sheet, Chinese medicine gargle curative effect of the present invention is better than control drug, and using method is easy, low price, and without influence on other colony balances, therefore Chinese medicine compound extract component of the present invention has good curative effect, it is adaptable to clinical expansion.
Embodiment 5 experimentation
Buccal cavity fungal infection, belongs to mycotic infection of superficial part, very common in clinic, and this kind of Pseudomonas candidiasis, candida pseudotropicalis in the candidiasis of Cryptococcaeceae, height, wherein Candida albicans is topmost pathogen.In order to verify the effect always for Candida albicans of Chinese medicine compound extract component in collutory of the present invention and compound recipe thereof, and studying the inhibitory action of its other floras for being likely to secondary infection in oral cavity, spy carries out the antifungal experimentation of Chinese medicine and compound recipe thereof.
Materials and methods
Strain: take pathomycete clinical separation strain: Candida albicans, silk bacterium, mucormycosis.
Bacterium solution preparation: put in right amount in physiological saline solution with inoculation hook picking, gently grind to form suspension, regulating bacterial concentration on blood cell counting plate is 5 × 105CFU/ml。
Prepare medicinal liquid: Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Scrophulariae, Flos Chrysanthemi Indici, Herba Lobeliae Chinensis, Herba Lophatheri, Flos Lonicerae, Herba Taraxaci, Rhizoma Smilacis Glabrae, Semen Arecae, Radix Et Rhizoma Rhei, Herba Asari, Cortex Moutan, Herba Menthae, Borneolum Syntheticum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Trichosanthis, Bulbus Lilii, Radix Ophiopogonis, Herba Agrimoniae, Rhizoma Atractylodis, Semen Alpiniae Katsumadai, Herba Eupatorii, Herba Pogostemonis, Herba Dendrobii, Concha Ostreae (calcined), Radix Glycyrrhizae, each 50g, add water 200～300ml by each medicine (except mineral drug), boil 15min, medicine juice gauze is leached.Add water 200～300ml, with method decoction filtering.The medicine juice endured out for twice is converted together, and heating concentration is 50ml；Respectively add water 50ml by 3 kinds of mineral drugs, namely prepares 100% medicinal liquid.
Other reagent instrument: distilled water, peptone, glucose, agar, chloromycetin, test tube, sample injector, autoclave sterilizer, calorstat, microscope, microbalance, 20ml syringe, 5ml syringe etc. are provided by laboratory.
Single medicinal material experimental technique: the conventional sabouraud's agar of preparation, adds in series test tube, often pipe 4ml.Take 140, be 1～140 pipe.Extract 100% medicinal liquid 2ml with 5ml syringe and add test tube 1ml, namely prepare 20% medicinal liquid culture medium mixture；Extracting distilled water 1ml in the 5ml syringe of residue 1ml medicinal liquid, mixing adds next test tube 1ml, namely prepares 10% medicinal liquid culture medium mixture.
So repeatedly, namely prepare 20%, 10%, 5%, 2.5%, 1.25%, 0.625%, 0.3125% medicine series concentration liquid culture medium mixture, carry out labelling simultaneously.Separately take 2, i.e. 141,142 pipe, add distilled water 1ml, carry out labelling simultaneously, amount to 142.After 115 pounds of high-pressure high-temperature sterilization 15min of autoclave sterilizer, put inclined-plane, to be cooled, namely prepare medicine series concentration cultures and control medium.Manage 1～140, strain to be tested inoculated by 141 pipes (growth control), and with 142 pipes, (blank) puts 25e calorstat 2 weeks together, observes fungus growing state.Bacterium is entirely without growth "-", bacterium hypoevolutism, and the bacterium colony of formation is less " 1+ ", and bacterium grows not vigorous " 2+ ", and bacterium grows more vigorous, but bacterium colony ratio normal less " 3+ ", bacterium blastoprolepsis vigorous " 4+ ".Minimum fungus is the least concentration (MIC) suppressing fungus growth entirely without growth concentration.
Compound recipe experimental technique: the Chinese medicine compound embodiment of the present invention 1 prepared extracts composition 1, according to cell experiment requirement, inoculates the same single medicinal material of strain, observes colony growth situation.
Result
Table 3 unit Chinese medicine and compound recipe MIC value %
Conclusion
Shown in upper table, in Chinese medicine compound extract component of the present invention, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Rhizoma Atractylodis, Semen Alpiniae Katsumadai, Herba Eupatorii, Herba Pogostemonis, Concha Ostreae (calcined) have the effect well suppressing oral Candida, all formulas are matched, its minimum effective dose is significantly lower than each single drug dose, therefore can drawing, Chinese medicine gargle prescription compatibility of the present invention has the effect of good vitro inhibition fungus, it is adaptable to clinical development.
All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement and/or the new method that limit other forms.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But, all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, and any those skilled in the art are changed or be modified as the Equivalent embodiments of equivalent variations possibly also with the technology contents of the disclosure above.But every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and remodeling that above example is made by the technical spirit of the present invention, still fall within the protection domain of technical solution of the present invention.

Claims (8)

1. the Chinese medicine compound extract component being used for preventing and treating buccal cavity fungal infection, it is characterised in that: crude drug includes Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Scrophulariae, Flos Chrysanthemi Indici, Herba Lobeliae Chinensis, Herba Lophatheri, Flos Lonicerae, Herba Taraxaci, Rhizoma Smilacis Glabrae, Semen Arecae, Radix Et Rhizoma Rhei, Herba Asari, Cortex Moutan, Herba Menthae, Borneolum Syntheticum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Radix Trichosanthis, Bulbus Lilii, Radix Ophiopogonis, Herba Agrimoniae, Rhizoma Atractylodis, Semen Alpiniae Katsumadai, Herba Eupatorii, Herba Pogostemonis, Herba Dendrobii, Concha Ostreae (calcined) and Radix Glycyrrhizae.
null2. the Chinese medicine compound extract component for preventing and treating buccal cavity fungal infection as claimed in claim 1，It is characterized in that: the weight of each crude drug respectively Radix Scutellariae 25g～35g、Rhizoma Coptidis 30g～45g、Cortex Phellodendri 25g～35g、Radix Sophorae Flavescentis 15g～25g、Radix Scrophulariae 10g～25g、Flos Chrysanthemi Indici 10g～20g、Herba Lobeliae Chinensis 1Og～20g、Herba Lophatheri 10g～20g、Flos Lonicerae 20g～30g、Herba Taraxaci 15g～20g、Rhizoma Smilacis Glabrae 10g～15g、Semen Arecae 10g～15g、Radix Et Rhizoma Rhei 10g～20g、Herba Asari 5g～10g、Cortex Moutan 15g～20g、Herba Menthae 10g～15g、Borneolum Syntheticum 10g～15g、Pseudobulbus Bletillae (Rhizoma Bletillae) 5g～15g、Radix Ampelopsis 5g～10g、Radix Trichosanthis 5g～10g、Bulbus Lilii 10g～20g、Radix Ophiopogonis 15g～25g、Herba Agrimoniae 10g～15g、Rhizoma Atractylodis 10g～15g、Semen Alpiniae Katsumadai 5g～10g、Herba Eupatorii 5g～10g、Herba Pogostemonis 10g～20g、Herba Dendrobii 5g～1Og、Concha Ostreae (calcined) 5g～10g and Radix Glycyrrhizae 15g～25g.
null3. the Chinese medicine compound extract component for preventing and treating buccal cavity fungal infection as claimed in claim 1 or 2，It is characterized in that: the weight of each crude drug respectively Radix Scutellariae 30g～35g、Rhizoma Coptidis 35g～40g、Cortex Phellodendri 30g～35g、Radix Sophorae Flavescentis 15g～20g、Radix Scrophulariae 15g～20g、Flos Chrysanthemi Indici 15g～20g、Herba Lobeliae Chinensis 10g～15g、Herba Lophatheri 10g～15g、Flos Lonicerae 25g～30g、Herba Taraxaci 15g～20g、Rhizoma Smilacis Glabrae 10g～15g、Semen Arecae 10g～15g、Radix Et Rhizoma Rhei 15g～20g、Herba Asari 5g～10g、Cortex Moutan 15g～20g、Herba Menthae 10g～15g、Borneolum Syntheticum 10g～15g、Pseudobulbus Bletillae (Rhizoma Bletillae) 1Og～15g、Radix Ampelopsis 5g～10g、Radix Trichosanthis 5g～10g、Bulbus Lilii 1Og～15g、Radix Ophiopogonis 20g～25g、Herba Agrimoniae 10g～15g、Rhizoma Atractylodis 1Og～15g、Semen Alpiniae Katsumadai 5g～10g、Herba Eupatorii 5g～10g、Herba Pogostemonis 10g～15g、Herba Dendrobii 5g～10g、Concha Ostreae (calcined) 5g～10g and Radix Glycyrrhizae 20g～25g.
4. the Chinese medicine compound extract component for preventing and treating buccal cavity fungal infection as described in claims 1 to 3, it is characterized in that: the weight of each crude drug respectively Radix Scutellariae 30g, Rhizoma Coptidis 40g, Cortex Phellodendri 30g, Radix Sophorae Flavescentis 20g, Radix Scrophulariae 20g, Flos Chrysanthemi Indici 15g, Herba Lobeliae Chinensis 15g, Herba Lophatheri 15g, Flos Lonicerae 25g, Herba Taraxaci 20g, Rhizoma Smilacis Glabrae 10g, Semen Arecae 10g, Radix Et Rhizoma Rhei 15g, Herba Asari 5g, Cortex Moutan 20g, Herba Menthae 15g, Borneolum Syntheticum 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Ampelopsis 5g, Radix Trichosanthis 10g, Bulbus Lilii 15g, Radix Ophiopogonis 20g, Herba Agrimoniae 10g, Rhizoma Atractylodis 10g, Semen Alpiniae Katsumadai 10g, Herba Eupatorii 5g, Herba Pogostemonis 15g, Herba Dendrobii 10g, Concha Ostreae (calcined) 5g and Radix Glycyrrhizae 20g.
5. a Chinese medicine mouth wash, it is characterised in that: raw material includes the Chinese medicine compound extract component described in Claims 1-4, potassium sorbate, vitamin C, sucrose, citric acid stearoyl monoglyceride, sodium carboxymethyl cellulose, polyoxyethylene octadecanol, dodecyl sodium sulfate, second alcohol and water.
6. Chinese medicine mouth wash as claimed in claim 5, it is characterized in that: the weight of each raw material respectively Chinese medicine compound extract component 50g～80g, potassium sorbate 2g～5g, vitamin C 1g～3g, sucrose 5g～8g, citric acid stearoyl monoglyceride 5g～8g, sodium carboxymethyl cellulose 4g～6g, polyoxyethylene octadecanol 2g～4g, dodecyl sodium sulfate 1g～3g, alcohol volumetric concentration is the ethanol 20g～40g of 80%, adds distilled water to 1000ml.
7. the preparation method of Chinese medicine mouth wash described in claim 5 or 6, it is characterised in that including:
The first step, prepares described Chinese medicine compound extract component；
Second step, takes Chinese medicine compound extract component prepared by the first step and mixs homogeneously with the isopyknic distilled water of ethanol and ethanol；
3rd step, mixs homogeneously remaining raw material components with appropriate water；
4th step, the mixed solution that the mixed solution obtain second step and the 3rd step obtain mixes further, stirs, adds distilled water and namely obtain collutory to 1000ml.
8. the preparation method of Chinese medicine mouth wash as claimed in claim 7, it is characterized in that: the described first step is specially further and takes crude drug component by weight ratio, pulverize, mix, add relative to mixture quality 6～10 times amount water, 100 DEG C are extracted 1～2 hour, filter, filtering residue adds relative to mixture quality 5～8 times amount water again, 100 DEG C are extracted 1～2 hour, filter, filtrate merges, filtrate reduced in volume is to crude drug concentration 0.5-1g/mL, add the alcohol volumetric concentration 95% ethanol precipitation of equal volume amounts, filter, concentrating under reduced pressure, drying and crushing, obtain Chinese medicine compound extract component.
CN201610285763.4A 2016-05-03 2016-05-03 Chinese herbal mouthwash for treating fungal infection of oral cavity Pending CN105770679A (en)

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CN106691956A (en) * 2016-12-01 2017-05-24 李妍 Anti-inflammatory and bacteriostatic mouthwash
CN106943524A (en) * 2017-04-12 2017-07-14 肖志远 A kind of Chinese medicine mouth wash for alleviating swelling and aching of gum
CN107174566A (en) * 2016-11-08 2017-09-19 黄秀芳 Clean the teeth sterilization flavouring multipurpose gargle

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CN107174566A (en) * 2016-11-08 2017-09-19 黄秀芳 Clean the teeth sterilization flavouring multipurpose gargle
CN106691956A (en) * 2016-12-01 2017-05-24 李妍 Anti-inflammatory and bacteriostatic mouthwash
CN106943524A (en) * 2017-04-12 2017-07-14 肖志远 A kind of Chinese medicine mouth wash for alleviating swelling and aching of gum

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