CN105770669A

CN105770669A - Medicinal preparation for treating colour spots and application thereof

Info

Publication number: CN105770669A
Application number: CN201610134089.XA
Authority: CN
Inventors: 王盛梅
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-03-09
Filing date: 2016-03-09
Publication date: 2016-07-20
Also published as: CN106421590A

Abstract

The invention relates to a medicinal preparation for treating colour spots and application thereof. The medicinal preparation contains mulberries, lotus leaves, decumbent corydalis tubers, alpinia oxyphylla, lagotis brevituba maxim, ricepaper pith, bile arisaema, pearl powder, golden cypress, ficus carica, discolor cinquefoil herbs, folium artemisiae argyi, licorice roots, red-rooted salvia roots, pomelo peel, aloe, chingma abutilon seeds, ladybell roots, astragalus membranaceus and tribulus terrestris. The medicinal preparation provided by the invention can inhibit the activity of tyrosinase, promote decomposition of melanin, improve microcirculation and effectively inhibit the growth of harmful organisms such as viruses and fungi, can also improve the sensitivity of skin to ultraviolet rays, and has the effects of growing skin and polishing colour; the medicines in the medicinal preparation are combined for use to achieve the effects of activating blood, promoting the circulation of qi, nourishing blood, and removing spots, and treat both manifestation and root causes of the colour spots; the recurrence rate is low after the colour spots are cured; moreover, the medicinal preparation is convenient to use and convenient to popularize and apply, and has no toxic or side effect.

Description

A kind of for pharmaceutical preparation treating mottle and application thereof

Technical field

The present invention relates to for medicine treating mottle and application thereof, particularly to a kind of for pharmaceutical preparation treating mottle and application thereof, belong to field of medicaments.

Background technology

Change along with environment for human survival, various diseases emerge in an endless stream, skin diseases increasingly enjoys the concern of people, mottle is exactly the one in dermatosis, has a strong impact on the external health of the mankind from Modern Aesthetics angle, and its appearance brings serious adverse effect to aspects such as the life of people, work, emotions, generally speaking, mottle refers to the speckle different with ambient color, including freckle, black speck, chloasma and senile plaque etc., belongs to dyschromicum dermatosis.A kind of common face formed due to the increase of dermal melanin is brown or melanin pigmentation, damages the dermatosis of capacitive, is mainly in buccal and forehead position, Exposure to Sunlight postemphasis, is more common in women, relevant with menoxenia pregnant, long-term.Mottle claims chloasma, is commonly called as " butterfly spot ", " chloasma hepaticum " or " cyasma ".For the patch of the brown of obscure boundary Chu or black, it mostly is symmetry.The appearance of mottle is most relevant with endocrine, especially relevant with the estrogen level of women, menoxenia, gestation, takes contraceptive or liver function is bad and chronic nephropathy is all likely to occur mottle, especially chloasma.

For mottle, occurring serious skewness weighing apparatus phenomenon between M-F, in other words, no matter the skin of Ms and man is in anatomical structure or in physiological function, has significant difference.Generally it is presented with following six aspect: (1) Ms's dermal layer of the skin is thin and skin epidermis is thick, and man is then contrary；(2) Ms's skin surface carries bacterial species and quantity are few compared with man；(3) perspiration of Ms and Lactic Acid Secretion are few compared with man, and skin surface pH value is higher；(4) the sebaceous gland body of gland of Ms on average little compared with man, fat secretion is relatively few；(5) pore of Ms is relatively careful；(6) in immunoreation, during the skin wound healing of Ms, inflammatory reaction is more weak than man, and healing time is also relatively short, and therefore women prevalence is far above male.

Therapeutic Method currently for mottle is varied, and curative effect also has very big difference.For the treatment of black speck, it is better than now many with occupational melanosis name.It is cause skin chronic inflammatory disease due to workers with long time exposure Colophonium, coal tar, petroleum-type product or the long-term volatile matter sucking this kind of material, cutaneous pigmentation finally occurs.Therefore in using and producing the process of above-mentioned substance, improve operational approach, reduce touch opportunity as far as possible.Ventilation, aerofluxus, dust collection equipment are installed, reduce flue dust, dust concentration in workshop.During carrying Colophonium, take required safeguard procedures, be preferred with night and cloudy day；Strengthen personal protection, dress working clothing, working cap, mask and glove, the skin of exposure portion is embrocated the protective agent of lucifuge；Dermatitis severe one stops contact, it is to avoid Exposure to Sunlight.Erythra is oozed out, red and swollen substantially person can with 3% boric acid aqueous solution soak, outer wiping zinc oxid oil.General Symptoms severe one can take corticosteroid hormone and antihistamine drug, if desired intravenous drip.Vitamin C has the effect suppressing melanocyte to generate, and can give vitamin C intravenous drip, and multivitamin can be coordinated to treat.Local treatment can external 3% Hydrochinone Cream or 5% ammoniated mercury ointment to pigmentation severe one.The treatment of senile plaque first has to adjust the content of fat in food, eats a little fresh vegetables and fruit more, and informal dress suppresses the medicine of lipid peroxide with some, such as vitamin E and vitamin C, B2, half deamination acid etc..Suitably participate in sports activites, it is to avoid long-time sunlight exposure and abnormal stimulation.Sunscreen cream is adopted for sun-proof.If senile plaque quantity is little, can also be used with the operation such as laser, freezing and remove；Or employing empirical method, every day pats the back of the hand three times, pats rubescent heating, then rubs 100 times, within about two, three months, can die away.Chemistry, the more difficult acceptance of electrical treatment mode, and have certain wound face, the limited efficiency of exercise therapy.

Summary of the invention

For the defect of prior art, the present invention be directed to the present situation for the treatment of at present, it is provided that a kind of pharmaceutical preparation for treating mottle, have no side effect, effective.

Specifically, the concrete scheme of the present invention is achieved in that

First, inventor provides a kind of pharmaceutical preparation for treating mottle according to drug matching experience, and the Chinese medicine ingredients contained in prescription is: Fructus Mori, Folium Nelumbinis, Rhizoma Corydalis Decumbentis, Fructus Alpiniae Oxyphyllae, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.), Medulla Tetrapanacis, Arisaema Cum Bile, Margarita powder, Cortex Phellodendri, Fructus Fici, Herba Potentillae Discoloris, Folium Artemisiae Argyi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Pericarpium Citri grandis, Flos Carthami, Aloe, Semen Abutili, Radix Adenophorae, the Radix Astragali, Fructus Atriplicis Sibiricae.

Further, inventor provides a kind of pharmaceutical preparation for treating mottle according to drug matching experience, each raw material dosage of prescription all has good curative effect in the weight portion scope of the present invention, described formula and weight portion be: Fructus Mori 20-40 part, Folium Nelumbinis 10-16 part, Rhizoma Corydalis Decumbentis 5-11 part, Fructus Alpiniae Oxyphyllae 8-12 part, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 7-14 part, Medulla Tetrapanacis 5-10 part, Arisaema Cum Bile 6-11 part, Margarita powder 10-18 part, Cortex Phellodendri 7-14 part, Fructus Fici 15-25 part, Herba Potentillae Discoloris 4-10 part, Folium Artemisiae Argyi 2-6 part, Radix Glycyrrhizae 6-12 part, Radix Salviae Miltiorrhizae 13-18 part, Pericarpium Citri grandis 9-17 part, Flos Carthami 10-17 part, Aloe 20-40 part, Semen Abutili 6-14 part, Radix Adenophorae 10-19 part, Radix Astragali 15-25 part, Fructus Atriplicis Sibiricae 4-11 part.

Further, the formula of above-mentioned weight portion is carried out preferably, reach superior technique effect, it is preferred that formula is: Fructus Mori 30 parts, 3 parts of Folium Nelumbinis, Rhizoma Corydalis Decumbentis 8 parts, Fructus Alpiniae Oxyphyllae 10 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 10.5 parts, Medulla Tetrapanacis 7.5 parts, Arisaema Cum Bile 8.5 parts, Margarita powder 14 parts, Cortex Phellodendri 11 parts, Fructus Fici 20 parts, Herba Potentillae Discoloris 7 parts, Folium Artemisiae Argyi 4 parts, 10 parts of Radix Glycyrrhizae, Radix Salviae Miltiorrhizae 15 parts, Pericarpium Citri grandis 13 parts, 13.5 parts of Flos Carthami, Aloe 30 parts, Semen Abutili 10 parts, Radix Adenophorae 15 parts, the Radix Astragali 20 parts, Fructus Atriplicis Sibiricae 8 parts.Or: Fructus Mori 32 parts, 3.5 parts of Folium Nelumbinis, Rhizoma Corydalis Decumbentis 10 parts, Fructus Alpiniae Oxyphyllae 11 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 11 parts, Medulla Tetrapanacis 8 parts, Arisaema Cum Bile 9.5 parts, Margarita powder 13 parts, Cortex Phellodendri 11.5 parts, Fructus Fici 21 parts, Herba Potentillae Discoloris 7.5 parts, Folium Artemisiae Argyi 3 parts, 9 parts of Radix Glycyrrhizae, Radix Salviae Miltiorrhizae 16 parts, Pericarpium Citri grandis 14 parts, 14.5 parts of Flos Carthami, Aloe 28 parts, Semen Abutili 9 parts, Radix Adenophorae 15 parts, the Radix Astragali 21 parts, Fructus Atriplicis Sibiricae 8 parts.

In pharmaceutical preparation described above, the Chinese medicine used all uses its conventional medicinal part to be used as medicine, and the dosage of drug used is reasonable, and all medicines have, for treatment skin sore, pox print, mottle, the effect treated preferably after share, especially mottle is treated, it is preferred that treatment chloasma.

The function of each taste Chinese crude drug used in the pharmaceutical preparation of the treatment mottle of the present invention is as follows:

Fructus Mori: sweet in the mouth, cold in nature.

Gui Jing: GUIXIN, liver, kidney channel.

Function cures mainly: YIN nourishing of enriching blood, and promotes the production of body fluid and moisturizes.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.

Folium Nelumbinis: bitter in the mouth, property is put down.

Gui Jing: return liver, spleen, stomach warp.

Function cures mainly: clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis.For summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen, heat in blood tells nosebleed, metrorrhagia of having blood in stool.Burnt FOLIUM NELUMBINIS astringent therapy removing stasis to stop bleeding.For multiple hemorrhage and puerperal blood faints.

Rhizoma Corydalis Decumbentis: bitter in the mouth, warm in nature.

Gui Jing: return Liver Channel.

Function cures mainly: promoting blood circulation to remove obstruction in the collateral, promoting the circulation of QI to relieve pain.For apoplectic hemiplegia, injury from falling down, rheumatic arthritis, sciatica.Fructus Alpiniae Oxyphyllae: acrid in the mouth, warm in nature.

Gui Jing: enter lung, spleen, kidney three warp.

Function cures mainly: mending monarch, Xiang Erhuo and middle burnt gastric qi, by cold-evil, prohibit seminal emission and drown, preventing or arresting vomiting is vomited, and takes the photograph saliva and spittle, adjusts all gas, burnt to pacify three.

Lagotis clarkei Hook. F (Lagotis brevituba Maxim.): bitter in the mouth, cold in nature.

Function cures mainly: heat-clearing and toxic substances removing, blood pressure lowering, regulating menstruation.Main acute, chronic hepatitis；Nephritis；Lung abscess；Hypertension；The moon is often uncomfortable；Breast carcinoma.

Medulla Tetrapanacis: sweet in the mouth, cold in nature.

Gui Jing: attach to the lung and stomach meridians.

Function cures mainly: clearing away heat and promoting diuresis, stimulating milk secretion of ventilating.For hygropyrexia dark coloured urine, the puckery pain of gonorrhea, edema oliguria, agalactia.

Arisaema Cum Bile: bitter in the mouth, cool in nature.

Gui Jing: return lung, liver, spleen channel.

Function cures mainly: removing heat-phlegm, dispelling wind and relieving convulsion.For phlegm-heat cough, cough up phlegm yellow thick, middle wind-phlegm fan, demented infantile convulsion.

Margarita powder: sweet in the mouth, cold in nature.

Gui Jing: GUIXIN, Liver Channel.

Function cures mainly: arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation.For insomnia of palpitating with fear, infantile convulsion epilepsy, the raw nebula of order, skin infection is not held back.

Cortex Phellodendri: bitter in the mouth, cold in nature.

Gui Jing: return kidney, bladder warp.

Function cures mainly: heat clearing and damp drying, and pathogenic fire purging is except steaming, and detoxification sore treatment, sore swollen toxin, eczema pruritus, for hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.

Fructus Fici: property is put down, sweet in the mouth.

Gui Jing: the heart, spleen, stomach.

Function cures mainly: spleen invigorating, nourishes, effect of intestine moistening

Herba Potentillae Discoloris: sweet in the mouth, property is put down.

Function cures mainly: heat-clearing and toxic substances removing；Cooling blood for hemostasis.Main lung-heat cough with asthma；Dysentery；Malaria；Hemoptysis；Have blood in stool；Metrorrhagia；Carbuncle sore tumefacting virus；Skin ulcer tinea tuberculosis.

Folium Artemisiae Argyi: bitter in the mouth, warm in nature.

Gui Jing: return liver,spleen,kidney warp.

Function cures mainly: dispersing cold for relieving pain, warming the meridian for stopping bleeding, vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.

Radix Glycyrrhizae: sweet in the mouth, property is put down.

Gui Jing: enter spleen, stomach, the heart, lung meridian.

Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain.

Radix Salviae Miltiorrhizae: bitter in the mouth, is slightly cold.

Gui Jing: GUIXIN, Liver Channel.

Function cures mainly: blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, and clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle, and for obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, and dysmenorrhea amenorrhea, skin infection swells and ache.

Pericarpium Citri grandis: acrid in the mouth, warm in nature.

Gui Jing: spleen；Kidney；Bladder warp.

Function cures mainly: alleviating distention in middle-JIAO is regulated the flow of vital energy；Help digestion；Reduce phlegm；Relieving cough and asthma.The main stagnation of QI is uncomfortable in chest；Coldness and pain in the epigastrium；Food stagnation；Dysentery；Cough with asthma；Hernia.

Flos Carthami: acrid in the mouth, warm in nature.

Gui Jing: GUIXIN, Liver Channel.

Function cures mainly: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.

Aloe: bitter in the mouth, cold in nature.

Gui Jing: return liver, stomach, large intestine channel.

Function cures mainly: the dizziness of Liver Channel excess-heat, headache, tinnitus, agitation, constipation, pediatric epilepsy scared, infantile malnutrition, catharsis and toxin expelling.

Semen Abutili: bitter in the mouth, property is put down.

Gui Jing: return large intestine, small intestinal, bladder warp.

Function cures mainly: clearing away heat-damp and promoting diuresis, and detoxify nebula removing.For dysentery, the puckery pain of gonorrhea.

Radix Adenophorae: be slightly cold, sweet in the mouth.

Gui Jing: lung, stomach warp.

Function cures mainly: nourishing YIN and clearing away lung-heat, reduces phlegm, QI invigorating.For: lung-heat type cough, deficiency of YIN chronic cough, dry cough expectorant sticks, deficiency of both vital energy and Yin, restlessness and fever with thirst.

The Radix Astragali: sweet in the mouth, warm in nature.

Gui Jing: return lung, spleen channel.

Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and bursts for a long time and does not hold back, and blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst；Chronic nephritis proteinuria, diabetes.

Fructus Atriplicis Sibiricae: acrid in the mouth, warm in nature.

Gui Jing: return Liver Channel.

Function cures mainly: suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, and improving eyesight is antipruritic.For dizziness of having a headache, distending pain in the chest and hypochondrium, breast closes acute mastitis, cataract, rubella pruritus.

Pharmaceutical preparation of the present invention provides a kind of purposes in the pharmaceutical preparation treating skin sore, pox print, mottle, the especially treatment of mottle, it is desirable to for the treatment of chloasma.

A kind of pharmaceutical preparation treating mottle of the present invention, described pharmaceutical preparation application in treatment mottle medicine or cosmetics.

A kind of pharmaceutical preparation treating mottle of the present invention, facial film is prepared in described pharmaceutical preparation.

A kind of pharmaceutical preparation treating mottle of the present invention, external preparation is prepared in described pharmaceutical preparation.It is preferably ointment, ointment.

A kind of pharmaceutical preparation treating mottle of the present invention, granule, powder, capsule, pill, tablet and clinically acceptable dosage form are prepared in described pharmaceutical preparation.It is preferably capsule.

The moulding process that medicine of the present invention prepares different dosage form only used is different with adjuvant, and effective ingredient is the same, and therapeutic effect is also identical or approximate.And preparation first-selection external preparation, the adjuvant of granule can be select in multitudinous Icing Sugar, Carboxymethyl cellulose sodium, dextrin and correctives etc.；Powder can select from starch, kaolin, calcium phosphate, precipitated calcium carbonate etc.；The adjuvant of capsule can select from silicon dioxide, sucrose, HPC, microcrystalline Cellulose, pregelatinized Starch, lactose, Icing Sugar, carboxymethylstach sodium, carmethose, hypromellose etc.；The adjuvant of pill can select from starch, microcrystalline Cellulose, pregelatinized Starch etc.；The adjuvant of tablet can select from starch, dextrin, microcrystalline Cellulose, pregelatinized Starch, magnesium stearate, lactose, Icing Sugar, carboxymethylstach sodium etc..

Pharmaceutical preparation of the present invention can be prepared as facial film, and concrete preparation method is:

(1) take Fructus Mori, Folium Nelumbinis, Rhizoma Corydalis Decumbentis, Fructus Alpiniae Oxyphyllae, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.), Medulla Tetrapanacis, Arisaema Cum Bile, Margarita powder, Cortex Phellodendri, Fructus Fici, Herba Potentillae Discoloris, Folium Artemisiae Argyi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Pericarpium Citri grandis, Flos Carthami, Aloe, Semen Abutili, Radix Adenophorae, the Radix Astragali and the Fructus Atriplicis Sibiricae that take weight ratio grind to form smalls, cross 120 mesh sieves, standby；

(2) after the fine powder of step (1) being carried out aseptic dried standby；

(3) Chinese medicinal powder Ovum Gallus domesticus album or sterilized water furnishing pasty state are freckle-removing mask.

Pharmaceutical preparation of the present invention can be prepared as ointment, and concrete preparation method is as follows:

(1) corresponding raw material components is weighed according to weight standby；

(2) by Lagotis clarkei Hook. F (Lagotis brevituba Maxim.), Herba Potentillae Discoloris, Radix Glycyrrhizae, turn over Medulla Tetrapanacis, Arisaema Cum Bile becomes fine powder, cross 80-100 order shine, standby；

(3) Rhizoma Corydalis Decumbentis, Fructus Alpiniae Oxyphyllae, Margarita powder, Folium Artemisiae Argyi, Cortex Phellodendri, Radix Salviae Miltiorrhizae, Flos Carthami, Semen Abutili, Radix Adenophorae, the Radix Astragali and Fructus Atriplicis Sibiricae are adopted alcohol extracting method, grinding obtains coarse powder, 65-75% ethanol backwash 1-3 time, each 1-3 hour, medicinal liquid filters, reclaims ethanol, 60-80 DEG C, it is evaporated to the extractum that relative density is 1.02-1.05, standby；

(4) Fructus Mori, Folium Nelumbinis, Fructus Fici, Pericarpium Citri grandis and Aloe are added the pure water of 6-12 times of volume, decocts secondary, 1-1.5 hour first time, second time 0.5-1 hour, collecting decoction, filter, be evaporated to the extractum that relative density is 1.05-1.10, standby；

(5) extractum in step (3) and step (4) is taken, freezing, to pulverize, combination drying obtains mixture, standby.

(6) measuring glyceryl monostearate, stearic acid, white vaseline, triethanolamine heating in water bath to fusing by prescription, mixing, as oil phase.Additionally take appropriate purified water, the mixture of step (5) is dissolved in water.

(7) take glycerol, sodium lauryl sulphate, purified water, ethyl hydroxybenzoate are mixed and heated to about 80 DEG C, as aqueous phase.When oil phase temperature is about 80 DEG C, under stirring, the solution of step (6) is added wherein, and keep the temperature at about 80 DEG C, by the oil phase after stirring, under low rate mixing, it is slowly added in aqueous phase, the rear stirring 30min that accelerates, stopping stirring, obtain emulsifiable paste.

Pharmaceutical preparation of the present invention can be prepared as capsule, and concrete preparation method is:

(5) extractum in step (3) and step (4) is taken, freezing, to pulverize, combination drying obtains mixture, loads capsule, capsule weight 150mg.

Compared with prior art, the present invention treats the pharmaceutical preparation of mottle and has the advantage that

(1) according to theory of Chinese medical science, the pharmaceutical preparation of the present invention can suppress the activity of tryrosinase, promotes that melanin decomposes, improves microcirculation.Suppress the harmful microbe such as antibacterial, fungus to increase, also can improve skin to ultraviolet sensitivity, have the effect of good longue skin, profit color.

(2) all medicines share, and reach blood-activating and qi-promoting, the effect of blood-nourishing and freckle-removing, treating both the principal and secondary aspects of a disease, and recurrence rate after healing is low, and easy to use, have no side effect, easy to utilize.

Specific embodiment

It is obvious to a person skilled in the art that the details of the embodiment of the present invention, and when without departing substantially from the spirit of the present invention or basic feature, it is possible to realize the present invention in other specific forms.Embodiment all should be regarded as exemplary, and be nonrestrictive, it is intended that all changes in the implication of the equivalency dropping on claim and scope are included in the present invention.

Embodiment 1: a kind of capsule for treating mottle, containing the Chinese crude drug of following weight portion:

Fructus Mori 30 grams, 3 grams of Folium Nelumbinis, Rhizoma Corydalis Decumbentis 8 grams, Fructus Alpiniae Oxyphyllae 10 grams, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 10.5 grams, Medulla Tetrapanacis 7.5 grams, Arisaema Cum Bile 8.5 grams, Margarita powder 14 grams, Cortex Phellodendri 11 grams, Fructus Fici 20 grams, Herba Potentillae Discoloris 7 grams, Folium Artemisiae Argyi 4 grams, 10 grams of Radix Glycyrrhizae, Radix Salviae Miltiorrhizae 15 grams, Pericarpium Citri grandis 13 grams, 13.5 grams of Flos Carthami, Aloe 30 grams, Semen Abutili 10 grams, Radix Adenophorae 15 grams, the Radix Astragali 20 grams, Fructus Atriplicis Sibiricae 8 grams.

Concrete preparation method is:

Embodiment 2: a kind of ointment for treating mottle, containing the Chinese crude drug of following weight portion:

Concrete preparation method is:

Embodiment 3: a kind of facial film for treating mottle, containing the Chinese crude drug of following weight portion:

Concrete preparation method is:

Embodiment 4: a kind of ointment for treating mottle, containing the Chinese crude drug of following weight portion:

Concrete preparation method is:

(2) by Lagotis clarkei Hook. F (Lagotis brevituba Maxim.), Herba Potentillae Discoloris, Radix Glycyrrhizae, turn over Medulla Tetrapanacis, Arisaema Cum Bile, one-tenth fine powder, cross 80-100 order and shine, standby；

Embodiment 5: a kind of capsule for treating mottle, containing the Chinese crude drug of following weight portion:

Fructus Mori 40 grams, 16 grams of Folium Nelumbinis, Rhizoma Corydalis Decumbentis 11 grams, Fructus Alpiniae Oxyphyllae 12 grams, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 14 grams, Medulla Tetrapanacis 10 grams, Arisaema Cum Bile 11 grams, Margarita powder 18 grams, Cortex Phellodendri 14 grams, Fructus Fici 25 grams, Herba Potentillae Discoloris 10 grams, Folium Artemisiae Argyi 6 grams, 12 grams of Radix Glycyrrhizae, Radix Salviae Miltiorrhizae 18 grams, Pericarpium Citri grandis 17 grams, 17 grams of Flos Carthami, Aloe 40 grams, Semen Abutili 14 grams, Radix Adenophorae 19 grams, the Radix Astragali 25 grams, Fructus Atriplicis Sibiricae 11 grams.

Concrete preparation is with embodiment 1.

Embodiment 6: a kind of capsule for treating mottle, containing the Chinese crude drug of following weight portion:

Fructus Mori 20 grams, 10 grams of Folium Nelumbinis, Rhizoma Corydalis Decumbentis 5 grams, Fructus Alpiniae Oxyphyllae 8 grams, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 7 grams, Medulla Tetrapanacis 5 grams, Arisaema Cum Bile 6 grams, Margarita powder 10 grams, Cortex Phellodendri 7 grams, Fructus Fici 15 grams, Herba Potentillae Discoloris 4 grams, Folium Artemisiae Argyi 2 grams, 6 grams of Radix Glycyrrhizae, Radix Salviae Miltiorrhizae 13 grams, Pericarpium Citri grandis 9 grams, 10 grams of Flos Carthami, Aloe 20 grams, Semen Abutili 6 grams, Radix Adenophorae 10 grams, the Radix Astragali 15 grams, Fructus Atriplicis Sibiricae 4 grams.

Concrete preparation is with embodiment 1.

Embodiment 7: a kind of capsule for treating mottle, containing the Chinese crude drug of following weight portion:

Fructus Mori 32 grams, 3.5 grams of Folium Nelumbinis, Rhizoma Corydalis Decumbentis 10 grams, Fructus Alpiniae Oxyphyllae 11 grams, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 11 grams, Medulla Tetrapanacis 8 grams, Arisaema Cum Bile 9.5 grams, Margarita powder 13 grams, Cortex Phellodendri 11.5 grams, Fructus Fici 21 grams, Herba Potentillae Discoloris 7.5 grams, Folium Artemisiae Argyi 3 grams, 9 grams of Radix Glycyrrhizae, Radix Salviae Miltiorrhizae 16 grams, Pericarpium Citri grandis 14 grams, 14.5 grams of Flos Carthami, Aloe 28 grams, Semen Abutili 9 grams, Radix Adenophorae 15 grams, the Radix Astragali 21 grams, Fructus Atriplicis Sibiricae 8 grams.

Concrete preparation is with embodiment 1.

Embodiment 8: a kind of ointment for treating mottle, containing the Chinese crude drug of following weight portion:

Concrete preparation is with embodiment 2.

Embodiment 9: a kind of ointment for treating mottle, containing the Chinese crude drug of following weight portion:

Concrete preparation is with embodiment 3.

Embodiment 10: animal model test

10.1, animal modeling

Taking 80 Cavia porcellus adaptabilities to raise 1 week, labelling, lost hair or feathers to each guinea pig back after one week respectively.First will become mildewed with curved scissors and cut short, and then use house pet Special electric clipper to shave shorter by guinea pig back hair, in order to hair can be fully contacted depilation solution, reaches the purpose lost hair or feathers completely.Utilize different ultraviolet B radiation that guinea pig skin pigmentation and alpha-melanophore are stimulated the impact expressed, Cavia porcellus eye face shield is hidden, is contained in uncovered cage, fully expose back baring skin, being positioned over phototherapy unit central authorities after pacifying, initial illumination dose is 200mj/cm², each dosage increases by 20%, occurs that erythema then increases by 10%, occurs that clear erythema suspends 1 treatment, vesicle, pain etc. occurs, and illumination suspends to remission.Irradiating 3 times weekly, concurrent irradiation 8 weeks, guinea pig back skin forms stable and uniform pigmentation.

10.2, packet and administration

Successful for modeling rabbit is randomly divided into 7 groups, often group 10, respectively model group, positive controls, Chinese medicine external group, oral medicinal herb group, oral medicinal herb+external low dose group (A group), dosage group (B group) in oral medicinal herb+external, oral medicinal herb+external high dose group (C group), 4 courses for the treatment of Monday, the Therapeutic Method often organized is in Table 1:

Table 1 respectively organizes dosage and mode is as follows

Group	Quantity	Administration kind	Dosage (mg.kg^-1)
				Normal group	10	Normal saline	2
Model group	10	Normal saline	2
				Positive controls	10	Outer painting hydroquinone ointment	Every day 2 times
Oral medicinal herb group	10	Embodiment 1	60
				Chinese medicine external group	10	Embodiment 2	Every day 2 times
A group	10	Embodiment 1+ embodiment 2	30+ every day 2 times
				B group	10	Embodiment 1+ embodiment 2	60+ every day 2 times
C group	10	Embodiment 1+ embodiment 2	90++ every day 2 times

10.3, index observing

10.3.1 untoward reaction is observed

In the beginning of experiment, after modeling, and Cavia porcellus is shot by medication for 2 weeks, 4 weeks and 6 weeks respectively, observes and records guinea pig back baring skin pigment, erythema and desquamation situation, and complete experimental record in time.

Curative effect naked eyes criterion

According to it from shallow to being deeply divided into: normal skin tone (0 point), filbert (1 point), brown (2 points), dark brown (3 points), black (4 points).

Observe erythema situation record, be divided into: 0 point (without erythema), 1 point (slight erythema), 2 points (moderate erythema), 3 points (erythema companion detumescence, crust, necrosis).

Observe squama situation record, be divided into: 0 point (without squama), 1 point (a small amount of squama), 2 points (moderate squama), 3 points (notable squama).

If pigmentation, erythema, squama situation are between different mark levels, then take both averages.

Untoward reaction total mark=erythema total mark+squama total mark.

10.3.2 light Microscopic observation melanin situation

After experiment terminates, put to death animal, take Cavia porcellus each district skin histology, carry out labelling and make pathological section, carry out conventional H E dyeing and Masson-Fontana dyeing.Melanin granule and argentaffin are black, and collagen fiber etc. take on a red color.It is placed under microscope by the pathology sheet being fabricated to read tablet and photographs.The section mesocuticle cell arrangement structure change of skin histopathology of optical microphotograph Microscopic observation HE dyeing each district, epidermal thickness and collagen fiber hyperplasia, lymphocytic infiltration situation etc..Melanin granule to Masson-Fontana dyeing display, takes 5 visuals field under high power lens, contained melanin granule number in every 200 keratinocytes of count table cortex,

10.4, experimental result

10.4.1 the untoward reaction situation that perusal is to skin

Root blank group is compared, the each group of untoward reaction all having skin in various degree, wherein the untoward reaction of positive controls is maximum, and model group is minimum, oral medicinal herb or external all have untoward reaction in various degree, the untoward reaction of group for oral administration is minimum, positive controls and each group of Chinese medicine all statistically significant compared with model group (see table 2).

Skin adverse reaction situation in guinea-pig studies intervention is respectively organized in table 2. perusal

Note: compare with positive controls, #p < 0.05, ##p < 0.01

Root model group is compared, and the melanin number of each treatment group all has each group of reduction, positive controls and Chinese medicine all statistically significant compared with model group (see table 3).

Table 3 guinea pig back each district the black pigment of skin granule reduces the comparison of number

Group	Skin number (block)	Melanin granule number (individual)
			Blank group	2	8.37±2.07
Model group	10	20.36±2.77
			Positive controls	10	14.60±2.35#
Chinese medicine external group	10	12.74±1.90##
			Oral medicinal herb group	10	13.38±2.39#
A group	10	11.38±2.15##
			B group	10	9.37±3.21##
C group	10	8.39±1.25##

Note:

Compare with model group, #p < 0.05, ##p < 0.01；

With positive controls, p < 0.05, p < 0.01.

From table 3 it can be seen that model group melanin granule number has significant difference (p < 0.05 or p < 0.01) with positive controls, Chinese medicine external group, oral medicinal herb group A group, B group and C group.Wherein, B group has significant difference (p < 0.05) with C group compared with positive controls.

Embodiment 12: clinical trial

12.1, physical data

Accept for medical treatment because of the medical 320 example patients of mottle during my institute's department of dermatologry of 2012-2014, wherein treatment group I group 80 example, treatment group II group 80 example, treatment group III group 80 example, observation group 80 example, 15～46 years old age, average 28 years old；The course of disease 2 months～13 years, average 4.5 years.At sex, age, Clinical typing between treatment group and with matched group, through statistical procedures, P > 0.05, there is comparability.

12.2, therapeutic scheme

Treatment group I group: 80 examples, male 60 examples, female 20 example, the capsule of embodiment 1, one time three times, one time 2,15 days courses for the treatment of.

Treatment group II group: 80 examples, male 60 examples, female 20 example, the ointment of embodiment 2, smear affected part, one day 2 times, sooner or later respectively once, 15 days courses for the treatment of.

Treatment group III group: 80 examples, male 60 examples, female 20 example, the capsule of embodiment 1, one time three times, one time 2, then add the ointment of embodiment 2, smear affected part, one day 2 times, 15 days courses for the treatment of.

Observation group: 80 examples, male 60 examples, female 20 example, stonecrop spot removal tablet is administered orally, a 3-4 sheet, 2 times on the one, 15 days courses for the treatment of.

12.3, criterion of therapeutical effect

Recovery from illness: skin lesion all or substantially disappears, color is normal or close normal.

Effective: skin lesion is obviously reduced, color substantially shoals.

Effective: skin lesion reduces, lighter.

Obvious effective rate: (cure+effective)/diseased individuals.

Invalid: skin lesion is without obvious change, and color is slightly light.

Repeatedly: the individuality of recovery from illness+effective recurrence.

12.4, therapeutic outcome

Result is in Table 4, and through statistical analysis, two groups compare, and the obvious effective rate for the treatment of group is higher than matched group (table 4), has significant difference (P < 0.05).

The therapeutic outcome of table 4 observation group and treatment group

Group	Cure	Effective	Effectively	Invalid	Obvious effective rate (%)	Repeatedly
							Observation group	18	22	25	15	50	12
Treatment group I group	35	28	14	3	96.3	2
							Treatment group II group	40	30	8	2	97.5	3
Treatment group III group	45	31	3	1	98.8	0

As can be seen from Table 4, observation group: cure 18 examples, effective 22 examples, effective 25 examples, invalid 15 examples, obvious effective rate 50%, repeatedly 12 example；Treatment group I group: cure 35 examples, effective 28 examples, effective 14 examples, invalid 3 examples, obvious effective rate 96.3%, repeatedly 2 example；Treatment group II group cures 40 examples, effective 30 examples, effective 8 examples, invalid 2 examples, obvious effective rate 97.5%, repeatedly 3 example；Treatment group III group cures 45 examples, effective 31 examples, effective 3 examples, invalid 1 example, obvious effective rate 98.8%, repeatedly 0 example.Treatment group and observation group's person's statistical procedures, P < 0.05, have significant difference.

12.5, model case

Case 1: shut out certain, female, 33 years old, Yunnan Jian Shui people, guide, patient's private prosecution was in the impact of Yunnan head ultraviolet radiation.Facial colour spot exists always, nearly 3 years, after adding fertility two tires, mottle is serious especially, especially serious at the mottle of eyebrow, bridge of the nose place, uses multiple whitening product and facial film, poor effect and recurrent exerbation, coming my institute to check, doctor advised uses the ointment of embodiment 2, further consultation after treating 1 month, mottle desalination is a lot, being continuing with above method 1 month, mottle disappears substantially, follows up a case by regular visits to not recurrence in 6 months.

Case 2: bent certain, man, 29 years old, people from Dali, courier, patient hurries back and forth in outdoor from the cause and does not have sun-proof measure every day, operating pressure is big, in family, trival matters are many, and the change of job specification, often go out and cause that mottle increases the weight of, outside mottle at eye is especially apparent, without the problem of other skin aspects, doctor advised uses the capsule of embodiment 1 and the ointment of embodiment 2, further consultation after treating 1 month, mottle desalination is a lot, being continuing with above method 1 month, mottle disappears substantially, follows up a case by regular visits to not recurrence in 6 months.

Claims

1. the pharmaceutical preparation being used for treating mottle, it is characterized in that, described pharmaceutical preparation includes following Chinese crude drug: Fructus Mori, Folium Nelumbinis, Rhizoma Corydalis Decumbentis, Fructus Alpiniae Oxyphyllae, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.), Medulla Tetrapanacis, Arisaema Cum Bile, Margarita powder, Cortex Phellodendri, Fructus Fici, Herba Potentillae Discoloris, Folium Artemisiae Argyi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Pericarpium Citri grandis, Flos Carthami, Aloe, Semen Abutili, Radix Adenophorae, the Radix Astragali, Fructus Atriplicis Sibiricae.

2. pharmaceutical preparation according to claim 1, it is characterized in that, described pharmaceutical preparation includes following weight portion Chinese crude drug: Fructus Mori 20-40 part, Folium Nelumbinis 10-16 part, Rhizoma Corydalis Decumbentis 5-11 part, Fructus Alpiniae Oxyphyllae 8-12 part, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 7-14 part, Medulla Tetrapanacis 5-10 part, Arisaema Cum Bile 6-11 part, Margarita powder 10-18 part, Cortex Phellodendri 7-14 part, Fructus Fici 15-25 part, Herba Potentillae Discoloris 4-10 part, Folium Artemisiae Argyi 2-6 part, Radix Glycyrrhizae 6-12 part, Radix Salviae Miltiorrhizae 13-18 part, Pericarpium Citri grandis 9-17 part, Flos Carthami 10-17 part, Aloe 20-40 part, Semen Abutili 6-14 part, Radix Adenophorae 10-19 part, Radix Astragali 15-25 part, Fructus Atriplicis Sibiricae 4-11 part.

3. pharmaceutical preparation according to claim 1, it is characterized in that, described pharmaceutical preparation includes following weight portion Chinese crude drug: Fructus Mori 30 parts, 3 parts of Folium Nelumbinis, Rhizoma Corydalis Decumbentis 8 parts, Fructus Alpiniae Oxyphyllae 10 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 10.5 parts, Medulla Tetrapanacis 7.5 parts, Arisaema Cum Bile 8.5 parts, Margarita powder 14 parts, Cortex Phellodendri 11 parts, Fructus Fici 20 parts, Herba Potentillae Discoloris 7 parts, Folium Artemisiae Argyi 4 parts, 10 parts of Radix Glycyrrhizae, Radix Salviae Miltiorrhizae 15 parts, Pericarpium Citri grandis 13 parts, 13.5 parts of Flos Carthami, Aloe 30 parts, Semen Abutili 10 parts, Radix Adenophorae 15 parts, the Radix Astragali 20 parts, Fructus Atriplicis Sibiricae 8 parts.

4. pharmaceutical preparation according to claim 1, it is characterized in that, described pharmaceutical preparation includes following weight portion Chinese crude drug: Fructus Mori 32 parts, 3.5 parts of Folium Nelumbinis, Rhizoma Corydalis Decumbentis 10 parts, Fructus Alpiniae Oxyphyllae 11 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 11 parts, Medulla Tetrapanacis 8 parts, Arisaema Cum Bile 9.5 parts, Margarita powder 13 parts, Cortex Phellodendri 11.5 parts, Fructus Fici 21 parts, Herba Potentillae Discoloris 7.5 parts, Folium Artemisiae Argyi 3 parts, 9 parts of Radix Glycyrrhizae, Radix Salviae Miltiorrhizae 16 parts, Pericarpium Citri grandis 14 parts, 14.5 parts of Flos Carthami, Aloe 28 parts, Semen Abutili 9 parts, Radix Adenophorae 15 parts, the Radix Astragali 21 parts, Fructus Atriplicis Sibiricae 8 parts.

5. pharmaceutical preparation according to claim 1, it is characterized in that: described pharmaceutical dosage form one in granule, capsule, tablet, injection, tincture, suppository, pill, syrup, mixture, powder, lotion, membrane, drop pill, more preferably capsule.

6. pharmaceutical preparation according to claim 1, it is characterised in that described pharmaceutical preparation application in preparation treatment mottle medicine or cosmetics.

7. pharmaceutical preparation according to claim 1, it is characterised in that facial film is prepared in described pharmaceutical preparation.

8. the pharmaceutical preparation according to claim 1, it is characterised in that external preparation is prepared in described pharmaceutical preparation, it is preferred that the one in ointment, ointment.

9. pharmaceutical preparation according to claim 1, it is characterised in that described pharmaceutical preparation is in the purposes in preparation treatment mottle medicine.

10. pharmaceutical preparation according to claim 1, it is characterised in that described pharmaceutical preparation is in the purposes in preparation treatment chloasma medicine.