CN103028093B - Traditional Chinese medicine composition for treating chronic obstructive pulmonary emphysema and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for treating chronic obstructive pulmonary emphysema and preparation method of traditional Chinese medicine composition Download PDF

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CN103028093B
CN103028093B CN201210594482.9A CN201210594482A CN103028093B CN 103028093 B CN103028093 B CN 103028093B CN 201210594482 A CN201210594482 A CN 201210594482A CN 103028093 B CN103028093 B CN 103028093B
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weight
volatile oil
rhizoma
filtration
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CN103028093A (en
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董晓红
姚壮
王磊
孙琪
李文秀
李硕熙
高莹
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Dong Xiaohong
Yao Zhuang
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Abstract

The invention provides a traditional Chinese medicine composition for treating chronic obstructive pulmonary emphysema. The traditional Chinese medicine composition comprises gecko, semen coicis, radix pseudostellariae, liquorice, rhizoma polygonati, schisandra chinensis, fenugreek, caulis spatholobi, turmeric, seabuckthorn, aleppo avens, cynanchum glaucescens, fructus forsythiae, herba inulae, herba ephedra, myristica fragrans, cordyceps sinensis, fructus aristolochiae, semen euryales, kelp, radix curcumae, pericarpium citri reticulatae, resina liquidamberis, rhizoma alpiniae officinarum, agilawood, rhizoma anemarrhenae, polygonum cuspidatum and caulis sargentodoxae. The traditional Chinese medicine composition can regulate lung functions of a patient, improve inherent antiviral ability, treat both symptoms and root causes, can control the illness fundamentally, defer the progression of the illness and treat the illness, and has the advantages that the traditional Chinese medicine composition is good in curative effect, takes effect rapidly, causes no injuries to a human body, does not result in tolerance, has no toxic or side effects, and the illness is not recurrent compared with western medicine.

Description

For treating Chinese medicine composition of chronic obstructive emphysema and preparation method thereof
Technical field
The present invention relates to Chinese medicine technical field, more particularly, to a kind of Chinese medicine group for treating chronic obstructive emphysema Compound and preparation method thereof.
Background technology
Chronic obstructive emphysema is a kind of chronic respiratory system diseasess being characterized with not fully reversible flow limitation, Refer to the air flue elasticity attenuation of terminal bronchiole far-end (alveolar bronchiole, alveolar duct, alveolar sac and alveolar), excessively swollen The pathological state that swollen, inflation and Pulmonary volume increase or destroy with airway walls simultaneously, because its morbidity is slow, the course of disease is longer, therefore Referred to as chronic obstructive emphysema, the sickness rate in the northern area of China and case fatality rate are all higher, and this sick sickness rate with The change of society and nature's environment, humanistic environment etc., have the trend raising year by year.
Chronic obstructive emphysema is not a single disease, is merely only to come from the angle of an anatomical term See, emphysema are old-slow-bronchial tube or other chronic respiratory system diseasess develop into a certain degree of, ultimately form not fully reversible Flow limitation result, the morbidity of this disease is slow, the course of disease is longer, if treatment is not in time, protracted inflammation is possible to induce pulmonary Canceration, finally jeopardizes patient vitals, and therefore this disease of effectively treatment is significant early in time.
Chronic obstructive emphysema is multifactor formation, including infection, smoking, atmospheric pollution, occupational dusts, is harmful to Gas sucks for a long time, allergy etc., its pathogenesis include bronchitiies so that tube chamber is blocked, inflammatory destruction bronchia wall soft Bone, leukocyte and macrophage release protease infringement lung tissue and the pressurized blood supply of alveolar wall blood capillary reduce.Alveolar wall hair Thin blood vessel constriction, lung tissue blood supply reduces cause malnutrition and makes alveolar wall elasticity attenuation, Elastic protease and its inhibitor Unbalance.There is elastoser and elastase inhibitor (predominantly α in human body1- antitrypsin), during smoking can make Property granulocyte release elastoser, the peroxide in smog can make α1- antitryptic activity reduces, and leads to lung tissue Elastic fiberss decompose, and cause emphysema.Additionally, congenital hereditary lacks α1- antitrypsin person easily sends out emphysema.Patient removes and coughs Cough, cough up phlegm etc. outside chronic bronchitis shape, often occur because of obstructive ventilatory disorder expiratory dyspnea, tachypnea, uncomfortable in chest, The hypoxic conditions such as cyanosis.Severe patient makes lift on rib because being chronically at excessive suction condition, and intercostal space is broadening, and thorax anteroposterior diameter adds Greatly, form the distinctive sign of emphysema patient " barrel chest ".Chronic inflammatory disease destroys bronchia cartilago parietalis, loses its support and makees With when causing to exhale, bronchus excessively reduce or fall into and close, and lead to residual volume in alveolar to increase.Recurrent pulmonary infection and chronic inflammatory disease make The protease of leukocyte and macrophage release increases, and damages lung tissue and alveolar wall, leads to multiple fusion of pulmonary alveoli to become lung Bulla.
At present clinically doctor trained in Western medicine this disease is relievingd asthma frequently with spasmolytic, antiinflammatory, the conventional Comprehensive Treatment such as hormone and oxygen uptake, but The target of its treatment primary disease mainly delays emophysematous development, plays the compensatory capacity of body, improves respiratory function, improves life Life quality, prevents heart failure and respiratory failure.Emphysema patient often has recurrent respiratory tract infection medical history, and each subinfection is led The increasing further of pathogenic feelings, pulmonary function goes down further.Once being formed, the destruction of lung tissue is irreversible being difficult to emphysema Repair, therefore western medical treatment is extremely limited, and there are certain toxic and side effects, and clinical effectiveness is unsatisfactory.
Differentiation of tcm and organic conception are directed to the lifting of the body entirety resistance of patient, using Chinese medicine Adjust patient lungs' function, transfer in body in resistances against diseases, be to take stopgap measures and effect a permanent cure.With respect to western medicine chronic obstructive Emphysema, using Chinese traditional treatment can fundamentally symptom management, delay the progress of the state of an illness, realize treatment, and toxic and side effects Little, have no drug resistance, therefore evident in efficacy.
The present invention is exactly in this context, theoretical according to Chinese traditional treatment, proposes one kind and is used for treating chronic obstructive lung qi Swollen Chinese medicine composition, it passes through to adjust the lung functions of patient, the inherent anti-virus ability of raising, and treating both the principal and secondary aspects of a disease can be from root Symptom management in basis, delays the progress of the state of an illness, and realizes treating, and with respect to Western medicine, it has good effect, and instant effect, to people Body not damaged, the state of an illness not repeatedly, has no drug resistance and toxic and side effects.
Content of the invention
The technical problem to be solved is, provides a kind of Chinese medicine group for treating chronic obstructive emphysema Compound, it passes through to adjust the lung functions of patient, improves inherent anti-virus ability, treating both the principal and secondary aspects of a disease, can fundamentally control disease Feelings, delay the progress of the state of an illness, and realize treating, and with respect to Western medicine, it has good effect, and instant effect, to human zero damage, disease Feelings not repeatedly, have no drug resistance and toxic and side effects.
In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine group for treating chronic obstructive emphysema Compound, its crude drug includes：Gecko, Semen Coiciss, Radix Pseudostellariae, Radix Glycyrrhizae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Semen Trigonellae, Caulis Spatholobi, Rhizoma Curcumae Longae, sand Spine, Radix seu Herba Gei aleppici, Rhizoma Cynanchi Stauntonii, Fructus Forsythiae, Herba Inulae, Herba Ephedrae, Semen Myristicae, Cordyceps, Fructus Aristolochiae, Semen Euryaless, Thallus Laminariae (Thallus Eckloniae), Radix Curcumae, Pericarpium Citri Reticulatae, maple Face cream, Rhizoma Alpiniae Officinarum, Lignum Aquilariae Resinatum, the Rhizoma Anemarrhenae, Rhizoma Polygoni Cuspidati, Caulis Sargentodoxae.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Gecko 60 weight portion ~ 70 weight portion, Semen Coiciss Core 40 weight portion ~ 50 weight portion, Radix Pseudostellariae 100 weight portion ~ 110 weight portion, Radix Glycyrrhizae 35 weight portion ~ 45 weight portion, Rhizoma Polygonati 70 weight Amount part ~ 80 weight portion, Fructus Schisandrae Chinensis 50 weight portion ~ 60 weight portion, Semen Trigonellae 25 weight portion ~ 35 weight portion, Caulis Spatholobi 45 weight portion ~ 55 weight portions, Rhizoma Curcumae Longae 30 weight portion ~ 40 weight portion, Fructus Hippophae 35 weight portion ~ 45 weight portion, Radix seu Herba Gei aleppici 45 weight portion ~ 55 weight portion, Rhizoma Cynanchi Stauntonii 25 weight portion ~ 35 weight portion, Fructus Forsythiae 35 weight portion ~ 45 weight portion, Herba Inulae 40 weight portion ~ 50 weight portion, Herba Ephedrae 40 weight Amount part ~ 50 weight portion, Semen Myristicae 25 weight portion ~ 35 weight portion, Cordyceps 20 weight portion ~ 30 weight portion, Fructus Aristolochiae 30 weight Part ~ 40 weight portions, Semen Euryaless 30 weight portion ~ 40 weight portion, Thallus Laminariae (Thallus Eckloniae) 20 weight portion ~ 30 weight portion, Radix Curcumae 15 weight portion ~ 25 weight Part, Pericarpium Citri Reticulatae 30 weight portion ~ 40 weight portion, Resina Liquidambarises 25 weight portion ~ 35 weight portion, Rhizoma Alpiniae Officinarum 20 weight portion ~ 30 weight portion, Lignum Aquilariae Resinatum 20 weight portion ~ 30 weight portions, the Rhizoma Anemarrhenae 55 weight portion ~ 65 weight portion, Rhizoma Polygoni Cuspidati 75 weight portion ~ 85 weight portion, Caulis Sargentodoxae 30 weight portion ~ 40 weight portions.
Wherein, the dosage form of described Chinese medicine composition is tablet, soft capsule, powder, granule, pill, mixture.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is granule Agent, it is specially：
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixing Thing, is subsequently added the distillation water retting 2h ~ 4h with respect to 6 ~ 8 times of mixture quality, pours in volatile oil extractor, the way of distillation carries Take volatile oil 4 ~ 6h, obtain volatile oil extracting solution, remaining Aqueous extracts filter, add in residue with respect to 4 ~ 6 times of its quality The ethanol of determining alcohol 70% ~ 80%, heating and refluxing extraction 2 ~ 3 times, extract 2 ~ 4h every time, extracting solution merges, filters, and previously obtained Filtration after Aqueous extracts merge, obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distillation of these component raw material medicine gross weight meter 5 ~ 7 times amount Water, decocts 2 ~ 4 hours, and filtration adds the distilled water of these component raw material medicine gross weight meter 5 ~ 7 times amount in medicinal residues, decocts 1 ~ 3 Hour, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05 ~ 0.1Mpa, vacuum be -0.02 ~ - Under conditions of 0.1Mpa, being concentrated into relative density at 60 DEG C is 1.1 ~ 1.3 clear paste, lets cool, and it is 70% ~ 80% that side adds determining alcohol Ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50% ~ 60% (V/V), stands overnight, filtration, filtering residue adds phase Determining alcohol for 2 ~ 4 times of its quality is 70% ~ 80% ethanol, is sufficiently stirred for, and filtration merges filtrate twice, and previously obtained First filtrate mixing, concentrating under reduced pressure removes solvent, obtains dry cream, is ground into powder, obtains dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality, being slowly added to The volatile oil of one step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4~1:5, and it is stirred continuously 1h ~ 2h, after cold preservation 24h, Filter, be spray-dried, pulverize, obtain volatile oil embedded object；
4th step, dried cream powder and the mixing of volatile oil embedded object are subsequently added dextrin and sucrose, with respect to 100 weight portions Dried cream powder, the addition of dextrin is 100 weight portion ~ 150 weight portions, and the addition of sucrose is 250 weight portion ~ 350 weight portions, It is placed in wet granulator, mixes 3 ~ 8 minutes, make granule, send in vacuum drier and be vacuum dried, temperature of charge is 40 ~ 70 DEG C, vacuum is -0.08Mpa ~ -0.12Mpa, and charging rate is 15 ~ 20L/h, and material strip transfer rate is 20 ~ 30cm/ Min, subpackage after being dried.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, It is specially：
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixing Thing, is subsequently added the distillation water retting 2h ~ 4h with respect to 6 ~ 8 times of mixture quality, pours in volatile oil extractor, the way of distillation carries Take volatile oil 4 ~ 6h, obtain volatile oil extracting solution, remaining Aqueous extracts filter, add in residue with respect to 4 ~ 6 times of its quality The ethanol of determining alcohol 70% ~ 80%, heating and refluxing extraction 2 ~ 3 times, extract 2 ~ 4h every time, extracting solution merges, filters, and previously obtained Filtration after Aqueous extracts merge, obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distillation of these component raw material medicine gross weight meter 5 ~ 7 times amount Water, decocts 2 ~ 4 hours, and filtration adds the distilled water of these component raw material medicine gross weight meter 5 ~ 7 times amount in medicinal residues, decocts 1 ~ 3 Hour, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05 ~ 0.1Mpa, vacuum be -0.02 ~ - Under conditions of 0.1Mpa, being concentrated into relative density at 60 DEG C is 1.1 ~ 1.3 clear paste, lets cool, and it is 70% ~ 80% that side adds determining alcohol Ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50% ~ 60% (V/V), stands overnight, filtration, filtering residue adds phase Determining alcohol for 2 ~ 4 times of its quality is 70% ~ 80% ethanol, is sufficiently stirred for, and filtration merges filtrate twice, and previously obtained First filtrate mixing, concentrating under reduced pressure removes solvent, obtains dry cream, be ground into dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality, being slowly added to The volatile oil of one step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4~1:5, and it is stirred continuously 1h ~ 2h, after cold preservation 24h, Filter, be spray-dried, pulverize, obtain volatile oil embedded object；
The volatile oil embedded object mixing that 4th step, the dried cream powder that obtain second step and the 3rd step obtain, sends into vacuum and does Be vacuum dried in dry machine, temperature of charge be 40 ~ 70 DEG C, vacuum be -0.08Mpa ~ -0.12Mpa, charging rate be 15 ~ 20L/h, material strip transfer rate is 20 ~ 30cm/min, sends into the powder being ground into 100 mesh ~ 200 mesh in pulverizer, and ultraviolet kills Poison, obtains powder.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is capsule Agent, it is specially：
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixing Thing, is subsequently added the distillation water retting 2h ~ 4h with respect to 6 ~ 8 times of mixture quality, pours in volatile oil extractor, the way of distillation carries Take volatile oil 4 ~ 6h, obtain volatile oil extracting solution, remaining Aqueous extracts filter, add in residue with respect to 4 ~ 6 times of its quality The ethanol of determining alcohol 70% ~ 80%, heating and refluxing extraction 2 ~ 3 times, extract 2 ~ 4h every time, extracting solution merges, filters, and previously obtained Filtration after Aqueous extracts merge, obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distillation of these component raw material medicine gross weight meter 5 ~ 7 times amount Water, decocts 2 ~ 4 hours, and filtration adds the distilled water of these component raw material medicine gross weight meter 5 ~ 7 times amount in medicinal residues, decocts 1 ~ 3 Hour, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05 ~ 0.1Mpa, vacuum be -0.02 ~ - Under conditions of 0.1Mpa, being concentrated into relative density at 60 DEG C is 1.1 ~ 1.3 clear paste, lets cool, and it is 70% ~ 80% that side adds determining alcohol Ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50% ~ 60% (V/V), stands overnight, filtration, filtering residue adds phase Determining alcohol for 2 ~ 4 times of its quality is 70% ~ 80% ethanol, is sufficiently stirred for, and filtration merges filtrate twice, and previously obtained First filtrate mixing, concentrating under reduced pressure removes solvent, obtains dry cream, is ground into powder, obtains dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality, being slowly added to The volatile oil of one step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4~1:5, and it is stirred continuously 1h ~ 2h, after cold preservation 24h, Filter, pulverize, obtain volatile oil embedded object；
4th step, dried cream powder, volatile oil embedded object is mixed homogeneously with disperse medium vegetable oil, is placed in wet granulator In, mix 3 ~ 8 minutes, make granule, send in vacuum drier and be vacuum dried, temperature of charge is 40 ~ 70 DEG C, vacuum For -0.08Mpa ~ -0.12Mpa, charging rate is 15 ~ 20L/h, and material strip transfer rate is 20 ~ 30cm/min, loads capsule, institute The mass ratio stating dried cream powder with described disperse medium is 1:1.5~2.5.
Present invention also offers above-mentioned Chinese medicine composition is used in the medicine treating chronic obstructive emphysema in preparation Application.
Present invention also offers a kind of Chinese medicinal composition granules for treating chronic obstructive emphysema, described granule The crude drug of agent includes Gecko, Semen Coiciss, Radix Pseudostellariae, Radix Glycyrrhizae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Semen Trigonellae, Caulis Spatholobi, Rhizoma Curcumae Longae, Fructus Hippophae, indigo plant Cloth just, Rhizoma Cynanchi Stauntonii, Fructus Forsythiae, Herba Inulae, Herba Ephedrae, Semen Myristicae, Cordyceps, Fructus Aristolochiae, Semen Euryaless, Thallus Laminariae (Thallus Eckloniae), Radix Curcumae, Pericarpium Citri Reticulatae, Resina Liquidambarises, Rhizoma Alpiniae Officinarum, Lignum Aquilariae Resinatum, the Rhizoma Anemarrhenae, Rhizoma Polygoni Cuspidati, Caulis Sargentodoxae,
The preparation method of described granule specifically,
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixing Thing, is subsequently added the distillation water retting 2h ~ 4h with respect to 6 ~ 8 times of mixture quality, pours in volatile oil extractor, the way of distillation carries Take volatile oil 4 ~ 6h, obtain volatile oil extracting solution, remaining Aqueous extracts filter, add in residue with respect to 4 ~ 6 times of its quality The ethanol of determining alcohol 70% ~ 80%, heating and refluxing extraction 2 ~ 3 times, extract 2 ~ 4h every time, extracting solution merges, filters, and previously obtained Filtration after Aqueous extracts merge, obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distillation of these component raw material medicine gross weight meter 5 ~ 7 times amount Water, decocts 2 ~ 4 hours, and filtration adds the distilled water of these component raw material medicine gross weight meter 5 ~ 7 times amount in medicinal residues, decocts 1 ~ 3 Hour, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05 ~ 0.1Mpa, vacuum be -0.02 ~ - Under conditions of 0.1Mpa, being concentrated into relative density at 60 DEG C is 1.1 ~ 1.3 clear paste, lets cool, and it is 70% ~ 80% that side adds determining alcohol Ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50% ~ 60% (V/V), stands overnight, filtration, filtering residue adds phase Determining alcohol for 2 ~ 4 times of its quality is 70% ~ 80% ethanol, is sufficiently stirred for, and filtration merges filtrate twice, and previously obtained First filtrate mixing, concentrating under reduced pressure removes solvent, obtains dry cream, is ground into powder, obtains dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality, being slowly added to The volatile oil of one step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4~1:5, and it is stirred continuously 1h ~ 2h, after cold preservation 24h, Filter, be spray-dried, pulverize, obtain volatile oil embedded object；
4th step, dried cream powder and the mixing of volatile oil embedded object are subsequently added dextrin and sucrose, with respect to 100 weight portions Dried cream powder, the addition of dextrin is 100 weight portion ~ 150 weight portions, and the addition of sucrose is 250 weight portion ~ 350 weight portions, It is placed in wet granulator, mixes 3 ~ 8 minutes, make granule, send in vacuum drier and be vacuum dried, temperature of charge is 40 ~ 70 DEG C, vacuum is -0.08Mpa ~ -0.12Mpa, and charging rate is 15 ~ 20L/h, and material strip transfer rate is 20 ~ 30cm/ Min, subpackage after being dried.
Present invention also offers a kind of Chinese medicine composition composition powders for treating chronic obstructive emphysema, described powder Crude drug include Gecko, Semen Coiciss, Radix Pseudostellariae, Radix Glycyrrhizae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Semen Trigonellae, Caulis Spatholobi, Rhizoma Curcumae Longae, Fructus Hippophae, Radix seu Herba Gei aleppici, Rhizoma Cynanchi Stauntonii, Fructus Forsythiae, Herba Inulae, Herba Ephedrae, Semen Myristicae, Cordyceps, Fructus Aristolochiae, Semen Euryaless, Thallus Laminariae (Thallus Eckloniae), Radix Curcumae, Pericarpium Citri Reticulatae, Resina Liquidambarises, Gao Liang Rhizoma Zingiberis Recens, Lignum Aquilariae Resinatum, the Rhizoma Anemarrhenae, Rhizoma Polygoni Cuspidati, Caulis Sargentodoxae,
The preparation method of described powder specifically,
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixing Thing, is subsequently added the distillation water retting 2h ~ 4h with respect to 6 ~ 8 times of mixture quality, pours in volatile oil extractor, the way of distillation carries Take volatile oil 4 ~ 6h, obtain volatile oil extracting solution, remaining Aqueous extracts filter, add in residue with respect to 4 ~ 6 times of its quality The ethanol of determining alcohol 70% ~ 80%, heating and refluxing extraction 2 ~ 3 times, extract 2 ~ 4h every time, extracting solution merges, filters, and previously obtained Filtration after Aqueous extracts merge, obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distillation of these component raw material medicine gross weight meter 5 ~ 7 times amount Water, decocts 2 ~ 4 hours, and filtration adds the distilled water of these component raw material medicine gross weight meter 5 ~ 7 times amount in medicinal residues, decocts 1 ~ 3 Hour, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05 ~ 0.1Mpa, vacuum be -0.02 ~ - Under conditions of 0.1Mpa, being concentrated into relative density at 60 DEG C is 1.1 ~ 1.3 clear paste, lets cool, and it is 70% ~ 80% that side adds determining alcohol Ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50% ~ 60% (V/V), stands overnight, filtration, filtering residue adds phase Determining alcohol for 2 ~ 4 times of its quality is 70% ~ 80% ethanol, is sufficiently stirred for, and filtration merges filtrate twice, and previously obtained First filtrate mixing, concentrating under reduced pressure removes solvent, obtains dry cream, be ground into dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality, being slowly added to The volatile oil of one step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4~1:5, and it is stirred continuously 1h ~ 2h, after cold preservation 24h, Filter, be spray-dried, pulverize, obtain volatile oil embedded object；
The volatile oil embedded object mixing that 4th step, the dried cream powder that obtain second step and the 3rd step obtain, sends into vacuum and does Be vacuum dried in dry machine, temperature of charge be 40 ~ 70 DEG C, vacuum be -0.08Mpa ~ -0.12Mpa, charging rate be 15 ~ 20L/h, material strip transfer rate is 20 ~ 30cm/min, sends into the powder being ground into 100 mesh ~ 200 mesh in pulverizer, and ultraviolet kills Poison, obtains powder.
Present invention also offers a kind of Chinese medicinal composition capsules agent for treating chronic obstructive emphysema, described capsule The crude drug of agent includes Gecko, Semen Coiciss, Radix Pseudostellariae, Radix Glycyrrhizae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Semen Trigonellae, Caulis Spatholobi, Rhizoma Curcumae Longae, Fructus Hippophae, indigo plant Cloth just, Rhizoma Cynanchi Stauntonii, Fructus Forsythiae, Herba Inulae, Herba Ephedrae, Semen Myristicae, Cordyceps, Fructus Aristolochiae, Semen Euryaless, Thallus Laminariae (Thallus Eckloniae), Radix Curcumae, Pericarpium Citri Reticulatae, Resina Liquidambarises, Rhizoma Alpiniae Officinarum, Lignum Aquilariae Resinatum, the Rhizoma Anemarrhenae, Rhizoma Polygoni Cuspidati, Caulis Sargentodoxae,
The preparation method of described capsule specifically,
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixing Thing, is subsequently added the distillation water retting 2h ~ 4h with respect to 6 ~ 8 times of mixture quality, pours in volatile oil extractor, the way of distillation carries Take volatile oil 4 ~ 6h, obtain volatile oil extracting solution, remaining Aqueous extracts filter, add in residue with respect to 4 ~ 6 times of its quality The ethanol of determining alcohol 70% ~ 80%, heating and refluxing extraction 2 ~ 3 times, extract 2 ~ 4h every time, extracting solution merges, filters, and previously obtained Filtration after Aqueous extracts merge, obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distillation of these component raw material medicine gross weight meter 5 ~ 7 times amount Water, decocts 2 ~ 4 hours, and filtration adds the distilled water of these component raw material medicine gross weight meter 5 ~ 7 times amount in medicinal residues, decocts 1 ~ 3 Hour, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05 ~ 0.1Mpa, vacuum be -0.02 ~ - Under conditions of 0.1Mpa, being concentrated into relative density at 60 DEG C is 1.1 ~ 1.3 clear paste, lets cool, and it is 70% ~ 80% that side adds determining alcohol Ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50% ~ 60% (V/V), stands overnight, filtration, filtering residue adds phase Determining alcohol for 2 ~ 4 times of its quality is 70% ~ 80% ethanol, is sufficiently stirred for, and filtration merges filtrate twice, and previously obtained First filtrate mixing, concentrating under reduced pressure removes solvent, obtains dry cream, is ground into powder, obtains dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality, being slowly added to The volatile oil of one step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4~1:5, and it is stirred continuously 1h ~ 2h, after cold preservation 24h, Filter, pulverize, obtain volatile oil embedded object；
4th step, dried cream powder, volatile oil embedded object is mixed homogeneously with disperse medium vegetable oil, is placed in wet granulator In, mix 3 ~ 8 minutes, make granule, send in vacuum drier and be vacuum dried, temperature of charge is 40 ~ 70 DEG C, vacuum For -0.08Mpa ~ -0.12Mpa, charging rate is 15 ~ 20L/h, and material strip transfer rate is 20 ~ 30cm/min, loads capsule, institute The mass ratio stating dried cream powder with described disperse medium is 1:1.5~2.5.
Beneficial effects of the present invention:
Provided by the present invention for treating the Chinese medicine composition of chronic obstructive emphysema, by adjusting pulmonary's work(of patient Can, improve inherent anti-virus ability, treating both the principal and secondary aspects of a disease, can fundamentally symptom management, delay the progress of the state of an illness, and realize controlling Treat, and with respect to Western medicine, it has good effect, instant effect, and to human zero damage, the state of an illness not repeatedly, has no drug resistance and the secondary work of poison With.
Specific embodiment
In Chinese medicine field, chronic obstructive emphysema belongs to " pulmonary distension " and the category of " dyspnea due to deficiency ", and its name of disease head sees《Yellow Warp in Supreme Being》, what " pulmonary distension " in the traditional Chinese medical science referred to is exactly emphysema it is believed that being that multiple chronic lung disease recurrent exerbation protracteds course of disease lead to lung Flatulence completely can not hold back fall so that airway constriction resistance increases, so being also called " obstruction of lung-QI ".Primary disease based on the dificiency of the lung due to protracted disease, In lung, continue then impact spleen, kidney, prolonged illness and the heart for sick position.Exopathogen violates lung repeatedly, long then the deficiency of the lung, pneumonopathy and spleen, causes deficiency of both lung and spleen, expectorant Turbid interior life, pneumonopathy and kidney, kidney qi is feeble and exhausted, failure of qi transforming fluid, and body fluid the moon turns to diseases caused by retention of fluid, and insufficiency of lung-QI can not promote the operation of painstaking effort, long Cause blood unsmooth, raw in blood stasis, eventually to expectorant turbid, diseases caused by retention of fluid, blood stasis interact, mutual inversion of phases.
The traditional Chinese medical science thinks that the etiology and pathogenesis of chronic obstructive emphysema lead to impairment of dispersing and descending function of the lung, frequently cough for exopathogen invasion and attack, causes The lung being damaged by lasted cough, pneumonopathy and spleen, kidney, because of the main literization of spleen, kidney governing water metabolism metabolism, when pneumonopathy disease and spleen, kidney, are mainly shown as expectorant Stagnation of QI knot and lower Jiao metabolism are unfavorable, whole then to blood stasis, diseases caused by retention of fluid, expectorant is turbid interacts, mutually and for sick.Therefore spleen, lung, the dirty work(of kidney three The basic pathogenesis for primary disease of lacking of proper care is located, and expectorant muddy water drink volt lung is the outward manifestation of primary disease, belongs to deficiency in origin mark this characteristic of disease more Real.
The traditional Chinese medical science thinks phlegm-blood stasis volt lung, the main pathological basis that air flue is jammed for primary disease.As《Danxi's experiential therapy is coughed》A piece is said: " pulmonary distension and cough, or left or right insomnia, it is disease that this expectorant folder congestion hinders gas ".
Expectorant is the main pathological product of primary disease, therefore, controls expectorant particularly important in the middle of primary disease treatment.According to《Gold is deficient will Slightly cough due to fluid-retention disease》A piece is pointed out：" sick phlegm retention person, when with warm medicine and it " this guiding theory, face more options mild medicine during card Thing.
Chronic obstructive emphysema due to lung qi block, lung network must the stasis of blood, therefore in the treatment note plus with acupuncture-stimulating blood stasis dispersing it Product, can promote the ventilatory function of lung more preferably to be improved.Lid qi being the governor of blood, gas row then blood, the stagnation of QI then blood stasis.
As can be seen here, the inherent pathogenesis of chronic obstructive emphysema can be summarized as lung spleen kidney deficiency, retention of phlegm and blood stasis in the lung, main pathology Factor is that expectorant is turbid and blood stasis, and both influence each other, and simultaneous sees with disease.
Insufficiency of lung-QI is the basic factor of chronic obstructive emphysema morbidity.Lung governing qi, master meter is defended outer.If insufficiency of lung-QI, outer Heresy attacks lung in an opponent's defence, and the pathogen of other internal organs, also easily pass in lung.Lung controlling dispersing outward and inwards, regulating fluid apssage, not normal, lung drops in deficiency of the lung a surname Gas superinverse, sending out is cough with asthma;If regulating fluid apssage is neglected one's duty, hydrops is expectorant., in lung, insufficiency of lung-QI is then no for chronic obstructive emphysema onset Power Guan Xinmai, cloth body fluid, gradually involve spleen kidney.When chronic obstructive emphysema sustainable development, due to spleen impaired renal function, and Insufficiency of lung-QI can be increased further, thus affecting the breathing of lung governing qi department, curing mainly section function towards hundred arteries and veins.Therefore, insufficiency of lung-QI directly affects The occurrence and development of chronic obstructive emphysema, its prosperity and decline is consistent with chronic obstructive emphysema state of an illness weight, and through slow Property obstructive emphysema the whole course of disease among, this disease disease position essentially consists in lung, and the pneumonopathy with the passing of time deficiency of vital energy appears, first pectoral qi metaplasia Not enough；Second impaired depurative descending of lung QI, vital essence loses cloth, final cause whole body qi of zang-fu viscera virtual loss.Meanwhile, pneumonopathy then functional activity of QI being not smooth, expectorant is turbid interior Raw, accumulateing heat, cloudy Tianjin of burning long, and cause the deficiency of YIN, deficiency of both QI and YIN.
Deficiency of spleen-QI is the key of Disease evolution, is that chronic obstructive emphysema gradually increases or the important turnover mitigating Point.Spleen autochthonal lung gold.It is impossible to by essence of water and grain spreading whole body, with limb muscle of supplementing nutrition, and it is very thin extremity for temper virtual loss, Pork will take off, and body can be led to more deficient, thus having influence on lung governing qi, the function of department's breathing further.The spleen being the source of producing phlegm, Lung is the device of storage expectorant.Temper virtual loss, are good for fortune mistake department, then water is wet stops the poly- expectorant that forms and become drink, also can affect lung qi a surname and drop.
Deficiency of kidney-QI is the final outcome of chronic obstructive emphysema development.The kidney being the root of QI, then gas loses and takes the photograph and receive void, and lung loses Respectful fall;The kidney being the origin of congenital constitution, interior residence nephroyin and nephroyang.The prolonged and repeated outbreak of chronic obstructive emphysema makes lung yin body fluid deficiency consume, Bai Jiu Female empty and son involves kidney yin；The main water of kidney, a surname that insufficiency of kidney-YANG also affects lung sends out respectful and drops and regulating fluid apssage function.
Lung spleen kidney deficiency is the intrinsic factor of chronic obstructive emphysema morbidity." the lung being the dominator of QI, the kidney being the root of QI ", " spleen Stomach is source of generating QI and blood ", to injure lung, kidney, spleen three chronic obstructive emphysema dirty more, therefore clinical common three dirty deficient cards Wait.
The turbid generation of expectorant in chronic obstructive emphysema, disease just by lung qi stasis, dysfunction of the spleen in transportation, body fluid not reforming and Become, gradually because the deficiency of the lung can not change Tianjin, insufficiency of the spleen can not transfer, kidney deficiency can not be evaporated, expectorant turbid more gambling stay, breathed with cough lasting difficulty.Prolong long Excess of YIN due to YANG-insufficiency, failure of qi transforming fluid, expectorant is to drink for water from cold transformation.Expectorant turbid storage lung, gesture is deep long for disease, and the deficiency of the lung can not administer the fortune adjusting painstaking effort OK, " heart master " operation overwork, the motive, deficiency of heart-YANG decline, and powerless promotion blood leads to blood stasis.Blood stasis stasis air flue, hinders mechanism of qi liter Fall comes in and goes out, and can Kui Erwei cough as breathing heavily.Blood stasis syndrome in chronic obstructive pulmonary disease is early in Chinese medical book description, its mechanism with The traditional Chinese medical science convergence of vessels in the lung is related, and modern medicine Physico-chemical tests means also confirm the presence of the stasis of blood.
Chronic obstructive emphysema pathogenesis is depression and stagnation of QI, phlegm and blood stasis.In fact, phlegm retention, blood stasis are in chronic obstruction Property emphysema in be pathological product and again paathogenic factor, so the two often mutually knot be disease, because expectorant causes the stasis of blood, because of stasis of blood cause Expectorant.They are all to produce on the basis of deficiency in origin.How by lung system illness with the passing of time chronic obstructive pulmonary disease, damages healthy energy, dirty Internal organs QI and blood dysfunction, causes depression and stagnation of QI, stagnation of phlegm air flue, phlegm and blood stasis and be the card of deficiency in origin and excess in superficiality, qi depression to blood stasis, phlegm-blood stasis are mutual Become chronic obstructive emphysema later stage common pathological.
Chronic obstructive emphysema recurrent exerbation, weakened body resistance do not transport, stasis and the stasis of blood, stop into expectorant in Tianjin, therefore phlegm retention, blood stain are chronic The pathological product of obstructive emphysema.But in turn, they, but also as the cause of disease, increase the state of an illness of chronic obstructive emphysema, Form vicious cycle.This runs through the development development of chronic obstructive emphysema all the time.
Theoretical based on above-mentioned Chinese traditional treatment, the present invention with tonification lung spleen kidney, removing toxic substances and promoting subsidence of swelling, diuretic clearing away phlegm, blood circulation promoting and blood stasis dispelling is Therapeutic Principle, proposes a kind of Chinese medicine composition for treating chronic obstructive emphysema, it includes following crude drug：Gecko, Semen Coiciss, Radix Pseudostellariae, Radix Glycyrrhizae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Semen Trigonellae, Caulis Spatholobi, Rhizoma Curcumae Longae, Fructus Hippophae, Radix seu Herba Gei aleppici, Rhizoma Cynanchi Stauntonii, Fructus Forsythiae, gold boiling Grass, Herba Ephedrae, Semen Myristicae, Cordyceps, Fructus Aristolochiae, Semen Euryaless, Thallus Laminariae (Thallus Eckloniae), Radix Curcumae, Pericarpium Citri Reticulatae, Resina Liquidambarises, Rhizoma Alpiniae Officinarum, Lignum Aquilariae Resinatum, the Rhizoma Anemarrhenae, tiger Cane, Caulis Sargentodoxae.
Preferably, described Chinese medicine composition is only made up of above-mentioned raw materials medicine.
Fang Zhong, Gecko lung benefiting gas, for controlling the key medicine of dyspnea due to deficiency chronic cough, the effect of antiasthmatic-antitussive can be played, Radix Pseudostellariae, Rhizoma Polygonati, indigo plant Cloth just can spleen reinforcing lung gas, Semen Coiciss enter stomach, lung, spleen channel, have eliminating dampness and diuresises, the function of strong activating the spleen lung, with solid the foundation of acquired constitution, Semen Myristicae, Fructus Schisandrae Chinensis astringe the lung gas and relieving cough and asthma, breath with cough key medicine for controlling the deficiency of the lung, and Semen Trigonellae is lost for nephrons void, gas receive under losing and Warming YANG helping inspiration to relieve asthma, Caulis Spatholobi nourshing blood and promoting blood circulation dredging collateral, to change the phlegm-blood stasis of interior knot, Rhizoma Curcumae Longae blood circulation promoting and blood stasis dispelling circulation of qi promoting, modern pharmacological research Prove that it has inhibitory action to the platelet aggregation of induction, and have depolymerisation to the platelet of gathering, additionally expansible Small artery, improves microcirculation, increases cerebral blood flow, cough-relieving sea-buckthorn resolving sputum, blood circulation promoting and blood stasis dispelling, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, Rhizoma Cynanchi Stauntonii eliminating the phlegm stops Cloperastine is breathed heavily, Herba Inulae wind-dispelling lung qi dispersing, sending down the abnormal ascending QI expectorant, promoting blood circulation and detumescence, Herba Ephedrae depressed lung-energy dispersing, inducing diuresis to remove edema, and Cordyceps tonifying the lung is solid Kidney, Fructus Aristolochiae lung heat clearing sending down the abnormal ascending QI, relieving cough and asthma, cool blood detumescence, Semen Euryaless supplementing the kidney to control the nocturnal, spleen reinforcing damp eliminating, Thallus Laminariae (Thallus Eckloniae) hard masses softening and resolving, expectorant profit Water, Radix Curcumae promoting flow of QI and blood, Pericarpium Citri Reticulatae, Lignum Aquilariae Resinatum are longer than qi-regulating and can enter spleen and lung, can go scattered sluggishness of lung-QI, but can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, sweetgum Fat promoting blood circulation and detoxication, dispelling wind and removing obstruction in the collateral, Rhizoma Alpiniae Officinarum improving inspiration by invigorating kidney-QI returns unit, Rhizoma Anemarrhenae clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, and Rhizoma Polygoni Cuspidati scattered stasis pain, resolving sputum stop Cough, Fructus Forsythiae dispersing swelling and dissipating binds, heat-clearing and toxic substances removing, Caulis Sargentodoxae heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, all medicines share, play tonification lung spleen kidney, removing toxic substances altogether Detumescence, diuretic clearing away phlegm, the work(of blood circulation promoting and blood stasis dispelling.
The Chinese medicine composition that the present invention provides can improve oxygen content, improves cardio-pulmonary function and microcirculation, thus mitigating Symptom, by temperature compensation lung kidney, warming YANG to promote diuresis, activating blood circulation to dissipate blood stasis, only cough with dyspnea, benefiting QI for activating blood circulation are integrated as Therapeutic Principle, both control Mark, consolidates again, fundamentally improves the state of an illness.
In described Chinese medicine composition, the weight portion of each crude drug is respectively：
Gecko 60 weight portion ~ 70 weight portion, Semen Coiciss 40 weight portion ~ 50 weight portion, Radix Pseudostellariae 100 weight portion ~ 110 weight Part, Radix Glycyrrhizae 35 weight portion ~ 45 weight portion, Rhizoma Polygonati 70 weight portion ~ 80 weight portion, Fructus Schisandrae Chinensis 50 weight portion ~ 60 weight portion, Semen Trigonellae 25 weight portion ~ 35 weight portions, Caulis Spatholobi 45 weight portion ~ 55 weight portion, Rhizoma Curcumae Longae 30 weight portion ~ 40 weight portion, Fructus Hippophae 35 weight portion ~ 45 weight portions, Radix seu Herba Gei aleppici 45 weight portion ~ 55 weight portion, Rhizoma Cynanchi Stauntonii 25 weight portion ~ 35 weight portion, Fructus Forsythiae 35 weight portion ~ 45 weight portion, Herba Inulae 40 weight portion ~ 50 weight portion, Herba Ephedrae 40 weight portion ~ 50 weight portion, Semen Myristicae 25 weight portion ~ 35 weight portion, worm summer in winter Careless 20 weight portion ~ 30 weight portions, Fructus Aristolochiae 30 weight portion ~ 40 weight portion, Semen Euryaless 30 weight portion ~ 40 weight portion, Thallus Laminariae (Thallus Eckloniae) 20 weight Part ~ 30 weight portions, Radix Curcumae 15 weight portion ~ 25 weight portion, Pericarpium Citri Reticulatae 30 weight portion ~ 40 weight portion, Resina Liquidambarises 25 weight portion ~ 35 weight Part, Rhizoma Alpiniae Officinarum 20 weight portion ~ 30 weight portion, Lignum Aquilariae Resinatum 20 weight portion ~ 30 weight portion, the Rhizoma Anemarrhenae 55 weight portion ~ 65 weight portion, Rhizoma Polygoni Cuspidati 75 Weight portion ~ 85 weight portion, Caulis Sargentodoxae 30 weight portion ~ 40 weight portion.
In described Chinese medicine composition, the weight portion of each crude drug is further preferably respectively：
Gecko 63 weight portion ~ 67 weight portion, Semen Coiciss 43 weight portion ~ 47 weight portion, Radix Pseudostellariae 103 weight portion ~ 107 weight Part, Radix Glycyrrhizae 38 weight portion ~ 42 weight portion, Rhizoma Polygonati 73 weight portion ~ 77 weight portion, Fructus Schisandrae Chinensis 53 weight portion ~ 57 weight portion, Semen Trigonellae 28 weight portion ~ 32 weight portions, Caulis Spatholobi 48 weight portion ~ 52 weight portion, Rhizoma Curcumae Longae 33 weight portion ~ 37 weight portion, Fructus Hippophae 38 weight portion ~ 42 weight portions, Radix seu Herba Gei aleppici 48 weight portion ~ 52 weight portion, Rhizoma Cynanchi Stauntonii 28 weight portion ~ 32 weight portion, Fructus Forsythiae 38 weight portion ~ 42 weight portion, Herba Inulae 43 weight portion ~ 47 weight portion, Herba Ephedrae 43 weight portion ~ 47 weight portion, Semen Myristicae 28 weight portion ~ 32 weight portion, worm summer in winter Careless 23 weight portion ~ 27 weight portions, Fructus Aristolochiae 33 weight portion ~ 37 weight portion, Semen Euryaless 33 weight portion ~ 37 weight portion, Thallus Laminariae (Thallus Eckloniae) 23 weight Part ~ 27 weight portions, Radix Curcumae 18 weight portion ~ 22 weight portion, Pericarpium Citri Reticulatae 33 weight portion ~ 37 weight portion, Resina Liquidambarises 28 weight portion ~ 32 weight Part, Rhizoma Alpiniae Officinarum 23 weight portion ~ 27 weight portion, Lignum Aquilariae Resinatum 23 weight portion ~ 27 weight portion, the Rhizoma Anemarrhenae 58 weight portion ~ 62 weight portion, Rhizoma Polygoni Cuspidati 78 Weight portion ~ 82 weight portion, Caulis Sargentodoxae 33 weight portion ~ 37 weight portion.
In described Chinese medicine composition, the weight portion of each crude drug is most preferably respectively：
Gecko 65 weight portion, Semen Coiciss 45 weight portion, Radix Pseudostellariae 105 weight portion, Radix Glycyrrhizae 40 weight portion, Rhizoma Polygonati 75 weight Part, Fructus Schisandrae Chinensis 55 weight portion, Semen Trigonellae 30 weight portion, Caulis Spatholobi 50 weight portion, Rhizoma Curcumae Longae 35 weight portion, Fructus Hippophae 40 weight portion, indigo plant Positive 50 weight portions of cloth, Rhizoma Cynanchi Stauntonii 30 weight portion, Fructus Forsythiae 40 weight portion, Herba Inulae 45 weight portion, Herba Ephedrae 45 weight portion, Semen Myristicae 30 weight Amount part, Cordyceps 25 weight portion, Fructus Aristolochiae 35 weight portion, Semen Euryaless 35 weight portion, Thallus Laminariae (Thallus Eckloniae) 25 weight portion, Radix Curcumae 20 weight portion, Pericarpium Citri Reticulatae 35 weight portion, Resina Liquidambarises 30 weight portion, Rhizoma Alpiniae Officinarum 25 weight portion, Lignum Aquilariae Resinatum 25 weight portion, the Rhizoma Anemarrhenae 60 weight portion, Rhizoma Polygoni Cuspidati 80 weight Amount part, Caulis Sargentodoxae 35 weight portion.
The pharmacology of each crude drug is as follows：
Gecko：Latin name Gecko, salty in the mouth, mild-natured, return lung, kidney channel, have invigorating the lung and the kidney, improving inspiration by invigorating kidney-QI Dingchuan, supporing yang benefit essence Effect, cures mainly the card such as lung kidney deficiency, dyspnea due to deficiency tachypnea, chronic cough hemoptysis, sexual impotence, seminal emission.
Semen Coiciss：Latin name Coicis Semen, sweet in the mouth, light, cold nature, enter lung, spleen, large intestine channel, there is invigorating the spleen to arrest diarrhea, Diuretic eliminating impediment, effect of row's skin ulcer pus, cure mainly having loose bowels of wet tired lung stomach；Damp invades the hydrosarca of stain skin, dysuria；Damp and hot Hinder the numbness in QI and blood to pass to and the card such as the scorchingly hot lung abscess pented up in lung intestinal, acute appendicitis.
Radix Pseudostellariae：Sweet in the mouth, slight bitter, mild-natured, enter spleen, lung meridian, there is air making-up and spleen enlivening, the effect of the lung moistening and production of body fluid promoting, for temper The weak, eat less and tired of deficiency of stomach-Yin, can strengthening the spleen gas, nourishing stomach-YIN, the deficiency of the lung cough caused by dryness for deficiency of vital energy Tianjin wound and cardiopalmus sleeplessness, deficiency-heat Hyperhidrosis, energy supplementing QI for promoting the production of body fluid, control deficiency of vital energy xeropulmonary cough, the cardiopalmus sleeplessness of deficiency of both QI and YIN, hyperhidrosis etc. are demonstrate,proved.
Radix Glycyrrhizae：Latin name Glycyrrhizae Radix et Rhizoma, sweet in the mouth, mild-natured, enter 12 warps, have heat clearing away solution Poison, mediation property of medicine, the effect of expelling phlegm for arresting cough, and energy nvigorating the spleen and in, relieving spasm to stop pain, are mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, Weak；Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugses, mitigate medicine to the toxic and side effects of body or Gastrointestinal is stimulated, QI invigorating neutralization, the effect of each component of mediation can be played by adding Radix Glycyrrhizae.
Rhizoma Polygonati：Sweet in the mouth, mild-natured, enter lung, spleen, kidney channel, there is nourishing kidney lung moistening, the effect of invigorating the spleen and replenishing QI, for lung-dryness syndrome due to deficiency of YIN, Dry cough expectorant is few, polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, deficiency of kidney essence, soreness of the waist and knees, and early whitening of beard and hair etc. is demonstrate,proved.
Fructus Schisandrae Chinensis：Latin name Schisandrae Chinensis Fructus, warm in nature, sour in the mouth, sweet, return lung, the heart, kidney channel, There is astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, effect of kidney calming, for chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, Spontaneous perspiration, night sweat, injury thirst, deficient pulse of losing heart, Heat Diabetes, palpitation and insomnia etc. is demonstrate,proved.
Semen Trigonellae：Latin name Trigonellae Semen, warm in nature, bitter in the mouth, there is kidney-replenishing, effect of dispelling cold and dampness, cure mainly Colic of cold type, abdomen coerces distension, the disturbance of lower legs due to pathogenic cold and dampness, the kidney deficiency soreness of waist, and sexual impotence etc. is demonstrate,proved.
Caulis Spatholobi：Latin name Spatholobi Caulis, bitter in the mouth, sweet, warm in nature, enter liver and kidney channel, have expansion of blood vessels, enrich blood Promoting blood circulation, regulating menstruation, effect of relaxing muscles and tendons and activating QI and blood in the collateral, there is obvious inhibitory action to platelet aggregation, promote animal kidney and uterus total phosphorus Metabolism, being mainly used in treatment blood deficiency has the menoxenia of silt, and limbs pain is meciless, and soreness of the waist and knees, pain etc. are demonstrate,proved.
Rhizoma Curcumae Longae：Bitter in the mouth, pungent, warm in nature, enter Liver Channel, there is blood-breaking, effect of inducing menstruation to relieve menalgia, twinge for chest side of body, close Warp, lump in the abdomen, rheumatism takes on arm pain, and tumbling and swelling etc. is demonstrate,proved.
Fructus Hippophae：Latin name Hippophae Fructus, sour in the mouth；Puckery；Warm in nature, there is relieving cough and resolving phlegm；Invigorating the stomach and promoting digestion；Promoting blood circulation Effect of dissipating blood stasis.Cure mainly cough with copious phlegm；Pulmonary abscess；Dyspepsia；Abdominal pain due to retention of food；Stomachache；Enteritis；Amenorrhea；Beat the stasis of blood swell etc. is demonstrate,proved.
Radix seu Herba Gei aleppici：Latin name Gei Herba, acrid in the mouth, hardship, mild-natured, Return liver, spleen, lung meridian, there is analgesia, blood pressure lowering, regulating menstruation, Effect of expelling wind and removing dampness, cures mainly hypertension, dizziness headache, menoxenia, lower abdominal pain, leucorrhea, infantile convulsion, rheumatism waist-leg Bitterly；Carbuncle furuncle poison is controlled in external, and traumatic injury etc. is demonstrate,proved.
Rhizoma Cynanchi Stauntonii：Latin name Cycanchi Stauntonii Rhizoma et Radix, acrid in the mouth, hardship, slightly warm in nature, return lung Warp, has a lowering the adverse-rising QI to resolve phlegm, the effect of cough-relieving, this moral character tepor and not dry strong, be longer than eliminating the phlegm, no matter fall lung qi, with flat cough with asthma, belongs to Cold genus heat, Exogenous and internal injuries, chronic cough of newly coughing all can use it,《Detailed outline》：Rhizoma Cynanchi Stauntonii, is longer than sending down the abnormal ascending QI, lung qi stop up the real and person that has expectorant preferably it.If Empty and long choking person is unavailable.Zhang Zhongjing is controlled and is coughed and deep pulse person, also uses it in Herba Euphorbiae Helioscopiae soup.
Fructus Forsythiae：Bitter in the mouth, cold nature, enter lung, the heart, small intestine meridian, there is heat-clearing and toxic substances removing, effect of dispersing swelling and dissipating binds, for calentura From the beginning of, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, ulcerative carbuncle pyogenic infections, acute nephritiss, pyretic stranguria.Mongolian medicine is controlled Jaundice, intestinal twinge etc. is demonstrate,proved, and Fructus Forsythiae is inhibited to various bacteria, has cooling effect to human body, and has obvious antiinflammatory Effect.
Herba Inulae：Latin name Inulae Herba, bitter in the mouth, pungent, salty, warm in nature, return lung, large intestine channel, have sending down the abnormal ascending QI, expectorant, Effect of row water, cures mainly affection of exogenous wind-cold, phlegm retention stores knot, cough and phlegm etc. is demonstrate,proved.
Herba Ephedrae：Acrid in the mouth, slight bitter, warm in nature, enter lung, bladder warp, have send out cold induce sweat, depressed lung-energy dispersing, the effect of inducing diuresis to remove edema, It is mainly used in the exterior excess syndromes such as the fever without perspiration of affection of exogenous wind-cold；Rheumatic arthralgia pain；Pathogenic cold attacking the lung or accumulation of heat in the lung are to cough with asthma QI rising in reverse order, water Swollen, dysuria etc. is demonstrate,proved.
Semen Myristicae：Latin name Myristicae Semen, acrid in the mouth, hardship, warm in nature, enter spleen, stomach, large intestine channel, there is warming middle-JIAO puckery Intestinal, the effect of promoting the circulation of qi helps digestion, the card such as do not disappear for diarrhea of deficiency type, cold-dysentery, abdominal distention, lack of appetite vomiting, dyspepsia.
Cordyceps：Sweet in the mouth, mild-natured, enter lung, kidney channel, there is kidney invigorating and YANG supporting, tonifying the lung is relievingd asthma, effect of hemostasis and phlegm, in Doctor thinks, Cordycepses enter lung kidney two warp, can tonifying the lung cloudy, and can kidney-replenishing, cure mainly kidney deficiency, impotence and seminal emission, soreness of waist and knee joint, empty after being ill Weak, chronic cough is weak, phthisical cough expectorant blood, spontaneous sweating etc., is a kind of unique Chinese medicine composition that can balance simultaneously, adjust negative and positive, Cure mainly senile chronic bronchitis, emphysema, pulmonary tuberculosis, bronchial asthma, shortness of breath of coughing, dyspnea due to deficiency is spat blood；Body void hidrosis, from Antiperspirant, night sweat；Eak after being ill, prolonged deficiency is not multiple, or the labor that declines is weak, and various chronic debilitating；Deficiency of kidney-QI, soreness of waist and knee joint, sun Flaccidity is passed out semen；Cancer；Diabetes patient, lupus erythematosus, chronic nephritiss and aplastic anemia and leukopenia etc. are demonstrate,proved.
Fructus Aristolochiae：Latin name Aristolochiae Fructus, bitter in the mouth, cold nature, return lung, large intestine channel, there is lung heat clearing fall Gas, relieving cough and asthma, bowel relieving disappears effects of hemorrhoid, and for dyspnea and cough due to lung-heat, sputum mixed with blood, the hot hemorrhoidal bleeding of intestinal, swelling and pain of hemorrhoid etc. is demonstrate,proved.
Semen Euryaless：Sweet in the mouth, puckery, mild-natured.Returns spleen, kidney channel.There is supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, the function of tonifying spleen and stopping diarrhea, cure mainly Emission, diarrhea due to hypofunction of the spleen, insufficiency of the spleen nebulousurine, carry inferior card.
Thallus Laminariae (Thallus Eckloniae)：Latin name Eckloniae Thallus, cold in nature, salty in the mouth, Return liver, stomach, kidney channel, there is hard masses softening and resolving, disappear Expectorant, effect of diuretic, cure mainly the card such as goiter, scrofula, painful and swollen testis, phlegm retention edema.
Radix Curcumae：Latin name Curcumae Radix, acrid in the mouth, hardship, cold in nature, Return liver, the heart, lung meridian, there is regulating qi to disperse stagnation, clear away heart-fire Resolving depression, effect of promoting the function of the gallbladder to alleviate jaundice, cure mainly closed dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice urine is red etc. Card.
Pericarpium Citri Reticulatae：Warm in nature, acrid in the mouth, hardship；Returns spleen, lung meridian, for diseases such as distension and fullness of the chest and abdomen.Pericarpium Citri tangerinae spread of pungent taste helps to keep warm, fragrant odour, long In qi-regulating, spleen and lung can be entered, therefore can go scattered sluggishness of lung-QI, but can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gather around stagnant, chest and diaphragm feeling of fullness and taste gas for lung qi The diseases such as stagnant, distension and fullness in the abdomen, have loose bowels for retention of dampness in middle-JIAO, gastral cavity abdomen ruffian is swollen, loose stool, and the card such as many coughs of phlegm.
Resina Liquidambarises：Latin name Liquidambaris Resina, acrid in the mouth, slight bitter, mild-natured, return lung, spleen channel, there is promoting blood circulation and stop Bitterly, removing toxic substances and promoting granulation, effect of cooling blood for hemostasis, cure mainly traumatic injury, ulcer sore pain, spit blood, traumatic hemorrhage etc. is demonstrate,proved.
Rhizoma Alpiniae Officinarum：Acrid in the mouth, property heat, returns spleen, stomach, there is warming stomach for dispelling cold, the effect of the pain relieving that helps digestion.For coldness and pain in the epigastrium, Gastrofrigid vomiting, belch acid regurgitation etc. is demonstrate,proved.
Lignum Aquilariae Resinatum：Latin name Aquilariae Lignum Resinatum, acrid in the mouth, hardship, slightly warm in nature, returns spleen, stomach, kidney channel, tool There are promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, effect of helping inspiration to relieve asthma, cure mainly chest and abdomen and rise vexed pain, gastrofrigid vomiting singultuss, kidney deficiency QI rising in reverse order dyspnea with rapid respiration Effect.
The Rhizoma Anemarrhenae：Bitter in the mouth, sweet, cold in nature, enter lung, stomach, kidney channel, have a relieving restlessness of purging heat, nourshing Yin and drynsessmoistening prescription, the effect of clearing away lung-heat to relieve cough, main Control fever caused by exogenous pathogenic factors, hyperpyrexia is irritated, lung-heat type cough, the symptom such as Heat Diabetes；Its bitter cold matter is moistened, and property settles, can heat clearing away, and can give birth to Tianjin, kind warm pathogenic factor of controlling enters edema caused by disorder of QI, intenseness of heat impairment of body fluid；It is also used for treating diabetess；Phlegm-heat obstructing in the lung and breathe heavily, xeropulmonary cough, expectorant is less not Profit；Hyperactivity of fire caused by deficiency of YIN, the symptom such as hyperactivity of deficient fire.
Rhizoma Polygoni Cuspidati：Latin name Polygoni Cuspidati Rhizoma et Radix, slight bitter, it is slightly cold.Return liver, gallbladder, lung Warp, has a heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, scattered stasis pain, effect of relieving cough and resolving phlegm, for arthralgia, damp and hot Huang Subcutaneous ulcer, amenorrhea, abdominal mass, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus etc. are demonstrate,proved.
Caulis Sargentodoxae：Latin name Sargentodoxae Caulis, bitter in the mouth, mild-natured, Return liver, large intestine channel, there is the eliminating carbuncle that relieves internal heat, Promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cure mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm Bitterly, the card such as injury from falling down.
The Chinese medicine composition that the present invention provides is oral traditional Chinese medicine composition, as needed, can prepare piece agent, flexible glue Any regular dosage form such as capsule, powder, granule, pill, mixture, can prepare it is preferable that Chinese medicine according to the conventional method of each dosage form The dosage form of compositionss is granule, capsule and powder.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is granule Agent, specially：
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixing Thing, is subsequently added the distillation water retting 2h ~ 4h with respect to 6 ~ 8 times of mixture quality, pours in volatile oil extractor, the way of distillation carries Take volatile oil 4 ~ 6h, obtain volatile oil extracting solution, remaining Aqueous extracts filter, add in residue with respect to 4 ~ 6 times of its quality The ethanol of determining alcohol 70% ~ 80%, heating and refluxing extraction 2 ~ 3 times, extract 2 ~ 4h every time, extracting solution merges, filters, and previously obtained Filtration after Aqueous extracts merge, obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distillation of these component raw material medicine gross weight meter 5 ~ 7 times amount Water, decocts 2 ~ 4 hours, and filtration adds the distilled water of these component raw material medicine gross weight meter 5 ~ 7 times amount in medicinal residues, decocts 1 ~ 3 Hour, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05 ~ 0.1Mpa, vacuum be -0.02 ~ - Under conditions of 0.1Mpa, being concentrated into relative density at 60 DEG C is 1.1 ~ 1.3 clear paste, lets cool, and it is 70% ~ 80% that side adds determining alcohol Ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50% ~ 60% (V/V), stands overnight, filtration, filtering residue adds phase Determining alcohol for 2 ~ 4 times of its quality is 70% ~ 80% ethanol, is sufficiently stirred for, and filtration merges filtrate twice, and previously obtained First filtrate mixing, concentrating under reduced pressure removes solvent, obtains dry cream, is ground into powder, obtains dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality, being slowly added to The volatile oil of one step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4~1:5, and it is stirred continuously 1h ~ 2h, after cold preservation 24h, Filter, be spray-dried, pulverize, obtain volatile oil embedded object；
4th step, dried cream powder and the mixing of volatile oil embedded object are subsequently added dextrin and sucrose, with respect to 100 weight portions Dried cream powder, the addition of dextrin is 100 weight portion ~ 150 weight portions, and the addition of sucrose is 250 weight portion ~ 350 weight portions, It is placed in wet granulator, mixes 3 ~ 8 minutes, make granule, send in vacuum drier and be vacuum dried, temperature of charge is 40 ~ 70 DEG C, vacuum is -0.08Mpa ~ -0.12Mpa, and charging rate is 15 ~ 20L/h, and material strip transfer rate is 20 ~ 30cm/ Min, subpackage after being dried, every bag of 5g.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, It is specially：
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixing Thing, is subsequently added the distillation water retting 2h ~ 4h with respect to 6 ~ 8 times of mixture quality, pours in volatile oil extractor, the way of distillation carries Take volatile oil 4 ~ 6h, obtain volatile oil extracting solution, remaining Aqueous extracts filter, add in residue with respect to 4 ~ 6 times of its quality The ethanol of determining alcohol 70% ~ 80%, heating and refluxing extraction 2 ~ 3 times, extract 2 ~ 4h every time, extracting solution merges, filters, and previously obtained Filtration after Aqueous extracts merge, obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distillation of these component raw material medicine gross weight meter 5 ~ 7 times amount Water, decocts 2 ~ 4 hours, and filtration adds the distilled water of these component raw material medicine gross weight meter 5 ~ 7 times amount in medicinal residues, decocts 1 ~ 3 Hour, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05 ~ 0.1Mpa, vacuum be -0.02 ~ - Under conditions of 0.1Mpa, being concentrated into relative density at 60 DEG C is 1.1 ~ 1.3 clear paste, lets cool, and it is 70% ~ 80% that side adds determining alcohol Ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50% ~ 60% (V/V), stands overnight, filtration, filtering residue adds phase Determining alcohol for 2 ~ 4 times of its quality is 70% ~ 80% ethanol, is sufficiently stirred for, and filtration merges filtrate twice, and previously obtained First filtrate mixing, concentrating under reduced pressure removes solvent, obtains dry cream, be ground into dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality, being slowly added to The volatile oil of one step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4~1:5, and it is stirred continuously 1h ~ 2h, after cold preservation 24h, Filter, be spray-dried, pulverize, obtain volatile oil embedded object；
The volatile oil embedded object mixing that 4th step, the dried cream powder that obtain second step and the 3rd step obtain, sends into vacuum and does Be vacuum dried in dry machine, temperature of charge be 40 ~ 70 DEG C, vacuum be -0.08Mpa ~ -0.12Mpa, charging rate be 15 ~ 20L/h, material strip transfer rate is 20 ~ 30cm/min, sends into the powder being ground into 100 mesh ~ 200 mesh in pulverizer, and ultraviolet kills Poison, obtains powder.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is capsule Agent, specially：
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixing Thing, is subsequently added the distillation water retting 2h ~ 4h with respect to 6 ~ 8 times of mixture quality, pours in volatile oil extractor, the way of distillation carries Take volatile oil 4 ~ 6h, obtain volatile oil extracting solution, remaining Aqueous extracts filter, add in residue with respect to 4 ~ 6 times of its quality The ethanol of determining alcohol 70% ~ 80%, heating and refluxing extraction 2 ~ 3 times, extract 2 ~ 4h every time, extracting solution merges, filters, and previously obtained Filtration after Aqueous extracts merge, obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distillation of these component raw material medicine gross weight meter 5 ~ 7 times amount Water, decocts 2 ~ 4 hours, and filtration adds the distilled water of these component raw material medicine gross weight meter 5 ~ 7 times amount in medicinal residues, decocts 1 ~ 3 Hour, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05 ~ 0.1Mpa, vacuum be -0.02 ~ - Under conditions of 0.1Mpa, being concentrated into relative density at 60 DEG C is 1.1 ~ 1.3 clear paste, lets cool, and it is 70% ~ 80% that side adds determining alcohol Ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50% ~ 60% (V/V), stands overnight, filtration, filtering residue adds phase Determining alcohol for 2 ~ 4 times of its quality is 70% ~ 80% ethanol, is sufficiently stirred for, and filtration merges filtrate twice, and previously obtained First filtrate mixing, concentrating under reduced pressure removes solvent, obtains dry cream, is ground into powder, obtains dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6 ~ 8 times of its quality, being slowly added to The volatile oil of one step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4~1:5, and it is stirred continuously 1h ~ 2h, after cold preservation 24h, Filter, pulverize, obtain volatile oil embedded object；
4th step, dried cream powder, volatile oil embedded object is mixed homogeneously with disperse medium vegetable oil, is placed in wet granulator In, mix 3 ~ 8 minutes, make granule, send in vacuum drier and be vacuum dried, temperature of charge is 40 ~ 70 DEG C, vacuum For -0.08Mpa ~ -0.12Mpa, charging rate is 15 ~ 20L/h, and material strip transfer rate is 20 ~ 30cm/min, loads capsule, often Grain 0.40g, described dried cream powder is 1: 1.5 ~ 2.5 with the mass ratio of described disperse medium.
Present invention also offers above-mentioned Chinese medicine composition is used in the medicine treating chronic obstructive emphysema in preparation Application.
Hereinafter embodiments of the present invention are described in detail using embodiment, whereby to the present invention how application technology means To solve technical problem, and reach realizing process and fully understanding and implement according to this of technique effect.
The concrete preparation of embodiment 1 granule 1
By Radix Pseudostellariae 105g, Rhizoma Polygonati 75g, Fructus Schisandrae Chinensis 55g, Radix seu Herba Gei aleppici 50g, Cordyceps 25g, Semen Euryaless 35g mixing, obtain Mixture, is subsequently added the distillation water retting 4h of 1.9kg, pours in volatile oil extractor, and the way of distillation extracts volatile oil 6h, obtains Volatile oil extracting solution, remaining Aqueous extracts filter, and add the ethanol of the determining alcohol 80% of 1.2kg, heating and refluxing extraction 3 in residue Secondary, extract 3h every time, extracting solution merges, filters, and merges with the Aqueous extracts after previously obtained filtration, obtains the first filtrate, By Gecko 65g, Semen Coiciss 45g, Radix Glycyrrhizae 40g, Semen Trigonellae 30g, Caulis Spatholobi 50g, Rhizoma Curcumae Longae 35g, Fructus Hippophae 40g, Rhizoma Cynanchi Stauntonii 30g, Fructus Forsythiae 40g, Herba Inulae 45g, Herba Ephedrae 45g, Semen Myristicae 30g, Fructus Aristolochiae 35g, Thallus Laminariae (Thallus Eckloniae) 25g, Radix Curcumae 20g, Pericarpium Citri Reticulatae 35g, Resina Liquidambarises 30g, Rhizoma Alpiniae Officinarum 25g, Lignum Aquilariae Resinatum 25g, Rhizoma Anemarrhenae 60g, Rhizoma Polygoni Cuspidati 80g, Caulis Sargentodoxae 35g mixing, add the distilled water of 6kg, decoct 4 hours, filter Cross, medicinal residues add the distilled water of 6kg, decoct 2 hours, filtration, merging filtrate, is 60 in thickening temperature, and steam pressure is 0.1Mpa, under conditions of vacuum is -0.1Mpa, is concentrated into the clear paste that relative density at 60 DEG C is 1.2, lets cool, and side adds alcohol Concentration stirs for 80% ethanol side and accounts for overall solution volume to ethanol volumn concentration is 60% (V/V), stands overnight, filtration, filter The determining alcohol that slag adds 500g is 80% ethanol, is sufficiently stirred for, and filtration merges filtrate twice, mixes with the first previously obtained filtrate Close, concentrating under reduced pressure removes solvent, obtain dry cream, be ground into powder, obtain the dried cream powder of 1kg, by beta-schardinger dextrin-with respect to it After the distilled water heating for dissolving of 7 times of quality is complete, it is slowly added to volatile oil prepared above, the quality of volatile oil and beta-schardinger dextrin- Than for 1:5, and be stirred continuously 2h, after cold preservation 24h, filter, be spray-dried, pulverize, obtain volatile oil embedded object, by dried cream powder and Volatile oil embedded object mixes, and is subsequently added the dextrin of 1kg and the sucrose of 3kg, is placed in wet granulator, mixes 8 minutes, makes Granule, sends in vacuum drier and is vacuum dried, and temperature of charge is 50 DEG C, and vacuum is -0.1Mpa, and charging rate is 20L/h, material strip transfer rate is 30cm/min, subpackage after being dried, every bag of 5g.
The concrete preparation of embodiment 2 granule 2
By Radix Pseudostellariae 100g, Rhizoma Polygonati 70g, Fructus Schisandrae Chinensis 50g, Radix seu Herba Gei aleppici 45g, Cordyceps 20g, Semen Euryaless 30g mixing, obtain Mixture, is subsequently added the distillation water retting 4h of 2.4kg, pours in volatile oil extractor, and the way of distillation extracts volatile oil 6h, obtains Volatile oil extracting solution, remaining Aqueous extracts filter, and add the ethanol of the determining alcohol 80% of 1.5kg, heating and refluxing extraction 3 in residue Secondary, extract 3h every time, extracting solution merges, filters, and merges with the Aqueous extracts after previously obtained filtration, obtains the first filtrate, By Gecko 60g, Semen Coiciss 40g, Radix Glycyrrhizae 35g, Semen Trigonellae 25g, Caulis Spatholobi 45g, Rhizoma Curcumae Longae 30g, Fructus Hippophae 35g, Rhizoma Cynanchi Stauntonii 25g, Fructus Forsythiae 35g, Herba Inulae 40g, Herba Ephedrae 40g, Semen Myristicae 25g, Fructus Aristolochiae 30g, Thallus Laminariae (Thallus Eckloniae) 20g, Radix Curcumae 15g, Pericarpium Citri Reticulatae 30g, Resina Liquidambarises 25g, Rhizoma Alpiniae Officinarum 20g, Lignum Aquilariae Resinatum 20g, Rhizoma Anemarrhenae 55g, Rhizoma Polygoni Cuspidati 75g, Caulis Sargentodoxae 30g mixing, add the distilled water of 5.2kg, decoct 4 hours, Filtration, adds the distilled water of 5.2kg in medicinal residues, decocts 2 hours, filtration, and merging filtrate is 60 DEG C in thickening temperature, steam Pressure is 0.1Mpa, under conditions of vacuum is -0.1Mpa, is concentrated into the clear paste that relative density at 60 DEG C is 1.2, lets cool, side Add determining alcohol to stir for 75% ethanol side and account for overall solution volume for 55% (V/V) to ethanol volumn concentration, stand overnight, filter Cross, the determining alcohol that filtering residue adds 500g is 80% ethanol, is sufficiently stirred for, filtration merges filtrate twice, with the first previously obtained mistake Filtrate mixes, and concentrating under reduced pressure removes solvent, obtains dry cream, is ground into powder, obtains the dried cream powder of 800g, by beta-schardinger dextrin-phase For 7 times of distilled water heating for dissolving of its quality complete after, be slowly added to volatile oil prepared above, volatile oil and beta-schardinger dextrin- Mass ratio be 1:4, and it is stirred continuously 2h, after cold preservation 24h, filter, be spray-dried, pulverize, obtain volatile oil embedded object, will do Cream powder and the mixing of volatile oil embedded object, are subsequently added the dextrin of 800g and the sucrose of 2.5kg, are placed in wet granulator, mix 8 Minute, make granule, send in vacuum drier and be vacuum dried, temperature of charge is 50 DEG C, vacuum pressure is -0.1Mpa, Charging rate is 20L/h, and material strip transfer rate is 30cm/min, subpackage after being dried, every bag of 5g.
The concrete preparation of embodiment 3 granule 3
By Radix Pseudostellariae 110g, Rhizoma Polygonati 80g, Fructus Schisandrae Chinensis 60g, Radix seu Herba Gei aleppici 65g, Cordyceps 30g, Semen Euryaless 40g mixing, obtain Mixture, is subsequently added the distillation water retting 4h of 2.7kg, pours in volatile oil extractor, and the way of distillation extracts volatile oil 6h, obtains Volatile oil extracting solution, remaining Aqueous extracts filter, and add the ethanol of the determining alcohol 80% of 1.8kg, heating and refluxing extraction 3 in residue Secondary, extract 3h every time, extracting solution merges, filters, and merges with the Aqueous extracts after previously obtained filtration, obtains the first filtrate, By Gecko 70g, Semen Coiciss 50g, Radix Glycyrrhizae 45g, Semen Trigonellae 35g, Caulis Spatholobi 55g, Rhizoma Curcumae Longae 40g, Fructus Hippophae 45g, Rhizoma Cynanchi Stauntonii 35g, Fructus Forsythiae 45g, Herba Inulae 50g, Herba Ephedrae 50g, Semen Myristicae 35g, Fructus Aristolochiae 40g, Thallus Laminariae (Thallus Eckloniae) 30g, Radix Curcumae 25g, Pericarpium Citri Reticulatae 40g, Resina Liquidambarises 35g, Rhizoma Alpiniae Officinarum 30g, Lignum Aquilariae Resinatum 30g, Rhizoma Anemarrhenae 65g, Rhizoma Polygoni Cuspidati 85g, Caulis Sargentodoxae 40g mixing, add the distilled water of 6.8kg, decoct 4 hours, Filtration, adds the distilled water of 6.8kg in medicinal residues, decocts 2 hours, filtration, and merging filtrate is 60 DEG C in thickening temperature, steam Pressure is 0.1Mpa, under conditions of vacuum is -0.1Mpa, is concentrated into the clear paste that relative density at 60 DEG C is 1.2, lets cool, side Add determining alcohol to stir for 75% ethanol side and account for overall solution volume for 55% (V/V) to ethanol volumn concentration, stand overnight, filter Cross, the determining alcohol that filtering residue adds 500g is 80% ethanol, is sufficiently stirred for, filtration merges filtrate twice, with the first previously obtained mistake Filtrate mixes, and concentrating under reduced pressure removes solvent, obtains dry cream, is ground into powder, obtains the dried cream powder of 1kg, by beta-schardinger dextrin-phase For 7 times of distilled water heating for dissolving of its quality complete after, be slowly added to volatile oil prepared above, volatile oil and beta-schardinger dextrin- Mass ratio be 1:4, and it is stirred continuously 2h, after cold preservation 24h, filter, be spray-dried, pulverize, obtain volatile oil embedded object, will do Cream powder and the mixing of volatile oil embedded object, are subsequently added the dextrin of 1kg and the sucrose of 3kg, are placed in wet granulator, mix 8 points Clock, makes granule, sends in vacuum drier and is vacuum dried, and temperature of charge is 50 DEG C, and vacuum pressure is -0.1Mpa, enters Material speed is 20L/h, and material strip transfer rate is 30cm/min, subpackage after being dried, every bag of 5g.
The concrete preparation of embodiment 4 powder 1
By Radix Pseudostellariae 105g, Rhizoma Polygonati 75g, Fructus Schisandrae Chinensis 55g, Radix seu Herba Gei aleppici 50g, Cordyceps 25g, Semen Euryaless 35g mixing, obtain Mixture, is subsequently added the distillation water retting 4h of 1.9kg, pours in volatile oil extractor, and the way of distillation extracts volatile oil 6h, obtains Volatile oil extracting solution, remaining Aqueous extracts filter, and add the ethanol of the determining alcohol 80% of 1.2kg, heating and refluxing extraction 3 in residue Secondary, extract 3h every time, extracting solution merges, filters, and merges with the Aqueous extracts after previously obtained filtration, obtains the first filtrate, By Gecko 65g, Semen Coiciss 45g, Radix Glycyrrhizae 40g, Semen Trigonellae 30g, Caulis Spatholobi 50g, Rhizoma Curcumae Longae 35g, Fructus Hippophae 40g, Rhizoma Cynanchi Stauntonii 30g, Fructus Forsythiae 40g, Herba Inulae 45g, Herba Ephedrae 45g, Semen Myristicae 30g, Fructus Aristolochiae 35g, Thallus Laminariae (Thallus Eckloniae) 25g, Radix Curcumae 20g, Pericarpium Citri Reticulatae 35g, Resina Liquidambarises 30g, Rhizoma Alpiniae Officinarum 25g, Lignum Aquilariae Resinatum 25g, Rhizoma Anemarrhenae 60g, Rhizoma Polygoni Cuspidati 80g, Caulis Sargentodoxae 35g mixing, add the distilled water of 6kg, decoct 4 hours, filter Cross, medicinal residues add the distilled water of 6kg, decoct 2 hours, filtration, merging filtrate, is 60 in thickening temperature, and steam pressure is 0.1Mpa, under conditions of vacuum is -0.1Mpa, is concentrated into the clear paste that relative density at 60 DEG C is 1.2, lets cool, and side adds alcohol Concentration stirs for 80% ethanol side and accounts for overall solution volume to ethanol volumn concentration is 60% (V/V), stands overnight, filtration, filter The determining alcohol that slag adds 500g is 80% ethanol, is sufficiently stirred for, and filtration merges filtrate twice, mixes with the first previously obtained filtrate Close, concentrating under reduced pressure removes solvent, obtain dry cream, be ground into powder, obtain the dried cream powder of 1kg, by beta-schardinger dextrin-with respect to it After the distilled water heating for dissolving of 7 times of quality is complete, it is slowly added to volatile oil prepared above, the quality of volatile oil and beta-schardinger dextrin- Than for 1:5, and be stirred continuously 2h, after cold preservation 24h, filter, be spray-dried, pulverize, obtain volatile oil embedded object, by dried cream powder and Volatile oil embedded object mix, send into vacuum drier in be vacuum dried, temperature of charge be 50 DEG C, vacuum be- 0.12Mpa, charging rate is 20L/h, and material strip transfer rate is 20cm/min, sends into the powder being ground into 150 mesh in pulverizer, Ultraviolet is killed virus, and obtains powder 1.
The concrete preparation of embodiment 5 capsule 1
By Radix Pseudostellariae 105g, Rhizoma Polygonati 75g, Fructus Schisandrae Chinensis 55g, Radix seu Herba Gei aleppici 50g, Cordyceps 25g, Semen Euryaless 35g mixing, obtain Mixture, is subsequently added the distillation water retting 4h of 1.9kg, pours in volatile oil extractor, and the way of distillation extracts volatile oil 6h, obtains Volatile oil extracting solution, remaining Aqueous extracts filter, and add the ethanol of the determining alcohol 80% of 1.2kg, heating and refluxing extraction 3 in residue Secondary, extract 3h every time, extracting solution merges, filters, and merges with the Aqueous extracts after previously obtained filtration, obtains the first filtrate, By Gecko 65g, Semen Coiciss 45g, Radix Glycyrrhizae 40g, Semen Trigonellae 30g, Caulis Spatholobi 50g, Rhizoma Curcumae Longae 35g, Fructus Hippophae 40g, Rhizoma Cynanchi Stauntonii 30g, Fructus Forsythiae 40g, Herba Inulae 45g, Herba Ephedrae 45g, Semen Myristicae 30g, Fructus Aristolochiae 35g, Thallus Laminariae (Thallus Eckloniae) 25g, Radix Curcumae 20g, Pericarpium Citri Reticulatae 35g, Resina Liquidambarises 30g, Rhizoma Alpiniae Officinarum 25g, Lignum Aquilariae Resinatum 25g, Rhizoma Anemarrhenae 60g, Rhizoma Polygoni Cuspidati 80g, Caulis Sargentodoxae 35g mixing, add the distilled water of 6kg, decoct 4 hours, filter Cross, medicinal residues add the distilled water of 6kg, decoct 2 hours, filtration, merging filtrate, is 60 in thickening temperature, and steam pressure is 0.1Mpa, under conditions of vacuum is -0.1Mpa, is concentrated into the clear paste that relative density at 60 DEG C is 1.2, lets cool, and side adds alcohol Concentration stirs for 80% ethanol side and accounts for overall solution volume to ethanol volumn concentration is 60% (V/V), stands overnight, filtration, filter The determining alcohol that slag adds 500g is 80% ethanol, is sufficiently stirred for, and filtration merges filtrate twice, mixes with the first previously obtained filtrate Close, concentrating under reduced pressure removes solvent, obtain dry cream, be ground into powder, obtain the dried cream powder of 800kg, by beta-schardinger dextrin-with respect to After the distilled water heating for dissolving of 7 times of its quality is complete, it is slowly added to the volatile oil of first step preparation, volatile oil and beta-schardinger dextrin- Mass ratio is 1:5, and it is stirred continuously 2h, after cold preservation 24h, filter, be spray-dried, pulverize, obtain volatile oil embedded object, by 800g Dried cream powder and the mixing of volatile oil embedded object, are mixed homogeneously with the disperse medium vegetable oil of 1.6kg, are placed in wet granulator, mix To close 8 minutes, make granule, send in vacuum drier and be vacuum dried, temperature of charge is 60 DEG C, vacuum is- 0.08Mpa, charging rate is 18L/h, and material strip transfer rate is 25cm/min, loads capsule, every 0.40g.
Embodiment 6 Drug toxicity trails are analyzed
Acute toxicity testing
Kunming mice 50 (is provided by Qingdao City's laboratory animal and animal experimental center), female half and half, and body weight 18～ 22g, is divided into 5 groups, every group 10, the granule 1 of the 1st group of gavage embodiment of the present invention 1 preparation, and the 2nd group of gavage present invention is implemented The granule 2 of example 2 preparation, the granule 3 of the 3rd group of gavage embodiment of the present invention 3 preparation, gavage method is to be dissolved in granule In water, stirring and dissolving completely, obtains the solution that crude drug concentration is 1g/ml, the powder of the 4th group of gavage embodiment of the present invention 4 preparation 1, gavage method is to be dissolved in water powder, and stirring and dissolving completely, obtains the solution that crude drug concentration is 1g/ml, the 5th group of gavage The capsule 1 of the embodiment of the present invention 5 preparation, gavage method is to be dissolved in water capsule, and stirring and dissolving completely, obtains crude drug Concentration is the solution of 1g/ml, and by 5 groups of dosage gastric infusions press 10g (crude drug)/kg, observation after gavage has no for 72 hours Dead mouse, shows that Chinese medicine composition dosis tolerata of the present invention is big, LD50Do not measure.
Long term toxicity test
Cavia porcelluss 60 (are provided by Qingdao City's laboratory animal and animal experimental center), male and female half and half, body weight be 250g ~ 300g, is divided into 6 groups, every group 10, the granule 1 of the 1st group of gavage embodiment of the present invention 1 preparation, and the 2nd group of gavage present invention is implemented The granule 2 of example 2 preparation, the granule 3 of the 3rd group of gavage embodiment of the present invention 3 preparation, gavage method is to be dissolved in granule In water, stirring and dissolving completely, obtains the solution that crude drug concentration is 1g/ml, the powder of the 4th group of gavage embodiment of the present invention 4 preparation 1, gavage method is to be dissolved in water powder, and stirring and dissolving completely, obtains the solution that crude drug concentration is 1g/ml, the 5th group of gavage The capsule 1 of the embodiment of the present invention 5 preparation, gavage method is to be dissolved in water capsule, and stirring and dissolving completely, obtains crude drug Concentration is the solution of 1g/ml, by 5 groups of dosage gastric infusions pressing 10g (crude drug)/g, the 6th group as blank control group, in 3 the end of month make hemoglobin, red, numeration of leukocyte, leukocyte differential count, platelet count, bleeding and cotting time, Liver and kidney function Detection and the case control of important organ, the body weight through 1,2,3 the end of month Dynamic Weighting medication groups and each group Cavia porcelluss before and after experiment, Have no significant difference between each group, make Cavia porcelluss hemoglobin, red, numeration of leukocyte, leukocyte differential count, blood with testing rear 3 the end of month Platelet number, bleeding and cotting time, Liver and kidney function inspection, medication group and blank control group relatively have no significant difference, liver, kidney, The heart, the pathomorphology inspection of brain, both results similar it was demonstrated that this Chinese medicine composition avirulence.
Embodiment 7 zoopery
Animal packet and model preparation
W istar rat 36 (is provided by Qingdao City's laboratory animal and animal experimental center), male and female half and half, and body weight is 250g ~ 300g, 12 weeks Mus ages.Animal is randomly divided into three groups, each 12, room temperature conventinal breeding.Matched group：Do not do any place Reason.Experimental chronic obstructive emphysema model group (abbreviation model group)：1st, 14,28 days through tail vein injection endotoxin 3mg/ Kg, (except the 14th, 28 days) are inserted rat in lucite storehouse (smoking contamination device) and are carried out passive smoking within the 2nd～45 day, and 2 Secondary/d, 12/time, continue 30min, 2 minor tick 4h, the common 45d of whole modeling process.Treatment group：The same model of model preparation method Group, before the 1st～30 day daily fumigation or endotoxin injection 0.5h gavage the embodiment of the present invention 1 preparation granule 1, continuous 30d, Gavage method is to be dissolved in water granule, and stirring and dissolving completely, obtains the solution that crude drug concentration is 1g/ml.
Pulmonary function, cytokine, coagulant and fibrinolytic function detection and pathologic inspection method
After model preparation, measure each group pulmonary function.Peel off rat aorta and take blood, use Enzyme-linked immunosorbent assay Method (ELISA) measures tumor necrosis factor (TNF-α), IL-6, IL-8, IL- in serum and bronchoalveolar lavage fluid (BALF) 10 and serum tissue type plasminogen activator (tPA), PAI-1 (PA I-1), plasma tissue factor Pathway inhibitor antigen (TFP I:Ag), Chromogenic assay measures Antithrombin III (AT- III) activity.Take every rat Trachea section structure at 0.5cm on lower right lobe (maximum transverse diameter about 3mm) and trachea bifurcated, paraffin is fixed, and HE dyes, light microscopic Observe.
Statistical method
Measurement data is represented using X ± s, compares and adopt χ between group2Inspection, all data all count soft using SPSS12.0 Part is processed.
Result
Lung function index compares, and the results are shown in Table 1.
1 three groups of lung function index of table
Group MVV(ml) FEV0.2/FVC(%) Re(cmH2O)
Matched group 127.93±3.18 89.01±4.73 2.65±0.53
Model group 182.17±4.02 63.91±3.87 3.79±0.61
Treatment group 131.55±3.69 88.63±3.29 2.82±0.52
Note：Re is airway resistance
As it can be seen from table 1 lung airway resistance (Re), firmly lung can be obviously improved using the Chinese medicine composition of the present invention Ventilatory function (PVC), logical atm number (MVV) per minute, thus prove pulmonary function is had preferable effect.
Blood-serum IL-8, IL-10, TNF-α level compare, and the results are shown in Table 2.
Table 2 Blood-serum IL-8, IL-10, TNF-α level compare (pg/ml)
Group IL-8 IL-10 TNF-α
Matched group 4.91±0.37 24.51±2.91 10.23±1.05
Model group 13.62±1.16 12.71±1.93 23.04±2.77
Treatment group 5.99±0.73 25.03±1.27 12.01±1.16
In BALF, IL-6, IL-8 level compares, and the results are shown in Table 3.
In table 3BALF, IL-6, IL-8 level compares (pg/ml)
Group IL-8 IL-6
Matched group 6.02±0.71 17.26±1.38
Model group 16.19±2.44 35.14±3.85
Treatment group 9.28±0.49 26.53±4.06
From table 2 and table 3 as can be seen that the Chinese medicine composition of the present invention can significantly reduce inflammatory reaction and improve blood flow Mechanics is it was demonstrated that it has good antiinflammatory action.
Coagulant and fibrinolytic function compares, and the results are shown in Table 4.
Table 4 coagulant and fibrinolytic function compares
Group AT-Ⅲ(%) TFPI(ng/ml) tPA(ng/ml) PA I-1(ng/ml)
Matched group 87.66±5.03 1.07±0.39 1.49±0.36 0.93±0.18
Model group 57.25±6.11 1.49±0.51 2.03±0.58 0.47±0.09
Treatment group 79.35±4.02 1.37±0.73 1.71±0.29 1.21±0.31
From table 4, it can be seen that antithrombin -Ⅲ can substantially be increased using the Chinese medicine composition of the present invention, reduce blood little The gathering of plate and sticking, improves hypercoagulability, can delay the formation of obstructive emphysema pathological lesion.
Embodiment 8 clinical data
Physical data
156 patients are all with reference to the formulation of respiratory disease association of Chinese Medical Association《Chronic obstructive pulmonary disease diagnosis and treatment guide》Really Examine as chronic obstructive emphysema.Patient is randomly divided into matched group and treatment group, treatment group 83, wherein, male 50, female 33 Example；Oldest 73 years old, minimum for 36 years old, average out to（47.2±2.83）Year；The course of disease 3～19 years, averagely（10.6± 3.27）Year.Matched group 73, wherein, man 45, female 28；Oldest 71 years old, minimum for 39 years old, average out to（45.2 ±3.41）Year；The course of disease 3～17 years, averagely（9.4±3.58）Year.Two groups of patients are in age, sex, state of an illness weight and course of disease etc. Aspect difference is all not statistically significant, has comparability（P ＞ 0.05）.
Clinical manifestation
Patients with clinical manifestations is to have chronic cough, expectoration history, the uncomfortable in chest, respiratory failure such as dyspnea, drowsiness, staring spells Symptom, becomes apparent from after activity especially, barrel chest when increasing, and respiratory movement weakens, prolonged expiration, and vocal fremitus sound weakens or disappears Lose, percussion is in hyperresonant note, border of cardiac dullness reduces or disappears, and liver dullness circle declines, and heart sound is remote, diminished breath sound, and pulmonary has wet Rale, stringy and rolling pulse number.X-ray checks：Rabat shows that Pulmonary volume expands, and rib is parallel, and intercostal space is broadening, and the bright degree of lung increases, diaphragm Move down.Pulmonary function test：Forced expiratory volume accounts for forced vital capacity ratio ＜ 60% within 1st second, and maximal voluntary ventilation is less than predicted value 80%, residual volume accounts for the percentage ratio ＞ 40% of total lung capacity.
Therapeutic Method
Matched group：Stationary phase gives beclometasone 50 aerosol（" 50 " refer to often press the beclometasone containing 50 μ g） 3 times/d, 2 sprays/time, and oral aminophylline 0.2g, Levofloxacin 0.2g, 2 times/d.Other medicines are disabled during treatment.
Experimental group：Using the granule 1 of the embodiment of the present invention 1 preparation, using warm water dissolving, it is administered orally, each 10g, daily 3 Secondary.
Two groups of equal 7 days courses for the treatment of, continuously take 3 courses for the treatment of.
Criterion of therapeutical effect
The traditional Chinese medicine industry standard issued for 1994 with reference to State Administration of Traditional Chinese Medicine《Chinese medical disease Standardization of diagnosis and curative effect》 Work out criterion of therapeutical effect.Effective：Cough, cough up phlegm, dyspnea with rapid and short breath symptom is relieved, lab testing is obviously improved；Effectively：Cough, cough up Expectorant, dyspnea with rapid and short breath symptom mitigation, lab testing takes a turn for the better；Invalid：Cough, cough up phlegm, dyspnea with rapid and short breath symptom is no improved, lab testing is no good Turn.
Result
Two groups of comparitive study, are shown in Table 5.
5 liang of group comparitive study of table
Group Number of cases Effective Effectively Invalid Total effective rate (%)
Treatment group 83 52 22 9 89.2
Matched group 73 22 34 17 76.7
As can be seen from Table 5, imitated in terms for the treatment of chronic obstructive emphysema using the Chinese medicine composition of present invention preparation Fruit is more preferable than Western medicine.
All above-mentioned this intellectual properties of primary enforcement, do not set this new product of enforcement limiting other forms And/or new method.Those skilled in the art will be using this important information, and the above is changed, to realize similar execution feelings Condition.But, all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention is made with other forms, appoints What those skilled in the art possibly also with the disclosure above technology contents changed or be modified as equivalent variations etc. Effect embodiment.But every without departing from technical solution of the present invention content, according to the present invention technical spirit to above example institute Any simple modification, equivalent variations and the remodeling made, still falls within the protection domain of technical solution of the present invention.

Claims (9)

1. a kind of Chinese medicine composition for treating chronic obstructive emphysema it is characterised in that：Described Chinese medicine composition former Material medicine is only by Gecko, Semen Coiciss, Radix Pseudostellariae, Radix Glycyrrhizae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Semen Trigonellae, Caulis Spatholobi, Rhizoma Curcumae Longae, Fructus Hippophae, Radix seu Herba Gei aleppici, white Before, Fructus Forsythiae, Herba Inulae, Herba Ephedrae, Semen Myristicae, Cordyceps, Fructus Aristolochiae, Semen Euryaless, Thallus Laminariae (Thallus Eckloniae), Radix Curcumae, Pericarpium Citri Reticulatae, Resina Liquidambarises, Rhizoma Alpiniae Officinarum, Lignum Aquilariae Resinatum, the Rhizoma Anemarrhenae, Rhizoma Polygoni Cuspidati, Caulis Sargentodoxae are constituted；
In described Chinese medicine composition, the weight portion of each crude drug is respectively Gecko 60 weight portion～70 weight portion, Semen Coiciss 40 weight Part～50 weight portions, Radix Pseudostellariae 100 weight portion～110 weight portion, Radix Glycyrrhizae 35 weight portion～45 weight portion, Rhizoma Polygonati 70 weight portion～ 80 weight portions, Fructus Schisandrae Chinensis 50 weight portion～60 weight portion, Semen Trigonellae 25 weight portion～35 weight portion, Caulis Spatholobi 45 weight portion～55 Weight portion, Rhizoma Curcumae Longae 30 weight portion～40 weight portion, Fructus Hippophae 35 weight portion～45 weight portion, Radix seu Herba Gei aleppici 45 weight portion～55 weight Part, Rhizoma Cynanchi Stauntonii 25 weight portion～35 weight portion, Fructus Forsythiae 35 weight portion～45 weight portion, Herba Inulae 40 weight portion～50 weight portion, fiber crops Yellow 40 weight portion～50 weight portions, Semen Myristicae 25 weight portion～35 weight portion, Cordyceps 20 weight portion～30 weight portion, horse pocket Bell 30 weight portion～40 weight portion, Semen Euryaless 30 weight portion～40 weight portion, Thallus Laminariae (Thallus Eckloniae) 20 weight portion～30 weight portion, Radix Curcumae 15 weight Part～25 weight portions, Pericarpium Citri Reticulatae 30 weight portion～40 weight portion, Resina Liquidambarises 25 weight portion～35 weight portion, Rhizoma Alpiniae Officinarum 20 weight portion～ 30 weight portions, Lignum Aquilariae Resinatum 20 weight portion～30 weight portion, the Rhizoma Anemarrhenae 55 weight portion～65 weight portion, Rhizoma Polygoni Cuspidati 75 weight portion～85 weight Part, Caulis Sargentodoxae 30 weight portion～40 weight portion.
2. Chinese medicine composition as claimed in claim 1 it is characterised in that：The dosage form of described Chinese medicine composition is tablet, flexible glue Capsule, powder, granule, pill, mixture.
3. the Chinese medicine composition described in claim 1 preparation method it is characterised in that：When the dosage form of described Chinese medicine composition is Granule, specifically,
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixture, with Add the distillation water retting 2h～4h with respect to 6～8 times of mixture quality afterwards, pour in volatile oil extractor, the way of distillation is extracted Volatile oil 4～6h, obtains volatile oil extracting solution, and remaining Aqueous extracts filter, and adds with respect to 4～6 times of its quality in residue The ethanol of determining alcohol 70%～80%, heating and refluxing extraction 2～3 times, extract 2～4h every time, extracting solution merges, filters, and above Aqueous extracts after the filtration obtaining merge, and obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distilled water of these component raw material medicine gross weight meter 5～7 times amount, decoct Boil 2～4 hours, filtration, medicinal residues add the distilled water of these component raw material medicine gross weight meter 5～7 times amount, decoct 1～3 little When, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05～0.1Mpa, vacuum be -0.02～- Under conditions of 0.1Mpa, be concentrated into the clear paste that relative density at 60 DEG C is 1.1～1.3, let cool, side add determining alcohol be 70%～ 80% ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50%～60% (V/V), stands overnight, filtration, filtering residue Plus be 70%～80% ethanol with respect to the determining alcohol of 2～4 times of its quality, it is sufficiently stirred for, filtration, merges filtrate twice, and above The the first filtrate mixing obtaining, concentrating under reduced pressure removes solvent, obtains dry cream, is ground into powder, obtains dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6～8 times of its quality, being slowly added to first The volatile oil of step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4～1:5, and it is stirred continuously 1h～2h, after cold preservation 24h, Filter, be spray-dried, pulverize, obtain volatile oil embedded object；
4th step, dried cream powder and the mixing of volatile oil embedded object are subsequently added dextrin and sucrose, dry with respect to 100 weight portions Cream powder, the addition of dextrin is 100 weight portion～150 weight portions, and the addition of sucrose is 250 weight portion～350 weight portions, puts In wet granulator, mix 3～8 minutes, make granule, send in vacuum drier and be vacuum dried, temperature of charge is 40～70 DEG C, vacuum be -0.08Mpa～-0.12Mpa, charging rate be 15～20L/h, material strip transfer rate be 20～ 30cm/min, subpackage after being dried.
4. the Chinese medicine composition described in claim 1 preparation method it is characterised in that：When the dosage form of described Chinese medicine composition is Powder, specifically,
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixture, with Add the distillation water retting 2h～4h with respect to 6～8 times of mixture quality afterwards, pour in volatile oil extractor, the way of distillation is extracted Volatile oil 4～6h, obtains volatile oil extracting solution, and remaining Aqueous extracts filter, and adds with respect to 4～6 times of its quality in residue The ethanol of determining alcohol 70%～80%, heating and refluxing extraction 2～3 times, extract 2～4h every time, extracting solution merges, filters, and above Aqueous extracts after the filtration obtaining merge, and obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distilled water of these component raw material medicine gross weight meter 5～7 times amount, decoct Boil 2～4 hours, filtration, medicinal residues add the distilled water of these component raw material medicine gross weight meter 5～7 times amount, decoct 1～3 little When, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05～0.1Mpa, vacuum be -0.02～- Under conditions of 0.1Mpa, be concentrated into the clear paste that relative density at 60 DEG C is 1.1～1.3, let cool, side add determining alcohol be 70%～ 80% ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50%～60% (V/V), stands overnight, filtration, filtering residue Plus be 70%～80% ethanol with respect to the determining alcohol of 2～4 times of its quality, it is sufficiently stirred for, filtration, merges filtrate twice, and above The the first filtrate mixing obtaining, concentrating under reduced pressure removes solvent, obtains dry cream, be ground into dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6～8 times of its quality, being slowly added to first The volatile oil of step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4～1:5, and it is stirred continuously 1h～2h, after cold preservation 24h, Filter, be spray-dried, pulverize, obtain volatile oil embedded object；
The volatile oil embedded object mixing that 4th step, the dried cream powder that obtain second step and the 3rd step obtain, sends into vacuum drier In be vacuum dried, temperature of charge be 40～70 DEG C, vacuum be -0.08Mpa～-0.12Mpa, charging rate be 15～ 20L/h, material strip transfer rate is 20～30cm/min, sends into the powder being ground into 100 mesh～200 mesh in pulverizer, ultraviolet Antivirus, obtains powder.
5. the Chinese medicine composition described in claim 1 preparation method it is characterised in that：When the dosage form of described Chinese medicine composition is Capsule, specifically,
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixture, with Add the distillation water retting 2h～4h with respect to 6～8 times of mixture quality afterwards, pour in volatile oil extractor, the way of distillation is extracted Volatile oil 4～6h, obtains volatile oil extracting solution, and remaining Aqueous extracts filter, and adds with respect to 4～6 times of its quality in residue The ethanol of determining alcohol 70%～80%, heating and refluxing extraction 2～3 times, extract 2～4h every time, extracting solution merges, filters, and above Aqueous extracts after the filtration obtaining merge, and obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distilled water of these component raw material medicine gross weight meter 5～7 times amount, decoct Boil 2～4 hours, filtration, medicinal residues add the distilled water of these component raw material medicine gross weight meter 5～7 times amount, decoct 1～3 little When, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05～0.1Mpa, vacuum be -0.02～- Under conditions of 0.1Mpa, be concentrated into the clear paste that relative density at 60 DEG C is 1.1～1.3, let cool, side add determining alcohol be 70%～ 80% ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50%～60% (V/V), stands overnight, filtration, filtering residue Plus be 70%～80% ethanol with respect to the determining alcohol of 2～4 times of its quality, it is sufficiently stirred for, filtration, merges filtrate twice, and above The the first filtrate mixing obtaining, concentrating under reduced pressure removes solvent, obtains dry cream, is ground into powder, obtains dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6～8 times of its quality, being slowly added to first The volatile oil of step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4～1:5, and it is stirred continuously 1h～2h, after cold preservation 24h, Filter, pulverize, obtain volatile oil embedded object；
4th step, dried cream powder, volatile oil embedded object is mixed homogeneously with disperse medium vegetable oil, is placed in wet granulator, mixes To close 3～8 minutes, make granule, send in vacuum drier and be vacuum dried, temperature of charge is 40～70 DEG C, vacuum is- 0.08Mpa～-0.12Mpa, charging rate is 15～20L/h, and material strip transfer rate is 20～30cm/min, loads capsule, institute The mass ratio stating dried cream powder with described disperse medium is 1:1.5～2.5.
6. the Chinese medicine composition described in claim 1 is used for the application in the medicine treating chronic obstructive emphysema in preparation.
7. a kind of Chinese medicinal composition granules for treating chronic obstructive emphysema it is characterised in that：Described granule Crude drug only by Gecko, Semen Coiciss, Radix Pseudostellariae, Radix Glycyrrhizae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Semen Trigonellae, Caulis Spatholobi, Rhizoma Curcumae Longae, Fructus Hippophae, Radix seu Herba Gei aleppici, Rhizoma Cynanchi Stauntonii, Fructus Forsythiae, Herba Inulae, Herba Ephedrae, Semen Myristicae, Cordyceps, Fructus Aristolochiae, Semen Euryaless, Thallus Laminariae (Thallus Eckloniae), Radix Curcumae, Pericarpium Citri Reticulatae, Resina Liquidambarises, Gao Liang Rhizoma Zingiberis Recens, Lignum Aquilariae Resinatum, the Rhizoma Anemarrhenae, Rhizoma Polygoni Cuspidati, Caulis Sargentodoxae are constituted,
In described Chinese medicine composition, the weight portion of each crude drug is respectively Gecko 60 weight portion～70 weight portion, Semen Coiciss 40 weight Part～50 weight portions, Radix Pseudostellariae 100 weight portion～110 weight portion, Radix Glycyrrhizae 35 weight portion～45 weight portion, Rhizoma Polygonati 70 weight portion～ 80 weight portions, Fructus Schisandrae Chinensis 50 weight portion～60 weight portion, Semen Trigonellae 25 weight portion～35 weight portion, Caulis Spatholobi 45 weight portion～55 Weight portion, Rhizoma Curcumae Longae 30 weight portion～40 weight portion, Fructus Hippophae 35 weight portion～45 weight portion, Radix seu Herba Gei aleppici 45 weight portion～55 weight Part, Rhizoma Cynanchi Stauntonii 25 weight portion～35 weight portion, Fructus Forsythiae 35 weight portion～45 weight portion, Herba Inulae 40 weight portion～50 weight portion, fiber crops Yellow 40 weight portion～50 weight portions, Semen Myristicae 25 weight portion～35 weight portion, Cordyceps 20 weight portion～30 weight portion, horse pocket Bell 30 weight portion～40 weight portion, Semen Euryaless 30 weight portion～40 weight portion, Thallus Laminariae (Thallus Eckloniae) 20 weight portion～30 weight portion, Radix Curcumae 15 weight Part～25 weight portions, Pericarpium Citri Reticulatae 30 weight portion～40 weight portion, Resina Liquidambarises 25 weight portion～35 weight portion, Rhizoma Alpiniae Officinarum 20 weight portion～ 30 weight portions, Lignum Aquilariae Resinatum 20 weight portion～30 weight portion, the Rhizoma Anemarrhenae 55 weight portion～65 weight portion, Rhizoma Polygoni Cuspidati 75 weight portion～85 weight Part, Caulis Sargentodoxae 30 weight portion～40 weight portion；
The preparation method of described granule specifically,
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixture, with Add the distillation water retting 2h～4h with respect to 6～8 times of mixture quality afterwards, pour in volatile oil extractor, the way of distillation is extracted Volatile oil 4～6h, obtains volatile oil extracting solution, and remaining Aqueous extracts filter, and adds with respect to 4～6 times of its quality in residue The ethanol of determining alcohol 70%～80%, heating and refluxing extraction 2～3 times, extract 2～4h every time, extracting solution merges, filters, and above Aqueous extracts after the filtration obtaining merge, and obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distilled water of these component raw material medicine gross weight meter 5～7 times amount, decoct Boil 2～4 hours, filtration, medicinal residues add the distilled water of these component raw material medicine gross weight meter 5～7 times amount, decoct 1～3 little When, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05～0.1Mpa, vacuum be -0.02～- Under conditions of 0.1Mpa, be concentrated into the clear paste that relative density at 60 DEG C is 1.1～1.3, let cool, side add determining alcohol be 70%～ 80% ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50%～60% (V/V), stands overnight, filtration, filtering residue Plus be 70%～80% ethanol with respect to the determining alcohol of 2～4 times of its quality, it is sufficiently stirred for, filtration, merges filtrate twice, and above The the first filtrate mixing obtaining, concentrating under reduced pressure removes solvent, obtains dry cream, is ground into powder, obtains dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6～8 times of its quality, being slowly added to first The volatile oil of step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4～1:5, and it is stirred continuously 1h～2h, after cold preservation 24h, Filter, be spray-dried, pulverize, obtain volatile oil embedded object；
4th step, dried cream powder and the mixing of volatile oil embedded object are subsequently added dextrin and sucrose, dry with respect to 100 weight portions Cream powder, the addition of dextrin is 100 weight portion～150 weight portions, and the addition of sucrose is 250 weight portion～350 weight portions, puts In wet granulator, mix 3～8 minutes, make granule, send in vacuum drier and be vacuum dried, temperature of charge is 40～70 DEG C, vacuum be -0.08Mpa～-0.12Mpa, charging rate be 15～20L/h, material strip transfer rate be 20～ 30cm/min, subpackage after being dried.
8. a kind of Chinese medicine composition composition powders for treating chronic obstructive emphysema it is characterised in that：The raw material of described powder Medicine is only by Gecko, Semen Coiciss, Radix Pseudostellariae, Radix Glycyrrhizae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Semen Trigonellae, Caulis Spatholobi, Rhizoma Curcumae Longae, Fructus Hippophae, Radix seu Herba Gei aleppici, white Before, Fructus Forsythiae, Herba Inulae, Herba Ephedrae, Semen Myristicae, Cordyceps, Fructus Aristolochiae, Semen Euryaless, Thallus Laminariae (Thallus Eckloniae), Radix Curcumae, Pericarpium Citri Reticulatae, Resina Liquidambarises, Rhizoma Alpiniae Officinarum, Lignum Aquilariae Resinatum, the Rhizoma Anemarrhenae, Rhizoma Polygoni Cuspidati, Caulis Sargentodoxae are constituted,
In described Chinese medicine composition, the weight portion of each crude drug is respectively Gecko 60 weight portion～70 weight portion, Semen Coiciss 40 weight Part～50 weight portions, Radix Pseudostellariae 100 weight portion～110 weight portion, Radix Glycyrrhizae 35 weight portion～45 weight portion, Rhizoma Polygonati 70 weight portion～ 80 weight portions, Fructus Schisandrae Chinensis 50 weight portion～60 weight portion, Semen Trigonellae 25 weight portion～35 weight portion, Caulis Spatholobi 45 weight portion～55 Weight portion, Rhizoma Curcumae Longae 30 weight portion～40 weight portion, Fructus Hippophae 35 weight portion～45 weight portion, Radix seu Herba Gei aleppici 45 weight portion～55 weight Part, Rhizoma Cynanchi Stauntonii 25 weight portion～35 weight portion, Fructus Forsythiae 35 weight portion～45 weight portion, Herba Inulae 40 weight portion～50 weight portion, fiber crops Yellow 40 weight portion～50 weight portions, Semen Myristicae 25 weight portion～35 weight portion, Cordyceps 20 weight portion～30 weight portion, horse pocket Bell 30 weight portion～40 weight portion, Semen Euryaless 30 weight portion～40 weight portion, Thallus Laminariae (Thallus Eckloniae) 20 weight portion～30 weight portion, Radix Curcumae 15 weight Part～25 weight portions, Pericarpium Citri Reticulatae 30 weight portion～40 weight portion, Resina Liquidambarises 25 weight portion～35 weight portion, Rhizoma Alpiniae Officinarum 20 weight portion～ 30 weight portions, Lignum Aquilariae Resinatum 20 weight portion～30 weight portion, the Rhizoma Anemarrhenae 55 weight portion～65 weight portion, Rhizoma Polygoni Cuspidati 75 weight portion～85 weight Part, Caulis Sargentodoxae 30 weight portion～40 weight portion；
The preparation method of described powder specifically,
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixture, with Add the distillation water retting 2h～4h with respect to 6～8 times of mixture quality afterwards, pour in volatile oil extractor, the way of distillation is extracted Volatile oil 4～6h, obtains volatile oil extracting solution, and remaining Aqueous extracts filter, and adds with respect to 4～6 times of its quality in residue The ethanol of determining alcohol 70%～80%, heating and refluxing extraction 2～3 times, extract 2～4h every time, extracting solution merges, filters, and above Aqueous extracts after the filtration obtaining merge, and obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distilled water of these component raw material medicine gross weight meter 5～7 times amount, decoct Boil 2～4 hours, filtration, medicinal residues add the distilled water of these component raw material medicine gross weight meter 5～7 times amount, decoct 1～3 little When, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05～0.1Mpa, vacuum be -0.02～- Under conditions of 0.1Mpa, be concentrated into the clear paste that relative density at 60 DEG C is 1.1～1.3, let cool, side add determining alcohol be 70%～ 80% ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50%～60% (V/V), stands overnight, filtration, filtering residue Plus be 70%～80% ethanol with respect to the determining alcohol of 2～4 times of its quality, it is sufficiently stirred for, filtration, merges filtrate twice, and above The the first filtrate mixing obtaining, concentrating under reduced pressure removes solvent, obtains dry cream, be ground into dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6～8 times of its quality, being slowly added to first The volatile oil of step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4～1:5, and it is stirred continuously 1h～2h, after cold preservation 24h, Filter, be spray-dried, pulverize, obtain volatile oil embedded object；
The volatile oil embedded object mixing that 4th step, the dried cream powder that obtain second step and the 3rd step obtain, sends into vacuum drier In be vacuum dried, temperature of charge be 40～70 DEG C, vacuum be -0.08Mpa～-0.12Mpa, charging rate be 15～ 20L/h, material strip transfer rate is 20～30cm/min, sends into the powder being ground into 100 mesh～200 mesh in pulverizer, ultraviolet Antivirus, obtains powder.
9. a kind of Chinese medicinal composition capsules agent for treating chronic obstructive emphysema it is characterised in that：Described capsule Crude drug only by Gecko, Semen Coiciss, Radix Pseudostellariae, Radix Glycyrrhizae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Semen Trigonellae, Caulis Spatholobi, Rhizoma Curcumae Longae, Fructus Hippophae, Radix seu Herba Gei aleppici, Rhizoma Cynanchi Stauntonii, Fructus Forsythiae, Herba Inulae, Herba Ephedrae, Semen Myristicae, Cordyceps, Fructus Aristolochiae, Semen Euryaless, Thallus Laminariae (Thallus Eckloniae), Radix Curcumae, Pericarpium Citri Reticulatae, Resina Liquidambarises, Gao Liang Rhizoma Zingiberis Recens, Lignum Aquilariae Resinatum, the Rhizoma Anemarrhenae, Rhizoma Polygoni Cuspidati, Caulis Sargentodoxae are constituted,
In described Chinese medicine composition, the weight portion of each crude drug is respectively Gecko 60 weight portion～70 weight portion, Semen Coiciss 40 weight Part～50 weight portions, Radix Pseudostellariae 100 weight portion～110 weight portion, Radix Glycyrrhizae 35 weight portion～45 weight portion, Rhizoma Polygonati 70 weight portion～ 80 weight portions, Fructus Schisandrae Chinensis 50 weight portion～60 weight portion, Semen Trigonellae 25 weight portion～35 weight portion, Caulis Spatholobi 45 weight portion～55 Weight portion, Rhizoma Curcumae Longae 30 weight portion～40 weight portion, Fructus Hippophae 35 weight portion～45 weight portion, Radix seu Herba Gei aleppici 45 weight portion～55 weight Part, Rhizoma Cynanchi Stauntonii 25 weight portion～35 weight portion, Fructus Forsythiae 35 weight portion～45 weight portion, Herba Inulae 40 weight portion～50 weight portion, fiber crops Yellow 40 weight portion～50 weight portions, Semen Myristicae 25 weight portion～35 weight portion, Cordyceps 20 weight portion～30 weight portion, horse pocket Bell 30 weight portion～40 weight portion, Semen Euryaless 30 weight portion～40 weight portion, Thallus Laminariae (Thallus Eckloniae) 20 weight portion～30 weight portion, Radix Curcumae 15 weight Part～25 weight portions, Pericarpium Citri Reticulatae 30 weight portion～40 weight portion, Resina Liquidambarises 25 weight portion～35 weight portion, Rhizoma Alpiniae Officinarum 20 weight portion～ 30 weight portions, Lignum Aquilariae Resinatum 20 weight portion～30 weight portion, the Rhizoma Anemarrhenae 55 weight portion～65 weight portion, Rhizoma Polygoni Cuspidati 75 weight portion～85 weight Part, Caulis Sargentodoxae 30 weight portion～40 weight portion；
The preparation method of described capsule specifically,
The first step, Radix Pseudostellariae, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Radix seu Herba Gei aleppici, Cordyceps, Semen Euryaless are mixed in proportion, and obtain mixture, with Add the distillation water retting 2h～4h with respect to 6～8 times of mixture quality afterwards, pour in volatile oil extractor, the way of distillation is extracted Volatile oil 4～6h, obtains volatile oil extracting solution, and remaining Aqueous extracts filter, and adds with respect to 4～6 times of its quality in residue The ethanol of determining alcohol 70%～80%, heating and refluxing extraction 2～3 times, extract 2～4h every time, extracting solution merges, filters, and above Aqueous extracts after the filtration obtaining merge, and obtain the first filtrate；
Second step, remaining components are mixed in proportion, and add the distilled water of these component raw material medicine gross weight meter 5～7 times amount, decoct Boil 2～4 hours, filtration, medicinal residues add the distilled water of these component raw material medicine gross weight meter 5～7 times amount, decoct 1～3 little When, filtration, merging filtrate, thickening temperature be 60 DEG C, steam pressure be 0.05～0.1Mpa, vacuum be -0.02～- Under conditions of 0.1Mpa, be concentrated into the clear paste that relative density at 60 DEG C is 1.1～1.3, let cool, side add determining alcohol be 70%～ 80% ethanol side is stirred and accounted for overall solution volume to ethanol volumn concentration is 50%～60% (V/V), stands overnight, filtration, filtering residue Plus be 70%～80% ethanol with respect to the determining alcohol of 2～4 times of its quality, it is sufficiently stirred for, filtration, merges filtrate twice, and above The the first filtrate mixing obtaining, concentrating under reduced pressure removes solvent, obtains dry cream, is ground into powder, obtains dried cream powder；
3rd step, by beta-schardinger dextrin-with after complete with respect to the distilled water heating for dissolving of 6～8 times of its quality, being slowly added to first The volatile oil of step preparation, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:4～1:5, and it is stirred continuously 1h～2h, after cold preservation 24h, Filter, pulverize, obtain volatile oil embedded object；
4th step, dried cream powder, volatile oil embedded object is mixed homogeneously with disperse medium vegetable oil, is placed in wet granulator, mixes To close 3～8 minutes, make granule, send in vacuum drier and be vacuum dried, temperature of charge is 40～70 DEG C, vacuum is- 0.08Mpa～-0.12Mpa, charging rate is 15～20L/h, and material strip transfer rate is 20～30cm/min, loads capsule, institute The mass ratio stating dried cream powder with described disperse medium is 1:1.5～2.5.
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CN102526674A (en) * 2012-02-06 2012-07-04 孟庆云 Medicine for treating bronchitis and bronchial asthma suffered by children aging from three to seven
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