CN101537163A - Chinese traditional medicine composition for curing emphysema and preparation method thereof - Google Patents

Abstract

The invention relates to a Chinese traditional medicine composition for curing emphysema. The Chinese traditional medicine composition is prepared by ephedra, liquorice, gypsum gypsum, asarum, dried ginger, Fritillaria thunbergii, peach kernel, Chinese cinnamon, pinellia tuber, oriental paperbush flower, almond, schisandra fruit, white atractylodes rhizome, frosythia fruit and/or a pharmaceutically accepted carrier. The invention also relates to a preparation method of the Chinese traditional medicine composition. The Chinese traditional medicine composition has the effects of supplementing qi and relieving exterior syndrome, resolving sputum and relieving asthma, dispersing lung qi to activate yang and tonifying the lung to improve inspiration and is used for various symptoms such as cough, expectoration, dyspnea, and the like caused by the emphysema.

Description

Emophysematous Chinese medicine composition of a kind of treatment and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, specifically, relate to emophysematous Chinese medicine composition of a kind of treatment and preparation method thereof.

Background technology

Emphysema are meant the air flue elasticity attenuation, excessive expansion, inflation of terminal bronchiole far-end (alveolar bronchiole, alveolar duct, alveolar sac and alveolar) and the lung volume increases or simultaneously with the destructive pathological state of airway walls.By its pathogenic factor emphysema following several types is arranged: aging-lung emphysema, compensatory emphysema, interstitial emphysema, kitchen range emphysema, other property emphysema at interval, obstructive emphysema.

Emophysematous pathogenesis is not illustrated so far as yet fully, is commonly considered as that multiple factor synergism forms:

One, causes the long-term suction, allergy etc. of the various factors of chronic bronchitis such as infection, smoking, atmospheric pollution, occupational dust and harmful gas, all can cause obstructive emphysema.

Two, the unbalance theory of elastoser and inhibitive factor thereof.

During the concurrent emphysema of chronic bronchitis, the dyspnea that increases the weight of has gradually appearred on the basis of symptoms such as original cough, expectoration.At first only in work, upstairs or have when mountain-climbing, climbing out of breath; Along with the development of pathological changes, when the activity of level land, even when tranquillization, also feel out of breath.When the chronic bronchitis acute attack, bronchial secretion increases, and further increases the weight of the ventilatory function obstacle, and aggravation uncomfortable in chest, out of breath is arranged, and can occur the symptom of respiratory failure when serious, as cyanosis, headache, drowsiness, staring spells etc.

The self health care of emphysematic patients should be noted following several respects:

(1) protopathy to causing that this is sick as tracheitis, chronic bronchitis, bronchial asthma and pneumosilicosis etc., actively be prevented and treated.This is sick because the impaired lung function evil influences healthy and resistance, and both reciprocal causations, so, note at ordinary times taking good care of, promote healthy and resistance, be that what to improve pulmonary function is basic method, and will establish the confidence of healing, this disease is not an incurable disease.

(2), can actively participate in some suitable sports according to patient's muscle power.As to jog be a kind of most complete general coordination exercise, can increase vital capacity and endurance, keeps eupnea when jogging, and enough oxygen is entered in the body.Taijiquan, soft behaviour, walkings etc. can be promoted healthy, and all patients who takes regular exercise for many years move the person less and more can keep fit than manying rest.

(3) emphysematic patients is afraid of cold winter most, also very easy catching a cold, and sx after each respiratory tract infection, pulmonary function is also influenced, carries out cold resistant training and can improve patient's resistance.In spring, earlier with two hands friction head faces and upper and lower extremities expose portion, several minutes at every turn, little red in well to skin, be dipped at indoor towel and do the whole body friction, every day 1-2 time after wringing out in the cold water summer for several times every day.Use cold water after autumn instead and wipe face.Behind cold resistant training, can reduce and suffer from flu, respiratory tract infection like this.

(4) emphysematic patients must be lain up when pulmonary infection, abides by the positive antiinflammatory of doctor's advice, and spasmolytic is relievingd asthma, and takes medicine on time.In time, mends and can not act with undue haste, in principle based on eliminating evil.

(5) note nutrition, improve Abwehrkraft des Koepers.Select suitably that protein content is higher the food that enriches vitamin again for use, as milk product, eggs, gravy.Diet is suitable light usually, and is unsuitable over-salty, and will be at regular time and quantity.Eat vegetable and fruit more, eat seafood and so on less, as Penaeus seu panulirus, Channa argus, Trichiurus haumela etc.Also want the alleviating alcohol addiction smoking cessation.

The traditional Chinese medical science thinks that emphysema belong to the category of " cough ", " phlegm retention ".Chinese medicine thinks that heresy is dissolved in lung, and obstruction of lung-QI must not be declared smooth and superinverse, so cough; Phlegm-damp is tangible YIN pathogen, spleen deficiency generating phlegm, and accumulation of phlegm in the collaterals of the lung, air flue is unfavorable, so expectoration is more usually; The human functional activity of vital energy lifting, the burnt transhipment of mediating among the bad full spleen, the not semen deposition of modern spleen, the essence of water and grain cohesion is an expectorant, ascending the clear and descending the turbid is not normal, then becomes thin, and is weak, loses weight the epigastrium distending pain; The course of disease with the passing of time, insufficiency of primordial QI, heart arteries and veins retardance, or kidney-Yang desires to take off, very unit is outer looses, and causes the lung heart failure, thus see cyanosis, tachycardia, drowsiness, absentminded, even generation respiratory failure or mental and physical efforts table exhaust.

The traditional Chinese medical science is divided into four types with this disease:

(1) be secondary to the diseases caused by exogenous pathogenic factor ailment said due to cold or exposure: the procatarxis lung cold, feel ailment said due to cold or exposure symptom aggravation again, and see cough with dyspnea and breathe heavily, short of breath, wheezing sound in the throat is coughed and is told white foam expectorant.If when failing heat-transformation because of being affected by the cold, exterior symptoms must have nasal obstruction, thin nasal discharge, fever with aversion to cold and lossless, clear urine in large amounts, it is normal or rare soft to defecate, thin white fur of tongue, body of the tongue is light red, floating and tense pulse.If experience wind heat or be affected by the cold and heat-transformation person, disease is seen fever without chill, and antiperspirant is arranged, and goes out rough heat, and the nostril is crimson, the turbid thickness of tears, floating and rapid pulse, yellow fur, big dry stool, double see thirsty, agitation, or the meeting order edema of holding concurrently.Supplementing QI for expelling the pathogenic factors from the body surface is worked as in treatment.

(2) be secondary to the lung-heat cough with asthma: the lung-heat cough with asthma, both can consume impairing the lung liquid, also can undermine lung qi and cause the deficiency of vital energy and do not hold back, the stagnation of QI is in the interior pulmonary distension that forms, and disease sees that cough with dyspnea loses heart, and yellow urine is few, is convenient to knot greatly, and the red tongue tongue is white, slippery and rapid pulse.Treatment answers removing heat-phlegm to relieving asthma.

(3) asthenia of pulmonosplenic qi: lose heart usually, with cough, the rale dyspnea with rapid respiration, white and slippery fur, loose stool, rapid pulse is unable, heavy then dyspnea with rapid and short breath bluish lip, the pale tongue deficient and weak pulse is controlled and should be activated yang by lung qi dispersing.

(4) insufficiency of QI of the lung and kidney: little slight asthma of coughing, breathe air cooling and very brief unable, moving then cardiopalmus, the fear of cold spontaneous perspiration, pale complexion, extremities being not warm can doublely be seen the clear urine in large amounts or the enuresis, the stool aqueous-grainy diarrhea, pale tongue, tongue is white, deep-thready pulse, treatment employing tonifying the lung improving inspiration by invigorating kidney-QI.

Traditional Chinese medical science employing supplementing QI for expelling the pathogenic factors from the body surface, resolving phlegm and relieving asthma, lung qi dispersing activate yang, this disease of decoction for the treatment of tonifying the lung improving inspiration by invigorating kidney-QI.

Summary of the invention

The purpose of this invention is to provide the emophysematous Chinese medicine composition of a kind of treatment.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides the emophysematous Chinese medicine composition of a kind of treatment, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

Herba Ephedrae 5-10 part Radix Glycyrrhizae 15-20 part Gypsum Fibrosum 20-25 part

Herba Asari 10-15 part Rhizoma Zingiberis 10-15 part Bulbus Fritillariae Thunbergii 15-25 part

Semen Persicae 10-20 part Cortex Cinnamomi 5-10 part Rhizoma Pinelliae 15-25 part

Dream Flos Farfarae 10-15 part Semen Armeniacae Amarum 15-25 part Fructus Schisandrae Chinensis 10-15 part

Rhizoma Atractylodis Macrocephalae 5-10 part Fructus Forsythiae 10-15 part

Effective ingredient is preferably made by weight by following raw materials according:

23 parts of 18 parts of Gypsum Fibrosum of 8 portions of Radix Glycyrrhizaes of Herba Ephedrae

18 parts of 13 parts of Bulbus Fritillariae Thunbergii of 13 portions of Rhizoma Zingiberiss of Herba Asari

21 parts of 8 parts of Rhizoma Pinelliaes of 16 portions of Cortex Cinnamomis of Semen Persicae

13 parts of 21 parts of Fructus Schisandrae Chinensis of 13 parts of Semen Armeniacae Amarums of dream Flos Farfarae

13 parts of 8 parts of Fructus Forsythiaes of the Rhizoma Atractylodis Macrocephalae

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

(1) to be broken into impalpable powder standby for gypsum powder;

(2) Radix Glycyrrhizae, Semen Persicae, the Rhizoma Pinelliae are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Herba Ephedrae, Herba Asari, Rhizoma Zingiberis, Bulbus Fritillariae Thunbergii, Cortex Cinnamomi, dream Flos Farfarae, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Fructus Forsythiae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.

Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.

Chinese medicine composition of the present invention has that supplementing QI for expelling the pathogenic factors from the body surface, resolving phlegm and relieving asthma, lung qi dispersing activate yang, the effect of tonifying the lung improving inspiration by invigorating kidney-QI, is used for diseases such as cough that emphysema cause, expectoration, dyspnea.

The specific embodiment

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1: Chinese medicinal composition granules of the present invention

(1) to be ground into impalpable powder standby for Gypsum Fibrosum 230g;

(2) Radix Glycyrrhizae 180g, Semen Persicae 160g, Rhizoma Pinelliae 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Herba Ephedrae 80g, Herba Asari 130g, Rhizoma Zingiberis 130g, Bulbus Fritillariae Thunbergii 180g, Cortex Cinnamomi 80g, dream Flos Farfarae 130g, Semen Armeniacae Amarum 210g, Fructus Schisandrae Chinensis 130g, Rhizoma Atractylodis Macrocephalae 80g, Fructus Forsythiae 130g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, adds dextrin 1000g, lactose 800g, mixing, with 75% ethanol wet granulation promptly.

Embodiment 2: Chinese medicinal composition capsules agent of the present invention

(1) to be ground into impalpable powder standby for Gypsum Fibrosum 230g;

(2) Radix Glycyrrhizae 180g, Semen Persicae 160g, Rhizoma Pinelliae 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Herba Ephedrae 80g, Herba Asari 130g, Rhizoma Zingiberis 130g, Bulbus Fritillariae Thunbergii 180g, Cortex Cinnamomi 80g, dream Flos Farfarae 130g, Semen Armeniacae Amarum 210g, Fructus Schisandrae Chinensis 130g, Rhizoma Atractylodis Macrocephalae 80g, Fructus Forsythiae 130g decoct with water secondary, each 2 hours, filter merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, add dextrin 700g mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3: Chinese medicine composition tablet of the present invention

(1) to be ground into impalpable powder standby for Gypsum Fibrosum 230g;

(2) Radix Glycyrrhizae 180g, Semen Persicae 160g, Rhizoma Pinelliae 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Herba Ephedrae 80g, Herba Asari 130g, Rhizoma Zingiberis 130g, Bulbus Fritillariae Thunbergii 180g, Cortex Cinnamomi 80g, dream Flos Farfarae 130g, Semen Armeniacae Amarum 210g, Fructus Schisandrae Chinensis 130g, Rhizoma Atractylodis Macrocephalae 80g, Fructus Forsythiae 130g decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, add starch 300g, microcrystalline Cellulose 200g is with 70% ethanol wet granulation, and tabletting, coating are promptly.

Claims (4)

1, the emophysematous Chinese medicine composition of a kind of treatment is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:

Herba Ephedrae 5-10 part Radix Glycyrrhizae 15-20 part Gypsum Fibrosum 20-25 part

Herba Asari 10-15 part Rhizoma Zingiberis 10-15 part Bulbus Fritillariae Thunbergii 15-25 part

Semen Persicae 10-20 part Cortex Cinnamomi 5-10 part Rhizoma Pinelliae 15-25 part

Dream Flos Farfarae 10-15 part Semen Armeniacae Amarum 15-25 part Fructus Schisandrae Chinensis 10-15 part

Rhizoma Atractylodis Macrocephalae 5-10 part Fructus Forsythiae 10-15 part.

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:

23 parts of 18 parts of Gypsum Fibrosum of 8 portions of Radix Glycyrrhizaes of Herba Ephedrae

18 parts of 13 parts of Bulbus Fritillariae Thunbergii of 13 portions of Rhizoma Zingiberiss of Herba Asari

21 parts of 8 parts of Rhizoma Pinelliaes of 16 portions of Cortex Cinnamomis of Semen Persicae

13 parts of 21 parts of Fructus Schisandrae Chinensis of 13 parts of Semen Armeniacae Amarums of dream Flos Farfarae

13 parts of 8 parts of Fructus Forsythiaes of the Rhizoma Atractylodis Macrocephalae.

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) to be broken into impalpable powder standby for gypsum powder;

(2) Radix Glycyrrhizae, Semen Persicae, the Rhizoma Pinelliae are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Herba Ephedrae, Herba Asari, Rhizoma Zingiberis, Bulbus Fritillariae Thunbergii, Cortex Cinnamomi, dream Flos Farfarae, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Fructus Forsythiae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.