CN101543590A - Chinese medicinal composition for treating chronic pharyngitis and preparation method thereof - Google Patents

Abstract

The invention relates to a Chinese medicinal composition for treating chronic pharyngitis, which is prepared by honeysuckle flower, boat-fruited scaphium seed, radix scrophulariae, bulbus fritillariae cirrhosae, licorice roots northwest origin, straight ladybell root, balloon flower root, white sun-dried ginseng, dwarf lilyturf tuber, schisandra chinensis, noble dendrobium stem, fragrant solomonseal rhizome, lalang grass rhizome, bamboo shavings and/or pharmaceutically acceptable carriers. The invention also relates to a preparation method of the Chinese medicinal composition. The Chinese medicinal composition has the efficacies of nourishing yin to clear away the lung-heat, clearing heat and reducing phlegm, soothing throat and relieving sore throat, and is applied to the symptoms of throat discomfort, obstruction, swell, ardor, parching, itch, irritable cough, sore throat, and the like, caused by the chronic pharyngitis.

Description

A kind of Chinese medicine composition for the treatment of chronic pharyngitis and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of chronic pharyngitis and preparation method thereof.

Background technology

Chronic pharyngitis is a kind of commonly encountered diseases, for the pharyngeal pathological changes of the caused diffusivity of chronic infection, mainly is the pharyngeal mucosa inflammation.Be mainly in the adult, becoming impatient property pharyngitis, long-term dust or harmful gas stimulate its main diseases because of having repeatly, tobacco and wine excessively or other bad life habits, the stimulation of sinusitis secretions, allergic constitution or passive protective physical fitness attenuating etc.Chronic pharyngitis also can be the topical manifestations of some systemic disease, as anemia, diabetes, liver cirrhosis and chronic nephritis etc.

Chronic pharyngitis autodiagnosis main points: symptom is various, and pharyngeal discomfort has foreign body sensation, and the pharyngeal thing that has pharynx can not tell is again down always felt in the sense of expectorant viscous, stop up, swell, scorching hot, dry, itch, the irritative cough, little pharyngalgia etc. arranged.Often remove secretions with cough, when firmly pharyngeal secretions was eliminated in cough especially in the morning, symptom had of short duration alleviation.

Chronic pharyngitis sickness rate in the urbanite accounts for about 10% to 20% of laryngopharyngeal diseases.Because of its course of disease is long, the symptom stubbornness, the short-term difficulty is seen produce effects, so be difficult for curing.Its main diseases is because of roughly as follows:

1, acute pharyngitis shows effect repeatedly and fails thoroughly to cure and change into chronicly, long-term dust or harmful gas stimulate, tobacco and wine excessively or other bad life habits, the stimulation of sinusitis secretions, allergic constitution or passive protective physical fitness attenuating etc.

2, chronic pharyngitis also can be the topical manifestations of some systemic disease, as anemia, dyspepsia, long-term constipation of senile, heart disease, bronchitis, asthma, hepatic lesions, diabetes and chronic nephritis etc.

3, occupational factor.Mainly be mainly in the voice worker, as: teacher, performer etc.Because of long-term multilingual and sing, can stimulate pharyngeally, cause chronic congestion and cause a disease.

The prevention of chronic pharyngitis should note following some:

1, keep cleaning with the humid air in the room, indoor non-smoking is not placed on the article that penetrating odor is arranged indoor.Give birth to the family of stove heating, on stove, place a basin water, to improve dry environment.

2, reduce pharyngeal stimulation, smoking cessation, alleviating alcohol addiction avoids chemical gas to stimulate.The person answers active treatment the systemic disease.

3, avoid too much with sound, speech.Take a good rest, reduce and work hard, suitably take exercises.

4, few food is fried in shallow oil and is fried and food excitatory.The treatment of chronic pharyngitis can fully not recovered at short notice.Except that local and whole body therapeutic, adhere to before sleeping, reaching rinsing the mouth after meal with the light salt brine of temperature, the pharynx mucosa there is good maintenance effect.If not acute attack, do not abuse antibiosis anti-inflammatory drug, when necessity is taken, also should under physician guidance, use.

The traditional Chinese medical science thinks that chronic pharyngitis belongs to " hypopyretic laryngalgia " category.How by deficiency of YIN of both the lung and kidney, deficiency of body fluid, water thanks to can not, system fire and due to the hyperactivity of deficient fire.The bright Tianjin of asthenic fire is an expectorant, expectorant consor heat, and heat is more contained, and heal thanks in Tianjin, so the pharyngeal sense of discomfort of the clinical appearance of patient often has the actions that hawk such as " uttering a sound or a word ", " noise made in coughing or vomiting ".Even cause zest dry cough and nausea and vomiting.Meet irritations such as oil smoke, cold air, dust and increase the weight of, how with dry pharynx, hypodynia, itch or spirit tired, it is unable talk, dysphoria with feverish sensation in the chest palms and soles, soreness of the waist and knees, red tongue or do, tongue less, thready and rapid pulse etc.Employing traditional Chinese medical science Yin-nourishing and body fluid promoting is moisturized, the method treatment of relieving sore-throat by clearing away heat, often can obtain curative effect preferably.

The traditional Chinese medical science thinks that the cause of disease of chronic pharyngitis has exopathogenic factor and endogenous cause of ill two parts.Aspects such as outer because dust, foul smell stimulate, hobby tobacco and wine, pungent, absurd and work, endogenous cause of ill is a YIN-deficiency of the lung and kidney.Since YIN-fluid being insufficient, water failing to restrain blazing fire, hyperactivity of deficient fire, the smoked throat that burns causes chronic pharyngitis.The acute pharyngitis due to wind-heat mistake is controlled or treats not thorough, outbreak repeatedly, and deficiency of vital QI, cloudy liquid secretly consumes, the easier chronic pharyngitis that causes.

The traditional Chinese medical science reduces three types with primary disease:

One, the scorching type of deficiency of YIN fire: pharyngeal discomfort, the pain gesture is indistinct, and foreign body sensation is arranged, and sticking amount of expectoration is few, with afternoon dysphoria with smothery sensation, the lassitude loin and legs, red tongue, pulse condition is counted accurately.

Two, stagnation of phlegm blood stasis type: pharyngeal dry and astringent, pain is twinge, and the pharynx sarolemma is dark red, the normal discomfort of feeling sick because of hawking again and again.Red tongue, yellow and greasy fur, rolling and rapid pulse.

Three, the withered type in deficiency of YIN Tianjin: dry pharynx is very itched, scorching hot dry pain, and drinking-water back pain can be postponed, and foreign body sensation is obvious, dreaminess at night, tinnitus dim eyesight.Red tongue with lack of fluid, thready and rapid pulse.

The treatment doctor trained in Western medicine of chronic pharyngitis is generally paid attention to local application, and the Chinese traditional treatment primary disease focuses on and effects a permanent cure, and presses the medication of medicine typing method, and curative effect is better.

The traditional Chinese medical science adopts this disease of decoction for the treatment of nourishing YIN and clearing away lung-heat, removing heat-phlegm, the sore-throat relieving that wets one's whistle.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic pharyngitis.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of chronic pharyngitis, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

Flos Lonicerae 5-10 part Semen Sterculiae Lychnophorae 15-20 part Radix Scrophulariae 10-20 part

Bulbus Fritillariae Cirrhosae 20-30 part Radix Glycyrrhizae 20-25 part Radix Adenophorae (Radix Glehniae) 10-20 part

Radix Platycodonis 5-10 part Radix Ginseng 10-20 part 15-25 Radix Ophiopogonis part

Fructus Schisandrae Chinensis 10-15 part Herba Dendrobii 5-10 part Rhizoma Polygonati Odorati 15-25 part

Rhizoma Imperatae 15-25 part Caulis Bambusae In Taenia 20-30 part

Effective ingredient is preferably made by weight by following raw materials according:

16 parts of 18 portions of Radix Scrophulariae of 8 parts of Semen Sterculiae Lychnophoraes of Flos Lonicerae

16 parts of 23 parts of Radix Adenophorae (Radix Glehniae) of 25 parts of Radix Glycyrrhizae of Bulbus Fritillariae Cirrhosae

21 parts of 8 parts of Radix Ginsengs of Radix Platycodonis 15 parts of Radix Ophiopogonis

21 parts of 8 portions of Rhizoma Polygonati Odorati of 13 parts of Herba Dendrobiis of Fructus Schisandrae Chinensis

26 parts of 22 parts of Caulis Bambusae In Taenia of Rhizoma Imperatae

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

(1) Radix Platycodonis, Radix Scrophulariae, Bulbus Fritillariae Cirrhosae, Fructus Schisandrae Chinensis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(2) Flos Lonicerae, Semen Sterculiae Lychnophorae, Radix Glycyrrhizae, Radix Adenophorae (Radix Glehniae), Radix Ginseng, Radix Ophiopogonis, Herba Dendrobii, Rhizoma Polygonati Odorati, Rhizoma Imperatae, Caulis Bambusae In Taenia decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned clear paste, drying, be ground into fine powder, make granule, capsule and oral liquid with pharmaceutically acceptable carrier.

Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by oral administrations such as granule, capsule, oral liquids is used.

Chinese medicine composition of the present invention has nourishing YIN and clearing away lung-heat, removing heat-phlegm, the effect of the sore-throat relieving that wets one's whistle, and is used for the pharyngeal discomfort that chronic pharyngitis causes, stop up, swell, scorching hot, dry, itch, the irritative cough, little diseases such as pharyngalgia arranged.

The specific embodiment

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1: Chinese medicinal composition granules of the present invention

(1) Radix Platycodonis 80g, Radix Scrophulariae 160g, Bulbus Fritillariae Cirrhosae 250g, Fructus Schisandrae Chinensis 130g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(2) Flos Lonicerae 80g, Semen Sterculiae Lychnophorae 180g, Radix Glycyrrhizae 230g, Radix Adenophorae (Radix Glehniae) 160g, Radix Ginseng 150g, Radix Ophiopogonis, 210g, Herba Dendrobii 80g, Rhizoma Polygonati Odorati 210g, Rhizoma Imperatae 220g, Caulis Bambusae In Taenia 260g decocted with water secondary, each 2 hours, filtered, merging filtrate, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned clear paste, drying is ground into fine powder, adds dextrin 1000g, lactose 800g, mixing, with 75% ethanol wet granulation promptly.

Embodiment 2: Chinese medicinal composition capsules agent of the present invention

(1) Radix Platycodonis 80g, Radix Scrophulariae 160g, Bulbus Fritillariae Cirrhosae 250g, Fructus Schisandrae Chinensis 130g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(2) Flos Lonicerae 80g, Semen Sterculiae Lychnophorae 180g, Radix Glycyrrhizae 230g, Radix Adenophorae (Radix Glehniae) 160g, Radix Ginseng 150g, Radix Ophiopogonis, 210g, Herba Dendrobii 80g, Rhizoma Polygonati Odorati 210g, Rhizoma Imperatae 220g, Caulis Bambusae In Taenia 260g decocted with water secondary, each 2 hours, filter merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned clear paste, dry, be ground into fine powder, add dextrin 700g mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3: Chinese medicine composition oral liquid of the present invention

(1) Radix Platycodonis 80g, Radix Scrophulariae 160g, Bulbus Fritillariae Cirrhosae 250g, Fructus Schisandrae Chinensis 130g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and merging filtrate, concentrating under reduced pressure become 1/3rd of original volume;

(2) Flos Lonicerae 80g, Semen Sterculiae Lychnophorae 180g, Radix Glycyrrhizae 230g, Radix Adenophorae (Radix Glehniae) 160g, Radix Ginseng 150g, Radix Ophiopogonis, 210g, Herba Dendrobii 80g, Rhizoma Polygonati Odorati 210g, Rhizoma Imperatae 220g, Caulis Bambusae In Taenia 260g decocted with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, concentrating under reduced pressure becomes 1/3rd of original volume.Two kinds of solution merge, and add glucose 100g and Nipagin ester 5g, stir, and ultrafiltration, fill are promptly.

Claims (4)

1, a kind of Chinese medicine composition for the treatment of chronic pharyngitis is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:

Flos Lonicerae 5-10 part Semen Sterculiae Lychnophorae 15-20 part Radix Scrophulariae 10-20 part

Bulbus Fritillariae Cirrhosae 20-30 part Radix Glycyrrhizae 20-25 part Radix Adenophorae (Radix Glehniae) 10-20 part

Radix Platycodonis 5-10 part Radix Ginseng 10-20 part 15-25 Radix Ophiopogonis part

Fructus Schisandrae Chinensis 10-15 part Herba Dendrobii 5-10 part Rhizoma Polygonati Odorati 15-25 part

Rhizoma Imperatae 15-25 part Caulis Bambusae In Taenia 20-30 part

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:

16 parts of 18 portions of Radix Scrophulariae of 8 parts of Semen Sterculiae Lychnophoraes of Flos Lonicerae

16 parts of 23 parts of Radix Adenophorae (Radix Glehniae) of 25 parts of Radix Glycyrrhizae of Bulbus Fritillariae Cirrhosae

21 parts of 8 parts of Radix Ginsengs of Radix Platycodonis 15 parts of Radix Ophiopogonis

21 parts of 8 portions of Rhizoma Polygonati Odorati of 13 parts of Herba Dendrobiis of Fructus Schisandrae Chinensis

26 parts of 22 parts of Caulis Bambusae In Taenia of Rhizoma Imperatae

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and oral liquid as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) Radix Platycodonis, Radix Scrophulariae, Bulbus Fritillariae Cirrhosae, Fructus Schisandrae Chinensis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(2) Flos Lonicerae, Semen Sterculiae Lychnophorae, Radix Glycyrrhizae, Radix Adenophorae (Radix Glehniae), Radix Ginseng, Radix Ophiopogonis, Herba Dendrobii, Rhizoma Polygonati Odorati, Rhizoma Imperatae, Caulis Bambusae In Taenia decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned clear paste, drying, be ground into fine powder, make granule, capsule and oral liquid with pharmaceutically acceptable carrier.