CN101524518A - Chinese medicinal composition for treating asthma and preparation method thereof - Google Patents
Chinese medicinal composition for treating asthma and preparation method thereof Download PDFInfo
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- CN101524518A CN101524518A CN 200810101422 CN200810101422A CN101524518A CN 101524518 A CN101524518 A CN 101524518A CN 200810101422 CN200810101422 CN 200810101422 CN 200810101422 A CN200810101422 A CN 200810101422A CN 101524518 A CN101524518 A CN 101524518A
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Abstract
The invention relates to a Chinese medicinal composition for treating asthma, which is prepared by Chinese ephedra, tuber pinellia, asarum, liquorice, shizandra berry, gypsum, baikal skullcap root, earthworm, dried orange peel, bulbus fritillariae cirrhosae, aconite, astragalus root, radix cynanchi, salvia miltiorrhiza, ginger, caulis perllae, jujube kernel, radix aconiti feri, coltsfoot and/or a pharmaceutically acceptable carrier. The invention also relates to a method for preparing the Chinese medicinal composition. The Chinese medicinal composition has efficacies of clearing heat and freeing lung, and resolving phlegm and relieving asthma, and is used for diseases such as asthma caused by coexistence of phlegm and heat as well as lung qi obstruction.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of asthma and preparation method thereof.
Background technology
Bronchial asthma (bronchial asthma, be called for short asthma) is by the various kinds of cell chronic airway inflammation that participates in of mastocyte, eosinophilic granulocyte and T lymphocyte particularly; This kind inflammation can cause repeatedly symptoms such as the panting of outbreak, tachypnea, uncomfortable in chest and/or cough in the susceptible person, how to take place at night or morning; This type of symptom is often limited with extensive and changeable exhalation flow rate, but natural remission or alleviate through treatment partly; This kind symptom also increases multiple stimulating factor reactivity with air flue.External bronchial asthma prevalence, mortality rate rises gradually, and about 100,000,000 people of whole world bronchial asthma person become the main chronic disease of serious threat health of people.The asthma prevalence of China is 1%, and the child reaches 3%.
Consider that from narrow sense the definition of asthma should be: body is because factors such as external or intrinsic anaphylactogen or non-anaphylactogen cause the reversible spasm of air flue by neuro humor.The paroxysmal that shows as clinically time and again repeatedly is uncomfortable in chest, companion's wheezing sound and based on the dyspnea of expiration or have cough person concurrently.
The clinical manifestation of studying asthma then from broad sense by many in various degree pathophysiological change and the syndrome that forms, for example: bronchial muscular spasm, the air flue myxedema, mucous secretion increases, the mucomembranous cilium dysfunction, the bronchial mucosa plumpness, bronchorrhea thromboembolism or the like, can cause clinically in various degree asthma syndrome according to various pathophysiological change degree differences, weight person shows as acute serious status asthmaticus, the lighter only shows as uncomfortable in chest, some then shows as based on cough, and general common so-called bronchial asthma then often refers to the definition of narrow sense.
Often can see men and women, old and young in the life and all can suffer from asthma, though the performance of breathing heavily is similar, the asthma reason is diversified.Common asthma has following several:
Bronchial asthma is that a kind of anaphylactic disease majority is fallen ill when young or young, and at spring and autumn or meet outbreak when cold.It is very fast to make a return journey during asthma attack, and is characteristics with the expiration difficulty; Asthma stops the back as the normal person.But as outbreak repeatedly, can not alleviate, can develop into emphysema, pulmonary heart disease.
Asthmatic bronchitis, patient is except that the symptom that chronic bronchitis is arranged: long-term cough, the expectoration; Also with significantly panting, and how when respiratory tract infection, to increase the weight of.Usually in morbidity cold season, with middle-aged and elderly people number in the majority.This disease often develops into emphysema, pulmonary heart disease late period if control is bad.
Be lung bronchogenic carcinoma in addition, when carcinoma stops up big bronchus, also can cause and pant.Patient exhales, all feel difficulty when air-breathing.More than several asthma all be that the disease of bronchus or pulmonary causes, be called pulmonary asthma.
Also having a class asthma is that heart disease causes, claims cardiac asthma.Patient has coronary heart disease usually, rheumatic heart disease, and left heart failure appears in cardiomyopathy or hypertension, causes pulmonary's blood stasis, gas interchange disturbance, and asthma takes place.How this night-time attack of being everlasting of panting is at fast asleep afterwards 1, the 2 hour unexpected dyspnea that takes place.Patient wakes up with a start suddenly because of suffocated breathing uncomfortable in chest, is forced to sit up and breathes, coughs, coughs up pink frothy sputum.After most patients sat up, panting just alleviated, and this process is nocturnal paroxysmal dyspnea.
In addition, also have a kind of occupational asthma, asthma is relevant with some occupation in other words, and some chemistry of contact or metallic compound cause asthma in for example working.Their main feature is: contact with certain predetermined substance or in some specific environment, can cause this onste, in case disengage, symptom has just disappeared.
The traditional Chinese medical science thinks that asthma belongs to " heavy breathing ", " breathing heavily ", " phlegm retention " sick category.It is sound for ring breath in the larynx to roar, and breathes heavily to be tachypnea and dyspnea, and the two has concurrently and is called asthma.The main diseases of primary disease can not fallen ill at ordinary times because of being volt in the phlegm retention, meets certain factor and causes phlegm retention to be fought with in air flue to fall ill.The paathogenic factor more complicated, all affection of exogenous wind-cold summer-heat fails in time to show to loose, and heresy hinders in lung, and gas is cloth Tianjin not, and poly-liquid becomes expectorant.The salty delicious food of diet acid, raw and cold raw meat is greasy and cause dysfunction of the spleen in transportation, interior wine phlegm-damp, on do in lung, stop up the resistance lung qi.Plain report weak, or body void after being ill, as childhood measles, pertussis and repeated cold, having coughed for a long time, excess of YIN due to YANG-insufficiency, failure of qi transforming fluid is given birth in the phlegm retention.Or the deficiency of YIN excess of YANG, it is poly-that heat is steamed liquid, and the expectorant hot glue is solid.This shows that the main pathological factor that causes primary disease is an expectorant, so-called " asthma is specially main in expectorant ", diseases caused by exogenous pathogenic factor, diet, imbalance after being ill, feelings will internal injury, fatigue etc. all are risk factors.
The etiology and pathogenesis that causes asthma nothing more than following some: 1. diseases caused by exogenous pathogenic factor six evil, wind and cold bundle table, wind heat is stopped up lung, it is smooth and be asthma all to cause lung qi.The diseases caused by exogenous pathogenic factor six climate exopathogens comprise wind, cold, summer-heat, wet, dry, fiery, and the main diseases that wherein causes asthma is because of to tremble with fear.2. internal injury caused by excess of seven emotions, so-called seven emotions are promptly liked, anger, melancholy, think of, compassion, probably, frightened.Incoordination of seven emotions causes the visceral-qi discord, and lung qi must not be declared logical and is disease.3. improper diet and overtiredness, surfeit is pungent, and insobriety all can cause and breathe heavily.4. excess of sexual intercourse, suffering from a deficiency of the kidney can not improving inspiration by invigorating kidney-QI and cause and breathe heavily.5. the heart, kidney disease all can cause and breathe heavily.6. lose blood, gas is capable with blood, and blood loses and then consumes gas, breathes heavily so also can cause.
The traditional Chinese medical science is thought: lung is the device of storage expectorant, the spleen being the source of producing phlegm, and one of major function of kidney is an improving inspiration by invigorating kidney-QI.So the functional disorder of lung, spleen, kidney is the closest with being related of asthma.During treatment, also be function based on conditioning lung, spleen, kidney.For the treatment of asthma, the traditional Chinese medical science is wanted determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, but no matter is acupuncture or treatment by Chinese herbs, total principle be when not showing effect to set upright, promptly reinforcement is main; During outbreak, to attack heresy, promptly catharsis is main.
The traditional Chinese medical science adopts this disease of decoction for the treatment of reducing heat and dispersing lung-QI, expectorant and asthma-curing.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of asthma.
The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.
In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of asthma, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:
Herba Ephedrae 100-200 part Rhizoma Pinelliae 50-100 part Herba Asari 50-150 part
Radix Glycyrrhizae 100-200 part Fructus Schisandrae Chinensis 150-300 part Gypsum Fibrosum 200-400 part
Radix Scutellariae 100-150 part Pheretima 50-100 part Pericarpium Citri Reticulatae 200-300 part
Bulbus Fritillariae Cirrhosae 100-200 part Radix Aconiti Lateralis Preparata 150-200 part Radix Astragali 150-250 part
Rhizoma Cynanchi Stauntonii 100-150 part Radix Salviae Miltiorrhizae 50-100 part Rhizoma Zingiberis Recens 150-250 part
Caulis Perillae 200-300 part Semen Ziziphi Spinosae 50-150 part Radix Aconiti Kusnezoffii 100-150 part
Flos Farfarae 100-150 part
Effective ingredient is preferably made by weight by following raw materials according:
110 parts of 80 parts of Herba Asaris of 160 parts of Rhizoma Pinelliaes of Herba Ephedrae
330 parts of 220 parts of Gypsum Fibrosum of 160 parts of Fructus Schisandrae Chinensis of Radix Glycyrrhizae
260 parts of 80 parts of Pericarpium Citri Reticulataes of 130 parts of Pheretimas of Radix Scutellariae
220 parts of 180 parts of Radixs Astragali of 160 parts of Radix Aconiti Lateralis Preparatas of Bulbus Fritillariae Cirrhosae
220 parts in 80 portions of Rhizoma Zingiberis Recenss of 130 parts of Radix Salviae Miltiorrhizaes of Rhizoma Cynanchi Stauntonii
130 parts of 110 portions of Radix Aconiti Kusnezoffii of 260 parts of Semen Ziziphi Spinosaes of Caulis Perillae
130 parts of Flos Farfaraes
The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:
(1) Gypsum Fibrosum, Rhizoma Zingiberis Recens powder are broken into impalpable powder, and be standby;
(2) Radix Glycyrrhizae, Fructus Schisandrae Chinensis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Herba Ephedrae, the Rhizoma Pinelliae, Herba Asari, Radix Scutellariae, Pheretima, Pericarpium Citri Reticulatae, Bulbus Fritillariae Cirrhosae, Radix Aconiti Lateralis Preparata, the Radix Astragali, Rhizoma Cynanchi Stauntonii, Radix Salviae Miltiorrhizae, Caulis Perillae, Semen Ziziphi Spinosae, Radix Aconiti Kusnezoffii, Flos Farfarae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule, tablet pill with pharmaceutically acceptable carrier.
Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.
Chinese medicine composition of the present invention has the effect of reducing heat and dispersing lung-QI, expectorant and asthma-curing, is used for the diseases such as asthma that combination of phlegm and heat, inhibited pulmonary QI cause.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: Chinese medicinal composition granules of the present invention
(1) Gypsum Fibrosum 330g, Rhizoma Zingiberis Recens 220g are ground into impalpable powder, and be standby;
(2) Radix Glycyrrhizae 160g, Fructus Schisandrae Chinensis 220g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Herba Ephedrae 160g, Rhizoma Pinelliae 80g, Herba Asari 110g, Radix Scutellariae 130g, Pheretima 80g, Pericarpium Citri Reticulatae 260g, Bulbus Fritillariae Cirrhosae 160g, Radix Aconiti Lateralis Preparata 180g, Radix Astragali 220g, Rhizoma Cynanchi Stauntonii 130g, Radix Salviae Miltiorrhizae 80g, Caulis Perillae 260g, Semen Ziziphi Spinosae 110g, Radix Aconiti Kusnezoffii 130g, Flos Farfarae 130g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, adds dextrin 800g, lactose 400g, mixing, with 80% ethanol wet granulation promptly.
Embodiment: 2 Chinese medicinal composition capsules agent of the present invention
(1) Gypsum Fibrosum 330g, Rhizoma Zingiberis Recens 220g are ground into impalpable powder, and be standby;
(2) Radix Glycyrrhizae 160g, Fructus Schisandrae Chinensis 220g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Herba Ephedrae 160g, Rhizoma Pinelliae 80g, Herba Asari 110g, Radix Scutellariae 130g, Pheretima 80g, Pericarpium Citri Reticulatae 260g, Bulbus Fritillariae Cirrhosae 160g, Radix Aconiti Lateralis Preparata 180g, Radix Astragali 220g, Rhizoma Cynanchi Stauntonii 130g, Radix Salviae Miltiorrhizae 80g, Caulis Perillae 260g, Semen Ziziphi Spinosae 110g, Radix Aconiti Kusnezoffii 130g, Flos Farfarae 130g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, dry, be ground into fine powder, add dextrin 400g mixing, in the capsulae vacuus of packing into promptly.
Embodiment 3: Chinese medicine composition tablet of the present invention
(1) Gypsum Fibrosum 330g, Rhizoma Zingiberis Recens 220g are ground into impalpable powder, and be standby;
(2) Radix Glycyrrhizae 160g, Fructus Schisandrae Chinensis 220g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Herba Ephedrae 160g, Rhizoma Pinelliae 80g, Herba Asari 110g, Radix Scutellariae 130g, Pheretima 80g, Pericarpium Citri Reticulatae 260g, Bulbus Fritillariae Cirrhosae 160g, Radix Aconiti Lateralis Preparata 180g, Radix Astragali 220g, Rhizoma Cynanchi Stauntonii 130g, Radix Salviae Miltiorrhizae 80g, Caulis Perillae 260g, Semen Ziziphi Spinosae 110g, Radix Aconiti Kusnezoffii 130g, Flos Farfarae 130g decocts with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, add starch 300g, microcrystalline Cellulose 100g and carboxymethylstach sodium 100g are with 80% ethanol wet granulation, tabletting, the bag film-coat promptly.
Embodiment 4: Chinese medicine composition pill of the present invention
(1) Gypsum Fibrosum 330g, Rhizoma Zingiberis Recens 220g are ground into impalpable powder, and be standby;
(2) Radix Glycyrrhizae 160g, Fructus Schisandrae Chinensis 220g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Herba Ephedrae 160g, Rhizoma Pinelliae 80g, Herba Asari 110g, Radix Scutellariae 130g, Pheretima 80g, Pericarpium Citri Reticulatae 260g, Bulbus Fritillariae Cirrhosae 160g, Radix Aconiti Lateralis Preparata 180g, Radix Astragali 220g, Rhizoma Cynanchi Stauntonii 130g, Radix Salviae Miltiorrhizae 80g, Caulis Perillae 260g, Semen Ziziphi Spinosae 110g, Radix Aconiti Kusnezoffii 130g, Flos Farfarae 130g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, adds refined honey 50g and an amount of water, general ball is drying to obtain.
Claims (4)
1, a kind of Chinese medicine composition for the treatment of asthma is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:
Herba Ephedrae 100-200 part Rhizoma Pinelliae 50-100 part Herba Asari 50-150 part
Radix Glycyrrhizae 100-200 part Fructus Schisandrae Chinensis 150-300 part Gypsum Fibrosum 200-400 part
Radix Scutellariae 100-150 part Pheretima 50-100 part Pericarpium Citri Reticulatae 200-300 part
Bulbus Fritillariae Cirrhosae 100-200 part Radix Aconiti Lateralis Preparata 150-200 part Radix Astragali 150-250 part
Rhizoma Cynanchi Stauntonii 100-150 part Radix Salviae Miltiorrhizae 50-100 part Rhizoma Zingiberis Recens 150-250 part
Caulis Perillae 200-300 part Semen Ziziphi Spinosae 50-150 part Radix Aconiti Kusnezoffii 100-150 part
Flos Farfarae 100-150 part.
2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:
110 parts of 80 parts of Herba Asaris of 160 parts of Rhizoma Pinelliaes of Herba Ephedrae
330 parts of 220 parts of Gypsum Fibrosum of 160 parts of Fructus Schisandrae Chinensis of Radix Glycyrrhizae
260 parts of 80 parts of Pericarpium Citri Reticulataes of 130 parts of Pheretimas of Radix Scutellariae
220 parts of 180 parts of Radixs Astragali of 160 parts of Radix Aconiti Lateralis Preparatas of Bulbus Fritillariae Cirrhosae
220 parts in 80 portions of Rhizoma Zingiberis Recenss of 130 parts of Radix Salviae Miltiorrhizaes of Rhizoma Cynanchi Stauntonii
130 parts of 110 portions of Radix Aconiti Kusnezoffii of 260 parts of Semen Ziziphi Spinosaes of Caulis Perillae
130 parts of Flos Farfaraes.
3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.
4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:
(1) Gypsum Fibrosum, Rhizoma Zingiberis Recens powder are broken into impalpable powder, and be standby;
(2) Radix Glycyrrhizae, Fructus Schisandrae Chinensis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Herba Ephedrae, the Rhizoma Pinelliae, Herba Asari, Radix Scutellariae, Pheretima, Pericarpium Citri Reticulatae, Bulbus Fritillariae Cirrhosae, Radix Aconiti Lateralis Preparata, the Radix Astragali, Rhizoma Cynanchi Stauntonii, Radix Salviae Miltiorrhizae, Caulis Perillae, Semen Ziziphi Spinosae, Radix Aconiti Kusnezoffii, Flos Farfarae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule, tablet and pill with pharmaceutically acceptable carrier.
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| CN 200810101422 CN101524518A (en) | 2008-03-06 | 2008-03-06 | Chinese medicinal composition for treating asthma and preparation method thereof |
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| CN 200810101422 CN101524518A (en) | 2008-03-06 | 2008-03-06 | Chinese medicinal composition for treating asthma and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526394A (en) * | 2012-02-02 | 2012-07-04 | 南京中医药大学 | External use medicine for preventing and treating infantile asthma as well as acupoint application and preparation method thereof |
| CN102641350A (en) * | 2011-02-16 | 2012-08-22 | 辽宁中医药大学附属第二医院 | Lung-warming panting-calming granule and preparation process thereof |
-
2008
- 2008-03-06 CN CN 200810101422 patent/CN101524518A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641350A (en) * | 2011-02-16 | 2012-08-22 | 辽宁中医药大学附属第二医院 | Lung-warming panting-calming granule and preparation process thereof |
| CN102526394A (en) * | 2012-02-02 | 2012-07-04 | 南京中医药大学 | External use medicine for preventing and treating infantile asthma as well as acupoint application and preparation method thereof |
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Open date: 20090909 |