CN1465380A - Chinese medicine composition for treating asthma and preparation method thereof - Google Patents
Chinese medicine composition for treating asthma and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a Chinese medicine composition for curing asthma radically. Said medicine is made of 40 Chinese medicinal materials of Sichuan fritillaria bulb, Zhejiang fritillaria bulb, tussilago flower, stemona root, aster root, licorice and others as raw material according to a certain mixing ratio through a certain preparation process.
Description
Technical field:
The present invention relates to Chinese medicine composition, in particular a kind of Chinese medicine composition for the treatment of asthma and preparation method thereof.
Background technology:
Acute and chronic, asthmatic bronchitis and all kinds of asthma are a kind of frequently-occurring disease, commonly encountered diseases.Its clinical four big symptom shows as and coughs, breathes heavily, expectorant, inflammation.Medical circle is spreading saying of " interior not controlling being breathed heavily ", and asthma is considered as obstinate disease.
Asthma is refractory why, mainly is that medical history is long, outbreak repeatedly, thus cause the resistance of human body to descend, immunologic hypofunction, various pathogenic bacterium and anaphylactogen are invaded human body in an opponent's defence, stimulate respiratory tract, cause bronchial muscular spasm, the mucous hyperemia edema, secretions increase, respiratory tract is obstructed.If fundamentally treatment, just will leave over down the future trouble-obstinate asthma that is difficult to cure, serious emphysema, the core pulmonale of causing easily.
At present, people treat asthma medicine commonly used aminophylline sheet, Mai Sailaiyin sheet, lung heat clearing treating pill made of 18 kinds of Chinese medicine material, the powerful Zhichuan of aminophylline sheet, instant effect, but this product has the function that replaces corticoid, so take for a long time, is easy to generate dependency, and cause the atrophy of patient's adrenal cortex function apraxia easily, finally make the long-term dependence of needs of patients come assisted respiartion with continuity life; The Mai Sailaiyin sheet can be eliminated bronchitis fast, contain the medicine of removing the smooth muscle spasm effect, breathe happy purpose thereby reach very soon after the patient is taken medicine, do not finish by bronchus merely but breathe, it also needs " improving inspiration by invigorating kidney-QI " of lung " expiration " and kidney to finish jointly, so, as making the bronchial smooth muscle spasmolytic merely, can only before dissipating, the property of medicine solve dyspneic problem, but can not be from the treatment of going of disease itself, " apicifixed anther " that this just it has often been said also is easy to generate dependency; The lung heat clearing treating pill made of 18 kinds of Chinese medicine material is a pure Chinese medicinal preparation, can remove the lung endotoxin rapidly, and lung heat clearing fire, the dry effect of lung moistening are arranged, but the source of disease of cough with asthma is not merely at lung, as only starting with from lung merely, and do not consider other internal organs, then do not reach desired therapeutic effect-radical cure asthma.
Summary of the invention:
The purpose of this invention is to provide a kind of is that the base therapy principle is also helped the Chinese medicine composition with the treatment asthma of improving inspiration by invigorating the kidney, the spleen strengthening and damp drying with removing heat from the lung and dissipating phlegm, relieving cough and asthma.
Another object of the present invention provides a kind of preparation method of above-mentioned Chinese medicine composition.
Solution of the present invention is based on the theory of Chinese medical science of " breathing heavily at lung; its root is at kidney; it is at spleen ", i.e. " kidney loses improving inspiration by invigorating kidney-QI; moving then pant ", " the spleen being the source of producing phlegm ", " the lung being the utensil for storing phlegm ", the comprehensive treatment of taking strengthening vital QI to eliminate pathogenic factors, improving inspiration by invigorating the kidney, the spleen strengthening and damp drying, clearing heat in the lung guarantor lung, relieving cough and resolving phlegm, opening lung-energy, spasmolytic to relieving asthma, thus reach the purpose of effecting a radical cure asthma.
Chinese medicine composition of the present invention is made by following component: (consumption is a weight portion)
Bulbus Fritillariae Cirrhosae 3-7 Bulbus Fritillariae Thunbergii 3-7 Flos Farfarae 3-6 Radix Stemonae 5-8 Radix Asteris 5-8
Radix Glycyrrhizae 3-6 Semen Armeniacae Amarum 3-6 processs Rhizoma Pinelliae 3-6 Rhizoma Belamcandae 3-6 Chinese 3-6
Radix Scutellariae 3-6 Pericarpium Trichosanthis 3-6 Pheretima 5-8 Lignum Aquilariae Resinatum 3-6 Arisaema Cum Bile 3-6
Fructus Aurantii 3-7 Fructus Perillae 3-7 Radix Panacis Quinquefolii 5-8 Radix Pseudostellariae 5-8 Radix Codonopsis 5-8
Rhizoma Atractylodis Macrocephalae 5-8 Radix Morindae Officinalis 3-7 Cordyceps 5-8 Gecko 8-12 Placenta Hominis 8-12
Fructus Lycii 3-7 Radix Asparagi 2-5 Radix Ophiopogonis 2-5 Rhizoma Cynanchi Stauntonii 3-7 Radix Peucedani 2-5
Cortex Lycii 3-6 Fructus Toosendan 2-5 Cortex Mori 3-7 Bulbus Lilii 5-8 Radix Platycodonis 3-6
Semen Plantaginis 3-6 Radix Et Caulis Acanthopanacis Senticosi 5-8 Radix Astragali Preparata 3-7 Semen Lepidii (Semen Descurainiae) 3-7 Pericarpium Citri Reticulatae 3-7
The preferred weight of Chinese medicine composition of the present invention (part) proportioning is:
Bulbus Fritillariae Cirrhosae 6 Bulbus Fritillariae Thunbergii 6 Flos Farfaraees 6 Radixs Stemonae 7 Radix Asteriss 7
Radix Glycyrrhizae 6 Semen Armeniacae Amarums 6 are processed the Rhizoma Pinelliae 6 Rhizoma Belamcandae 6 Chineses 6
Radix Scutellariae 6 Pericarpium Trichosanthiss 6 Pheretimas 7 Lignum Aquilariae Resinatum 6 Arisaema Cum Bile 6
Fructus Aurantii 6 Fructus Perillaes 6 Radix Panacis Quinquefoliis 7 Radix Pseudostellariaes 7 Radix Codonopsis 7
The Rhizoma Atractylodis Macrocephalae 7 Radix Morindae Officinaliss 6 Cordycepss 7 Geckos 10 Placenta Hominiss 10
Fructus Lycii 6 Radix Asparagi 4 Radix Ophiopogonis 4 Rhizoma Cynanchi Stauntoniis 6 Radix Peucedanis 4
Cortex Lycii 6 Fructus Toosendans 4 Cortex Mori 6 Bulbus Liliies 6 Radix Platycodoniss 4
Semen Plantaginis 5 Radix Et Caulis Acanthopanacis Senticosis 6 Radix Astragali Preparatas 5 Semen Lepidii (Semen Descurainiae)s 6 Pericarpium Citri Reticulataes 6
The production method that above-mentioned each component is made Chinese medicine composition of the present invention is:
1. withdraw the money Flos Farfarae, Cordyceps, Radix Et Caulis Acanthopanacis Senticosi, after 40-48 hour,, collect percolate just with the Diluted Alcohol dipping with the slowly diafiltration of speed of per minute 1-3ml, device is preserved in addition, continue diafiltration to percolate near till colourless, collect continuous percolate, be concentrated into the thick paste shape below 60 ℃, adding just, percolate mixes, add the Diluted Alcohol dilution, static a couple of days, filter standby;
2. Chinese is soaked after 1-2 hour with vinegar and steam, dry after the steaming, with high heat earlier, treat to use slow fire instead, vinegar after " circle gas ": Chinese=20: 3 during steaming;
3. get the clean Rhizoma Pinelliae and be dipped to the interior no dried heart with clear water, take out, other adds Radix Glycyrrhizae, lime liquor soaks, and keeps pH value more than 12, and mouth is tasted little numb feeling in the tongue that has, and the tangent plane yellow evenly is degree, takes out, and is clean, the clean Rhizoma Pinelliae: Radix Glycyrrhizae: quicklime=20: 3: 2;
4. get and process the Rhizoma Arisaematis powder and add bile and mix thoroughly, steams 1 hour extremely transparent, taking-up cools, and makes fritter, drying; Or get the Rhizoma Arisaematis powder and add clean bile and mix thoroughly, put warm place, ferment after 7-15 days, continue again to steam or stewing out of water, to being black extractum shape, mouth is tasted and is not had the fiber crops flavor and be degree;
5. refined honey is diluted with cold boiled water, mix thoroughly, treat that mulse exhausts, put to fry in the heat pot when Radix Codonopsis is golden yellow, not too sticking hands and take out, cool Radix Codonopsis: refined honey=4: 1 with Radix Codonopsis;
6. pot is burnt heat, be sprinkled into Testa Tritici, drop into Rhizoma Atractylodis Macrocephalae sheet when waiting to smolder, constantly stir, burn and be yellowish-brown to the Rhizoma Atractylodis Macrocephalae and take out, sieve removes Testa Tritici, cools the Rhizoma Atractylodis Macrocephalae: Testa Tritici=10: 1;
7. the Radix Stemonae is cut sheet, fry to tack-free the Radix Stemonae: refined honey=8: 1 with refined honey;
8. Radix Scutellariae, the easy processed with honey of Radix Glycyrrhizae, the same Radix Stemonae of method for making;
9. Semen Armeniacae Amarum: incite skin;
10. after other residual components being mixed, be crushed to 120 order fine powders jointly, standby after 100-110 ℃ of following degerming;
11. select tilia pollen honey for use, the honey temperature is mixed well above-mentioned whole powder and sweet the mixing at 60-80 ℃, make the suitable ball bar of thickness, honey is 1 with the ratio of medicated powder: 1-1.5, at last with rubbing the ball plate with the hands or rolling the ball machine and make honeyed pill, pack the pill of the asthma that can obtain medical treatment, 10 gram/balls with paraffin paper.
This medicine can incapsulate medicated powder, 10 gram/grains.
Medicine of the present invention is inventor's a secret prescription handed down in the family from generation to generation, and Bulbus Lilii, Radix Astragali Preparata, Placenta Hominis, Chinese, Radix Codonopsis, Radix Et Caulis Acanthopanacis Senticosi, Radix Platycodonis are principal agent in the side, Bulbus Lilii nourishing the lung to arrest cough, clearing away heart-fire for tranquillization; The Radix Astragali Preparata tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance; Placenta Hominis is mended smart supporing yang, and nourishing blood and invigorating qi has the effect that strengthens the human body resistance; The Chinese antiallergic; Radix Codonopsis is controlled deficiency of QI in middle-JIAO, can strengthen the phagocytic function of reticuloendothelial system, improves the human body resistance against diseases; The Radix Et Caulis Acanthopanacis Senticosi air making-up and spleen enlivening, the kidney warming is calmed the nerves, the effect of similar Radix Ginseng sample tonify deficiency is arranged, control insufficiency of the spleen lack of appetite, indigestion and loss of appetite abdominal distention, myasthenia of limbs, asthenia is tired out, controls the soreness of the waist and knees of spleen kidney yang QI-insufficiency, lassitude, inappetence, insomnia and dreamful sleep has been taken body-building for a long time, the effect of inspiring enthusiasm, control the weak or body void after being ill of plain body, can be beneficial spiritual, defying age, the immunologic hypofunction that too much causes for adrenal gland's glucocorticoid has better curative effect, and tool antiviral, antitumaous effect and immunomodulating and promotion function, strengthen the nonspecific resistance of human body, and the pathological change that human body exists is hyperfunction or lowly all can makes it recover normal also can excitation be arranged to interrenal system various destructive stimuluses; Radix Platycodonis can make the respiratory mucosa secretory volume significantly increase, and action intensity can be compared with amine-oxides.Its comprehensive therapeutic effect is invigorating the spleen and regulating the stomach, helps kidney improving inspiration by invigorating kidney-QI, depressed lung-energy dispersing, preventing phlegm from forming and stopping coughing etc.
Medicine of the present invention and the contrast of aminophylline sheet in zoopery:
Annotate in the white mouse body that has infected bronchial asthma virus the injection of aminophylline is quiet, dissect through anesthesia, visible smooth muscle has halfhour spasmolysis, but the property of medicine will be recovered spasticity later at once, and after the anesthetis property of medicine, vomiting and hysterical performance can appear in white mouse; The decoction of this product is poured in the white mouse body that has infected bronchial asthma virus, dissect with anesthesia, as seen bronchial smooth muscle has tangible spasmolytic phenomenon, and the property of medicine is held time longer, and after repetition test continuous irrigation soup 2-3 time, the effect of long term inhibition smooth muscle spasm is arranged, and after the anesthetis property of medicine, white mouse there is no any abnormal response; Two white mouse of injecting aminophylline injection respectively and irritate feeding this product 5 times are placed in the chests of various pathogenic bacterium 20 minutes, the infection state of checking two white mouse shows: take in the white mouse body of this product and there is no any pathogenic bacteria, and have the pathogenic bacteria more than three kinds such as pneumobacillus to exist in the white mouse body of injection aminophylline, and through dissecting the obvious spasm of bronchial smooth muscle.
Above-mentioned experimental results show that: this product not only has in time, significantly alleviates and inhibitory action asthma, bronchitic clinical symptoms, and the function that good raising body immunity is arranged, and without any side effects, and with the aminophylline sheet be representative to treat this type of sick medicine quite different in the past.
Pharmacodynamics test shows: the mouse cough that ammonia is caused has tangible antitussive action, irritated contraction of guinea-pig isolated trachea and whole animal allergic asthma all there is tangible mitigation, Cavia porcellus passivity skin allergy, histamine's dermoreaction there is inhibitory action, white mouse and rabbit lung perfusion are had significant bronchorelaxing activity, anesthetized dog is had boosting significantly rapidly.
For showing the therapeutic effect of the present invention to asthma, the present invention looks into through the clinical sight of 500 routine systems, and cure rate reaches 96.7%, and total effective rate reaches 99.2%.
Instructions of taking: pill: each 1 ball, day clothes 2 times, half an hour, warm water took after meal; Capsule: each 80 grams, day clothes 2 times, half an hour, warm water took after meal; The child reduces by half, the taboo of taking medicine: food such as pungent, cold, living.
The specific embodiment:
Take by weighing raw material (gram) by following proportioning:
Bulbus Fritillariae Cirrhosae 20 Bulbus Fritillariae Thunbergii 20 Flos Farfaraees 18 Radixs Stemonae 25 Radix Asteriss 25
Radix Glycyrrhizae 18 Semen Armeniacae Amarums 18 are processed the Rhizoma Pinelliae 18 Rhizoma Belamcandae 18 Chineses 18
Radix Scutellariae 18 Pericarpium Trichosanthiss 18 Pheretimas 25 Lignum Aquilariae Resinatum 18 Arisaema Cum Bile 18
Fructus Aurantii 20 Fructus Perillaes 20 Radix Panacis Quinquefoliis 25 Radix Pseudostellariaes 25 Radix Codonopsis 25
The Rhizoma Atractylodis Macrocephalae 25 halberd meat 20 Cordycepss 25 Geckos 25 Placenta Hominiss 35
Fructus Lycii 20 Radix Asparagi 12 Radix Ophiopogonis 12 Rhizoma Cynanchi Stauntoniis 20 Radix Peucedanis 12
Cortex Lycii 18 Fructus Toosendans 12 Cortex Mori 20 Bulbus Liliies 25 Radix Platycodoniss 18
Semen Plantaginis 18 Radix Et Caulis Acanthopanacis Senticosis 25 Radix Astragali Preparatas 20 Semen Lepidii (Semen Descurainiae)s 20 Pericarpium Citri Reticulataes 20
Production method is as follows:
Withdraw the money Flos Farfarae, Cordyceps, Radix Et Caulis Acanthopanacis Senticosi, after 48 hours,, collect percolate just with 70% alcohol dipping with the slowly diafiltration of speed of per minute 1-3ml, device is preserved in addition, continue diafiltration to percolate near till colourless, collect continuous percolate, be concentrated into the thick paste shape below 60 ℃, adding just, percolate mixes, add 70% ethanol dilution, static a couple of days, filter standby; Chinese soaked after 1.5 hours with vinegar steam, dry after the steaming, with high heat earlier, treat to use slow fire instead, vinegar after " circle gas ": Chinese=20: 3 during steaming; Get the clean Rhizoma Pinelliae and be dipped to the interior no dried heart with clear water, take out, other adds Radix Glycyrrhizae, lime liquor soaks, and keeps pH value more than 12, and mouth is tasted little numb feeling in the tongue that has, and the tangent plane yellow evenly is degree, takes out, and is clean, the clean Rhizoma Pinelliae: Radix Glycyrrhizae: quicklime=20: 3: 2; Get and process the Rhizoma Arisaematis powder and add bile and mix thoroughly, steams 1 hour extremely transparent, taking-up cools, and makes fritter, drying; Or get the Rhizoma Arisaematis powder and add clean bile and mix thoroughly, put warm place, ferment after 15 days, continue again to steam or stewing out of water, to being black extractum shape, mouth is tasted and is not had the fiber crops flavor and be degree; Refined honey is diluted with cold boiled water, mix thoroughly, treat that mulse exhausts, put to fry in the heat pot when Radix Codonopsis is golden yellow, not too sticking hands and take out, cool Radix Codonopsis: refined honey=4: 1 with Radix Codonopsis; Pot is burnt heat, be sprinkled into Testa Tritici, drop into Rhizoma Atractylodis Macrocephalae sheet when waiting to smolder, constantly stir, burn and be yellowish-brown to the Rhizoma Atractylodis Macrocephalae and take out, sieve removes Testa Tritici, cools the Rhizoma Atractylodis Macrocephalae: Testa Tritici=10: 1; The Radix Stemonae is cut sheet, fry to tack-free the Radix Stemonae: refined honey=8: 1 with refined honey; Radix Scutellariae, the easy processed with honey of Radix Glycyrrhizae, the same Radix Stemonae of method for making; Semen Armeniacae Amarum is incited skin; After the residual components mixing, be crushed to 120 order fine powders jointly, standby after 110 ℃ of following degerming; Select tilia pollen honey for use, the honey temperature is mixed well above-mentioned whole powder and sweet the mixing at 80 ℃, makes the suitable ball bar of thickness, and honey is 1: 1.5 with the ratio of medicated powder, with rubbing the ball plate with the hands or rolling the ball machine and make honeyed pill, packs 10 gram/balls with paraffin paper at last.
Claims (4)
1, a kind of Chinese medicine composition for the treatment of asthma is characterized in that: it is the medicament of being made by the following weight proportion raw material
Bulbus Fritillariae Cirrhosae 3-7 Bulbus Fritillariae Thunbergii 3-7 Flos Farfarae 3-6 Radix Stemonae 5-8 Radix Asteris 5-8
Radix Glycyrrhizae 3-6 Semen Armeniacae Amarum 3-6 processs Rhizoma Pinelliae 3-6 Rhizoma Belamcandae 3-6 Chinese 3-6
Radix Scutellariae 3-6 Pericarpium Trichosanthis 3-6 Pheretima 5-8 Lignum Aquilariae Resinatum 3-6 Arisaema Cum Bile 3-6
Fructus Aurantii 3-7 Fructus Perillae 3-7 Radix Panacis Quinquefolii 5-8 Radix Pseudostellariae 5-8 Radix Codonopsis 5-8
Rhizoma Atractylodis Macrocephalae 5-8 Radix Morindae Officinalis 3-7 Cordyceps 5-8 Gecko 8-12 Placenta Hominis 8-12
Fructus Lycii 3-7 Radix Asparagi 2-5 Radix Ophiopogonis 2-5 Rhizoma Cynanchi Stauntonii 3-7 Radix Peucedani 2-5
Cortex Lycii 3-6 Fructus Toosendan 2-5 Cortex Mori 3-7 Bulbus Lilii 5-8 Radix Platycodonis 3-6
Semen Plantaginis 3-6 Radix Et Caulis Acanthopanacis Senticosi 5-8 Radix Astragali Preparata 3-7 Semen Lepidii (Semen Descurainiae) 3-7 Pericarpium Citri Reticulatae 3-7
2, the Chinese medicine composition of treatment asthma according to claim 1 is characterized in that: the weight proportion of each raw material is
Bulbus Fritillariae Cirrhosae 6 Bulbus Fritillariae Thunbergii 6 Flos Farfaraees 6 Radixs Stemonae 7 Radix Asteriss 7
Radix Glycyrrhizae 6 Semen Armeniacae Amarums 6 are processed the Rhizoma Pinelliae 6 Rhizoma Belamcandae 6 Chineses 6
Radix Scutellariae 6 Pericarpium Trichosanthiss 6 Pheretimas 7 Lignum Aquilariae Resinatum 6 Arisaema Cum Bile 6
Fructus Aurantii 6 Fructus Perillaes 6 Radix Panacis Quinquefoliis 7 Radix Pseudostellariaes 7 Radix Codonopsis 7
The Rhizoma Atractylodis Macrocephalae 7 Radix Morindae Officinaliss 6 Cordycepss 7 Geckos 10 Placenta Hominiss 10
Fructus Lycii 6 Radix Asparagi 4 Radix Ophiopogonis 4 Rhizoma Cynanchi Stauntoniis 6 Radix Peucedanis 4
Cortex Lycii 6 Fructus Toosendans 4 Cortex Mori 6 Bulbus Liliies 6 Radix Platycodoniss 4
Semen Plantaginis 5 Radix Et Caulis Acanthopanacis Senticosis 6 Radix Astragali Preparatas 5 Semen Lepidii (Semen Descurainiae)s 6 Pericarpium Citri Reticulataes 6
3, the Chinese medicine composition of treatment asthma according to claim 1 and 2 is characterized in that: the dosage form of this medicine is pill or capsule.
4, the preparation method of the Chinese medicine composition of treatment asthma according to claim 3 is characterized in that: the Flos Farfarae of withdrawing the money, Cordyceps, Radix Et Caulis Acanthopanacis Senticosi, behind Diluted Alcohol dipping 40-48 hour, slowly diafiltration of speed with per minute 1-3ml, collect percolate just, device is preserved in addition, continue diafiltration to percolate near till colourless, collect continuous percolate, be concentrated into the thick paste shape below 60 ℃, adding percolate mixing just, adding the Diluted Alcohol dilution, static a couple of days, filter standby; Chinese soaked after 1-2 hour with vinegar steam, dry after the steaming, with high heat earlier, treat to use slow fire instead, vinegar after " circle gas ": Chinese=20: 3 during steaming; Get the clean Rhizoma Pinelliae and be dipped to the interior no dried heart with clear water, take out, other adds Radix Glycyrrhizae, lime liquor soaks, and keeps pH value more than 12, and mouth is tasted little numb feeling in the tongue that has, and the tangent plane yellow evenly is degree, takes out, and is clean, the clean Rhizoma Pinelliae: Radix Glycyrrhizae: quicklime=20: 3: 2; Get and process the Rhizoma Arisaematis powder and add bile and mix thoroughly, steams 1 hour extremely transparent, taking-up cools, and makes fritter, drying; Or get the Rhizoma Arisaematis powder and add clean bile and mix thoroughly, put warm place, ferment after 7-15 days, continue again to steam or stewing out of water, to being black extractum shape, mouth is tasted and is not had the fiber crops flavor and be degree; Refined honey is diluted with cold boiled water, mix thoroughly, treat that mulse exhausts, put to fry in the heat pot when Radix Codonopsis is golden yellow, not too sticking hands and take out, cool Radix Codonopsis: refined honey=4: 1 with Radix Codonopsis; Pot is burnt heat, be sprinkled into Testa Tritici, drop into Rhizoma Atractylodis Macrocephalae sheet when waiting to smolder, constantly stir, burn and be yellowish-brown to the Rhizoma Atractylodis Macrocephalae and take out, sieve removes Testa Tritici, cools the Rhizoma Atractylodis Macrocephalae: Testa Tritici=10: 1; The Radix Stemonae is cut sheet, fry to tack-free the Radix Stemonae: refined honey=8: 1 with refined honey; Radix Scutellariae, the easy processed with honey of Radix Glycyrrhizae, the same Radix Stemonae of method for making; Semen Armeniacae Amarum is incited skin; After other residual components mixing, be crushed to 120 order fine powders jointly, standby after 100-110 ℃ of following degerming; Select tilia pollen honey for use, the honey temperature is mixed well above-mentioned whole powder and sweet the mixing at 60-80 ℃, make the suitable ball bar of thickness, honey is 1 with the ratio of medicated powder: 1-1.5, at last with rubbing the ball plate with the hands or rolling the ball machine and make honeyed pill, pack the pill of the asthma that can obtain medical treatment with paraffin paper.
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