CN102578703B - Alcoholic extract paste of common coltsfoot flower and preparation method and application thereof - Google Patents
Alcoholic extract paste of common coltsfoot flower and preparation method and application thereof Download PDFInfo
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- CN102578703B CN102578703B CN201210038413.XA CN201210038413A CN102578703B CN 102578703 B CN102578703 B CN 102578703B CN 201210038413 A CN201210038413 A CN 201210038413A CN 102578703 B CN102578703 B CN 102578703B
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- alcoholic extract
- extract paste
- coltsfoot flower
- common coltsfoot
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Abstract
The invention discloses alcoholic extract paste of common coltsfoot flower, a preparation method of the alcoholic extract paste of common coltsfoot flower and application of the alcoholic extract paste of common coltsfoot flower to cigarettes. The method comprises the following steps: after carrying out coarse grinding on common coltsfoot flower, extracting by ethanol, filtering, distilling and concentrating to prepare the alcoholic extract paste product of common coltsfoot flower. When the alcoholic extract paste of common coltsfoot flower is diluted to have the concentration of 1 to 5 percent by ethanol with the concentration of 95 percent and the diluted alcoholic extract paste of common coltsfoot flower is added into tobacco shreds according to 0.015 percent to 0.05 percent of the weight of the tobacco shreds, the cigarette flavor is enriched, the stimulation and miscellaneous gas are reduced, the alcoholic extract paste of common coltsfoot flower is beneficial for improving the aftertaste of the cigarettes and the cigarettes have mellow flavor and excellent aftertaste. The cigarettes prepared by the alcoholic extract paste of common coltsfoot flower can take effects of moistening lung, reducing phlegm, relieving a cough and relieving asthma in the smoking process of a patient who suffers from dyspnea and cough and cannot give up smoking. The quality of the cigarettes can be obviously improved. The alcoholic extract paste of common coltsfoot flower has high practical value.
Description
Technical field
The invention belongs to cigarette additive preparing technical field, be specifically related to a kind of alcoholic extract paste of common coltsfoot flower.Also relate to a kind of described preparation method of alcoholic extract paste of common coltsfoot flower and the application in cigarette thereof simultaneously.
Background technology
Tobacco is one of Important Economic crop of China, and cigarette is prevailing more than 200 year in the whole world, can until 20th century, and the mankind just start to recognize the harm of tobacco to the mankind.Smoking is the major incentive of the NCDs such as cardiovascular and cerebrovascular disease, cancer and pulmonary emphysema, and smoker is the communicable disease such as easy infection tuberculosis and pneumonia more.Point out according to " Chinese Control smoking in 2011 report ", China becomes the maximum tobacco leaf production state in the whole world and maximum tobacco consumption state with 300,000,000 smokers, and China has more than 100 ten thousand people to die from the disease relevant to tobacco every year.But due to the hobby of smoker and the dependence of nicotine, numerous smokers is made to be difficult to again smoking cessation, can add some and can remove the benefit materials coughed and breathe heavily and reduce and poison in cigarette, to reduce the murder by poisoning of tobacco to smoker, be the developing direction that cigarette industry is selected.
Useful medicinal herb components is applied in the middle of production of cigarettes, serve useful remarkable result, as ZL96117493.5 " a kind of herbal health care type cigarette " can reduce the content of the harmful substance in smog, there is tonifying kidney and strengthening yang, reduce phlegm, cough-relieving, relieving asthma, strengthen and regulate the effect such as human immunologic function.ZL200610054656.7 adopts multiple medium-height grass the effective elements of the medicine to be join in cigarette filter after middle boiling fraction 95% ethanol dilutes, and have obvious cough-relieving, eliminate the phlegm, relieving asthma, anti-inflammatory etc. alleviates flue gas to the dysgenic effect of respiratory system.
Tussilago is classified as treatment by traditional Chinese medicine and breathes heavily the key medicine of coughing, and its effect is generally acknowledged with effect.It is obvious that effect is breathed heavily in its cough-relieving of application in cigarette, as all adopted tussilago medicinal material in above-mentioned two patents.Patent ZL200710017853.6 then adopts to be mixed with essence by tussilago volatile oil to add in pipe tobacco and rolls into a kind of Chinese style and fall burnt cigarette with reduced toxicity, can prevent or alleviate the spread effect of smoke from cigarette to respiratory mucosa, the tar in smoke from cigarette and nicotine content can be reduced simultaneously, play and fall burnt attenuation, play moistening lung, reduce phlegm, the effect of cough-relieving.
Tussilago is the dry flower of feverfew coltsfoot Tussilago farfara L..Its medicinal part is its bud part, the validity of its medicinal material is not only the volatile oil part that it contains, better effect that wherein a lot of active ingredient embodies tussilago is very important, active ingredient in tussilago is fully extracted application, could more effectively play antibechic, eliminate the phlegm and antiasthmatic effect.Containing alkaloid in the spending of tussilago: tussilago alkali (tussilagine), renardine (senkirkine); Sesquiterpene Polyesters: Tussilagonone (tussilagone) is also known as farfaratin (tussilagin, 14-acetoxy-7 β-(3-ethylcrotonoyloxy) notonipetranone), methylbutanoic acid farfaratin fat (14-acetoxy-7 β-(3-ethyl-cis-crotonoyloxy)-1 α-(2-methylbutyryloxy) notonipetranone), deacetylate farfaratin (7 β-(3-ethyl-cis-crotonoyloxy)-14-hydroxy-notonipetranone), 7 β-go (3-ethyl crotonic oil acyloxy)-7 β-Radix Angelicae Sinensis acyloxy farfaratin (14-acetoxy-7 β-angeloyloxy-notonipetranone), 7 β-go (3-ethyl crotonic oil acyloxy)-7 β-climbing groundsel acyloxy farfaratin (14-acetoxy-7 β-senecioyloxy-notonipetranone), 14-deacetylate-1 alpha-methyl butyric acid farfaratin ester (7 β-(3-ethyl-cis-crotonoyloxy)-14-hydroxy-1 α-(2-methylbutyryloxy) notonipetranone), tussilagin (tussilagolactone), 14-removes acetoxy-3,14-dehydrogenation-Z-methylbutanoic acid farfaratin ester (7 β-(3-ethyl-cis-crotonoyloxy)-1 α-(2-methyl butyryloxy)-3,14-dehydroZ-notonipetranone), Triterpenoid: faradiol (faradiol), Arnica glycol (arnidiol), glycosides displayed composition: rutin (rutin), hyperin (hyperin).Also containing cupreol (β-sitosterol), dandelion xanthin (taraxanthin) etc.Spend another containing volatile oil, also containing amino acid, main component is: GABA (γ-aminobutyric acid), alanine (alanine), serine (serine) and glycine (glycine); Again containing inorganic elements: zinc, copper, iron, manganese, cobalt etc.The method of ancients' early useful tussilago burning smoke cough-relieving, just invented before the Song dynasty, " Bencao Tujing " according to Song dynasty pharmacy man Su Song is recorded: " treat chronic cough fumigation, coltsfoot of withdrawing the money every day is permitted by such as chicken; slightly mix with honey; receive in teapot, and with face its lid solid, do not make gas leakage; kettle descends charcoal fire; treat that cigarette goes out from kettle, to suck suction, a few days must imitate." can find out that tussilago burning smoke is sucked treatment and breathed heavily the origin that has a long history of coughing, existing good prevention effect also has the security of sucking.
Utilize modern science and technology condition, the active ingredient of its tussilago is fully extracted, is combined with cigarette, will to improving the quality of cigarette, control is coughed, breathe heavily, the effect of phlegm can play better effect, but there is not yet relevant report in prior art.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, a kind of alcoholic extract paste of common coltsfoot flower is provided, use it in cigarette, to reduce the harm of smoking to human body, particularly for the smoker having cough, asthma, many phlegm, play moistening lung, cough-relieving, the effect of reducing phlegm, alleviate the slight illness of smoker, enrich cigarette kind, improve cigarette quality.
Another object of the present invention is to provide a kind of method preparing described alcoholic extract paste of common coltsfoot flower.
The present invention also aims to provide the application of a kind of described alcoholic extract paste of common coltsfoot flower in cigarette.
Except as otherwise noted, percentage of the present invention is percetage by weight.
The object of the invention is to be achieved by the following technical programs.
A kind of alcoholic extract paste of common coltsfoot flower, be made up of following method: use ethanol extraction tussilago, extract obtains required tussilago farfara extract after clarification filtration and distillation and concentration.
The invention provides a kind of method preparing alcoholic extract paste of common coltsfoot flower, the method comprises the step of following order:
(1) pulverizing of tussilago dry flower mixed with the ethanol of concentration 55-95% for 20-30 order meal, mixed weight ratio is 1: 5-10;
(2) under 20 DEG C of-50 DEG C of conditions, 24h-72h is extracted;
(3) Separation of Solid and Liquid, collects supernatant liquid;
(4) first air-distillation 0.5h at 60 DEG C, then vacuum be 0.01-0.05Mpa, vapo(u)rizing temperature be 15 DEG C of-50 DEG C of conditions under distillation and concentration 1-3h, namely obtain required alcohol extracting tussilago farfara extract.
The invention provides the application of a kind of alcoholic extract paste of common coltsfoot flower in cigarette, concrete mode is: it is 1-5% that the ethanol of the alcoholic extract paste of common coltsfoot flower concentration 95% the present invention prepared is diluted to concentration, then adds in pipe tobacco by the 0.015%-0.05% of pipe tobacco weight.
Preferably by 0.025% of pipe tobacco weight, the alcoholic extract paste of common coltsfoot flower after dilution is added in pipe tobacco.
Preferably with spray pattern, the alcohol extracting tussilago farfara extract after dilution is added in pipe tobacco.
The present invention has following beneficial effect:
(1) tussilago is through ethanol extraction less than 50 DEG C air-distillations with concentrated, can ensure that the active ingredient in its bud is extracted, be retained simultaneously, more can ensure the performance of its active ingredient effect to having the fat-soluble oil component material of volatility;
(2) free amino acid is contained in tussilago; Amino acid can be good at participating in mailland reaction and produces flavor matter in alcoholized tobacco, combustion process, thus enriches cigarette perfume (or spice), reduces and stimulates and assorted gas, be conducive to the mouthfeel pleasant impression improving cigarette;
(3) cigarette prepared of alcoholic extract paste of common coltsfoot flower, can make to breathe heavily and to cough and can not the patient of stopping smoking, in smoking, play moistening lung, reduce phlegm, cough-relieving, the effect of relievining asthma.
(4) application of alcoholic extract paste of common coltsfoot flower in cigarette, does not need the change causing cigarette matter because adding the flavoring substances such as essence, its cigarette fragrance alcohol and, that are good for pleasant impression.
(5) active ingredient in tussilago can fully be extracted by ethanol, and can recycle and reuse, and process of producing product does not exist solvent contamination;
(6) technique is simple, easy and simple to handle, without the need to changing existing production technology, can significantly improve cigarette quality and good practical value.
Detailed description of the invention
Below in conjunction with embodiment and Application Example, the present invention is further illustrated, but they are not limitation of the invention.
Embodiment 1
Take the tussilago meal 1000 grams through pulverizing 20 mesh sieves, load conical flask, add the ethanol 5000ml of concentration 95%, under 30 DEG C of conditions, uniform stirring adds heat soaking 48 hours, carry out Separation of Solid and Liquid with Buchner funnel, collect supernatant liquid, the liquid obtained is first at 60 DEG C of air-distillation 0.5h, then vacuum be 0.025Mpa, vapo(u)rizing temperature be 30 DEG C of conditions under distillation and concentration 1.5h, obtain medicinal extract 15.3 grams.
Embodiment 2
Take the tussilago meal 1000 grams through pulverizing 30 mesh sieves, load conical flask, add the ethanol 7500ml of concentration 75%, under 50 DEG C of conditions, uniform stirring adds heat soaking 24 hours, carry out Separation of Solid and Liquid with Buchner funnel, collect supernatant liquid, the liquid obtained is first at 60 DEG C of air-distillation 0.5h, then vacuum be 0.05Mpa, vapo(u)rizing temperature be 50 DEG C of conditions under distillation and concentration 1h, obtain medicinal extract 15.0 grams.
Embodiment 3
Take the tussilago meal 1000 grams through pulverizing 20 mesh sieves, load conical flask, add the ethanol 10000ml of concentration 55%, under 20 DEG C of conditions, uniform stirring adds heat soaking 72 hours, carry out Separation of Solid and Liquid with Buchner funnel, collect supernatant liquid, the liquid obtained is first at 60 DEG C of air-distillation 0.5h, then vacuum be 0.01Mpa, vapo(u)rizing temperature be 15 DEG C of conditions under distillation and concentration 3h, obtain medicinal extract 14.8 grams.
Application Example 1
By embodiment 1 gained alcoholic extract paste of common coltsfoot flower with 95% ethanol dissolved dilution be for subsequent use after 1% concentration.Under agitation be sprayed on pipe tobacco by 0.015%, 0.025%, 0.05% of pipe tobacco weight respectively, technique makes cigarette routinely, the contrast method of smokeing panel test is adopted to smoke panel test, think that interpolation 0.025% alcoholic extract paste of common coltsfoot flower mouthfeel in pipe tobacco is moderate, with contrast cigarette and compare, have obviously reduce phlegm, cough-relieving, antiasthmatic effect.Smoking result sees the following form:
Application Example 2
By embodiment 1 gained alcoholic extract paste of common coltsfoot flower with 95% ethanol dissolved dilution be for subsequent use after 2.5% concentration.Under agitation be sprayed on pipe tobacco by 0.015%, 0.025%, 0.05% of pipe tobacco weight respectively, technique makes cigarette routinely, the contrast method of smokeing panel test is adopted to smoke panel test, think that interpolation 0.025% alcoholic extract paste of common coltsfoot flower mouthfeel in pipe tobacco is moderate, with contrast cigarette and compare, have obviously reduce phlegm, cough-relieving, antiasthmatic effect.Smoking result sees the following form:
Application Example 3
By embodiment 1 gained alcoholic extract paste of common coltsfoot flower with 95% ethanol dissolved dilution be for subsequent use after 5% concentration.Under agitation be sprayed on pipe tobacco by 0.015%, 0.025%, 0.05% of pipe tobacco weight respectively, technique makes cigarette routinely, the contrast method of smokeing panel test is adopted to smoke panel test, think that interpolation 0.025% alcoholic extract paste of common coltsfoot flower mouthfeel in pipe tobacco is moderate, with contrast cigarette and compare, have obviously reduce phlegm, cough-relieving, antiasthmatic effect.Smoking result sees the following form:
Claims (3)
1. the application of alcoholic extract paste of common coltsfoot flower in cigarette, is characterized in that: by alcoholic extract paste of common coltsfoot flower with 95% ethanol to be diluted to concentration be 1-5%, then add in pipe tobacco by the 0.015-0.05% of pipe tobacco weight; Wherein said alcoholic extract paste of common coltsfoot flower is obtained by following methods: take the tussilago meal 1000 grams through pulverizing 30 mesh sieves, load conical flask, add the ethanol 7500ml of concentration 75%, under 50 DEG C of conditions, uniform stirring adds heat soaking 24 hours, Separation of Solid and Liquid is carried out with Buchner funnel, collect supernatant liquid first at 60 DEG C of air-distillation 0.5h, then vacuum be 0.05MPa, vapo(u)rizing temperature be 50 DEG C of conditions under distillation and concentration 1h, namely obtain alcohol extracting tussilago farfara extract.
2. the application of alcoholic extract paste of common coltsfoot flower according to claim 1 in cigarette, is characterized in that: added in pipe tobacco by the alcoholic extract paste of common coltsfoot flower after dilution by 0.025% of pipe tobacco weight.
3. the application of alcoholic extract paste of common coltsfoot flower according to claim 1 and 2 in cigarette, is characterized in that: added in pipe tobacco by the alcoholic extract paste of common coltsfoot flower after dilution with spray pattern.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210038413.XA CN102578703B (en) | 2012-02-17 | 2012-02-17 | Alcoholic extract paste of common coltsfoot flower and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210038413.XA CN102578703B (en) | 2012-02-17 | 2012-02-17 | Alcoholic extract paste of common coltsfoot flower and preparation method and application thereof |
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| Publication Number | Publication Date |
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| CN102578703A CN102578703A (en) | 2012-07-18 |
| CN102578703B true CN102578703B (en) | 2014-12-17 |
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| CN201210038413.XA Withdrawn - After Issue CN102578703B (en) | 2012-02-17 | 2012-02-17 | Alcoholic extract paste of common coltsfoot flower and preparation method and application thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103524342B (en) * | 2013-10-24 | 2015-09-16 | 重庆大学 | Adopt the method for adjustable ternary solvent system sharp separation tussilagone |
| CN107712192A (en) * | 2017-10-31 | 2018-02-23 | 徐州绿之野生物食品有限公司 | The production method of medicine oolong tea and medicine oolong tea |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1465380A (en) * | 2002-07-19 | 2004-01-07 | 王星杰 | Chinese medicine composition for treating asthma and preparation method thereof |
| CN1704100A (en) * | 2004-05-27 | 2005-12-07 | 江西省药物研究所 | Chinese compound medicinal preparation for treating asthma and method for preparing the same |
| CN1857654A (en) * | 2006-03-21 | 2006-11-08 | 北京阜康仁生物制药科技有限公司 | Trachaitis treating preparation and its preparing process |
| US7323197B1 (en) * | 2006-02-10 | 2008-01-29 | Maria Lukacs | Cigarette/tea system |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030004562A (en) * | 2001-07-05 | 2003-01-15 | 정진남 | Cigarette |
| HRP20010906B1 (en) * | 2001-12-05 | 2006-02-28 | Bukvić Jasenka | Herbal preparation for smoking |
-
2012
- 2012-02-17 CN CN201210038413.XA patent/CN102578703B/en not_active Withdrawn - After Issue
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1465380A (en) * | 2002-07-19 | 2004-01-07 | 王星杰 | Chinese medicine composition for treating asthma and preparation method thereof |
| CN1704100A (en) * | 2004-05-27 | 2005-12-07 | 江西省药物研究所 | Chinese compound medicinal preparation for treating asthma and method for preparing the same |
| US7323197B1 (en) * | 2006-02-10 | 2008-01-29 | Maria Lukacs | Cigarette/tea system |
| CN1857654A (en) * | 2006-03-21 | 2006-11-08 | 北京阜康仁生物制药科技有限公司 | Trachaitis treating preparation and its preparing process |
Non-Patent Citations (5)
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| 《款冬花治疗哮喘及其药理实验的初步观察》;邵长荣等;《上海中医药杂志》;19641027;第4卷(第10期);第12页左栏第1-2段 * |
| 款冬花化学成分的研究;刘玉峰等;《中国中药杂志》;20071115(第22期);第2378-2381页 * |
| 款冬花挥发油的提取及其在卷烟中的应用;闫克玉等;《郑州轻工业学院学报(自然科学版)》;20080415(第02期);第28页第1.2节-1.3节 * |
| 款冬花质量标准研究;刘毅等;《中药材》;20080525(第05期);第761-763页 * |
| 紫菀、款冬配伍中紫菀的祛痰研究;李娜等;《中国临床药理学与治疗学》;20090226(第02期);第159-162页 * |
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