CN102578703A - Alcoholic extract paste of common coltsfoot flower and preparation method and application thereof - Google Patents
Alcoholic extract paste of common coltsfoot flower and preparation method and application thereof Download PDFInfo
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- CN102578703A CN102578703A CN201210038413XA CN201210038413A CN102578703A CN 102578703 A CN102578703 A CN 102578703A CN 201210038413X A CN201210038413X A CN 201210038413XA CN 201210038413 A CN201210038413 A CN 201210038413A CN 102578703 A CN102578703 A CN 102578703A
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- tussilago
- alcohol
- alcoholic extract
- extract paste
- coltsfoot flower
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Abstract
The invention discloses alcoholic extract paste of common coltsfoot flower, a preparation method of the alcoholic extract paste of common coltsfoot flower and application of the alcoholic extract paste of common coltsfoot flower to cigarettes. The method comprises the following steps: after carrying out coarse grinding on common coltsfoot flower, extracting by ethanol, filtering, distilling and concentrating to prepare the alcoholic extract paste product of common coltsfoot flower. When the alcoholic extract paste of common coltsfoot flower is diluted to have the concentration of 1 to 5 percent by ethanol with the concentration of 95 percent and the diluted alcoholic extract paste of common coltsfoot flower is added into tobacco shreds according to 0.015 percent to 0.05 percent of the weight of the tobacco shreds, the cigarette flavor is enriched, the stimulation and miscellaneous gas are reduced, the alcoholic extract paste of common coltsfoot flower is beneficial for improving the aftertaste of the cigarettes and the cigarettes have mellow flavor and excellent aftertaste. The cigarettes prepared by the alcoholic extract paste of common coltsfoot flower can take effects of moistening lung, reducing phlegm, relieving a cough and relieving asthma in the smoking process of a patient who suffers from dyspnea and cough and cannot give up smoking. The quality of the cigarettes can be obviously improved. The alcoholic extract paste of common coltsfoot flower has high practical value.
Description
Technical field
The invention belongs to the cigarette additive preparing technical field, be specifically related to a kind of tussilago alcohol-extracted extract.Also relate to a kind of preparation method of described tussilago alcohol-extracted extract and the application in cigarette thereof simultaneously.
Background technology
Tobacco is one of important industrial crops of China, and cigarette has prevailed in the whole world more than 200 year, can be up to 20th century, and the mankind just begin to recognize the harm of tobacco to the mankind.Smoking is the major incentive of NCDs such as cardiovascular and cerebrovascular disease, cancer and pulmonary emphysema, and the smoker is communicable disease such as easy infection tuberculosis and pneumonia more.Point out that according to " Chinese Control smoking in 2011 report " China becomes maximum tobacco producing country in the whole world and maximum tobacco consumption state with 300,000,000 smokers, China has more than 100 ten thousand people to die from the disease relevant with tobacco every year.But because smoker's the hobby and the dependence of nicotine; Make numerous smokers be difficult to smoking cessation again; Can in cigarette, add some and can remove to cough and breathe heavily and reduce the benefit materials of poisoning, to reduce the murder by poisoning of tobacco to the smoker, be the developing direction that cigarette industry is selected.
Useful medicinal herb components is applied in the middle of the production of cigarettes; Played useful remarkable result; Can reduce the content of harmful in the smog like ZL96117493.5 " a kind of herbal health care type cigarette ", have tonifying kidney and strengthening yang, reduce phlegm, cough-relieving, relieving asthma, strengthen effects such as regulating the human immunologic function.ZL200610054656.7 is that to adopt multiple medium-height grass the effective elements of the medicine be that middle boiling range cut joins in the cigarette filter after with the dilution of 95% ethanol, has tangible cough-relieving, eliminates the phlegm, relievings asthma, alleviation flue gas such as anti-inflammatory is to the dysgenic effect of respiratory system.
Tussilago is classified as treatment by traditional Chinese medicine and breathes heavily the key medicine of coughing, and its effect is generally acknowledged with effect.It is significantly that effect is breathed heavily in its cough-relieving of application in cigarette, as all adopting the tussilago medicinal material in above-mentioned two patents.Patent ZL200710017853.6 then adopts tussilago volatile oil mixed with essence to add and rolls into a kind of Chinese style in the pipe tobacco and fall burnt cigarette with reduced toxicity; Can prevent or alleviate the spread effect of smoke from cigarette to respiratory mucosa; Simultaneously can reduce tar and the nicotine content in the smoke from cigarette; Play and fall burnt attenuation, play moistening lung, reduce phlegm, the effect of cough-relieving.
Tussilago is the dry flower of feverfew coltsfoot Tussilago farfara L..Its medicinal part is its bud part; The validity of its medicinal material is not only its volatile oil part that contains; The preferable effect that wherein a lot of active ingredients embody tussilago is very important; Active ingredient in the tussilago is fully extracted application, could more effectively play antibechic, eliminate the phlegm and antiasthmatic effect.Contain alkaloid in the spending of tussilago: tussilago alkali (tussilagine), renardine (senkirkine); The sequiterpene composition: tussilago ketone (tussilagone) claim farfaratin (tussilagin again; The notonipetranone of 14-acetoxy-7 β-(3-ethylcrotonoyloxy)); Methylbutanoic acid farfaratin fat (α of 14-acetoxy-7 β-(3-ethyl-cis-crotonoyloxy)-1-(2-methylbutyryloxy) notonipetranone); Deacetylate farfaratin (7 β-(3-ethyl-cis-crotonoyloxy)-14-hydroxy-notonipetranone), 7 β-go (3-ethyl croton oil acyloxy)-7 β-Radix Angelicae Sinensis acyloxy farfaratin (14-acetoxy-7 β-angeloyloxy-notonipetranone), 7 β-go (3-ethyl croton oil acyloxy)-7 β-climbing groundsel acyl-oxygen base farfaratin (14-acetoxy-7 β-senecioyloxy-notonipetranone), 14-deacetylate-1 alpha-methyl butyric acid farfaratin ester (7 β-(3-ethyl-cis-crotonoyloxy)-14-hydroxy-1 α-(2-methylbutyryloxy) notonipetranone), tussilagin (tussilagolactone); 14-removes acetoxy-3; 14-dehydrogenation-Z-methylbutanoic acid farfaratin ester (α-(the 2-methyl butyryloxy)-3 of 7 β-(3-ethyl-cis-crotonoyloxy)-1,14-dehydroZ-notonipetranone); Three terpene components: faradiol (faradiol), Arnica glycol (arnidiol); Glycosides displayed composition: rutin (rutin), hyperin (hyperin).Also contain cupreol (β-sitosterol), dandelion xanthin (taraxanthin) etc.Flower contains volatile oil in addition, also contains amino acid, and main component is: GABA (γ-aminobutyric acid), alanine (alanine), serine (serine) and glycine (glycine); Contain inorganic elements again: zinc, copper, iron, manganese, cobalt etc.The method of ancients' useful tussilago burning smoke cough-relieving was early just invented as far back as the Song dynasty before, according to " Bencao Tujing " record of the Song dynasty Su Song of pharmacy man: " treat the chronic cough fumigation; the coltsfoot of withdrawing the money every day such as chicken are permitted, and mix with honey slightly, receive in the teapot; with solid its lid of face, order is leaked gas, and kettle is descending charcoal fire; treat that cigarette goes out from kettle, and to suck suction, a few days must imitate." can find out the tussilago burning smoke suck the treatment breathe heavily the origin that has a long history of coughing, existing good prevention effect also has the security of sucking.
Utilize the modern science and technology condition,, combine with cigarette with the in addition fully extraction of the active ingredient of its tussilago, will be to improving quality of cigarette, prevent and treat cough, breathe heavily, the effect of phlegm can bring into play better effect, but not see relevant report as yet in the prior art.
Summary of the invention
The objective of the invention is to deficiency, a kind of tussilago alcohol-extracted extract is provided, use it in the cigarette to prior art; To reduce the harm of smoking to human body; Particularly to the smoker of cough, asthma, many phlegm is arranged, the effect of play moistening lung, cough-relieving, reducing phlegm alleviates smoker's slight illness; Enrich the cigarette kind, improve the cigarette quality.
Another object of the present invention is to provide a kind of method for preparing described tussilago alcohol-extracted extract.
The present invention also aims to provide the application of a kind of said tussilago alcohol-extracted extract in cigarette.
Except as otherwise noted, the percentage that the present invention adopted is percetage by weight.
The objective of the invention is to be achieved through following technical scheme.
A kind of tussilago alcohol-extracted extract, processed by following method: use the ethanol extraction tussilago, extract obtains needed tussilago medicinal extract after clarification filtration and distillation concentrate.
The invention provides a kind of method for preparing the tussilago alcohol-extracted extract, this method comprises the step of following order:
(1) ethanol of the tussilago dry flower being pulverized to 20-30 order meal and concentration 55-95% mixes, and the mixed weight ratio is 1: 5-10;
(2) under 20 ℃ of-50 ℃ of conditions, extract 24h-72h;
(3) Separation of Solid and Liquid is collected supernatant liquid;
(4) earlier at 60 ℃ of following air-distillation 0.5h, be that 0.01-0.05Mpa, vapo(u)rizing temperature are that distillation concentrates 1-3h under 15 ℃ of-50 ℃ of conditions in vacuum then, promptly obtain required alcohol extracting tussilago medicinal extract.
The invention provides the application of a kind of tussilago alcohol-extracted extract in cigarette; Concrete mode is: use the ethanol of concentration 95% to be diluted to concentration the tussilago alcohol-extracted extract of the present invention's preparation and be 1-5%, the 0.015%-0.05% by pipe tobacco weight adds in the pipe tobacco then.
Preferably by pipe tobacco weight 0.025% with the dilution after the tussilago alcohol-extracted extract add in the pipe tobacco.
Preferably the alcohol extracting tussilago medicinal extract after diluting is added in the pipe tobacco with spray pattern.
The present invention has following beneficial effect:
(1) tussilago with concentrated, can guarantee that the active ingredient in its bud obtains extracting through ethanol extraction air-distillation below 50 ℃, obtains keeping to having the fat-soluble oils component substances of volatility simultaneously, more can guarantee the performance of its active ingredient effect;
(2) contain free amino acid in the tussilago; Amino acid can be good at participating in mailland reaction and produces flavor matter in alcoholized tobacco, combustion process, thereby enriches cigarette perfume (or spice), and reducing stimulates and assorted gas, helps improving the mouthfeel pleasant impression of cigarette;
(3) cigarette of tussilago alcohol-extracted extract preparation can make and breathe heavily the patient who coughs and can not give up smoking, in smoking, plays moistening lung, reduces phlegm, cough-relieving, the effect of relievining asthma.
(4) application of tussilago alcohol-extracted extract in cigarette do not need to cause the variation of cigarette matter because of adding flavoring substances such as essence, and that are good for its cigarette fragrance alcohol and, pleasant impression.
(5) ethanol can fully extract active ingredient in the tussilago, and can recycle and reuse, and there is not solvent contamination in process of producing product;
(6) technology is simple, and is easy and simple to handle, need not to change existing production technology, can significantly improve cigarette quality and good practical value.
The specific embodiment
Below in conjunction with embodiment and application implementation example the present invention is further described, but they are not to qualification of the present invention.
Embodiment 1
Take by weighing tussilago meal 1000 grams, the conical flask of packing into, the ethanol 5000ml of adding concentration 95% through pulverizing 20 mesh sieves; Evenly agitating heating was soaked 48 hours under 30 ℃ of conditions; Carry out Separation of Solid and Liquid with Buchner funnel, collect supernatant liquid, the liquid that obtains is earlier at 60 ℃ of air-distillation 0.5h; Be that 0.025Mpa, vapo(u)rizing temperature are that distillation concentrates 1.5h under 30 ℃ of conditions in vacuum then, get medicinal extract 15.3 grams.
Embodiment 2
Take by weighing tussilago meal 1000 grams, the conical flask of packing into, the ethanol 7500ml of adding concentration 75% through pulverizing 30 mesh sieves; Evenly agitating heating was soaked 24 hours under 50 ℃ of conditions; Carry out Separation of Solid and Liquid with Buchner funnel, collect supernatant liquid, the liquid that obtains is earlier at 60 ℃ of air-distillation 0.5h; Be that 0.05Mpa, vapo(u)rizing temperature are that distillation concentrates 1h under 50 ℃ of conditions in vacuum then, get medicinal extract 15.0 grams.
Embodiment 3
Take by weighing tussilago meal 1000 grams, the conical flask of packing into, the ethanol 10000ml of adding concentration 55% through pulverizing 20 mesh sieves; Evenly agitating heating was soaked 72 hours under 20 ℃ of conditions; Carry out Separation of Solid and Liquid with Buchner funnel, collect supernatant liquid, the liquid that obtains is earlier at 60 ℃ of air-distillation 0.5h; Be that 0.01Mpa, vapo(u)rizing temperature are that distillation concentrates 3h under 15 ℃ of conditions in vacuum then, get medicinal extract 14.8 grams.
Application implementation example 1
It is subsequent use after 1% concentration that embodiment 1 gained tussilago alcohol-extracted extract is used 95% dissolve with ethanol dilution.Under agitation be sprayed on the pipe tobacco by 0.015%, 0.025%, 0.05% of pipe tobacco weight respectively; Process cigarette by common process; Adopt the contrast method of smokeing panel test to smoke panel test; Think that to add 0.025% tussilago alcohol-extracted extract mouthfeel in pipe tobacco moderate, with the contrast cigarette relatively, have obviously reduce phlegm, cough-relieving, antiasthmatic effect.Smoking result sees the following form:
Application implementation example 2
It is subsequent use after 2.5% concentration that embodiment 1 gained tussilago alcohol-extracted extract is used 95% dissolve with ethanol dilution.Under agitation be sprayed on the pipe tobacco by 0.015%, 0.025%, 0.05% of pipe tobacco weight respectively; Process cigarette by common process; Adopt the contrast method of smokeing panel test to smoke panel test; Think that to add 0.025% tussilago alcohol-extracted extract mouthfeel in pipe tobacco moderate, with the contrast cigarette relatively, have obviously reduce phlegm, cough-relieving, antiasthmatic effect.Smoking result sees the following form:
Application implementation example 3
It is subsequent use after 5% concentration that embodiment 1 gained tussilago alcohol-extracted extract is used 95% dissolve with ethanol dilution.Under agitation be sprayed on the pipe tobacco by 0.015%, 0.025%, 0.05% of pipe tobacco weight respectively; Process cigarette by common process; Adopt the contrast method of smokeing panel test to smoke panel test; Think that to add 0.025% tussilago alcohol-extracted extract mouthfeel in pipe tobacco moderate, with the contrast cigarette relatively, have obviously reduce phlegm, cough-relieving, antiasthmatic effect.Smoking result sees the following form:
Claims (6)
1. tussilago alcohol-extracted extract is characterized in that: use the ethanol extraction tussilago, extract makes product after clarification filtration and distillation concentrate.
2. according to the desirable 1 described tussilago alcohol-extracted extract that requires, its preparation method comprises the step of following order: the ethanol that (1) pulverizes the tussilago dry flower for 20-30 order meal and concentration 55-95% mixes, and the mixed weight ratio is 1: 5～10; (2) under 20 ℃～50 ℃ conditions, extract 24h～72h; (3) Separation of Solid and Liquid is collected supernatant liquid; (4) earlier at 60 ℃ of following air-distillation 0.5h, be that 0.01～0.05Mpa, vapo(u)rizing temperature are that distillation concentrates 1-3h under 15 ℃～50 ℃ conditions in vacuum then, promptly obtain alcohol extracting tussilago medicinal extract.
3. require 1 application of said tussilago alcohol-extracted extract in cigarette according to desirable.
4. the application of tussilago alcohol-extracted extract according to claim 3 in cigarette is characterized in that: described tussilago alcohol-extracted extract uses 95% ethanol to be diluted to concentration to be 1-5%, and the 0.015-0.05% by pipe tobacco weight adds in the pipe tobacco then.
5. the application of tussilago alcohol-extracted extract according to claim 4 in cigarette is characterized in that: by pipe tobacco weight 0.025% with the dilution after the tussilago alcohol-extracted extract add in the pipe tobacco.
6. tussilago alcohol according to claim 5 is characterized in that according to the application of medicinal extract in cigarette: with spray pattern the tussilago alcohol-extracted extract after diluting is added in the pipe tobacco.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210038413.XA CN102578703B (en) | 2012-02-17 | 2012-02-17 | Alcoholic extract paste of common coltsfoot flower and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210038413.XA CN102578703B (en) | 2012-02-17 | 2012-02-17 | Alcoholic extract paste of common coltsfoot flower and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102578703A true CN102578703A (en) | 2012-07-18 |
| CN102578703B CN102578703B (en) | 2014-12-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210038413.XA Withdrawn - After Issue CN102578703B (en) | 2012-02-17 | 2012-02-17 | Alcoholic extract paste of common coltsfoot flower and preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103524342A (en) * | 2013-10-24 | 2014-01-22 | 重庆大学 | Method for rapidly separating tussilagone by adopting adjustable ternary solvent system |
| CN107712192A (en) * | 2017-10-31 | 2018-02-23 | 徐州绿之野生物食品有限公司 | The production method of medicine oolong tea and medicine oolong tea |
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| KR20030004562A (en) * | 2001-07-05 | 2003-01-15 | 정진남 | Cigarette |
| WO2003047373A1 (en) * | 2001-12-05 | 2003-06-12 | Jasenka Bukvic | Plant composition for smoking |
| CN1465380A (en) * | 2002-07-19 | 2004-01-07 | 王星杰 | Chinese medicine composition for treating asthma and preparation method thereof |
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| WO2003047373A1 (en) * | 2001-12-05 | 2003-06-12 | Jasenka Bukvic | Plant composition for smoking |
| CN1465380A (en) * | 2002-07-19 | 2004-01-07 | 王星杰 | Chinese medicine composition for treating asthma and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103524342A (en) * | 2013-10-24 | 2014-01-22 | 重庆大学 | Method for rapidly separating tussilagone by adopting adjustable ternary solvent system |
| CN103524342B (en) * | 2013-10-24 | 2015-09-16 | 重庆大学 | Adopt the method for adjustable ternary solvent system sharp separation tussilagone |
| CN107712192A (en) * | 2017-10-31 | 2018-02-23 | 徐州绿之野生物食品有限公司 | The production method of medicine oolong tea and medicine oolong tea |
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| Publication number | Publication date |
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| CN102578703B (en) | 2014-12-17 |
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