CN103110730A - Perillaseed-radix scutellariae-almond decoction for treating asthma and preparation method thereof - Google Patents

Abstract

The invention relates to a perillaseed-radix scutellariae-almond decoction for treating asthma and a preparation method thereof. The perillaseed-radix scutellariae-almond decoction for treating asthma is prepared from the following bulk pharmaceutical chemicals in parts by weight: 15-20 parts of perillaseed, 10-12 parts of almond, 12-15 parts of radix scutellariae, 15-18 parts of semen lepidii, 10-13 parts of lumbricus, 12-15 parts of common hogfenneI roots, 15-20 parts of heartleaf houttuynia herbs, 15-20 parts of honeysuckle, 12-15 parts of white mulberry root-barks, 10-13 parts of radix asteris, 12-15 parts of flos farfarae, and 5-12 parts of licorice roots. According to the compatibility of the decoction, the decoction is given to both cold and heat, and treats both exterior and interior, and the clinical application range is wide. In 50 cases of patients with asthma treated by using the decoction disclosed by the invention, 40 cases of patients have a marked curative effect, 6 cases of patients have an effective curative effect, and 4 cases of patients have no curative effect.

Description

A kind of Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction for the treatment of asthma and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine for the treatment of asthma.

Background technology

Asthma claims again asthma, is a kind of chronic airway inflammation disease take reversible airflow limitation as feature.If inflammation can not get effective control for a long time, Airway Remodeling can appear, cause irreversibility air flue constriction.

At present, the pathologic data of relevant asthma is mostly from the patient's who dies from asthma corpse, and the biopsy specimen of common asthmatic patient.Dissimilar asthma (as: allergic asthma, intrinsic asthma, occupational asthma, aspirin asthma, childhood asthma etc.), its pathological change is basically identical.Substantially see: visible mucus bolt (during concurrent infection, purulent exudate can be arranged) in atelectasis, bronchial lumen, thickens the bronchial wall edema.The visible pulmonary atelectasis in mucus bolt thromboembolism place.The pathological changes of asthma is dispersed throughout whole air flue, but does not involve interstitial lung; Asthma is more serious, and the small airway inflammation is more obvious.Pathological changes can be the kitchen range distribution, the inhomogeneities of visible airway constriction under bronchoscope.

The medicine for the treatment of asthma can be divided into " control outbreak medicine " (controller) and " alleviating the outbreak medicine " (reliever).Controlling the outbreak medical instrument has antiinflammatory action, also claims " anti-inflammatory agent ", and rule can be controlled chronic airway inflammation after using, and reduces and even avoids asthma in acute attack, and pulmonary function is stablized in the Control of asthma development.Alleviating the outbreak medical instrument has bronchorelaxing activity, therefore, also claims " bronchodilatation medicine ", normally uses as required when asthma in acute attack.

Summary of the invention

The object of the present invention is to provide a kind of Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction for the treatment of asthma and preparation method thereof, simultaneously using both cold and hot drugs, the table reason is ruled together.

The technical scheme that the present invention takes is:

A kind of Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction for the treatment of asthma is made by the crude drug of following weight part ratio: Fructus Perillae 15-20 part, Semen Armeniacae Amarum 10-12 part, Radix Scutellariae 12-15 part, Semen Lepidii (Semen Descurainiae) 15-18 part, Pheretima 10-13 part, Radix Peucedani 12-15 part, Herba Houttuyniae 15-20 part, Flos Lonicerae 15-20 part, Cortex Mori 12-15 part, Radix Asteris 10-13 part, Flos Farfarae 12-15 part, Radix Glycyrrhizae 5-12 part.

Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction of described treatment asthma is preferably made by the crude drug of following weight part ratio: 15 parts of Fructus Perillaes, 10 parts, Semen Armeniacae Amarum, 12 parts of Radix Scutellariaes, 15 parts of Semen Lepidii (Semen Descurainiae)s, 10 parts of Pheretimas, 12 parts of Radix Peucedanis, 15 parts of Herba Houttuyniae, 15 parts of Flos Loniceraes, 12 parts of Cortex Mori, 10 parts of Radix Asteriss, 12 parts of Flos Farfaraes, 8 parts, Radix Glycyrrhizae.

The preparation method of Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction of described treatment asthma is:

Add its gross mass 8-20 decocting doubly to boil each crude drug, decoct 2-3 time, each half an hour, collecting decoction.

Fructus Perillae is hot, temperature.Return lung meridian.The sending down the abnormal ascending QI expectorant is relievingd asthma, intestine moistening.

Semen Armeniacae Amarum is bitter, tepor; Slightly poisonous, relieving cough and asthma, loosening bowel to relieve constipation.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, jaundice due to damp-heat, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.

The Semen Lepidii (Semen Descurainiae) nature and flavor are hot, temperature.Warming the lung eliminating phlegm promoting the circulation of QI, the resolving mass and removing the obstruction of the collateral pain relieving.Be used for cold-phlegm and breath with cough, distending pain in the chest and hypochondrium, the stagnant meridians of expectorant, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling.

Pheretima has: diuresis, ease pain, relieving asthma, the effect such as blood pressure lowering, analgesic, convulsion.

The Radix Peucedani dispelling wind and heat pathogens; Lowering the adverse-rising QI to resolve phlegm.Main affection due to external wind and heat; The lung-heat phlegm stagnancy; The cough with asthma abundant expectoration; The expectorant Huang is sticky; Contrary lack of appetite; Chest and diaphragm is full vexed.Be used for cough due to pathogenic wind-heat's abundant expectoration, the expectorant dyspnea of heat type is full, coughs up phlegm yellow thick.

Herba Houttuyniae enters liver, lung two warps.Heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; Inducing diuresis for treating stranguria syndrome.

Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.The sweet cold of its property fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, and also kind removing summer-heat blood poison, be used for various febrile diseases.

The Cortex Mori eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Be used for the lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.

Radix Asteris is root and the rhizome of feverfew Radix Asteris, property of medicine bitter in the mouth; Hot; Warm in nature, return lung meridian, the effect of nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing is arranged.

Flos Farfarae is coltsfoot, and coltsfoot is the alabastrum of Compositae coltsfoot, and property and flavor of peppery and warm has nourishing the lung to keep the adverse QI downward, the effect of the antitussive that reduces phlegm.Record in " herbal classic ": to " pathogenic fluid-retention of cold bundle lung meridian is breathed heavily, coughs the most suitable ".Though abnormal smells from the patient is warm, embellish but not dry, warm heresy, strongly fragrant in lung meridian and must not catharsis person, also can control it.Therefore the cough of Exogenous and internal injuries, cold and heat and asthenia and sthenia all can be used.Particularly chronic cough of deficiency lung is more than, and is the most applicable.

The effect of Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

The hot warm lung qi dispersing of prescription Fructus Perillae of the present invention makes lung qi unobstructed, joins the Semen Armeniacae Amarum Radix Glycyrrhizae, and Xin Wen is loose evil, relieving cough and asthma; The Radix Scutellariae bitter cold, clearing heat and purging lung; Pheretima is salty-cold, and the lung heat clearing spasmolytic makes airway patency rush down phlegm retention; The Radix Peucedani removing heat-phlegm, inducing diaphoresis to expel pathogens; Herba Houttuyniae, Cortex Mori eliminating phlegm; Radix Asteris, Flos Farfarae are cough-relieving good medicine, jointly form removing heat-phlegm, lung qi dispersing spasmolytic, the prescription of relieving cough and asthma.We's compatibility, simultaneously using both cold and hot drugs, the table reason is ruled together, and clinical practice face is wider.Use Drug therapy asthma patient 50 examples of the present invention, produce effects 40 examples, effective 6 examples, invalid 4 examples.

The specific embodiment

Further illustrate below in conjunction with specific embodiment.

Embodiment 1

Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction for the treatment of asthma is made by the crude drug of following weight part ratio: Fructus Perillae 15 grams, Semen Armeniacae Amarum 10 grams, Radix Scutellariae 12 grams, Semen Lepidii (Semen Descurainiae) 15 grams, Pheretima 10 grams, Radix Peucedani 12 grams, Herba Houttuyniae 15 grams, Flos Lonicerae 15 grams, Cortex Mori 12 grams, Radix Asteris 10 grams, Flos Farfarae 12 grams, Radix Glycyrrhizae 8 grams.

Preparation method:

Add the decocting of 8 times of its gross masses to boil each crude drug, decoct 3 times, each half an hour, collecting decoction.

Embodiment 2

A kind of Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction for the treatment of asthma is made by the crude drug of following weight part ratio: Fructus Perillae 20 grams, Semen Armeniacae Amarum 12 grams, Radix Scutellariae 15 grams, Semen Lepidii (Semen Descurainiae) 18 grams, Pheretima 13 grams, Radix Peucedani 15 grams, Herba Houttuyniae 20 grams, Flos Lonicerae 20 grams, Cortex Mori 15 grams, Radix Asteris 13 grams, Flos Farfarae 15 grams, Radix Glycyrrhizae 12 grams.

Each crude drug adds the decocting of 10 times of its gross masses to boil, and decocts 3 times, each half an hour, collecting decoction.

Embodiment 3

A kind of Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction for the treatment of asthma is made by the crude drug of following weight part ratio: Fructus Perillae 18 grams, Semen Armeniacae Amarum 11 grams, Radix Scutellariae 13 grams, Semen Lepidii (Semen Descurainiae) 17 grams, Pheretima 12 grams, Radix Peucedani 13 grams, Herba Houttuyniae 18 grams, Flos Lonicerae 18 grams, Cortex Mori 13 grams, Radix Asteris 12 grams, Flos Farfarae 13 grams, Radix Glycyrrhizae 5 grams.

Each crude drug adds the decocting of 15 times of its gross masses to boil, and decocts 2-time, each half an hour, collecting decoction.

Clinical trial:

Choose the symptom of case:

1. repeatedly show effect dyspnea, wheezing due to retention of sputum in the throat are with cough uncomfortable in chest.

2. two lung audibles and diffusivity wheezing sound when showing effect, obvious during especially with expiration.

3. rabat: the bright degree of two lungs increases, enhanced lung markings.

The treatment or instructions of taking: the medicine with embodiment 1 is potion, every dose one day, three times on the one.

The standard of curative effect evaluation:

Produce effects: the symptom of panting and pulmonary's wheezing sound are clearly better.

Effectively: the symptom of panting and pulmonary's wheezing sound take a favorable turn.

Invalid: the symptom of panting and pulmonary's wheezing sound are without taking a turn for the better or increasing the weight of.

Model case has:

1, Zhu, the man, 40 years old, heating over these days, cough subtracts through treating heat, and cough exacerbates, asthma rale, nausea and vomiting, thirsty polydipsia, loss of appetite, sweating, large dry stool, red tongue with thin and yellow fur.After using five doses of tops, rale is removed, and heat is moved back, and three doses of diseases are removed again.

2, Lin, the female, 30 years old, onset two days, the cough of heating slight perspiration is rough, and flaring of nares is thirsty vexed, lassitude, the little Huang of red tongue tongue, five doses of clothes medicine-feedings, recovery from illness.

3. female, 23 years old, dyspnea occured suddenly after fish and shrimp in the time of 6 years old in patient on the feed, and whistling sound in the throat can not be put down sleepingly, alleviates through treatment.Afterwards often because of improper diet or suffer from cold and show effect, can not spontaneous remission.Because of tired, suffering from cold dyspnea, whistling sound in the throat occur, rale is as shouting, rapid breathing is uncomfortable in chest, the time cough is arranged, the thin color of thin sputum is white, difficulty in expectorating, dark and greenish complexion, thirsty desire for hot drinks, headache, white and slippery fur, stringy and tense pulse or floating tight.Have a medical check-up: T:36.5 ℃, P:90 time/divide, R:22 time/minute, BP:120/80mmHg. nutrition is impartial, grows normally, and two pulmonary respiration sounds are thick, are abound with wheezing sound, and is obvious during especially with expiration.The heart no abnormality seen.Breast abdomen dyskinesis.Remove with wheezing behind five doses of tops, heat is moved back, and five doses of diseases are removed again.

Claims (3)

1. Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction for the treatment of asthma, made by the crude drug of following weight part ratio: Fructus Perillae 15-20 part, Semen Armeniacae Amarum 10-12 part, Radix Scutellariae 12-15 part, Semen Lepidii (Semen Descurainiae) 15-18 part, Pheretima 10-13 part, Radix Peucedani 12-15 part, Herba Houttuyniae 15-20 part, Flos Lonicerae 15-20 part, Cortex Mori 12-15 part, Radix Asteris 10-13 part, Flos Farfarae 12-15 part, Radix Glycyrrhizae 5-12 part.

2. Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction for the treatment of asthma according to claim 1, is characterized in that, made by the crude drug of following weight part ratio: 15 parts of Fructus Perillaes, 10 parts, Semen Armeniacae Amarum, 12 parts of Radix Scutellariaes, 15 parts of Semen Lepidii (Semen Descurainiae)s, 10 parts of Pheretimas, 12 parts of Radix Peucedanis, 15 parts of Herba Houttuyniae, 15 parts of Flos Loniceraes, 12 parts of Cortex Mori, 10 parts of Radix Asteriss, 12 parts of Flos Farfaraes, 8 parts, Radix Glycyrrhizae.

3. the preparation method of Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction for the treatment of asthma claimed in claim 1,, it is characterized in that,

Add its gross mass 8-20 decocting doubly to boil each crude drug, decoct 2-3 time, each half an hour, collecting decoction.