KR100522176B1 - Composition for improving male sexual function - Google Patents

Abstract

The present invention relates to a composition for improving sexual function, including bellflower, ginseng, mountain lion, old plate, Angelica, baekchul, tangerine, earth and sand, raw yellow sulfur, Schisandra chinensis, casualty, sewage, and wolfberry. The composition of the present invention may further include soybean, bokyeong, jujube, honeysuckle, buckwheat, baekbaek, mugwort, ginger, dew, sweet ginseng, ginseng, stone spear, peony, shiraza, lotus root, 칡, licorice, turmeric, green tea, gardenia, honey, Samsam, Cinnamon, Aloe Ash, Safflower, Underwear, Deodeok, Okmok Calligraphy, Crude, Astragalus, Dough, Perilla, Sanjoin, and Toxin.

Description

Composition for improving male sexual function

The present invention relates to a composition for improving sexual function in men, including bellflower, ginseng, mountain lion, old plate, Angelica, baekchul, tangerine, earth and sand, raw sulfur, Schisandra chinensis, casualty, sewage, and wolfberry.

Men's sexual dysfunction can be divided into sexual neural hypersensitivity caused by erectile dysfunction or impotence necessary for sexual activity and loss of ejaculation control.

Erectile dysfunction generally refers to erectile dysfunction, which is a sexually functional impotence, persistent erections in which the penis is persistent and painful, and disorders of the cavernous tissue of the penis and associated fascia. Erectile dysfunction is caused by psychologic impotence, organic impotence, or a combination of both. The matrix erectile dysfunction is classified into neurogenic, vascular, and endocrine dysfunction. Degradation of sexual function is closely related to deterioration of biological function and, in severe cases, can lead to chronic erectile dysfunction.

In addition, sexual hypersensitivity caused by the loss of ejaculation control is one of the male sexual dysfunctions as well as erectile dysfunction. Sexual hypersensitivity is known to be caused by a loss of balance between the peripheral nervous system and central nervous system and loss of sexual control due to inability to maintain a cooperative system. A typical example of such hypersensitivity is premature ejaculation, which is a symptom of premature ejaculation in men.

Most of the sexual function improvers developed so far are mainly used as medicines for people with severe sexual dysfunction such as erectile dysfunction. Such erectile dysfunction treatment agents are largely divided into three types according to the mechanism of action. First, indirectly promotes erection by inhibiting an enzyme called PDE5 (Phosphodiesterase type-5), which exists in the erectile tissue and interferes with the expansion of the corpus cavernosum. Viagra, which contains cidenate sildenafil as an active ingredient, Levitra based on vardenafil from Bayer / GSK, and Cialis based on tadalafil from Lil1y / ICOS. However, in case of Viagra, when nitrate is taken together with a medicine related to heart disease, there is a drawback that a risk of life may be caused by a drop in blood pressure. Second, Pharmacia's Caverject, VIVUS's Muse, and NexMed's loquat (PGE1, Prostaglandin El), which acts directly on erectile tissues to dilate blood vessels. Befar). Third, there is Abbott's Uprima, which is based on apomorphine, a dopamine agonist that acts on dopamine Dl / D2 receptors in the brain. In addition to these, α-adrenergic receptor antagonists, guanylyl cyclase stimulators, and serotonin (5-hydroxytryptamine) receptor agonists have been developed.

Psychotherapy and drug therapy are used for the treatment of sexual hypersensitivity, but drugs commonly used are psychotropic drugs that suppress the excitability of the central nervous system or agents for local anesthesia for the slowing of the sexual peripheral nerve. However, when the central nervous system is suppressed, there is a possibility that sexual activity itself is impossible due to sexual loss, and local anesthetics cause erectile dysfunction due to vasoconstriction and have a short duration.

In addition to the therapeutic agent based on such specific chemicals, it is known to improve the sexual function of the food concept using a natural product extract. For example, "Methods and compositions for promoting libido", including combinations of L-arginine, ginseng, ginkgo biloba and damiana (Korean Application No. 2003-7015701), erectile dysfunction by having cGMP phosphodiesterase inhibitory activity Or "composition for improving sexual dysfunction, including ginseng extract", which contains a flavonoid compound that can be used to improve sexual dysfunction, such as erectile dysfunction, or a ginseng extract comprising the same as an active ingredient (Korean Application No. 2002-0026650), "Red ginseng complex for improving sexual function, uses and preparation methods thereof" including red ginseng extract and gojija, bokbunja, earth and sand, Schisandra chinensis and filamentous extract (Korean Application No. 2001-0067580), Yin Yang Kwak, Seokchangpo, Dermis, Angelica, Ogapi, etc. "Functional composition having an antioxidant effect and an effect of promoting the growth of intestinal useful bacteria" prepared using extracts Application No. 2001-0046355), "Functional food for improving male sexual function" containing bokbunja, cornus, red ginseng, sea cucumber and royal jelly (Korean patent application No. 1020010028987), red ginseng extract powder, moon dog oil, egg yolk oil, beeswax, soybean oil and "Erection composition for improving erectile dysfunction comprising lecithin and food containing it" (Korean patent application No. 1020010011429), "Food composition for preventing and treating sexual dysfunction, including goat milk" using goat milk, goat milk concentrate, goat milk fermented milk "(Korean patent Patent No. 1020000026442) has been filed.

As described above, the existing products related to sexual function are largely divided into two classes, namely, erectile dysfunction using chemicals and improving agents using natural products. Conventional sexual enhancers, especially erectile dysfunction treatment products, were developed to give an immediate erectile effect rather than to improve sexual function through the improvement of normal human physiological function, these products may have a temporary erection effect, but normal physiological function is destroyed This can lead to a decline in physical fitness and life-threatening side effects. In addition, the sexual function improving agent using a natural product showed a temporary effect or the effect of improving the sexual function is insufficient. Therefore, it is necessary to develop a therapeutic agent that effectively improves sexual function by activating normal physiological functions of the human body without being harmful to the human body.

Whereas conventional sexual function improvers only give a temporary effect irrespective of the physical strength and side effects of the human body, the composition of the present invention first supplements the lack of physical strength, or energy of the human body, and thus the effect gradually begins to appear as a mechanism for enhancing sexual function. After a certain period of time as a composition consisting of a natural extract showing a continuous effect proved the efficacy of sexual improvement through clinical trials.

Accordingly, it is an object of the present invention to provide a herbal composition that effectively improves sexual function without toxic side effects by activating normal physiological function of the human body.

In one embodiment, the present invention provides a composition for improving male sexual function, including bellflower, ginseng, mountain lion, old plate, donkey, baekchul, tangerine, earth and sand, raw yellow sulfur, Schisandra chinensis, casualty, sewage, and wolfberry.

In a preferred embodiment, the composition of the present invention, based on the total amount of the composition, 0.2 to 15% by weight bellflower, 0.2 to 15% by weight ginseng, 0.1 to 7% by weight hawthorn, 0.1 to 7% by weight spheres, 0.3 to 20% by weight of Angelica %, White 0.2 ~ 15 wt%, 1 ~ 40 wt% of tangerine, 0.1 ~ 7 wt% of earthworms, 0.2-15 wt% of raw earthworm, 0.1-7 wt% of Schisandra chinensis, 0.1-7 wt% of Scavenger, 0.1-7 wt% of sewage , And 0.2-15% by weight of wolfberry.

In a more preferred embodiment, the composition of the present invention, based on the total amount of the composition, 1 to 10% by weight bellflower, 1 to 10% by weight ginseng, 0.5 to 5% by weight of lioness, 0.5 to 5% by weight of spheres, Angelica 1.5 to 12 Wt%, 1 to 10% by weight, 3 to 20% by weight of tangerine, 0.5 to 5% by weight of earth and sand, 1 to 10% by weight of raw earth sulfur, 0.5 to 5% by weight of Schisandra chinensis, 0.5 to 5% by weight of sewage, and 0.5 to 5% by weight of sewage %, And 1 to 10% by weight wolfberry.

As a further aspect, the composition of the present invention is soybean, Fukryeong, jujube, indong, buckwheat, baekbaek, mugwort, ginger, dew, sweet ginseng, mansam, quarry, peony, shiraza, lotus root, 칡, licorice, turmeric, green tea, gardenia , Honey, ginseng, cinnamon, aloe hoe, safflower, underwear, deodeok, Okmok calligraphy, crude, Astragalus, weak wheat, perilla, sanjoin, or poisonous composition for improving male sexual function is further included.

In a preferred embodiment, the composition of the present invention, based on the total amount of the composition, 1 to 3% by weight, 1 to 3% by weight of ginseng, 0.5 to 2% by weight of lioness, 0.5 to 2% by weight of spheres, 1.5 to 5% by weight of Angelica %, Baekchul 1 to 3% by weight, 3 to 10% by weight of tangerine, 0.5 to 2% by weight of earthworms, 1 to 3% by weight of raw yellow sulfur, 0.5 to 2% by weight of Schisandra chinensis, 0.5 to 2% by weight of sewage, 0.5 to 2% by weight of sewage , 1 to 3% by weight of wolfberry, 1 to 3% by weight of soybean, 0.5 to 2% by weight of Bokryeong, 1.5 to 5% by weight of jujube, 0.5 to 2% by weight of phosphorus, 0.5 to 2% by weight of buckwheat, 3 to 6% by weight, Mugwort 1-3 wt%, Ginger 3-7 wt%, Peony 2-8 wt%, Walnut 0.5-2 wt%, Salvia 0.5-2 wt%, Mansam 0.5-2 wt%, Seokchangpo 1-3 wt%, Syrah 1 to 3% by weight, lotus root 1 to 3% by weight, 칡 1 to 3% by weight, licorice 3 to 7% by weight, turmeric 0.5 to 2% by weight, green rust 0.5 to 2% by weight, gardenia 0.5 to 2% by weight, 5 to 20% by weight of honey, 1 to 3% by weight of ginseng, 0.5 to 3% by weight of cinnamon, 1 to 3% by weight of aloe ash, 1 to 3% by weight of safflower, 1 to 3% by weight of narcissus, Deodeok 1 To 3% by weight, 1 to 3% by weight of the oxalic calligraphy, 1 to 3% by weight, 0.5 to 2% by weight of astragalus, 0.5 to 2% by weight of wild buckwheat, 1 to 3% by weight of perilla, 0.5 to 2% by weight of acid and 0.5 To 2% by weight.

In a more preferred embodiment, the composition of the present invention, based on the total amount of the composition, 2% by weight of bellflower, 2% by weight of ginseng, 1% by weight of lioness, 1% by weight of spheres, 3% by weight of Angelica, 2% by weight of white extract, Weight%, Tosa 1% by weight, Raw Sulfur 2% by weight, Schisandra chinensis 1% by weight, Casualty 1% by weight, Sewage 1% by weight, Wolfberry 2% by weight, Soybeans 2% by weight, Fukryeong 1% by weight, Jujube 3% by weight, Phosphor 1 Wt%, buckwheat 1%, total bag 5%, mugwort 2%, ginger 5%, peony 4%, dew 1%, salvia 1%, manssam 1%, stone spear 2%, shiraza 2% by weight, 2% by weight lotus root, 2% by weight, licorice 5%, turmeric 1%, green angle 1%, gardenia 1%, honey 10%, sasam 2%, cinnamon 1%, aloe Ash 2% by weight, safflower 2% by weight, innerwear 2% by weight, deodeok 2% by weight, octac calligraphy 2% by weight, crude 2% by weight, Astragalus 1% by weight, weak wheat 1% by weight, perilla 2% by weight, Sanjoin 1% %, 1% by weight of venom.

The above-described herbal medicines included in the composition of the present invention will be described in detail:

The bellflower is the root of the Platycodon grandiflorum A. de Candolle, or the skin of the bellflower is removed. It contains components such as saponin, betulin, phytosterol, and has expectorants, blood sugar lowering, cholesterol lowering, and vasodilation.

Ginseng is the root of Panax ginseng of the Ogalpiaceae. It contains substances such as saponins, sesquiterpenoids, polyacetylenes, flavonoids, and it is effective in controlling the digestive organs and metabolic diseases and health.

The hawthorn is the fruit of the hawthorn (Crataegus pinnatifida Bunge var. Typica Schneider) and the same plant. Amygdalin (amygdalin), quercetin (quercetin) and other ingredients are present, and gastric juice secretion, antibacterial, coercive action.

Gupan is the abdomen of Chinese tortoises (Chinemys reevesii Gray), rich in calcium salts, fats and colloids, and is effective in nourishing, tonic, blood, pulmonary tuberculosis, seawater and oil wells.

Angelica refers to drying the roots of Angelica gigas NAKAI, dried roots of Angelica sinensis in China, and dried roots of Angelica acutiloba KITAGAWA in Japan. . It contains essential oils, decursin, and umbelliferon, and it is an effective supplement to the effects of blood and tonic, blood and blood, and is effective in treating women's postpartum disease, anemia and headache. Has been.

Baekchul removes root stem or bark of Atractylodes japonica Koidzumi or Atractylodes ovata Koidzumi, which contains ingredients such as atractylon, and is an aromatic nutrient agent that enhances the spleen in Chinese medicine. Frequently used for non-prescriptions, it has a calming, diuretic, latent, nourishing and anxious effect

Mandarin Peel is the fruit peel of the evergreen big-key tangerine tree with rhyme. Tastes sour, strengthens the digestive system, treats only the abdominal window, trim vomiting, nausea, indigestion and flatulence. The tangerine contains 1.5 ~ 2% of essential oils, and its ingredients include limonene, isopropenyl toluene, 8-elemene, d-copaene and alpha-humulene , Vitamins B and C, and more.

The earthenware dried seeds of the year-old parasitic ginseng and related plants belonging to the meeraceae. Tosa has a taste, sweetness and plain properties. It is effective in protecting cancer, strong heart, lowering blood pressure, lowering blood sugar, and renal and spleen. It is used as a tonic in Chinese medicine for gastrointestinal tract, oil well and low back pain. It is also used as a sedative, painkiller and diarrhea. In the private sector, the face is washed with starch juice to remove papules. It is also used as a sputum and blood drops.

Raw grasses refer to the roots of perennial perennial (Rehmannia glutinosa Liboschitz) and Rehmannia glutinosa Libosch.for.hueichingensis Hshlao. Saenghwanghwang is good for diabetes, stop bleeding, nosebleeds, uterine bleeding, menstrual irregularities, constipation is good. Ingredients include beta-sistosterol, trace amounts of campesterol, rehmanin, alkaloids, fatty acids and the like. Pharmacologically lowering blood sugar, acting on the circulatory system has a strong heart and diuretic effect, there is a liver function protection, and antibacterial action.

Schisandra chinensis is a fruit of Schizandra chinensis. Schisandra, sweet, bitter, salty, spicy five kinds of taste is called Schisandra chinensis, it is used for nourishment, tonic, expectoration, and dark. Fruits contain schzandrol, schzandrin A, B, C, gomisin and the like.

Casualties are the fruit of the herbaceous tortoise (Torilis japonica), mainly known as gynecology, otolaryngology and skin pruritus.

Sewage is a tuber of Polygonum multiflorum Thunb. It contains ingredients such as crysophanol (crysophanol) and emodin (dead), blood, gangjeong, tonic action.

Chinese matrimony vine is the fruit of the goji tree, which brightens the eyes, maintains youth, and is used as a long-lived herb. It contains putin, betaine, tannin, amino acids, vitamins, and protein. Recent research results include research on improvement, anti-cancer, immune enhancement, liver function and blood pressure lowering. It is a kind of herbal medicine used as.

Soybean is a seed of Glycine max of legumes, black is called black bean, yellow is yellow bean, and there are other kinds of white, brown, blue, and speckled. It is rich in nutrients such as protein, fat, carbohydrates and vitamins, and is consumed as food.

Fu-ryeong is the dried core of Poria cocos (Fr) Wolf. It is not good to urinate, it is effective for the symptoms of swelling of the stomach and the whole body, sea water, vomiting, diarrhea and heart beats and surprises, and treats forgetfulness and oil well. It also has a remarkable response to renal edema. The most common component is beta-pachymic, which contains about 90%, and contains pachyn \ mic acid, protein, and glucose. It is effective in preventing ulceration caused by pyloric ligation in rats, and polysaccharide is effective in immune enhancing function and chronic schizophrenia in malignant tumor and improves liver function.

Jujube is the fruit of Zizyphus jujuba Miller var. Inermis Rehder, which contains oleanonic acid, betulic acid, and saponin, and has the effect of tonic, blood, relaxation, and sedation.

         Phosphorus is a dried stem and leaf of the phyllophora (Lonicera japonica Thunb.), Which contains components such as luteolin and loniceroside. It has analgesic action.

Buckwheat is a perennial herb of barkweed. It is a starch crop and has high protein content, contains vitamins B1, B2, and nicotinic acid, which is high in nutrients, high in fiber, and contains rutin.

Chongbaek is a fresh scaly stem of the allium fistulosum L. belonging to the family Liliaceae. It is used as an active ingredient in allicin, diallyl-monosulfide, etc.

Mugwort is a perennial herb that uses the leaves of herbaceous wormwood. It is mainly effective for cold diseases by controlling digestive, dermatological and gynecological diseases.

Ginger is a fresh rhizome of ginger (Zingiber officinale Rosco), and contains essential oils such as zigiberene and sour ingredients such as ginerol and shogaol. Suppression of spontaneous movement, fever, analgesic action has been used a lot as a medicine in oriental medicine.

Peony is a dried peony, peonyflorin, monoterpine, and terpinoid glycoside, which is dried and dried after removing the outer skin of the root of the same plant. It is a medicinal herb, analgesic, and astringent medicine, which is used as a blood donation medicine, and is formulated for prescriptions aimed at anti-inflammatory phrenic blood, earth and drainage.

The hyssop refers to the basement of Achyranthes japonica Miq. MAKAI, which may use the roots of Achyranthes bidendata BLUME, Cyathula officinalis KUAN, and Cyathula capita. It has been known that hyssop has the effect of bleeding and pain through the joint by eliminating the cold and moisture of mock, and the effect of interpolation and Iksan by strengthening the musculature.

Salvia is the dried root of Salvia miltiorrhiza Bunge . It contains tanshinone and cryptotanshinone, and has been used to treat blood, landscaping, swelling, analgesia, and liver.

Mansam is the root of perennial herbaceous vines, which are called Samseongdeok, Chamdeokdeok, Dangsam, and Jommansan. It contains saponin, alkaloids, proteins, vitamins B1 and B2. It is a kind of tonic that helps to keep the stomach in stomach and produce essence and stops dry mouth. It is applied to stomach weakness, anorexia, diarrhea and fatigue.

Seokchangpo is a root stem of Acorus gramineus Solander, which contains essential oils and components such as beta-asarone and caryophyllene, and has a calming, dry, painful, diuretic and antifungal effect. Known.

Shiraza is the fruit of Anethum graveolens L., essential oil contains carvone, limonene, xanthone, glycoside, etc. .

Lotus root is the root of perennial herbaceous lotus (Nelumbo nucifera Gaertn), which belongs to the water lily family. The main component is sugar, most of which is starch, and as amino acids, aspartic acid, ilanine, tyrosine, and vitamin B12. Energetic tonic, fatigue recovery, mental stability, lung disease, anemia, bleeding, each is effective.

Root is the root removed from the leg of the legume (Pueraria lobata Bentham). It contains isoflavonoids such as starch and daidzein and triterpinoids, and is used as antipyretic, sweating, antifungal, etc. For herbal remedies, it is often formulated as a prescription for colds and antipyretic analgesics.

Licorice is peeled or intact the roots and gourds of legume licorice (Glycirrhiza glabra L., G uralensis Fisher) or the same plant. Glycyrrihizin, liquid, such as liquid (liquiritin), and is widely used, such as antitussive expectoration, jingyeong, peptic ulcer treatment.

Turmeric is dried and dried by removing the bark of curcuma longa L. with curcumin, essential oils and sterols, and promoting bile secretion, pain medication, and liver disease pills. It is used for gallstone disease.

Green rust is a keratinized horn of various deer, such as manok or plum rust, which belongs to the family Deer. It is used as an energetic agent for the improvement of physical strength, the immune boosting effect of the body, and the weakness of the spirit and blood.

Gardenia is a ripe fruit of Gardenia jasminoides Ellis for.grandiflora Makino, the evergreen evergreen tree of the ragweed family. Gardenia gardenia (gardenoside), gardenin (gardenin), crocin (crocin), crocetin (crocetin), geniposide (taniposide), and tannins are contained. There is soothing and analgesic action and it acts to lower blood pressure by tense parasympathetic center. Treats strawberry nose due to excessive drinking, promotes the secretion of bile and acts to protect the liver.

Honey is a collection of sweet substances collected in bee bees and honey bees. Sugars such as invert sugar and sucrose, amino acids and organic acids are present, and are used for fatigue recovery, sweet nutrition, bowie, detoxification and constipation.

Korean ginseng is the root of Adenophora triphylla var. Japonica and has been used as an antitussive, expectorant, antipyretic, tonic, and draining agent.

Cinnamon refers to the use of bark of Cinnamomum cassia BLUME and Cinnamomum aromaticum Nees as it is, or to remove the bark. It has a unique fragrance and sweet and spicy taste.

Aloe ash is the dried juice of aloe (Aloe ferox Miller) or hybrids of this plant with A. africana Miller or A. spicata Baker. Anthrone glycoside, barbaloin, is the main ingredient and is used in laxative and tonic medicines.

Safflower refers to the drying of the ornamental flower of Asteraceae (Carthamus tinctorius L.), which is dried in summer when the flower color changes from yellow to red and used in a cool place. In oriental medicine, blood circulation disorders such as gynecological diseases, coldness and menopausal disorders It is known for use in therapy.

The undergarment is a radish (Raphanus sativas L.), which is also used for food or medicinal purposes. It is known to control respiratory diseases and benefit health.

Deodeok is the root of the bellflower Codonopsis lanceolata, which mainly cure urinary, circulatory and nervous diseases and is effective in respiratory diseases.

Okmok calligraphy is a fresh shipper and teapot of Zea mays L., which includes sodium nitrate, sitosterol, stigmasterol, vitamin K, and the like. It is used to treat acute nephritis, pregnancy edema, cystitis, etc.

Cho is an annual herb that is used as a flower, and is used for mixing with rice or barley. It has also been used for malt, rice cake, and shochu.

Astragalus is the bark of the bark of the Astragalus membranaceus Bunge. Contains flavonoids, triterpinoids, and other substances. Tonic, cardiac, and diuretic antiperspirants are used for weakness, malnutrition, sweating, acute or chronic nephritis. Weak wheat is an outpost of Houttuynia cordata, a perennial grass belonging to over three hundred, and is also called Eoseongcho. Essential oils of methylnonyl ketone, myrcene, laurinaldehyde, caprinaldehyde, and capric acid are present, and it is known to be used for gonorrhea, urethritis and cystitis as inflammatory drugs and diuretic poisoning drugs.

Perilla frying perilla fryingscense var. Japonica Hara is also used to dry seeds. It contains ingredients such as perillaketone and isoegomaketone. It is used in the private sector to prevent high blood pressure and various adult diseases. It is also used as cooking oil. In oriental medicine, it is used for Jinhae, expectorant, and yunjangjang.

Sanjoin is the seed of Zizyphus jujuba MILL. Sanjoin contains fatty oils, saponins, triterpin compounds, betulin, jujuboside, betulic acid, vitamin C, and the like. Calm, hypnotic and lower blood pressure constantly. It has antioxidant and immune boosting effects. There are clinical cases that improve the various types of weakness invented at night and take good treatment effect by taking 60g of ginseng powder and 6g of ginseng on the symptoms of men's inability to ejaculate.

The poisonous tree is Aralia continentalis (or A. cordata), a perennial herb of the elderaceae, whose roots include essential oils such as limonen and sabinene, and kaurenic acid ((-) kaur-16-en-19-oic acid, etc., and it is known to be effective in treating swelling, chemistry, sweating, pain, diarrhea, diuresis, swelling, excursions, bohemia, headache, migraine, rheumatism and neuralgia.

The herbal medicines of the composition of the present invention are all safe even when the excess is used as a food ingredient harmless to the human body registered in the Food Code.

Fatigue and indigestion are factors that reduce energy, which is known to cause many disorders. These factors do not fundamentally improve, that is, stamina cannot be sustained. With this in mind, the present inventors first attempted to develop a composition having excellent efficacy for restoring the fatigue of the human body, making the stomach strong, supplementing the energy by helping to restore the liver function, and improving the sexual function by normalizing the function of the human body. .

The composition of the composition of the present invention is clearly different in composition from the composition based on the natural products disclosed before the present invention, does not contain a herbal medicine such as cornus oil that burdens the stomach or liver, these components are used together to raise It has an effect of action. Animal model experiments using the composition of the present invention showed no side effects, shortened mating behavior time, increased number of mating behaviors and increased insertion times. In addition, the testosterone content in the blood also showed an excellent effect on improving sexual function.

Prior to the present invention, there have been no reports of improving sexual function by smoothing the circulatory system. In the improvement of sexual function, the composition of the present invention is a composition that is clearly different in function and mechanism of action from conventional medicines that simply induces an erection since it restores the metabolic function of the human body, in particular, facilitates the circulatory system and restores sexual function. In contrast to the conventional erectile stimulator, an erectile stimulator exhibits side effects that can be deadly or life-threatening, and has only a temporary effect, the composition of the present invention first replenishes the lack of physical strength, that is, energy, thereby improving sexual function. Let's do it. For this reason, the composition of the present invention gradually starts to show an effect and shows a continuous effect after a certain period of time.

The herbal medicines included in the composition of the present invention may be used after being powdered as they are or extracted using water, alcohol or an organic solvent. In the case of powdering, all the herbal medicines can be powdered simultaneously or individually powdered and mixed. Alternatively, in the case of extraction, all the herbal medicines can be extracted at the same time or the individual herbal medicines can be extracted under optimum conditions and mixed to obtain an extract. Alternatively, some herbal medicines may be powdered and the remaining herbal medicines may be extracted to mix the two to prepare a composition. The extracts may be fraction extracts purified using various separation and purification methods.

The powdering of the present invention may use methods known to those of ordinary skill in the art. Extraction methods include, but are not limited to, extraction with water, alcohol, or mixed solvents, extraction with a bath or room temperature, and the like. In the case of extraction with water, water may be added to the herbal medicine of the present invention and heated at a temperature not exceeding 100 ° C. for at least 1 hour, and the heated mixture may be prepared by filtration. When heating at a high temperature, the time is reduced, but the active ingredient may be destroyed and lost. When heating at a temperature lower than the temperature, it is important to control the temperature and the time properly because the active ingredient of the mixture is not completely extracted. The extract may be dried or used as it is. When extracted with an organic solvent, using methanol, ethanol, isopropanol, butanol, ethylene, acetone, ether, hexane, chloroform, ethyl acetate, N, N- dimethylformamide, dimethyl sulfoxide and the like at room temperature It can be extracted with an organic solvent.

Preferably, the composition of the present invention is prepared by first cooling the vessel containing the herbal medicine as described above in a vessel containing water for 2 days or more, and then cooling with running water for 1 day or more, and then water bathing for 1 day or more. do. In the preparation of such a bath, the container containing the herbal medicine can be preferably used in conventional Onggi. Preferably, the first bath is performed for 3 days to 5 days, and the second bath is preferably performed for 1 day to 2 days. The manufacturing method by such a bath method does not destroy the characteristics of the herbal medicines because the bath temperature does not exceed 100 ℃.

The composition of the present invention is used as a powder, an extract, or a mixture thereof, or in the form of a solid preparation, a dispersing preparation, a semisolid preparation, a liquid preparation, or the like according to a conventional method. , Pills, powders, granules, tablets, capsules, injections, extracts, acupuncture or tincture. The compositions of the present invention may be included in one or more pharmaceutically acceptable carriers, excipients, or diluents for formulating them.

The composition of the present invention can be administered through various routes, such as oral, parenteral, etc. in an amount effective for improving sexual function, and the effective dose level is the type of disease and its severity, the activity of ingredients, the age, weight, health, sex of the patient. , The sensitivity of the patient to the drug, the time of administration, the route of administration and the rate of drug loss, the duration of treatment, factors taking into consideration the drug used in combination or concurrent with the particular extract or powder used, and other factors well known in the medical arts. . In general, in the case of high dosage forms, 10 g to 200 g, preferably, 50 g to 100 g may be administered once to three times a day.

Hereinafter, the present invention will be described in more detail with reference to specific examples, but the present invention is not limited to the examples listed herein.

Preparation Example 1 Preparation

Bellflower 2%, Ginseng 2%, Lioness 1%, Old Pan 1%, Angelica 3%, Baekchul 2%, Tangerine Blood 7%, Tosa 1%, Fresh Green Sulfur 2%, Schisandra 1%, Casualties 1%, Sewage 1%, Goji 2 %, Soybean 2%, Bokryeong 1%, Jujube 3%, Indong 1%, Buckwheat 1%, Total white 5%, Mugwort 2% Ginger 5%, Wool 1%, Sweet Ginseng 1%, Ginseng 1%, Seokchangpo 2% Peony 4 %, Shiraza 2%, Lotus root 2%, 칡 2%, Licorice 5%, Turmeric 1%, Green Ginseng 1%, Gardenia 1%, Honey 10%, Sasam 2%, Cinnamon 1%, Aloe ash 2%, Safflower 2 2%, underwear 2%, deodeok 2%, Okmok calligraphy 2%, crude 2%, Astragalus 1%, weak buckwheat 1%, perilla 2%, Sanjoin 1%, and 1% poison. A crutch was placed on the inner bottom of the water bath, filled with water, and a jar of herbal medicine was placed on the crutch. Water was filled between the bowl and the poison, and mulberry trees were used as a firewood to set fire. Subsequently, the bath was cooled in running water for 1 day until it was brought to room temperature, and then heated again and heated for 1 day. The resulting gourd was placed in pottery.

In addition, the powder prepared above was put in a dryer, dried, and then ground to prepare a powder.

Preparation Example 2 Preparation

Bellflower 2%, Ginseng 2%, Lioness 1%, Angelica 3%, Baekchul 2%, Mandarin Peel 7%, Sewage 1%, Soybean 2%, Bokryeong 1%, Honey 1%, Mugwort 2%, Wool 1%, Dansam 1 %, Ginseng 1%, Seokchangpo 2%, Peony 4%, Shiraza 2%, Soap 2%, Sasam 2%, Cinnamon 1%, Licorice 5%, Deodeok 2%, Ok calligraphy 2%, Crude 2%, Weak wheat 1 % And 1% virulence were powdered.

Old Plate 1%, Tosa 1%, Sanjoin 1%, Buckwheat 1%, Schisandra 1%, Casualty 1%, Gugija 2%, Jujube 3%, Turmeric 1%, Gardenia 1%, Aloe ash 2%, Safflower 2%, Astragalus 1% was mixed and bathed for 3 to 5 hours to avoid breakage of the components. Green rust 1% was extracted with a high pressure extractor for 3 days.

Fresh sulfur 2%, ginger 5%, total white 5%, lotus root 2%, underwear 2% juice, the remaining residue was bathed for 3 to 5 hours.

All of the powder, extract and juice were mixed and 10% honey was mixed well to prepare a gourd and put in porcelain.

In addition, the powder prepared above was put in a dryer, dried, and then ground to prepare a powder.

Preparation Example 3 Preparation of Pouch

Bellflower 2%, Ginseng 2%, Lioness 1%, Old Pan 1%, Angelica 3%, Baekchul 2%, Tangerine Blood 7%, Tosa 1%, Fresh Green Sulfur 2%, Schisandra 1%, Casualties 1%, Sewage 1%, Goji 2 %, Soybean 2%, Bokryeong 1%, Jujube 3%, Indong 1%, Buckwheat 1%, Total white 5%, Mugwort 2% Ginger 5%, Wool 1%, Sweet Ginseng 1%, Ginseng 1%, Seokchangpo 2% Peony 4 %, Shiraza 2%, Lotus root 2%, 칡 2%, Licorice 5%, Turmeric 1%, Green Ginseng 1%, Gardenia 1%, Honey 10%, Sasam 2%, Cinnamon 1%, Aloe ash 2%, Safflower 2 Wash%, underwear 2%, deodeok 2%, Okmok calligraphy 2%, crude 2%, Astragalus 1%, weak buckwheat 1%, perilla 2%, sanjoin 1%, and 1% poisonous water with water, and put into extractor. After extraction for hours, the extracts were individually packaged.

In addition, the extract was concentrated and mixed with excipients to prepare tablets or pills.

Experimental Example: Improvement of male sexual function

Preparation of Laboratory Animals

Experimental animals were used SD rat (Sampaco Bio Korea Co., Ltd.) of the absence of specific pathogens (SPF). 45 males and 8 females were purchased and the females were allowed to acclimate to the new environment for 7 days and the males were allowed to adapt to the new environment for 24 days. At the same time, the general symptoms were observed and healthy animals were used for the test. It was. All animals were weighed upon receipt and group separation. Rats were reared freely with solid feed for experimental animals sterilized in a constant temperature and humidity room at a temperature of 22 ± 3 ℃, a relative humidity of 55 ± 15%, and an illuminance of 150 to 300 lux. At this time, the drinking ground water sterilized using microfilter and ultraviolet light was freely ingested using a water bottle.

The test groups were separated by randomization using the ranked weights and each individual was marked using the ear punch (marked by ear punch), the color pigmented marker, and the identification by the breeder identification card.

Estrous females were induced for mating with males. Females were mixed with ketamine (Yuhan Corporation) and lumpoon (Bay Korea) at a ratio of 4: 1, and then anesthetized by injecting 1ml / kg into the abdominal cavity, followed by Wayneforth HB (1980, Experimental and Surgical Techniques in the Rat). Both ovaries were removed by the After the ovary was removed, the incision was closed and disinfected with Povidin iodine solution. The recovery period was 14 days after surgery. Estrous was induced by subcutaneous administration of estrogen at 10 μg / kg 48 hours prior to cohabitation followed by subcutaneous administration of progesterone at a dose of 500 μg / dog 4 to 6 hours prior to cohabitation. The gestational age of the females was 9 weeks and that of the samples was 11 weeks.

Dosing of Samples to Male Rats

Diluting the gourd of Preparation Example 1 with water to prepare a sample (high 0.2g / ml), and forced oral administration using Sonde for 1 time / 1 day, 7 days / 1 week, 4 weeks, the dosage was Rats were administered at 3, 6, 18 ml / kg based on body weight. The composition of each test group and dosage is shown in Table 1. At this time, the dosage was based on about 2 times, 4 times, and 8 times the amount applied to humans because no side effects were observed in the 40ml / kg administration group as a result of the preliminary test. The control group was administered sterile water for injection instead of the sample.

group gender Animal count (mari) Animal Number Dosage amount (ml / kg) Dose (mg / kg) G1 male 10 1 to 10 18 0 G2 male 10 11 to 20 3 3,114 G3 male 10 21-30 6 6,228 G4 male 10 31-40 18 18,684

G1: Control group administered sterile water for injection

G2 to G4: sample administration group

Weight change and general symptoms

In order to observe the sexual enhancement effect of the sample, the test was performed to observe the sexual behavior of the males while repeatedly administering for 4 weeks. The general symptoms of the animals were observed and recorded every day, and when observed, they were administered 90 minutes before the observation of sexual behavior. Body weights were measured once a week after the start of dosing and at necropsy.

No abnormal symptoms or weight loss related to the administration of the liquid sample were observed during the period of administration of the sample, and there were no visually observable side effects (male: Tables 2a, 2b, 2c, 2d, and female: Table 3). One animal in G4 group (No. 38) and one animal in G3 group (No. 21), whose body weight was significantly reduced after 4 weeks of administration, were judged to be due to the administration error due to foreign body and lung changes in the chest cavity. .

Weight Changes in Male SD Rats in the Control Group Individual Weight (Gram) Control group G1: 0 mg / kg (18 ml / kg) Test Animal Number 1 week 2 weeks 3 weeks 4 weeks 5 weeks One 373.82 374.78 408.48 420.80 433.96 2 381.94 384.72 414.04 421.02 391.12 3 389.28 391.74 427.06 438.08 460.98 4 396.30 394.80 434.22 443.20 463.18 5 399.24 398.26 421.16 435.24 455.80 6 408.13 414.28 446.28 451.94 477.82 7 411.51 421.36 449.26 464.14 479.58 8 409.67 419.96 457.60 467.28 489.76 9 412.70 420.72 463.96 477.02 494.16 10 429.21 434.30 476.74 490.78 516.96 Average 401.18 405.49 439.88 450.95 466.33 Standard Deviation 16.443 19.237 22.563 23.535 35.037 Number of test animals 10 10 10 10 10

Body weight change of male SD rats in 3,114 mg / kg sample Individual Weight (Gram) Test Group G2 (Dose: 3,114 mg / kg (3 ml / kg)) Test Animal Number 1 week 2 weeks 3 weeks 4 weeks 5 weeks 11 372.79 375.82 405.46 410.64 426.42 12 386.35 386.90 418.16 428.36 457.86 13 391.82 396.30 424.20 434.28 453.28 14 395.66 392.36 422.24 426.16 441.12 15 400.27 413.58 434.44 454.96 482.18 16 403.55 416.46 461.24 471.78 492.88 17 409.71 420.28 458.72 465.64 484.52 18 418.63 411.66 440.22 454.34 474.04 19 417.07 424.50 463.26 474.38 492.40 20 422.08 420.96 468.12 474.28 494.98 Average 401.79 405.88 439.61 449.48 469.97 Standard Deviation 15.682 16.748 22.105 23.038 24.002 Number of test animals 10 10 10 10 10

Body weight change in male SD rats at 6,228 mg / kg Individual Weight (Gram) Test Group G3 (Dose: 6,228 mg / kg (3 ml / kg)) Test Animal Number 1 week 2 weeks 3 weeks 4 weeks 5 weeks 21 375.33 380.30 411.48 420.78 295.04 22 384.01 393.34 416.56 418.76 402.80 23 392.22 394.94 426.32 437.06 464.36 24 391.80 397.00 430.16 440.24 450.70 25 399.61 406.62 435.26 431.26 421.86 26 403.84 406.56 447.34 454.62 476.84 27 406.93 409.82 439.22 445.20 459.52 28 406.20 414.58 447.56 454.64 481.90 29 423.11 430.56 467.78 478.68 502.14 30 421.31 427.48 458.90 468.06 493.70 Average 400.44 406.12 438.06 444.93 444.89 Standard Deviation 15.201 15.554 17.864 19.440 60.950 Number of test animals 10 10 10 10 10

Body weight change in male SD rats at 18,684 mg / kg Individual Weight (Gram) Test Group G4 (Dose: 18,684 mg / kg (3 ml / kg)) Test Animal Number 1 week 2 weeks 3 weeks 4 weeks 5 weeks 31 382.23 393.72 412.88 424.22 442.34 32 379.22 386.70 408.88 415.66 430.40 33 390.79 400.94 434.36 437.62 459.70 34 392.50 390.36 419.48 428.84 457.54 35 393.89 397.14 433.44 442.00 458.92 36 398.86 406.46 437.72 449.18 468.16 37 406.54 401.88 418.72 434.18 456.58 38 406.28 414.62 D D D 39 420.35 422.30 455.22 468.54 491.56 40 419.77 429.44 460.16 471.86 494.30 Average 399.04 404.36 431.21 441.34 462.17 Standard Deviation 14.163 13.951 18.028 19.063 20.627 Number of test animals 10 10 9 9 9

* D: Death.

Weight Changes in Female SD Rats Individual weight (grams) Test Animal Number 1 week 2 weeks 3 weeks Estrogen Subcutaneous Administration Progesterone Subcutaneous Administration No treatment Estrogen Subcutaneous Administration Progesterone Subcutaneous Administration One 278.60 283.43 273.66 289.32 287.68 2 276.42 280.24 285.04 295.92 300.10 3 294.70 301.47 294.48 314.90 311.78 4 294.07 301.18 284.46 298.60 303.04 5 265.27 273.46 283.20 298.88 302.32 6 280.60 287.68 281.42 306.54 309.34 7 278.86 287.90 305.16 333.36 334.82 8 274.11 280.40 316.22 332.24 337.88 Average 280.33 286.97 290.46 308.72 310.87 Standard Deviation 9.865 9.979 14.030 16.659 17.298 Number of test animals 8 8 8 8 8

Weight Changes in Female SD Rats Test Animal Number 4 weeks 5 weeks No treatment Estrogen Subcutaneous Administration Progesterone Subcutaneous Administration One 289.40 299.18 299.56 2 303.92 308.68 305.42 3 318.74 330.50 326.92 4 303.50 311.98 307.30 5 310.20 321.32 319.36 6 312.80 333.96 333.32 7 343.84 352.08 351.66 8 341.32 362.78 359.00 Average 315.47 327.56 325.32 Standard Deviation 18.804 21.827 21.760  Number of test animals 8 8 8

Measurement of the first mating time

The initial mating time was measured for the test group administered with the sample and the control group administered with the control.

Two to four weeks after the start of the administration, the test substance was administered to the male rats, and 90 minutes later, the first mating behavior time was measured by living with a female that induced estrus. The surroundings were darkened with red indirect lighting, and cohabited using a 600 × 300 × 200 mm cross box, and video was observed. In addition, females were used five dogs per test group and arranged so that the females were evenly distributed in each test group. The results are shown in Tables 4A-4D and FIG. 1.

Observation on the start of sample administration showed no significant difference between the control and test groups. In the second observation (two weeks after the start of administration), there was little difference between the control group and the test group, and there was no significant difference compared to the start date of the sample administration. When observed at the end of administration (4 weeks after the start of administration), there was little difference between the control group and the test group. A shortening of the first mating behavior was observed (p <0.05).

Statistical treatment was compared with the control using the Student's t-test using the general statistical commercial program SPSS 10.1. In addition, the degree of improvement was examined by comparing the start date of administration with the end date of administration for each group. Significance was considered P <0.05. Animals with abnormal symptoms and dying or dying more than 100 seconds from the initial mating behavior were excluded from all data.

 Effects of Mating Behavior on Male SD Rats Within 5 Minutes of Sterile Distilled Water Control group G1 Test Animal Number When dosing 2 weeks after administration After 4 weeks of administration First mating act (seconds) Mating Insert (times) First mating act (seconds) Mating Insert (times) First mating act (seconds) Mating Insert (times) One - - - - - - - - - 2 16 7 0 10 7 0 53 8 0 3 38 7 0 37 8 0 16 5 0 4 35 3 0 61 5 0 37 6 0 5 15 21 0 95 4 0 22 11 0 6 22 11 0 17 6 One 11 14 0 7 34 7 0 13 8 0 23 9 0 8 6 8 0 65 5 0 43 6 0 9 77 5 0 30 7 0 10 5 0 10 24 7 0 7 6 0 6 3 0 Average 29.7 8.4 0.0 37.2 6.2 0.1 24.6 7.4 0.0 Standard Deviation 20.65 5.17 0.00 30.37 1.39 0.33 16.30 3.43 0.00 Number of test animals 9 9 9 9 9 9 9 9 9

-: No measurement.

Effect on mating behavior of male SD rats within 5 minutes of administration of sample (3,114 mg / kg) Test Group G2 (Dose: 3,114 mg / kg (3ml / kg)) Test Animal Number When dosing 2 weeks after administration After 4 weeks of administration First mating act (seconds) Mating Insert (times) First mating act (seconds) Mating Insert (times) First mating act (seconds) Mating Insert (times) 11 40 10 One 70 3 0 14 6 0 12 12 6 0 61 3 0 7 16 0 13 62 3 0 20 8 0 35 14 0 14 36 17 0 20 15 0 24 13 0 15 85 4 0 10 8 0 27 6 0 16 2 13 0 37 13 0 26 7 0 17 20 7 0 18 8 0 81 2 0 18 47 14 0 15 23 One 15 22 0 19 10 13 0 3 9 0 35 7 0 20 - - - - - - - - - Average 34.9 9.7 0.1 28.2 10.0 0.1 29.3 10.3 0.0 Standard Deviation 27.08 4.90 0.33 23.13 6.26 0.33 21.56 6.30 0.00 Number of test animals 9 9 9 9 9 9 9 9 9

-: No measurement.

Effect of male SD rats on mating behavior within 5 minutes of sample administration (6,228 mg / kg) Test group G3 (dosage: 6,228 mg / kg (6ml / kg)) Test Animal Number When dosing 2 weeks after administration After 4 weeks of administration First mating act (seconds) Mating Insert (times) First mating act (seconds) Mating Insert (times) First mating act (seconds) Mating Insert (times) 21 - - - - - - - - - 22 10 18 0 26 13 0 32 18 0 23 19 5 0 15 13 0 23 13 0 24 26 14 0 24 6 0 8 14 0 25 20 8 0 16 12 0 56 6 0 26 5 10 0 67 4 0 14 9 0 27 49 10 0 36 5 0 55 7 0 28 9 11 0 8 23 0 37 11 0 29 70 14 0 58 10 0 26 10 0 30 40 6 0 14 10 0 24 10 0 Average 27.6 10.7 0.0 29.3 10.7 0.0 30.6 10.9 0.0 Standard Deviation 21.54 4.15 0.00 20.61 5.74 0.00 16.55 3.69 0.00 Number of test animals 9 9 9 9 9 9

-: No measurement.

Effects of Mating Behavior on Male SD Rats Within 5 Minutes of Sample (18,684 mg / kg) Administration Test group G4 (dosage: 18,684 mg / kg (18ml / kg)) Test Animal Number When dosing 2 weeks after administration After 4 weeks of administration First mating act (seconds) Mating Insert (times) First mating act (seconds) Mating Insert (times) First mating act (seconds) Mating Insert (times) 31 28 11 0 44 10 0 13 12 0 32 19 7 0 30 17 0 18 10 0 33 33 8 One 9 13 0 6 9 0 34 46 4 0 39 13 2 54 7 0 35 21 8 0 69 3 0 18 10 0 36 46 9 One 55 4 0 19 9 0 37 60 15 3 44 15 One 25 16 0 38 D D D D D D D D D 39 43 11 0 45 15 0 20 18 0 40 - - - - - - - - - Average 37.0 9.1 0.6 41.9 11.3 0.4 21.6 11.4 0.0 Standard Deviation 14.16 3.27 1.06 17.55 5.20 0.74 14.21 3.78 0.00 Number of test animals 8 8 8 8 8 8 8 8 8

-: No measurement. D: death

Measurement of the desired number of mating actions

For 5 minutes, the desired number of mating behaviors was observed. There was no statistically significant difference in all groups at the start of administration, but after 2 weeks of administration, the number of mating behaviors increased significantly in the G3 and G4 groups compared to the control group (P <0.05). After 4 weeks, the G4 group showed statistically significant increase compared to the control group (p <0.05) (Table 4a, 4b, 4c, 4d, FIG. 2).

Measurement of Insertion Count

The insertion frequency of 5 minutes was measured. The number of insertions in each group was not significantly different in the control group and the G1, G2, and G3 groups for a total of 5 minutes, but a total of 8 observations were observed in the G4 group administered with the liquid sample of 18,684 mg / kg (Tables 4a, 4b, 4c, 4d, FIG. 3).

Measurement of Testosterone in the Blood

Four weeks after the start of the administration, the blood of the rats were collected, serum was separated, and the testosterone content was measured and shown in Table 5 and FIG. 4.

Blood testosterone content was higher in the control group than in the control group, and the G2 group was significantly higher than the control group (p <0.05). There was no dose correlation of blood testosterone content of the sample, but it can be seen that the blood testosterone content is increased by administering the sample.

Determination of Testosterone Content in Plasma of Male SD Rats 4 Weeks After Initiation Control: G1 Test Group G2 (Dose: 3,114 mg / kg (3 ml / kg)) Test animal number. Testosterone (ng / ml) Test Animal Number Testosterone (ng / ml) One - 11 43.50 2 15.60 12 49.80 3 40.40 13 23.80 4 17.25 14 62.70 5 26.60 15 62.60 6 75.00 16 68.70 7 20.90 17 60.40 8 43.60 18 35.20 9 21.10 19 66.20 10 6.69 20 - Average 29.68 Average 52.54 Standard Deviation 20.628 Standard Deviation 15.532 Number of test animals 9 Number of test animals 9

-: No measurement.

Determination of Testosterone Content in Plasma of Male SD Rats 4 Weeks After Initiation Test Group G3 (Dose: 6,228 mg / kg (6 ml / kg)) Test Group G4 (Dose: 18,684 mg / kg (18 ml / kg)) Test animal number. Testosterone (ng / ml) Test Animal Number Testosterone (ng / ml) 21 - 31 4.31 22 17.60 32 32.30 23 69.40 33 7.24 24 4.94 34 1.45 25 11.50 35 72.80 26 22.20 36 63.60 27 47.50 37 4.48 28 75.00 38 D 29 75.00 39 67.80 30 12.30 40 - Average 37.27 Average 31.75 Standard Deviation 29.434 Standard Deviation 31.656 Number of test animals 9 Number of test animals 8

-: No measurement. D: death

The composition of the present invention exhibits an excellent effect on improving sexual function without side effects, and thus protects and strengthens the human intestine, which has an excellent effect on preventing adult diseases, and has the effect of purifying the human body.

1 is a graph showing the shortening effect of the mating behavior regression time in SD rats (1st: test start date, 2nd: 2 weeks after administration 3rd: 4 weeks after administration, G1: control, G2: sample dose 3114mg / kg, G3: sample dose 6,228 mg / kg, G4: sample dose 18,684 mg / kg, a) P <0.05: significantly shortened test group compared to G1).

Figure 2 is a graph showing the increase in the number of desired mating behavior in SD rats (1st: test start date, 2nd: 2 weeks after administration, 3rd: 4 weeks after administration, G1: control group, G2: sample dose 3114mg / kg , G3: 6,228 mg / kg sample dose, G4: 18,684 mg / kg sample dose, b) P <0.05: test group significantly increased compared to G1).

3 is a graph showing the increase in the number of insertions during mating behavior (1st: test start date, 2nd: 2 weeks after administration, 3rd: 4 weeks after administration, G1: control group, G2: sample dose 3114 mg / kg, G3 : Sample dose 6,228 mg / kg, G4: Sample dose 18,684 mg / kg).

Figure 4 is a graph showing the effect of increasing the testosterone content of the male hormone blood in SD rats (G1: control, G2: sample dose 3114mg / kg, G3: sample dose 6,228mg / kg, G4: sample dose 18,684 mg / kg, b) P <0.05: significantly increased group compared to G1).

Claims (7)

delete delete delete delete 2% by weight of bellflower, 2% by weight of ginseng, 1% by weight of wild lion, 1% by weight of old mulberry, 3% by weight of Angelica, 2% by weight of white peach, 7% by weight of tangerine, 1% by weight of Tosa, 2% by weight of raw sulfur, 1% by weight of Schizandra chinensis, 1% by weight of casualties, 1% by weight of sewage, 2% by weight of wolfberry, 2% by weight of soybeans, 1% by weight of Bokryeong, 3% by weight of jujube, 1% by weight of copper, 1% by weight of buckwheat, 5% by weight of wormwood, 2% by weight of mugwort, 5% by weight ginger, 4% by weight peony, 1% by weight dew, 1% by weight salviae ginseng, 1% by weight ginseng, 2% by weight stone spear, 2% by weight syrup, 2% by weight lotus root, 2% by weight, licorice 5% by weight , 1% by weight of turmeric, 1% by weight of green tea, 1% by weight of gardenia, 10% by weight of honey, 2% by weight of ginseng, 1% by weight of cinnamon, 2% by weight of aloe ash, 2% by weight of safflower, A composition for improving male sexual function, comprising 2% by weight, 2% by weight of Okmok calligraphy, 1% by weight of Astragalus, 1% by weight of wild bran, 2% by weight of perilla, 1% by weight of Sanjoin, and 1% by weight of venom. 6. A composition according to claim 5 in the form of a solid, pouch, pill, powder, granule, tablet, capsule, extract, acupuncture or tincture. delete