CN104491263A

CN104491263A - Medicine capable of promoting blood circulation to remove blood stasis for esophagus cancer and preparation method of medicine

Info

Publication number: CN104491263A
Application number: CN201410760909.7A
Authority: CN
Inventors: 李菲
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-12-13
Filing date: 2014-12-13
Publication date: 2015-04-08

Abstract

The invention discloses a medicine capable of promoting blood circulation to remove blood stasis for an esophagus cancer and a preparation method of the medicine. The medicine is prepared from the following main raw materials in parts by weight: 6-10 parts of ruddle, 10-15 parts of flos caryophylli, 15-20 parts of szechwan chinaberry fruit, 9-18 parts of brucea javanica, 15-20 parts of nidus vespae, 10-20 parts of fructus livistonae, 15-30 parts of centipeda minima, 15-25 parts of pokeberry root, 2-5 parts of catharanthus roseus, 2-5 parts of sal ammoniac, 9-15 parts of hedyotis diffusa and 6-15 parts of drumfish swimming bladder. The medicine has the advantages of being relatively low in treatment cost, free of a wound, relatively short in curative time, and free of a side effect; and the pain of a patient is relieved.

Description

Esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament and preparation method

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament and preparation method thereof.

Background technology

Esophageal carcinoma is common digestive tract tumor, and the whole world about has 300,000 people to die from esophageal carcinoma every year.Its M & M various countries are widely different.China is one of esophageal carcinoma hotspot in the world, and every annual is died of illness about 150,000 people.Man is more than female, and age of onset is many more than 40 years old.The Crowds Distribute of esophageal carcinoma and age, sex, occupation, race, region, living environment, dietary life habits, genetic predisposition etc. have certain relation.Through the disease that existing survey data display esophageal carcinoma may be caused by many factors.The cause of disease proposed is as follows: 1. chemical cause of disease nitrosamine.This compounds and precursor distribution very wide, can in vivo, outer formation, carcinogenecity is strong.2. biological agent fungus.In the grain of some district occurred frequently, in the upper digestive tract of esophageal cancer patients or in the esophageal carcinoma specimen of excision, all can isolate multiple fungus, wherein some fungus has carcinogenesis.Some fungus can impel the formation of nitrosamine and precursor thereof, more promotes the generation of cancerous protuberance.3. lack some trace element.4. be deficient in vitamin.Be deficient in vitamin A, vitamin B2, vitamin C and animal proteinum, fresh vegetables, fruit Deficiency of Intake, is a common feature of esophageal carcinoma district occurred frequently.5. the factors such as cigarette, wine, heat food, hot drink, oral cavity be unclean.Long-term drink ardent spirits, hobby smoking, food is really up to the mark, overheated, it is too fast to take food, and causes that chronic stimulation, inflammation, wound or oral cavity are unclean, dental caries etc. all may be relevant with the generation of esophageal carcinoma.6. esophageal carcinoma inheritance susceptible factor.Clinical manifestation: 1. early symptom is often not obvious, but discomfort sensation in various degree may be had when swallowing thick and stiff food, comprise ingest food choking feeling, after breastbone, burn sample, acupuncture sample or tractive friction sample pain.Food by slow, and has stagnation sense or foreign body sensation.Stalk is choked to stagnate to feel and alleviate disappearance after being swallowed water.Heavy time light during symptom, make slow progress.2. the typical symptom of middle and advanced stage esophageal carcinoma is Progressive symmetric erythrokeratodermia acataposis, before this food of difficult dry pharynx, is semiliquid diet then, and last water and saliva can not be swallowed.Often telling mucoid expectorant, is the saliva of hypopharynx and the secretions of esophagus.Patient becomes thin gradually, dewater, unable.Lasting chest pain or backache are expressed as symptom in late period, and cancer has been invaded esophagus and organized outward.When cancerous protuberance blocks caused inflammation edema transient remission, or after part cancerous protuberance comes off, obstruction can temporarily alleviate, and constant error thinks that sb.'s illness took a favorable turn.If cancerous protuberance invades recurrent laryngeal nerve, hoarseness can be there is; If compressing cervical sympathetic ganglia, Horner syndrome can be produced; If intrusion trachea-bronchial epithelial cell, esophagus, trachea or bronchial fistula can be formed, acutely choke when occurring swallowing water or food and cough, and respiratory system infection occurs.Finally there is cachectic states.If there is the Organ relative weight such as liver, brain, the states such as jaundice, seroperitoneum, stupor can be there is.

The treatment of esophageal carcinoma divides surgical intervention, radiotherapy, chemotherapy and Syndrome Types of TCM treatment etc.1. operative treatment.Operation is treatment esophageal carcinoma prefered method.If systemic conditions is good, have good cardio-pulmonary function deposit, without obvious metastasis sign person, can consider operative treatment.Generally larger with the chance of cervical part of esophagus cancer length < 3 centimetres, breast epimere cancer length < 4 centimetres, breast hypomere cancer length < 5 centimetres excision.But also have tumor body not too greatly but with major organs, can not the person of excision as the close adhesion such as aorta, trachea.The removability not quite all right person of entire patient is estimated to larger scale cancer, first can adopt preoperation radiotherapy, operate again after tumor body reduces.Surgical contraindication: 1. systemic conditions is poor, in cachexia.Or have the infull person of severe cardiac, lung or Liver and kidney function.2. pathological changes invades scope greatly, has obviously outer invading and signs of perforation, such as, has occurred hoarseness or existing esophago-tracheal fistula person.3. existing metastasis person.2. X-ray therapy.1. radiation and operative Combination Therapy, can increase Resection Rate, also can improve long term survival rate.After preoperation radiotherapy, having a rest, it is comparatively suitable within 3 ~ 4 weeks, to perform an operation again.Do metal marker to excising the incomplete residual tumor place of organizing in art, generally 3 ~ 6 weeks after surgery start postoperation radiotherapy.2. simple X-ray therapy, is used for cervical part of esophagus, breast epimere esophageal carcinoma, and usually difficulty is large in the operation of this kind of patient, and complication is many, and curative effect is unsatisfied with; Also can be used for having surgical contraindication and the pathological changes time not long, patient still can tolerate radiotherapy person.3. chemotherapy.The Comprehensive Treatment adopting chemotherapy to combine with operative treatment or combine with radiotherapy, Chinese medicine, sometimes can improve curative effect, or make esophageal cancer patients remission, showed prolonged survival.But make regular check on hemogram and hepatic and renal function, and note drug reaction.Syndrome Types of TCM is treated: differentiation of symptoms and signs for classification of syndrome is treated.A point card about esophageal carcinoma is had nothing in common with each other, and establishment of the therapeutic methods and Applying Medicine is also thereupon different.But method for the treatment of total not from depressed liver-energy dispersing and QI regulating, sending down the abnormal ascending QI blood stasis dispelling, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, the body resistance strengthening and constitution consolidating, promote the production of body fluid moisturize, heat-clearing and toxic substances removing, anticancer analgetic, warming YANG and invigorating QI etc.1. Qi-stagnation type.Main symptom: the performance of early esophageal cancer, without obvious dysphagia, during only for swallowing in sense esophagus gear choke, foreign body sensation or causalgia, the heavy tight sense of the gloomy discomfort of breast and back, time hidden time heavy dysphagia sense.X-ray inspection is mainly the pathological changes of early esophageal cancer.Pale tongue is dim, thin white fur of tongue, stringy and thready pulse.Method for the treatment of: depressed liver-energy dispersing and QI regulating, warming YANG and invigorating QI, Fuzheng Yiliu.2. obstruct type of choking.Main symptom: symptom is simple, slight stalk is choked or dysphagia.X-ray inspection belongs to early more, mid-term medullary, fungoid esophageal carcinoma.The dim green grass or young crops of body of the tongue, yellow fur is white, stringy and thready pulse.Method for the treatment of: anticancer dispersing, regulating QI and lowering the adverseness, warming YANG and strengthening body resistance.3. blood stasis type.Main symptom: symptom is except dysphagia, and based on chest pain, and pain has surely, or companion's halitosis etc.During x-ray inspection mostly is, late period medullary, ulcer type esophageal carcinoma.Body of the tongue purple is dim, and lingual surface has petechia or ecchymosis, and sublingual vein anger is opened, yellowish fur, deep and hesitant pulse and tight.Method for the treatment of: blood circulation promoting and blood stasis dispelling, warming YANG and invigorating QI, inducing menstruation to relieve menalgia.4. phlegm-damp type.Main symptom: dysphagia, accumulation and obstruction of sputum, breast pharynx dysphagia, diaphragm rib distension, adverse flow of turbid QI, the dim green grass or young crops of body of the tongue, macroglossia, has tooth to print in week, the white thick greasy many Tianjin of tongue, and pulse condition is sliding thin.X-ray inspection mostly is medullary in late period, constrictive type esophageal carcinoma.Method for the treatment of: warming YANG and invigorating QI, invigorating the spleen to clear away damp pathogen, sending down the abnormal ascending QI blood stasis dispelling.5. cloudy withered sun declines.Main symptom: stadium is late, acataposis is bordering on and blocks, vomiting and nausea QI rising in reverse order, emaciated physique, shortness of breath and fatigue, and dysphoria with smothery sensation lip is dry, and large dry stool is as excrement, and body of the tongue is dim deep red, slight of stature, few weary Tianjin of tongue or no fur, also has the black dry and person of splitting of yellow fur, thready and rapid pulse or heavy carefully unable.Method for the treatment of: nourishing YIN and invigorating YANG, benefiting QI and nourishing blood.

Application publication number CN 102475865 A(application number 201010573465.8) Chinese patent literature disclose a kind of Stemona tuber anticancer tablet for esophagus cancer, formulated by Radix Notoginseng, potassium iodide, Semen Persicae, the Radix Stemonae, Radix Glycyrrhizae, Lignum Aquilariae Resinatum, Borneolum Syntheticum, Sal Ammoniacus.Application publication number CN 103417610 A(application number 201310295133.1) Chinese patent literature disclose a kind of Chinese medicine for the treatment of esophageal carcinoma, it is made up of the raw material of following weight portion: Sal Ammoniacus 17-19 part, Borax 65-85 part, Borneolum Syntheticum 25-45 part, Galla Turcica (Galla Helepensis) 80-100 part, Radix Glycyrrhizae 15-35 part.Application publication number CN 103417810 A(application number 201310295242.3) Chinese patent literature disclose a kind of Chinese medicine for the treatment of esophageal carcinoma, it is made up of the raw material of following weight portion: Haematitum 25-35 part, Herba Agrimoniae 12-25 part, Radix Angelicae Sinensis 5-15 part, Rhizoma Dioscoreae 10-20 part, Radix Trichosanthis 10-20 part, Radix Asparagi 10-20 part, Radix Glycyrrhizae 10-20 part.

Operative treatment by cancer resection, but can bring postoperative dysfunction sometimes, and occurs some new symptoms.In addition, expenses of surgical treatment is high and there is certain risk.Reaction after radiotherapy and rear something lost phenomenon are also obvious.Chemotherapy also has obvious impact to digestive tract and hemopoietic system.Radiotherapy, chemotherapy can produce many side effect again, bring very large misery to patient.All kinds of symptoms that cancer causes, after taking Chinese medicine, often can obtain the improvement of certain hour.As cancer itself also takes a turn for the better because taking Chinese medicine, then symptom often can obviously be alleviated, even disappear.But the process for the treatment of by Chinese herbs cancer is very very long process, such tumor, when slowly disappearing, is brought a lot of slight illness to torment to patient undoubtedly, is also unfavorable for the treatment that patient is long-term.

Summary of the invention

For the deficiencies in the prior art, the object of this invention is to provide a kind of esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament and preparation method thereof.Medical expense of the present invention is lower, hurtless measure, healing time are shorter, have no side effect, alleviate patient suffering.

Technical scheme of the present invention is:

Esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament, takes off the primary raw material medicine stating weight proportion and is prepared from: Haematitum 6-10, Flos Caryophylli 10-15, Fructus Toosendan 15-20, Fructus Bruceae 9-18, Nidus Vespae 15-20, Chinese fanpalm seed 10-20, Herba Centipedae 15-30, Radix Phytolaccae 15-25, Herba Catharanthi Rosei 2-5, Sal Ammoniacus 2-5, Herba Hedyotidis Diffusae 9-15, Shishou Air Bladder pseudosciaenae seu Acipenser 6-15.

Esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Haematitum 7-9, Flos Caryophylli 11-13, Fructus Toosendan 17-19, Fructus Bruceae 12-15, Nidus Vespae 16-18, Chinese fanpalm seed 14-17, Herba Centipedae 20-25, Radix Phytolaccae 18-22, Herba Catharanthi Rosei 2.5-4, Sal Ammoniacus 2.5-4, Herba Hedyotidis Diffusae 11-13, Shishou Air Bladder pseudosciaenae seu Acipenser 8-13.

Esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Haematitum 8, Flos Caryophylli 12, Fructus Toosendan 18, Fructus Bruceae 13, Nidus Vespae 17, Chinese fanpalm seed 15, Herba Centipedae 22, Radix Phytolaccae 20, Herba Catharanthi Rosei 3, Sal Ammoniacus 3, Herba Hedyotidis Diffusae 12, Shishou Air Bladder pseudosciaenae seu Acipenser 10.

Present invention also offers the preparation method above-mentioned esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament being made pharmaceutically acceptable decoction, pill, powder and thick paste agent.

The preparation method of described decoction is:

(1) wash Haematitum surface dirt with water, taking-up is dried, knock fritter, loads in crock, is placed in intense fire, burns to being popular in, and taking-up is placed on vinegar 2-5 two per jin in iron pan, and (preferred, taking-up is placed on vinegar 2.5-4 two per jin in iron pan; Be more preferably, take out and be placed on vinegar per jin 3 liang in iron pan), broken while hot, cool rear porphyrize, crosses 120-160 mesh sieve and (preferably, crosses 130-150 mesh sieve; Be more preferably, cross 140 mesh sieves);

(2) Sal Ammoniacus is picked decontamination, knock fritter, puts in boiling water and dissolves, and filters, removing residue, in impouring porcelain basin, with the evaporation of vinegar water proof, every 10 jin of Sal Ammoniacus vinegar 4-6 jin (preferred, every 10 jin of Sal Ammoniacus vinegar 4.5-5.5 jin; Be more preferably, every 10 jin of Sal Ammoniacus vinegar 5 jin), at any time the white that liquid level is separated out is floated frost and pull out, put in ceramic whiteware cylinder, dry, be ground into fine powder, cross 120-160 mesh sieve and (preferably, cross 130-150 mesh sieve; Be more preferably, cross 140 mesh sieves);

(3) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, cross 120-160 mesh sieve and (preferably, cross 130-150 mesh sieve; Be more preferably, cross 140 mesh sieves), put cold-bottling for subsequent use;

(4) by all the other the 7 taste crude drug removing impurity except Haematitum, Sal Ammoniacus, Shishou Air Bladder pseudosciaenae seu Acipenser, Flos Caryophylli and Herba Centipedae, clean, put into marmite, add water, amount of water is that doubly (preferred, amount of water is 6-7 times of 7 taste crude drug gross masses to the 5-8 of 7 taste crude drug gross masses; Be more preferably, amount of water is 6.5 times of 7 taste crude drug gross masses), first boil to boiling with big fire, rear turn of little fire decocts 1.1-2.1 hour, and (preferred, rear turn of little fire decocts 1.4-1.8 hour; Be more preferably, rear turn of little fire decocts 1.6 hours), leach medicinal liquid;

(5) Flos Caryophylli and Herba Centipedae being joined step (4) fills in the marmite of medicinal residues, adds water, and amount of water is that doubly (preferred, amount of water is 4-5 times of 9 taste medical material gross masses to the 3.5-6 of 9 taste medical material gross masses; Be more preferably, amount of water is 4.3 times of 9 taste crude drug gross masses), first boil to boiling with big fire, rear turn of little fire decocts 25-50 minute, and (preferred, rear turn of little fire decocts 30-45 minute; Be more preferably, rear turn of little fire decocts 38 minutes), leach medicinal liquid;

(6) step (4) and step (5) gained medicinal liquid are merged, then, step (1), step (2) and step (3) gained are added wherein, to obtain final product.

The preparation method of described pill is:

(1) wash Haematitum surface dirt with water, taking-up is dried, knock fritter, loads in crock, is placed in intense fire, burns to being popular in, and taking-up is placed on vinegar 2-5 two per jin in iron pan, and (preferred, taking-up is placed on vinegar 2.5-4 two per jin in iron pan; Be more preferably, take out and be placed on vinegar per jin 3 liang in iron pan), broken while hot, cool rear porphyrize, crosses 110-150 mesh sieve and (preferably, crosses 120-140 mesh sieve; Be more preferably, cross 130 mesh sieves);

(2) Sal Ammoniacus is picked decontamination, knock fritter, puts in boiling water and dissolves, and filters, removing residue, in impouring porcelain basin, with the evaporation of vinegar water proof, every 10 jin of Sal Ammoniacus vinegar 4-6 jin (preferred, every 10 jin of Sal Ammoniacus vinegar 4.5-5.5 jin; Be more preferably, every 10 jin of Sal Ammoniacus vinegar 5 jin), at any time the white that liquid level is separated out is floated frost and pull out, put in ceramic whiteware cylinder, dry, be ground into fine powder, cross 110-150 mesh sieve and (preferably, cross 120-140 mesh sieve; Be more preferably, cross 130 mesh sieves);

(3) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, cross 110-150 mesh sieve and (preferably, cross 120-140 mesh sieve; Be more preferably, cross 130 mesh sieves), put cold-bottling for subsequent use;

(4) all the other the 9 taste Chinese medicines except Haematitum, Sal Ammoniacus and Shishou Air Bladder pseudosciaenae seu Acipenser are removed impurity, porphyrize respectively, cross 110-150 mesh sieve and (preferably, cross 120-140 mesh sieve; Be more preferably, cross 130 mesh sieves);

(5) step (1), step (2), step (3) and step (4) gained fine powder are mixed, add water pill, heavy 0.25-0.7g(is preferred for every ball, the heavy 0.3-0.6g of every ball; Be more preferably, the heavy 0.5g of every ball), dry, to obtain final product.

The preparation method of described powder is:

(1) wash Haematitum surface dirt with water, taking-up is dried, knock fritter, loads in crock, is placed in intense fire, burns to being popular in, and taking-up is placed on vinegar 2-5 two per jin in iron pan, and (preferred, taking-up is placed on vinegar 2.5-4 two per jin in iron pan; Be more preferably, take out and be placed on vinegar per jin 3 liang in iron pan), broken while hot, cool rear porphyrize, crosses 130-170 mesh sieve and (preferably, crosses 140-160 mesh sieve; Be more preferably, cross 150 mesh sieves);

(2) Sal Ammoniacus is picked decontamination, knock fritter, puts in boiling water and dissolves, and filters, removing residue, in impouring porcelain basin, with the evaporation of vinegar water proof, every 10 jin of Sal Ammoniacus vinegar 4-6 jin (preferred, every 10 jin of Sal Ammoniacus vinegar 4.5-5.5 jin; Be more preferably, every 10 jin of Sal Ammoniacus vinegar 5 jin), at any time the white that liquid level is separated out is floated frost and pull out, put in ceramic whiteware cylinder, dry, be ground into fine powder, cross 130-170 mesh sieve and (preferably, cross 140-160 mesh sieve; Be more preferably, cross 150 mesh sieves);

(3) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, cross 130-170 mesh sieve and (preferably, cross 140-160 mesh sieve; Be more preferably, cross 150 mesh sieves), put cold-bottling for subsequent use;

(4) all the other the 9 taste Chinese medicines except Haematitum, Sal Ammoniacus and Shishou Air Bladder pseudosciaenae seu Acipenser are removed impurity, porphyrize respectively, cross 130-170 mesh sieve and (preferably, cross 140-160 mesh sieve; Be more preferably, cross 150 mesh sieves);

(5) step (1), step (2), step (3) and step (4) gained fine powder are mixed, sterile packaged, often wrap 4 grams.

The preparation method of described thick paste agent is:

(4) by all the other the 7 taste crude drug removing impurity except Haematitum, Sal Ammoniacus, Shishou Air Bladder pseudosciaenae seu Acipenser, Flos Caryophylli and Herba Centipedae, clean, put into marmite, add water, amount of water is that doubly (preferred, amount of water is 6-7.5 times of 7 taste crude drug gross masses to the 5.5-8.5 of 7 taste crude drug gross masses; Be more preferably, amount of water is 7 times of 7 taste crude drug gross masses), first boil to boiling with big fire, rear turn of little fire decocts 1.3-2.3 hour, and (preferred, rear turn of little fire decocts 1.6-2 hour; Be more preferably, rear turn of little fire decocts 1.8 hours), leach medicinal liquid;

(5) Flos Caryophylli and Herba Centipedae being joined step (4) fills in the marmite of medicinal residues, adds water, and amount of water is that doubly (preferred, amount of water is 4-5 times of 9 taste crude drug gross masses to the 3.5-6 of 9 taste crude drug gross masses; Be more preferably, amount of water is 4.3 times of 9 taste crude drug gross masses), first boil to boiling with big fire, rear turn of little fire decocts 30-50 minute, and (preferred, rear turn of little fire decocts 35-45 minute; Be more preferably, rear turn of little fire decocts 40 minutes), leach medicinal liquid;

(6) step (4) and step (5) gained medicinal liquid are merged, decompression, be concentrated into the thick paste that relative density is 1.32-1.42 and (preferably, be concentrated into the thick paste that relative density is 1.35-1.39; Be more preferably, be concentrated into the thick paste that relative density is 1.37), then add refined honey, it is preferred that every 100kg thick paste adds refined honey 125-150kg(, and every 100kg thick paste adds refined honey 135-145kg; Be more preferably, every 100kg thick paste adds refined honey 140kg, then step (1), step (2) and step (3) gained fine powder is added and mix well, micro-refining, foam removal, seals and get final product in dress aseptic bottle.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Haematitum: having another name called palpus ball, red soil, fourth head Haematitum, blood teacher, purple Zhu, Haematitum, native Zhu, ferrum Zhu, ailhead Haematitum, nail Haematitum, red Haematitum, red stone, Haematitum, is the Ore of oxide-based mineral bloodstone.Main component: mainly containing iron sesquioxide, also containing a small amount of titanium, magnesium, aluminum, manganese, calcium, silicon and moisture.The property of medicine: bitter, sweet, flat.Return liver, stomach, pericardium channel.Function cures mainly: suppressing the hyperactive liver town is inverse, cooling blood for hemostasis.Control eructation vomiting, dysphagia and regurgitation, asthma, infantile convulsion, spit blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, bleeding not during menses.

Flos Caryophylli: another name: hundred knots, feelings visitor, Syringa oblata Lindl., sub-Flos Caryophylli, clove tree, dismemberent perfume, male Flos Caryophylli, Flos Caryophylli.Base is former: be the alabastrum of dicotyledon medicine plant clove of myrtaceae.The property of medicine: pungent, temperature.Return spleen, stomach, lung, kidney channel.Function cures mainly: warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For Deficiency and coldness of spleen and stomach, singultus is vomitted, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.

Fructus Toosendan: base is former: be the fruit of canella Fructus Toosendan.Chemical analysis: containing Toosendanin, alkaloid, kaempferol, resin, tannin.The property of medicine: bitter, cold, poisonous.Return liver, stomach, small intestine meridian.Function cures mainly: except damp and hot, clearing away liver-fire, pain relieving, parasite killing.Control epigastric pain with cold limbs due to adverseness of heat, hypochondriac pain, colic, abdominal pain due to worm stagnation.

Fructus Bruceae: base is former: be the fruit of quassia Fructus Bruceae.Chemical analysis: Fructus Bruceae claims bruceolic acid etc. containing alkaloid (brucamarine and yatanine etc.), glucoside (brucealin, brucealin etc.), phenolic constituent (brucenol etc.) and a kind of hydroxy carboxylic acid.The fatty oil of java brucea seed (Oleum Fructus Bruceae) 56.23%.In oil, non-saponifiable matter accounts for 1.36%, includes volatile oil a little; Saponified 92.47%, include oleic acid (same under accounting for the % of crude oil) 81.87%, linoleic acid 3.37%, stearic acid 2.65%, Palmic acid 6.62% etc.; Fusing point is the spun silk shape crystalline solid 4.59% of 152 DEG C in addition.Containing the bitter principle of similar guassin on various structures in seed: Brusatol, bruceine A, B, C, D, E, F, G, H etc.The property of medicine: bitter, cold, poisonous.Function cures mainly: heat clearing away, dampness, parasite killing, removing toxic substances.Control dysentery, chronic diarrhea, malaria, hemorrhoid, furunculosis, wart, clavus.

Nidus Vespae: base is former: be the nest of Vespidae insecticide yellow star long foot wasp or multiple nearly edge insecticide.Chemical analysis: Hornet nest is oily containing dew room, Cera Flava, resin, various saccharides, vitamin and inorganic salt etc.The property of medicine: micro-sweet, flat, mild toxicity.Return liver, stomach, kidney channel.Function cures mainly: the detumescence of wind-expelling pain-stopping, rose poison, killing parasites for relieving itching.Main air temperature arthralgia pain, wind carious pain, carbuncle malignant boil, scrofula, mouthpiece swell and ache, anal fistula, rubella pruritus, skin stubborn dermatitis.

Chinese fanpalm seed: another name seed of Livistona chinensis R.Br..Base is former: be the seed of babassu Semen livistonae chinensis.Chemical analysis: seed contains phenols, reducing sugar, tannin, triacylglycerol, aminoacid: lysine, serine, arginine, proline, tyrosine, valine, isoleucine, phenylalanine, sugar, vitamin C and ascorbic acid.The oil of shell and kernel is mainly containing oleic acid.The property of medicine: sweet, bitter, flat, mild toxicity.Function cures mainly: blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.Main chronic hepatitis, lump in the abdomen.

Herba Centipedae: base is former: be the wounded in the battle herb of feverfew Myriogyne minuta.Chemical analysis: still contain stigmasterol, sitosterol, flavonoid, volatile oil, organic acid etc. containing multiple Triterpenoid, taraxerol, taraxasterol, arnidiol and another kind of three unknown terpinums in herb.The property of medicine: pungent, temperature." must book on Chinese herbal medicine be joined ": " enter meridian of Hand-TAI YIN edema caused by disorder of QI." function cures mainly: dispel the wind, cold expelling, victory is wet, removing nebula, stuffy nose relieving plug.Cure cold, asthma of cold-type, sore throat, pertussis, eruptive disease is suffered from abdominal pain, and amebic dysentery, malaria, infantile malnutrition with diarrhea, nasal sinusitis, nasal polyp, corneal nebula is puckery itches, ecthyma, scabies, traumatic injury.

Radix Phytolaccae: base is former: be the root of Phytolaccaceae plant pokeweed.Chemical analysis: containing phytolaccine, volume potassium nitrate, Saponin.The property of medicine: bitter, cold, poisonous.Enter spleen, urinary bladder channel.Function cures mainly: logical two just, removing water retention by purgation, eliminating stagnation.Harness the river swollen, distension, beriberi, sore throat, carbuncle, malignant boil.

Herba Catharanthi Rosei: base is former: be Apocynaceae periwinkle plant Herba Catharanthi Rosei, the herb of yellow Herba Catharanthi Rosei.Composition: plant containing indoles alkaloid more than 70 in Herba Catharanthi Rosei, comprise vinblastine, vincristine, lochnericine, lochnericine, remove acetyl vindorosine, vincaleucoblastine, Changchun Buddhist nun is fixed, lochnerinine etc.Root containing alkaloid, comprises that 9-methoxycorynantheidine., akuammicine, west, Changchun are fixed, lochnerivine, cavineine sulfate, sulphuric acid stay around western language alkali, and ammocalline, sulphuric acid group is around raw etc.Pharmacology: 1. antitumor action.The vinblastine that Herba Catharanthi Rosei contains, vincristine, leurosine, leurosidine have obvious antitumor action.2. Antitumor Mechanism.Herba Catharanthi Rosei antitumor action is directly relevant to the high-affinity of tubulin binding with medicine, suppress nucleic acid synthesis be it another mechanism.3. blood pressure lowering and vasodilative effect.No matter catharanthus roseus total alkaloids gavage, intramuscular injection or quiet note all have hypotensive effect to anesthetized dog, also has the effect of expansion coronary vasodilator.4. blood sugar lowering and effect for reducing blood fat.The water extract of this product leaf has normal or alloxan diabetes rabbit and dog and reduces blood glucose effect.The property of medicine: bitter, cold, poisonous.Function cures mainly: detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver.Cure mainly multiple cancerous protuberance, hypertension, carbuncle sore tumefacting virus, scald.

Sal Ammoniacus: base is former: be the crystal of halogenide class mineral Sal Ammoniacus.Chemical analysis: the main containing ammonium chloride of SALMIACUM.The property of medicine: the property of medicine: salty, bitter, pungent, temperature, poisonous.Return liver, spleen, stomach warp.Function cures mainly: removing food stagnancy softening the hard mass, drastically removing blood stasis and resolving static blood.Control lump in the abdomen Xuan tinea, dysphagia and regurgitation, phlegm retention, sore throat, long-pending dysentery, amenorrhea, corneal nebula, polyp, warty vegetation, furuncle, scrofula, carbuncle, malignant boil.

Herba Hedyotidis Diffusae: base is former: be the whole herb with root of Radix Rubiae kind of plant Herba Hedyotidis Diffusae.Chemical analysis: separate 1 alkane, stigmasterol, ursolic acid, oleanolic acid in herb, cupreol, cupreol-D-Glucose glycoside, P-coumaric acid etc.

The property of medicine: bitter, sweet, cold." Guangxi Chinese medicinal herbal ": " entering the heart, liver, spleen three warp " function cures mainly: heat clearing away, dampness removing, removing toxic substances.Control dyspnea and cough due to lung-heat, tonsillitis.Pharyngolaryngitis, appendicitis, dysentery, urinary tract infection, jaundice, hepatitis, pelvic inflammatory disease, adnexitis, carbuncle furuncle, venom, tumor.Also can be used for alimentary tract cancer.

Shishou Air Bladder pseudosciaenae seu Acipenser: base is former: be the Air Bladder pseudosciaenae seu Acipenser of Sciaenidae animal Carnis Pseudosciaenae or Carnis Pseudosciaenae.The property of medicine: sweet, flat.Return kidney, Liver Channel.Function cures mainly: the kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, dissipating blood stasis, detumescence.Control spermatorrhea of suffering from a deficiency of the kidney, puerperal puerperal tetanus, tetanus, spit blood, metrorrhagia, wound hemorrhage, hemorrhoid.

Esophageal carcinoma blood circulation promoting and blood stasis dispelling reagent combination provided by the invention is scientific and reasonable, products obtained therefrom taking convenience.In addition, excellent results of the present invention also shows:

1, do not perform the operation, not radiotherapy, not chemotherapy, not to be in hospital, hurtless measure, has no side effect, and patient easily accepts;

2, medical expense is lower, can alleviate the financial burden of patient;

3, healing time is shorter, alleviates patient suffering;

4, there is blood circulation promoting and blood stasis dispelling, detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver, reducing swelling and alleviating pain, removing food stagnancy softening the hard mass, drastically removing blood stasis and resolving static blood, the kidney invigorating and essence nourishing

Etc. effect, there is good curative effect for esophageal carcinoma;

5, by the diagnosis and prescription that the traditional Chinese medical science is traditional, strengthen antitumaous effect, strengthen immunologic function, prevent recurrence and transfer, life quality and the survival rate of patient can be significantly improved.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

embodiment 1esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament, the primary raw material medicine getting following weight parts is prepared from (every part is 25g): Haematitum 6 parts, Flos Caryophylli 10 parts, Fructus Toosendan 15 parts, Fructus Bruceae 9 parts, Nidus Vespae 15 parts, Chinese fanpalm seed 10 parts, Herba Centipedae 15 parts, Radix Phytolaccae 15 parts, Herba Catharanthi Rosei 2 parts, Sal Ammoniacus 2 parts, Herba Hedyotidis Diffusae 9 parts, 6 parts, Shishou Air Bladder pseudosciaenae seu Acipenser.

The preparation method of above-mentioned esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament decoction is:

(1) wash Haematitum surface dirt with water, taking-up is dried, knock fritter, loads in crock, is placed in intense fire, burns to being popular in, and takes out and is placed on vinegar per jin 2 liang in iron pan, broken while hot, and cool rear porphyrize crosses 120 mesh sieves;

(2) Sal Ammoniacus is picked decontamination, knock fritter, puts in boiling water and dissolves, and filters, removing residue, in impouring porcelain basin, with the evaporation of vinegar water proof, every 10 jin of Sal Ammoniacus vinegar 4 jin, float frost by the white that liquid level is separated out at any time and pull out, put in ceramic whiteware cylinder, dry, be ground into fine powder, cross 120 mesh sieves;

(3) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, cross 120 mesh sieves, put cold-bottling for subsequent use;

(4) by all the other the 7 taste crude drug removing impurity except Haematitum, Sal Ammoniacus, Shishou Air Bladder pseudosciaenae seu Acipenser, Flos Caryophylli and Herba Centipedae, clean, put into marmite, add water, amount of water is 5 times of 7 taste crude drug gross masses, first boils to boiling with big fire, rear turn of little fire decocts 1.1 hours, leaches medicinal liquid;

(5) Flos Caryophylli and Herba Centipedae being joined step (4) fills in the marmite of medicinal residues, adds water, and amount of water is 3.5 times of 9 taste medical material gross masses, first boils to boiling with big fire, and rear turn of little fire decocts 25 minutes, leaches medicinal liquid;

Esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament decoction instructions of taking of the present invention: every day twice, each 250mL(is warm).

embodiment 2esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament, the primary raw material medicine getting following weight parts is prepared from (every part is 25g): Haematitum 6-10 part, Flos Caryophylli 15 parts, Fructus Toosendan 20 parts, Fructus Bruceae 18 parts, Nidus Vespae 20 parts, Chinese fanpalm seed 20 parts, Herba Centipedae 30 parts, Radix Phytolaccae 25 parts, Herba Catharanthi Rosei 5 parts, Sal Ammoniacus 5 parts, Herba Hedyotidis Diffusae 15 parts, 15 parts, Shishou Air Bladder pseudosciaenae seu Acipenser.

The preparation method of above-mentioned esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament pill is:

(1) wash Haematitum surface dirt with water, taking-up is dried, knock fritter, loads in crock, is placed in intense fire, burns to being popular in, and takes out and is placed on vinegar per jin 3 liang in iron pan, broken while hot, and cool rear porphyrize crosses 130 mesh sieves;

(2) Sal Ammoniacus is picked decontamination, knock fritter, puts in boiling water and dissolves, and filters, removing residue, in impouring porcelain basin, with the evaporation of vinegar water proof, every 10 jin of Sal Ammoniacus vinegar 5 jin, float frost by the white that liquid level is separated out at any time and pull out, put in ceramic whiteware cylinder, dry, be ground into fine powder, 130 mesh sieves;

(3) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, cross 130 mesh sieves, put cold-bottling for subsequent use;

(4) all the other the 9 taste Chinese medicines except Haematitum, Sal Ammoniacus and Shishou Air Bladder pseudosciaenae seu Acipenser are removed impurity, porphyrize respectively, crosses 130 mesh sieves;

(5) step (1), step (2), step (3) and step (4) gained fine powder are mixed, add water pill, the heavy 0.5g of every ball, dry, to obtain final product.

model case one:king XX, female, 60 years old.Main suit: dysphagia companion gastral cavilty portion pain twinge 6 months.History of present illness: before 6 months, patient occurs dysphagia without obvious inducement, and diseases caused by retention of fluid is feasible, under paddy food difficulty, be hard and dry hard as sheep dung, skin is uninteresting, chokes with sobs.Body of the tongue purple is dim, and lingual surface has ecchymosis, yellow fur, white thick greasy, and pulse condition is carefully puckery.Be diagnosed as esophageal carcinoma.Carry out 1 course for the treatment of (23 times) radiotherapy afterwards in hospital, only can enter plastic flow food, weight loss more than 10 jin when leaving hospital, and in a wheat harvesting period after leaving hospital, the difficulty that repeatedly occurs dripping enters the phenomenon of esophagus irritation, always by transfusion maintenance.Take the present embodiment gained esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament pill, every day three times, each 10 balls.Take two weeks and can eat half bowl of rice, pain relief.Take and can eat half block steamed bun in 1 month.After taking medicine 3 months, health and ordinary person are as good as.

embodiment 3esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament, the primary raw material medicine getting following weight parts is prepared from (every part is 25g): Haematitum 7 parts, Flos Caryophylli 11 parts, Fructus Toosendan 17 parts, Fructus Bruceae 12 parts, Nidus Vespae 16 parts, Chinese fanpalm seed 14 parts, Herba Centipedae 20 parts, Radix Phytolaccae 18 parts, Herba Catharanthi Rosei 2.5 parts, Sal Ammoniacus 2.5 parts, Herba Hedyotidis Diffusae 11 parts, 8 parts, Shishou Air Bladder pseudosciaenae seu Acipenser.

The preparation method of above-mentioned esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament powder is:

(1) wash Haematitum surface dirt with water, taking-up is dried, knock fritter, loads in crock, is placed in intense fire, burns to being popular in, and takes out and is placed on vinegar per jin 3 liang in iron pan, broken while hot, and cool rear porphyrize crosses 150 mesh sieves;

(2) Sal Ammoniacus is picked decontamination, knock fritter, puts in boiling water and dissolves, and filters, removing residue, in impouring porcelain basin, with the evaporation of vinegar water proof, every 10 jin of Sal Ammoniacus vinegar 5 jin, float frost by the white that liquid level is separated out at any time and pull out, put in ceramic whiteware cylinder, dry, be ground into fine powder, cross 150 mesh sieves;

(3) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, cross 150 mesh sieves, put cold-bottling for subsequent use;

(4) all the other the 9 taste Chinese medicines except Haematitum, Sal Ammoniacus and Shishou Air Bladder pseudosciaenae seu Acipenser are removed impurity, porphyrize respectively, crosses 150 mesh sieves;

model case two:normal XX, man, 55 years old.Main suit: more than Progressive symmetric erythrokeratodermia dysphagia March.History of present illness: patient was begun to feel and slightly to be choked with sobs sense after feed before March, because of symptom slightly and intermittently occur, therefore to treat.Rear symptom comparatively before obviously increase the weight of, occurrence number also increases, and becomes thin, and does not give Drug therapy, and symptom also has no improvement.Enter general food also to send out and choke, burn feeling after companion's breastbone, but enter semi-fluid sense of food and feel not obvious, be diagnosed as esophageal carcinoma.Take the present embodiment gained esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament powder, every day twice, each 4 grams, warm boiled water.Take 10 days, after breastbone, burn feeling alleviates.After taking 1 month, after breastbone, burn feeling disappears, and has a meal occasionally to have to send out and chokes.Continue to take two months, disease disappears, and diet is unimpeded, without uncomfortable.Follow up a case by regular visits to and do not recur so far.

embodiment 4esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament, the primary raw material medicine getting following weight parts is prepared from (every part is 25g): Haematitum 9 parts, Flos Caryophylli 13 parts, Fructus Toosendan 19 parts, Fructus Bruceae 15 parts, Nidus Vespae 18 parts, Chinese fanpalm seed 17 parts, Herba Centipedae 25 parts, Radix Phytolaccae 22 parts, Herba Catharanthi Rosei 4 parts, Sal Ammoniacus 4 parts, Herba Hedyotidis Diffusae 13 parts, 13 parts, Shishou Air Bladder pseudosciaenae seu Acipenser.

The preparation method of above-mentioned esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament thick paste agent is:

(1) wash Haematitum surface dirt with water, taking-up is dried, knock fritter, loads in crock, is placed in intense fire, burns to being popular in, and takes out and is placed on vinegar per jin 3 liang in iron pan, broken while hot, and cool rear porphyrize crosses 140 mesh sieves;

(2) Sal Ammoniacus is picked decontamination, knock fritter, puts in boiling water and dissolves, and filters, removing residue, in impouring porcelain basin, with the evaporation of vinegar water proof, every 10 jin of Sal Ammoniacus vinegar 5 jin, float frost by the white that liquid level is separated out at any time and pull out, put in ceramic whiteware cylinder, dry, be ground into fine powder, cross 140 mesh sieves;

(3) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, be pressed into powder, cross 140 mesh sieves, put cold-bottling for subsequent use;

(4) by all the other the 7 taste crude drug removing impurity except Haematitum, Sal Ammoniacus, Shishou Air Bladder pseudosciaenae seu Acipenser, Flos Caryophylli and Herba Centipedae, clean, put into marmite, add water, amount of water is 7 times of 7 taste crude drug gross masses, first boils to boiling with big fire, rear turn of little fire decocts 1.8 hours, leaches medicinal liquid;

(5) Flos Caryophylli and Herba Centipedae being joined step (4) fills in the marmite of medicinal residues, adds water, and amount of water is 4.3 times of 9 taste crude drug gross masses, first boils to boiling with big fire, and rear turn of little fire decocts 40 minutes, leaches medicinal liquid;

(6) step (4) and step (5) gained medicinal liquid are merged, decompression, be concentrated into the thick paste that relative density is 1.37, then refined honey is added, every 100kg thick paste adds refined honey 140kg, then step (1), step (2) and step (3) gained fine powder is added and mix well, micro-refining, foam removal, seals and get final product in dress aseptic bottle.

model case three:grandson XX, man, 52 years old.Main suit's dysphagia, based on chest pain.Health is fine usually, and flu all seldom has, but nearly two months have had a hunch that thing is stuck on esophagus, sometimes inadvertently swallow saliva, also can feel chest pain.Hospital diagnosis is gone to be esophageal carcinoma.Take the agent of the present embodiment gained esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament thick paste, every day three times, each 20 grams.Take two weeks, chest pain symptom alleviates.Continue to take 2 months, all diseases disappear, and go to hospital to do every inspection normal.

embodiment 5esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament, the primary raw material medicine getting following weight parts is prepared from (every part is 25g): Haematitum 8 parts, Flos Caryophylli 12 parts, Fructus Toosendan 18 parts, Fructus Bruceae 13 parts, Nidus Vespae 17 parts, Chinese fanpalm seed 15 parts, Herba Centipedae 22 parts, Radix Phytolaccae 20 parts, Herba Catharanthi Rosei 3 parts, Sal Ammoniacus 3 parts, Herba Hedyotidis Diffusae 12 parts, 10 parts, Shishou Air Bladder pseudosciaenae seu Acipenser.

(4) by all the other the 7 taste crude drug removing impurity except Haematitum, Sal Ammoniacus, Shishou Air Bladder pseudosciaenae seu Acipenser, Flos Caryophylli and Herba Centipedae, clean, put into marmite, add water, amount of water is 6.5 times of 7 taste crude drug gross masses, first boils to boiling with big fire, rear turn of little fire decocts 1.6 hours, leaches medicinal liquid;

(5) Flos Caryophylli and Herba Centipedae being joined step (4) fills in the marmite of medicinal residues, adds water, and amount of water is 4.3 times of 9 taste medical material gross masses, first boils to boiling with big fire, and rear turn of little fire decocts 38 minutes, leaches medicinal liquid;

test example 1the clinical practice of embodiment 5 esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament decoction: in June ,-2012 in April, 2010,232 routine esophageal cancer patients are screened in 8 hospitals, wherein male 132 example, women 100 example, oldest 74 years old, minimum 39 years old of age, 55 years old mean age, the course of disease 2 months-8 months, average 4 months.Be divided into two groups at random, experimental group and matched group (often organizing 116 people).Experimental group is male 66 example wherein, women 50 example, oldest 74 years old, minimum 39 years old of age, 55 years old mean age, the course of disease 2 months-8 months, average 4 months.Matched group male 66 example, women 50 example, oldest 74 years old, minimum 39 years old of age, 55 years old mean age, the course of disease 2 months-8 months, average 4 months.The relatively general clinical data of two groups of patients, difference has statistical significance (P > 0.05), can analyze contrast.Experimental group uses the present embodiment 5 products obtained therefrom, and every day twice, each 250mL(is warm).Matched group uses the medicine of conventional therapy esophageal carcinoma (as oxaliplatin fluorouracil, esophagus flat loose, anticancer pill ball, cinobufacin oral liquid etc.).Curative effect judging standard: cure: clinical symptoms all disappears, electronic gastroscopy and check pathological section result all normal; Effective: all or part of disappearance of clinical symptoms or electronic gastroscope show that cancerous protuberance has the change reduced; Invalid: clinical symptoms and inspection have no significant change.Total effectively comprising cures and effective.Treat after five months, result is as shown in table 1.

Table 1: embodiment 5 gained esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament decoction compliance test result [example (%)]

Therapeutic effect: cure 76 examples (65.52%), effective 38 examples (32.76%), invalid 2 examples (1.72%), total effective rate 98.28%.Successful is better than matched group.

The present invention selects Haematitum, Flos Caryophylli, Fructus Toosendan and Fructus Bruceae etc. to carry out compatibility, makes esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament.In side, Haematitum suppressing the hyperactive liver town is inverse, cooling blood for hemostasis.Flos Caryophylli warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.Fructus Toosendan removes damp and hot, clearing away liver-fire, pain relieving, parasite killing.Fructus Bruceae heat clearing away, dampness, parasite killing, removing toxic substances.The detumescence of Nidus Vespae wind-expelling pain-stopping, rose poison, killing parasites for relieving itching.Chinese fanpalm seed blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.Herba Centipedae is dispeled the wind, cold expelling, and victory is wet, removing nebula, stuffy nose relieving plug.Radix Phytolaccae leads to two just, removing water retention by purgation, eliminating stagnation.Herba Catharanthi Rosei detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver.Sal Ammoniacus removing food stagnancy softening the hard mass, drastically removing blood stasis and resolving static blood.Herba Hedyotidis Diffusae heat clearing away, dampness removing, removing toxic substances.Carnis Pseudosciaenae Air Bladder pseudosciaenae seu Acipenser has the kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, scattered silt, the effect of detumescence.All medicines share, and have blood circulation promoting and blood stasis dispelling, detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver, reducing swelling and alleviating pain, removing food stagnancy softening the hard mass, and the effect such as drastically removing blood stasis and resolving static blood, the kidney invigorating and essence nourishing, has good curative effect for esophageal carcinoma.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Haematitum 6-10, Flos Caryophylli 10-15, Fructus Toosendan 15-20, Fructus Bruceae 9-18, Nidus Vespae 15-20, Chinese fanpalm seed 10-20, Herba Centipedae 15-30, Radix Phytolaccae 15-25, Herba Catharanthi Rosei 2-5, Sal Ammoniacus 2-5, Herba Hedyotidis Diffusae 9-15, Shishou Air Bladder pseudosciaenae seu Acipenser 6-15.

2. esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament according to claim 1, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Haematitum 7-9, Flos Caryophylli 11-13, Fructus Toosendan 17-19, Fructus Bruceae 12-15, Nidus Vespae 16-18, Chinese fanpalm seed 14-17, Herba Centipedae 20-25, Radix Phytolaccae 18-22, Herba Catharanthi Rosei 2.5-4, Sal Ammoniacus 2.5-4, Herba Hedyotidis Diffusae 11-13, Shishou Air Bladder pseudosciaenae seu Acipenser 8-13.

3. esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament according to claim 1, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Haematitum 8, Flos Caryophylli 12, Fructus Toosendan 18, Fructus Bruceae 13, Nidus Vespae 17, Chinese fanpalm seed 15, Herba Centipedae 22, Radix Phytolaccae 20, Herba Catharanthi Rosei 3, Sal Ammoniacus 3, Herba Hedyotidis Diffusae 12, Shishou Air Bladder pseudosciaenae seu Acipenser 10.

4., according to the arbitrary described esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament of claim 1-3, it is characterized in that, this esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament is made decoction, and the preparation method of described decoction is:

5., according to the arbitrary described esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament of claim 1-3, it is characterized in that, this esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament is made pill, and the preparation method of described pill is:

6., according to the arbitrary described esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament of claim 1-3, it is characterized in that, this esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament is made powder, and the preparation method of described powder is:

7., according to the arbitrary described esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament of claim 1-3, it is characterized in that, this esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament is made thick paste agent, and the preparation method of described thick paste agent is:

(1) wash Haematitum surface dirt with water, taking-up is dried, knock fritter, loads in crock, being placed in intense fire, burning to being popular in, take out and be placed on vinegar 2-5 two per jin in iron pan, broken while hot, cool rear porphyrize, crosses 120-160 mesh sieve and (preferably, crosses 130-150 mesh sieve; Be more preferably, cross 140 mesh sieves);

(2) Sal Ammoniacus is picked decontamination, knock fritter, puts in boiling water and dissolves, filter, removing residue, in impouring porcelain basin, evaporate with vinegar water proof, every 10 jin of Sal Ammoniacus vinegar 4-6 jin, float frost by the white that liquid level is separated out at any time and pull out, put in ceramic whiteware cylinder, dry, be ground into fine powder, cross 120-160 mesh sieve and (preferably, cross 130-150 mesh sieve; Be more preferably, cross 140 mesh sieves);

(6) step (4) and step (5) gained medicinal liquid are merged, decompression, is concentrated into the thick paste that relative density is 1.32-1.42, then adds refined honey, and it is preferred that every 100kg thick paste adds refined honey 125-150kg(, and every 100kg thick paste adds refined honey 135-145kg; Be more preferably, every 100kg thick paste adds refined honey 140kg, then step (1), step (2) and step (3) gained fine powder is added and mix well, micro-refining, foam removal, seals and get final product in dress aseptic bottle.

8. the preparation method of esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament according to claim 7, is characterized in that, takes out and be placed on vinegar 2.5-4 two (preferably take out and be placed on vinegar per jin 3 liang in iron pan) per jin in iron pan in step (1).

9. the preparation method of esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament according to claim 7, is characterized in that, every 10 jin of Sal Ammoniacus vinegar 4.5-5.5 jin (preferably every 10 jin of Sal Ammoniacus vinegar 5 jin) in step (2).

10. the preparation method of esophageal carcinoma blood circulation promoting and blood stasis dispelling medicament according to claim 7, is characterized in that, is concentrated into the thick paste (being preferably concentrated into the thick paste that relative density is 1.37) that relative density is 1.35-1.39 in step (6).