CN110652552A

CN110652552A - Wound healing formula and preparation method

Info

Publication number: CN110652552A
Application number: CN201911060119.7A
Authority: CN
Inventors: 高国珍; 高倩
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-11-01
Filing date: 2019-11-01
Publication date: 2020-01-07

Abstract

The invention discloses a wound healing formula which comprises the following components in parts by weight: 80-100 parts of dragon's blood, 85-95 parts of catechu, 80-100 parts of pseudo-ginseng, 85-95 parts of prepared frankincense, 8-12 parts of borneol, 85-95 parts of prepared myrrh, 8-12 parts of musk, 160 parts of crinis carbonisatus 140, 25-35 parts of camphor, 25-35 parts of calomel, 85-95 parts of calcined gypsum, 80-100 parts of calcined keel, 25-35 parts of lithospermum, 20-40 parts of angelica dahurica, 25-35 parts of angelica, 20-40 parts of liquorice, 160 parts of red halloysite 140 and 85-95 parts of white pepper. The invention can be widely used for various wound infections, has short treatment time, high healing rate and obvious curative effect, obviously relieves pain after being used for 1 to 2 hours, can generate fresh granulation tissues after 2 to 3 days, obviously reduces lacunar secretions, cleans the wound surface and does not need oral antibiotics.

Description

Wound healing formula and preparation method

Technical Field

The invention relates to the technical field of wound healing medicines, in particular to a wound healing formula and a preparation method thereof.

Background

With the increasing population and the development of working environment and living environment, the phenomena of physical injury, operation incision, sports fracture and difficult healing after trauma caused by various internal diseases are common in clinic, and aiming at the conditions that the wounds of various clinical traumas, operation incision, open fracture debridement and suture, burn and scald, diabetic foot, bedsore and the like are difficult to heal due to infection caused by personal physical problems, the wounds need to be restored to the wounds before being damaged in a short time by virtue of medicines, at present, no medicine for treating various wound infections, short treatment time, high healing rate and obvious curative effect can relieve the pain of patients.

Disclosure of Invention

In order to overcome the defects in the prior art, the embodiment of the invention provides a wound healing formula and a preparation method, which are developed based on years of experience, can solve the problems of wound repair in a short time and rapid tissue regeneration promotion of an organism, have the technical effects of promoting tissue regeneration and healing wounds in 2-3 days and avoiding the use of antibiotics, and are low in cost; the wound is of various types and can be widely applied to clinic.

In order to achieve the purpose, the invention provides a wound healing formula according to the following technical scheme, which comprises the following components in parts by weight: 80-100 parts of dragon's blood, 85-95 parts of catechu, 85-95 parts of prepared myrrh, 80-100 parts of panax notoginseng, 85-95 parts of prepared frankincense, 8-12 parts of borneol, 8-12 parts of musk, 140-160 parts of crinis carbonisatus, 25-35 parts of camphor, 25-35 parts of calomel, 85-95 parts of calcined gypsum, 80-100 parts of calcined keel, 25-35 parts of lithospermum, 20-40 parts of angelica dahurica, 25-35 parts of angelica, 20-40 parts of liquorice, 140-160 parts of red halloysite and 85-95 parts of white pepper.

Further comprises the following components in parts by weight: 90 parts of dragon's blood, 90 parts of catechu, 90 parts of pseudo-ginseng, 90 parts of prepared frankincense, 10 parts of borneol, 10 parts of musk, 150 parts of crinis carbonisatus, 30 parts of camphor, 30 parts of calomel, 90 parts of calcined gypsum, 90 parts of calcined keel, 30 parts of lithospermum, 90 parts of prepared myrrh, 30 parts of angelica dahurica, 30 parts of angelica, 30 parts of liquorice, 150 parts of red halloysite and 90 parts of white pepper.

Further comprises the following components in parts by weight: 80 parts of dragon's blood, 85 parts of prepared myrrh, 85 parts of catechu, 80 parts of panax notoginseng, 85 parts of prepared frankincense, 8 parts of borneol, 8 parts of musk, 140 parts of crinis carbonisatus, 25 parts of camphor, 25 parts of calomel, 85 parts of calcined gypsum, 80 parts of calcined keel, 25 parts of lithospermum, 20 parts of angelica dahurica, 25 parts of angelica, 20 parts of liquorice, 140 parts of red halloysite and 85 parts of white pepper.

Further comprises the following components in parts by weight: 100 parts of dragon's blood, 95 parts of prepared myrrh, 95 parts of catechu, 100 parts of panax notoginseng, 95 parts of prepared frankincense, 12 parts of borneol, 12 parts of musk, 160 parts of crinis carbonisatus, 35 parts of camphor, 35 parts of calomel, 95 parts of calcined gypsum, 100 parts of calcined keel, 35 parts of lithospermum, 40 parts of angelica dahurica, 35 parts of angelica, 40 parts of liquorice, 160 parts of red halloysite and 95 parts of white pepper.

Further, 15-20 parts of euglena; the Euglena comprises one or more of Chlamydomonas, Lupinus pinnatifida, and Microcoleus powder.

Further comprises 8 parts of wax apple extract and 12 parts of fresh orange peel extract.

The invention also provides a preparation method of the wound healing formula, which comprises the following steps:

selecting the medicinal materials with better quality for standby;

drying the above medicinal materials for use;

placing the dried medicinal materials into a stirring barrel, and mixing at a speed of 30-40 rpm for more than fifteen minutes;

adding the uniformly mixed medicinal materials into a grinding machine and processing into medicinal powder;

sieving the ground medicinal powder with a 180-mesh sieve, and uniformly sieving;

irradiating the sieved powder with ultraviolet rays for at least one hour, and bottling.

Further, a mixture can be added before bottling the medicinal powder, wherein the mixture is one or more of deionized water, beeswax, sesame oil and vaseline, and the mixture is prepared into paste.

Further, the preparation of the wax apple extract comprises the following steps: freezing wax apples at the temperature of 30-minus 10 ℃ for 1.6-2.0 h, adding water for pulping, and blanching by a hot water bath at the temperature of 100 ℃ for 12-20 min to obtain wax apple pulp; using 18-25% ethanol as solvent, extracting at 80-90 deg.C for 3 times (each time for 2-4 hr) with solvent amount 10-14 times of the weight of Syzygium samarangense; filtering, mixing extractive solutions, recovering ethanol, concentrating to relative density of 0.98-1.2, and filtering to obtain medicinal liquid A;

passing the obtained liquid medicine A through nonpolar macroporous adsorption resin, eluting with water, passing the water eluate through the polar macroporous adsorption resin directly, eluting the nonpolar macroporous adsorption resin with 50% -60% ethanol solution, collecting ethanol eluates with different concentrations, concentrating, and drying to obtain wax apple extract A; eluting the polar macroporous adsorption resin by using 70-85% ethanol solution, collecting ethanol eluates with different concentrations, concentrating and drying to obtain a wax apple extract B;

and (3) uniformly mixing the wax apple extract A and the wax apple extract B to obtain the wax apple extract.

1. Wax apple

Wax apple, also known as Eugenia jambolana, is called "Dianxian" in Hainan and "Gongdong" in Guangdong. It is a tropical fruit with high taste and nutritive value. The functions and effects of wax apple are as follows:

1) and (5) crease resistance and water supplement. The wax apple is a fruit with extremely high water content, is rich in vitamin C, and has good water replenishing effect on skin after being eaten. Meanwhile, the wax apple also contains the pericarp anthocyanin, which can eliminate harmful free radicals in the body and prevent the generation of wrinkles in advance, so the wax apple has the effects of preventing wrinkles and supplementing water.

2) To calm heart and induce tranquilization. The magnesium and calcium elements contained in wax apple can relieve tension of muscles and nerves, avoid some anxiety, and simultaneously carbohydrate can supplement glucose consumed by brain, relieve fatigue, insomnia and amnesia, and has effects of calming heart and tranquilizing mind.

3) The swelling-diminishing and diuresis-inducing wax apple contains a certain amount of sylvite, and after the ingredients enter a human body, redundant water can be discharged, so that the swelling-diminishing effect can be achieved, and meanwhile, the water content of the wax apple reaches about 90%, so that the wax apple has a good diuresis-inducing effect.

4) Clearing away heat and toxic material. The wax apple contains a natural special fragrance and is a natural heat-eliminating agent. Meanwhile, the vitamin C contained in the health-care food can remove harmful substances in the liver and improve the health, so that the health-care food has the effects of clearing away heat and toxic materials.

5) Cool blood to relieve cough. The wax apple belongs to a cold food material, has good blood cooling effect after being eaten, also contains glucose and microelements of various vitamins, and has certain treatment effect on chronic cough and asthma.

6) Promoting appetite and digestion. The wax apple contains a certain organic acid component, can stimulate the secretion of digestive glands of a human body, increases the appetite of the human body, well promotes digestion, has the characteristics of fresh and sweet taste, light fragrance and wateriness, and is a holy product for quenching thirst and helping digestion.

7) Building up body. The wax apple contains certain protein and fat, and trace elements such as calcium, potassium, magnesium and the like, which are essential nutrient elements for human bodies, and can regulate various functions of the human bodies, increase the immunity and the antibacterial ability of the human bodies and have the effect of building up the bodies.

2. Orange peel

Orange peel, the pericarp of orange, is bitter, pungent and warm in nature. The pericarp contains hesperidin, volatile oil, pectin, carotene, etc. The orange peel is pericarp of Citrus aurantium of Rutaceae, and has effects of promoting skin metabolism and improving resistance of skin capillary. Many friends like to eat oranges, the juice has sweet and fragrant taste, and the fact that the oranges are not only expressed on the flesh of the fruits but also have great efficacy and effect on the orange peel is unknown to the friends. The orange peel can be soaked in water for drinking after being dried and comfortable, is not only very light and thirst quenching, but also has good effects of promoting digestion and invigorating stomach, and can also play a role in regulating some people with poor spleen and stomach functions. The orange peel has the following functions and efficacies:

1) descending adverse flow of qi and resolving phlegm

The orange peel is a good traditional Chinese medicine material, is stored after being dried in the sun, and if the phenomenon of excessive phlegm and cough occurs, a proper amount of orange peel can be taken out and soaked in water for drinking, so that the orange peel can effectively resolve phlegm and descend the adverse qi.

2) Promote digestion and harmonize stomach

The orange peel has the effect of promoting digestion besides the effect of reducing phlegm. The pickled dried orange peels sold in the market are prepared into snacks for invigorating stomach and promoting digestion by utilizing the digestion promoting effect of orange peels.

3) Killing fish and crab toxin

If seafood such as sea fish and crab is poisoned, a cup of orange peel water can be soaked first, and fish and crab poison can be killed.

4) Treating chest and diaphragm qi stagnation

The orange peel has good effects of regulating qi and reducing phlegm, so that the orange peel can have good effect when being used for making tea to drink when chest distress and qi stagnation occur.

5) Refreshing and refreshing

The orange peel contains a large amount of essential oil, emits light orange fragrance, and has the effects of refreshing air and refreshing brain. Especially, the effect is more obvious in a closed space, such as when a driver sits for a long distance, and a plurality of orange peels can be placed beside the driver if the driver does a carsickness.

6) Hair care and beauty treatment

The orange peel is put into hot water, and can be used for washing hair to make hair smooth and soft. In addition, the orange peel can be used for washing face and has the effect of whitening skin.

4. Catechu

Catechu (scientific name: Acacia catechu) is a plant of the genus Acacia of the Leguminosae family. The efficacy and effect of catechu are as follows:

1) liver protection and gallbladder function: the product contains d-catechin and epicatechin, and has effect in protecting liver. The D-catechin 150mg/kg has protective effect on liver injury caused by carbon tetrachloride, and can significantly reduce alanine Aminotransferase (ALT), reverse inverted albumin/globulin (A/G), increase glutathione-S-transferase (GST) activity, and promote liver detoxification function. The D-catechin can antagonize liver injury caused by muscarine, phalloidine and acetaminophen, has obvious protective effect on rat liver steatosis caused by homocystine S and malonic acid and rat liver steatosis D-catechin caused by low-protein and high-fat diet of 50mg/kg subcutaneous injection, and can also obviously prevent liver steatosis D-catechin caused by uracil-6-carboxylic acid or ethanol. The liver protection effect of D-catechin is related to the effects of promoting ATP synthesis in liver, stabilizing lysosome membrane, scavenging free radicals, resisting oxidation, resisting endotoxin and resisting fat infiltration. It is also indicated that the liver-protecting action of this tea essence is related to its strong free radical scavenging action. The duodenal administration of the catechin 50mg/kg or 75mg/kg can also significantly increase the bile flow of anesthetized dogs or rats, and the effect lasts for 3 hours or 60-80min respectively.

2) Impact on immune function: in the absence of antigen, d-catechin did not affect leukocyte migration, but in vitro studies inhibited migration of normal human leukocytes which were sensitive to Purified Protein Derivative (PPD) antigen, whereas in patients who had been infected with hepatitis B and were sensitive to hepatitis B surface antigen, it was more inhibitory to leukocyte migration, indicating that it was able to amplify cell-mediated immune responses and promote clearance of hepatitis B antigen. The D-catechin can also reduce the number of wide lymphocytes of patients with chronic hepatitis and restore the normal state, and promote the transformation of the lymphocytes of the patients with chronic liver disease who have positive reaction to old tuberculin under the induction of PPD. The d-catechin can activate normal human peripheral blood Ts cells and inhibit the maternal cell transformation induced by concanavalin A (ConA), but the d-catechin can obviously inhibit the Ts function and inhibit the generation of Ig in patients with slow-living liver.

3) The function of resisting pathogenic microorganisms: in vitro bacteriostatic tests show that the Minimum Inhibitory Concentration (MIC) of catechu is 2.8lmg/ml for Staphylococcus aureus, 5.63mg/ml for Staphylococcus albus, 5.63mg/ml for beta hemolytic streptococcus, and 5.63mg/ml for Candida albicans, and catechu has also been reported to be directed against Pseudomonas aeruginosa, Corynebacterium diphtheriae, and Bacillus proteus. Dysentery bacillus, typhoid bacillus, etc. The susceptibility of 5% catechu suspension to 68 strains of dysentery bacillus in the susceptibility test to shigella flexneri and shigella baumannii is 100%. In addition, the compound also has obvious inhibiting effect on viruses and certain fungi.

5) The hypoglycemic effect: indian folk uses Catechu to treat diabetes, and the product contains epicatechin which can promote ATP, temperature and concentration dependent insulin secretion of rat, and the total injection of epicatechin for 4 days can increase insulin content in rat insulin by 30% and promote DNA synthesis in islet, wherein the insulin secretion is 30mg/kg daily for 2 times. The D-catechin also has blood sugar lowering effect on rabbit.

6) In vivo process: [14C] d-catechin is orally taken, the absorption rate is more than 70%, and the peak concentration is reached within 1-3 h. When the medicine is orally taken by 0.5g, 1.0g and 2.0g, the serum concentration is higher and lower according to the dose, but the relative bioavailability is approximately similar, and the medicine has no gastrointestinal saturation absorption and dose-dependent first-pass effect. The apparent elimination half-life of the original compound is 1-1.5h, the former compound is about 0.5% of the urine excretion in the original form, and the excretion can be completed in about 8 h.

7) Toxic catechu tannic acid: the mice can be killed by being injected with 200-300mg/kg for intravenous injection, and the mice fed with the feed containing 3-5% of catechu tannic acid for 1 month can not cause the death of the animals. The LD50 of the catechins drenched on the mice is more than l.37g/kg.

5. Notoginseng radix

Pseudo-ginseng is called pseudo-ginseng because its branches are divided into three branches and seven tablets, also called pseudo-ginseng, jinbuhui and so on, and also called showa, xue shen, ginseng pseudo-ginseng, shanqi, pseudo-ginseng and so on in ancient times. The pseudo-ginseng has the following effects and effects:

1) effects of panax notoginseng on the blood and hematopoietic system:

(1) the Panax notoginseng has good hemostatic effect and can obviously shorten bleeding and blood coagulation time.

Studies show that the hemostatic component of Panax notoginseng is mainly Dencichine (Dentichine). The dencichine can promote platelet aggregation and deformation, and release ADP, platelet factor III, calcium ion, etc., to achieve hemostasis effect.

The reported cure rate of the panax notoginseng injection and panax notoginseng for treating gastric ulcer, duodenal bulbar ulcer hemorrhage, chronic gastritis and other digestive tract hemorrhage is more than 92.0%.

Pseudo-ginseng is used for treating patients with bronchiectasis, pulmonary tuberculosis and pulmonary abscess with hemoptysis, more than 80 percent of patients with complete hemostasis are treated by the pseudo-ginseng for 5 days, and the pseudo-ginseng is widely applied clinically for treating various traumatic hemorrhage and various internal blood diseases.

(2) The panax notoginseng can promote the division and growth of various blood cells and increase the number of the blood cells, and has the obvious blood enriching effect.

Experiments show that the panax notoginseng can obviously improve the number of red blood cells of pathological models (rats and rabbits) of the blood loss anemia, and has better treatment effect on the blood loss anemia.

The panax notoginseng saponins can obviously improve the phagocytosis rate of macrophages and the percentage of lymphocytes in blood besides improving the total number of white blood cells in peripheral blood of white mice.

(3) The panax notoginseng has obvious curative effects of promoting blood circulation to remove blood stasis and removing blood stasis to promote tissue regeneration.

Experiments show that the panax notoginseng saponins can obviously inhibit the formation of aortic intimal plaque of experimental atherosclerotic rabbits.

2) The function of panax notoginseng on the cardiovascular system:

experiments show that the panax notoginseng can reduce arterial pressure, heart rate and heart workload while obviously dilating blood vessels, reducing coronary resistance, increasing coronary flow, strengthening and improving coronary microcirculation and increasing nutritive myocardial blood flow, thereby obviously reducing myocardial oxygen consumption and being used for treating myocardial ischemia, angina and shock.

Experiments prove that the panax notoginseng saponins have a certain degree of antagonistic effect on various experimental arrhythmia models.

The total effective rate of treating coronary heart disease with radix notoginseng is reported to reach 97%, wherein the significant effective rate is 42.5%.

3) The panax notoginseng has the anti-inflammatory effect:

pharmacological experiments show that the panax notoginseng has obvious inhibition effect on vascular permeability increase caused by various reasons and has stronger anti-inflammatory effect. For example: the panax notoginseng has very obvious inhibition effect on connective tissue proliferative inflammation caused by subcutaneous cotton ball implantation on the back of a rat and granuloma caused by the cotton ball; the panax notoginseng saponins have obvious inhibition effect on mouse joint swelling caused by carrageenan and hyaluronidase and mouse auricle swelling caused by croton oil and xylene. Clinical application shows that: pseudo-ginseng has excellent effects of relieving swelling and pain when used for treating open fracture; the effect is obviously improved after the musk bone setting water is improved to pseudo-ginseng bone setting water.

4) Function of panax notoginseng on the immune system:

pharmacological experiments show that the panax notoginseng saponins can obviously improve the phagocytosis rate and the phagocytosis index of macrophages of mice, improve the total number of white blood cells in peripheral blood and reduce the movement index of the white blood cells; the panax notoginseng decoction or the panax notoginseng polysaccharide has obvious promotion effect on the generation of antigen binding cells in a mouse body; notoginsenoside has mitosis promoting effect on human lymphocyte in vitro.

In conclusion, the panax notoginseng has a certain immunoregulation function.

5) The anti-tumor effect of panax notoginseng is as follows:

in recent years, researchers at home and abroad have made a favorable progress on the research of the anti-tumor (cancer) action of panax notoginseng.

Research shows that panax notoginseng contains notoginsenoside, beta-elemene, trace element selenium and other anticancer active substances; rb1 with 120ug/ml concentration of notoginsenoside can inhibit 92% of cultured tumor cells, the inhibition rate of notoginsenoside Rd is 79%, and notoginsenoside Rh1 has obvious inhibition effect on cultured liver cancer cells; notoginsenoside Rh2 has strong antitumor activity, and can induce cancer cell to convert into non-cancer cell.

In addition, notoginsenoside and notoginsenoside polysaccharide can enhance the immune function of the organism, and have certain auxiliary effect on treating cancers.

6) The panax notoginseng has the effects of resisting oxidation and delaying aging:

abnormal accumulation of Lipid Peroxides (LPO) in the body is one of the major causes of aging in humans.

Experiments prove that the panax notoginseng can obviously improve the activity of SOD in brain tissues and blood of rats, obviously reduce the content of Lpo in the brain tissues and the blood and has the anti-aging effect.

7) Influence of panax notoginseng on substance metabolism:

research shows that the influence of panax notoginseng on human body substance metabolism is multifold:

the influence of notoginsenoside on blood sugar depends on animal state and organism blood sugar level, and can increase or decrease blood sugar, and has bidirectional balance and blood sugar regulating effects.

Panax notoginseng can affect blood lipid metabolism and reduce blood lipid level, especially the content of triglyceride is obviously reduced.

Panax notoginseng can promote protein synthesis in liver, kidney, testis and serum of mice.

Panax notoginseng has a promoting effect on deoxyribonucleic acid (DNA) synthesis of various organs and tissues of various experimental animals.

6. Processed frankincense

Frankincense, name of traditional Chinese medicine. Is resin exuded from bark of Boswellia carterii Birdw of Boswellia of Burseraceae and Boswellia bhauradaijiana Birdw of the same genus. The milk is classified into the species of frankincense somarie and the species of frankincense esophora, each of which is also in turn the same as the bead of frankincense and the original frankincense. The efficacy and effect of the prepared frankincense are as follows:

1) antipyretic analgesic

The frankincense is a traditional Chinese medicine capable of relieving fever and pain, the traditional Chinese medicine contains a large amount of natural volatile oil, the frankincense can directly act on nerves of human, the central nervous function can be improved, the pain and the fever can be quickly relieved and relieved, the frankincense can be used for treating fever, headache and other pain symptoms of people at ordinary times, and the treatment effect is particularly excellent.

2) Anti-inflammatory and antiseptic

The antiphlogistic and antiseptic effects are also one of the important effects of the frankincense, and after people take the frankincense at ordinary times, the antiphlogistic and antiseptic frankincense not only can improve the activity of endocytic cells of a human body, but also can promote the increase of white blood cells in the human body, and can accelerate the metabolism of the human body and eliminate various inflammations in the human body. In addition, the frankincense can also inhibit the generation of red blood cells of the sheep bone, increase the amount of antibodies in a human body, and can prevent corrosion, sterilize and promote the healing of wounds.

7. Borneol (borneol)

Borneol, other names: borneolum, Borneolum Syntheticum, borneolum, Borneolum Syntheticum, and Borneolum Syntheticum. The main components are as follows: the product is crystal obtained from resin and volatile oil of Borneolum, and is almost pure dextroborneol. The resin and volatile oil of Borneolum contain various terpenoids. In addition to borneol, it also contains parthenone such as humulene, beta-elemene, caryophyllene, etc., and triterpenoid such as oleanolic acid, hordenic acid, asiatic acid, camphol ketone, coca glycol, etc. The borneol has the following effects and effects:

1) the in vitro experiment of the bacteriostatic and anti-inflammatory effects shows that: borneolum (0.5%) with high concentration has antibacterial effect, synthetic Borneolum and natural Borneolum have the same antibacterial effect, and Borneolum and isoborneol have antibacterial effect; can obviously inhibit the egg white plantar swelling of the rat; isoborneol also has an inhibiting effect on croton oil auricle swelling, and the isoborneol is suggested to have an inhibiting effect on inflammatory processes such as fluid exudation and tissue edema.

2) The reports show that borneol can be used as an antifertility drug, and the application of the borneol as an antifertility drug dosage form of borneol can improve the bioavailability and enhance the antifertility action of the borneol.

8. Musk musk

Moschus is called "cun xiang", yuan cun, dangmen, weizi and xiang umbilici. The male deer in two years old starts to secrete musk, the optimal secretion period is about 10 years old, and each deer can secrete about 50g of musk. In addition, other scented animals such as muskiness may also have similar musk secretions. Drying, making into granule or block, with special fragrance and bitter taste, and making into spice or medicine. Is a central nerve stimulant, can relieve pain and reduce swelling when being externally used, and is also very precious. The musk has the following effects and effects:

1) action on the central nervous system

(1) The actions of musk or musk ketone on the central nervous system are not completely consistent and are not clear. The musk aqua and the musk suspension are injected into 50mg/kg vein or 2.5mg/kg lateral ventricle injection, so that the hypodermal electroencephalogram (EEG) of quiet conscious rabbits can be desynchronized in a short time, and part of animals are in a conscious alert state with behavior agitation, which indicates that the animals can excite cerebral cortex and enhance cortical electrical activity; the musk aqua has obvious awakening effect on pentobarbital sodium anesthesia rabbits, and lateral ventricle injection is more effective than intravenous injection, which indicates that musk can directly act on a central nervous system through a blood brain barrier.

(2) The musk suspension of 200mg/kg or the musk ketone of 5mg/kg is intragastrically infused for 2 days (4 times), the sleep time of the sodium pentobarbital can be remarkably shortened, but the sleep time caused by water, chloral and the sodium phenobarbital is not remarkably influenced; according to experimental results, the concentration of the pentobarbital sodium in brain tissues, liver homogenate and blood of the musk rat after the injection of the pentobarbital sodium is obviously lower than that of a control group; but has no obvious influence on the blood concentration of the pentobarbital sodium of rats which are pre-given with thioacetamide, and proves that the influence of musk and musk ketone on the pentobarbital sodium is caused by stimulating liver microsome drug invertase. Intragastric administration of Moschus 0.018-0.03 mg/mouse can resist nicotine induced convulsion of mouse, reduce acute toxicity, but increase acute toxicity of shikimic acid, strychnine, etc.; the natural muscone 0.01-0.05 mg/kg is administered by intragastric administration to prolong the positive condition reflex latency or eliminate reaction of most rats. The fragrant starch suspension is described to have an effect against acute toxicity of nicotine and increasing toxicity of strychnine in mice.

(3) The arone also has similar nicotine toxicity resistance to natural musk, so that the death number of mice is reduced by more than 2 times; increasing the toxicity of strychnine and increasing the death number of animals by 2-7 times. Injecting Moschus 25-100mg/kg into abdominal cavity of mouse; synthetic muscone or natural muscone 0.02-0.5mg/kg or natural Moschus 2mg/kg can shorten sleep time caused by sodium cyclohexarbital 100mg/kg or sodium pentobarbital. The mechanism of action of musk and musk ketone anti-hypnotics is not completely understood. 200mg/kg of musk suspension or 5mg/kg of musk ketone after being repeatedly infused into the stomach of a rat can obviously shorten the sleep time of the sodium pentobarbital, which is not directly excitatory to the center, but is the result of accelerating the metabolic inactivation of the sodium pentobarbital in the liver due to the fact that the musk suspension activates the action of liver microsome drug invertase. 1g/kg of natural musk or 500mg/kg of synthetic musk ketone and 100-100 mg of natural musk ketone can prolong the sleep time of mice caused by sodium pentobarbital. Therefore, it is believed that small doses of musk excite the central nervous system and large doses inhibit it. The musk has no obvious influence on the spontaneous activity of the mouse, so that the musk has no obvious excitation or inhibition effect on the center.

(4) Can obviously prolong the anoxic survival time of the mouse under the normal pressure environment; the musk is injected into the abdominal cavity at 200mg/kg, the hypoxia survival time of the mouse under the normal pressure environment can be obviously prolonged, the spontaneous activity of the mouse is not reduced, and the electrocardiogram and electroencephalogram synchronous recording of the rat proves that the effect is caused by the improvement of the tolerance of the central nervous system to the hypoxia state. The synchronous recording of rat EEG and electrocardiogram proves that musk can obviously prolong the existence time of EEG after acute respiratory arrest, but has no obvious influence on the existence time of electrocardiogram, the appearance time of hypoxia electrocardiogram and the like, which indicates that musk can possibly be the basis of the theory of aromatic resuscitation of musk for enhancing the hypoxia tolerance of the central nervous system.

(5) The intraperitoneal injection of 60-200mg/kg has obvious resistance to hypoxia at normal pressure, and can obviously prolong the survival time of mice. In addition, the external culture method of the rat cervical ganglion is applied, and the musk is found to have the function of promoting the division and the growth of the Schwann cells, which indicates that the musk has the function of a glial maturation factor.

2) Anti-inflammatory action

(1) Anti-inflammatory action: 500mg/kg of natural musk suspension and 65mg/kg or 130mg/kg of ether extract are injected into the abdominal cavity, and the natural musk suspension has obvious inhibition effect on mouse auricle swelling caused by croton oil. The musk aqueous extract has obvious inhibiting effect on agar arthritis, yeast arthritis, adjuvant type polyarthritis and cotton ball granulation tissue hyperplasia of rats by different metering and various administration modes; the injection has obvious inhibition effect on the permeability increase of scalding blood vessels of rats and the abdominal cavity leukocyte migration caused by carboxymethyl cellulose; the 50% inhibition dose of the musk polypeptide powder for intravenous injection on the ear inflammation of croton oil mice is 0.63mg/kg, which is 36 times of the action intensity of hydrocortisone. The musk water-soluble substance is injected into the vein by 80mg/kg, so that the vitamin C content in the epinephrine of a rat can be reduced, and the content of the peripheral blood corticosterone can be increased; the anti-inflammatory effect of the musk disappears after the adrenal gland of the mouse is cut off, but the anti-inflammatory effect of the musk still exists after the pituitary gland is cut off, which shows that the effect of the musk directly depends on the adrenal gland without the participation of the pituitary gland, and the musk still has obvious anti-inflammatory effect under the condition that the brain of the mouse is deeply inhibited by pentobarbital sodium, which shows that the effect of the musk is not in a central nervous system. The musk alcohol soluble component methanol in the extract of 400-. The musk has good anti-inflammatory effect on foot edema of rats caused by injecting tubercle bacillus, and on granuloma cyst and formaldehyde-filter paper ball granuloma cyst of rats caused by injecting croton oil, wherein the half inhibition dose (ID 50) of the musk is 388 mg/kg. Can also reduce the permeability of the skin capillary vessels of the mice, and the half inhibitory dose (ID 50) is 4.2 mg/kg.

(2) The anti-inflammatory results of a series of water-soluble isolates of musk at different doses showed that the anti-inflammatory intensity of musk-51 and-65 was 6 times that of hydrocortisone. 65-130mg/kg of musk diethyl ether extract and 500mg/kg of musk suspension are respectively injected into the abdominal cavity to inhibit ear inflammation swelling caused by croton oil of mice at the rates of 29.7-33.7% and 27-29.4%, and 12.5mg/kg of hydrocortisone is at the rate of 39-60%. The musk aqueous extract has very obvious inhibiting effect on mouse croton oil ear inflammation, rat agar joint swelling, yeast joint swelling and adjuvant type polyarthritis. The permeability of the scald blood vessel of the rat is increased. The carboxymethyl cellulose caused peritoneal leukocyte migration also has very obvious inhibition effect. The 50% inhibition dose of intravenous musk No. 1 (polypeptide with molecular weight of about 10,000) to ear inflammation of croton oil mice is 0.63mg/kg, which is 36 times of the action intensity of hydrocortisone, and is more than 500 times of the action intensity of hydrocortisone compared with the molar dose. Half of the lethal dose and 95% confidence limit of the intravenous injection musk aqueous extract on mice are 848 +/-104 mg/kg. The musk water-soluble substance can reduce the content of vitamin C in rat adrenal gland, increase the content of peripheral blood corticosterone, eliminate the anti-inflammatory effect after the adrenal gland is cut off, but still have the anti-inflammatory effect after the pituitary gland is cut off, which shows that the anti-inflammatory effect of the adrenal gland and the musk water-soluble substance is closely related. The Moschus water soluble extract can inhibit platelet aggregation. These effects of increasing plasma cAMP levels are similar to non-steroidal anti-inflammatory drugs; however, aqueous musk solutions enhanced 615 mouse immune hemolytic effects, suggesting that they may exert anti-inflammatory effects through immunomodulation. Muscone contained in Moschus has antiinflammatory effect only when l00mg/kg is intraperitoneally injected, and half effective amount of polypeptide extracted from Moschus for inhibiting mouse ear inflammation caused by croton oil is 0.63mg/kg, which shows that muscone is not the main antiinflammatory effective component of Moschus.

3) Influence on immune function

The water soluble protein of Moschus has effects of enhancing humoral immunity and cellular immunity. The experiment shows that musk has no inhibiting effect on the intraabdominal injection of sheep red blood cell immune mouse antibody gavage M. It is likely to have enhancement effect. The musk has no immune induction effect, but in the presence of antigen sheep red blood cells, the musk can obviously enlarge the spleen of an experimental mouse.

7. Crinis Carbonisatus

Crinis Carbonisatus, also called crinis Carbonisatus, is prepared by calcining human hair. Collecting human hair, washing with alkali water to remove dirt, rinsing with clear water, and drying in the sun. Calcined into charcoal. The action and efficacy of crinis Carbonisatus:

1) the application of the water decoction or alcohol extract of the crinis Carbonisatus to the abdominal cavity of a rat or a mouse can obviously shorten the bleeding time. The crinis Carbonisatus crude crystal liquid is administered to abdominal cavity of rat to accelerate blood coagulation of rat; and can induce platelet aggregation in rats; shorten the blood coagulation time of dogs and rabbits. The report indicates that the crinis carbonisatus coarse crystals have a relatively obvious enhancement effect on ADP-induced rat platelet aggregation, and can also obviously reduce the cAMP content in rat plasma. The report also indicates that the crude liquid of the carbonized human hair has the enhancement effect on platelet aggregation of rats induced by ADP, has the increasing trend on the adhesion rate of the platelets, can obviously shorten the partial thromboplastin time of the kaolin, can obviously reduce the content of cyclic nucleotide in the platelets and has certain anti-inflammatory effect. It has been reported that the pharmacological activity and action properties of crinis Carbonisatus vary depending on the processing conditions. Crinis Carbonisatus (processed product at 350 deg.C) has strongest hemostatic effect when administered orally, while decoction (processed product below 300 deg.C) has central excitation effect when injected.

2) The anti-bacterial hair dye decoction has strong inhibiting effect on staphylococcus aureus, typhoid bacillus, paratyphoid bacillus A and shigella flexneri.

10. Camphor

The Camphora is granular crystal extracted from branches, stems, leaves and roots of Cinnamomum camphora of Lauraceae. The main component is pure d-Camphora, which is a camphene compound. Camphor, evergreen arbor, 20-30m high. The bark is dark brown or yellow brown, and has split longitudinal section, light brown small branch, smooth, and camphor smell on both branch and leaf. The leaves are intertriginous, leathery, oval or oval, 6-12cm long, 3-6cm wide, tapered at the tip, blunt or wedge-shaped at the base, full-edged or wavy, dark green and glossy at the upper part, grayish green or pink white at the lower part, hairless, pale red young leaves, pulse above the base 3, swollen glands in the axilla of the pulse, and 2-3cm long petiole. Axillary growth of the panicle, small flower, green white or light yellow with the length of about 2mm, 6 cleft flower perianth with the length of about 2mm, dense and thin and soft hair on the inner surface, fertile stamen 9, anther 4 chamber, ovate shape, smoothness, no hair, short style of flower and head shape of stigma. The stone fruit is spherical, about 1cm wide, purple-black when ripe, and the base is surrounded by the lodging and expanding flower envelope. The flowering period is 4-6 months. The fruit period is 8-11 months. The main effects and actions of camphor:

1) the topical application of Camphora to skin has mild irritation and antiseptic effects. The strong rubbing can produce reddish hair, while the light rubbing can be similar to peppermint, which can produce cool feeling due to the stimulation of the cold receptors. It also has mild local anesthetic action. For gastrointestinal mucosa, camphor has stimulating effect, and makes stomach feel warm and comfortable, and large amount of camphor can cause nausea and vomiting. The camphor liniment has the functions of easing pain and relieving itching clinically. It has the actions of expelling wind and eliminating phlegm.

2) The camphor has the effect on the central nervous system, and the camphor has the systemic effect of exciting the central nervous system, is particularly remarkable for the higher central nervous system, and can act on a large number of cerebral cortex motor areas and brainstems to cause epileptiform convulsion. The camphor in the usual dose has no obvious effect on the respiration, and in the extreme inhibition condition, some respiratory excitation can be seen, mainly due to the reflex excitation caused by the stimulating receptors when injected subcutaneously.

3) The camphor preparation is widely used as a heart-strengthening medicine once and for all, but results reported by various people are quite inconsistent and have not been determined to date. It has no digitalis or adrenaline-like action. Has no effect on normal myocardium, and high concentration inhibits it. In isolated hearts, excitation is seen only when failure occurs. It has exciting effect on blood vessel movement, and only when its function is extremely low, it can cause visceral blood vessel contraction and skin vasodilatation, and blood pressure increase. Therefore, it is considered to be effective for circulatory collapse or acute heart failure, but some people have suspicion or negative attitude for the curative effect. It has been reported that camphor has a remarkable cardiotonic, pressor and respiratory stimulant action, a water-soluble metabolite of camphor in animals, and is known under the trade name vitaamphor (vitaamphor). Use with cautions for pregnant women.

4) In vivo, Camphora can be absorbed easily through mucosa, subcutaneous tissue and muscle. The oral administration is also quick. Detoxify rather rapidly in the liver, oxidize to camphorol, and then combine with glucuronic acid to be excreted in the urine. The camphor concentration of 1:25000 can completely relieve the spasmodic effect of the carbamylcholine (1:600 ten thousand) on the intestines of the rabbits in vitro, the camphor concentration of 50mg/kg can intensify the tremor caused by the arecoline when the camphor concentration of 100mg/kg is given to mice, and the spasmodic effect of the nicotine (20mg/kg) can be prevented. Camphor has exciting effect on central nervous system, but has no selectivity to respiratory center, and toxic dose can cause convulsion, a small amount of oral administration can produce warm and comfortable feeling in stomach, a large amount of oral administration can cause irritation, and can cause nausea and emesis, and rubbing on skin can cause redness, and has slight local anesthesia effect, and can be applied on skin to give numbness.

11. Calomelas

The calomel mainly contains mercurous chloride. The natural product, named Kejia mercury mine, is usually prepared artificially and is tasteless and colorless (usually with light yellow) scaly crystal. Chemically named as calomel, the dried product of the calomel contains not less than 99.6 percent of HgCl. Although the toxicity of the product is low, the product is boiled with water and decomposed into mercury chloride and metallic mercury, and the latter two are highly toxic; during exposure, calomel gradually becomes darker and also changes in color, which is very toxic. The efficacies and effects of the calomel are as follows:

the calomel has the function of sterilization when being used externally, and can inhibit abnormal fermentation in the intestines and relieve constipation when being taken orally in proper amount. After the calomel is taken orally, the calomel is changed into easily soluble divalent mercury ions in the intestine when meeting alkali and bile. Divalent mercury ions can inhibit the metabolism and functional activity of intestinal wall cells, and prevent the absorption of electrolytes and water in the intestines to cause purgation; and can inhibit intestinal bacteria from converting biliverdin into bilirubin, and promote the conversion of biliverdin due to the rapid discharge of intestinal contents, so that the stool can be green after administration. After the divalent mercury ions are absorbed, the mercury ions can be combined with thiol-containing enzyme in renal tubular cells to inhibit the activity of the enzyme, influence the reabsorption function of the enzyme and promote the urination. Large amount of the drug can cause poisoning. The gum arabic is used for preparing a calomel suspension, and the stomach is irrigated, wherein the half lethal dose of the calomel suspension is 410 mg/kg, and the rat lethal dose is 1740 mg/kg. The heart, liver and kidney of the poisoned mouse have pathological changes of different degrees, the renal tubular epithelial cells are most obvious and have turbidicity, lipid change, necrosis and the like, and part of the ovary is broken by larger follicles and has leukocyte infiltration. The light powder water infusion (1: 3) has different degrees of inhibition effects on trichophyton violaceum, yellow ringworm of the Lanceflower, Paecilomyces orientalis, epidermophyton rubrum, Nocardia stellatoides and other dermatophytes in test tubes.

12. Calcined gypsum

The calcined gypsum is white powder or loose block, and has reddish luster and opacity. Light weight, soft, fragile, and crumbly into powder. No smell, light taste. The efficacy and the effect of calcined gypsum are as follows:

1) the calcined gypsum is considered to be a substance with sweet, pungent, astringent and cold properties in traditional Chinese medicine, and can be used for medicine, and is prepared by putting clean gypsum into a smokeless furnace fire or a crucible for calcining until the gypsum is loosened, taking out the gypsum, cooling the gypsum and then smashing the gypsum to form the calcined gypsum.

2) The calcined gypsum is white with powder, is a relatively loose block, looks like the surface of the calcined gypsum is reddish, is opaque, is relatively soft, is easy to break, has light taste and no odor. Calcined gypsum is used as a medicine, and is applied to an affected part after being ground into powder. And (4) finishing.

3) Gypsum Fibrosum Preparatum has good effects of eliminating dampness and promoting granulation, has good therapeutic effect on wound healing, has good hemostatic effect, can be used for treating ulcer, has good therapeutic effect on eczema pruritus and scald due to hot water and fire, and can also be used for treating traumatic hemorrhage. Turning Gypsum Fibrosum Preparatum into powder for use, and also has heat clearing effect.

13. Calcined keel

Os Draconis is fossil of skeleton of ancient mammals such as elephant, Rhinoceros, and radix et rhizoma Rhei. Calcining the brushed keels on smokeless fire or in a crucible to be red, taking out, cooling, and grinding to obtain the calcined keels. The efficacy and the effect of calcined keel are as follows:

1) induce tranquilization and relieve convulsion. Calcined keel is a good medicinal material for relieving convulsion and calming mind, and parents can use calcined keel to help children calm mind and calm mind if children are frightened by accident. Treating insomnia

2) It can be used for treating insomnia. The calcined keel is mainly calcium carbonate and calcium phosphate, and also contains iron, potassium, sodium, chlorine, sulfate radical and the like. The tongue is sticky and astringent, and has a strong tendency to flutter and relax. Has certain effect on insomnia. Treating ulcer

3) Can be used for treating ulcer. The calcined keel can treat the phenomenon that the ulcer is not closed for a long time, so that the wound is closed in the shortest time, and the effect is quick. Treating palpitation and amnesia

4) Treating palpitation and amnesia. The calcined keel can also treat severe palpitation and amnesia, can help your memory to be best preserved and restored, and solves various troubles caused by amnesia in life. If a forgetful person is present, it can also be selected for treatment trials.

14. Lithospermum erythrorhizon

Lithospermum erythrorhizon Sieb. et Zucc. is a perennial herb of the genus Lithospermum of the family Boraginaceae, up to 90 cm. Upright root, cylindrical, slightly curved, often divergent, dark red-purple peel. The stem stands upright, single or partially divergent, and the whole plant is harped. The leaves are intergrown without stalks; the long round shape of the leaf is needle-shaped, the length is about 6cm, the width is about 1.3 cm, the tip is sharp, the base is wedge-shaped, the whole edge is rough and rough on both sides. The head of the parasol inflorescence is in a general shape and grows; the flower is amphoteric; leaf-shaped bract with rough hair on both sides; the calyx is short and cylindrical, 5 deep cracks, and the lobe is narrow and sharp; the corolla is white, the corolla tube is short, the tip is 5-split, the throat is provided with 5 flaky appendages, and the base is provided with a hairy object. The functions and effects of lithospermum are as follows:

1) antibacterial and anti-inflammatory effects: the radix Arnebiae has effect in inhibiting Peking 68-1 virus in vitro, and also has effect in inhibiting Staphylococcus aureus and Bacillus prodigiosus. The tincture of radix Arnebiae produced in the joint process of radix Aconiti and radix Aconiti Kusnezoffii has effect in inhibiting suppurative bacteria and Escherichia coli. And can accelerate epithelial growth and treat burn. The ether or water extract of Japanese Lithospermum erythrorhizon root can inhibit capillary permeability by oral administration or topical application (intracutaneous pigment exudation method in rat); the oral extract 100 ml/kg has the same inhibitory effect on rat hindlimb edema caused by carrageenan as bupropion, and shikonin and acetylshikonin have the same anti-inflammatory effect. Topical application can promote wound healing. The Ziyun ointment prepared from the alkanna tinctoria root and the angelica has better effect than the single medicine. The lithospermum decoction has certain curative effect on the tuberculosis of mice. But not in guinea pigs. The plate method is used for testing the inhibition of various fungi. Radix Arnebiae extract can be used for treating facial tinea.

2) Influence on the circulation system: xinjiang soft gromwell (purchased from Taiyuan, with uncertain variety) decoction has obvious excitation effect on isolated or whole heart of healthy rabbit and toad, and the effect is related to calcium content in the decoction. The decoction can be injected intravenously or intramuscularly under general anesthesia to cause blood pressure of nearly half animals (rabbits, dogs and cats) to drop sharply and even die, but patients who are not anesthetized or orally taken do not have the serious reaction. Has no influence on the perfusion of toad visceral vessels, rabbit hind limbs and isolated rabbit ears.

15. Root of Dahurian Angelica

Radix Angelicae Dahuricae (academic name: Angelica Dahurica) is a plant belonging to the family Umbelliferae, Angelica. Are distributed in northeast and northeast China of China, grow in areas with an altitude of 200-1,500 m, and generally grow under forests, forest borders, stream sides, shrubs and valley grasslands. Alias: xingan angelica dahurica (Chinese higher plant image), hebei pubescent angelica root (Beijing plant), Dahuo, xiangdao, herba ramuli japonici (northeast), and radix euphorbiae ebractealatae (Heilongjiang). The effect and action of the angelica dahurica are as follows:

1) dispelling wind and relieving exterior syndrome: can be used for treating common cold, wind-cold, headache, nasal obstruction, etc., and has effects of dispelling pathogenic wind-cold and relieving pain. It is usually combined with Xanthium sibiricum and Magnolia liliflora, for example (Jiuwei Qianghuo Tang) and (hygienic Baozhen Baishen san).

2) Dispelling wind and relieving pain: can be used for treating headache, migraine, supraorbital pain, nasosinusitis headache, toothache, etc., and has effects in dispelling pathogenic wind and relieving pain, such as (CHUANXIONGCHATIAO powder, DULIANGWAN pill), (< FURENLIANGLIANG powder), (< DANXI EYEFRAME pain relieving formula).

3) Dissipation and pus discharge: for carbuncle, swelling, sore and ulcer, it can dissipate at its beginning and discharge pus after ulceration, for example (Xianfang Huoming Yin, Tuo Li Shu pus Tang).

4) Drying dampness and stopping leukorrhagia: for leukorrhagia due to cold-dampness, it can dry dampness and stop leukorrhagia, and is combined with Hai Piao Xiao; it is indicated for leukorrhagia due to damp-heat, yellow and thick leucorrhea, and can be combined with heat-clearing and dampness-drying herbs, such as Huang Bai and Ailanthus altissima bark.

5) Freeing nasal orifices: for long-term running of thick nasal discharge and no smell of odor in nasosinusitis, it is combined with Xinyi, cang Er Zi, Fang Feng and Chuan Xiong, such as Bai Zhi Wan.

16. Radix Angelicae sinensis

Angelica sinensis (with the scientific name: Angelica sinensis) is also called Angelica sinensis, Qibang, Xiangelicae sinensis, Minangelicae sinensis, Angelica sinensis Dahurica, and Aralia cordata, and is herbaceous for many years and 0.4-1 m higher. The flowering period is 6-7 months, and the fruit period is 7-9 months. The root of it can be used as a medicine, and is one of the most commonly used Chinese herbs. The functions and effects of angelica are:

1) antithrombotic effect

The angelica sinensis aqua has obvious inhibiting effect on the formation of artery and vein bypass thrombus of rats by intravenous injection or oral administration.

2) Improving blood circulation

When the butylphthalide in the angelica can increase the diameter and the blood flow velocity of the leptomeningeal arteriole after the Middle Cerebral Artery Occlusion (MCAO), thereby improving the leptomeningeal microcirculation. The apoptosis of neurons exists in the cerebral ischemia process, and the butylphthalide can weaken or stop the low-sugar hypoxia-induced apoptosis process of nerve cells and prevent the cerebral infarction area from expanding.

3) Action on the cardiovascular System

The radix Angelicae sinensis decoction or fluid extract has effect in inhibiting isolated Bufo siccus heart, and can stop heartbeat in diastole when dosage is large. The angelica has a protective effect on arrhythmia of myocardial ischemia reperfusion of rats, and 0.6g/kg of angelica injection is used for intraperitoneal injection of rats, so that the incidence rate of premature beat and the total incidence rate of arrhythmia are obviously reduced.

4) Anti-inflammatory and analgesic effects

The angelica has obvious inhibition effect on acute capillary permeability increase, tissue edema and chronic injury caused by various inflammatory agents, can inhibit granulation tissue hyperplasia at the later stage of inflammation, but does not influence the weight of adrenal gland and thymus, and suggests that the anti-inflammatory effect of the angelica does not depend on a pituitary-adrenal system. The water extract of angelica shows analgesic effect on writhing reaction caused by intraperitoneal injection of acetic acid, and the analgesic effect strength is 1.7 times of that of sodium acetylsalicylate.

5) Anti-inflammatory action

(1) Effect of swelling of mouse auricle due to p-xylene.

(2) The influence on the increase of the permeability of capillary vessels in the abdominal cavity of the mouse caused by acetic acid.

Mice were taken and randomly grouped, 9 per group. After l hours from the last administration, the mice were sacrificed 30 minutes after the literature method (WhittleBA, 1964) with tail iv0, 5% Evans blue 5ml/kg, immediately ip0, 7% acetic acid 10ml/kg, the abdominal cavity was excised, repeatedly rinsed with normal saline, the rinse was collected and adjusted to a final volume of 10ml, centrifuged, the supernatant was taken, and absorbance was measured at 610nm using 721 spectrophotometer. As a result, 10g/kg of Angelica sinensis can significantly inhibit the increase of the permeability of the capillary blood in the abdominal cavity.

(3) The effect on swelling of rat footpads caused by inflammatory agents.

Rats were taken and randomly grouped, 7 feet per group. 1 hour after the last administration, the rats had hind footpads of sc1% carrageenan, 2.5% formaldehyde, and 0.1ml each of fresh egg white, measured 1 time every 1 hour after the inflammation (1 time for the formaldehyde group 2 hours after each day administration, 5 times total) using a micrometer, so that the difference in footpad thickness before and after the inflammation indicates the degree of swelling, according to the literature (xu Tertiary cloud et al, pharmacological experimental methodology). As a result, the angelica has obvious inhibition effect on the swelling of the footpad of 3 kinds of inflammation agents.

(4) The effect on the swelling of carrageenan footpads of adrenal-deprived rats.

Rat adrenal resection was performed by the conventional method, ether anesthesia was performed, a transverse incision was made under the twelfth rib of the back, the lateral adrenal glands were removed, im penicillin was 250mg/kg anti-infection after surgery, and 1% NaCl was used instead of tap water for feeding. On day 2, rats were randomized and dosed simultaneously. 1 hour after the last administration, the swelling degree of the foot pad was measured by the same method as above, except that the inflammation was caused by sc1% carrageenan 0 and 1ml in the right and rear foot pads. The result is; the angelica still has obvious anti-inflammatory effect on rats without adrenal gland.

(5) The effect on the increase of the permeability of the skin capillaries of the rat caused by the histamine.

Rats were taken and randomly grouped, 7 per group. After 1 hour from the last administration, rats were shaved on their backs, and histamines phosphate 0, 01mg/0, 05ml were injected intradermally along both sides of the midline of the back, and immediately after iv0, 5% Evans blue solution 10ml/kg, and the amount of blue spot dye exudation was measured after 20 minutes by peeling off the skin of the blue spot. As a result, Angelica sinensis did not have a significant effect on the increase in capillary permeability by histamine.

(6) Effect on PGE2 content in rat inflammatory tissue.

Rats were taken and randomly grouped, 7 per group. At 0.5 hour after the last administration, the rats were sacrificed 3 hours after inflammation by using 0.1ml of scl% carrageenan on the right hind foot pad, the inflamed hind foot pad was cut at 0.5cm above the ankle joint, weighed, peeled, soaked in 5ml of physiological saline for 1 hour, the paw was removed, centrifuged, and the supernatant (Dayue et al, J.Chinesis, 1989; 14 (7): 47) was collected and the absorbance value was measured at 278nm using 751 spectrophotometer. The content of PGE2 was expressed as an equivalent absorbance value per gram of inflamed tissue. As a result, Angelica sinensis significantly reduced PGE2 content in the material tissue. As a result, angelicae sinensis significantly reduced the content of PGE2 in inflammatory tissues.

(7) The influence on the proliferation of rat cotton ball granulation tissue.

Female SD rats were taken and randomly grouped, 9 per group. Under ether anesthesia, 1 sterile cotton ball with the weight of 20 +/-lmg is respectively embedded under axilla of the forelimb at both sides. Administration was performed on the day of surgery for 7 consecutive days, rats were sacrificed by exsanguination on day 8, and granulation tissue was dissected. Positive control im hydrocortisone 0.01g/kgx 7. The granulation tissue was dried at 80 ℃ for 3 hours and weighed, and the thymus and adrenal gland of each mouse were weighed at the same time. As a result, the angelica sinensis 8g/kg group has obvious inhibition effect on cotton ball granulation tissue proliferation, but has no obvious influence on the weight of thymus and adrenal gland.

(8) Effect on hemolytic activity of guinea pig serum complement.

Guinea pigs were taken and randomly grouped, 7 per group. L hours after the last administration, the heart was sampled aseptically, and serum was prepared and tested for hemolytic activity of the classical pathway of serum complement according to the modified Mayer's semiquantitative method (clinical biochemistry examination, Hunan science and technology Press, 1981). Half hemolysis value (ACH 50) was calculated. The serum to be tested was tested for the hemolytic activity of alternative complement pathway according to the literature (Zhang Danfu et al, proceedings of Anhui medical school, 1985). Half hemolysis value (ACH 50) was calculated. As a result, Angelica sinensis has a significant inhibitory effect on the hemolytic activity of the alternative complement pathway without affecting the hemolytic activity of the classical complement pathway.

The above studies suggest that the anti-inflammatory mechanism of action of Dang Gui mainly involves:

1. decrease capillary permeability;

2. inhibiting the synthesis or release of PGE 2.

In addition, reduction of hemolytic activity of guinea pig alternative complement pathway may also be one of its anti-inflammatory mechanisms.

9) Nervous system inhibitory action

The inhibitory effect of Dang Gui on the central nervous system has been reported for a long time. Japanese scholars report that essential oil of Nippon taiwang (An-gelicaacinoboba Kitagala) has sedative, hypnotic, analgesic, anesthetic, etc. effects.

(1) Effect of ligustilide on spontaneous Activity in mice

An emulsion is prepared by using 2.8 percent of Tween-80 for later use. 1 mouse is put into the activity box each time, the activity times of the mouse 10 minutes before and 10-20 minutes after the administration are recorded by a YSD-4 type multi-purpose instrument for pharmacological and physiological experiments, and the results are compared with the known medicine diazepam and amphetamine, and the results show that: 98mg/kg of 1% ligustilide significantly reduced the spontaneous activity of the mice, and when the activity of the mice was significantly reduced compared to the control group, it was also observed that the mice were extremely quiet, but did not sleep, and still responded to mild irritation. This phenomenon is similar to settling. Angelica also contains succinic acid and ferulic acid, and succinic acid is reported to have a sedative effect while sodium ferulate is reported to reduce the number of mouse activities, but is not significantly different from the control group.

(2) Effect of ligustilide on the excitatory action of ketamine

Animals and experimental methods were as above. The number of mouse activities was recorded at 0-10 min, 10-20 min before and after dosing. The results show that: the 0.5% ketamine 40mg/kg resulted in mice that were agitated, climbed endlessly within the kit, and had a significant increase in activity times over that before administration. At the same time, 98mg/kg and 196mg/kg of ligustilide can obviously reduce the reaction caused by ketamine, and the efficacy of the ligustilide is positively correlated with the dosage. The central inhibition of ketamine aggravated by sleep, anesthesia and the like is not shown.

(3) Action of ligustilide on electrical stimulation induced mouse irritability reaction

The mouse male and female are half each, two of the same sex are a pair, the mouse male and female are connected with the conductive copper net by the multi-purpose instrument, the stimulation is continuously carried out, 1 time of pulse is output in 1 second, the stimulation duration is 1/8 seconds, and the output alternating voltage is 92 and 8 volts. The time before and 10 minutes after administration was recorded, 1 of the irritative response (erectness of the mouse, detachment of both forelimbs, pair-wise mutual avulsion) in the mouse. As a result: the time of the irritability reaction of the mice induced by the electric stimulation can be obviously prolonged 10 minutes after the administration of 294mg/kg of 3% ligustilide, the difference with the control group is very obvious, and the effect of the ligustilide is similar to that of chlorpromazine.

(4) Synergistic effect of ligustilide and barbital sodium

When the ambient temperature is kept at 25-28 ℃, 98mg/kg and 196mg/kg of ligustilide can obviously shorten the sleep time of mice using 35mg/kg of sodium pentobarbital (taking disappearance of righting reflex as an index of sleep) and obviously prolong the maintenance time of sleep action (taking two steps of righting and returning and crawling as an indication of awakening).

10) Antibacterial effect

The angelica has antibacterial effects on in vitro dysentery, typhoid, paratyphoid, escherichia coli, diphtheria bacillus, vibrio cholerae, alpha and B hemolytic streptococcus and the like. Po the product can reduce capillary permeability of mice. The external application can accelerate the healing of rabbit ear wound, lead local congestion, leukocyte and fiber infiltration and regeneration of new epithelium, and has the functions of stopping bleeding and strengthening peripheral circulation on local tissues. It is indicated that Dang Gui has antibacterial and anti-inflammatory effects. The traditional Chinese medicine composition can be clinically used for treating suppurative maxillary sinusitis, acute nephritis, iliac phlebitis, scleroderma, psoriasis and other diseases. The angelica sinensis hot water extract has obvious inhibiting effect on the acute attack of adjuvant arthritis of a chronic rheumatic disease experimental animal model.

17. Licorice root, radix Glycyrrhizae

Licorice (scientific name: Glycyrrhiza uralensis Fisch) alternative name: radix Angelicae Dahuricae, radix Glycyrrhizae, and radix Glycyrrhizae. Leguminous and glycyrrhiza herbs belong to perennial herbs, and the roots and the rhizomes are strong, so the Chinese herbal medicine is a tonifying Chinese herbal medicine. The medicinal part is root and rhizome, and the medicinal root is cylindrical, 25-100 cm long and 0.6-3.5 cm in diameter. The skin has different elasticity, and the surface is reddish brown or grayish brown. The root and stem are cylindrical, the surface has bud mark, and the middle of the section has marrow. Light smell, sweet and special taste. The main effects and effects of licorice are:

1) it can be used for treating heart-qi deficiency, palpitation, intermittent pulse, spleen and stomach qi deficiency, listlessness, and asthenia. The former is usually combined with Gui Zhi, such as Gui Zhi gan Cao Tang and gan Cao Zhi Tang. The latter is often combined with Dang Shen and Bai Zhu, such as Sijun Zi Tang and Lian Zhong Wan.

2) It is used to treat carbuncle, ulcer, sore and sore throat. It can be used singly, orally or externally, or combined. For abscess, deep-rooted carbuncle, sores and ulcers, it is often combined with jin Yin Hua and Lian Qiao to play the role of clearing heat and removing toxicity, such as Xian Fang Huo Ming Yin. For swollen and sore throat, it is often combined with Jie Geng, such as Jie Geng Tang. For intoxication by pesticide and food, it is often combined with mung bean or decocted with Fang Feng water for oral administration.

3) Can be used for treating asthma and cough. It can be used singly or combined with other herbs. For example, ERCHEN decoction for treating cough due to damp phlegm; ling gan Wu Wei Jiang Xin Tang for treating cough and asthma due to cold-phlegm; mulberry and apricot decoction for treating cough due to dry phlegm; radix Platycodi decoction for treating lung abscess, coughing up saliva, stinking up and purulent phlegm due to heat-toxin; and licorice dry ginger decoction for treating cough, spittle and sialorrhea. It is also often combined with wind-heat cough, wind-cold cough and heat-phlegm cough.

4) It is used for treating stomach ache, abdominal pain and acute contracture pain of gastrocnemius, and is often combined with peony to enhance the curative effect of treating acute contracture pain, such as peony-licorice decoction.

5) Is used for harmonizing the intensity of certain medicines. For example, the flavoring Chengqi decoction can alleviate the purgative effect of Da Huang and Mang Xiao and the irritation to the gastrointestinal tract. In addition, it is commonly used in many prescriptions to coordinate the actions of the drugs.

6) Licorice root has the similar effect of adrenocortical hormone. Has inhibitory effect on hyperacidity caused by histamine; it also has antacid and spasmodic effects on smooth muscle of stomach and intestine.

7) Licoflavone, glycyrrhiza extract and glycyrrhetinic acid have obvious cough relieving effect; the phlegm eliminating effect is also obvious, and the action strength is glycyrrhizic acid, licoflavone and liquorice extract.

8) The Glycyrrhrizae radix has antiinflammatory and antiallergic effects, and can protect inflamed throat and trachea mucosa. The glycyrrhiza extract and glycyrrhizic acid have detoxifying effect similar to that of glucuronic acid on certain toxicants.

9) Licorice is commonly used to treat symptoms accompanying menopause because it contains liquiritigenin, a hormone-like compound that helps to balance the hormone content in women.

10) The hypochlorous acid contained in Glycyrrhrizae radix can block carcinogen from inducing tumor growth.

18. Halloysitum rubrum

Halloysitum rubrum is silicate mineral halloysite, which mainly contains hydrous aluminum silicate. After digging, impurities are removed. The product is a mass, and is in irregular block shape. Pink, red to purple, or patterns alternating red and white. Soft and fragile, and has wax-like luster on the cross section. The water absorption is strong. Has a clayey smell, a light taste and no sand feeling when being chewed. The main effects and actions of Halloysitum rubrum:

1) antidiarrheal Halloysitum rubrum contains a large amount of aluminum silicate, and is orally administered to adsorb toxic substances in digestive tract, such as phosphorus, mercury, bacterial toxin, abnormal fermentation product and inflammatory exudate, and cover intestinal mucosa to reduce irritation to gastrointestinal tract, and has adsorptive antidiarrheal effect.

2) The hemostasis effect experiment shows that: the Halloysitum rubrum mixture can obviously shorten the blood coagulation time and the bleeding time, and has very obvious difference (P < 0.001) compared with the rhubarb and normal saline control group.

19. White pepper

White pepper is a dried nearly ripe fruit of pepper of the family Piperaceae. The spice has fragrant smell and is one of the favorite condiments. Pungent and warm. Warming the middle-jiao to dispel cold, descending qi, and eliminating phlegm; the surface is yellowish white or pale yellowish white, smooth, and has a plurality of light color linear stripes between the top and the base. The medicinal value of the black pepper is slightly higher than that of the black pepper. The main effects and functions of white pepper are:

1) the main component of pepper is piperine, and also contains a certain amount of aromatic oil, crude protein, starch and soluble nitrogen, the picture (20 pieces) of white pepper has the functions of removing fishy smell, removing greasiness and helping digestion, and the aromatic smell of the picture can make people have a wide appetite and stimulate appetite;

2) the pepper is warm in nature, is good at warming middle energizer and dispelling cold, has good relieving effect on stomach and abdomen psychroalgia and borborygmus diarrhea caused by stomach cold, and can promote sweating and treat wind-cold type common cold;

3) the dishes with pepper are not easy to deteriorate, which shows that pepper has the functions of antisepsis and bacteriostasis, and can relieve the botulism of fish and shrimp.

The invention has the technical effects and advantages that:

the invention relates to a wound healing formula which comprises the following components in parts by weight: 80-100 parts of dragon's blood, 85-95 parts of catechu, 80-100 parts of pseudo-ginseng, 85-95 parts of prepared frankincense, 8-12 parts of borneol, 8-12 parts of musk, 160 parts of crinis carbonisatus 140, 25-35 parts of camphor, 25-35 parts of calomel, 85-95 parts of prepared myrrh, 85-95 parts of calcined gypsum, 80-100 parts of calcined keel, 25-35 parts of lithospermum, 20-40 parts of angelica dahurica, 25-35 parts of angelica, 20-40 parts of liquorice, 160 parts of red halloysite 140 and 85-95 parts of white pepper. The invention can be widely used for various wound infections, has short treatment time, high healing rate and obvious curative effect, obviously relieves pain after being used for 1 to 2 hours, can generate fresh granulation tissues after 2 to 3 days, obviously reduces lacunar secretions, cleans the wound surface and does not need oral antibiotics.

The preparation method of the wound healing formula comprises the following steps: selecting the medicinal materials with better quality for standby; drying the above medicinal materials for use; placing the dried medicinal materials into a stirring barrel, and mixing at a speed of 30-40 rpm for more than fifteen minutes; adding the uniformly mixed medicinal materials into a grinding machine and processing into medicinal powder; sieving the ground medicinal powder with a 180-mesh sieve, and uniformly sieving; irradiating the sieved powder with ultraviolet rays (lamp) for at least one hour, and bottling.

Further, a mixture can be added before bottling the medicinal powder, wherein the mixture is one or more of deionized water, beeswax, sesame oil and vaseline, and the mixture is prepared into paste. The prescription in the application is scientifically and organically combined, so that a patient can recover from the wound with extremely small side effect in a short period, the optimal processing method can ensure scientific preparation of the medicine, the effective components are reserved, the effective rate is almost one hundred percent, and the trouble of using antibiotics is avoided; furthermore, the formula has good effect after long-term and large amount of clinical practices, is simple to use and is very compatible with people in cost; when in use, the wound margin skin is disinfected conventionally, the wound surface is cleaned, then the medicinal powder is scattered into the wound surface, and the wound surface is wrapped by sterile gauze; changing the medicine once a day or every other day according to the infection degree, wherein the dosage is 1-2g each time until healing; the formula is 100g, the cost is about 400 yuan, the dosage of medicine powder for each time of changing medicine is 4-8 yuan, and the medicine can be accepted by patients; the pain is obviously relieved after the medicine is taken for 1-2 hours, fresh granulation tissue can be generated after 2-3 days, lacunar secretion is obviously reduced, the wound surface is clean, and no oral antibiotics are needed.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention provides a wound healing formula which comprises the following components in parts by weight: 80-100 parts of dragon's blood, 85-95 parts of catechu, 80-100 parts of pseudo-ginseng, 85-95 parts of prepared frankincense, 8-12 parts of borneol, 8-12 parts of musk, 160 parts of crinis carbonisatus 140-containing materials, 85-95 parts of prepared myrrh, 25-35 parts of camphor, 25-35 parts of calomel, 85-95 parts of calcined gypsum, 80-100 parts of calcined keel, 25-35 parts of lithospermum, 20-40 parts of angelica dahurica, 25-35 parts of angelica, 20-40 parts of liquorice, 160 parts of red halloysite 140-containing materials, 85-95 parts of white pepper, 15-20 parts of euglena, 8 parts of wax apple extract and 12 parts of fresh orange peel extract.

The preparation method of the wound healing formula specifically comprises the following steps:

selecting the medicinal materials with better quality for standby;

drying the above medicinal materials for use;

irradiating the sieved powder with ultraviolet rays (lamp) for at least one hour, and bottling.

The extracts and process steps not described in detail in this example, such as drying, were extracted by the prior art.

Example 1

A preparation method of a wound healing formula specifically comprises the following steps:

according to the weight parts, 90 parts of dragon's blood, 90 parts of catechu, 90 parts of pseudo-ginseng, 90 parts of prepared frankincense, 10 parts of borneol, 90 parts of prepared myrrh, 10 parts of musk, 150 parts of crinis carbonisatus, 30 parts of camphor, 30 parts of calomel, 90 parts of calcined gypsum, 90 parts of calcined keel, 30 parts of lithospermum, 30 parts of angelica dahurica, 30 parts of angelica, 30 parts of liquorice, 150 parts of red halloysite and 90 parts of white pepper with better quality are selected for standby;

drying the above medicinal materials for use;

putting the dried medicinal materials into a stirring barrel, and uniformly mixing at the speed of 30 revolutions per minute for fifteen minutes;

irradiating the sieved powder with ultraviolet rays (lamp) for 90 min, and bottling.

Further, 18 parts of euglena; the Euglena comprises one or more of Chlamydomonas, Lupinus pinnatifida, and Microcoleus powder.

In the embodiment of the application, the formula is used as follows: disinfecting wound margin skin by a conventional method, cleaning the wound surface, then scattering the medicinal powder into the wound surface, and wrapping with sterile gauze; the medicine is changed once a day or every other day according to the infection degree, and the dosage is 1-2g each time until healing. The formula is 100g, the cost is about 400 yuan, the dosage of medicine powder for each time of changing medicine is 4-8 yuan, and the medicine can be accepted by patients; the pain is obviously relieved after the medicine is taken for 1-2 hours, fresh granulation tissue can be generated after 2-3 days, lacunar secretion is obviously reduced, the wound surface is clean, and no oral antibiotics are needed.

The following is a comparative table of healing of 1000 patients using the formulation of this example and the general drug

Index of medication	Common wound medicine	The patent wound healing formula
			Time of healing	5 days	2 days
Mild pain relief	Is not obvious	Is obvious
			Wound exudate	Much more	Is rarely used
Whether antibiotics need to be taken or not	Need to make sure that	Without the need for
			High efficiency	83.20%	96.95%

The extracts not described in detail in this example were extracted by the prior art.

Example 2

according to the weight parts, 80 parts of dragon's blood, 85 parts of catechu, 80 parts of pseudo-ginseng, 85 parts of prepared frankincense, 8 parts of borneol, 8 parts of musk, 85 parts of prepared myrrh, 140 parts of crinis carbonisatus, 25 parts of camphor, 25 parts of calomel, 85 parts of calcined gypsum, 80 parts of calcined keel, 25 parts of lithospermum, 20 parts of angelica dahurica, 25 parts of angelica, 20 parts of liquorice, 140 parts of red halloysite and 85 parts of white pepper with better quality are selected for standby;

drying the above medicinal materials for use;

putting the dried medicinal materials into a stirring barrel, and uniformly mixing at the speed of 35 revolutions per minute for twenty minutes;

irradiating the sieved powder with ultraviolet rays (lamp) for 60 min, and bottling.

Further, 15 parts of euglena are also included; the Euglena comprises one or more of Chlamydomonas, Lupinus pinnatifida, and Microcoleus powder.

Index of medication	Common wound medicine	The patent wound healing formula
			Time of healing	4 days	1.5 days
Mild pain relief	Is not obvious	Is quite obvious
			Wound exudate	Is provided with	Is rarely used
Whether antibiotics need to be taken or not	Need to make sure that	Without the need for
			High efficiency	78.35%	99.01%

In the embodiment of the application, the formula is used as follows: disinfecting wound margin skin by a conventional method, cleaning the wound surface, then scattering the medicinal powder into the wound surface or coating the wound surface with the medicinal ointment, and wrapping with sterile gauze; the medicine is changed once a day or every other day according to the infection degree, and the dosage is 1-2g each time until healing. The formula is 100g, the cost is about 400 yuan, the dosage of medicine powder for each time of changing medicine is 4-8 yuan, and the medicine can be accepted by patients; the pain is obviously relieved after the medicine is used for 1 to 2 hours, fresh granulation tissue can be generated after 1.5 days, lacunar secretion is obviously reduced, the wound surface is clean, no antibiotics need to be orally taken, and the wound surface has the best effect on wound surfaces after debridement and suturing operation, burns and scalds, diabetic feet, bedsores and the like.

Example 3

selecting 100 parts of dragon's blood, 95 parts of prepared myrrh, 95 parts of catechu, 100 parts of pseudo-ginseng, 95 parts of prepared frankincense, 12 parts of borneol, 12 parts of musk, 160 parts of crinis carbonisatus, 35 parts of camphor, 35 parts of calomel, 95 parts of calcined gypsum, 100 parts of calcined keel, 35 parts of lithospermum, 40 parts of angelica dahurica, 35 parts of angelica, 40 parts of liquorice, 160 parts of red halloysite and 95 parts of white pepper with better quality according to the parts by weight for later use;

drying the above medicinal materials for use;

putting the dried medicinal materials into a stirring barrel, and uniformly mixing at a speed of 40 revolutions per minute for twenty-five minutes;

irradiating the sieved powder with ultraviolet rays (lamp) for 75 min, and bottling.

Further, 20 parts of euglena; the Euglena comprises one or more of Chlamydomonas, Lupinus pinnatifida, and Microcoleus powder.

Index of medication	Common wound medicine	The patent wound healing formula
			Time of healing	3 days	3 days
Mild pain relief	With mitigation	Obvious lightening
			Wound exudate	Are much more	Is rarely
Whether antibiotics need to be taken or not	Need to make sure that	Without the need for
			High efficiency	85.20%	99.915%

In summary, the formula in the application is scientifically and organically combined, so that a patient can recover from trauma with extremely small side effect in a short period of time, the optimal processing method can ensure scientific preparation of the medicine, effective components are reserved, the effective rate is almost one hundred percent, and the trouble of using antibiotics is avoided; furthermore, the formula has good effect after long-term and large amount of clinical practices, is simple to use and is very compatible with people in cost; when in use, the wound margin skin is disinfected conventionally, the wound surface is cleaned, then the medicinal powder is scattered into the wound surface or the medicinal ointment is coated on the wound surface, and the wound surface is wrapped by sterile gauze; changing the medicine once a day or every other day according to the infection degree, wherein the dosage is 1-2g each time until healing; the formula is 100g, the cost is about 400 yuan, the dosage of medicine powder for each time of changing medicine is 4-8 yuan, and the medicine can be accepted by patients; the pain is obviously relieved after the medicine is taken for 1-2 hours, fresh granulation tissue can be generated after 2-3 days, lacunar secretion is obviously reduced, the wound surface is clean, and no oral antibiotics are needed.

Finally, it should be noted that: the above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that are within the spirit and principle of the present invention are intended to be included in the scope of the present invention.

Claims

1. A wound healing formula is characterized by comprising the following components in parts by weight: 80-100 parts of dragon's blood, 85-95 parts of catechu, 80-100 parts of pseudo-ginseng, 85-95 parts of prepared frankincense, 85-95 parts of prepared myrrh, 8-12 parts of borneol, 8-12 parts of musk, 140-160 parts of crinis carbonisatus, 25-35 parts of camphor, 25-35 parts of calomel, 85-95 parts of calcined gypsum, 80-100 parts of calcined keel, 25-35 parts of lithospermum, 20-40 parts of angelica dahurica, 25-35 parts of angelica, 20-40 parts of liquorice, 140-160 parts of red halloysite and 85-95 parts of white pepper.

2. The wound healing formulation according to claim 1, comprising in parts by weight: 90 parts of dragon's blood, 90 parts of catechu, 90 parts of pseudo-ginseng, 90 parts of prepared frankincense, 10 parts of borneol, 10 parts of musk, 150 parts of crinis carbonisatus, 30 parts of camphor, 30 parts of calomel, 90 parts of calcined gypsum, 90 parts of calcined keel, 30 parts of lithospermum, 90 parts of prepared myrrh, 30 parts of angelica dahurica, 30 parts of angelica, 30 parts of liquorice, 150 parts of red halloysite and 90 parts of white pepper.

3. The wound healing formulation according to claim 1, comprising in parts by weight: 80 parts of dragon's blood, 85 parts of catechu, 80 parts of pseudo-ginseng, 85 parts of prepared myrrh, 85 parts of prepared frankincense, 8 parts of borneol, 8 parts of musk, 140 parts of crinis carbonisatus, 25 parts of camphor, 25 parts of calomel, 85 parts of calcined gypsum, 80 parts of calcined keel, 25 parts of lithospermum, 20 parts of angelica dahurica, 25 parts of angelica, 20 parts of liquorice, 140 parts of red halloysite and 85 parts of white pepper.

4. The wound healing formulation according to claim 1, comprising in parts by weight: 100 parts of dragon's blood, 95 parts of catechu, 100 parts of pseudo-ginseng, 95 parts of prepared myrrh, 95 parts of prepared frankincense, 12 parts of borneol, 12 parts of musk, 160 parts of crinis carbonisatus, 35 parts of camphor, 35 parts of calomel, 95 parts of calcined gypsum, 100 parts of calcined keel, 35 parts of lithospermum, 40 parts of angelica dahurica, 35 parts of angelica, 40 parts of liquorice, 160 parts of red halloysite and 95 parts of white pepper.

5. A wound healing formulation according to any one of claims 1 to 4, wherein: 15-20 parts of euglena; the Euglena comprises one or more of Chlamydomonas, Lupinus pinnatifida, and Microcoleus powder.

6. The wound healing formulation of claim 5, wherein: also comprises 8 parts of wax apple extract and 12 parts of fresh orange peel extract.

7. A method of preparing a wound healing formulation according to any one of claims 1 to 6, comprising the steps of:

selecting the medicinal materials with better quality according to any one of claims 1 to 6 for standby;

drying the above medicinal materials for use;

8. The method of preparing a wound healing formulation according to claim 7,

the mixture can be added before bottling, and the mixture is one or more of deionized water, Cera flava, oleum Sesami and vaseline.

9. The method of preparing a wound healing formulation according to claim 7,

the preparation method of the wax apple extract comprises the following steps: freezing wax apples at the temperature of 30-minus 10 ℃ for 1.6-2.0 h, adding water for pulping, and blanching by a hot water bath at the temperature of 100 ℃ for 12-20 min to obtain wax apple pulp; using 18-25% ethanol as solvent, extracting at 80-90 deg.C for 3 times (each time for 2-4 hr) with solvent amount 10-14 times of the weight of Syzygium samarangense; filtering, mixing extractive solutions, recovering ethanol, concentrating to relative density of 0.98-1.2, and filtering to obtain medicinal liquid A;