CN109248258A - Nursing Chinese herbal medicine gargle after a kind of operation on oral cavity - Google Patents
Nursing Chinese herbal medicine gargle after a kind of operation on oral cavity Download PDFInfo
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention discloses nursing Chinese herbal medicine gargle after a kind of operation on oral cavity, including sorrow is escaped 5-15 parts careless, 4-12 parts of Blumea balsamifera, 8-10 parts of Paederia scandens, Radix Ophiopogonis 7-10 part, 7-9 parts of wedelia chinensis, 6-9 parts callicarpa nudiflora, 1-5 parts of Chinese fanpalm seed, 1-5 parts, 10-15 portions wax gourds of green tea, 50-75 parts of water.Using nursing Chinese herbal medicine gargle after a kind of operation on oral cavity provided by the present invention, not only containing the effective component of formula Chinese herbal, swelling and pain relieving, and wax gourd tea is added, on the one hand Chinese medicine odor is fallen in absorption, and faint scent is pleasant;On the other hand increase plant sugared content, promote mouthfeel, nurse and use after for operation on oral cavity, have obviously good preventive and therapeutic effect to the complication such as inflammation swelling and pain, nausea, dry mouth with bitter taste, canker sore and bleeding gums.
Description
Technical field
The present invention relates to nurse in use after belonging to oral care health treatment technical field more particularly to a kind of operation on oral cavity
Careless gargle.
Background technique
Periodontal surgery, implant operation and Oral and Maxillofacial Surgery etc. are postoperative to be easy to appear wound infection, and occur together nausea, mouth
The serious complications such as dry, bitter taste, pharyngalgia, swelling, ulcer or bleeding gums.At present can be used anti-inflammatory drug or drug gargle into
Row processing, drug gargle be auxiliary prevention and treatment mouth disease and complication and study it is a kind of containing gargle and liquid,
According to component difference, drug gargle is had more using relatively on the market at present:
1, triclosan gargle: triclosan is a kind of mild antibacterials, chemical name triclosan, triclosan conduct
A kind of new antibacterial agent initially enters gargle field, as safe and efficient broad spectrum antimicrobial agent, has height to harmful bacteria in oral cavity
Imitate inhibiting effect, and can directly inhibit the generation of inflammatory mediator, and stingless excitation, without bitter taste, have become in western countries at present
Most commonly used mild nonionic types of antimicrobials in the gargle in city.
2, tea polyphenols gargle: tea polyphenols are the polyphenol compound complexs of the separation and Extraction from tealeaves, can reduce tooth
The quantity of bacterial plaque and its adherency on facing, it is also inhibited to cariogenic bacteria and bacterial plaque.
3, chlorohexidene gargle: chlorohexidene is also known as Chlorhexidine, is most widely used, the strongest drug of antiplaque ability.Containing gargling
Liquid concentration is 0.1%~0.5%, and effective antimicrobial concentration is 100ug/ml-0.1ug/ml, can completely inhibit bacterial plaque and be formed.
4, antibiotic gargle: most common antibiotic gargle has the metronidazole and 0.06% of 0.01%-0.03%
Tetracycline effectively can inhibit bacterial plaque to be formed, and improve gingivitis situation.
The above drug gargle main component is Western medicine, though definite ingredients, can play certain effect, side effect is big and nothing
Method prevents and treats pH in postoperative oral environment (peracid or crossing alkali) comprehensively and bacterium colony changes caused serious complications, especially
The immunity of body can decline after anesthesia, and induced factor is complicated, need to be treated with Chinese medical discrimination method.
Summary of the invention
In view of this, the present invention provides nursing Chinese herbal medicine gargle after a kind of operation on oral cavity, by scientific compatibility and
Homemade method, on the one hand by adjust oral environment in pH and inhibit bacterium colony, on the other hand by Chinese herbal medicine compatibility it is effective at
Divide and wound surface is treated more, solves existing oral cavity Prevention from Complications and its medium-height grass flavour of a drug smell and be not suitable for very much preparation again
The problem of gargle.
The technological means that the present invention uses is as follows: nursing Chinese herbal medicine gargle after a kind of operation on oral cavity, including sorrow is escaped grass
5-15 parts, 4-12 parts of Blumea balsamifera, 8-10 parts of Paederia scandens, Radix Ophiopogonis 7-10 part, 7-9 parts of wedelia chinensis, 6-9 parts callicarpa nudiflora, Chinese fanpalm seed
1-5 parts, 1-5 parts, 10-15 portions wax gourds of green tea, 50-75 parts of water.
Preferably, nursing Chinese herbal medicine gargle after a kind of operation on oral cavity, including sorrow are escaped careless 15 parts, 12 parts of Blumea balsamifera, chicken
10 parts of dung rattan, 10 parts of Radix Ophiopogonis, 9 parts of wedelia chinensis, 9 parts callicarpa nudiflora, 5 parts of Chinese fanpalm seed, 5 parts, 15 portions wax gourds of green tea and 75 parts of water.
On the other hand a kind of preparation method of nursing Chinese herbal medicine gargle after operation on oral cavity, including following step are provided
It is rapid:
S101 weighs escape grass, Blumea balsamifera, Paederia scandens, Radix Ophiopogonis, wedelia chinensis, callicarpa nudiflora, Chinese fanpalm seed and water of sorrow in proportion and adds
Heat to 50 DEG C of immersion 0.5h, after 2h is decocted at 100 DEG C, filter, taking filtrate to be concentrated into medicinal extract makes medicinal extract solid content 25%,
It is cooled to room temperature, medicinal extract is slowly added in the ethanol solution that ethanol content is 65%, takes upper layer second in 10 DEG C of stand at low temperature 5h
Alcoholic solution is concentrated and dried to obtain Chinese medical extract;
The water infusion 0.5h of 5 times of weight is added toward fresh wax gourd by S102, and the rear green tea that is added carries out extraction 10min, and filter residue obtains
Obtain wax gourd tea;
The wax gourd tea in S102 is added in the Chinese medical extract of S101 by S103, is heated to 50 DEG C and is stirred, enzyme deactivation, very
Sky deaerates, canned acquisition gargle after pasteurization.
Preferably, enzyme deactivation is the bacteriolyze enzymatic treatment 10min for being added 0.01%, and the vacuum outgas is in temperature 45 C, 90kpa
Lower progress, the pasteurization spray 35min at 90 DEG C.
Using nursing Chinese herbal medicine gargle after a kind of operation on oral cavity provided by the present invention, pass through scientific compatibility, extracts
Medium-height grass the effective elements of the medicine, adds the mixing of wax gourd tea, and the absorption of one side wax gourd falls Chinese medicine odor, distributes light green tea tea
It is fragrant;On the other hand increase plant sugar, promote mouthfeel, nurse and use after for operation on oral cavity, by adjusting in oral environment
PH and bacterium colony balance have the complication such as inflammation swelling and pain, nausea, dry mouth with bitter taste, canker sore and bleeding gums obviously good
Preventive and therapeutic effect.
Specific embodiment
The principles and features of the present invention are described below, and illustrated embodiment is served only for explaining the present invention, is not intended to
It limits the scope of the invention.
The present invention selects Chinese herbal medicine, experimental facilities to be acquired and provided by Hainan Medical College.
Sorrow escapes grass as the plant of Acanthaceae crocodile mouth flower category, contains lupeol, betulin, pentacyclic triterpene compound, Beta
The ingredients such as sitosterol, calcium constituent, flavonoids, it is sweet in flavor, pungent, slight bitter, mild-natured, enter liver and kidney channel, have clearing heat and detoxicating, eliminating stasis to subdue swelling,
The effects of anti-inflammatory relieves the effect of alcohol, cancer-resisting.Herb and root can be used as medicine, and it is spare to dry chopping.
Blumea balsamifera is composite family Blumea balsamifera category, and plant contains blumealactone, flavanones, (2R, 3R) -7,5 '-dimethoxies
Base -3,5,2 '-trihydroxy flavanones, cryptomeridiol and borneol ingredient.Stagnated fire is dissipated with all keys are led to, swelling and pain relieving and other effects is used
In controlling cold-dampness dysentery, abdominal pain borborygmus, swelling, arthralgia and myalgia, traumatic injury and tinea sore etc..Herb can be used as medicine, and it is spare to dry chopping.
Genus rubia section of Paederia scandens section, Paederia.Sweet in flavor, sour, mild-natured, return heart, liver,spleen,kidney warp.Dispelling wind and eliminating dampness helps digestion
Change product, removing toxicity for detumescence, promoting blood circulation and stopping pain.Cure mainly rheumatic arthralgia, dyspeptic abdominal distention, infantile malnutrition, diarrhea, dysentery, heatstroke, jaundice, liver
Inflammation, hepatosplenomegaly, cough, scrofula, acute appendicitis, nameless sores or boils, the wet rotten, burn and scald that swells of foot, eczema, dermatitis, traumatic injury and snake flood dragon
Scorpion stings.Herb and root can be used as medicine, and it is spare to dry chopping.
Radix Ophiopogonis is Liliaceae, is in spindle, both ends are slightly sharp, long 1.5-3cm, diameter 0.3-0.6cm.Surface yellow-white is light
Yellow has thin longitudinal grin.Matter is flexible, and section yellow-white, translucent, center pillar is tiny.Gas micro-perfume, sweet in flavor, slight bitter.It is raw to cure mainly yin-nourishing
Saliva, moistening lung and clearing away the heart-fire.For dryness of the lung dry cough.Tuberculosis cough, injury thirst, vexed insomnia, Heat Diabetes, dry constipation of intestines;Pharyngeal diphtheria.
Root tuber can be used as medicine, and it is spare to dry chopping.
Wedelia chinensis belongs to composite family amphibious crab Chrysanthemum, contains melissic acid, lignoceric acid, stigmasterol, stigmasterol glycoside,
Left-handed-Kaurenic acid.Cure mainly clearing heat and detoxicating, cool blood dissipates the stasis of blood, cold, fever, sphagitis, tonsillitis, rib inflammation, diphtheria, hundred
Day cough, tracheitis, pneumonia, hemoptysis of pulmonary tuberculosis, nosebleed epistaxis, hematuria, catarrhal jaundice, dysentery, hemorrhoid.Herb can be used as medicine, and dry and cut
It is broken spare.
Callicarpa nudiflora Verenaceae Callicarpa bodinieri Levl. platymiscium, this product normal shrinkage curling is round in ovum shape lanceolar or square after flattening,
Long 6-8cm, wide 4-8cm;Top is short tapering to tapering, and base portion is blunt or slightly rounded, and edge, which has, dredges tooth, wavy or nearly full edge.
Upper surface black, lower surface are close by dense yellowish-brown stellate hair.Lateral vein pinniform scun is closely several at right angle with lateral vein in parallel.Petiole
Long 0.5-3cm, by stellate hair.Bitter, micro-pungent is put down, returns spleen, stomach, Liver Channel, and hemostasis, dissolving stasis, analgesic are cured mainly.For lung hemoptysis, stomach and intestine
Bleeding, nosebleed epistaxis, gingiva bleeding gingival hemorrhage, traumatic hemorrhage, traumatic injury, rheumatism swelling and pain etc..Leaf can be used as medicine, and dry spare.
Chinese fanpalm seed be babassu Chinese fan palm seed, containing phenols, reduced sugar, tannin, triacylglycerol, amino acid, lysine,
Serine, arginine, proline, tyrosine, valine, isoleucine, phenylalanine, vitamin C, it is sweet in flavor, bitter, mild-natured, it is main
Control activating microcirculation and removing stasis medicinal, resolving hard lump, chronic hepatitis and abdominal mass.
Embodiment one: after a kind of operation on oral cavity nursing Chinese herbal medicine gargle preparation method the following steps are included:
S101 weigh 5 parts of sorrows escape grass, 4 parts of Blumea balsamiferas, 8 parts of Paederia scandens, 7 parts of Radix Ophiopogonis, 7 portions of wedelia chinensis, 6 parts it is callicarpa nudiflora, 1
Part Chinese fanpalm seed proportion, which is added in 50 parts of water, is heated to 50 DEG C of immersions 0.5h, after 2h is decocted at 100 DEG C, filtering takes filtrate to be concentrated
Make medicinal extract solid content 25% to medicinal extract, be cooled to room temperature, medicinal extract is slowly added in the solution that ethanol content is 65%,
10 DEG C of stand at low temperature 5h take upper layer ethanol solution to be concentrated and dried to obtain Chinese medical extract;
The water infusion 0.5h of 5 times of weight is added in 10 parts of fresh wax gourds by S102, and 1 portion of green tea is added afterwards and carries out extraction 10min,
Filter residue obtains wax gourd tea.
The wax gourd tea in S102 is added in the Chinese medical extract of S101 by S103, is heated to 50 DEG C and is stirred, and is added
0.01% lysozyme enzyme deactivation 10min, carries out vacuum outgas under temperature 45 C, 90kpa, the fountain pasteurization at 90 DEG C
The canned acquisition gargle of 35min, the pH by detecting gargle are 6.8.
Embodiment two: embodiment two and the difference of embodiment one are: raw material component be added is different,
Sorrow is escaped careless 15 parts, 12 parts of Blumea balsamifera, 10 parts of Paederia scandens, 10 parts of Radix Ophiopogonis, 9 parts of wedelia chinensis, 9 parts callicarpa nudiflora, Chinese fan palm
Sub 5 parts, 5 parts, 15 portions wax gourds of green tea, 75 parts of water, the pH by the gargle for detecting the present embodiment are 7.0.
1, the gargle in embodiment one and embodiment two is subjected to organoleptic indicator's test, has dense tea smell, it is bright orange
Color, delicate mouthfeel.
2,80 periodontal surgery (local anaesthesia) patients of Hainan Medicine Institute, Affiliated Hospital are randomly assigned to be four groups, every group of 20 people,
It tests 1 group and oral care is carried out with Chinese herbal medicine gargle prepared by embodiment one, test 2 groups of Chinese herbal medicines prepared with embodiment two
Gargle carries out oral care, compares 1 group and carries out oral care with Xian Bitai on the market, compares 2 groups and carries out oral cavity with salt water
Nursing, 3-5 times daily, each 10-20mL come into full contact with itself and oral cavity every time containing 3-5min is gargled, and 5 days a cycles are rear to see
It examines patient's postsurgery symptoms and records.
Operation on oral cavity patient: the age has just carried out periodontal, the operation of kind tooth or Oral maxillofacial operation at 18-40 years old, in nearly three days
There are inflammation swelling and pain, 3 symptoms in nausea, dry mouth with bitter taste, canker sore and bleeding gums or more in patient afterwards.
1, cure: patient's inflammation swelling and pain, nausea, dry mouth with bitter taste, canker sore or bleeding gums complication symptom totally disappeared mistake,
It is considered as healing.
2, effectively: patient occur inflammation swelling and pain, nausea, dry mouth with bitter taste, canker sore and 1 symptom in bleeding gums and
Hereinafter, being considered as effectively.
3, invalid: patient occur inflammation swelling and pain, nausea, dry mouth with bitter taste, canker sore and 2 symptoms in bleeding gums and
More than, it is invalid to be considered as.
The Chinese herbal medicine gargle manufactured in the present embodiment of table 1 uses result
As shown in Table 1, using Chinese herbal medicine gargle of the present invention, oral cavity pH can be reconciled, so that bacterium colony be inhibited to generate, hence it is evident that
Alleviate oral cavity postoperative complications symptom, while promoting wound healing.
In conclusion passing through science using nursing Chinese herbal medicine gargle after a kind of operation on oral cavity provided by the present invention
Compatibility, it is comprehensive to extract medium-height grass the effective elements of the medicine, and wax gourd tea is added, on the one hand Chinese medicine odor is fallen in absorption, and faint scent is pleasant;Separately
On the one hand delicate mouthfeel is promoted, nurses and uses after for operation on oral cavity, to inflammation swelling and pain, nausea, dry mouth with bitter taste, canker sore
There is obvious good comprehensive preventive and therapeutic effect with complication such as bleeding gums.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent substitution, improvement and etc. done be should be included within the scope of the present invention.
Claims (4)
1. nursing Chinese herbal medicine gargle after a kind of operation on oral cavity, which is characterized in that escape 5-15 parts careless, Blumea balsamifera 4-12 including sorrow
Part, 8-10 parts of Paederia scandens, Radix Ophiopogonis 7-10 part, 7-9 parts of wedelia chinensis, 6-9 parts callicarpa nudiflora, 1-5 parts of Chinese fanpalm seed, 1-5 parts of green tea,
10-15 portions of wax gourds, 50-75 parts of water.
2. nursing Chinese herbal medicine gargle after a kind of operation on oral cavity according to claim 1, which is characterized in that escape including sorrow
Careless 15 parts, 12 parts of Blumea balsamifera, 10 parts of Paederia scandens, 10 parts of Radix Ophiopogonis, 9 parts of wedelia chinensis, 9 parts callicarpa nudiflora, 5 parts of Chinese fanpalm seed, green tea 5
Part, 15 portions of wax gourds and 75 parts of water.
3. the nursing preparation method of Chinese herbal medicine gargle, special after a kind of described in any item operation on oral cavity of claims 1 or 2
Sign is, comprising the following steps:
S101 weighs escape grass, Blumea balsamifera, Paederia scandens, Radix Ophiopogonis, wedelia chinensis, callicarpa nudiflora and Chinese fanpalm seed of sorrow in proportion and 50 parts of water is added
In be heated to 50 DEG C of immersion 0.5h, after 2h is decocted at 100 DEG C, filter, taking filtrate to be concentrated into medicinal extract makes medicinal extract solid content
25%, it is cooled to room temperature, medicinal extract is slowly added in the ethanol solution that ethanol content is 65%, is taken in 10 DEG C of stand at low temperature 5h
Layer ethanol solution is concentrated and dried to obtain Chinese medical extract;
Water infusion 0.5h is added toward fresh wax gourd in S102, and the rear green tea that is added carries out extraction 10min, and filter residue obtains wax gourd tea;
The wax gourd tea in S102 is added in the Chinese medical extract of S101 by S103, is heated to 50 DEG C and is stirred, enzyme deactivation, and vacuum is de-
Gas, canned acquisition gargle after pasteurization.
4. according to the preparation method of nursing Chinese herbal medicine gargle after a kind of described in any item operation on oral cavity of claim 3,
It is characterized in that, the enzyme deactivation is the bacteriolyze enzymatic treatment 10min for being added 0.01%, and the vacuum outgas is under temperature 45 C, 90kpa
It carries out, the pasteurization sprays 35min at 90 DEG C.
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Cited By (2)
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CN111728905A (en) * | 2020-06-02 | 2020-10-02 | 福州安得尔卫生技术开发有限公司 | Plant gargle |
CN113750198A (en) * | 2021-10-21 | 2021-12-07 | 中国热带农业科学院热带作物品种资源研究所 | Compound oral care solution and preparation method thereof |
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JP2018131412A (en) * | 2017-02-16 | 2018-08-23 | 松浦薬業株式会社 | Chinese medicine semisolid pharmaceutical composition |
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